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Technical Training
on
4008 Dialysis Machine
Shanghai, April 2002
Hotin
May 2001
Dialyzer Membrane
Fresenius Medical Care
May 2001
May 2001
PORE
PORESIZE
SIZEisisdependant
dependanton
onthe
thetype
type
ofofmembrane;
membrane;
HF Dialyser:
Pore size ~ 0.3nm
LF Dialyser:
Pore size ~ 0.1nm
May 2001
Venous Pressure
Measurement
Blood out
Venous
Bubble Catcher
Dialysate in
Dialyzer
Dialysate out
Venous Clamp
Blood in
Blood Pump
Arterial Pressure
Measurement
HEMODIALYSIS
HD
j:\sd\ch\folien\tpf_nma\hd_arm_e.cdr
Heater
Hemofilter
Blood leak
detector
cleared blood
Filtr. pump
Blood
Sub. pump
Blood pump
Hemofiltration HF
Filtrate
Substituate
Fluid balance
May 2001
SD / TRAINING CENTER SCHWEINFURT
j:\sd\ch\folien\tpf_nma\hf_e.cdr
Heater
Hemofilter
cleared blood
Blood leak
detector
Filtr. pump
Blood
Sub. pump
Blood pump
Hemodiafiltration HDF
Filtrate
Substituate
Hemodiafiltration is a combination of hemodialysis and hemofiltration to take advantage of the benefits of hemodialysis - high clearance of small-molecular substances
and hemofiltration - good clearance with middle-molecular substances.
Fluid balance
May 2001
SD / TRAINING CENTER SCHWEINFURT
j:\sd\ch\folien\tpf_nma\hdf_e.cdr
200
conventional Hemodialysis
Hemofiltration
Hemodiafiltration with Polysulfone membrane (Fresenius)
150
100
50
102
103
104
Inulin
Urea
Creatinin
Vit. B12
105
Albumin
Molecularweight
(Dalton)
2-Microglobulin
May 2001
SD / TRAINING CENTER SCHWEINFURT
May 2001
May 2001
May 2001
May 2001
Main Components
Monitor
- Control Unit
Modules
- Extracorporeal
Blood Circuit
Hydraulics - Preparation of
Dialysis Fluid
May 2001
Monitor
Extracorporeal
Blood Circuit
Hydraulics
May 2001
Operating Elements
Displays
Alarms
Blood Pump
Heparin Pump
Air Detector
Preparation
Preparation of
of Dialysis
Dialysis Fluid
Fluid
-- Mixing
Mixing
-- Heating
Heating
-- Degassing
Degassing
Transport
Transport of
of dialysis
dialysis Fluid
Fluid
Fluid
Fluid Balance
Balance &
& Ultrafiltration
Ultrafiltration
Electronic Compartment
Fresenius Medical Care
May 2001
Blood Pump
Fresenius Medical Care
May 2001
Heparin Pump
Fresenius Medical Care
Anticoagulation:
To prevent blood clotting in the
extracorporeal blood circuit
May 2001
Air Detector
Fresenius Medical Care
Ultrasonic Sensors
Prevent air entering patient body
Holder Size: 22 or 30 mm
Venous Pressure Connector
Venous Line Clamp (Optical Detector):
Closed in blood alarms
Keys for fluid level adjustment
May 2001
bibag Module
Fresenius Medical Care
May 2001
bibag Module
Fresenius Medical Care
May 2001
1.
2.
3.
4.
5.
