Book8 Antineoplastic Drugs
Book8 Antineoplastic Drugs
Manuals
Table of Contents
Manuals
Table of Contents
Manuals
SELF-INSTRUCTIONAL
Book 8 - ANTINEOPLASTIC
DRUGS
Third Edition
Prepared
by
U.S. DEPARTMENT
NIH Publication
No. 94-2441
SERVICES
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Manuals
ACKNOWLEDGEMENTS
We are grateful to the following persons who have contributed to and critiqued this publication
and to the pharmaceutical companies that responded to our requests for information. Each has given
us unending encouragement
in the compilation of this list of antineoplastic
drugs. Without their
assistance, this publication would not have been possible.
Pharmaceuticals,
Adria Laboratories,
Bristol-Myers
Burroughs
Technology
Branch, National
Columbus, Ohio
Wellcome
Company, Research
Corporation,
Ciba Pharmaceutical
Laboratories,
Lederle Laboratories,
Laboratories,
Mead Johnson
Pharmaceutical
Miles Pharmaceutical
Roche Laboratories,
Schering Corporation,
Searle Laboratories,
La Jolla, California
Irvine, California
Lilly Research
Indianapolis,
Indiana
New Jersey
Chicago, Illinois
Cancer Institute
Calbiochem-Behring
Herbert
and Authorization
Philadelphia,
iii
Pennsylvania
Section,
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Manuals
BOOK $: ANTINEOPLASTIC
DRUGS
Table of Contents
Manuals
CONTENTS
Page
INTRODUCTION
A.
B.
Chemotherapeutic
Drugs ................................................
Combination Regimens
C.
15
.................................................
29
..................................
35
39
49
Agents ...........................................
.......................
51
.......................
51
..........................
55
G.
61
...
........................
69
73
Section 6. Drugs Used in the Treatment of AIDS and Its Complications (Introduction)
85
91
.......................
. ...............
95
H.
103
I.
105
J.
Index ..............................................................
109
vii
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Introduction
OBJECTIVES AND CONTENT
OF INSTRUCTIONAL
BOOK 8
Book 8 was first published in 1981 in response to numerous requests from SEER Program
participants for identification of drugs which should be included on the abstract of the medical record
as cancer-directed
therapy. The demand for this manual has been rewarding, and, therefore, this
update is being offered in 1993.
Many new anti-cancer agents have been developed since the original publication of this book, and
these have been added to the appropriate sections of the new edition. Experimental
drugs proven
to be ineffective are listed with a '#' sign following the drug name. Brand names formerly used and
drugs not in clinical use at this time are also designated with a '#' sign. The index will assist you in
locating a particular drug.
This publication
1.
2.
3.
4.
5.
6.
Chemotherapeutic
drugs and combination regimens
Ancillary drugs
Differentiation-inducing
agents
Biological response modifiers
Hormones and agents acting via hormonal mechanisms
Drugs used in the treatment of AIDS and its complications
Chemical formulae and information about drug metabolism and mechanisms of action are not
included in this manual. If you find it necessary to know the drug's formula or pharmacology, please
refer to the following resources:
1. Fleeger CA, ed. USAN and the USP Dictionary of Drug Names.
States Pharmacopeial Convention, Inc., 1992.
Rockville,
MD, United
Montvale,
JB Lippincott
No. 91-2141.
Economics
Bethesda,
Data, 1993.
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In October 1982, the National Cancer Institute (NCI) announced the establishment of PDQ
(Physicians Data Query). PDQ is a clinically oriented computer database developed to make recent
cancer information widely available to the medical community. PDQ provides state-of-the-art cancer
treatment information and descriptions of NCI-sponsored clinical trials for all major cancer sites. For
clinical trials involving antineoplastic agents, protocol summaries can be retrieved using a drug's
generic name, acronym, short name, or synonym.
Information on both established drugs and investigational agents can be obtained through PDQ
from CANCERLIT
searches on the National Library of Medicine (NLM) computer system.
CANCERLIT is a bibliographic database that contains approximately 700,000 citations, including
journal articles, meeting papers, books, reports, and doctoral theses. It is updated each month with
close to 5,500 new citations, most containing abstracts.
Information about access to PDQ can be obtained from the PDQ Information Coordinator,
National Cancer Institute, R. A. Bloch International Cancer Information Center, Building 82, Room
105, 9030 Old Georgetown Road, Bethesda, MD 20892. Instructions for accessing CANCERLIT
through PDQ are included in the PDQ User's Guide.
Continuous updating is required to make this manual a useful reference. Therefore, suggestions
with respect to changes or additions are welcome. With your help, this book can be an up-to-date
directory of antineoplastic agents that you may encounter in abstracting a medical record.
Cancer Statistics Branch
Surveillance Program
Division of Cancer Prevention and Control
National Cancer Institute
Executive Plaza North, Room 343J
Bethesda, MD 20892
Telephone:
(301) 496-8510
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Underlined
Names
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Section 1
CHEMOTHERAPEUTIC
REGIMENS
Agents
Scientists work continuously to develop new antineoplastic agents and to explore different methods
for using agents which are currently available. New drugs undergo rigorous preclinical evaluations
to determine antineoplastic effects in cancer cell cultures and animal tumor models. Drugs which
demonstrate potential in preclinical studies then must be formulated for human use and go through
toxicology testing in laboratory animals before entering systematic clinical evaluation.
Clinical studies of chemotherapeutic
agents are conducted according to strict guidelines, or
protocols, which provide specific instructions
for patient selection, drug administration,
and
observation of treatment effects. There are three phases to clinical evaluation:
Phase I clinical trials assess the pharmacology and dose-limiting toxicity of the drug in humans.
Patients in Phase I clinical trials generally have advanced malignancies which are no longer
amenable to conventional cancer therapy.
Phase II studies determine the activity, or therapeutic effect, of a new drug in specific tumor
types.
Patients in Phase II clinical trials have tumors that are no longer amenable to
conventional therapy; their tumor masses must be measurable on clinical examination or by
radiographic studies to evaluate tumor response to the new drug. Response rates, duration of
response, and frequency and severity of side effects are recorded in Phase II clinical trials.
Phase III clinical trials compare the efficacy of a standard drug (or treatment) to that of a new
drug (or treatment) which is expected to be at least as effective as the standard therapy for a
specific cancer stage and primary site. In most Phase III studies, patients are randomly assigned
to treatment groups, and the response rate and toxicity for the new therapy is compared to that
for the standard therapy ("control"). Phase III studies establish the place of a new drug or
treatment in clinical oncology practice.
Clinical studies, especially Phase III clinical trials, require large numbers of patients with specific
tumor types and stages. To complete these studies in a timely and efficient manner, investigators
from different practice locations have joined together as cooperative clinical trials groups. Through
this mechanism, patients from diverse geographical areas can enter a clinical study under the care of
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their own oncology specialist. Each patient receives therapy according to a defined protocol, and data
on response and toxicity for each patient are collected by a central office for monitoring and analysis.
Many cooperative groups evaluate surgical procedures or radiation therapy treatments, often
combined with chemotherapy.
Some cooperative groups conduct Phase I-II studies as well as Phase
III randomized controlled clinical trials.
Examples of cooperative clinical trials groups include the
Cancer and Leukemia Group B (CALGB), the Southwest Ontology Group (SWOG), the Eastern
Cooperative Oncology Group (ECOG), the National Surgical Adjuvant Breast and Bowel Project
(NSABP), and the Radiation Therapy Oncology Group (RTOG).
See page 95 for a list of the
cooperative clinical trials groups.
derivatives:
3. Alkyl sulfonates:
triethylene-thiophosphoramide
busulfan (Myleran)
(Thio-TEPA)
phenylalanine
mustard
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4. Nitrosoureas:
5. Triazines:
carmustine
(Lomustine)
DTIC (Dacarbazine)
Antimetabolites are structurally similar to natural metabolites which are necessary for cell function.
These agents replace natural metabolites in important molecules, altering the function of enzymes
required for cell metabolism and protein synthesis. This interference is most pronounced during the
S (synthesis) phase of cell division when DNA, RNA, and protein synthesis occurs. The enzymatic
block produced by methotrexate can be bypassed by administration of folinic acid (leucovorin), which
then "rescues" normal cells from methotrexate
action. Antimetabolites
include:
1. Folic acid analogues:
2. Pyrimidine
methotrexate
analogues:
3. Purine analogues:
5-fluorouracil
6-mercaptopurine
(Amethopterin,
MTX)
(5-FU)
(6-MP)
Natural products include antibiotics, plant alkaloids, and enzymes. Antitumor antibiotics may
have antimicrobial properties, but their cytotoxic properties are most prominent.
These agents
prevent nucleic acid synthesis by a process called intercalation and block DNA and RNA
transcription.
They act throughout the cell cycle, but some are more effective during S (synthesis)
and M (mitosis) phases. Antitumor antibiotics include dactinomycin (Actinomycin D), doxorubicin
(Adriamycin), daunorubicin (Daunomycin), bleomycin (Blenoxane), and mitomycin C (Mutamycin).
Plant alkaloids, derived from the periwinkle plant l/inca rosea, are also called vinca alkaloids.
These drugs interfere with the microtubular spindle proteins necessary for cell division and thus
inhibit mitosis (M phase). Vinblastine (Velban, VBL) and vincristine (Oncovin, VCR) are the two
vinca alkaloids commonly used in clinical oneology.
L-asparaginase (Elspar) is an enzyme which catalyzes the breakdown of asparagine into aspartic
acid and ammonia. It inhibits the growth of tumor cells that are unable to synthesize l-asparagine,
an amino acid necessary for protein synthesis. Cells that make l-asparagine from aspartic acid are not
affected.
Several anticancer drugs are classified as miscellaneous agents, either because they do not fall into
one of the distinct categories above or because their action is not fully understood.
Cis-diammine
dichloroplatinum
II (Cisplatin) is a platinum-containing
complex which binds to DNA and disrupts
its function. Hydroxyurea (Hydrea) inhibits enzymes which are important in repair of DNA damage.
Procarbazine (Matulane) is broken down by the body into active metabolites which bind nuclear DNA
and inhibit DNA, RNA, and protein synthesis.
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Dose *
Schedule
M - Nitrogen mustard
6.0 mg/m 2 IV
Days 1 and 8
O - Vincristine
1.4 mg/m 2 IV
Days 1 and 8
P - Procarbazine
P - Prednisone
(Oncovin)
100.0 mg/m 2 PO
Days 1 through 14
40.0 mg/m 2 PO
Days 1 through 14
* Dose is usually calculated as milligrams (mg) drug per square meter (m 2) body surface
area. Body surface area is determined from charts depicting surface area as a function of
the patient's height and weight.
When disease is widespread, as in the acute leukemias, intensive chemotherapy
may be
administered in an attempt to eradicate all evidence of disease. This period of treatment is called
induction; the absence of clinically demonstrable disease is termed remission. Following induction,
a second period of intensive treatment (consolidation) may be given to increase the remission rate
or increase duration of remission. In some clinical situations, a prolonged period of less intense
chemotherapy, called maintenance therapy, is also administered to delay disease recurrence (relapse).
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Administration
of Chemotherapy
The most common routes of administration of chemotherapy are oral and intravenous. The drug
enters the bloodstream
by absorption from the gastrointestinal
tract or directly by intravenous
injection and is carried to cells throughout the body. However, in specific clinical situations, other
methods of administration are required to achieve higher drug concentrations
in specific tissues or
to access tissues that are isolated by physiologic barriers.
Drugs that do not cross the blood-brain
barrier must be administered
directly into the
cerebrospinal fluid (CSF) surrounding the brain and spinal cord (intrathecal administration).
This
is accomplished through a lumbar puncture (spinal tap) needle, into an implanted access device
(Ommaya reservoir). Intrathecal chemotherapy is used to treat meningeal leukemia or lymphoma or
occasionally in other tumors which have meningeal metastases. In patients with acute iymphoblastic
leukemia, intrathecal chemotherapy may be given as prophylaxis to prevent the development of
meningeal leukemia. Methotrexate and cytosine arabinoside are chemotherapeutic
agents commonly
used intrathecally.
Chemotherapeutic
agents such as bleomycin may be injected directly into the pleural or pericardial
space to control malignant effusions.
Intraperitoneal
spread by direct
peritoneal cavity
concentrations
of
administration.
administration of drugs may be used to treat tumors such as ovarian cancer which
extension through the abdominal cavity.
Chemotherapy
is injected into the
using techniques similar to peritoneal dialysis. This approach allows increased
drug in the abdominal cavity compared to lower levels achieved by intravenous
Specialized infusion methods have been designed to increase drug delivery to affected tissues while
sparing normal or uninvolved tissues. These require insertion of a catheter into the artery which
supplies blood to the affected area and infusion of the drug through the catheter.
Hepatic artery
infusion has been used to treat primary liver tumors or liver metastases, and carotid artery infusion
has been attempted to treat head and neck cancers or brain tumors. While advances in technology
have simplified these infusion procedures, they are still investigational.
Their role needs to be
determined by careful scientific evaluation through clinical trials.
Monitoring
Side Effects
Antineoplastic
drugs affect not only cancer cells but also normal cells. For chemotherapeutic
drugs, the type and severity of side effects depend on the specific agent, its dose, and its route of
administration.
Side effects are usually temporary and respond to supportive treatment.
However,
if toxicity is severe or persistent, drug dosages may be reduced for subsequent cycles to decrease
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toxicity, a new drug with similar actions but different side effects may be substituted for the drug
causing symptoms, or scheduled therapy may be delayed to allow recovery. Most protocols include
specific directions for dose modification due to toxicity.
In patients with chronic
chemotherapeutic
agents may
the drugs and their metabolites
Drug doses may be decreased
have these medical conditions.
The bone marrow is the site of production of circulating blood cells: red blood cells (RBCs),
which contain hemoglobin and transport oxygen to the tissues; white blood cells (WBCs), which fight
infection and function in immunity; and platelets, which prevent bleeding when small blood vessels
are injured. Bone marrow cells divide rapidly and are very sensitive to most antineoplastic agents,
so that hematologic side effects are common in patients receiving these drugs. Toxicity may be
expressed as decreases in one or more of the circulating blood cell types.
Most patients receiving chemotherapy develop a decrease in RBCs (anemia), reflected by a
fall in laboratory measurements of hemoglobin or hematocrit.
Anemia may be associated with
generalized symptoms of fatigue and weakness, or it may exacerbate cardiovascular symptoms of
shortness of breath (dyspnea) or congestive heart failure. Blood (RBC) transfusions are given if
anemia becomes severe or symptomatic.
A decrease in platelet count (thrombocytopenia)
may result in the appearance of small redpurple hemorraghic spots (petechiae), particularly on the skin of the lower legs and on the oral
mucosa, large bruises (ecehymoses), or blood in the urine (hematuria).
More serious internal
hemorrhages may develop without apparent cause in patients with very low platelet counts.
Platelet transfusions are usually given to patients with severe thrombocytopenia
to prevent
significant bleeding.
A decrease in the number of white cells (leukopenia), particularly in neutrophils which fight
bacteria (neutropenia),
makes the patient more susceptible to bacterial and fungal infections.
WBC transfusions may be used in patients with life-threatening infections which are unresponsive
to antibiotics.
The term pancytopenia is used when all blood cell lines are decreased.
Hematologic toxicity associated with chemotherapy for most cancers usually lasts seven to ten days
at the most. However, induction therapy for acute leukemias, intensive chemotherapy for other
widespread malignancies, and bone marrow transplantation
often result in prolonged periods of
pancytopenia.
Patients undergoing these treatments require intravenous antibiotics and frequent
transfusions of RBCs and platelets for hematologic support until bone marrow recovery occurs.
Gastrointestinal
symptoms due to antineoplastic drugs may include nausea, vomiting, diarrhea,
mouth ulcers (stomatitis), and irritation of the esophagus (esophagitis) or stomach lining (gastritis).
Non-chemotherapeutic
medications can be very effective in controlling
these side effects.
Gastrointestinal
toxicity is usually short-lived (one to two days), but, in some situations, may be
prolonged (five to six days).
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Rapidly-dividing cells at the base of the hair follicles are also sensitive to chemotherapy.
Thinning
or loss of body hair (aloi_eia) occurs in many patients receiving chemotherapy.
This is usually most
pronounced on the scalp, but beard, axillary, pubic, and leg hair may also be affected. Hair growth
resumes when chemotherapy is discontinued.
In both men and women, cells responsible for reproductive
function may be affected by
chemotherapy.
In premenopausal women, menstrual cycles may become irregular or stop completely,
and hot flashes may occur.
Men may experience a decrease in the number of spermatozoa
(oligospermia).
Patients who complete chemotherapy may produce normal children; however, fertility
may be reduced in long-term cancer survivors who have received chemotherapy.
Inflammation of the urinary bladder with bleeding into the urine (hemorrhagic cystitis) may occur
with chemotherapeutic
agents which are concentrated
in the urine.
Cyclophosphamide
and
ifosphamide are examples of drugs which may cause hemorrhagic cystitis. This complication may be
prevented by increased fluid intake and/or by ancillary drugs which protect the bladder epithelium.
Renal toxicity, manifested by increases in serum creatinine and blood urea nitrogen (BUN) and
electrolyte imbalance, may be associated with cisplatin therapy.
Cardiovascular side effects are limited to specific agents. Antitumor antibiotics with anthracycline
chemical structures,
doxorubicin (Adriamycin)
and daunomycin
(Daunorubicin),
can damage
myocardial cells. Because congestive heart failure occurs more frequently in patients who receive
high total doses of drug, a total dose limit is required in regimens containing these agents.
Pulmonary toxicity has been described in patients who receive long-term therapy with alkylating
agents (busulfan,
cyclophosphamide,
and BCNU) and antitumor
antibiotics
(bleomycin and
mitomycin).
The development of pulmonary fibrosis may present as shortness of breath and has
clinical findings of diffuse changes on chest x-ray and decreased oxygen diffusion on pulmonary
function studies.
Fatigue and/or muscle weakness may result from anemia or from direct effects of the drugs on
muscles or nerves. Patients receiving corticosteriods such as prednisone for prolonged periods may
develop muscle weakness (myopathy), particularly involving the muscles of the upper arms and legs.
Certain chemotherapeutic
agents, such as the vinca alkaloids, cisplatin, and taxol, are associated with
damage to the peripheral nervous system. The loss of sensation in the hands and feet (peripheral
neuropathy) which develops in many patients receiving these drugs often improves with time when
the agent has been discontinued.
Dermatitis associated with chemotherapy
is uncommon.
Patients receiving 5-fluorouracil by
continuous infusion may develop redness and peeling of the skin on palms and soles (Hand/Foot
Syndrome).
Exfoliative dermatitis may be a dose-limiting toxicity of the drug PALA.
As more cancer patients achieve cure or prolonged survival, attention has focused on late sequelae
of chemotherapy
and problems of cancer survivors.
Second primary malignancies related to
treatment, such as acute non-lymphocytic leukemia in patients treated with alkylating agents, may
occur years after completion of therapy. Current treatment plans attempt to decrease the potential
for late complications whenever possible.
For example, alternating cycles of MOPP and ABVD
chemotherapy
in patients with Hodgkin's disease reduces the total dose of alkylating agents and may
decrease the risk of late sequelae.
11
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12
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In certain situations, chemotherapy has been used to reduce the bulk of a locally advanced primary
cancer prior to surgical resection or radiotherapy. This approach is called neoadjuvant (or primary)
chemotherapy.
The role of neoadjuvant chemotherapy in management of head and neck carcinomas,
lung cancer, esophageal
malignancies, and locally advanced breast cancer is currently under
investigation.
Progress in Cancer Treatment with Chemotherapy
Although chemotherapy is a relatively new modality in cancer treatment, antineoplastic agents are
used at some time during treatment in most patients with cancer. The development
of effective
combination chemotherapy regimens has made cure possible in many patients with advanced disease
and has delayed tumor recurrence and prolonged survival in many patients with early stage cancer.
The following table summarizes advances in cure of advanced
adult and pediatric malignancies.
Curability of Disseminated
Cancer
with Chemotherapy
Disease
Therapy
Cure Rate
CTX
>
Hodgkin's
and IV)
disease
CTX
> 50%
Testicular
carcinoma
Cq'X + SURG
> 75%
Adults
Gestational
Ovarian
(Stages
III
(Stage
lII)
choriocarcinoma
Methotrexate
actinomycin
carcinoma
Acute myelocytic
+
D
50%
90%
Alkylating agents
or CTX
10 - 20%
CTX
20%
leukemia
Children
Acute lymphocytic leukemia
Non-Hodgkin's
lymphoma
Burkitt's
CTX
lymphoma
Wilms's tumor
Childhood sarcomas
CTX=Combination
chemotherapy;
SURG=Surgery;
Cancer
+ cranial
XRT
> 50%
Cyciophosphamide
or CTX
_ 50%
SURG,
> 50%
XRT_-Radiation
Chemotherapy:
13
CTX, XRT
therapy
Principles and Practice.
JB
in both
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CHEMOTHERAPEUTICDRUGS
synon_sand
Generic
Name
Short
Maims
Acfvicin
Brand or Trade
Haines
+.MSC#o.
163501
Aclarubicin
ACM, ACR,
ACN-A
Aclacin_cin,
Actacin_cin-A#,
Ac[acinon, Ac[arubein, Antibiotic NA,
144 A1 (anthracycline)
208734
Acodazole (HCf)
AD-32
EU-3120
305884
Acronine*
Acr_yci_,
Acronycine,
Compound 42339
403169
Adozelesin
U-_,975
Aianosine
L-Alanosine
Atpha-TGdR
Deoxythioguanosine
hydrate,
Thioguanosine
deoxyriboside
071851
013875
Antitumor antibiotic
053397
Attretamine*
HMM
A_cin
(antitumor
antibiotic)
153353
Ametantrone Acetate
C]-_1
287513
Aminopterin
APGA
000739
Aminothiadiazole
ATDA, A-TD
TF-128,
2-Amino-l,3,4-thiadiazole
004728
Amsacrine
AMSA,
m-AMSA
Acridinyt
anisidide,
CI-_O
(miscellaneous
Anguidine
ANG, OAS
ANG 6b,
Anguidin,
Amsidyt,
agent)
Diacetoxyscirpeno[
Aniline mustard
L_ochin,
TL 476
L_ocin,
AnthraRcin
Antra_cfn,
2-Propenamide
Anthrapyrazole
L_(_Cluin,
249992
141537
018429
C 1941
Aphidicolin Gtycinate
A_idicolin-17
Asaley
Asalex
167780
Aspen[in#
U-13,933
093158
000749
067239
5-Aza-2'Deoycytidine
DAC
8-Azaguanine
Azan
8-AG,
AZG
gIycinate,
ICI 137233
303812
Azapicyl
Azaribine*
AZR
]5
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CHENOTHERAPEUT
]C DRUGS
Generic
Name
Azaserine*#
Short
Names
AZAS, AZS
Azathioprine*
_rATP, AzAT
Azetepa#
Azidothymidine
AZT
s_o_
__
+ISC No.
