Cancer Res 1958 Pinkel 853 6
Cancer Res 1958 Pinkel 853 6
8.53
Downloaded from cancerres.aacrjournals.org on December 12, 2014. 1958 American Association for Cancer
Research.
Cancer Research
854
1958
TABLE 1
MECHLORETHAMINE
DOSAGE
Subject
Mouse
Hamster
Rat
Man
Weight
(kg.)
0.018
0.050
0.25
70.0
Surface area
(sq. m.)
0.0075
0.0137
0.045
1.85
Total dose
(mg.)
0.072
0.15
0.5
21-28.0
Total dose/kg
(mg.)
4.0
3.0
2.0
0.3-0.4
Total dose/sq m
(mg.)
96
10.9
11.1
ll.S-15.1
TABLE 2
METHOTREXATE
DOSAGE
Subject
Weight
(kg.)
Mouse
0.018
Rat
0.25
Infant
8.0
Older child
20.0
Adult
70.0
* Generally accepted doses for
Surface area
(sq. m.)
Dose/day(mg.)0.0270.1251.25*2.5*5.0*Dose
kg/day(mg.)1.50.50.150.120.07Dose/sq
m/day(mg.)3.62.83.13.12.7
0.0075
0.045
0.4
0.8
1.85
infants, children, and adults, respectively.
Downloaded from cancerres.aacrjournals.org on December 12, 2014. 1958 American Association for Cancer
Research.
855
SUMMARY
The rationale for the use of body surface area
as the criterion of dosage in anticancer chemo
therapy has been outlined. The similarity in the
dosage per unit of surface area of methotrexate,
mechlorethamine,
actinomycin D, and TSPA for
TABLE 3
6-MERCAPTOPURINE DOSAGE
Surface area
(sq. m.)
0.0075
0.045
0.48
0.4
childAdultWeight(kg.)0.0180.2510.08.020.070.0
0.8
1.85
Dose/day(mg.)0.645.060.025.0
m/day(mg.)8511112568
SubjectMouseRatDogInfantOlder
50.0
68
200.0Dose/kg/day(mg.)40206*8t3tatDose/sq
108
*From dog toxicity data of Philips et al. (15); represents daily dosage for two weeks that
did not cause fatal toxicity.
t 3 mg/kg daily to the nearest 25 mg. is the generally accepted dosage in humans for all
age groups.
TABLE4
ACTINOMYCIN
D DOSAGE
Weight
Subject (kg.)
Mouse
0.018
Child
20.0
Adult
70.0
Surface area
(sq. m.)
0.0075
0.8
1.85
Total dose
(Mg.)
18
1600-1920
5250
(M.)
Total dose/sq
(Mg.)
1000
80-96
75
2400
2000-2400
2840
Total
doseAg
TABLE5
TRIETHYLENETHIOPHOSPHORAMIDE
(TSPA)DOSAGE
Subject
Mouse
Rat
Man
Weight
(kg.)
0.018
0.25
70.0
Surface area
(sq. m.)
0.0075
0.045
1.85
Dose/day
(mg.)
0.036
0.125-0.25
5-10
DoseAg/day
(mg.)
2
0.5-1.0
0.07-0.14
Dose/sq m/day
(mg.)
4.8
2.8-5.6
2.7-5.4
Downloaded from cancerres.aacrjournals.org on December 12, 2014. 1958 American Association for Cancer
Research.
856
Cancer Research
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Research.
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