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NOVALGIN
NOVALGIN
Generic Name
Analgin
About Generic
Contents
Metamizole sodium.
Indications
Mechanism of
Action
This pyrazolone group containing NSAID has potent analgesic, antipyretic and
moderate anti inflammatory activity. It blocks the synthesis of Pyrogens. It also
reduces Prostaglandin D&E synthesis by Cyclo-oxigenase enzim inhibition. These
peripheral interaction are the cause for its analgesic and antipyretic activity. There is
a small fraction of reduction in sensitivity of nerve endings due to this decrese
prostaglandin synthesis. Centrally it stimulate the synthesis of beta endorphin it
cause the analgesic action on visceral pain. In the muscles of biliary tract, urinary
tract, and in uterus it has some spasmolytic activity.
Pharmacokinetic
Onset of Action
30 to 60 minutes
Overdosage
Warnings
*Excretion of a harmless metabolite may cause a red colouration of the urine, which
disappears on discontinuation of treatment.
*Pain-relieving drugs must not be used over prolonged periods of time or in high
doses without the doctors or dentists advice.
Special
Precautions
( Prior to its use,
patients should
consult their doctor)
- Patients who suffer from preexisting defective blood formation (eg, from cytostatic
therapy) should take
Novalgin only under medical supervision.
- Patients suffering from bronchial asthma or chronic respiratory tract infections
(especially when
combined with hay fever-like manifestations), and patients with hypersensitivity to
pain-relieving and
antirheumatic drugs of any kind are at risk of attacks of asthma or shock (analgesic
asthma/analgesic
intolerance) from the administration of Novalgin.
- Patients who react to alcoholic beverages, even to small amounts, with sneezing,
lacrimation and
pronounced reddening of the face, as well as to patients who are allergic (cutaneou
reactions, itching,
urticaria) to other substances (eg, foodstuffs, furs, hair dyes and preservative
agents).
- Novalgin is not recommended to be taken continuously in long periods of time as
it may lead to agranulocytosis, neuropathy (reversible if Novalgin is discontinued).
Use in pregnancy: During pregnancy, especially in the first 3 months and the last 6
weeks, Novalgin must
not be used except upon the instructions of the doctor.
Use in children: Novalgin tablet is not suitable for the treatment of children <15
years.
Because of the possibility of interference with renal function,
Novalgin should not be
given to infants <3 months or <5 kg body weight, unless there is
a compelling indication.
Medical supervision is also recommended for infants >3 months
and for young children.
Adverse Drug
Reactions
Storage
Drug Classification G
Presentation/Packi Tab 500 mg (oblong) x 100's, 500's.
ng
Syrup 50 mg/mL x 60 mL x 1's.
Drops 500 mg/mL x 10 mL x 1's.
Amp 500 mg/mL x 2 mL x 5's.