Azaserin,
CI 337, CN 15,757,
Diazoacetylserine,
L-Serine diazoacetate
ester,
P-165 (antimetabolite)
000742
Azanin,
Azathioprin,
Azatioprin,
Azothioprine,
BW 57-322,
Xmuran,
Imurek,
Imuret, Muran
039084
Azatepa,
064826
CL-25477,
Thiatriamide
3'-Azido-3'
Deoxythymidine,
BW A 509U,
Retrovir,
Zidovudine
(used in treatment
Kaposi's
sarcoma only)
Azotomycin
AZOT
Duazomycin-B,
6-Azuridine
AzUR
6-Azauracit
riboside,
Azauridine,
6-Azur,
6-Azauridine,
Ribo-azauracil,
Ribo-azuracil,
Riboazuracit
032074
Baker's
BAF, TZT
Baker,s antifolante,
Ethanesulfonicacid compound, Triazinate
139105
AB-103, Benzcarbimine,
ENT-50451
037096
antifol
Benzodepa
Beta-TGdR
Antibiotic
1719
602670
of
Duatar#,
056654
BTGR, TGdR
Thioguanine deoxyriboside,
B-21Deoxythioguanosine
071261
Bisantrene
(HCl)
ADAH, ADC
B_santrene,
CL-216,942,
OrangeCrush# (anthracene
derivative)
337766
Bteomycin
Sulfate
BLEO, BLE,
BLM
Blenoxane,
(antitumor
125066
Bleomycin,
antibiotic)
NDC 0015-3010
BMY-45622
Brequinar Sodium
Dup 785
368390
Bromacrylide#
2-Propenamide
066248
Bropirimine
U-54,461
Bruceantin
BRU
165563
339555
Bryostatin
Busutfan*
000750
BWA 77-3U
Crisnatot
Cactinomycin
Actinochrysin,
Actinomycin
C#,
H.B.F. 386, Sanamicia,
Sanamycin,
Sandamycin, (antitumor
antibiotic)
018268
Camptothecine
100880
Camptothecin
CAMP
Caracemide
sodium
253272
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CXENOTHEPJ_T I C DRUGS
svnonv_ and
Generic
iamme
Short
Names
Carbetimer
Brand or Trade
liames
+ISC Mo.
N-137
Carboplatin*
CBDCA
JM-8,
ParapLatin.
241240
Carmustine*
BCNU
BiCNU, Carmustinea,
(a[kytating
agent)
Carubicin (HCL)
CMM
(nitrosourea)
CB-10-277
409962
275649
180024
208107
2-CdA
2-Chtoro-2'Deoxyadenosine,
Leustatin
Cladribine,
105014
Chtorambucit*
CHL, CLB
Ambochtorin,
CB-1348, Chloraminophene,
Chlorbutin,
Chlorbutine,
EcloriL,
Leukeran,
Leukersan,
Leukoran,
Linfitizin,
Linfolysin
(atkylating
agent)
003088
Chlorozotocin
CLZ,
SRI 5244
(analog
of Streptozocin)
178248
Chlorsutfaquinoxatine
COS
Chtoroquinoxatine
339004
Chromomycin
CZT, DCNU
A3#
Aburamycin
Toyamicin.
sulfonamide
B, Antibiotic
Toyomycin
B 599,
CI-921
058514
343499
CI-937
Citastatin
Sodium
Component
Cirolemycin*
Cisplatin*
of Primaxin
(antibiotic)
U-12,241
077950
Cis-Diamminedichtoroptatinum
(lI),
Cis-Platin, Cisplatino (Spanish),
Cis-Platinum
it#, Cisptatyt,
Neoptatin,
Peyrone's
chloride,
Ptatinex,
Ptatinot,
PLatinum (miscellaneous
agent)
119875
Ctomesone
338947
Colcemid
Atkatoid
H-3, C-12669,
Colcemide,
Cotchamin, Cotchicine,
Deacetyt-N-methytcotchicine,
Demecolcine0
Desacetytmethytcotchicine,
Desmecotcine,
Kotchamin,
Kolkamin,
Omain, Omaine,
Santavy's
Substance F, Substance F
(Reichstein's)
003096
CPT-11
Crisnatot
mesytate
Cyctocytidine
(HCI)
BM A770U mesylate
CYC,
Cycto-C
Ancitabine
hydrochtoride,
Ancytabine,
CycLoCMP hydrochtoride
(miscellaneous
agent)
17
145668
Table of Contents
Manuals
CHENOTHERAPEUTI
C DRUGS
s_om_ ____
Generic
Hame
Short
Names
Brarl., or
Trade Names
+IISC No.
Cyctodisone
348948
Cyctohexanecarboxmide
Aziridinyt
cyctohexane,
Cyctopentenytcytosine
Ce-Cyd,
Cyclophosphamide*
026271
Cytarabine*
053878
CTB
104801
See Chtorsu[faquinoxatine
339004
Dimethyl-triazeno-imidazote-carboxamide, DTIC-Oome,
(antimetabo[ite)
045388
Cytembena
CB 1639,
051915
Cyctoteucin
(HC[)
Cycloteucine,
Ba 246/+8
WR 14997
001026
CPE-C
CQS
Dacarbazine*
DIC,
ICT
Dactinon_cin*
003053
Daun, Dauno,
DNM, ONR, ORB
Acety[adriamycin,
Cerubidine,
Daunobtastin,
Daunomycin, Oaunomycin-HCL,
Daunorubicin,
Daunorubicine,
Leukaemomycin C, NDC-0082-4155,
RP-13057,
Rubidomycin-HC[,
Rubomycin C
(antitumor
antibiotic)
082151
3-Deazauridine
DAU
Deazauridine,
126849
Decitabine
DAC
Deoxydoxorubicin
HCI
DxDx,
4-DxDx
Daunorubicin
(HC[)*
Deoxysperguatin
Oetorubicin
Oexormaplatin
HC[
DTIC,
ICDT,
375575
E0-26
127716
4'-Deoxyadriamycin
4'-Deoxydoxorubicin,
]-Dox, lMl 58
hydroch[oride,
Esorubicin
15-DeoxysperguaLin
Heptanamide
trihydrochtoride,
DTR
U-78,938
]8
267469
HCl,
356894
Table of Contents
Manuals
CHENOTHERAPEUT
| C DRUGS
Sy,_xWms
ond
Generic
Name
Brand or
Trade Names
+MSC No.
Dexrazoxane
ADR-529,
[CRF-187
169780
Dezaquanine
CI-908
Deza_uanine
Short
Names
NesyLate
DFNO
CI-908
DFMO (HOt)
DHAC
261726
mesyLate,
PD 90,695-73
337250
hydrochtoride,
264880
Dianhydrodulcito[
DAG
Dianhydrogatactitol,
Dutcitotdiepoxide,
Gatactitol
(miscettaneous
agent)
132313
Diaziquone
AZO
Aziridinyt
(quinone
Benzoquinone,
derivative)
Cl 904
182986
Dibromodutcito[
DBD
Dibromdutcit,
Etobromot,
Mitotactot
(miscellaneous
Mitotac,
agent)
104800
Dibromomannito[
DBM
Dibromannit,
Hietobromot,
Mitobronitol,
Myebrot,
Myelobromot
(atkytating agent)
094100
Dichloroallyl
[awsone
DCL
Dichtorota_chot
126771
Dichtoromethotrexate
DCH, DCMTX
DichLoroamethopterin,
trexate
Didemnin
DichLoroNetho-
325319
Digtycoatdehyde
INOX, STGDR
]nosine
diatdehyde,
Wy-5321
Dihydrolenperone
Dihydro-lenperone
DON
6-Oiazo-5-Oxo-L-Morteucine
Doxorubicin
029630
(HC!_*
Doxorubicin-DNA
118994
343513
(9C!)
007365
Adriamycin,
Adriamycin-TM,
Adribtastina
(Italy),
FT-106, 14-hydroxydaunomycin, Rubex (antitumor
antibiotic)
123127
(N-Acetyt
DON)
051097
526417
comptex
Duazomycin
DuborimycJn
Echino_ycin
Ouinomycin
626715
Edam-lO
Edatrexate
CG 30694
Eflornithine HCf
E[samitrucin
BBM-2478A, BMY-28090
Emetine
EMET
Emetin,
Emetine
19
monohydrochloride
033669
Table of Contents
Manuals
_THERAPEIIT
I C DRUGS
sy,_nylsand
Generic
Name
Emofotin
(sodium)
Short
Names
MeTHHF
Brand or
59156
Epipropidine#
Eponate,
(HCf)
+NSC No.
Enpromate#
Epirubicin
Trade Names
EPI
IMI-28,
139490
112682
Epoxypropidine,
LY 28002
Pharmorubicin
056308
259642
Ethidiumchloride
Babidiumchloride,
Novidium chloride
Homidiumchloride,
084423
Ethogtucid
Epodyl,
lCI-32865
080439
9-Ethyl-6-Mercaptopurine
9-Ethyl-6-MP,
Etoposide*
EPEG, VP-16,
VP-16-213
Etogtucid0
79T61
014575
Epipodophyllotoxin
ethytidene
9tucopyranoside,
Ethylidine-Lignan-P,
Podophy[totoxin
derivative,
Vepesid
(plant alkaloid)
141540
Etoprine
Fadrazole HCf
Fazarabine
CGS-16949A
Ara-AC
Fenretinide
281272
McN-R-1967
F[avone acetic
acid
FAA, FVA
F3TDR
Flavone-8-Acetic Acid
347512
Trif[uorothymidine,
075520
Trif[uridine
Floxuridine*
FUDR, 5-FUDR,
5-FURD
027640
Fludarabine
Phosphate
2-FAMP
Fludara,
2-Fluoroadenine
arabinoside5-Phosphate,
2-F[uoro-ARA
AMP
312887
2-Fluoroadenosine#
2 FAS
SRI-727
030605
Fluorodopane
Fluorodopan,
Ftuorouraci[*
5-FU,
FU
Fluorpan
Adrucit,
Efudex, Fluoroptex,
5-Fluorouracil,
Fluracil,
5-Fturacil,
Fturit,
Oraci[,
Ro 2-9757
(fluorinated
pyrimidine)
(antimetaboLite)
Flurocitabine#
AAFC, Ro 21-0702
Fosquidone
GR 63178K
Fostriecin
Sodium
0?3754
Antibiotic
Pyranone
CI-920,
Phosphate
Antibiotic
CL 1565A,
019893
339638
Fotemustine
Ftorafur
See Tegafur
2O
148958
Table of Contents
Manuals
CHENOTHERAPBJT
]C DRUGS
Generic
Name
Short
Names
Gemcitabine
synonymand
Brand or Trade
Names
+MSC lio.
LY188011
Gemcitabine
HCL
LY188011
hydrochtoride
GR 63178A
Guanazote
3,5-Diamino-s-triazote
Hepsutfam
1,7-Heptanediytsutfamate
Hexamethytmetamine
HMM, HXM
Homoharringtonine
HH
Hycanthone
See Attretamine
013875
Etrenol,
Hycanthone methanesutfonate,
Hycanthone monomethanesulfonate
HCt*
[fosfamide*
4-DMDR,
IFX,
IDA
IPP
032065
See Dexrazoxane
169780
4-Demethoxydaunorubicin,
BM 41,440
Imipenem
Imipemide#,
Indicine-N-oxide
INDI,
ldamycin,
component of
Primaxin
256439
109724
(antibiotic)
INO
132319
Inproquone
E-39,
Iprop[atin
lnprochone,
RP-0870
017261
PLatinum-
JB-11
256927
249008
Liposome-Doxorubicin
Lovastatin
IMI-30
Itmofosine
Lomustine*
142982
107392
]CRF-187
Lometrexo[
329680
5-HP
thiosemicerbazone
Hydroxyurea*
Idarubicin
(ester)
141633
(mesylate)
5-Hydroxypico[ina[dehyde
001895
Kit
Sodium
(TLC-Dox 99)
620212
LY 264618 disodium
CCNU
Betustine
(nitrosourea),
CeeNU,
Chtoroethytcyctohexytnitrosourea,
ICIG 1109 (atkytating
agent)
Mevacor, Mevinolin#
21
079037
Table of Contents
Manuals
CHENOTHFRAPEUT
I C DRUGS
Generic
Name
Short
Names
+NSC No.
Mafosfamide
Mafosfamide
L-tysine
626122
Magnamycin
051001
Mannosutfan
R-52,
201289
M-Azido-Pyrimethamine
Ethane Sulphonate
Zitostop
Marcettomycin
265211
Masoprocot
Actinex,
CHX 100,
meso-NDGA
Maytansine
MTS
Ansamacrotide
product)
Mechtorethamine
(HCL)*
Chtoromethine-HCt,
Dichtoromethytdiethytamine-HCl,
Mechtorethamine,
Mustargen, Mustargen-HCt,
Mustine,
NH2 Nitrogen Mustard
(atkytating
agent)
000762
Metphatan*
008806
MEN
269148
(HCt)
Menogarit
Merbarone
compound (naturat
5-Carboxyanitino-2-thiobarbituric
153858
acid
336628
Mercaptopurine*
6-MP, MP
lsmipur,
Leukerin,
Leupurin,
Mercateukin,
6-Mercaptopurin,
6-Mercaptopurine,
Mercapurin,
Mern, Purinethiot,
Purinethot,
6-Thiohypoxanthine,
6-Thiopurine,
6-Thioxopurine
(antimetabotite)
000755
6-Mercaptopurine
riboside
6-MPR
6-Mercaptoinosine,
6-Mercaptopurineribonucteoside,
6-Thioinosine
004911
139490
000740
See S=stine
095441
MeTHHF
Nethotrexate*
NTX
Methyl CCHU
Methyl-G
Methyt
methanesutphonate
Methytene
Dimethane
Methyl-GAG, Methylgtyoxal
hydrazone dihydrochtoride
Mitoguazone, Mitoguazone
bisguanytmonohyclrate,
dihydrochtoride
032946
Methyl methanesutfonate,
methane sutfonate
MethyL-
050256
Sutfonate
22
Table of Contents
Manuals
CHENOTHEP,
APELIT] C DRUGS
Generic
Name
Short
Names
s,mor,,y_ar,,d
Brand
or Trade
Names
+NSC No.
6-Nethylmercaptopurine
riboside
6-MMPR
6-Methyt
MP-riboside,
Methytthioinosine,
6-Methytthiopurine
riboside,
$Q 21,977
(biochemicat
modulator)
040774
Metoprine
DDMP
Detcronot
007364
Meturedepa
AB-132,
Miltefostine
He-PC
(antimetabolite)
Dimethyturethimine,
Turloc
051325
Hexadecylphosphochotine
Mithramycin
Pticamycin
Mitindomide
CAS I0403-51-7
Mitocarcin
24281 (antibiotic)
284356
MitocLomine
114575
Mitocromin
B 35251 (antibiotic)
077471
Mitogitlin
069529
Mitoguazone
See Methy[
Mitomatcin
Antibiotic
113233
026980
Mitopodozide
2-ethythydrazide,
Proresipar,
SP-I
072274
Mitosper
31595C
117032
o.p'-DDD,
o.p'-DDE
CB-313, Chloditan,
Chtodithane,
Lysodren, Mitotan
(miscettaneous
agent)
038721
DHAD, DHAQ
CL-232,315,
Dihydroxyanthracenedione dihydroch[oride,
Novantrone
301739
Nitozolomide
Azo[astone
353451
Mopidamo[
RA-233
Nafazatrom
BAY G6575
Niton_/cin*
Mitotane*
Mitoxantrone
(HOt)*
Nafidimide
BIDA
Podophyttic
77
acid,
308847
Nitrofurazone
Furacin
Noccx:lazote(BeLgium)
R 17,934
238159
Noga[amvcin#
U-15167
070845
Novatrone
Synthetic
Oxisuran*#
W-6495
antineoptastic
anthracenedione
356716
23
Table of Contents
Manuals
CHENOTHERAPEUT
| C DRUGS
synon_=and
Generic
Name
Short
Names
Brand or
Trade Names
+IISC Iio.
Paclitaxe[
Taxot
125973
PALA
CI-882,
N-Phosphonacetyt-L-Aspartate
disodium,
Sparfosate
Sodium
(miscettaneous
agent)
224131
Pancratistatin
349156
PCNU
Nitrosourea
PeLio_cin
Otigomycin
095466
B (antibiotic)
076455
Penbero[
Pencto_nidine
338720
Pentamethytmelamine HCI
PMM
Pentamustine
NCNU
Satisburystin
324595
Pentosan
Polysu[fate
Sodium
Pentosan
626201
Pep[o_cin
Sulfate
Peptochemio
118742
NK 631,
sulfate
PepLeomycin
PTC
Phenesterine
Fenesterin,
Phenestrin
Phetharbita[
Fedibaretta,
Pyrictal
Phosphoramide
mustard#
Photofrin
PDA
II
Fenestrin,
Phenesterin,
N-Phenytbarbitol,
104469
Phenidiema[,
Phosphamide
See Porfimer
069945
Sodium
603062
Phytlanthoside
Pibenzimol
085043
328426
HCf
Bisbenzamide,
Bisbenzimidazote,
Hoechst No. 33258
322921
135758
Piperazinedione
compound
PZD
Actinomycete
fermentation
Compound593A, Crystalline
(miscellaneous
agent)
Pipobroman*
PIBR
025154
Piposulfan
PISU
A-20968, Ancyte#
047774
Anthrapyrazote Dihydrochtoride,
Oxanthrazole, Oxantrazote HCt
349174
024559
Piroxantrone HCf
Plicamycin*
Porfimer Sodium
MITH, MTH
product,
antibiotic
24
II,
Table of Contents
Manuals
CHENOTHERAPEUT
IC DRUGS
svnon_ and
Generic
lame
Short
Porfiromycin
Names
PORF
Prednimustine
Pyrazine
Names
+MS(; No.
ENT-50825, N-Methytmitcxwcin
C, Porfiromycine, Regamycin#, U-14,743
056410
Sterecyt
Procarbazine*
Puromycin
Brand or Trade
(HCf)
(HCI)
diazohydroxide
Pyrazofurin#
PRZF, PZF
lbenzmethyzin
hydrochtoride,
Matutane,
Methythydrazine,
Natulan,
Ro4-6467/1
(misce[taneous
agent)
077213
CL-16,536,
P-638,
mycin, Styloc_/cin,
003055
Sodium N-Nitroso-Pyrazinamine
361456
Antibiotic
A 23813,
Pyrazomycin,
47599
143095
Pirazofurin,
Pyrazotoacridine
Pyrazoto-Imidazote
compound
366140
IMPY
Razoxane
Pyrazoto
(2,3-a)
IC[-59118,
Rhizoxin
RZN
Riboprine*
IPA
imadazotidine
ICRF-159,
051143
Tepirone
129943
332598
SO 22558
105546
Rifampin
Ba 41166/E,
(antibiotic)
Rubidazone
See Zorubicin
L-5103,
Rifadin,
Rimactane
hydrochloride
113926
164011
Selenium
Semustine
MCCNU, MCNU,
MeCCNU
Simtrazene#
Sparfosate
Sodium
nitro-
CL 26193
095441
083799
See PALA
224131
U-19183
059729
Spiro-32
192965
Spi roc_ustine
Spirohydantoin
mustard#
(atkylating
agent)
172112
Spiroptatin
TNO-6
311056
SR 2508
See Ancillary
Sparsomycin
Spirogermanium
(HCf)
SPG
drugs
StrePtoniQrin
Bruneomycin,
Methyl streptonigrin,
Nigrin,
Rufochromomycin,
Rufocromomycin, 5278 R.P.
045383
Streptozocin
STR, Strept,
STZ, SZ, SZC
Streptozoticin,
Streptozotocin,
U-9889,
Zanosar,
(nitrosourea)
(atkylating
agent)
085998
25
Table of Contents
Manuals
CHENOTHERAPEUT
]C DRUGS
Generic
Marne
Short
Mames
synon_=end
+MSC Io.
Strontium
Sutofenur
Suramin
LY 186641
Sodium
Antrypot,
Germanin,
Naphuride
Tatisomycin
BU-2231A,
Tatlysomycin
Taxol
(See Pactitaxet)
034936
A#
Taxotere
Tazobactam
TCN
See Triciribine
beta
tactamase
phosphate
Tegafur
FT
Florafur,
Ftorafur,
Teniposide
EPT, PTG
Epipodophyltotoxin,
Thenytidine-Lignan-P,
VM-26, Vumon (ptant
280594
Ftuaid,
Ftuorofur,
FT-207,
Futraful,
MJF-12264
Thenytidene,
Vee M-26,
atkatoid)
148958
122819
Vehem,
Terephthatamidine
Teroxirone
296934
D-Tetrandrine
Tetrandirine,
077037
Tetraptatin
Ormaptatin,
Thaticarpine
TC
Theprubicin
THP
Thiamiprine
ITG
Thioguanine*
TG, 6-TG,
TT-G
Thiotepa*
Thymidine
Tiazofuri
Tetrandrin
U-77,233
Tatiblastine,
Thaticarpin
BW-57-323,
TT-6,
methytamidinotphenyl-)
4 HCt, Symetamine
363812
Thalibtastine,
Ouaneran,
057155
Tiamiprine
068075
038887
6-Mercaptoguanine,
Tabtoid,
6-Thioguanine,
Tioguanin
(antir_tabelite)
000752
STEPA, TESP,
TESPA, Thio-TEPA,
TSP, TSPA
006396
Deoxythymidine,
5-Nethytdeoxyuridine,
Thymidin,
Thymine deoxyriboside
021548
TCAR
CI-909,
286193
Ribexamide
26
Table of Contents
Manuals
CNENOTHERAPEUT
I C DRUGS
Generic
Name
TiC-mustard
Short
BIC,
Names
BTIC, TIC
Sy_x_u ar_
Brand
or
Trade
Names
+NSC Bo.