May 2001
Monitor
Hydraulics
ECC
Dialyzer
Preparation
& handling
of fresh
dialysate
Handling of
used dialysate
and
ultrafiltrate
HD Machine
Ultrafiltrate
Blood
lines
Extracorporeal
Circuit
May 2001
High
High Safety
Safety Level
Level
-- 22 independent
independent microprocessor
microprocessor systems
systems
-- approved
approved hydraulic
hydraulic parts
parts
-- cyclic
cyclic pressure
pressure holding
holding tests
tests
Proven
Proven Volumetric
Volumetric Ultrafiltration
Ultrafiltration
Auto
Auto Self-test
Self-test
Auto
Auto Disinfection
Disinfection Programs
Programs
UF
UF // Na
Na Profiles
Profiles
Emergency
Emergency Battery
Battery Operation
Operation of
of Blood
Blood Systems
Systems (15
(15
20
20 min)
min) (Power
(Power Failure)
Failure)
Program
Program Heparinization
Heparinization Time
Time // Bolus
Bolus
May 2001
May 2001
BPM
SN-Double Pump
BTM
BVM
4008 HDF
CDS
Online HDF / HF
OCM
ONLINEplus
IrDA
bibag
May 2001
SCREEN
SCREEN11
Green
Greenindicates
indicatesthat
that
this
screen
can
be
this screen can be
viewed
viewedby
bypressing
pressing
confirm.
To
confirm. Tomove
move
the
cursor
press
the cursor pressthe
the
arrow
arrowacross
across
May 2001
Here
Hereisisdisplayed
displayedthe;
the;
Machine
type
Machine type
Software
Softwareversion
version
SCREEN
SCREEN22
T1
T1Test
Test
IfIfan
anerror
erroroccurs
occursaa
xx oror
number
numberappears
appears
totoinform
you
inform youofofthe
thefailure.
failure.
The
alarm
occurs
at
the
The alarm occurs at theEND
END
ofofthe
test
procedure
the test procedure
May 2001
The
Thevarious
varioussteps
stepsofofthe
the
T1
TEST
T1 TEST
green
greenhighlights
highlightsthe
thespecific
specific
part
of
the
test
sequence
part of the test sequence
SCREEN
SCREEN 33
IfIfthe
theT1
T1Test
Testisissuccessful
successful
the
screen
will
be
the screen will becompleted
completed
with
with
May 2001
Ultrafiltration
Menu
Dialysate
UF Values
UF Goal
UF Time Left
UF Rate
UF Profile
UF Volume
ISO Values
SO Goal
ISO Time
ISO Rate
ISO Volume
MAIN
MAINSCREEN
SCREENDISPLAY
DISPLAY
Treatment
mode
HDF
SN Click Clack
May 2001
Menu
Alarm limits
menu
Reinfusion
Needle Adjustment
prog
Arterial Limits
Venous Limits
TMP Limits
Mixing Ratio
Base Na+
Concentrate
Bicarbonate
Temperature
Flow
Na+ Profile
Start Na+
CDS
Conductivity window
System
parameters
Reset treatment
parameters
Brightness
Auto-On programme
(cleaning modes)
Date
System Time
(actual time)
Dialysis
representations
UF
UFMENU
MENU11
Entering
Enteringthe
theUF
UFData
Data
GREEN
GREENcursor
cursorshows
showsyou
you
which
data
can
be
entered
which data can be entered
WHITE
WHITEhighlight
highlighttells
tellsyou
you
which
figure
you
can
enter
which figure you can enter
To
Tomove
movethrough
througheach
eachfield
field
press
the
arrow
press the arrow
up
up
down
down
May 2001
Isolated
Isolatedsequential
sequential
ultrafiltration
ultrafiltrationcan
canalso
also
be
performed.
be performed.
To
Toenter
enterthis
thisfield
fieldpress
press
arrow
across
arrow across
Then
Thenfollow
followthe
thesame
same
process
as
for
entering
process as for entering
the
thedata
datafor
forUF.
UF.
Remember
to
Remember toenter
enterthe
the
Total
Goal
and
Time
Total Goal and Timeinin
the
theUF
UFvalues
valuesand
andthen
then
ONLY
the
values
for
ONLY the values for
the
theIsolated
Isolatedininthe
theISO
ISO
values
values
UF
UFMENU
MENU22
When
Whenusing
usingaaUF
UFprofile
profile
select
the
profile
required
select the profile required
11- -66and
andthe
theappropriate
appropriate
graph
will
be
displayed
graph will be displayed
Max
MaxRate
Ratewill
willthen
thenbe
be
displayed.
