CINNARIZINE WARNINGS Cinnarizine should be used with caution in: the elderly, women who arepregnant or who are breastfeeding, patients with liver or kidney problems,Parkinson's disease, or a blood disorder called acute porphyria. It should not be used in: people who are allergic to cinnarizine or any other ingredient in the medicine, and in children under 5 years of age. Also see list of precautions and interactions. STORAGE No special storage conditions required. CINNARIZINE USES What is it used for? Cinnarizine is used to treat a number of problems. It is a type of antihistamine drug, sometimes known as a travel sickness or balance disorder treatment. It is used to treat vestibular disorders (balance disorders). In general this drug is used to treat balance disorders (such as in Mnires disease), including vertigo (spinning or swaying sensation when standing still), tinnitus (ringing in the ears), feeling sick (nausea) and vomiting, as well as for travel sickness (both during road journeys and sea travel). Benefits of being on this drug can include relief from, or prevention of, the symptoms of travel sickness or balance disorders. Listed below are the typical uses of cinnarizine. Treating or preventing problems with balance (such as Mnires disease) to treat symptoms of feeling dizzy or light-headed, ringing in the ears (tinnitus), feeling sick (nausea) and being sick (vomiting) To control travel sickness. On occasion your doctor may prescribe this medicine to treat a condition not on the above list. HOW TO USE/TAKE How often do I take it? Take this medication by mouth, usually three-times daily (for balance problems) or several hours before travelling and every 8 hours during travel (for travel sickness). Tablets should be taken after meals, and may be chewed, sucked or swallowed whole. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day - unless specifically told not to by your doctor. It may take up to several hours before the full benefit of this drug takes effect. Certain medical conditions may require different dosage instructions as directed by your doctor. What dose? Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines. Do I need to avoid anything? This drug may cause drowsiness, especially at the start of treatment. If affected in this way avoid driving or operating machinery. Consult your doctor or pharmacist for more details. When can I stop? when taken for balance problems, tt is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
Side effects Feeling sleepy Upset stomach or digestion Headache Dry mouth Increased sweating Weight gain Itchy bumps on the skin, sometimes with mouth sores Rashes Yellowing of the skin or eyes (jaundice) Jerky or slow movements, or muscle stiffness or trembling Restlessness More saliva than normal Twitching or unusual movements of the tongue, face, mouth, jaw or throat, or rolling of the eyes Depression. If any of these persist or you consider them severe then inform your doctor. Tell your doctor immediately if you develop any of the following symptoms: any extrapyramidal symptoms (jerky or slow movements, or muscle stiffness or trembling, restlessness, more saliva than normal, twitching or unusual movements of the tongue, face, mouth, jaw or throat, or rolling of the eyes), with or without depression; yellowing of the skin or eyes (jaundice). Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the UK you may report side-effects to the MHRA responsibilities
Before taking cinnarizine, tell your doctor or pharmacist if you are allergic to it; or to other antihistamines; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of: none known. Before using this medication tell your doctor or pharmacist your medical history, especially any of the following: any liver or kidney problems, Parkinson's disease, or a blood disorder called acute porphyria. Before having surgery, tell your doctor or dentist that you are taking this medication. Does alcohol intake affect this drug? Alcohol should be avoided when taking this drug as it may make you very sleepy. The elderly: cinnarizine should be used with caution in the elderly as it may be associated with an increased likelihood of certain adverse events such as extrapyramidal symptoms (e.g. movement disorders), with or without depression. Pregnancy and breastfeeding - please ensure you read the detailed information below PREGNANCY Cinnarizine is not safe to take if you are, or are planning to become, pregnant. It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation. If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist. BREAST FEEDING Cinnarizine is not safe to take if you are breastfeeding. It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation. If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.