Imidazote
mustard,
Imididazotecarboximide,
TIC NH2 (misc.
agent)
082196
Timp-2
THCA
TNCA
Topotecan
HCf
Citosta[,
Nethyt ether,
Trimethytcotchicinic
acid,
L-tartrate
(1:1)
Hycamptamine,
Toyocamycin
036354
methyl
ester,
SKF 104864-A
609699
Antibiotic
1037, Antibiotic
E 212,
Toyokamycin,
Una_/cin B, Vengicide
063701
See Baker's
139105
Treosulfan
Triazinate
Triazine
antifoL
antifo[
127755
Triciribine
Phosphate
TCN, TCN-P
Tricyctic
nucteoside
5'-phosphate#,
Tricyctoside
phosphate
280594
Triethytenemetamine
TEN, TET
009706
Trigtycidylurazol
TGU
Anaxirone
Trimetrexate
THTX
CI-898,
Trityt
cysteine
R-246,
332488
Trimetrexate
S-trityt-L-cysteine,
atanine
glucuronate
352122
Tritytthio-
083265
Trofosfamide
Tubercidine
Uracil
Hustard*
UHM2
Antibiotic
XK 101-1, Aptisot,
7-Deazaadenosine,
Sparsomycin A, Tubercidin,
U-10071,
12,540
056408
U-8344, Uracil,
Uramustin,
(atkytating
agent)
034462
Uredepa
AB-IO0,
Avinar#,
Urethane
Ethyl
carbamate#
Uridine
Uracil
riboside,
Vapreotide
BNY-41606,
Uramustine
Urethimine
037095
000746
Urd,
Uridin
020256
RC-160
Vidarabine*
Ara-A
Adenine arabinoside,
Ara-adenosine,
Arabinosytadenine,
CI-673,
Spongoadenosine,
Vidarabin,
VidarabinThito,
Vira-A,
Vitarabin,
Vitarin
404241
Vinblastine*
Sulfate
Vetban, Vinbtastine_
Velsar,
Vincateukobtastine
sulfate,
29060-LE
(vinca plant alkaloid)
(mitotic
inhibitor)
049842
27
Table of Contents
Manuals
CHF.NOTXERAPEUTI[C
DRUGS
Generic
Marne
Short
Vincristine*
SuLfate
Names
Vindesine
or Trade
Names
+MSC No.
DAVA, DVA
Sulfate
Desacetytvinbtastine
Etdisine,
LY-099094
SuLfate
49040
Vinteurosine
SuLfate#
Leurosine,
Vinoretbine
VNB
Vinrosidine
SuLfate#
Vinzotidine
amide sulfate,
245467
32645
528004
LY 119863
Vingtycinate
Vinteurosine,
Navetbine
Leurosidine
VZL
Sutfate
sulfate,
3678t
LY-104208
(vinca
WR 2721
plant
aLkaLoid
See Ancillary
derivative)
drugs
Yoshi-864
102627
Zeniptatin
Cb 286,558
Zidovudine*
AZT
See Azidothymidine
Zinostatin
NCS, NZS
geocarcinostatin,
Vinostatin
RBD, RUB
Zorubicin
067574
Compound 112531
Vindesine
SuLfate
Vinepidine
Brand
(HCf)
28
602670
Neocarzinostatin#,
157365
164011
Table of Contents
Manuals
CONBIMATIOU REGINEMS
There are manycombinations
of antineoptastic
drugs and hormones in general use. Teaching
institutions
are continuously
estabtishingandtesting
protocols
usingnew
combinations
of drugs. Listed in this
segment are a few combinations
so that you wilt
understand
how these combinations
are named. As a registrar
you should familiarize
yourself
with the antineoptastic
drugs used in your hospital's
oncology department
to
ensure the proper
identification
of its drug combinations.
ABVD
Adriamycin,
AcFuCy
Actinomycin,
ADOC
Adriamycin,
BACOP
Bteomycin,
Adriamycin,
B-CAVe
Bteomycin,
CCNU, Adriamycin,
B-DOPA
BLeomycin,
Dacarbazine,
CAF
Cyctophosphamide,
Adriamycin,
5-Ftuorouracit
CAMF
Cyctophosphamide,
Adriamycin,
Methotrexate,
5-Fluorouracit
CAMP
Cyctophosphamide,
Adriamycin,
Methotrexate,
Procarbazine
CAP
Cyctophosphamide,
Adriamycin,
Cisptatin
CAV
Cyctophosphamide,
Adriamycin,
Vincristine
CAVV
CyctophosDhamide,
Adriamycin,
Vincristine,
CCVPP
CCNU, Cyctophosphamide,
CFP
Cyc tophosphamide,
5- F tuorouraci
CHAD
Cyctophosphamide,
Hexamethytmetamime,
Adriamycin,
DDP
CHAP
Cyctophosphamide,
Hexamethytmetamine,
Adriamycin,
Cisptatin
CHtVPP
Chtorambucit,
CHOP
Cyctophosphamide,
CMC
CCNU, Methotrexate,
CNF
Cyctophosphamide,
Methotrexate,
5-Fluorouracil
CMFVP
Cyctophosphamide,
Methotrexate,
5-Ftuorouracit,
COAP
Cyctophosphamide,
Oncovin,
C-MOPP
Cyctophosphamide,
Methotrexate,
CON
Cyctophosphamide,
Oncovin,
Methotrexste
CONLA
Cyctophosphamide,
Oncovin,
Methotrexate,
Leucovorin
CONP
Cyctophosphamide,
Oncovin,
Methotrexate,
Prednisone
COP
Cyctophosphamide,
Oncovin,
Prednisone
COP-BLAH
Cyctophosphamide,
Oncovin,
Prednisone,
CVP
CyciophosrJhamide,
Vincristine,
Cyta
BOM
Vincristine,
Bteomycin,
Vinbtsstina,
5-Ftuorouracit,
DDP, Oncovin,
Dacarbazine
Cyctophosphamide
CyctoDhosDhamide
Cyctophosphamide,
Oncovin,
Prednisone
Vinbtastine
Ormovin,
Prednisone,
Vincristine,
Vfnbtastine,
t,
Adriamycin
VP-16
Procarbazine,
Prednisone
Predni sone
Procarbazine,
14-Hydroxydaunomycin
Prednisone
(Adriamycin),
Oncovin,
Prednisone
CctoDhosphamide
Methotrexate
Adriamycin,
Procarbazine,
Bleomycin,
Prednisone
29
Prednisone
Prednisone
Oncovin,
and citrovorum
Vincristine,
factor
Prednisone
rescue,
Doxorubicin,
Ara-C
Procarbazina
Table of Contents
Manuals
Cyclophosphamide,
DDP-CHAD
Vincristine,
Adriamycin,
Dacarbazine
DDP, Cyctophosphamide,
Hexamethytmelamine,
Adriamycin,
DDP-MECY
DDP, Nethotrexate
Leucovorin
DVB
Cisptatin,
Vindesine,
Bteomycin
DVH
Cisptatin,
Vindesine,
Methyt
D-ZAPO
Daunorubicin,
EBAP
Etdisine,
FAC
5-Fluorouracit,
Adriamycin,
FACP
5-Ftuorouracit,
Amethopterin,
FAR
5-Fluorouracil,
Adriamycin,
Hitomycin
FEC
5-Ftuorouracit,
Epirubicin,
Cyclophosphamide
FOHi
5-Ftuorouracil,
Oncovin,
HEXA-CAF
Hexamethylmelamine,
HABOP
Mechtorethamine,
MACC
Hethotrexate,
Adriamycin,
Cyctophosphamide,
CCNU
MACE
Hethotrexate,
Adriamycin,
Cyctophosphamide,
Etoposide
HACOP-B
Methotrexate,
Ooxorubicin,'CycLophosphamide
MAID
Mesna,
M-BACO0
Methotrexate,
MMV
Hitomycin,
MOF
Mitomycin
MOF-S
NeCCNU, Oncovin,
5-Ftuorouracit,
MOPP
Nechtorethamine,
Oncovin,
MTX-CF
Hethotrexate
MVAC
Methotrexate,
PAC
Cisplatin,
Adriamycin,
PEB
Cisptatin,
Etoposide,
POC
Procarbazine,
POMP
6-Mercaptopurine,
PRO-MACE
Prednisone,
Methotrexate,
ProHACE-MOPP
Prednisone,
fottouedby
Methotrexate,
Adriamycin,
Cyctophosphamide,
Epipodophyttotoxin,
Hechtorethamine,
Oncovin, Procarbazine,
Prednisone
PV8
Cisptatin,
TBP
Thiotepa,
with
Ara-C,
BCNU, Adriamycin,
Prednisone,
Cyclophosphamide
Cctophosphamide,
Bteomycin,
Amethopterin,
Bteomycin,
lfosfamide,
Oncovin,
5-Fluorouracit
Prednisone
, Vincristine,
Prednisone,
Bteomycin
DTEC
Adriamycin,
Methotrexate,
Cyctophosphamide,
Oncovin,
Dexamethasone
Vincristine
or MeCCNU, Oncovin,
5-Ftuorouracit
Streptozotocin
Procarbazine.,
citrovorum
Vinbtastine,
factor
Prednisone
rescue
Adriamycin,
Cisptatin
Cyctophosphamide
Bteomycin
Oncovin,
CCNU
Oncovin,
Bteomycin,
Prednisone
Mitomycin
Adriamycin,
Vinbtastine,
Oncovin
Prednisone
Cyclophosphamide,
Doxirubicin,
Cyctophosphamide
5-Azacytidine,
with
rescue,
DDP
Methotrexate,
Adriamycin,
Bteomycin
Prednisone
3O
Prednisone
Cyptophosphamide,
Epipodophyttotoxin,
Table of Contents
Manuals
COItlNATIOU
RE(;INEIIS (Cont'd)
VAt
Vincristine,
kctinoa_/cin
D,
Cyctoohosl=hamide
V&P
Vincristine,
Adria_/cin,
Procarbazine
V&TH
Vinbtastine,
Adriamycin,
Thiotepa,
VBAP
Vincristine,
8CNU, Adriamycin,
VSP
Vinblastine,
Steomycin,
_P
Vircristine,
.Nethotrexate,
Hatotestin
Prednisone
C_sptatin
Prednisone
31
(systemic
consolidation
therapy)
Table of Contents
Manuals
32
Table of Contents
Manuals
NOTES
33
Table of Contents
Manuals
34
Table of Contents
Manuals
Section 2
ANCILLARY DRUGS
Ancillary drugs are medications whose actions are not directed at the patient's malignancy per se
but which enhance the effects of the cancer-directed
therapy.
For example, ancillary drugs may
modulate the actions of specific chemotherapeutic
agents by increasing their effectiveness in
destroying tumor cells or by decreasing the potential for certain side effects. Ancillary drugs may be
also used to control symptoms related to the patient's cancer or its treatment, or to manage other
coexisting medical problems. Ancillary drugs are NOT to be coded as cancer-directed therapy.
Ancillary Drugs Administered
with Chemotherapy
Table of Contents
Manuals
Radiosensitizers
and Radioprotectants
In some instances, as with chemotherapy, the effects of radiotherapy may be modulated by agents
which have no antitumor activity themselves. Radiosensitizing drugs augment the cytotoxicity of
radiotherapy, and radioprotective agents diminish damage to normal, non-cancerous tissues. Many
antineoplastic drugs, including the anthracyclines, 5-fluorouracil, and methotrexate, can enhance the
cell killing effects of radiation; this is the basis for many combined-modality regimens. Other agents
have been specifically synthesized as chemical modifiers of radiation effects and are under study in
clinical trials.
The energy from therapeutic radiation ejects electrons from molecules in the target tissues. These
electrons interact with other molecules in the cell to form free radicals which are unstable and highly
reactive. DNA damage resulting from free radical formation contributes to cell injury and death.
Thus any process which increases the DNA damage associated with free radical formation or inhibits
damage repair results in radiosensitization.
Radiosensitizers are difficult to classify because they often have more than one mechanism of
action. BUdR (Bromodeoxyuridine),
an agent that is similar to the DNA precursor thymidine, is
under study for brain tumors. Agents with electron affinity, such as metronidazole and misonidazole,
are also in clinical investigation as radiosensitizers.
Other agents in preclinicaland
clinical studies
include SR 2508, Ro 03-8799, RSU 1069, and L-BSO.
Drugs or processes which interfere with free radical formation or facilitate repair of cellular
damage result in radioprotection.
WR-2721 is an interesting investigational
new agent in this
category because it appears to have activity not only as a radioprotectant but also in prevention of
nephrotoxicity and neurotoxicity associated with cisplatin therapy.
Growth Factors
Suppression of blood cell production by the bone marrow and the resulting cytopenia is the side
effect which most often limits the dose of chemotherapy that a patient can receive or necesitates a
reduction in standard doses of chemotherapy. This is an important consideration because, for many
cancers, tumor response to treatment depends on the amount of drug administered over a course of
therapy (dose intensity).
Research studies of blood formation in bone marrow cultures have identified substances (or
growth factors) which regulate blood cell growth and development.
For example, GM-CSF is a
colony stimulating factor (CSF) which promotes growth and development of clusters or "colonies" of
blood cells which will become granulocytes and macrophages. G-CSF is a growth factor which acts
at a later step in myeloid development and stimulates colonies which will produce predominantly
granulocytes.
Erythropoietin stimulates the production of red blood cells.
Recombinant DNA technology has allowed scientists to insert the genes responsible for growth
factor production into bacteria, so that growth factors for clinical use can be produced by
pharmaceutical companies from bacterial cultures. GM-CSF and G-CSF are now administered to
patients who develop severe neutropenia as a side effect of chemotherapy, to facilitate bone marrow
recovery and shorten the period of neutropenia.
They also have been used to lessen bone marrow
toxicity and allow administration of higher doses of chemotherapy.
36
Table of Contents
Manuals
37
Table of Contents
Manuals
38
Table of Contents
Manuals
AINCILLARY DRUGS
Generic
Name
Short
Names
Acetaminophen
Synon_and
grand
or Trade
(reduces
Acetazotamide
ACZ
Oiamox (carbonic
(diuretic)
5052
Acyctovir
Zovirax
Adicittin
Cephatosprin
Albuterol
Proventil,
Sodium
MK-217
Atizapride
+NSC No.
fever)
Acetytcysteine
Atendronate
Names
anhydrase
inhibitor)
111160
g (antibiotic)
Ventotin
(bronchodilator)
(suppressant;
bone resorption)
(anti-emetic)
Altopurinot*
ALLO
Allopur,
Atisuril,
Bloxanth,
BW-56-158, Epidropal,
Fotigan,
Gotax, HPP, Lopurin,
Milurit,
Uricemit,
Uriprim,
Urosin,
Zyloprim,
Zyloric
Atprazotam
Xanax,
Amifostine
Ethiofos#,
Ethyot,
Gammaphos, WR-2721
(radioprotector)
(prevents
nephrotoxicity,
neurotoxicity)
Aminobenzoate
Potassium
U-31,889
(sedative)
(prevents
Amiodarone
Batanopride HCI
BMY-25601-01
Benznidazo[e
(chemosensitizer)
Benzquinamide
Ouantril,
Beta
Solatene
Borocaptate
Sodium B 10
Bromodeoxyuridine
296961
(analgesic)
Aminosyn
Carotene
001390
Borotife,
agent)
acivicin-induced
toxicity)
P-2647
(anti-emetic)
(ultraviolet
064375
screen)
5-Bro_eoxyuridine,
5-Bromodesoxyuridine, Bromouracit deoxyriboside,
5-Bromouracit deoxyriboside,
Broxuridine (radiosensitizer)
CaLcium Carbonate
CalciumGtuconate
Component of Calcet,
(calcium replenisher)
Calcitonin*
Calcimar,
Cibacatcin
39
(regulates
calcium)
038297
Table of Contents
Manuals
ANC]LLARY DRUGS
svnon_sand
Generic
Name
Short
Names
+NSC No.
Chtornaphazine*
CB-1048, Chlornaftina,
Chtornaphazin,
Chtornaphthin,
Chtoronaphthina,
Chtoronaphthine,
Cloronaftina,
Erysan, Nafticlorina,
Naphthytamine
mustard, R-48
062209
Chtorprornazine*
Chtor-PZ#,
Thorazine
antipsychotic)
Cimetidine
Tagamet
Ctonidine
Catapres-TTS
therapy)
Codeine
Analgesic
Coenzyme Q
Reduces myoctonic
seizures
Combid spansule
(See Isopropamide
Mateate)
Iodide
CSF-GN
CSF-GN (H)/Yeast,
Recombinant
Recombinant Human GM-CSF
(anti-emetic;
(controls
hot
flashes
in breast
cancer
(narcotic)
Granulocyte-Colony
and Prochtorperazine
(lmmunex),
Stimulating
613795
Factor
CSF-GN
CSF-GR ([ncnunex)
Granutocyte-Cotony Stimulating Factor
(Amgen)
614629
CSF-GM
(Schering) Plough
CSF-Granutocyte-Macrophage
617589
CSF-GM
Granulocyte-Macrophage-Cotony Stimulating
Factor (Recombinant Human) (E.coti)
CSF-GM E.coti (Hoechst)
622183
CSFoMacrophage
Macrophage-Cotony-Stimutating
(M-CSF) Cetus
625377
Factor
CSF-Macrophage
635258
Danazo[
Dexamethasone*V
Aeroseb-Dex,
Decaderm, Decadron Tablets,
Decaspray,
Component of Deronit,
Component of Dexacidin,
Dexasone, Oexone,
Hexadrot ELixir,
Hexadrot Tablets,
Maxidex, Component of Maxitrot,
Component of Tobradex (gtucocorticoid)
345211
Deferoxamine
Prevents
527604
Defosfamide
Desmophosphamide
040627
Oemethylmisonidazote,
Ro-5-9963,
SR-1530, (radiosensitizer)
261036
Desmethylmisonidazote
V
]fused
therapy.
DES-ME
in the treatment
For art other
cardiac
ofthemtignanciesaentionedin
cancers, consider ancittaryuntess
4O
toxicity
the intr_nd,__,ctiononp.
specifically
stated
37 (bold),
code ashormonat
to behormonat
therapy.
Table of Contents
Manuals
ANCILLARY DRUGS
sv_n_
Generic
Name
Short
Diethyldithiocarbamate
Diltiazem
Na_s
HCl
Dimepranot
grand
Cuprol,
Names
Dithiocarb,
+NSC No.
Thiocarb
Cardizem (vasoditator,
influx
inhibitor)
Acedoben
Diphenidol
038583
catcium
Component of ]soprinosine
(immunomodutator)
Anti-emetic
Diphenhydramine
HCf
Benadryl,
Component of
Benytin,
Component of Catadry[
(antihistaminic)
Dipyridamole
Persantine,
(coronary
Domperidone
R-33-812
Droperido[*
]napsine,
R-4749
Elliot's
and
or Trade
Ra-8
vasodilator)
515776
(anti-emetic)
Component of
Innovar,
McN-JR-4749,
8 solution
614386
EMLA
Endorphin
Analgesic
Erythropoietin
(See
Etanidazole
Radinyl,
(hypoxic
SR 2506
celt radiosensitizer)
301467
Ethacrynic Aci d
085791
Ethiodized Oil*
Ethiodot-131#
Ethiofos
See Amifostine
(radioprotector)
Etidronate
Disodium
Fansidar
Fentanyl
biological
Didronet
response
modifiers)
(radio-opaque medium)
(calcium
296961
regulator)
Sulfadoxine/Pyrimethamine
Citrate
Analgesic;
narcotic
F_uconazole
Diflucan
(antifunga[)
Fluosot-DA
Radiation-sensitizing
Fturbiprofen
Furosemide*
Disa[,
G-CSF
Lasix,
41
LB-502
agent
(diuretic)
Colony
Table of Contents
Manuals
ANCILLARY DRUGS
s,rn_v_ anti
Generic
Name
Short
Ganciclovir
NameS,
DHPG
Cytovene
patients,
+NSC No.
(therapy
for immunosuppressed
bone marrow recipients)
Glycine
GM-CSF
Granutocyte
factor
Gold Au 198
Aurcoloid-198#,
Aureotope# , Auroscan-198#
(diagnostic
aid, liver
imaging;
radioactive
agent)
Granisetron
BRL-43694
Guanfacine HC[
Tenex
Hatoperidot
Haldol,
Hematoporphyrin
Heroin
Derivative
HCI
Hydrazine
Emits
macrophage
(serotonin
Diacetytmorphine
Diamorphine HCI.
Sulfate
stimulating
antagonist;
McN-JR-1625,
fluorescence
colony
R-1625
in
anti-emetic)
(antipsychotic)
neoplastic
cells
dihydrochloride,
Heroin hydrochloride
302357
(anti-cachexia)
150014
Hydromorphone HCf
Ditaudid
Hydroxyzine
Atarax,
Component of Ataxaroid,
Component
of Cartrax,
Component of Enarax, Component
of Marax, Quiess, Vistari[,
Component of
Vistrax
(tranquilizer)
Hyperbaric
HCl
Oxygen
Idoxuridine*
(analgesic;
Radiation-sensitizing
[DU, IDUR, ldUrd,
IUdR, 5-[UDR
narcotic)
agent
Allergan
211, Oendrid,
Emanil,
Herpesil,
Herpidu,
Herplex,
Herplex
Liquifilm,
Idexur,
Idoxuridin,
Iducher,
ldulea,
ldu-Ocutos,
Iduridin,
Iododeoxyuridine,
Joddeoxyuridin,
Kerecid,
Ophthalmadine,
SK&F 14287,
Stoxil,
Synmiol (radiosensitizer)
Indomethacin*
Indocin
calcium)
lnosine
Component of Isoprinosine
lsoprinosine
]munovir
(Combination
product:
Acedoben and ]nosine)
Isopropamide
Itraconazole
Ketorotac
L-BSO
Iodide
(anti-inflammatory;
(analgesic)
lowers
Tromethamine
R-51,211,
Sporonax
(Rx of Candidiasis)
Torado[
42
as Con_oid spansule)
(antifungai)
(anti-inflammatory;
_-Buthionine
blood
see Dimeprano[
039661
sutfoximine
ana[gesic)
(radiosensitizer)
326231
Table of Contents
Manuals
ANCILLARY DRUGS
SW,onVus
and
Generic
Name
Short
Leucovorin
(calcium)*
CF, C.F.