This
is
the
displayed. This is thestart
start
value
of
the
ultrafiltration
value of the ultrafiltration
CHECK
CHECKtotoensure
ensurethat
thatthe
the
UF
Co-eff
of
the
dialyser
UF Co-eff of the dialyser
isissuitable
suitable!!!!
May 2001
DIALYSATE
DIALYSATE MENU
MENU
Setting
Settingthe
theDialysate
Dialysate
concentration
concentration
Conductivity
Conductivitywindow
window
allows
us
to
move
allows us to move
ororcentre
centrethe
thealarm
alarm
guards
when
we
guards when we
change
changeany
anyofofthe
the
dialysate
parameters
dialysate parameters
May 2001
check
checkthe
themixing
mixingratio
ratio
concentration
of
the
concentration of thecanister
canister
concentration
required
concentration requiredfor
for
the
patient
the patient
bicarbonate
bicarbonatelevel
levelfor
forthe
the
patient
patient
dialysate
dialysatetemperature
temperature
dialysate
flow
dialysate flow
profile
profileififrequired
required++graphic
graphic
when
selected
a
start
value
when selected a start value
1mmol
1mmolgreater
greaterthan
thanthe
the
concentrate
level
will
concentrate level willbe
beshown
shown
This
can
then
be
increased
This can then be increased
according
according totothe
theDoctors
Doctors
prescription
prescription
TREATMENT
TREATMENTMODE
MODESCREEN
SCREEN
Single
SingleNeedle
NeedleClick-Clack
Click-Clack
can
canbe
beused
usedininemergencies
emergencies
e.g.
when
one
of
e.g. when one ofthe
theneedles
needlesblows
blows
and
it
is
difficult
to
insert
a
second
and it is difficult to insert a second
upper
upperlimit
limitshould
shouldbe
belowered
lowered
totothe
desired
value
by
pressing
the desired value by pressingthe
the
- -minus
key
minus key
lower
lowerlimit
limitshould
shouldbe
beraised
raisedtotoaa
value
value20
20mmHg
mmHghigher
higherthan
thanthe
the
pressure
already
achieved
using
pressure already achieved usingthe
the
++key
key
then
thenmove
movethe
thecursor
cursortotothe
theOFF
OFF
and
switch
ON
again
by
using
and switch ON again by usingthe
the
++/ /- -key
key
May 2001
IfIfdesired
desiredyou
youcan
canalways
alwaysreturn
returntototwo
two
needle
dialysis
at
a
later
time.
needle dialysis at a later time.
ALARM
ALARMLIMITS
LIMITSSCREEN
SCREEN
Here
Hereititisispossible
possibletoto
reposition
repositionand
andmake
makethe
the
alarm
guards
either
alarm guards either
wider
widerorornarrower
narrower
Arterial,
Arterial,
Venous
Venous
TMP
TMPLimits
Limits
Reinfusion
Reinfusion
allows
allowsusustotogive
givesaline
saline
during
or
at
the
end
during or at the endofof
the
thedialysis
dialysisby
by
OPENING
the
OPENING thealarm
alarm
guards
to
avoid
nuisance
guards to avoid nuisance
alarms
alarms
ItItisisactive
activefor
for3minutes
3minutes
ororititwill
automatically
will automatically
return
returntotonormal
normalstatus
statusifif
blood
bloodisisseen.
seen.
Needle
NeedleAdjustment
Adjustment
deactivates
deactivatesthe
thealarm
alarm
guards
for
arterial
guards for arterialand
and
venous
pressures
for
venous pressures for
33min.
min.totoallow
allowyou
youtoto
turn
turnorormanipulate
manipulatethe
the
needle
with
the
blood
needle with the blood
pump
pumprotating.
rotating.
