Scribd Logo
Upload

Welcome to Scribd!

  • Articole

    Uploaded by

    alinavs
    42 views9 pages
    aricolelelelbune

    Original Title

    articole

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    aricolelelelbune

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    42 views9 pages

    Articole

    Uploaded by

    alinavs
    aricolelelelbune

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    of 9

    Tu YS, Kang XL, Zhou JG, Lv XF, Tang YB, Guan YY.

    Involvement of Chk1-Cdc25A-cyclin
    A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple
    myeloma cells. Eur J Pharmacol 2011; 670: 356364.
    Mohammed A, Qian L, Janakiram NB, Lightfoot S, Steele VE, Rao CV. Atorvastatin delays
    progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/
    LSL-KrasG12D/ mice. Int J Cancer 2012; 131: 19511962.
    13. Pelaia G, Gallelli L, Renda T, Fratto D, Falcone D, Caraglia M et al. Effects of statins and
    farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in nonsmall
    lung cancer cells. Cell Prolif 2012; 45: 557565
    Riganti C, Doublier S, Costamagna C, Aldieri E, Pescarmona G, Ghigo D et al. Activation of
    nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin
    cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol 2008; 74: 476484.
    Maeda A, Yano T, Itoh Y, et al. Down-regulation of RhoA is involved in the cytotoxic
    action of lipophilic statins in HepG2 cells. Atherosclerosis 2010; 208:
    112118.
    Su Y, Xu Y, Sun YM, et al. Comparison of the effects of simvastatin versus atorvastatin
    on oxidative stress in patients with type 2 diabetes mellitus. J Cardiovasc
    Pharmacol 2010; 55: 2125.
    Koh KK, Sakuma I, Quon MJ. Differential metabolic effects of distinct statins.
    Atherosclerosis 2011; 215: 18
    Shimoyama S (2011) Statins are logical candidates for overcoming limitations of
    targeting therapies on malignancy: their potential application to gastrointestinal
    cancers. Cancer Chemother Pharmacol 67: 729739.
    4. Papadopoulos G, Delakas D, Nakopoulou L, Kassimatis T (2011) Statins and
    prostate cancer: molecular and clinical aspects. Eur J Cancer 47: 819830.

    The 3-hydroxy-3-methylglutaryl-coenzyme A
    reductase inhibitors,
    simvastatin, lovastatin and mevastatin inhibit
    proliferation and
    invasion of melanoma cells
    Sharon A Glynn*1,2, Dermot O'Sullivan1, Alex J Eustace1,
    Martin Clynes1 and
    Norma O'Donovan1
    Simvastatin inhibition of mevalonate pathway induces apoptosis in
    human
    breast cancer cells via activation of JNK/CHOP/DR5 signaling
    pathway
    Archana Gopalan

    a,1,

    Weiping Yu

    b,1,

    Bob G. Sanders b, Kimberly Kline a,

    C. Spampanato, M.S. De, M. Sarnataro, E. Giordano, M. Zanfardino, S. Baiano, M.


    Carten, F. Morelli, Simvastatin inhibits cancer cell growth by inducing
    apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene
    expression, Int. J. Oncol. 40 (2012) 935941.

    N. Ghosh-Choudhury, C.C. Mandal, N. Ghosh-Choudhury, G. Choudhury,


    Simvastatin induces derepression of PTEN expression via NFkappaB to
    inhibit breast cancer cell growth, Cell. Signal. 22 (2010) 749758.
    [12] S.T. Kochuparambil, B. Al-Husein, A. Goc, S. Soliman, P.R. Somanath, Anticancer
    efficacy of simvastatin on prostate cancer cells and tumor xenografts is
    associated with inhibition of Akt and reduced prostate-specific antigen
    expression, J. Pharmacol. Exp. Ther. 336 (2011) 496505

    M. Thurnher, O. Nussbaumer, G. Gruenbacher, Novel aspects of mevalonate


    pathway inhibitors as antitumor agents, Clin. Cancer Res. 18 (2012) 3524
    3531.

    E.R. Garwood, A.S. Kumar, F.L. Baehner, D.H. Moore, A. Au, N. Hylton, C.I.
    Flowers, J. Garber, B.A. Lesnikoski, E.S. Hwang, O. Olopade, E.R. Port, M.
    Campbell, L.J. Esserman, Fluvastatin reduces proliferation and increases
    apoptosis in women with high grade breast cancer, Breast Cancer Res. Treat.
    119 (2010) 137144.
    [18] Y.K. Chae, E.R. Garwood, M.E. Valsecchi, J. Kim, A.L. Bianchi, D. Khemasuwan, A.
    Desai, W. Tester, Reduced risk of breast cancer recurrence in patients using
    ACE inhibitors, ARBs, and/or statins, Cancer Invest. 29 (2011) 585593.

