Walker Et Al-2015-American Journal of Physical Anthropology
Walker Et Al-2015-American Journal of Physical Anthropology
ABSTRACT
Treponematosis is a syndrome of chronic
infectious diseases. There has been much debate on its
origins and spread, particularly with regard to venereal
syphilis, an unsightly and debilitating disease in preantibiotic populations. The osteological analysis of 5,387
individuals excavated by Museum of London Archaeology from the medieval burial ground of St. Mary Spital
in London (dated c 11201539) provided an unprecedented opportunity to investigate the nature and prevalence of disease over a period of time. Twenty-five
individuals were found with suspected treponematosis,
originating from all but the earliest period of the burial
91
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D. WALKER ET AL.
Dates
c. 11201200
c. 12001250
c. 12501400
c. 14001539
93
shafts. Demographic details of all individuals with treponematosis were analyzed by age, sex, and period.
The statistical significance of results was established
through v2 tests, employing Yates correction for small
samples, with the chosen significance level being 0.05.
RESULTS
Descriptions of Selected Individuals
Details of the pathological changes of all 25 skeletons
believed to be affected by treponematosis are located in
the project archive. Descriptions of a representative
selection of individuals are included below, together with
supporting images.
Period 15 (c. 12001250). Context [22251], 2635
years of age at death. The skull of this individual was
not preserved due to truncation of the burial, but there
were extensive pathological changes to the appendicular
skeleton. There was a thick layer of periosteal new bone
on the posterior surface of the right acromion. The
medial part of the right clavicle was covered circumferentially in a fine layer of woven periosteal new bone,
while the inferior and posterior aspects of the midshaft
and the superior aspect of the lateral part were similarly
affected. The anterior surface of the medial part exhibited a lytic lesion (longitudinal axis length 30.6 mm)
with ragged margins, which extended through the cortex
to the anterior margin of the proximal facet. In the left
clavicle, the diaphysis was swollen with a surface of
porotic periosteal new bone punctured by two lytic
lesions with irregular margins, one on the medial part
(length 14.9 mm, width 15 mm), and one on the midshaft (length 35.7 mm, width 17.9 mm). Woven periosteal new bone surrounded these lesions as well as the
anterior and posterior surfaces of the manubrium.
The distal third of the diaphyses of the humeri were
covered in periosteal new bone and the proximal third
shaft of the left bone had a deep lytic lesion (length
26.6 mm, width 12 mm) penetrating the cortex (Fig. 1).
The proximal end of the left ulna, including the articular
surface of the olecranon, was swollen and covered in a
thick layer of periosteal new bone. There was a deep
lytic lesion below the trochlear notch. The diaphyses of
the second to fourth right metacarpals were also covered
in periosteal new bone.
In the lower limb bones, the right femur displayed
fusiform enlargement of the distal third of the shaft.
Both this and the left tibial diaphysis were covered by
thick layers of woven periosteal new bone formation.
The left tibial diaphysis also had four large lytic lesions,
the largest being 53.4 mm long and 34.7 mm wide.
There was periosteal new bone on the shaft of the left
fibula, and on the diaphyses of the second and third
right metatarsals. Although the skull of this individual
was not present, the combination of diffuse gross deposits of periosteal new bone and gummatous lesions were
characteristic of treponemal infection (Hackett, 1975,
238).
Period 16 (c. 12501400). Context [10566], Male 2635
years of age at death. This individual exhibited a number of bone changes in the axial and appendicular skeleton. In addition to dense supraorbital micro-porosity,
there was an erosive lesion adjacent to the supra-orbital
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D. WALKER ET AL.
95
Total
Adults
Females
Males
Intermediate sex
Undetermined sex
Subadults
Affected
(%)
5387
4360
1883
2237
205
35
1027
25
22
8
11
0
3
3
0.5
0.5
0.4
0.5
8.6
0.3
1825 years
2635 years
3645 years
46 years
Male
Affected
(%)
Affected
(%)
428
716
467
211
2
4
2
0
0.5
0.6
0.4
0
481
752
700
222
2
6
3
0
0.4
0.8
0.4
0
611 years
1217 years
Affected
(%)
348
544
1
2
0.3
0.4
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D. WALKER ET AL.
TABLE 6. Crude prevalence of treponematosis in the attritional
burial ground by sex and period
Female
15
16
17
Affected
(%)
510
1392
526
2
5
18
0.4
0.4
3.4
DISCUSSION
The aim of this work was to investigate the evidence
for pre-Columbian treponematosis in London and
explore the possibility that venereal syphilis may have
been present prior to the 15th century. We also examined evidence for changes in the expression of the disease over time and between the sexes.
Documentary evidence from Europe in the first half of
the 16th century reports a rapidly spreading, highly virAmerican Journal of Physical Anthropology
Male
Affected
(%)
Affected
(%)
167
474
164
0
1
7
0.0
0.2
4.3
219
628
239
1
4
6
0.5
0.6
2.5
97
Fig. 6. Percentage distribution of affected bones (n 5 201) in individuals with treponematosis from St. Mary Spital (skeletons
with paired bones where both right and left sides were affected were counted only once).
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D. WALKER ET AL.
Fig. 8. Distribution of lesions in females with treponematosis (n 5 8) (gray infill < 50% of the bones or bone segments have
lesions, black infill 50% or more of the bones or bone segments
have lesions).
Fig. 9. Distribution of lesions in individuals with treponematosis from periods 15 and 16 (c. 12001400) (n 5 7) (gray
infill < 50% of the bones or bone segments have lesions, black
infill 50% or more of the bones or bone segments have lesions).
99
Fig. 10. Distribution of lesions in individuals with treponematosis from period 17 (c. 14001539) (n 5 18) (gray infill < 50%
of the bones or bone segments have lesions, black infill 50% or
more of the bones or bone segments have lesions).
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D. WALKER ET AL.
ACKNOWLEDGMENTS
We wish to thank City of London Archaeological Trust,
together with London Archaeologist magazine, for providing a grant for this work. The Spitalfields Project was
funded principally by the Spitalfields Development Group
(a subsidiary of Hammerson Plc.). A large number of present and past employees of Museum of London Archaeology
were involved in aspects of the excavation and postexcavation work. Chris Thomas was in overall charge of the project, and we must acknowledge his work together with
numerous field archaeologists involved in the excavations
at Spitalfields Market. The skeletal remains from St. Mary
Spital were analyzed by Brian Connell, Amy Gray Jones
(University of Chester), Rebecca Redfern, and Don Walker.
David Bowsher provided assistance in the production of
the original grant application. Judit Peresztegi designed
the graphs and skeletal diagrams and Andy Chopping produced the photographic images. Finally, the authors would
like to acknowledge the advice and encouragement provided by the late Don Ortner.
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