May 2001
SYSTEM
SYSTEMPARAMETERS
PARAMETERSSCREEN
SCREEN
Auto
Auto-On
-Onprogramme
programme
allows
you
allows youtotoselect
selectaa
cleaning
cleaningprogramme
programmeand
andthe
the
time
you
would
like
the
time you would like the
programme
programmetotocommence
commence
ininthe
morning,
the morning,sosothat
thatthe
the
machine
will
be
cleaned
machine will be cleanedand
and
ready
for
use
before
the
staff
ready for use before the staff
arrive
arriveininthe
theunit
unit
The
Thenumber
numberindicated
indicated
here
can
be
entered
here can be enteredusing
using
key
board
to
quickly
key board to quicklyenter
enter
the
data
for
the
Auto-On
the data for the Auto-On
programme
programme
Brightness
Brightnessallows
allowsyou
youtoto
dim
dimororbrighten
brightenthe
thelights
lights
on
the
machine
on the machine
Reset
Resetmeans
meanstotoerase
eraseall
allthe
the
data
you
have
in
the
UF
menu
data you have in the UF menu
during
duringthe
thetreatment.
treatment.
ALL
DATA
ALL DATAwill
willthen
thenbe
belost
lost
System
SystemTime
Timeand
andDate
Dateshould
shouldbe
bechanged
changedtotoyour
yourlocal
localtime
time
This
leaves
the
factory
with
the
Time
in
Germany
!!
This leaves the factory with the Time in Germany !!
May 2001
4008
116
111
73
75
87
63
109 7
24b
112
24
61
86
30
97
41
76
29
92
54
31 32
43
33 34
2
66
114
150
6
9
68
89 88
151
26
c
115
77
35 36
37 38
85
78
21
65
84 115
74
125
94
98
95
10
12
a
90 b
91
22
23 94
May 2001
71
95 25
72
4008
111
73
87
116
7
109
112
24b
63
3
75
61
86
24
30
97
76
8
29
41
43
114
33 34
31 32
92
54
150
9
68
66
89
26
88
35 36
77
78
37 38
115
21
65
B
99
10
149
125
95
94
12
148
25
100
123
119
P
P
137
124
104
134
135
138
23
136
131a
133
132
120 118
22
130
102
117
121
122
91
90
b
May 2001
131b
90
a
85
84
151
95
94
72
71
74
115
1st cycle:
31
32
33
34
BC2
BC1
from Patient
Balance Chamber
35
36
37
Fresh Dialysate
May 2001
38
21
Dialyser
to Patient
2nd cycle:
Spend Dialysate to Drain
31
32
33
34
BC2
BC1
from Patient
Balance Chamber
35
36
37
Fresh Dialysate
May 2001
38
21
Dialyser
to Patient
Closed System
Fresenius Medical Care
0 ml
10 ml
10 ml
May 2001
Closed System
Fresenius Medical Care
Spend Dialysate
to Drain
Balance Chamber
to Patient
Dialyser
from Patient
Fresh Dialysate
to Balance Chamber
May 2001
Spend Dialysate
to Drain
Balance Chamber
Dialyser
to Patient
10 ml
from Patient
Fresh Dialysate
to Balance Chamber
UF Pump
10 ml
Ultrafiltrate to Drain
May 2001
Fill Program
Fresenius Medical Care
11st
st cycle:
May 2001
Fill Program
Fresenius Medical Care
22nd
nd cycle:
May 2001
Open System
Fresenius Medical Care
Pven
PDial
Dialysate Flow
Pump
TMP
electronic
TMP-Control
UFK = 4
ml
mmHg x h
Vacuum
Pump
TMP =
ml
mmHg x h
W
UFK x t
Dialysate
Preparation
System
May 2001
SD / TRAINING CENTER SCHWEINFURT
