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03 Adaptive Immune System
03 Adaptive Immune System
IgM serves as BCR for antigen attachment; produced in early stages of plasma
cell response
IgG most abundant; produces in large quantity when body exposed to same
antigen
IgE protect against parasitic worms; antibody mediator for common allergic
responses ie. Hay fever , asthma, hives
IgA found in secretions of digestive, respiratory, urogenital system, milk and
tears
IgD present on surface of B cells
B cells differentiate into two cell types plasma cells and memory cells
o Plasma cells then switch to produce IgG antibodies which are secreted rather
remaining membrane bound
o Memory Cells
Small portion of B lymphocytes becine memory cells, which do not
participate in current immune attack against antigen but remains
dormant and expand specific clones
Memory cells are primed and ready for immediate action when person
is reexposed to same antigen
3. Role of antibodies
Antibodies cannot directly destroy foreign organisms but exert protective influence
by physically hindering antigens ( amplifying innate immune response)
Antibodies physically hinder antigens through neutralization and
agglutination.
1. Neutralization
o Antibodies combine with bacterial toxin, preventing harmful chemicals from
interacting with susceptible cells
o Antibody neutralize some viruses by binding with their surface antigens,
preventing these viruses from entering cells
2. Agglutination
o Multiple antibodies cross-link numerous antigen molecules into chains/ lattice of
antigen-antibody complexes
o Foreign cells( bacteria, mismatched transfused rbc) will then bind together in a
clump
o Sometimes, antigen-antibody complex which involve soluble antigens(tetanus
toxin) forms lattice that is so large that it precipitates out of solution
Antibodies amplify innate immune responses
o Mark foreign materials as targets for actual destruction by complement
system, phagocytes or natural killer cells while enhancing the activity of
these other defense systems
Activation of complement system
Antigen bind with antibody, receptors on tail portion of antibody
bind with and activate C1.
Secondary response: longer-lasting, rapid and more potent response by longlived memory cells in contact with same antigen
o Important in preventing and minimizing overt infection on subsequent
exposure to same microbes, forming long term immunity against specific
disease
Formation of memory cells occur through the person either actually having the
disease/ being vaccinized already
Active Immunity
1. Types of T cells:
Classified by function : Cytotoxic T cells , helper T cells, regulatory T cells
Classified by specific membrane protein type: CD8+ T cells, CD4+ T cells, CD4+CD25+
T cells
i.
Cytotoxic (killer) T cells
Destroy invaded hosts cells which bear foreign antigen ( eg: body cells invaded by
virus, cancer cells that have mutated proteins)
TCR associated with coreceptors designated CD8, which are inserted into plasma
membrane as these cells pass through the thymus.
ii.
Helper T cells
Do not directly participate in immune destruction of pathogens
Turn on and activate lymphocytes and macrophages
Makes up 60-80% of circulating T cells
Can be subdivided into two subsets T helper 1 (TH1) , T helper 2(TH2)
o TH1
Rally cell mediated ( killer T cell) response for viruses
activated by IL-12
o
TH2
iii.
Activated by IL-4
TH17(new subclass)
Produces IL-17.
IL-6 from macrophages guide their production
Promote inflammation; effector molecules in development of
inflammatory autoimmune disease
b. IL-2 T-cell growth factor which increases activity of T killer cells and other
helper T cells
IL-1 secreted by macrophage not only enhances activity of B and T cells
but alsmo stimulate secretion of IL-2 by activated helper T cells
c. Chemicals act as chemotaxin luring more neutrophils and macrophage-to-be
d. Macrophage-migration inhibition factor released once macrophages attracted
to area.
Keeps large phagocytic cells by inhibiting outward migration
Resulting more attraction of macrophages in injured area
This factor also makes macrophages phagocytic power [ angry
macrophage important in defending against bacteria that causes TB
Dendritic cells abundant in the skin and mucosal lining of lungs and
digestive tracts
After exposure to appropriate antigens, dendritic cells migrate
through lymphatic system to lymph nodes and activate T cells
Mechanism:
1. Dendritic cells
phagocytize
invading bacteria :
2. Endocytic vesicle
containing engulfed
bacteria fuses with
lysosome, which
break down
bacteriums protein
into antigenic
peptides
3. Each antigenic
peptide then binds
to newly
synthesized MHC
molecule within the endoplasmic reticulum/Golgi complex
4. Peptides load onto MHC through organelle within APC ( compartment for
peptide loading )
5. MHC then transport bound antigen to cell surface, where it is presented to
pass T lymphocytes
6. When helper T cells bind to APC, APC secrete cytokines IL-1 and TNF which
activates T cells
7. Activated T cells then secrete cytokines in autocrine manner to stimulate
clonal expansion of the particular helped T cell which acts in a paracrine
manner on adjacent B cells, cytotoxic T cells and NK cells enhancing their
ability
MHC