Generic Name : Cinnarizine Pronunciation : cin-nar-I-zine Therapeutic Classification : Antihistamines Trade Name(s): India- Cinact, Cindail, Cinarin, Cinaver, Cingeron, Cini, Cinnasia, Cintac, Cintigo, Cinvert, Cinzan, Cinzine, Diziron, Diznil, Dizzigom Emzine, Neurozine, Novacinn, Stedicin, Stugeron, Stugeron F, Syzeron, Vergo, Verticin, Vertigon, Vertiron, Verto-C, V-Gon, Zivert. International- Antigeron, Arlevert , Avidazine, Cerebral, Cerepar, Cinadil, Cinaren, Cinarin, Cinarizin, Cinarizina MK, Cinarizin, Cinazyn, Cinedil, Cinnageron, Cinnarizina, Cinnarizine Katwijk, Cisaken, Cysten, Diclamina, Fabracin, Folcodal, Inarzin, Medozine, Merron, Nariz, Negaron, Oblant, Perifas, Pyme Cinazin,Sandoz Cinnarizine, Stugeron, Stunarone. Why it is prescribed (Indications) : This medication is an antihistamine, prescribed for the control of nausea and vomiting due to motion sickness. It is also used for vertigo and brain disorder. It blocks the histamine action, which reduces allergy symptoms. When it is not to be taken (Contraindications): Contraindicated in patients with Parkinson's disease, newborns, and hypersensitivity.
Pregnancy Category : A B C D X Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well- controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Dosage & When it is to be taken : Adults: The recommended dose is 25 to 75mg per day in divided doses. How it should be taken : It comes as a tablet to take by mouth, with food. Warnings and Precautions : * Caution should be exercised in patients with history of low blood pressure, during pregnancy and breastfeeding. * It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication. Side Effects : Central Nervous System - Drowsiness, headache, GI upset, unsteadiness, headache, depression dizziness and incoordination. Skin - Rash. Gastrointestinal - Nausea, vomiting, diarrhea or constipation, loss of appetite or increased appetite and stomach pain. Miscellaneous - Weight gain, perspiration or allergic reactions and urinary difficulty or retention. Other Precautions : * Avoid excess dosage. Storage Conditions : Store it at room temperature (25C).
Read more: Cinnarizine (Antigeron) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia http://www.medindia.net/doctors/drug_information/cinnarizine.htm#ixzz2KPwjLemG
Cerebrolysin 101 ml box For the modern, safe and effective treatment of disturbed cerebral functions Effective, non-synthetic treatment for stroke, Alzheimers, dementia Helps sports performance, cognitive function, diabetes Composition Cerebrolysin is a peptide preparation. The solution, ready for injection or infusion, is free of proteins, lipids and antigenic properties. 1ml of Cerebrolysin concentrate as active ingredient in aqueous solution. Route of administration Solution for intramuscular and intravenous injection or intravenous infusion. Pharmacodynamics The efficacy of Cerebrolysin is proven in numerous animal experiments and clinical trials. Cerebrolysin is a brain-specific peptidergic nootropic drug able to affect the central nervous system in a multimodal way. This multimodal action of Cerebrolysin expresses itself as : 1) regulation and improvement of the neuronal metabolism which prevents lactacidoses in hypoxic or ischaemic episodes, 2) modulation of the synaptic plasticity which corresponds to an improvement of behaviour and learning capacity, and 3) a completely unique neurotrophic effect , including neuronal differentiation, guaranteeing full neuronal function and protection against different types of ischaemic and neurotoxin lesions . In Controlled clinical trials Cerebrolysin treatment leads to an improvement in the cognitive performance and mood of patients suffering from Alzheimers disease. Therefore, the amount of care needed by these sufferers decreases. In these patients marked improvement is observed in 61.7% of the Cerebrolysin treated group (as assessed by the Clinical Global Impressions scale CGI ). Another clinical trial in patients with vascular dementia demonstrates enhancement of memory performance in the group receiving Cerebrolysin treatment. An improvement in the global clinical picture is also noticed in this illness. A further study involving patients from nine different disease entities established the effectiveness of Cerebrolysin through the use of 11 psychological tests subjected to a variance analysis. After stroke and craniocerebral truma treatment wit Cerebrolysin leads to an accelerated recovery. Literature on Cerebrolysin is available upon request. Pharmacokinetics cerebrolysin passes through the blood-brain barrier . Up to eight hours after iv administration of Cerebrolysin neurotophic activity can be detected in the human