Hormone Replacement Therapy
Hormone Replacement Therapy
these pulsates are converted in the liver (within 20 minutes) to Insulinlike Growth Factor Type I (IGF-1). Although IGF-1 is not insulin, it acts like
insulin in that it promotes glucose transfer through cell membranes into the
cell. More importantly, IGF-1 elicits most of the effects associated with
growth hormone. It is measured in the blood, and this is significant because
it enables us to measure the amount of growth hormone currently being
released. Lastly, many factors affect the ability of the body to release hGH
and form IGF-1. These factors include physical and emoional stress,
chronic liver dysfunction, poor diet and genetic predisposition. Other factors
leading to decrease of hGH release are obesity, zinc and magnesium
deficiency, or an increase in blood sugar and/or insulin levels. On the
other hand, factors increasing hGH include calorie restriction,
testosterone or estrogen levels, high doses of amino acids: LArgentine, Glutamate, Lysine, intense, sustained exercise, as well as
an increase in calcium.
HISTORY OF hGH
Growth Hormone was first discovered in 1912 by Dr. Harvey Cussing, but
was first isolated from human and monkey cadavers through glandular
extraction in 1956. Only two years later it was being used to treat dwarf
children by injection. In 1989 came the landmark double blind study by
Dr. Daniel Rudman. The results of this study conclusively showed that with
the use of GH, age reversal was possible. This study included adult men
who had measured deficiencies in growth hormones. These men were all
between the ages of 61 and 73. They were injected with GH made from
recombinant DNA synthesis. In 1990, Dr. Rudman's results were reported in
the prestigious New England Journal of Medicine.
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SECRETAGOGUES
Funny name: secretagogue (pronounced se ere' ta gog). A secretagogue is
a natural polyamino acid chain that is postulated to cause the pituitary
to release growth hormone. It is the precoursor to hGH. While hGH
causes the body to act as if the pituitary has released growth hormone,
a secretagogue actually causes the release of it. So with a
secretagogue, the bodies own natural processes produce growth
hormones. They do not act as growth hormones at all; they stimulate
the pituitary gland to secrete growth hormone.
AMINO ACIDS
Amino acids are also known in this field as GH Provocateurs. They provoke
the stimulation of growth hormone. They are the least expensive of the
GHRH Factors. To produce sufficient amounts of GH, one consumes
relatively large doses of amino acids. These particular amino Acids
include Glutamine, Arginine, Lysine and Ornithine.
GLUTAMINE
Glutamine is the most abundant amino acid in the body. It is a condiional
amino acid, meaning that the body may not be able to synthesize it
when under stress. It causes GH secretion as well. Traditionally it has
been used in helping strengthen the immune system. Normal anti-aging
intake is 50mg to 1gm for 2 times a day. Glutamine is a neurotransmitter
in the brain. It is essential for proper brain function or it help to remove
ammonia from the brain and lung. It is vital for maintaining proper immune
function, kidneys, pancreas, bladder and liver.
In a higher quantity, it becomes one of our body's most powerful antioxidant.
Many people, especially those in weight training, add this amino acid to
common protein drink due to its benefit in muscle metabolism effect. In such
case, supplementation of 2-3gm/day is quite common. For those who plan
to take extra Glutamine, it is best if the dosage divide the doses
through out the day, can be up to 4 servings/day. Over
supplementation of glutamine will contribute to ammonia load. Free
form of L-Glutamine is known to produce a strong anticatabolic effect by
athletes, which neutralizes the cortisol that accompanies the strenuous
exercises.
Other ingredient that potentate Glutamine action include:
A. Glysine - help to induce the cell-volumizing effect.
B. Alanine - help preserve muscle glutamine concentrations by
converting it to blood glucose during calorie restriction.
C. AKG (2-4 gram / day is common use for body builders). This is a
direct precursor to the synthesis of glutamine in the body
Anti aging benefit of glutamine are many, including -
It may also boost the function of the brain as the brain tissue contains 6
times more DHEA than any other tissue in the body. As far as anti aging is
concern, effects may come about by increasing IGF-1 levels. Furthermore,
DHEA is an inexpensive alternative to GH. Dosage range is between 2550mg per day. DHEA levels should be measured intermittently and a
resting cycle should periodically be observed.
MELOTONIN
Melotonin is a hormone with powerful antioxidant properties. It is reportedly
an immune booster, cancer fighter, heart helper mood elevator, and natural
sleeping agent. The organ, which secretes melotonin, is the pineal gland, the
timekeeper of the brain and that that controls our circadian rhythms. Dosage
varies from person to person. Low dosages of .3mg to I mg. can reduce the
time to fall asleep as well as increase the quality of sleep. Some people
require as much as 60mg to before it begins working. Normal
recommended starting dosage is 0.5mg. to I mg. before bedtime. If you
decide to increase the dosage do so up to 5-1 Omg per day as needed.
This is contraindicated in: pregnant or nursing mother, children,
women trying to conceive, people who are on prescription steroids or
who have mental illness, severe allergies, or immune system cancers
such as lymphoma.
IGF-1 REPLACEMENT
With IGT-1, science is attempting to manipulate IGF-1 levels, which would
then produce the responses needed to affect age reversal. At this particular
time, work done in the field on IGF-1 is so new there is not much to report. It
will be years before clinical trials are completed. Another problem to be
solved before it is approved however is how the FDA will classify it since it is
neither a pharmaceutical nor a supplement. With such questions yet to be
resolved one may wonder where is the science of growth hormone is
headed. Ideally, it looks as if science will soon discover a small, cheap, safe
pili that a person could take every day to raise hGH levels - a kind of antiaging aspirin. This would be the ultimate secretagogue. Extensive clinical
trials are already underway.
Exercise and diet both promote the control of insulin. Not surprisingly, hGH
dosage is decreased with vigorous exercise. In addition, hGH can be
enhanced with supplements such as Chromium Piccolinate which
lowers circulating insulin and blood sugar. Finally, a Multi-hormonal
Replacement enhancement such as estrogen, progesterone, DHEA,
testosterone, and melotonin can give an added boost to the secretion of
hGH. With regards to hGH Diet enhancement, it is recommend that 5060% of food in-take should consist of the carbohydrates found in fruits
and vegetables. It is highly recommended that one takes complex
carbohydrates, such as fruits and vegetables, as compared to rice and
potato. Complex carbohydrates break down slowly, and therefore
restrict abrupt insulin rise in blood. Protein should account for 20-30%
and fat 10-20% of the remainder of food consumption. These
percentages of food intake represent the necessary amounts to cause
hGH to be released. Permit us a word on hGH production and exercise.
Current studies are not conclusive as of yet. Test results with athletes whose
iniial IGF-1 were near optimal contribute to our conclusion that hGH will not
be over- stimulated in people who have close to optimal hGH levels. It is
nonetheless, it is most prudent to check IGF-1 levels every 6 months. IGF-1
levels which are below normal and have been restored to normal levels, it is
advisable to back off any rigorous pace set to increase these level.