CL
Levonantradol
(HCt)
Lidocaine
Lithium
lames
Brand or Trade
Names
+NSC No.
Calcium fotinate,
Catcium teucovorin,
Citrovorum
factor,
Folinic
acid,
Lederfoline,
Leucosar,
Wettcovorin
003590
CP-50,556-1
331615
(analgesic)
Anestacon,
Lidomantte-HC,
component of
of, Xyiocaine
(Local anesthetic)
Carbonate
C.P. 15,467-61,
Eskatith,
Lithane,
Lithobid,
Lithonate,
Lithotabo,
(antimanic)
016895
L-Leucovorin
Lonidamine
Radiation-sensitizing
Lorazepam
Ativan,
Loxoribine
Immunostimutant;
Magnesium Sutfate
Anti-convulsant;
Laxative;
electrolyte
replenisher
Mannitol
Diuretic
Mannomustine
(anti-emetic)
vaccine
adjuvant
Degrano[,
Mannitot
Mannit-Lost,
Mustard
NDL-72222
Serotonin
antagonist;
anti-emetic
NDL-73147EF
Serotonin
antagonist;
anti-emetic
Meperidine
BCM
tb/-4036
agent
HCL
009698
Mesna*
Methadone
Mannit-Mustard,
XethoxsaLen
Methylphenidate
Metoclopramide
(HCt)*
Metronidazote
113891
8-MOP, Oxsoraten
HCI
(photosensitizer)
Ritalin
MCP
AKR-3070-C,
(anti-emetic)
Octamide
Radiosensitizer
(See
AIDS complications)
43
PFS, Regtan
Rx of
Table of Contents
Manuals
AMCILLARY DRUGS
s_om_ and
Generic
Name
Short
Metyrosine
Mantas
Brand or
Trade Names
Anti-hypertensive;
therapy
malignant
pheochromocytow
Hidazotam
HCf
for
Ro 21-3981/003,
Versed
(anesthetic;
CNS depressant)
Nisonidazote
NNI
Ro-7-0582,
SR-1354,
(rediosensitizer)
SRI-1354
261037
Molybdenum
Metabolic
Rorph,ineSutfate
Astramorph,
Ouramorph, HS Confine,
NSIR (analgesic;
narcotic)
Nabitone
Cesamet,
Natoxone
HCf
therapy
Antagonist
to narcotics
Nattrexone
EN-1639A,
Trexan
Naproxen
Naprosyn,
analgesic;
RS-3540 (anti-inftammatory;
antipyretic)
Niacin
Niac, Nicobid,
Nicotar
patients
on parenteral
Nifedipine
Calcium
channel
Aventyt
HCf, Pamelor,
Nortriptytine
HCl
Ondansetron
HCf
GRF 38032F,
anti-emetic,
Pamidronate
Disedium
Aredia
Papaverine
HCt
(antagonist
to narcotics)
(therapy
nutrition)
blocking
agent
38489 (antidepressant)
Ondanserin,
Zofran
antischizophrenic,
(suppressant;
for
(serotonin
anxiotytic)
bone resorption)
BL 191, Trental
(vasodilator)
(radiation-sensitizing
agent)
Perphenazine
Component of Estrafon,
Triavit,
Tritafon
Pimonidazote
Ro 03-8799
Piperazine
Antiren,
Dispermine,
Eraverm,
Hexahydropyrazine,
Lumbricat,
Piperazidine,
Piperazin,
Pipersot,
Pyrazine
Hexahydride,
UN 2579,
UN 2685, Uviton,
Vermex, Component of
Wazine-34,
_urmirazin (anthelmintic)
Piroxicam
Probenecid
Glycol
(aypocatcemia)
Cerespann, Component of
Copavin, Pavabid
(smooth muscle relaxant)
Pentoxifyttine
Polyethylene
antagonist;
PEG
Carbovax
Pturacot
Component of
(rediosensitizer)
Sentry, Cotyte,
component of,
E400, E600, E1450
Uricosuric;
uric acid
increases
excretion
of
in respiratory
acidosis
44
000/.74
Table of Contents
Manuals
ANCILLARY DRUGS
synon_sand
Generic
Name
Short
Names
Prochtorperazine*
Prochlorperazine
Promazine
Compazine,
(anti-emetic)
Raleate
Pyridoxine
Sparine
HCf*
Pyrazinamide
as Combid spensute
(antipsychotic)
PZA
HC._.I
Beesix,
Hexa-Betatin,
(reduces neurotoxicity)
Vitamin
B6
B_ 50-63,
Chtoridin,
Chloridine,
Darapram,
Daraprim,
Daraprime,
Diaminopyritamin,
Erbaprelina,
Component of Fansidar,
Malocide,
Pirimecidan,
Pirimetamina,
Tindurin
(HCl)
Arab,
Ouinidine
R-Verapamit
Component of Eskatrot#
P_rimethamine
Ouinacrine
+IISC Ii?.
HCf*
Promethazine
OUIN
Acrichin,
Akrichin,
Haffkinine,
Ouinactine
Acrinamine,
Antima[arina,
]ta[chine,
Chemosensitizing
HCf
Rhenium-186
Calcium
HEDP
channel
blocking
Ro-03-8799
Pimonidazole
RSU 1069
Radiosensitizer
Serotonin
GR 38032
Sodium Chloride
Ayr (chemoprotective
nephrotoxicity)
Sodium Fluoride
Ftoridine
Xaridium,
Sodium lodide
I 131 ldotope
632821
(radiosensitizer)
F (antagonist)
Ftuorot,
Zymaf tuor
Radioactive
Sodium Thiosulfate
agent
Hydroxyethylidene
diphosphonate
(palLiative,
skeletal
metastases)
Cancer preventative
P 32
014229
HCL,
agent
Riboflavin
Sodium Phosphate
Acriquine,
Atabrine
Nepacrine,
003061
Sulfactol#,
of Tinver
agent,
agent
reduces
Pergantene,
diagnostic
077385
aid
045624
Sparfloxacin
Spiramycin
SR 2508
Leucomycin
SN
See Etanidazote
45
055926
(radiosensitizer)
301467
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Manuals
ANCILLARY DRUGS
synony_ and
Generic
Name
Short
Names
Sucratfate
Carafate
Sutfadiazine
Sutfonamide
Sutfamethoxazote
Azo Gantanol,
component of, Bactrim,
compormnt of,
Cotrim,
component of, Gantanot,
Septra,
component
of, Sutfatrim,
component of
Sutindac
Ctinorit
Tetrahydrocannabinol
THC
Theophyttine
(anti-ulcerative)
Duptex,
component of#
(anti-inflammatory)
Cannabinot,
Detta-9-THC,
Dronabinot,
Narinot,
SP-104 (anti-emetic)
Bronchoditator
Triftupromazine
HCf*
Trimethobenzamide
Trimethoprim
Vesprin
He._!
TNP
Tigan
(antipsychotic)
(anti-emetic)
Bactrim,
component of, Cotrim,
component of,
Protoprim,
Septra,
component of, Sutfatrim,
component of, Trimpex
Tropisetron
ICS-205930
anti-emetic)
Urokinase
Ptasminogen activator;
thromboembotytic
therapy
Verapamit
Vitamin
Warfarin
114454
(HC._t)*
(Serotonin
Sodium*
antagonist;
Catan, lsoptin,
Isoptin
hydrochtoride,
]zoptin,
Verapami[
(lsoptrin),
Veteran
(chemosensitizer)
(calcium
channel blocker)
Anti-fibrosis
106568
256325
therapy
Coumadin, Panwarfin
(anticoagulant)
059813
WR 2026
gR 2721
See Amifostine
46
296961
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NOTES
47
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48
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Section 3
DIFFERENTIATION-INDUCING
AGENTS
49
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50
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Manuals
synommsmd
Generic
Name
Short
Names
Brand
or Trade Names
therapy.
+NSC No.
See Introduction.
Soriatane
Dimethyt
Sutfoxicie
1,25-Dihydroxyvitamin
D3
See 8io[ogical
Vit
Tegis_
HMBA
Hexamethytene
diacetamide
Mycophenotic
000763
03
Etretinate
4-Hydroxyphenyl
retinamide
Response Nodifiers
bisacetamide,
Hexamethylene
095580
4-HPR
acid
Nelbex#,
68618
129185
PhenyL Acetate
Retinoic
acid
Vit
Retinyt
Acetate
RA
Accutane,
Isotretinoin*,
Meovitamin
A
acid,
Ro 4-3780,
13-cis-Retinoic
acid,
13-cis-Vitamin
A acid
329481
Abere[,
Airot,
Atl-trans-retinoic
acid,
Dermairol,
Eudyna, Retin-A,
Retinoic
acid, Vitamin A acid
122758
SodiumButyrate
Tretinoin*
Vii
AGENTS
U|THBOTH
CYTOTOO(IC
AMD
DIFFERENTIATING
PROPERTIES
Code as chemotherapy.
Cytarabine
kra-C
Cytosar-U,
Tarabine,
U-19920,
(under
investigation
for Rx of Progressive
Nuttifoca[
Leukoencephatopathy
(PNL))
Azacitidine
5-AC, 5-AZA,
5-AZAC, AZC,
5-AZCR
Antibiotic
U-18,496,
Azacytidine,
5-Azacytidine,
Ladakamycin,
Hytosar
(antimetabotite)
102816
N-NethyLformamide
NNF
Nethytformamide,
003051
5]
Nonomethytformamide
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52
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NOTES
53
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54
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Section 4
BIOLOGIC THERAPY OF CANCER
Biologic therapy or immunotherapy is defined as treatment that produces its anticancer effect by
enhancing
the patient's natural defense mechanisms against cancer.
This is accomplished
by
administering agents that modulate the patient's immune response to his/her tumor, by providing
additional natural immune molecules made through new technologies, or by transferring immune cells
stimulated to act against the patient's cancer.
The drugs, chemicals, or biologic agents used in
biologic therapy are often referred to as biological response modifiers.
Biologic therapy is a new and rapidly developing area of oncology. Research in this area has been
stimulated by increased understanding of the activity of the human immune system and by advances
in biotechnology that have made possible the production of antibodies and other immune molecules
by recombinant DNA methods.
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T cells mature and differentiate in the thymus before dispersing to other lymphoid tissue. In
contrast to B cells which function in humoral immunity, T cells have prominent roles in cellular
immunity. T cells also recognize antigen in a manner quite different from that of B cells. In general,
T cells cannot respond to an antigen without the assistance of other cells. Antigen must be
"processed" by other cells and presented to the T cell as a combination of antigen components with
major histocompatibility complex (MHC) molecules, while B cells can recognize and respond to
unprocessed antigen.
Traditionally, T cells have been classified by function as helper, suppressor, or cytotoxic T cells.
Currently, two major subsets of T cells are identified by the class of MHC molecules required for
antigen recognition. T cells which require Class I MHC molecules (i.e., HLA-A, B, or C) express the
cluster of differentiation CD8 on their cell surfaces, while T cells which require Class II MHC
molecules (i.e., DP, DQ, and DR) express the cluster of differentiation CD4. While cells with helper
and cytotoxic functions can be identified within each subset, CD4+ T cells are more likely to express
helper function, and CD8+ cells are more frequently cytotoxic or are more often capable of
suppressing the immune response of other lymphoid populations.
Null cells are lymphoid cells which express neither T cell nor B cell surface markers. Subgroups
derived from null cells include natural killer (NK) cells, lymphokine-activated killer (LAK) cells,
and cells involved in antibody-dependent
cellular cytotoxicity.
Reticuloendothelial
cells, especially circulating monocytes and tissue macrophages, are also
important components of the immune system. Monocytes are produced and mature in the bone
marrow, enter the circulation, and then exit into tissue where they may die or mature further to
become tissue macrophages.
Macrophages are highly phagocytic cells which engulf, process, and
present antigen components to T lymphocytes.
They also produce monokines (cytokines) which
facilitate T-cell activation and interaction with B cells to induce antibody formation.
Immune-mediated
Cell Destruction
The immune system can cause the destruction of target cells through a variety of mechanisms.
Certain subtypes of antibodies (IgG and IgM immunoglobins), attached to cell surface antigens, can
activate complement, a system of functionally linked proteins that interact to damage the target cell
membrane. Antibodies attached to cell surface antigens can also act as opsonins, making the target
cells more susceptible to phagocytosis by macrophages.
Target cell lysis can occur by direct actions of immune cells. Cytotoxic T lymphocytes (CTLs) bind
to surface antigens on target cells and release cytotoxic substances by the T cell. CTLs are not
damaged during this process; they detach from the target cell and recycle to attack other target cells.
Antibodies to surface antigens on target cells or lectins can serve as a crosslink between target cell
and cytolytic immune cells in antibody (or lectin)-dependent
cellular cytotoxicity. NK cells have the
ability to lyse cells in cultured cell lines without prior immune sensitization to the cells, but they
appear to have little effect on fresh tumor cells. LAK cells develop the ability to kill tumor cells after
exposure to the cytokine interleukin-2 (IL-2).
Many cytokines can mediate cell destruction, either by direct toxicity toward target cells or by
initiating an inflammatory reaction in target tissue.
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Tumor Antigens
When a cell becomes malignant, it undergoes biochemical
changes that may result in the
production of new cell surface proteins capable of distinguishing it from a normal cell. Such tumor
antigens may be seen as foreign by the host immune system and may result in a specific immunologic
response to the tumor cells. In animal models, tumor antigens may be highly specific for an individual
tumor cell line. However, most tumor antigens studied in naturally-occurring
tumors are shared by
different tumors and may even be expressed to a lesser extent by normal cells; these are termed
tumor-associated
antigens.
Tumor infiltrating lymphocytes (TILs) have been isolated from the inflammatory infiltrates of a
variety of human cancers.
TILs with specific cytolytic function have been isolated from human
melanoma and occasionally from renal cell cancer; nonlytic TILs with specific recognition of tumor
antigens have been identified in patients with melanoma and breast cancer. TILs can be activated
and expanded in culture with IL-2.
Immunotherapy
Agents and substances used in biologic therapy, or immunotherapy,
to the way in which they modify the host defense mechanism.
Active Immunotherapy
Active immunotherapy
refers to immunization of the cancer patient with materials designed to
elicit an immune reaction against the patient's tumor. Early attempts at immunotherapy
focused on
nonspecific stimulation of the immune system by bacterial products, in hopes that general immune
stimulation would lead to an increased host immune response to its established tumor. This approach
developed from observations of tumor regression following severe bacterial infections or exposure
to bacterial toxins. Agents used for nonspecific immune stimulation include BCG, MER, C. parvum,
and levamisole.
Prospective randomized clinical trials have failed to support a role for nonspecific immunotherapy
in the cancer treatment, with a few notable exceptions.
The addition of levamisole to adjuvant
therapy with 5-fluorouracil has improved survival in patients with Stages B2 and C colon cancer.
Intralesional
immunotherapy
of cutaneous
metastases from malignant melanoma with BCG has
resulted in good local control, and BCG has been used successfully as instillation therapy for the
treatment of superficial bladder cancers.
Other approaches to active nonspecific immunotherapy
involve administration of cytokines such
as interferon or IL-2 to enhance host immune response.
Interferons
(INFs) belong to a family of
proteins produced by cells in response to viral infection. Three major classes of interferons have been
identified: INF-alpha, produced by leukocytes; INF-beta, produced by fibroblasts and epithelial cells;
and INF-gamma, produced by activated lymphocytes. In addition to antiviral and immunomodulatory
effects, biologic
properties
of interferons
include antiproliferative
activity, regulation
of
differentiation,
interaction with other cytokines, and enhancement
of tumor-associated
antigens.
Recent
interferons
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of solid tumors and hematologic malignancies, including hairy cell leukemia, chronic myelogenous
leukemia (CML) and other myeloproliferative disorders, cutaneous T-cell lymphoma, and Kaposi's
sarcoma.
lnterleukin 2 (IL-2), a cytokine produced by activated T lymphocytes, has several actions of
interest in immunotherapy.
IL-2 stimulates the growth and proliferation of lymphoid cells and causes
the release of a variety of other cytokines; it also enhances cytolytic activity of adoptively transferred
cells (see below). IL-2 has no direct activity against cancer cells.
IL-2 has been used alone and in conjunction with adoptive transfer of lymphoid cells. IL-2 as a
single agent has produced complete and partial responses in patients with advanced renal cell cancer
and melanoma, rlL-2 was the first biologic response modifier to receive approval by the U.S. Food
and Drug Administration for the treatment of advanced cancer that acted only through immune
mechanisms.
Active specific immunotherapy involves immunization to boost the cancer patient's immune
response specifically against his/her own tumor. This approach relies on the presence of tumorassociated antigens on the surface of the malignant cells and on the ability of these antigens to
produce a host immune response.
Development of tumor vaccines is an area of concentrated
research effort at the present time.
Passive lmmunotherapy
In cancer treatment, passive immunotherapy refers to the administration of specific antibodies or
activated immune cells directed toward a patient's tumor. This is an area of intense research effort,
and the therapeutic approaches described below represent investigational procedures at cancer
research centers rather than standard cancer care.
The recognition of specific tumor antigens and the development
of monoclonal antibodies
(MOABs) with relatively unique specificity for these antigens have fostered new approaches to cancer
diagnosis and therapy. As with antibody-mediated
cytotoxicity described above, unmodified MOABs
can kill tumor cells through activation of complement or through antibody-dependent
cellular
cytotoxicity. Tumor responses to unmodified MOABs have been observed in the treatment of B-cell
lymphoma and in T-cell leukemia or lymphoma.
Monoclonal antibodies can also be conjugated with nonimmune cytotoxic substances to enhance
antitumor effects. Examples of these conjugates include chemotherapeutic
drugs (e.g., adriamycin),
toxins (e.g., ricin), and radionuclides (e.g., 131I, lllln, 90y).
Adoptive immunotherapy refers to the administration of cells with antitumor activity to the cancer
patient. This approach uses either LAK cells or TILs in combination with IL-2 to confer enhanced
cell-mediated tumor lysis. In a variety of tumors, the response rate to LAK cells with IL-2 has been
relatively low: best objective response rates of 15-30 percent have been observed for melanoma and
renal cell cancer. Pilot studies of therapy with TILS and IL-2 in patients with advanced cancer are
currently in progress.
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References
1. DeVita VT Jr, Hellman S, Rosenberg SA (eds). Cancer:
Edition. Philadelphia, J. B. Lippincott Company, 1993.
Cancer Chemotherapy
Adoptive immunotherapy
of cancer:
Biotherapy 5:119-129, 1992.
SA (eds).
Biological response
modifiers
59
response
4th
in breast cancer.
Philadelphia,
W.B.
Philadelphia,
Comprehensive
J. B.
Therapy
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Manuals
Generic
Name
Short
ADA Transduced
Altogeneic
Anticea,
BaBes
T-celt
+liSt
Lymphocytes
Iio.
635]86
373364
Attogeneic
therapy,
Attogeneic
bone
marrou transplantation,
Bone marrow
therapy,
Killed
tumor celts
1-131
AsDaraginase
(Escherichia
Trade Names
Autotogous
cells
Anti-Thymocyte
synmym and
Brand or
Ant|ferritin
antibody
Globulin
coli)
Asparaginase
(Erwinia
carotovora)
Asparaginase-PEG
L-ASP, ASP,
ASPA, L-ASE
&snase, L-Asparaginase,
L-Asparagine
amidohydrolase,
Colaspase,
Crasnitin#,
EC 3.1.5.1,
Etspar,
Leunase (enzyme)
109229
L-ASP
L-Asparaginase,
(enzyme)
106977
Porton
asparaginase
(K-H)
644954
Asparaginase-PEG
(Herck)
624239
Autotogous
Autot Tumor-Trnsdcd/Gene
for IL-2 (GTI),
&utol Tumor-Trnsdcd/Gene
for TNF (Cetus),
Autot Tumor-Trnsdcd/Gene
for TNF (GTI),
Autot Tumor-Trnsdcd/Gene
for TNF-COHPA
(Cetus),
Autotogous Tumor Celt
(BCG) +
IL-2 (Bionetics),
Autologous
Tumor Celt (BCG + 1L-2 (Cetus),
Autotogous Tumor Celt Vaccine +
IL-2
(Cetus)
373364
Autotogous
(Sionetics)
Azimexon
ANX
Tumor Celt
Vaccine
37'3364
+ BCG
624335
2-aziridinecarboxamide
(synthetic
chemical,
compound
i_Lator)
BAC!
Bovine
BeG
Bacillus
Calmette-Guerin
(Bacterial
and Fungi, Nycobacteria
biological)
(Nycobacterium
bovis)
(imnu-Kxnodutator)
BCG (Cont'd)
624355
antt-Cryptosporidium
lmmunogtobutin
Connaught
614389
Pasteur
6116328
Tice
614388
TheraCys
BCG
HER
Nethanol
(Bacteria
biological)
extracted
residual
of
& Fungi Nycobacterial
Bestatin
BST
(Bacteria
biological)
61
BCG
143769
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BIOLOGICAL RESPONSEMODIFIERS
symnvmand
Generic
Name
Short
Naoes
Brand
or Trade Names
Beta-Carotene
Sotatene
Biostim
RU 41740
Bromoc rypt i ne
Bromoergoc rypt i ne
C-parvum
C.p.0
CPAR
(uttraviotet
screen)
197213
Corynebacterium
parvum,
Wettcome CN6134 (BW)
(Bacteria
& Fungi biotogicat)
220537
Corynebacteriumgranutosum
(Bacteria
& Fungi biotogical)
CGP 19835A
MTP-PE
Copovithane
CPV
Cyctosporine
Cyctosporir_,
27-400
Danazo[
Chronogyn#o Danocrine
Dehydroemetine
Detox
Dimethyl
sulfoxide
DMSO
000763
Epogen,
Procrit
628281
Dimethytbusulfan
Dinitrochlorobenzene
Dinitrofluorobenzene
DNFB
Erythropoietin
EPO
Ethytchtorformate
FiLgrastim
Freund's
Gallium
adjuvant
Nitrate
Gangtioside
Neupogen,
r-met
FCA
(Bacteria
biotogicat)
& Fungi,
GAN
Galtium
trinitrate,
GM2
HLTV antibody
4'-Hydroperoxycyc[ophosphamide
62
Hu G-CSF
Mycobacteria
Ganite
015200
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BIOLOGICAL RESPONSERQDIFIERS
sv_n_ and
Generic
Name
131
Short
Names
131 I
Imexon
II_Jne
Brand
or Trade
Antiferritin
antibody
1,3-Diazabicyc[o
2-one, 4-amino
RNA
Names
+HSC No.