j:\sd\ch\folien\tpf_nma\ope_sy_e.cdr
x t [h]
Closed System
Fresenius Medical Care
Pven
PDial
1 6 0 0
TMP
timer
counter
UF-Pump
Drain
Dialysate
Flow
Flow- Pump
Fresh
1 ml
Old
UF Vol
fresh
Dialysate
from
Preparation
System
Advantage:
Very precise volumetric ultrafiltration control
Good for High-Flux Dialyzers
High effective & short time dialysis
May 2001
SD / TRAINING CENTER SCHWEINFURT
j:\sd\ch\folien\tpf_nma\clo_sy_e.cdr
End of Dialysis
Rinse
Rinse
PGM
RPGM 1:
1: --RPGM
R- endless
PGM 2:
2: --Rendless
Hot
Hot Rinsing
Rinsing
PGM
F-HR-CPGM 1:
1: --F-HR-CPGM
F-HR
PGM 2:
2: --F-HR
PGM
IHR
PGM 3:
3: --IHR
Dialysis
May 2001
Disinfection
Disinfection (Cleaning)
(Cleaning)
PGM
F-D-MPGM 1:
1: --F-D-MPGM
F-HDIS-MPGM 2:
2: --F-HDIS-MPGM
F-D-M-HRPGM 3:
3: --F-D-M-HRPGM
F-HDIS-M-HRPGM 4:
4: --F-HDIS-M-HRPGM
F-D(F)-MPGM 5:
5: --F-D(F)-M-
4008
116
111
73
75
87
63
109 7
24b
112
24
61
86
30
97
41
76
29
92
54
31 32
43
33 34
2
66
114
150
6
9
68
89 88
151
26
c
115
77
35 36
37 38
85
78
21
65
84 115
74
125
94
98
95
10
12
a
90 b
91
22
23 94
May 2001
71
95 25
72
In cleaning programs V91 opens with each BC cycle for 0.5 sec.
in order to clean the rinse chambers (90).
The Con. & Bic. Pumps are doing 1 stroke per BC cycle.
RINSE: (F, R, C)
Normal Cycles (18) : Flushing out
- V41 controlled by Float Switch
- BC cycled like in dialysate mode
- V24, V24b, V30, V87 open
- V26, V43, V84, V86 closed
May 2001
V86 open
V87 closed
V43 open
UF-Pump runs (max. frequency)
May 2001
May 2001
4008
116
111
73
75
87
63
109 7
24b
112
24
61
86
30
97
41
76
29
92
54
31 32
43
33 34
2
66
114
150
6
9
68
89 88
151
26
c
115
77
35 36
37 38
85
78
21
65
84 115
74
125
94
98
95
10
12
a
90 b
91
22
23 94
May 2001
71
95 25
72
May 2001
May 2001
With
With Diasafe
Diasafe (in
(in round
round brackets)
brackets)
&
& On-Line-HDF
On-Line-HDF (in
(in square
square brackets)
brackets)
Rinse
HR/HDIS 2 & 4
DIS 1 & 3
DIS 5
Flow [ml/min]
600
450
600
600
600
600
720
720
0.5
0.5
250
250
250
250
18x normal /
2x Fill + ASP on
13x normal /
2x Fill + ASP on
18x normal /
2x Fill + ASP on
18x normal /
2x Fill + ASP on
In Fill Cycle
Mandatory Rinse:
continuous
continuous
continuous
continuous
May 2001
Disinfection Dilution
Degassing Pump Speed Reduct.
Temp. [C]
Rinse
HR/HDIS 2 & 4
DIS 1 & 3
DIS 5
- /50
(66)
[82]
50
(66)
[82]
UF-Pump
UF-Pump
37
(49) [61]
Conc. Pump
32 strokes
(42) [52]
- / 1:25
by 6V
1:25
-
1:34
-
37
84
87
at NTC 3
37
37
33.5 / 41
78.5 / 90
Timer start 80
33.5 / 41
33.5 / 41
10 strokes
10 strokes
10 strokes
10 strokes
4008
116
111
73
75
87
63
109 7
24b
112
24
61
86
30
97
41
76
29
92
54
31 32
43
33 34
2
66
114
150
6
9
68
89 88
151
26
c
115
77
35 36
37 38
85
78
21
65
84 115
74
125
94
98
95
10
12
a
90 b
91
22
23 94
May 2001
71
95 25
72
May 2001
May 2001
2 conditions:
1.
