Human herpes virus types 6, 7, and 8 were isolated in the 1980s and 1990s. HHV-6 causes roseola infantum and other mononucleosis syndromes. HHV-7 may cause exanthema subitum and neurological issues in children. HHV-8 is associated with Kaposi's sarcoma and body cavity-based lymphomas in AIDS patients. While HHV-6 and HHV-7 typically cause mild childhood illnesses, HHV-8 can cause cancer in immunocompromised individuals. These viruses are transmitted through saliva and genital secretions and can reactivate during immunosuppression.
Human herpes virus types 6, 7, and 8 were isolated in the 1980s and 1990s. HHV-6 causes roseola infantum and other mononucleosis syndromes. HHV-7 may cause exanthema subitum and neurological issues in children. HHV-8 is associated with Kaposi's sarcoma and body cavity-based lymphomas in AIDS patients. While HHV-6 and HHV-7 typically cause mild childhood illnesses, HHV-8 can cause cancer in immunocompromised individuals. These viruses are transmitted through saliva and genital secretions and can reactivate during immunosuppression.
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Human herpes virus types 6, 7, and 8 were isolated in the 1980s and 1990s. HHV-6 causes roseola infantum and other mononucleosis syndromes. HHV-7 may cause exanthema subitum and neurological issues in children. HHV-8 is associated with Kaposi's sarcoma and body cavity-based lymphomas in AIDS patients. While HHV-6 and HHV-7 typically cause mild childhood illnesses, HHV-8 can cause cancer in immunocompromised individuals. These viruses are transmitted through saliva and genital secretions and can reactivate during immunosuppression.
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Isolated in 1986 from peripheral blood Isolated in 1990 from peripheral blood T- Isolated in 1994 & 1995 in tissues from leukocytes of persons w/ lymphocytes of a healthy 26 y/o man kaposi’s sarcoma (KS) & body cavity- lymphoproliferative disorders based lymphoma in AIDS patients ♥ Aka KS-associated herpesvirus (KSHV) Worldwide distribution more common in central & southern Africa 80% of adults are sero(+) for HHV 6 concurrent epidemics of HIV-1 & HHV-8 in homosecual & bisexual men • Infection frequently develops in Infection frequently acquired during • Infects certain B lymphocytes & infancy as maternal Ab wanes childhood endothelium-derived spindle cells • Congenital infections (mostly due to • Also related to: HHV-6B) -AIDS-related B-cell body-cavity-based lymphomas & -multicentric Castleman’s dse (a lymphoproliferative B cell disorder) INFANTS & CHILDREN: • No human dse had yet been IMMUNOCOMPETENT • Examthen subitum (roseola definitively linked to HHV-7 although • Asymptomatic infection infanticum) – fever w/ subsequent the ff diseases are associated: rash ♥ Exanthema subitum IMMUNOCOMPROMISED • Febrile seizures w/o rash ♥ Childhood febrile illness • Neoplastic disorders OLDER AGE GROUPS: ♥ Neurologic syndromes • Mononcleosis syndromes (encephalitis, flaccid • Focal encephalitis paralysis) IMMUNOCOMPROMISED: ♥ Pityriasis rosea • Pneumonitis • Disseminated dse TRANSPLANT RECIPIENTS: • Graft dysfunction
*implicated in Multiple sclerosis – further
study needed MOT: saliva, genital secretions Commonly present in saliva of healthy Saliva, organ transplantation, IV drug use adults Now has 2 genetically distinct variants: HHV-6A and HHV-6B Susceptible to Ganciclovir & foscarnet Susceptible to Ganciclovir & foscarnet Susceptible to Ganciclovir, foscarnet & *clinical evidence is lacking *clinical evidence is lacking cidofovir *clinical evidence is lacking Antiretroviral therapy for HIV (+) individuals led to ↓ KS among individuals dually infected w/ HHV-8 & HIV HHV-6, HHV-7 & CMV infections may cluster in transplant recipients, thus it is difficult to sort out the roles of the various agents in individual clinical syndromes.