(see Anticea)
(3.1.0.)
(synthetic
(Mammalian biological
(immunomodutator)
Hex-3-enchemical)
product)
Imuvert
Interferon
Interferon
and
inducers
IF,
IFN
Human fibroblast
Human Leukocyte
IFN_
Leukocyte
interferon
interferon
(Hetoy)
(Metoy)
Human leukocyte
interferon
(W-L)
Human Leukocyte
interferon,
Beta
Interferon
Alfa-nl
Human lymphobtastoid
Wettferon
Interferon
Atfa-r_3
Atferon
Atferon
Interferon
335044
interferon
(Metoy),
(Mochida)
(BW)
N Injection,
Leukocyte
Rec Gamma (Biogen)
Immune interferon
340855
IFN:
605606
339140
Interferon#,
Inanune
354655
609473
Interferon Aifa-2a
367982
Interferon Alfa-2b
Interferon G_-lb
600662
Interteukin-1
628282
621381
640032
Interleukin-2
IL-2, TCGF
[nter[eukin-2
Recc_d_inant
Interleukin-2
IL-2:
Rec (Cetus),
IL-2:
Rec (Shionogi),
IL-2:
Rec (Cetus)
IL-2
(CT)/HOELAK
IL-2
/Adherent
63
(DUl_nt)
A[desleukin,
S6820
+ TIL
LAK (CT)
364831
373364
ProIeukin
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Manuals
BIOLOGICAL RESPONSENODIFIERS
synony_md
Generic
Name
Short Names
+NSC Iio.
Aut TumVac/IL-2/BCG
373364
Aut TumVac/BCG/lt-2
Aut Tum Vac/II-2
frozen
IL-2
(CT)/TIL
IL-2:
/BCG, Tice
600664
(HLR)
lL-2/AutoEduLymph
interleukin-2
624335
(BiorExp)
Rec.(HLR)
IL-2/TIL
(HLR)
IL-2
Recombinant
IL-2
(HR)
IL-2
(HR)/OKT 3-LAK
lL-2
Polyethylene
IL:-2
BCG Vaccine,
600664
Glycol
(Peg lL-2)
(HR)/OKT 3-LAK
625376
600664
618843
IL-2
Natural
(Collaborative)
600663
IL-2
+ IL-4
(Cetus
& Sterling)
373364
lL-2
+ lL-4
(Cetus
& Sterling)
620211
IL-2
+ IL-4
HLR/STRLNG
60066/,
[iposome
IL-3 + GN-CSF
Interteukin-3
II-3 + _-CSF
Interleukin-4
643496
(Sa_oz)
641115
Eastman Kodak
620611
620211
IL-4
(K)/IL-2
(CT)
620211
373364
IL-4
(K)/IL-2
(HR)
interleukin-6
(Sandoz)
620211
6O0664
643497
ll_anol
4-lp<xneanol
349438
IVIG
LAK celts
G_guard
lymphokine
Lentinan
(Bacteria
& Fungi Lintinus
Edodes
biological)
(immunomodutator)
Levamisote
Meg-CSF
HCI*
LEV
(Immune globulin)
activated
killer
celts
Citarin
L, Decaris,
Ergamiso[,
Ketrax,
177023
Levowsol
HCL, R-12,564,
Riperco[
L,
L-Tetramisote
HCf, Tetramizote,
Tramisot,
Tramisole
(Synthetic
chemical,
immunomodu[ator)
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Manuals
syr_r_q_ and
Generic
Name
Methionyt
Short
Names
Brand
or Trade
Names
+NSC No.
Interferon-Consensus
Monoctonat
Antibody
MoAB
MVE-2
Mateic anhydride
divinyL
copotymer (immuno_lator)
N2 Transduced
N2 Retroviral
Nocardia
TIL
rubra
Octreotide
N-CWS
Acetate
Cell watt
biological)
Transduced
Vector
with
(Reduces
332586
Auto l ogous
Neo(R)
skeleton
(Bacteria
(immunomodulator)
Sandostatin
0K-432
ether
_
Gene Insert
635386
622283
& Fungi
secretory
diarrhea)
Beta hemolytic
Streptococci
(Bacteria
& Fungi Streptococcus
biological)
Ovine
SiatonmJcin
(irra_nomodutator)
PegasparQase
(Enzon)
PEG-IL-2
(CT)
625376
C[ 825, CL-67310465,
Co-Vidarabine,
Deoxycoformycin,
2'-Deoxycoformycin,
Ni_nt
218321
Pentostatin
DCF, 2'-DCF
Poly AU
Polyad_ylic-potyuridylic
Poly A-poly U
5'-Inosinic acid
polymers
Poly I:t
acid,
120949
acid
Potyinosinic-Polycytidytic
acid
stabilized
with Poty-L-tysine
and
carboxymethytcettutose
(]nterferons
and Interferon
inducers)
Poty
Ampligen
I:
Protein
Poty
C12U
A Staphylococcus
Aureus
Cowan 1
Pseudomonas aeruginosa
Heptavalent
(Bacterial
PSK
(Bacteria
Pyran
copotymer
1Drugs previously
lipopolysaccharide
& Fungi biological)
& Fungi
Oivema, Pyran,
XA 146-85-2
knoun as irmcmotherapy
301463
drugs
65
biological)
Pyran XA 124-177,
considered
biological
046015
response
modifiers.
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BIOLOGICAL RESPONSENODIFIERS
Generic
Name
Short
Names
synon_ and
Brand
Recombinant
SoLubLe CP4
reD4
Recombinant
Soluble
sT4
Recombinant
Tumor Necrosis
T4
Factor
Sargramostim
or Trade
rTNF (produced
Iiames
+NSC Iio.
by recoebination)
Thymosin
Alpha
Thymosin
Fx5
3377'93
Human thymosin-fraction
Human thymosin-fraction
(Mammalian biological
(Thymosins)
Titorone
Alpha
product)
(Synthetic
Chemical)
(ImmunomoduLator and Interferon
TIL/TNF
337793
inducer
Retrovirat
vector carrying
gene coding
tumor necrosis
factor
(PA 317/LTNFSN)
(Cetus)
TIL transduced
IL-2 (NHLBI)
TIL (GTI)
Tumor necrosis
factor
TNF
with
65228
622283
622283
TIL transduced
(Cetus/Sterting)
373364
TIL transduced/Gene
coding
for
TNF (Cetus)
636228
TIL transduced/Gene
coding
for
TNF
373364
with
Anti-CD3
activated
ty_phocytes
618843
Tumor infiltrating
lylaphocytes transduced
with the tumor necrosis
factor
gene
(Retrovirus
vector TNF-NeoR-GTI)
637656
373364
(Cetus)
(Genentech)
(Knoll)
606515
604175
635257
TP OKT 3 L1_nphoctyes
618843
for
NEOR Germ
Tumor Primed
TNF Transd
350391
VCN
Activated
[/nnphocytes
Malignant
biological
cell antigens,
product
66
618843
Manlnalian
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Section 5
HORMONES
MECHANISMS
Hormones are substances produced by the body which help regulate body mechanisms such as
growth, metabolism, and reproduction.
Used in the treatment of cancer, administration of hormones,
withdrawal of hormones, or interference with hormone function may alter the growth of hormoneresponsive malignant neoplasms. Cancer therapy which achieves its anti-tumor effect through changes
in hormonal balance is often called endocrine therapy. This includes the administration of hormones,
agents acting via hormonal mechanisms, antihormones, steroids, and surgery or radiotherapy directed
at hormone-producing
tissue.
Cancers in which endocrine therapy causes tumor regression are often referred to as hormoneresponsive.
In general, hormone-responsive
cancers derive from tissue which require hormones for
normal development
(e.g., breast and prostate cancers).
However, some cases of other cancers,
particularly melanoma and hypernephroma,
may also respond to endocrine therapy.
In recent years, laboratory methods have been developed to identify the presence of specific
hormone receptors on the surface of normal and malignant cells. The presence of hormone receptors
(particularly of estrogen and progesterone receptors in breast cancer) may predict the response of
the patient's tumor to endocrine therapy. A positive response to endocrine therapy observed in some
cases of receptor-negative
tumors suggests that hormonal agents may exert their effects through other
pathways in addition to direct action on hormone receptors of cancer cells.
Hormones
Synthetic hormones
far above the natural
modify the growth of
progestins, androgens,
Administration of estrogen, usually the oral estrogen diethylstilbestrol, has been a standard therapy
for advanced prostate cancer since the 1940's. In men, pharmacologic doses of estrogen suppress
luteinizing hormone (LH) release by the pituitary gland and result in decreased
testosterone
production (see below). This "androgen withdrawal" effect produces a clinical response in most
patients with previously untreated disease that is comparable to the therapeutic effect associated with
orchiectomy.
Hormone manipulation can provide effective control of breast cancer for many women with slowgrowing metastatic disease, particularly in soft tissue or skeleton. Hormone receptor levels in breast
cancer tissue are useful predictors of response in breast cancer patients: up to 75% of women with
tumors positive for both estrogen receptors and progesterone
receptors will respond to endocrine
therapy.
Common approaches to hormone therapy for breast cancer comprise the oral administration of
pharmacologic doses of an estrogen, progestin, or androgen as a single agent. Patients who have a
good initial response to additive hormone therapy but develop disease progression on treatment may
experience a second response when the initial agent is discontinued.
Breast cancer patients with a
69
Table of Contents
Manuals
good response to initial hormone therapy often respond to a second or subsequent hormonal
approach and may achieve long-term disease control by continuing through a series of hormonal
treatments.
Corticosteroids are hormones produced by the adrenal gland which have actions in metabolism and
immune modulation. These agents have antitumor activity in lymphomas and in lymphoid leukemias
and are included in most treatment regimens for these diseases. Corticosteroids may be used for
hormone replacement following adrenalectomy
(see below) and in the management of clinical
complications
associated with malignancy (e.g., hypercalcemia,
brain metastases).
Steroids
(particularly decadron) are often used as antiemetics prior to chemotherapy and may be used in the
supportive care of patients with advanced disease to palliate the symptoms of general debility.
Factors
Hormone-Synthesis
Inhibitors
One approach to hormone regulation is to block the production of the hormone by inhibiting the
actions of enzymes which participate in its synthesis. Most estrogen in postmenopausal women is
produced outside the ovary by enzyme actions on steroid substances made by the adrenal gland. The
drug aminoglutethimide blocks the action of several enzymes in this pathway, resulting in decreased
production of adrenal steroids ("medical adrenalectomy"), especially the androstenedione
which is
converted to estrogen.
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Table of Contents
Manuals
Aminoglutethimide
has been used in the management of hormone-responsive
breast cancer,
usually after relapse during other endocrine therapies.
Because the drug interferes with the
production of glucocorticoids and mineraloeorticoids
necessary for normal metabolism and body
function, patients who receive aminoglutethimide
must also take steroid replacements on a daily basis
to avoid developing adrenocorticoid
insufficiency (Addison's disease) and orthostasis (see below).
Antihormones
The identification of specific hormone receptors on cancer cell surfaces offered new approaches
to regulate the actions of hormones in promoting growth of hormonally-responsive
tumors. Since the
early 1970's, "antihormone" agents have been developed that interfere with the interaction between
the hormone molecule and its receptor site that stimulates cell growth and proliferation.
Tamoxifen (Novaldex), the first antiestrogen
to achieve widespread clinical use, has become
standard first-line hormonal therapy for metastatic breast cancer and for adjuvant therapy of early
stage breast cancer in postmenopausal women.
Clinical trials are currently underway to test the
efficacy of tamoxifen as therapy of ductal carcinoma-in situ (DCIS) and as a chemopreventive
agent
in women at high risk of breast cancer.
Tamoxifen acts by attaching to the cell surface estrogen receptor without initiating the intracellular
processes which lead to proliferation.
Its presence at the receptor site blocks the attachment of
natural estrogens and thus interferes with their actions on breast cells and breast cancer cells.
Tamoxifen also stimulates the production of growth factors that further modulate the proliferation
of breast tissue.
While tamoxifen has antiestrogen actions on breast tissue, it has estrogen-like activities at other
organ sites. Women receiving tamoxifen as adjuvant therapy have benefits similar to those of
estrogen replacement
therapy in lowering blood lipids and slowing bone loss. However, they also
have potential side effects associated with estrogen therapy such as endometrial
abnormalities and
risk of thromboembolism.
Other antiestrogens
are currently under development
that have pure
antiestrogen
effects (e.g., toremifene) or that may be used in tumors that have become resistant to
tamoxifen.
The recent development of antiandrogens has expanded the options for medical management of
advanced prostate cancer. The drug flutamide attaches to androgen receptor of prostate cancer cells
and blocks the actions of testosterone and dihydrotestosterone
in stimulating cell growth. Flutamide
may be used as a single agent for initial hormonal treatment of advanced disease, or it may be given
with an LHRH agonist (or surgical orchiectomy) as "combined androgen blockade."
Casodex and
nilutamide, other antiandrogens, are currently in preclinical and early clinical studies.
Surgery and Radiotherapy
to Hormone-Producing
Tissues
Surgical procedures
to remove hormone-producing
tissues were among the first attempts at
endocrine therapy of cancer (e.g., oophorectomy
or adrenalectomy for breast cancer, orehiectomy for
prostate cancer).
Radiotherapy
to hormone-producing
organs (e.g., ovaries) has been used to
suppress hormone production in patients who could not withstand surgery.
The use of drugs to suppress hormone production has, to a great extent, replaced surgical
approaches to endocrine therapy of breast cancer:
LHRH agonists for "medical castration", and
aminoglutethimide
for "medical adrenalectomy."
However, orchiectomy remains a standard approach
71
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Manuals
to endocrine management because of the simplicity of the procedure, its immediate effect, and the
lack of side effects associated with drugs used for endocrine therapy of this disease.
Hormone Replacement
Tumor involvement or specific cancer-directed therapy may destroy tissue that produces hormones
necessary for normal metabolism and body function.
In these clinical situations, hormone
replacement therapy is necessary to maintain life. For example, patients receiving aminoglutethimide
for breast cancer have suppressed production ofglucocorticoids and mineralocorticoids which function
in glucose metabolism and fluid and electrolyte balance, in addition to the desired suppression of
androstenedione
production.
Thus patients receiving aminoglutethimide
must also take a
glucocorticoid (hydrocortisone)
and may also require a mineralocorticoid (Florinef) to replace the
natural corticoids normally produced by the adrenal gland. In contrast to endocrine treatment of
cancer, hormones administered as replacements are given in physiologic doses rather than at the
higher, pharmacologic doses used for tumor-directed therapy.
Thyroid hormone
stimulating hormone
therapy.
72
Table of Contents
Manuals
Sy.o_m =d
Generic
Name
Short
Adrenocorticotropic
hormone
Algestone*
Names
ACTH
Acetophenide
Brand
or Trade
025933
Deladroxone#,
(progestin)
067831
RS-2208
Amcinonide
CL-34699,
Anagestone
AG, AGT
Acetate
Bectomethasone
Dipropionate*
+NSC No.
Acethropan,
Acthar,
Adrenal
Cortex
hormone, Adrenocorticotrophin,
Adrenocorticotropin,
Corstiline,
Corticotrophin,
Corticotropin*,
Cortrophir_,
Depo-ACTH#
Amadinone Acetate
Aminoglutethimide*
Names
Droxone#,
SQ 15,101
(progestin)
Cyclocort
(glucocorticoid)
Ba-16038,
Cytadren,
Elipten
(adrenocorticat
suppressant)
330915
Anatropin#
073880
(progestin)
Beclometasone,
Beclovent,
Beconase,
Sch-18020W, Vancenase, Vanceril
(gtucocorticoid)
Benorterone#
SK&F-7690
(anti-androgen)
Benzestrot
Estrogen
408889
Betamethasone*
Cetestone,
Sch-4831
(gtucocorticoid)
039470
Betamethasone
Acetate
Concx_nent of Cetestone
(gtucocorticoid)
Betamethasone
Benzoate*
Benisone#,
Betamethasone
Dipropionate*
Continent
of Atphatrex,
Diprotene,
Diprosone,
Component of Lotrisone,
Psorion,
Sch 11460
(gtucocorticoid)
206525
Betamethasone
Phosphate*
Sodium
090616
Betamethasone
Valerate*
Conq>onent of Betatrex,
(glucocorticoid)
Uticort,
Botasterone#
Myagen#,
U-19763
Busretin
Hoe 766,
Suprafact
Acetate
Calusterone
Carbenoxotone
CAL, CLS
Sodium
W-5975
(gtucocorticoid)
Sotuspan
Beta-Vat,
Valisone
(anabolic)
Dimethyttestosterone,
U-22,550 (androgen)
Methosarb#,
(Biorex, England)
Casodex
Chtormad_none*
Acetate
Sotuspan
206540
066233
088536
281727
Anti-androgen
CAP
Bovisynchron, Chlormadinonu
(Potish), Clordion, Gestafortin,
Lormin, Lutinyt, Matrot, Synchrosyn,
Synchrosyn P (progestin)
73
092338
Table of Contents
Manuals
NECHAMISMS
synonv____
Generic
Name
Short
Names
Chlorotrianisene*
Chromic Phosphate
P 32
+NSC No.
Anisene, Chtorotrianisine,
Chtorotris,
Chtortrianizen,
Ctorestrolo,
Ctorotrisin,
Hormonisene, Khtortrianizen, Merbentut,
Metace,
Rianit,
TACE (estrogen)
010108
Chromphosphotope#,
CinQestot*
Phosphocot
P 32
Progestin
Ctocortotone
Acetate
SH 818 (gtucocorticoid)
Ctocortotone
Pivatate*
Clocortotone
trimethyt
SH 863 (glucocorticoid)
CloQestone*
Acetate
Ctomegestone*
AY-11,440
Acetate
(progestin)
SH 741 (progestin)
Ctometherone#
Ctomiphene*
acetate,
38000 (anti-estrogen)
Citrate)
Cis-Ctomiphene
citrate,
Ctomiphene A
citrate,
Serophene, Zuclomiphene citrate
151466
035770
Corticotropin*
See Adrenocorticotropic
Cortisone
Cortisone,
Cortogen acetate#,
Cortone acetate,
Component of
Neosone (gLucocorticoid)
009703
Cortivazot#
Gtucocorticoid
080998
Cosyntropin*
Cortros,/n
Cyproterone
Acetate*
Acetate
hormone
(adrenocorticotropic
hormone)
SH 714 (anti-androgen)
Decapeptyt
D-TrP6
Detrnadinone Acetate
R$-1301 (progestin,
anti-estrogen)
Descinotone
Ct-27,071
Acetonide#
081430
(LH-RH)
anti-androgen,
(glucocorticoid)
044827
009567
Desoxycorticosterone Acetate
DCA, DOCA,
DOXO
Cortate acetate,
Decortin,
Decosterone, Decostrate#,
Doca acetate#,
Dorcostrimle,
Percorten
acetate#,
Percotot,
Prirnocort,
Primocortan,
Syncort (adrenocortical
steroid)
Desoxycorticosterone
Pivatate*
Percorten
Dexamethasone*V
Dexamethasone
Acetate*
DXM
of themtignanciesmontioned
cancers, consider ancillary
pivatate#
(adrenocorticat
in the introductiononp.
unless specifically
stated
74
steroid)
095278
345211
37 (botd),
code ashormonat
to be hormonal therapy.
Table of Contents
Manuals
S,,,nony_
and
Generic
Name
Short
tim
Brand or Trade
Names
Dexamethasone
Dipropionate
ST 12
Dexamethasone
Sodium Phosphate*
Datalone,
Hexadrol,
(gtucocorticoid)
+NSC go.
Con_onent
of NeoOecadron
Dienestrot*
DV
Component of Estan#,
(estrogen)
Diethylstitbestrot*
NCO
DEB, DES,
Bio-Des,
Comestrot,
Cyren A,
Di-Estry[,
Domestrot,
Estitbin,
Estrobene,
Etrosyn,
Fonatot,
Grafestrot,
Hi-Bestro[,
Nicroest,
Nilestrot,
Oestrogenine,
Serrat,
Sexocretin,
Sibot,
Stit-Rot,
Stitbestrot,
Stitbetin#,
Stitboestroform,
StiLkap,
Synthoestrin,
Syntofotin,
trans-Diethytstitbestrot,
Vagestrot#
(estrogen)
003070
Fosfestrot,
(estrogen)
010481
propionate,
Masteril,
propionate,
012198
Dydrogesterone*
Diphaston,
Dufaston,
Duphaston,
Duvaron, Gestatron,
Hydrogesterone,
lsopregnenone,
Prodel,
Retrone,
Terotut
(progestin)
092336
Equitin
7-Dehydroestrone
010971
Estradiot*
009895
009566
Diethytstitbestrot
Di_:>hosphate*
Diethytstilbestrot
Dipropionate
Diftucortolone*
Diftucortolone*
Dibestit#
Synestrot#
Stitphostrot
(estrogen)
Glucocorticoid
Pivatate
Dromostanolone
Propionate
NDNT
SH-968
(glucocorticoid)
Drotban#,
Drostanotone
Emdisterone,
Masterid,
Masterone,
Nedrotestron
Permastrit,
32379
(estrogen)
Estradiot
Benzoate
Progynon
Estradiot
Cypionate*
DepGynogen, Depo-Estradiol,
Coe_onent of Depo-TestadioL
Estradiol
059809
Dipropionate
Ovocyclin
B (estrogen)
dipropionate#
(estrogen)
(estrogen)
003354
112259
Estradiot Mustard
Estradiot Vaterate*
017590
EstranmJstine
089201
?5
Table of Contents
Manuals
sys.,onym
and
Generic
Name
Short
Estramustine
Phosphate
Nm
Sodium*
Estriot
+NSC No.
Emcyt, Estracyt,
Estramustine
phosphate disodium,
Ro 21-8817/001
(chemotoxic hormone)
089199
Theetot#
012169
(estrogen)
Estrogens.