    K.E. Hwang, K.S. Na, D.S. Park, K.H. Choi, B.R. Kim, H. Shim, E.T. Jeong, H.R. Kim,
    Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt
    signaling dependent down-regulation of survivin, Invest. New Drugs 29 (2010)
    945952.

    Inhibition of Lung Cancer


    Growth: ATP Citrate Lyase
    Knockdown and Statin Treatment
    Leads to Dual Blockade of
    Mitogen-Activated Protein
    Kinase (MAPK) and
    Phosphatidylinositol-3-Kinase
    (PI3K)/AKT Pathways
    JUN-ICHI HANAI,1,2 NATHANIEL DORO,1 ATSUO T. SASAKI,4,5 SUSUMU
    KOBAYASHI,3
    LEWIS C. CANTLEY,4,5 PANKAJ SETH,1
    AND VIKAS P. SUKHATME1,2,3*

    Inhibition of Lung Cancer


    Growth: ATP Citrate Lyase
    Knockdown and Statin Treatment
    Leads to Dual Blockade of
    Mitogen-Activated Protein
    Kinase (MAPK) and
    Phosphatidylinositol-3-Kinase
    (PI3K)/AKT Pathways
    JUN-ICHI HANAI,1,2 NATHANIEL DORO,1 ATSUO T. SASAKI,4,5 SUSUMU
    KOBAYASHI,3
    LEWIS C. CANTLEY,4,5 PANKAJ SETH,1
    AND VIKAS P. SUKHATME1,2,3*

    Statins as modulators of colon cancer cells induced cytokine


    secretion by
    human PBMC
    Michael Bergman

    a,c,

    Hertzel Salman

    a,c,

    Meir Djaldetti

    b,c,

    , Hanna Bessler b,c

    Statin therapy attenuates growth and malignant potential


    of human
    esophageal adenocarcinoma cells
    Miral R. Sadaria, MD, Amy E. Reppert, MD, Jessica A. Yu, MD, Xianzhong Meng, MD,
    PhD,
    David A. Fullerton, MD, T. Brett Reece, MD, and Michael J. Weyant, MD

    Simvastatin inhibition of mevalonate pathway induces apoptosis in


    human
    breast cancer cells via activation of JNK/CHOP/DR5 signaling
    pathway
    Archana Gopalan

    a,1,

    Weiping Yu

    b,1,

    Bob G. Sanders b, Kimberly Kline a,

    Simvastatin Induces Apoptosis in Castrate Resistant


    Prostate
    Cancer Cells by Deregulating Nuclear Factor-_B Pathway
    Yong Hyun Park, Su Yeon Seo, Eunhye Lee, Ja Hyeon Ku, Hyeon Hoe Kim* and
    Cheol Kwak*

    Effects of statins and farnesyl transferase inhibitors on ERK


    phosphorylation,
    apoptosis and cell viability in non-small lung cancer cells
    G. Pelaia*, L. Gallelli, T. Renda*, D. Fratto, D. Falcone, M. Caraglia, M. T. Busceti*, R.
    Terracciano,
    A. Vatrella, R. Maselli* and R. Savino

    Statins and autoimmunity


    Saakshi Khattri Gisele Zandman-Goddard

    Regulation of mevalonate metabolism in cancer and immune cells


    Q13 Martin

    Thurnher , Georg Gruenbacher, Oliver Nussbaumer

    Targeting protein prenylation for


    cancer therapy
    Norbert Berndt*, Andrew D. Hamilton and Sad M. Sebti*

    Pleiotropic Effects of Statins


    Basic Research and Clinical Perspectives
    Qian Zhou, MD; James K. Liao, MD

    Anti-atherosclerotic mechanisms of statin therapy Andrea


    Babelova1, Daniel G Sedding2 and Ralf P Brandes1

    Targeting tumor cell metabolism with statins


    JW Clendening and LZ Penn

    Receptor Mediated Tumor Targeting: An Emerging Approach for


    Cancer
    Therapy
    Chandana Mohanty1, Manasi Das1, Jagat R. Kanwar2 and Sanjeeb K. Sahoo1,*

    Deciphering the signaling networks underlying


    simvastatin-induced apoptosis in human cancer
    cells:
    evidence for non-canonical activation of RhoA and
    Rac1 GTPases
    Y Zhu1,2, PJ Casey3,4, AP Kumar5,6,7,8 and S Pervaiz*,1,2,4,6,8,9

    Reduction of lung metastasis, cell


    invasion, and
    adhesion in mouse melanoma by
    statin-induced
    blockade of the Rho/Rho-associated
    coiled-coilcontaining
    protein kinase pathway