2.
May 2001
May 2001
May 2001
May 2001
Blood Alarms
Fresenius Medical Care
TMP Alarm
Fresenius Medical Care
May 2001
May 2001
May 2001
Must
Must be
be OFF
OFF
May 2001
Must
Must be
be OFF
OFF
May 2001
Miscellaneous
Fresenius Medical Care
May 2001
4008
Filling
Filling Procedures
Procedures
BC
BC off
off
V91
V91 opens
opens
Pump
Pump 29
29
1300-1800ml/min
1300-1800ml/min
Pressure
Pressure (134)
(134)
>> +130mbar
+130mbar
V91
V91 closed
closed
BC
BC starts;
starts;
Pump
Pump 25
25 starts
starts
Pressure
Pressure (134)
(134)
<< +100mbar
+100mbar
V91
V91 opens
opens at
at
dead
-time of
dead-time
of BC
BC
24
30
97
76
43
54
150
9
68
66
89
26
88
121
122
35 36
78
37 38
115
21
65
125
95
12
148
124
22
130
137
134
135
138
23
136
131a
133
132
120 118
91
90
b
104
May 2001
85
84
77
102
P
P
151
biBag
biBag
131b
123
114
33 34
31 32
92
100
117
8
29
41
25
119
Medical Care
75
61
86
10
90
a
112Fresenius
24b
63
94
149
116
109
B
99
111
73
87
95
94
72
71
74
115
During
During the
the last
last 33 min
min of
of
the
the mandatory
mandatory rinse
rinse program
program
DIP
DIP switch
switch 77 of
of DIP
DIP array
array 22 of
of LP631
LP631
set
set to
to ON
ON
May 2001
4008
111
73
87
116
7
109
112
24b
63
3
75
61
86
24
30
97
76
8
29
41
43
114
33 34
31 32
92
54
150
9
68
66
89
26
88
35 36
77
78
37 38
115
21
65
B
99
10
149
125
95
94
12
148
25
100
123
119
P
P
137
124
104
134
135
138
23
136
131a
133
132
120 118
22
130
102
117
121
122
91
90
b
May 2001
131b
90
a
85
84
151
95
94
72
71
74
115
May 2001
Diagnostics - Applications
Fresenius Medical Care
Prerequistes:
Water Supply present
Test Box connected
1.
May 2001
Diagnostics - Applications
Fresenius Medical Care
2.
2.1
May 2001
Diagnostics - Applications
Fresenius Medical Care
May 2001
Diagnostics - Applications
Fresenius Medical Care
2.2
May 2001
Diagnostics - Applications
Fresenius Medical Care
May 2001
Diagnostics - Applications
Fresenius Medical Care
May 2001
Diagnostics - Applications
Fresenius Medical Care
3.
3.1
May 2001
Diagnostics - Applications
Fresenius Medical Care
Diagnostics - Applications
Fresenius Medical Care
- Test of V37:
- Open V33 ...
- Test of V31:
- Open V35 ...
- Test of V33:
- Open V37 ...
May 2001
Diagnostics - Applications
Fresenius Medical Care
3.2
May 2001
Diagnostics - Applications
Fresenius Medical Care
- Test of V36:
- Open V32
-
- Close V32
May 2001
Diagnostics - Applications
Fresenius Medical Care
- Test of V38:
- Open V34
- Test of V32:
- Open V36
- Test of V34:
- Open V38 ...
May 2001
May 2001
May 2001
May 2001
May 2001