ConjucJated*
Component of Cyctogesterin#,
Component
of Nitprem e component of PNB-200,
Component of PNB-400, Component of Premarin
with Nethyttestosterone,
Premarin
Estrogens,
Esterified*
Amnestrogen#, Estratab,
Component of
Estratest,
Nenest, Component of Nenrium
(l_attiative)
Estrone*
Theetin
Estropipate*
Ethinyt
Component of Brevicon,
Chee-O-Gen,
Chee-O-Genf,
Component of Demutan,
Diogyn Ee Dytoform,
Esteed, Estigyn_
Estinyt,
Eston-E, Estorat,
Ethidot,
Ethinorat#_
Eticyctin_
Eticylol#_
Etinestrot,
Feminone, Ginestrenee
Hatodrin,
%nestra,
Component of Levten, Component
of Loestrin,
Component of Lo/Ovral,
Component of Lynorat#,
Nenotyn, Microfottin,
Coqx)nent of Modicon, Component of Nordette,
Component of Norethrin
1/35E, Component of
Nortestrin,
Novestrote
Oradiot,
Orestratyn,
Patonyt Perovex, Spanestrin
(estrogen)
Estradiol*
Ftudrocortisone
Acetate
(estrogen)
Ftorinef
Acetate
(satt-regutating)
009699
(adrenocorticoid
010773
steroid),
Ftumethasone*
U-10,974
Ftuoromethotone*
Cortitet,
Detmeson, Ftuoromethatone,
FNL Forte,
FNL Liquifitm,
Component
of FNL-S Liquifitm,
FNL S.O.P.,
Component of Neo-Oxylone#,
Oxytone#,
U-8614 (gtucocorticoid)
031001
Androfluorene,
Anrosteroto,
Ftuotestin,
Ftuoximesterone e Ftusteron,
Ftutestos,
Halodrin,
Halotestin,
NeoOrmonal, Oralsterone,
Oratestin,
OraTestryt#,
Testorat,
Uttandren
(androgen;
pattiative)
012165
Nethrat,
067756
Ftuoxymesterone*
Fluperotone
Acetate
Fluprednisotone*
Ftuprednisotone*
(gtucocorticoid)
P-1742
Atphadrot#,
Vaterate#
054702
(gtucocorticoid)
U-7800
(glucocorticoid)
047439
Gtucocorticoid
Fturandrenotide*
Cordran,
Flurandrenotone#,
(gluc_orticoid)
Fturogestone Acetate
SC-9_0
(progestin)
76
33379
_5411
Table of Contents
Manuals
syr_vas and
Generic
Name
Short
Names
6rand
or Trade
Names
Ftutamide*
Eutexin,
Formocortai
DefLamene,
Gestactone
SH-1040
Gosrelin
Decapeptide
1,
(LHRH agonist)
Gestonorone
Caproate
SH-582
Niftholide,
+IISC ilo.
Niftotide,
Sch 13521
Ftuderrna (gtucocorticoid)
1478._
150527
(progestin)
[C!
118,630,
Zoladex
(progestin)
084054
HaloDrogesterone
Progestin
Hexestrol
Cycloestrol,
Estrifar,
Estronat,
Extra-Plex,
Hexanoestrotm
Hexestrofen, Hexoestro(,
HormoestroL,
Sinestrot,
Synestrot,
Synoestrot,
Synthovo, Syntrogene
009894
Acticort,
Aeroseb-NC, Cetacort,
Cort-Dome,
Cotter,
Cortenema,
Cortril,
(gLucocorticoid)
010483
000741
Hydrocortisone*
HC
Hydrocortisone
Acetate*
Cortef
acetate,
(glucocorticoid)
Hydrocortisone
SodiumPhosphate*
Hydcocortone
Hydrocortisone
Sodium Succinate*
Hydroxyprogesterone
HDC
Caproate*
Ketoconazote*
Leuprotide
Levothyroxine
Liothyronine
(9tucocorticoid)
Detatutin#,
Component of Detutevat
Gestorat
LA 250, Prodrox (progestin)
Abbott
(TAP),
Sodium
Phosl_ate
acetate-AS
A-hydroCort,
Solu-Cortef
(glucocorticoid)
Nizoral,
Acetate*
Cortrit
Depot
377526
Levothroid,
Synthroid
(thyroid
hormone)
Sodium*
Basoprocin,
Tertroxin,
Cynomel, Cytomet,
(thyroid
hormone)
Euthroid,
Lynestrenot#
Ethynytestrenol,
Extuton,
Org 485-50,
Orgarnetrit#,
Ovoresta H (progestin)
MedroQestone
AY-62022
Hedrysone*
017592
R-41,400
Liotrix
Medroxypro9esterone
Acetate*
2X#,
DMPA, MAP,
MPA
Thyrotar
(thyroid
lbiothyron,
080774
hormone)
Linestrenot,
Orgametrot,
(progestin)
037725
123018
Curretab,
Cycrin,
Depo-Provera,
Fartutin,
Gestapuran,
Lutopolar,
Lutorat,
Oragest,
Pertutex,
Prodasone,
Progestat,
Provera,
Proverone,
Repromap, Repromix,
Sirprogen,
U-8839, Veramix (progestin)
026386
Redrocort#,
063278
77
U-8471
(glucocorticoid)
Table of Contents
Manuals
_and
Generic
Name
Megestrot
Short
Names
Acetate*
Metengestro[
Acetate
MGA
+NSC N._
9.
071423
BDH-1921, 5373
(antineoptastic
070968
progestin)
Meprednisone*
Betapar#,
Sch-4358
527579
Mesterotone
SH-TE3 (androgen)
075054
Mestranol*
C_ent
of Enovid, C_ent
of
Norethin 1/50 M, Component of Norinyl,
Component of Nor_n,
Component of
Ortho-No_m_j Component of Ovuten
(estrogen)
Methandrostenolone
HA
Methytprednisotone*
Abirot,
Anabol in, Compound 17309, Crein,
Danabo[, Dehydromethyttestosterone,
Dianabot#,
Geabol, Metanabol,
Metandienon,
Metandrostenotone,
Metaso[,
Methandronotone,
Naposim, Nerobo[,
Protobotin,
Stenoton (androgen)
042722
019987
Medrone,
Nethytprednisotone
Acetate*
DepMedatone, Depo-Medrol,
Component of Neo-Medro[ (gtucocorticoid)
048985
Methytprednisolone
Phosphate
Sodium
Nedrot Stabisot#,
(glucocorticoid)
048989
Methytprednisotone
Succinate*
Sodium
A-methaPred,
Sotu-Medrot
(glucocorticoid)
U-12,019E
Methyltestosterone*
Andrometh,
Androsan, Androsten,
Anertan,
Dumogran, Component of Estratest,
Homandren, Malestrone,
Metandren,
Netrone,
Meo-Hombreol-M#,
Oreton
Methyl,
Component of Premarin uith Methyltestosterone,
Sterony[,
Synandrets,
Synandrotabs,
Testoviron,
Testred
(ICN)
(androgen)
Methynodio[
SC-19198
Diacetate#
Miboterone
Miboteron,
(anabotic;
Mifepristone
RU 486
Nafarelin
Acetate
Nafoxidine
HCL
Nandrotone
Decanoate*
(progestin)
U-10,997
androgen)
RS-94991-298,
NAFO, NFX
009701
$ynaret
072260
(LHRH agonist)
U-11100A
(anti-estrogen)
Deca-Durabolin,
(androgen)
78
070735
Nandrobotic
L.A.#
Table of Contents
Manuals
Sy_n_
Generic
Name
Short
Nandrotone
Phenpropionate*
liars
NPPo NTPP
Nitutamide
Brand
and
or Trade
Names
+MSC No.
Ourabolin,
Fenobotin,
Nandrobotic,
Nandrotone phenytpropionate,
Nerobit,
Nortestosterone
phenytpropionate,
Phenobotin,
Superanaboton
(androgen)
023162
Anti-androgen
4-Nitroestrone
Nitrmifene
321803
Citrate
Anti-estrogen
110407
Nivazot
Win-27,914
Norethandrotone
Androgen
009893
070581
Nytestriol
49825
101105
Oxandrotone*
Anavar,
Protivar,
Vasorome, 8075 C.
Oxymethotone*
HMD
Potyestradio[
Pitocin,
Acetate
SC 11585,
B. (androgen)
Syntocinon
Estradurin0
(estrogen)
PRDL
Acetate*V
Leo 114
component of Ataraxoid,
Detta-Cortef,
Hydeltra,
Component of K Predne-Dome#,
Meti-Derm,
Paracortot#,
Predne-Dome#,
Sterane
(gtucocorticoid)
009120
DepPredatone,
Meticortetone
Predate,
Sterane IM and IA
010966
acetate,
Meticortetone
Soluble,
Prednisotone
sodium succinate,
Sotu-Decortin
(gl_ocorticoid)
Predniso[one
Sodium Phosphate*V
Hydettraso[, Infl_se,
Metreton,
Component of Opti_d,
Pediaprod,
Predate-S,
PSP-IV, Sotu-Predalone,
Con_:x_nent of Vasocidin
Solution
(gtucocorticoid)
Prednisotone
Tebutate*V
Hydeltra-T.B.A.,
(g[ucocorticoid)
PDN, PRD,
PRED
Prednivat*#
V
026198
(Tumor marker)
Prednisotone
Sodium
HemisuccinateV
Prednisone*V
067068
Hatdrone,
Stemex
(glucocorticoid)
Phosphate*
Prednisotone*V
Prednisotone
(estrogen)
Adroyd#, Anadrol,
C1-406,
Drostano[one,
Medrotestron,
Metholone,
Ora-Testryl
(anabolic
androgen)
Oxytocin
Paramethasone*
(glucocorticoid)
Ancortone,
Dettasone,
Paracort#,
W-4869
Predalone
009151
T.B.A.
Dacortin,
Delta-Dome#,
Dettra,
Meticorten,
Orasone,
Uttracorten
(gtucocorticoid)
010023
(gtucocorticoid)
of the ma[ignanciesmentia-,_,
cancers,
consider anciLLary
in the introdluctiononp.
untess specificatty
stated
79
37 (botd),
ode ashormonat
to behecmonat
theral_f.
Table of Contents
Manuals
Generic
Name
Pregnenotone*
Short
Names
Succinate
+NSC No.
sterot
Pro9esterone*
Component of Cyctogesterin_,
Gesterot
Lipo-Lutin#,
Nalutron#,
Syngesterone,
Syngestrets
(progestin)
Quinestrol
Estrovis,
Ouin9estanot*
Acetate
50,
00970/,
W-3566 (estrogen)
W-4540 (progestin)
Ouingestrone#
W-3399 (progestin)
Sitandrone*#
SC-16148
Somatostatin
Growth
Somatrem
Protropin (rHGH,
(androgen)
095147
hormone retease
inhibiting
factor
growth hormone)
Somatutine
Spironotactone
component of Aldactazide,
Aldactone,
SC-9420, Spiresis,
Spiridon,
Spirotactone,
Spirone,
Uractone,
Verospirone
(diuretic;
aldosterone
antagonist)
150399
Stanolone
Neodrot
010972
Stanozotol*
WIN 14833,
Tamoxifen
SPL
Citrate*
Testotactone*
Winstrol
(androgen)
TAM, TMX
lcl-46,474,
Nolvadex,
(anti-estrogen)
TL
023759
009700
Testosterone
Tamofen,
043193
Tamoxifen
180973
Testosterone
Cypionate
Con_>onent of Oepo-Testadiol,
OepAndro
100, DepAndro 200, Depo-Testosterone,
Depovirin#
(androgen)
009157
Testosterone
Enanthate
017591
Testosterone
Ketotaurate
Androgen
Testosterone
Phenytacetate#
Androgen
Testosterone
Propionate
Thyrogtobutin*
TP
Synandrot,
(androgen),
Protoid,
(thyroid
Synerone#
Thyractin#,
hormone)
80
009166
Thyroprotein#
Table of Contents
Manuals
Generic
Name
Short
Thyroid
Names
sw_n_s and
Brand
or Trade Names
+MS(: No.
026492
Thyrotropin
Tigestol*
Progestin
Toremifene
Citrate
FC 1157a
Tratonide#
(anti-estrogen)
Gtucocorticoid
Trestotone
Acetate#
U-15,614
Triarncino[one*
Triamcinolone
(antineoptastic;
androgen)
Aristocort,
Kenacort
(gtucocorticoid)
Acetonide*
013397
Azmacort,
Flutone#,
Kenatog,
ConM_onent
of Mycotog II,
Con_onent of Myco-Triacet
Con_onent of Mytrex,
TAC-3, TAC-40#,
Tramacin#,
Triacet,
Triamonide
40,
Trymex# (gtucocorticoid)
Triamcinotone Acetonide
Sodium Phosphate
CL-61965, CL-I06359
(gtucocorticoid)
Triamcinolone
Aristocort,
Aristocort
forte
parenterat,
Kenacort Diacetate
syrup, TAG-D#, Triamotone 40
(gtucocorticoid)
Diacetate*
Triamcinolone
Hexacetonide*
TATBA
Trilostane*
Trioxifene
069948
021916
11,
Aristospan,
CL-34433
(gtucocorticoid)
Modrenal,
Win 24,540
(adrenocortical
suppressant)
Mesytate
Triptoretin
Compound 133314
(anti-estrogen)
CL 118,532
Vitamin
Zotadex
(see
Chotecalciferot
Gosretin)
(functions
as a hormone)
606864
8]
Table of Contents
Manuals
82
Table of Contents
Manuals
NOTES
83
Table of Contents
Manuals
84
Table of Contents
Manuals
Section 6
DRUGS USED IN THE TREATMENT
of AIDS
Identification of the HIV retrovirus as the causative agent of AIDS and scientific studies of the
virus life cycle have opened the door to pharmacologic research in antiviral drugs with potential
efficacy against this agent. One step in the reproductive cycle of HIV involves the transfer of genetic
information from RNA to DNA, a reverse or "retro" direction from the replication process in human
ceils. This transfer of genetic code is catalyzed by the enzyme reverse transcriptase.
The first drugs
tested for activity against HIV were developed to interfere with this part of the viral replication
process, either by providing imperfect substrates for the reverse transcriptase enzyme or by inhibiting
the formation or activity of reverse transcriptase.
Nucleoside analogs are drugs whose chemical structure is similar to that of the nucleosides
(building blocks for DNA and RNA) which are incorporated into viral DNA by reverse transcriptase.
In general, the slight differences in structure from normal nucleosides interfere with formation of the
85
Table of Contents
Manuals
Opportunistic
Infections
Opportunistic infections are a major cause of morbidity among HIV-infected persons and represent
the cause of death in approximately 90 percent of AIDS patients. Patients with AIDS are at risk for
infections that are common in the general population, as well as for opportunistic infections that take
advantage of the immunosuppressive effects of HIV.
Primary Pulmonary Infections
Pneumocystis carinii pneumonia (PCP) occurs in approximately 80 percent of patients with AIDS
who are not receiving prophylaxis at some time during the course of their illness. Clinical
presentation includes fever, respiratory symptoms, and exercise intolerance.
Diagnosis depends on
demonstrating
the organism in sputum or bronchial brushings.
Two antibiotic regimens with
comparable efficacy in treatment of PCP are trimethoprim/sulfamethoxazole
(oral or intravenous
86
Table of Contents
Manuals
administration)
and pentamidine (intravenous
administration).
For patients who cannot tolerate
either of these regimens, investigational approaches of dapsone and trimethoprim or of primaquine
plus clindamycin are often used. The addition of corticosteroids
(e.g., prednisone)
to specific
antimicrobial therapy has resulted in marked decrease in respiratory failure and death in patients with
moderate or severe PCP.
Effective strategies to prevent PCP include prophylaxis with oral
trimethoprim/sulfamethoxazole
or inhaled (aerosolized) pentamidine.
Patients with AIDS may also develop respiratory symptoms from infections caused by the fungus
Coccidioides immitis.
Pulmonary findings range from focal lung disease to diffuse pulmonary
infiltrates and may be associated with skin lesions and lymph node or liver involvement.
Amphotericin B is standard treatment for coccidioidosis in AIDS patients.
Histoplasmosis is endemic in the central United States. In immunocompetent
persons, primary
infection by Histoplasma capsulatum seldom advances beyond the lungs or hilar lymph nodes.
However, patients with HIV infection frequently present with disseminated disease manifest by fever
and weight loss.
Amphotericin
B is standard,
effective treatment
for disseminated disease;
maintenance therapy may be required to prevent relapse. Disseminated histoplasmosis in a patient
seropositive for HIV is considered diagnostic of AIDS.
Patients with AIDS are at high risk for reactivation of latent tuberculosis (Mycobacterium
tuberculosis).
Early in the course of HIV disease, pulmonary tuberculosis predominates; as HIV
disease progresses, atypical presentations and disseminated tuberculosis become more common. Drug
regimens used for tuberculosis in AIDS patients include isoniazid, rifampin, pyrazinamide, and
ethambutol.
Disseminated
infections with nontubercuious
mycobacteria, particularly Mycobacterium avium
complex, are among the most commonly reported bacterial infections in AIDS patients with severe
immunocompromise.
In contrast to tuberculosis, pulmonary symptoms are infrequent; fever, weight
loss, anemia, and diarrhea are usual manifestations of infection. Antituberculous
drug regimens have
been disappointing in the treatment of M. avium complex. Prolonged therapy with combination drug
regimens is used to reduce symptoms.
Agents include ethambutol,
clofazamine, ciprofloxacin,
rifampin or rifabutin, and amikacin.
Bacterial pneumonia is also common in AIDS patients. Infections acquired in the community are
often due to Streptococcus pneumonia
or HemophUus influenza.
Infections
acquired during
hospitalization
(nosocomial
infections)
are frequently due to Gram negative bacteria or to
Staphylococcus aureus. Management includes antibiotic regimens appropriate for the sensitivities of
the infecting organism.
87
Table of Contents
Manuals
combination
with sulfadiazine; corticosteroids
may be used in patients with cerebral edema.
Alternative
therapeutic approaches are under investigation for patients who are intolerant of
pyrimethamine or sulfadiazine. These include combinations of pyrimethamine with clindamycin, highdose pyrimethamine, azithromycin, clarithromycin, dapsone, and 566C80.
Cryptococcus neoformans, a yeast-like fungus, is the major cause of meningitis in AIDS patients.
The organism usually infects the brain as well as the meninges, producing a diffuse encephalitis in
many patients. The organism or its antigen is usually detected in spinal fluid obtained by lumbar
puncture.
Initial therapy for cryptococcal meningitis in AIDS patients comprises amphotericin B
alone or in combination with flucytosine; following initial treatment, suppressive therapy with
fluconazole is given for the life of the patient.
Fungal meningitis in AIDS patients may also be
caused by Coccidioides immitis, also treated with amphotericin B.
Central nervous system infections in patients with AIDS may also be due to Mycobacterium
tuberculosis, presenting with clinical features of meningitis or localized lesions (tuberculomas).
Infections of the Gastrointestinal
Tract
Gastrointestinal
infections in patients with AIDS are a major cause of morbidity; malabsorption,
diarrhea, and wasting can be linked to infection in most patients with advanced disease.
Oropharyngeal candidiasis (thrush) and vaginal infections with Candida species are common in
immunocompromised
patients. Candidal infections of the esophagus or the respiratory tract are
recognized as indicator infections for AIDS diagnosis. These infections are seldom invasive or
disseminated unless patients are neutropenic or have other complicating factors. Oropharyngeal
candidiasis is treated by topical administration of nystatin, clotrimazole, ketoconazole, or fluconazole.
Esophageal
candidiasis usually requires ketoconazole;
amphotericin
B may be administered
intravenously to patients with candidal esophagitis that is refractory to therapy with the azole drugs.
Enteric infections with the protozoa Cryptosporidia, Microsporidia, and Isospora may cause
diarrhea, weight loss, nausea or vomiting, and abdominal pain. Therapy is predominantly supportive,
emphasizing fluid balance, electrolytes, and nutrition. No specific therapies have been shown to be
effective for cryptosporidiosis or microsporidiosis, although metronidazole may have some efficacy in
microsporidiosis. Isosporiasis is common in Haitian or African patients with AIDS: it can be treated
effectively with trimethoprim/sulfamethoxazole,
pyrimethamine, metronidazole, or quinacrine.
Bacterial infections of the gastrointestinal tract are also common in AIDS patients. Salmonella,
Campylobacter, and Shigella infections, usually self-limited in immunocompetent
individuals, often
require antibiotic therapy in patients with AIDS.
Viral Infections
Cytomegalovirus (CMV) infection is common among adult patients with AIDS. Retinitis due to
CMV is the most frequent presentation, manifest as painless progressive visual impairment in patients
with advanced disease. CMV infection at other sites may cause stomatitis, esophagitis, gastritis, and
colitis in the gastrointestinal
tract; hepatitis and cholecystitis; and adrenalitis with adrenal
insufficiency. Antiviral therapy with gancyclovir may be limited by bone marrow toxicity in AIDS
patients; foscarnet is an alternative therapy for gancyclovir-resistant
infections or in patients who
88
Table of Contents
Manuals
cannot
tolerate
gancyclovir.
Progressive infections at oral and genital sites in AIDS patients are usually due to herpes simplex
virus (HSV).
HSV is also a common cause of esophagitis in patients with advanced disease.
Acyclovir is the drug of choice in initial treatment of HSV infections as topical, oral, or intravenous
therapy. Foscarnet or vidarabine may be used in acyclovir-resistant
HSV.
Common viral infections due to varicella-zoster virus (VZV), such as chicken pox and shingles,
may be severe and progressive in immunocompromised
patients and may require treatment with
acyclovir.
Other Complications
of AIDS
Neurologic complications of AIDS are diverse, affecting both the central and peripheral nervous
system, and may occur at all stages of disease. The clinical syndrome of AIDS dementia complex is
among the most common central nervous system complications of untreated AIDS and is one of the
diagnostic criteria for AIDS. Cognitive and behavioral findings (e.g., slowing of thought processes,
impaired concentration,
apathy, personality changes) are accompanied by impaired motor function.
The clinical course of the complex is variable in progression.
Accumulating evidence suggests that
the clinical syndrome is due to effects of HIV on nervous system tissue, and therapy with
antiretroviral
agents is directed at the underlying HIV infection.
Symptomatic management may
include the use of neuroleptic drugs.