    Yasuhiro Kidera1,2, Masanobu Tsubaki1, Yuzuru Yamazoe1,2, Kaori Shoji3, Haruyuki


    Nakamura3, Mitsuhiko Ogaki3,
    Takao Satou4, Tatsuki Itoh4, Misako Isozaki1,2, Junichi Kaneko1, Yoshihiro Tanimori1,2,
    Masashi Yanae1,5,
    Shozo Nishida1*

    Mini-review

    Molecular mechanisms underlying chronic inflammation-associated


    cancers

    Yongzhong Wua, Smitha Antony a, Jennifer L. Meitzler a, James H. Doroshow

    a,b,

    Combating oxidative stress in


    vascular disease: NADPH oxidases as
    therapeutic targets
    *Grant R. Drummond, *Stavros Selemidis, Kathy K. Griendling and *Christopher G.
    Sobey

    Simvastatin inhibits osteoclast differentiation by


    scavenging
    reactive oxygen species
    Ho-Jin Moon1, Sung Eun Kim1, Young Pil Yun1,
    Yu-Shik Hwang1, Jae Beum Bang2,
    Jae-Hong Park3,4* and Il Keun Kwon1,4*

    Far and Wide Pleiotropic Effects of Statins


    A. Rohilla1* and MU. Khan2

    Effects of statin use on total oxidant


    and antoxidant
    capacity and ceruloplasmin activity

    Statins: protectors or pretenders


    in prostate cancer? Hyeongsun Moon , Michelle
    1

    M. Hill1, Matthew J. Roberts2,3,4, Robert A. Gardiner2,3, and Andrew J.


    Brown5

    Reduction of lung metastasis, cell


    invasion, and
    adhesion in mouse melanoma by
    statin-induced
    blockade of the Rho/Rho-associated
    coiled-coilcontaining
    protein kinase pathway
    Yasuhiro Kidera1,2, Masanobu Tsubaki1, Yuzuru Yamazoe1,2, Kaori Shoji3, Haruyuki
    Nakamura3, Mitsuhiko Ogaki3,
    Takao Satou4, Tatsuki Itoh4, Misako Isozaki1,2, Junichi Kaneko1, Yoshihiro Tanimori1,2,
    Masashi Yanae1,5,
    Shozo Nishida1

    Mechanisms for the anti-inflammatory effects of statins


    De-xiu Bu, Gabriel Griffin and Andrew H. Lichtman

    Antioxidant, antinociceptive and anti-inflammatory


    activities
    of atorvastatin and rosuvastatin in various experimental
    models
    Mahesh M. Ghaisas Prasad R. Dandawate
    Suyash A. Zawar Yogesh S. Ahire
    Santosh P. Gandhi

    A Clinical Review of Statins and Cancer:


    Helpful or Harmful?

    Statins:
    perspectives
    in
    Cancer

    Therapeutics
    Laurent
    CORCOS
    &
    Catherine
    LE
    JOSSIC--CORCOS

    A Clinical Evaluation of Statin Pleiotropy:


    Statins
    Selectively and Dose-Dependently Reduce
    Vascular
    Inflammation
    Evelien van der Meij1, Giel G. Koning2, Patrick W. Vriens2, Marcel F. Peeters5, C. Arnoud
    Meijer1,
    Kim E. Kortekaas1,4, Ronald L. Dalman4, J. Hajo van Bockel1, Roeland Hanemaaijer3, Teake
    Kooistra3,
    Robert Kleemann3, Jan H. N. Lindeman1*

    Statins as Regulators of Redox State


    in the Vascular Endothelium:
    Beyond Lipid Lowering

    Marios Margaritis, Keith M. Channon, and Charalambos Antoniades


    Abstract

    Am J Cancer Res 2011;1(4):542-561


    www.ajcr.us /ISSN:2156-6976/ajcr0000049

    Review Article
    Statins and prostate cancer: role of cholesterol
    inhibition
    vs. prevention of small GTP-binding proteins
    Mohana Roy1, Hsing-Jien Kung2, Paramita M. Ghosh1,2

    Overcoming multidrug-resistance in cancer: Statins offer a logical


    candidate
    Narendra G. Mehta

    a,*,

    Monica Mehta

    b,1

    Atorvastatin sensitizes human non-small cell lung carcinomas to


    carboplatin via
    suppression of AKT activation and upregulation of TIMP-1

    Inhibition of Autophagy Enhances Anticancer Effects of


    Atorvastatin in Digestive Malignancies
    Pei-Ming Yang1, Yuan-Ling Liu1, Yi-Chu Lin1, Chia-Tung Shun2, Ming-Shiang Wu3, and Ching-Chow Chen1

    You might also like