long-lasting effects even after a single iv administarion. Toxicological properties Cerebrolysin is generally well tolerated and possesses an extremely high margin of safety. In human therapeutic dosages this produces almost no toxic symptoms. The toxicological data are listed below. Acute toxicity: after a single iv administration of Cerebrolysin the following LD50 values were observed (14 days observation period) :male rats68ml/kg body weight , female rats 74ml/kg body weight ; dogs, male and female >52.2ml/kg body weight. Chronic toxicity (multiple doses over six months) rats received up to 12.5ml/kg body weight daily for 26 weeks. Only moderate changes in the blood count were observed, dogs ; the highest administrated doses were 9ml/kg body weight daily for 28 days (about 10 times the human therapeutic dosage) and 4.5ml/kg body weight daily for 26 weeks (about five times the human therapeutic dosage): no systemic substance-dependent intolerance reactions were observed . Reproductive toxicity: Cerebrolysin was injected iv to the dams at the highest possible volumes: in no case was an alteration of the gestagenic period observed, in rabbits. Neither embryotoxic nor teratogenic effects nor impairments of embryonic or neonatal developments were found; no influence on the progeny (F1 and F2 generations) was evident. Influence on the fertility and reproductive performance of the parent anilmals potential, effect or carcinogenicity in toxicological tests, neither in vitro nor in vivo.
Indications disturbances of concentration and memory degenerative dementias, including Alzheimers disease vascular demenatias, eg multi-infarct dementia mixed forms of dementia (degenerative and vascular contribution) sequels of stroke (ischaemic and haemorrhagic) posttraumatic or postoperative complaints, eg following cerebral contusion, concussion, or neurosurgical operation.
Contraindications hypersensitivity to one of the components of the drug status epilepticus or grand mal conulsions; an increase in the seizure frequency may be seen in these cases status epilepticus or grand mal conulsions; an increase in the seizure frequency may be seen in these cases severe impairments of renal function
Side effects Cerebrolysin is generally well tolerated. If injected too fast it may cause a moderate heat sensation. In extremely rare cases a hypersensitivity reaction manifested itself as chills, headaches or as slight increase in body temperature the cause of which is probably the hyperresponiveness of the patient. In no case to date has the undesirable effect persisted or proved threatening to the patient.
Warning and precautionary measures Patients with severe renal impairment must be excluded from a Cerebrolysin therapy. Animal experimental data did not show any evidence to teratogenic effects. There is no clinical experience with Cerebrolysin in women. Therefore, unless the potential benefits outweigh any potential risk. Cerebrolysin should not be administered during preguancy and the lactation period.
Interactions The concomitant administration of Cerebrolysin with antidepressive drugs or MAO inhibitors can lead to cumulative effects. In these cases a dose reduction of the antidepressive drug is advisable. Dasage and administration
Cerebrolysin is available in 1ml, 5ml and 10ml ampoules and vials of 30ml and 50ml. Up to 5ml per intramuscular administration, for administration over 5ml an intravenous injection or infusion is advised. Cerebrolysin can also be given diluted in a standard iv solution (eg physiological saline solution, flingers solution, glucose 5%, dextran 40) infused slowly over approximately 20 to 60 minutes, Once daily application of Cerebrolysin for a minimum of 10 to 20 days are recommended. This constitutes a course of therapy. In mild cases 1-5ml, in severe cases 10- 30ml should be applied. The length of the therapy and the individual doses on the age of the patient as well as on the disease. Usually a treatment period of three to four weeks is recommended. Therapy courses can be repeated several times in accordance with the clinical picture of the patient until no further improvement can be observed. Therapy-free intervals should be maintained between courses. In severe cases it is advisable not to interrupt treatment abruptly but to continue with one injection every other day for a period of four weeks. From the above mentioned clinical trials the following daily dosage guits can be deducted dementias 3-50ml daily, in postapplectic deficits and brain injuries 10-50ml daily. Storage Keep in a safe place out the reach of children. Store at room temperature not over 25C, away from light.
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