Progressive multifocal leukoencephalitis (PML) represents an opportunistic infection by the JakobCreutzfeldt (JC) virus. Focal neurologic deficits are caused by areas of demyelination, i.e., loss of the
myelin sheath covering nerve fibers. While deficits are usually progressive, the clinical course is more
protracted than that of other central nervous system opportunistic
infections.
There is no proven
therapy for PML, although approaches
including interferons
and antiviral agents are under
investigation.
Many agents used to treat AIDS and its complications have broad applications in cancer
therapy. For example, antibiotics used to treat infections in AIDS patients are frequently
used to treat similar infections in patients who are immunosuppressed
by cancer or its
treatment.
Also, many chemotherapeutic
agents and biological response modifiers used in
cancer therapy have applications in the management of HIV infection. The inclusion of a
drug in this section of Book 8 does not imply that the medication is used only for treatment of
AIDS or its complications. Check sections 1-5 first for cancer-directed
treatment.
If not found
in sections 1-5, do not code for cancer patients.
89
Table of Contents
Manuals
References
1. American Foundation for AIDS Research (AmFAR). AIDS/HIV Treatment Directory. Compiled
and published on a regular basis by AmFAR, 1993 (Updated quarterly). Available through CDC
National AIDS Clearing House (800) 458-5231.
2. Johnston MI, Hoth DE
1293, 1993.
Science 260:1286-
Therapy.
Dallas,
Treatment, and
5. Matthews SJ, Cersosimo RJ, Spivak ML. Zidovudine and other reverse transcriptase inhibitors
in the management of human immunodeficiency virus-related disease. Pharmacotherapy 11(6):419449, 1991.
9O
Table of Contents
Manuals
Sy_-Vm and
Generic
Name
Short
Names
+NSC No.
HlV Infection
A - 77003
A 80967
AL 721
Inhibits
Alt-trans-retinoic
acid
binding
See Tretinoin
tesions
Atpha-APA
derivatives
(under
in
R 18893,
of HIV to target
Atpha
Interferon
1NF
R 89439
Ant abuse
D i sutf i ram
AS-101
Arsanitic
CD8 ]nfusion
Azidothymidine
AZT
inhibitor)
of virus
from infected
Response
acid
are
the
from an HIV-infected
stimutated
to repticate
into
transcriptase
retease
CD8+ T-tymphocytes
person
outside
and then
patient
3'-Azido-3'
are
body
of origin.
Zidovudine
transcriptase)
of Kaposi's
the
reinfused
Deoxythymidine,
Retrovir,
BW A 509U,
(inhibits
(used
in
the
reverse
treatment
sarcoma)
Azidouridine
BI-RG-587
Nevirapine
(non-nucteoside
t ranscriptase
BRL 61063
Exerts
reverse
inhibitor)
TNF-atpha
(cachectin)
inhibition.
Cas t anospermi ne
CD4- I gG
CD4-PE40
Recomb. protein;
region
Rx of
(atpha-anitino-phenytacetamide)
with
Poty I: Poty
Medi f iers)
for
sarcoma
reverse
May interfere
cetts
AmpLigen
Autotogous
investigation
Kaposi's
(Non-nucteoside
cetls
consists
of CD4 tinked
Aeruginosa
exotoxin
91
of HIV-binding
to Pseudomonas
A
602670
Table of Contents
Manuals
synonym
and
Generic
M_
Short
Iim_s
Cimetidine
H]V Infection
(Cont'd)
Tagamet (immunomodutatory
interacts
Con_ndQ
Curdtan
+MSC No.
with
effect,
Hz receptors
on cells
(See GLQ223)
Sulfate
D4T
Didehydrodideoxythymidine,
(thymidine)
analogue,
(Non-nucteoside
Dideoxynucteoside
Stavudine
reverse
transcriptase
inhibitor)
Deoxynojirimycin
ButyL-DNJ,
N-butyt-DNJ
gtycosylation
Dideoxyadenosine
ddA
Dideoxycytidine
ddC
ddl
21,3,-dideoxycytidine,
HIVID,
FLT
606170
Ro 24-2027
BNY-40900,
Oidanosine,
2',]'-dideoxyinosine,
Fluorothymidine
N-
098700
Zalcitabine,
Oicleoxyinosine
(Protein
inhibitor)
Synthesized
612049
Videx
ftuor-substituted derivative
of dideoxythymidine
GEM 91
May inhibit
GLQ223
Co_pourKJO, Trichosanthin
GP120 vaccine
HIV replication
(Biocine)
GP160 vaccine
Recombinant,
an envelope
HIV immunogen
inactivated
virus
Freund's
adjuvant
protein
incorporated
from HIV
inmodified
HPA-23
Human Growth
Hormone
Hydroxychtoroquine
Sulfate
Protropin
(recon_inant
Therapy for HIV-retated
Ptaquenit
Sulfate
HYl_ericin
St Johns Wort
92
Table of Contents
Manuals
svno_ and
Generic
Name
Short
Names
Brand
or Trade Names
Growth
Factor
+NSC No.
NIV Infection
(toni'd)
IGF-1
Imreg- 1
Imuthiol
DTC
Interferon
Beta
Interferon
Gamma
Ser 17
]nterteukin-2,
IL-2,
Interleukin-2
ACTG 166
Fusion
Interieukin-3
L_phokine;
expansion
results
in
of act ivated
proliferation
T- lymphocytes
and
Toxin
IL-3
Regulates
proliferation
of hematopoietic
and
and differentiation
lymphoid cells
Pyridinone
L-697639
L-697661
(I_ibits
Lent inan
NDL 28574
MN rgp120/HlV-
Nyristic
analogs
acid
Prevents
assembly
_t_roteins
of
neu virus
from
NAC
Mucowst,
N-acetyl
cysteine
(Cysteine
may indirectly
inhibit
HIV reptication)
OTC
Procysteine,
PEG-IL-2
Polyethylene-glycol
Pentamidine
Pentoxifyl
Pept ide
Isethionate
line
cysteine
Pentam 300,
Trental
precursor
derivatized
Anci I lary
PMEA
Inhibits
HIV replication
Pneumovax
93
IL-2
RP 2512
(see also
precursor;
620107
Drugs)
Table of Contents
Manuals
Generic
Name
Short
Names
synonymand
Drugs UsedTo
Protease
inhibitor
Treat
+NSC No.
HIV Infection
Ro 31-8959 (Inhibits
enzyme necessary
for
functionaL,
infectious
(Cont'd)
the protease
formation
of
virions
reD4
R_tin
(Rec_inant
rgp120 CHO
Biocine
rgp120/HiV-1 (llIS)
Solulole (:I)4)
Riloavirin
Virazole
Ro 24-7429
sT4
Recombinant Sotulole T4
3TC
Lamivudine,
Analogue
HIV replication
termination
Thymic Humorat
THF
Factor
Thymopentin
Increases
TIBO derivatives
viral
inhibits
DNA chain
number of T-tymphocytes
cell-mediated
TP-5
of cytidine;
through
and augments
immunity
R 62913
(Non-nucteoside
reverse
transcriptase
inhibitor)
U-85961
(bis(heteroaryt)piperazine
U-87201E
Non-nucleoside
colqoound (BHAP)
reverse
transcriptase
(bis(heteroaryl)piperazine
U-90152
BHAP compound
VaxSyn
Recombinant
Wobenzym
Suppresses
patients
Zidovudine*
935U83
AZT
(see Azidothymidine,
Inhibits
response
Section
94
inhibitor
compound (BHAP)
in AIDS
1.)
transcriptase
602670
Table of Contents
Manuals
Generic
Marne
Sl_rt
Names
Sodium
Alpha
Trade
Infections
acid
Interferon
Sulfate
Amphotericin
(Rx of
AMB
Complications
agent;
investigation
Rx of
Kaposi's
antiviral)
Rx of microsporidiosis
for
Rx of
Kaposi's
sarcoma
sarcoma
(antimycobacterial
Fungizone,
kssociatedWith
Under
Amikin
Memes
And Other
AntifungaL
retinoic
Amikacin
or
Zovirax
AlbendazoLe
All-trans
Opportunistic
synon_sand
Brand
drug)
Component of Mysteclin-F#
(antifungaL)
Amphotericin
Anti-B4-btocked
B Lipid
CotqpCex
(ABLC)
Ricin
Ara-C
Cytarabine
(under
Progressive
Atovaquone
Mepron,
investigation
Muttifocal
566 (therapy
pneumonia;
under
for
Rx of
Leukoencephatopathy
for
Pneumocystis
investigation
for
(PML))
carinii
Rx of
cryptosporidiosis)
Azithromycin
Zithromax
for
(Rx of Chiamydia;
toxoptasmosis,
BACI
Bactrim/Septra
TMPJSMX
Butoconazole
under
Rx of MycobacteriumAvium
investigation
Coo_ptex (MAC),
and cryptosporidiosis
Bovine
anti-Cryptosporidium
(Under
investigation
for
Cotrim,
Trimethoprim
Femstat
(topical
Immunogtoloulin
Rx of cryptosporidiosis)
(TMP)-sutfamethoxazoLe
antifungat
agent)
BV ara-U
BU 256_J87
BW 348U87
BU 88ZC87
Capreomycin
Sulfate
Capastat
Ceftriaxone
Sodium
Rocephin
Ciproftoxacin
HCL
Cipro
sulfate
(antimycobacteriat
(antimycobacteriat
95
drug)
drug)
(SMX)
AIDS
Table of Contents
Manuals
Generic
Name
Short
Mames
Opportunistic
Syno_usand
Infections
And Other
+NSC No.
CompLications
Associated
Clarithr_cin
Biaxin (anti_co_cterial
Clinda_cin
C[ofazimine
l_rene
C[otrimazole
With
AIDS
drug)
(anti_co_cteriat
drug)
141046
Cytomegatovirus
Corticosteroids,
adjunctive
Rx of
Pneumocystis
Cycloserine
Ser_cin
Dapsone
Antiparasitic
Daunorubicin,
Dextran
liposome-encapsulated
Sulfate
Immune Globulin
pneumonia
(anti_cobacteria[
carinii
drug)
006091
Daunoxone
Uendex
Dianoxide Furoate
Antibiotic; Rx of amebiasis
Doxorubicin,
[iposome-encapsutated
Dronabino[
See Tetrahydrocannabino[
Econazote
Spectazote
EfLornithine
HCL
Erythropoietin
DFMO
Ornidy[
Ethambuto[
HCL
(Rx of Pneumocystis
Epoietin
(stimuLates
Myambuto[
stimulant)
(Under
Atfa,
pneumonia
Eprox,
carinii)
rHu-EPO,
RBC production)
investigation
for
Rx of
Trecator-SC
Famciclovir
BRL 39123A
Fansidar
ProphyLaxis
FIAU
(Rx for
134454
(antifunga[)
EPO Epogen,
Procrit
(appetite
(antimycobacteriat
for
cytomegatovirus)
96
dru9)
628281
Table of Contents
Manuals
Generic
Name
Short
Drugs UsedTo
Names
Treat
Opportunistic
Ftuconazote
Sodium
Names
lnfectionskndOther
Diftucan
Ftucytosine
Foscarnet
sy_nym and
Brand or Trade
+MSC No.
CompticationsAssociatedgith
(antifungat;
5-FC
Ancobon (antifungat;
PFA
EHB 776,
Rx of
Furazotidone
Foscavir,
Furoxone
of
G-CSF
Gancictovir
to An_hotericin
Trisodium
phosphonoformate
retinitis
(Antimicrobiat
and HSV
used in
Fitgrastim,
Neupogen (Granutocyte
stimulating
factor;
Adjunct
treatment
the oral
RX
Colony-
of Gancictovir
of neutropenia
Actimmune
DHPG, 2=NDG
BIOLF-62,
BW 759U,
Cytovene,
(Rx of AIDS-reLated
GR-CSF
Leukine,
RS-21592
retinopathies)
Sargramostim
colony-stimulating
(Granutocytemacrophage
factor
Guanfacine
Rx of AIDS Dementia
Complex
HPNPC
Under investigation
infections
of
Imipenem-Citastatin
Primaxin,
component of (antibiotic;
antilrr/cobacteriat)
Iodoquinol
Yodoxin
Isoniazid*
B)
giardiasis
therapy;
Gamma Interferon
Candidiasis)
adjunct
(Rx of cytomegatovirus
infections)
AIDS
IHH
(Antibiotic;
Cotinazin,
Niconyl#,
acid
Hidaton#,
Teebaconin,
Tisin#,
CNV
Rx of amebiasis)
Dinacrin#,
Isonicotinic
asymptomatic
Ditubin#,
hydrazide,
Nydrazid,
Isotyn#,
Laniazid,
Rimifon#,
Tyvid#
]soprinosine
Itraconazote
ITZ
R-52,211,
Sporonax
(antifunga[)
(Rx of Candidiasis)
IVIG
Intravenous
immunoglobulin;
provides
passive
immunity (viral
infections)
Ketoconazote
(antifungal)
L-693,989
Activity
against
97
Table of Contents
Manuals
_--
synom_____
Generic
Name
Short
Names
Opportunistic
Infections
And Other
+NSC No.
CompLications
Associated
Letrazurit
Rx of Cryptosporidiosis
L_til
Anti-diarrhea
Malathion
Megestrol Acetate
Hetronidazole
Flagyl,
Metro
Component of Flagyl
I.V.,
Protostat,
I.V.
RTU,
050364
Satric
(Rx of microsporidiosis)
Mexiletine
HCI
Nexitil
Niconazole
Nicatin,
NSL-109
Antiviral
(Therapy
for
Nonistat
(topical
monoclona[
against
HIV-related
neuropathy)
antifunga[
antibody
with
agent)
activity
CMV strains
Nucopirocin
gactroban
Ni_ipine
Nystatin
Nycostatin,
Bilstat,
Rycolog
component of Nyco-Triacet
If,
component of Rytrex,
Terrastatin,
Para-aminosaticytic
Ftoxin
acid
component of
antibiotic)
(antimycobacteriat
PAS, Teebacin
drug)
(antimycobacteriat
Paromomycin Sulfate
Humatin (antibiotic)
(Under
for Rx of cryptosporidiosis
Peftoxacin
Under
investigation
98
component of
component of Tetrastatin
(topical
antif,_gat
(Rx of Candidiasis)
Ofloxacin
Nystex,
for
drug)
investigation
Rx of PCP
With AIDS
II,
Table of Contents
Manuals
Generic
Name
Drugs
Short
UsedTo
Names
Treat
Pentamidine
Opportunistic
s,r,ce,_sand
lnfectionsAndOther
Lomidine,
Peptide
Under
ColpLicatiom
NebuPent,
prophylaxis
Permethrin
PtateLet
the
lsethionate
Factor
AIDS
(Rx or
Rx of HIV-associated
gtuconate
agent
and neuopathy
(Under
of ora[
used for
investigation
candidiasis
ectoparasites)
Rx of PCP
Under
Podofitox
investigation
Condytox
Primaquine
for
impairment
prevention
(topical
Piritrexim
Pentam 300
investigation
Chtorhexidine
for
AssociatedUith
of PCP) (antiparasitic)
neuropsychiatric
Peridex
+NSC No.
Phosphate
Used in
for
Rx of
Kaposis's
with
virus
Ctindamycin
sarcoma
(HPV)
for
Rx of
PCP (antiparasitic)
Pyrantet
Pamoate
Pyrazinamide
(antihetminthic)
PZA
Pyrimethamine
Rx of tuberculosis
Daraprim,
(Rx of
Quinacrine
Atabrine
Ranitidine
Retinoic
Component of
toxoplasmosis)
HCL
Acid
Rifaloutin
Fansidar,
(antiparasitic)
Zantac
(Rx of moLtuscumcontagiosum
Ansamycin,
virus)
Mycobutin
113926
(Rx of Mycobacteri_Avi_
Rif_in
Matocide
(antiparasitic)
complex (MAC))
Rifadin, Ri_ctane
(Under investigation for Rx of MAC; Rx of
tubercutosis)
SP-PG
Inhibits
for
angiogenesis;
Rx of Kaposis's
Sparftoxacin
(antimycobacterial)
Spiramycin
Rx of cryptosporidiosis
99
under
investigation
sarcoma
055926
Table of Contents
Manuals
svnm_sand
Generic Name
Short flames
DrugsUsedTo
Spiramycin
Treat
Ol_portunistic
+IliSC
lio.
|nfectionsAnclOtherCelqplicationsAssociatedWith
AIDS
HCL
06_393
Streptomycin
Sulfadiazine
(antiparasitic)
Sulfamethoxazote
Rx of PCP
Terconazote
Terazot
Thiabendazole
Mintezot
(Rx of strongytoidiasis)
Tioconazote
Vagistat
(antifungat)
TLC G-65
Rx of HycolbacteriumAviumComptex
TNP-470
AGN-1470#
(inhibits
See F3TDR
Trifturidine
TFT
Viroptic,
Trimethoprim
THP
Trimpex,
(topical
antifungat
agent)
angiogenesis)
ProLoprim
075520
(Rx or prophylaxis
of PCP)
(antiparasitic)
Trimetrexate
Trospectomycin
Salvage
Sulfate
therapy
Antibiotic
gonorrhea;
for
PCP
NycobacteriumAviumCocMolex
Vidarabine
WR 6026
Therapy
for
566C80
)00
Pneumocystis
carinii
pneumonia
106568
Table of Contents
Manuals
NOTES
101
Table of Contents
Manuals
102
Table of Contents
Manuals
PROTOCOL INVESTIGATORS
AFIP
AJC
AMLI
BTSG
BTS
CALGA
CALGB
CCSG
CCDEP
COG
CRC
DFCC
ECOG
EORTC
ESSG
FDA
FIGO
GITSG
GOG
HNCP
HTSG
IARC
IFAC
INTERG
IRS
LCSG
MAOP
MARCOG
NABMTG
NCCTG
NCI
NCOG
NETDC
NORCA
NPCTG
NSABP
NWTS
UORG
POA
POG
PVACCG
PVSG
103
and Treatment
Group
of
Table of Contents
Manuals
104
Table of Contents
Manuals
SELECTED
BIBLIOGRAPHY
105
Table of Contents
Manuals
106
Table of Contents
Manuals
SELECTED BIBLIOGRAPHY
American
Index of Drugs.
Philadelphia:
J.B. Lippincott
Co., 1981.
Cancer Treatment
Reports, National Cancer Institute.
Documents, U. S. Government Printing Office.
Washington,
Drug Bulletin.
of Community
Superintendent
Association
D.C.:
2nd ed.
Cancer Centers.
Institutes
of
Information
Philadelphia:
DeVita, Vincent T. Jr., M.D.; Heilman, Samuel, M.D.; and Rosenberg, Steven A., M.D., Ph.D.
Cancer: Principles and Practice of Oncology. Philadelphia:
J. P. Lipincott, 1982.
Diseases of the Lymphatic
York: Springer-Verlag,
Edited by D.W.
Handbook.
Molander,
New York:
Frei, Emil, III, M.D., and Holland, James F., M.D. Cancer Medicine.
1973.
Elsevier,
Philadelphia:
M.D.
New
1980.
Lea
& Febiger,
Organization,
1976.
Knobf, Mary K. et al. Cancer Chemotherapy Treatment and Care. Edited by M.E. Morra.
Haven: Communications
Office, Yale Comprehensive
Cancer Center, 1979.
New
Mondell,
Classification
Walter, ed.
Drugs of Choice.
Montvale,
St. Louis:
NJ:
World Health
Medical Economics
1978-1979.
Data, 1993.
Rubin, Philip, M.D., ed. Clinical Oncologyfor Medical Students and Physicians. 6th ed. Rochester:
The University of Rochester School of Medicine and Dentistry and the American Cancer Society,
Inc., 1983.
