Anti TB Drugs
Anti TB Drugs
Less active than RFP 2nd most active ADVERSE DRUG REACTIONS [ADR] – 1ST MONTH
• Loss of appetite and tiredness without reason - INH
Pop. C • Unexplained nausea and vomiting, collapse - INH
• Rash and persistent itchiness - INH
• Yellowish discolorations of skin and eyeballs - Rifamp
Most active
2
• Flu-like syndrome- fever, chills, pain
SIDE NOTES
• Give Vitamin B complex (Pyridoxine) to prevent INH
(Isoniazid H) toxicity
• DOT – Direct Observance Therapy
• Streptomycin – Only anti TB drug administered IM
• Increased dose in INH causes convulsions
• 2 months is INTENSIVE, 4 months is MAINTENANCE
• Myrin P – Combination of the following drugs, 2 months:
(INTENSIVE)
– R = Rifampicin
– I = Isoniazid
– P = Pyrazinamide
– E = Ethambutol
• Myrin (4 months), only R I E
• Rifampicin has PAE against leprosy, it is leprocidal
• PHILCAT – Philippine Coalition Against tuberculosis
Rx regimen
I. 2 HRZE (2 RIPE) / 4HR (4 RI)
I. New pulmonary smear (+) cases
II. New seriously ill pulmonary smear negative
cases with parenchymal involvement
III. New seriously ill extrapulmonary TB cases