107
Table of Contents
Manuals
I08
Table of Contents
Manuals
DRUG INDEX
109
Table of Contents
Manuals
110
Table of Contents
Manuals
BOOK 8 INDEX
8075 C.B. (see Oxandrolone*),
79
016895 (see Lithium Carbonate),
43
085791 (see Ethacrynic Acid), 41
111180 (see Acetylcysteine),
39
12,540 (see Tubercidine),
27
131 I (see I 131), 63
144 A1 (see Aclarubicin),
15
24281 (antibiotic) (see Mitocarcin),
23
27-400 (see Cyclosporine),
62
29060-LE (see Vinblastine* Sulfate), 27
296961 (see WR 2721), 41, 46
3123L (see Puromycin (HCI)), 25
31595C (see Mitosper),
23
32379 (see Dromostanolone
Propionate),
75
32645 (see Vinleurosine Sulfate#),
28
33379 (see Flurandrenolide),
76
36781 (see Vinrosidine Sulfate#),
28
37231 (see Vincristine*
Sulfate), 28
38000 (see Clometherone#),
74
38489 (see Nortriptyline HCI), 44
47599 (see Pyrazofurin#),
25
49040 (see Vinglycinate Sulfate), 28
49825 (see Nylestriol),
79
5052 (see Acetyclysteine),
39
5071 (see Megestrol Acetate),
78
515776 (see Dipyridamole),
41
5278 R.P. (see Streptonigrin),
25
5373 (see Melengestrol Acetate), 78
566 (see Atovaquone),
95
566C80, 100
59156 (see Enpromate#),
20
630 (see Gosrelin),
77
68618 (see Mycophenolic acid), 51
79T61 (see 9-Ethyl-6-Mercaptopurine),
20
A
A-20968 (see Piposulfan),
24
A-2371 (see Plicamycin*),
24
A-4942 (see Ifosfamide*),
21
A-8103 (see Pipobroman*),
24
A-hydroCort
(see Hydrocortisone Sodium Succinate),
77
A-methaPred
(see Methylprednisolone
Sodium Succinate),
111
78
Table of Contents
Manuals
A (continued)
A-Ninopterin (see Aminopterin),
15
A-TD (see Aminothiadiazole),
15
AAFC (see Flurocitabine#),
20
AB-100 (see Uredepa), 27
AB-103 (see Benzodepa),
16
AB-132 (see Meturedepa),
23
Abbott 43818 (see Leuprolide Acetate), 77
Aberel (see Tretinoin), 51
Abirol (see Methandrostenolone),
78
ABLC (see Amphotericin B Lipid Complex), 95
Aburamycin B (see Chromomycin A3#), 17
AC-1075 (see Cytarabine HC1), 18
5-AC (see Azacitidine), 51
Accutane (see Retinoic acid), 51
ACD (see Dactinomycin*),
18
Acethropan (see Adrenocorticotropic hormone), 73
Acetyladriamycin (see Daunorubicin (HCI)*), 18
Acetylcysteine,
39
Acitretin, 51
Acivicin, 15
Aclacinomycin (see Aclarubicin ), 15
Aclacinomycin-A#
(see Aclarubicin ), 15
Aclacinon (see Aclarubicin ), 15
Aclarubein (see Aclarubicin ), 15
Aclarubicin,
15
ACM (see Aclarubicin ), 15
ACM-A (see Aclarubicin ), 15
Acodazole (HCI), 15
ACPC (see Cycloleucin), 18
ACR (see Aclarubicin ), 15
Acrichin (see Quinacrine (HCI)), 45
Acridinyl anisidide (see Amsacrine), 15
Acrinamine (see Quinacrine (HCI)), 45
Acriquine (see Quinacrine (HCI)), 45
Acronine*,
15
Acronycin# (see Acronine*),
15
Acronycine (see Acronine*), 15
ACT (see Dactinomycin*),
18
ACT-D (see Dactinomycin*),
18
ACTD (see Dactinomycin*),
18
ACTG (see Imuthil), 93
ACTH (see Adrenocorticotropic
hormone), 73
ACTH (see Corticotropin),
74
Acthar (see Adrenocorticotropic
hormone),
73
112
Table of Contents
Manuals
A (continued)
Acticort (see Hydrocortisone),
77
Actimmune (Genentech)
(see Interferon Gamma-lb),
63
Actimmune (see Gamma Interferon),
97
Actinex (see Masoprocol),
22
Actinochrysin (see Cactinomycin),
16
Actinomycete fermentation product (see Piperazinedione
compound),
Actinomycm AIV (see Dactinomycin*),
18
Actinomycm C# (see Cactinomycin),
16
Actinomycm C1 (see Dactinomycin*),
18
Actinomycm D (see Dactinomycin*),
18
Actinomycm I1 (see Dactinomycin*),
18
Actinomycm IV (see Dactinomycin*),
18
Actinomycmdioic D acid dilactone (see Dactinomycin*),
18
Acto-D (see Dactinomycin*),
18
Acyclovir Sodium, 95
Acyclovir, 39, 94
ACZ (see Acetazolamide),
39
AD (see Dactinomycin*),
18
ADA Transduced T-cell, 61
ADAH (see Bisantrene (HCI)), 16
Adanon HCI# (see Methadone HCI), 43
ADC (see Bisantrene (HCI)), 16
Adenine arabinoside (see Vidarabine*),
27
Adicillin, 39
ADM (see Doxorubicin (HCI)*), 19
Adozelesin,
15
ADR (see Doxorubicin (HCI)*), 19
ADR-529 (see Dexrazoxane),
19
Adrenal Cortex hormone (see Adrenocorticotropic
hormone),
73
Adrenocorticotrophin
(see Adrenocorticotropic
hormone),
73
Adrenocorticotropic
hormone, 73
Adrenocorticotropin
(see Adrenocorticotropic
hormone),
73
ADRI (see Doxorubicin (HCI)*), 19
Adriamycin (see Doxorubicin (HCI)*), 19
Adriamycin-TM (see Doxorubicin (HCI)*), 19
Adriblastina (Italy) (see Doxorubicin (HCI)*), 19
Adroyd# (see Oxymetholone*),
79
Adrucil (see Fluorouracil*),
20
Aeroseb-Dex
(see Dexamethasone),
40, 74
Aeroseb-HC
(see Hydrocortisone),
77
AG (see Aminoglutethimide),
73
8-AG (see 8-Azaguanine),
15
AGM-1470,
94
AGT (see Aminoglutethimide),
73
113
24
Table of Contents
Manuals
A (continued)
AHR-3070-C (see Metoclopramide (HCI)*), 43
Airol (see Tretinoin), 51
Akrichin (see Quinacrine (HCI)), 45
AL 721, 94
Alanine mustard (see Melphalan* (HCI)), 22
Alanosine, 15
Albendazole,
95
Albuterol, 39
Aldactazide (see Spironolactone),
80
Aldactone (see Spironolactone),
80
Aldesleukin (see Interleukin-2),
63
Alendronate Sodium, 39
Alexan (see Cytarabine HCI), 18
Alferon N Injection (see Interferon Alfa-n3), 63
Algestone* Acetophenide,
73
Alizapride, 39
Alkaloid H-3 (see Colcemid), 17
Alkeran (see Melphalan* (HCI)), 22
All-trans retinoic acid (see Tretinoin), 51, 91
Allergan 211 (see Idoxuridine*), 42
ALLO (see Allopurinol*),
39
Allogeneic bone marrow transplantation (see Allogeneic cells),
Allogeneic cells, 61
Allopur (see Allopurinol*),
39
Allopurinol*,
39
Alpha 1 (see Thymosin ), 66
Alpha Interferon,
91
Alpha TGI (see Teroxirone),
26
Alpha-DFMO
HCI (see DFMO), 19
Alpha-Difluoromethylornithine
(see DFMO), 19
Alpha-TGdR,
15
Alphadrol#
(see Fluprednisolone*),
76
Alphatrex (see Betamethasone Dipropionate),
73
Alprazolam,
39
Altretamine*,
15
Arnadinone Acetate, 73
AMB (see Amphotericin B), 95
Ambochlorin (see Chlorambucil*),
17
Ambomycin, 15
Amcinonide,
73
Amedel (see Pipobroman*),
24
Ametantrone Acetate, 15
Amethopterin#
(see Methotrexate*),
22
Ametycine (see Mitomycin*), 23
Amidohydrolase
(see (Escherichia coil)), 61
114
61
Table of Contents
Manuals
A (continued)
Amifostine (see WR 2721), 46
Amifostine,
39
Amikacin Sulfate, 95
Amikin (see Amikacin Sulfate),
95
Aminobenzoate
Potassium,
39
Aminoglutethimide,
73
Aminopteridine
(see Aminopterin),
15
Aminopterin,
15
Aminopterin sodium (see Aminopterin),
15
Aminosyn, 39
2-Amino-l,3,4-thiadiazole
(see Aminothiadiazole),
15
Aminothiadiazole,
15
Amiodarone,
39
Amnestrogen#,
(see Estrogens, Esterified),
76
Amonafide (see Nafidimide),
23
Amonafide HC! (see Nafidimide), 23
Amphotericin B, 91
Amphotericin B Lipid Complex, 95
Ampligen (see Poly I: Poly C12U), 65
Ampligen, 91
AMSA (see Amsacrine),
15
Amsacrine,
15
Amsidyl (see Amsacrine),
15
AMX (see Azimexon),
61
Anabolin (see Methandrostenolone),
78
Anadrol (see Oxymetholone*),
79
Anagestone Acetate, 73
Anatropin#
(see Anagestone Acetate), 73
Anavar (see Oxandrolone*),
79
Anaxirone (see Triglycidylurazol),
27
Ancitabine hydrochloride (see Cyelocytidine (HCI)), 17
Ancobon (see Flucytosine),
97
Ancortone (see Prednisone),
79
Ancyte# (see Piposulfan),
24
Andro 100 (see Testosterone),
80
Andro L.A. 200 (see Testosterone Enanthate),
80
Androfluorene
(see Fluoxymesterone),
76
Androgen L.A. (see Testosterone Enanthate),
80
Androgyn L.A. (see Estradiol),
75
Androgyn L.A. (see Testosterone Enanthate),
80
Androgyn L.A. (see Testosterone),
80
Andrometh (see Methyltestosterone),
78
Androsan (see Methyltestosterone),
78
Androsten (see Methyltestosterone),
78
115
Table of Contents
Manuals
A (continued)
Anergan 25 (see Promethazine HCI*), 45
Anergan 50 (see Promethazine HCI*), 45
Anertan (see Methyltestosterone),
78
Anestacon (see Lidocaine),
43
ANG (see Anguidine),
15
ANG 66 (see Anguidine),
15
Anguidin (see Anguidine),
15
Anguidine,
15
Aniline mustard, 15
Anisene (see Chlorotrianisene),
74
Anrosterolo (see Fluoxymesterone),
76
Ansaid (see Flurbiprofen),
41
Ansamacrolide compound (see Maytansine), 22
Ansamycin (see Rifabutin), 99
Antabuse, 91
Anthramycin,
15
Anthrapyrazole C 1941, 15
Anthrapyrazole Dihydrochloride (see Piroxantrone HCI), 24
Anti-B4-biocked Ricin, 95
Anti-Thymocyte Globulin, 61
Antibiotic 1037 (see Toyocamycin), 27
Antibiotic 1719 (see Azotomycin), 16
Antibiotic A 23813 (see Pyrazofurin#),
25
Antibiotic AT-125 (see Acivicin), 15
Antibiotic B 599 (see Chromomycin A3#),
17
Antibiotic CI-920 (see Fostriecin Sodium), 20
Antibiotic CL 1565A (see Fostriecin Sodium), 20
Antibiotic E 212 (see Toyocamycin), 27
Antibiotic LA 7017 (see Plicamycin*), 24
Antibiotic MA (see Aclarubicin ), 15
Antibiotic U-18,496 (see Azacitidine), 51
Antibiotic XK 101-1 (see Tubercidine), 27
Anticea, 1-131, 61
Antiferritin antibodies, 1-131, 61
Antiferritin antibody (see Anticea), 63
Antifolan (see Methotrexate*),
22
Antimalarina (see Quinacrine (HCI)), 45
Antiren (see Piperazine),
44
Antramycin (see Anthramycin),
15
Antrypol (see Suramin Sodium), 26
APGA (see Aminopterin),
15
Aphidicolin Glycinate,
15
Aphidicolin-17 glycinate (see Aphidicolin Glycinate), 15
Aplisol (see Tubercidine),
27
116
Table of Contents
Manuals
A (continued)
Aquadiol# (see Estradiol),
75
Ara-A (see Vidarabine*),
27
Ara-AC (see Fazarabine),
20
Ara-adenosine
(see Vidarabine*),
27
Ara-C (see Cytarabine HCI), 18
Ara-C (see Cytarabine),
51
Ara-C, 51, 95
Ara-cytidine (see Cytarabine HCI), 18
Arabinocytidine
(see Cytarabine HCI), 18
Arabinosyladenine
(see Vidarabine*),
27
Aristocort (see Triamcinolone
Diacetate),
81
Aristocort (see Triamcinolone),
81
Aristocort forte parenteral (see Triamcinolone Diacetate),
81
Aristospan (see Triamcinolone Hexacetonide),
81
Armour Thyroid (see Thyroid), 81
Arsanilic acid (see AS-101), 91
AS-101, 91
Asalex (see Asaley), 15
Asaley, 15
Asnase (see Asparaginase),
61
ASP (see Asparaginase),
61
ASPA (see Asparaginase),
61
Asparaginase
(Erwinia carotovora),
61
Asparaginase,
61
Asparaginase-PEG
(K-H), 61
Asperlin#,
15
Asta B 518 (see Cyclophosphamide*),
18
Asta Z-4942 (see Ifosfamide*),
21
Autologous,
61
Autologous Lymphocytes (see ADA Transduced T-cell), 61
Autologous Tumor Cell Vaccine (see Autologous),
61
Aventyl (see Nortriptyline HCI), 44
Avinar# (see Uredepa),
27
AY-11,440 (progestin)
(see Clogestone* Acetate),
74
AY-62022 (progestin) (see Medrogestone),
77
Ayr (see Sodium Chloride),
45
5-AZA (see Azacitidine),
51
5-AZAC (see Azacitidine),
51
Azacitidine,
51
Azacytidine (see Azacitidine),
51
5-Azacytidine (see Azacitidine),
51
5-Aza-2'Deoxycytidine,
15
Azaguanine (see 8-Azaguanine),
15
Azan (see 8-Azaguanine),
15
117
Table of Contents
Manuals
A (continued)
Azanin (see Azathioprine*),
16
Azapicyl, 15
Azaribine*,
15
AZAS (see Azaserine*#),
16
Azaserin (see Azaserine*#),
16
Azaserine*#,
16
AzAT (see Azathioprine*),
16
Azatepa (see Azetepa#),
16
Azathioprin (see Azathioprine*),
16
Azathioprine*,
16
Azatioprin (see Azathioprine*),
16
6-Azauracil riboside (see 6-Azuridine), 16
Azauridine (see 6-Azuridine), 16
6-Azauridine (see 6-Azuridine),
16
6-Azauridine triacetate (see Azaribine*), 15
AZC (see Azacitidine),
51
5-AZCR (see Azacitidine),
51
Azetepa#,
16
AZG (see 8-Azaguanine),
15
3'-Azido-3' deoxythymidine (see Zidovudine*),
28
Azidothymidine,
16, 91
Azidouridine,
91
Azimexon, 61
2-aziridinecarboxamide
compound (see Azimexon), 61
Aziridinyl Benzoquinone (see Diaziquone),
19
Aziridinyl cyclohexane (see Cyclohexanecarboxamide),
18
Azithromycin, 95
Azmacort (see Triamcinolone Acetonide),
81
5-azocytosine arabinoside (see Fazarabine),
20
Azo Gantanol, component of (see Sulfamethoxazole),
46
Azolastone (see Mitozolomide),
23
AZOT (see Azotomycin),
16
Azothioprine
(see Azathioprine*),
16
Azotomycin,
16
AZQ (see Diaziquone),
19
AZR (see Azaribine*),
15
AZS (see Azaserine*#),
16
AZT (see Azidothymidine),
16, 91
AZT (see Zidovudine*),
28, 94
AzUR (see 6-Azuridine),
16
6-Azur (see 6-Azuridine),
16
6-Azuridine,
16
118
Table of Contents
Manuals
B
B 35251 (antibiotic) (see Mitocromin),
23
B-2' Deoxythioguanosine
(see Beta-TGdR),
16
B-28 (see 8-Azaguanine),
15
B-S-P (see Betamethasone
Sodium Phosphate),
73
Ba 24648 (see Cyclohexanecarboxamide),
18
Ba 41166/E (see Rifampin),
25
Ba-16038 (see Aminoglutethimide),
73
Babidium chloride (see Ethidium chloride), 20
BACI, 61
Bacillus Calmette-Guerin
(see BCG), 61
Bactrim, component of (see Sulfamethoxazole),
46
Bactrim, component of (see Trimethoprim),
46
Bactrim/Septra,
39, 95
Bactroban (see Mucopirocin),
98
BAF (see Baker's antifol), 16
Baker's antifol, 16
Baker's antifolante (see Baker's antifol), 16
Bamide (see Hydroxyurea*),
21
Basoprocin (see Liothyronine Sodium), 77
Batanopride HCI, 39
BAY G6575 (see Nafazatrom),
23
Bayer 205 (see Suramin Sodium), 26
BBM-2478A (see Elsamitrucin),
19
BCG, 61
BCM (see Mannomustine),
43
BCNU (see Carmustine*),
17
BDH-1298 (see Megestrol Acetate), 78
BDH-1921 (see Melengestrol Acetate),
78
BDU (see Bromodeoxyuridine),
39
5-BDU (see Bromodeoxyuridine),
39
Beclometasone
(see Beclomethasone Dipropionate),
Beclomethasone
Dipropionate,
73
Beclovent (see Beclomethasone Dipropionate),
73
Beconase (see Beclomethasone
Dipropionate),
73
Beesix (see Pyridoxine HCI), 45
Belustine (nitrosourea)
(see Lomustine*),
21
Benadryl (see Diphenhydrarnine
HCI), 41
Benisone#
(see Betamethasone
Benzoate),
73
Benorterone#,
73
119
73
Table of Contents
Manuals
B (continued)
Benylin, component of (see Diphenhydramine HCI), 41
Benzcarbimine (see Benzodepa),
16
Benzestrol, 73
Benzisoquinolenedione
(see Nafidimide), 23
Benznidazole,
39
Benzodepa,
16
Benzoyl hydrazone daunorubicin (see Zorubicin (HCI)),
Benzquinamide,
39
Bestatin, 61
Beta Carotene,
39
Beta-Arabinosylcytosine
(see Cytarabine HCI), 18
Beta-TGdR,
16
Beta-Val (see Betamethasone Valerate),
73
Betamethasone,
73
Betamethasone Acetate, 73
Betamethasone Benzoate,
73
Betamethasone Dipropionate,
73
Betamethasone Sodium Phosphate, 73
Betamethasone Valerate,
73
Betapar# (see Meprednisone*),
78
Betaseron (see Interferon Alfa-2b), 63
Betatrex (see Betamethasone Valerate),
73
BI-RG-587, 91
Biaxin (see Clarithromycin),
96
BIC (see TIC-mustard),
27
BiCNU (see Carmustine*),
17
BIDA (see Nafidimide), 23
Bio-Des (see Diethylstilbestrol),
75
Biocine (see rgpl20 CHO), 94
BIOLF-62 (see Ganciclovir), 97
Biorex, England (see Carbenoxolone Sodium), 73
Biostim, 62
Bisantrene (HCI), 16
Bisantrene (see Bisantrene (HCI)), 16
Bisbenzamide (see Pibenzimol HCI), 24
Bisbenzimidazole (see Pibenzimol HCI), 24
BL 191 (see Pentoxifylline),
44
BLE (see Bleomycin Sulfate), 16
Blenoxane (see Bleomycin Sulfate), 16
BLEO (see Bleomycin Sulfate), 16
Bleomycin (see Bleomycin Sulfate), 16
Bleomycin Sulfate, 16
BLM (see Bleomycin Sulfate), 16
Bloxanth (see Allopurinol*),
39
120
28
Table of Contents
Manuals
B (continued)
BM 41,440 (see Ilmofosine),
21
BM-25801-01
(anti-emetic) (see Batanopride HCI), 39
BMY-28090 (see Elsamitrucin),
19
BMY-40900 (see Dideoxyinosine),
92
BMY-41606 (see Vapreotide),
27
Bolasterone#,
73
Borocaptate Sodium B 10, 39
Borolife (see Borocaptate Sodium B 10), 39
Bovisynchron (see Chlormadinone*
Acetate),
73
BrdUrd (see Bromodeoxyuridine),
39
Brequinar Sodium, 16
Brevicon, component of (see Ethinyl Estradiol),
76
BRL 39123A (see Famciclovir), 96
BRL 61063 91
BRL-43694 (see Granisetron),
42
Bromacrylide#,
16
Bromocryptine,
62
Bromodeoxyuridine,
39
5-Bromodeoxyuridine
(see Bromodeoxyuridine),
39
5-Bromodesoxy-uridine
(see Bromodeoxyuridine),
39
Bromoergocryptine
(see Bromocryptine),
62
Bromouracil deoxyriboside (see Bromodeoxyuridine),
39
Bropirimine,
16
Broxuridine (radiosensitizer)
(see Bromodeoxyuridine),
39
BRU (see Bruceantin),
16
Bruceantin,
16
Bruneomycin (see Streptonigrin),
25
Bryostatin,
16
BSF (see Busulfan*),
16
BSO, 42
BST (see Bestatin),
61
BTGR (see Beta-TGdR),
16
BTIC (see TIC-mustard),
27
BTS 18,322 (see Flurbiprofen),
41
BU (see Busulfan*),
16
BU-2231A (see Talisomycin),
26
BUdR (see Bromodeoxyuridine),
39
5-BUDR (see Bromodeoxyuridine),
39
BUS (see Busulfan*),
16
Busrelin Acetate, 73
BUSU (see Busuifan*),
16
Busulfan*,
16
Busulphan (see Busulfan*),
16
Butoconazole,
95
121
Table of Contents
Manuals
B (continued)
Butyl-DNJ (see Deoxynojirimycin), 92
BV ara-U, 95
BW 256U87, 95
BW 348U87, 95
BW 50-63 (see Pyrimethamine),
45
BW 57-322 (see Azathioprine*),
16
BW 759U (see Ganciclovir), 97
BW 882C87, 95
BW A 509U (see Azidothymidine),
16, 91
BW A 773U, 16
BW A509U (see Zidovudine*),
28
BW A770U mesylate (see Crisnatol mesylate),
BW-56-158 (see Allopurinol*), 39
BW-57-323 (see Thiamiprine), 26
17
C
C.F. (see Leucovorin (calcium)*), 43
C.p. (see C-parvum), 62
C.P. 15,467-61 (see Lithium Carbonate),
43
C-12669 (see Colcemid), 17
C-parvum, 62
CA (see Cytarabine HCI), 18
CACP (see Cisplatin*), 17
Cactinomycin,
16
CAL (see Calusterone),
73
Cal-Sup (see Calcium Carbonate),
39
Caladryl, component of (see Diphenhydramine HCI), 41
Calan (see Verapamil (HCI)*), 46
Calcimar (see Calcitonin*), 39
Calcitonin*, 39
Calcium Carbonate, 39
Calcium folinate (see Leucovorin (calcium)*), 43
Calcium Gluconate, 39
Calcium leucovorin (see Leucovorin (calcium)*), 43
Calusterone,
73
CAMP (see Camptothecin),
16
Camptothecin,
16
Camptothecine sodium (see Camptothecin),
16
Canestin (see Clotrimazole), 96
Cannabinol (see Tetrahydrocannabinol),
46
CAP (see Chlormadinone* Acetate), 73
Capastal sulfate (see Capreomycin Sulfate), 95
Capreomycin Sulfate, 95
122
Table of Contents
Manuals
C (continued)
Caracemide,
16
Carafate (anti-ulcerative)
(see Sucralfate), 46
Carbamohydroxamic
acid (see Hydroxyurea*),
21
Carbamohydroximic
acid (see Hydroxyurea*),
21
Carbamoyl oxime (see Hydroxyurea*),
21
Carbenoxolone
Sodium, 73
Carbetimer,
17
Carbomycin (see Magnamycin),
22
Carbomycin A (see Magnamycin), 22
Carboplatin*,
17
Carbowax Sentry (see Polyethylene Glycol), 44
5-Carboxyanilino-2-thiobarbituric
acid (see Merbarone),
22
Cardizem (vasodilator, calcium influx inhibitor) (see Diltiazem
Carminomicin I (see Carubicin (HCI)), 17
Carminomycin (see Carubicin (HCI)), 17
Carminomycin HCI# (see Carubicin (HCI)), 17
Carminomycin I (see Carubicin (HCI)), 17
Carmustine*,
17
Carmustinea (see Carmustine*),
17
Cartrax (see Hydroxyzine HCI), 42
Carubicin (HCI), 17
Carubicin (see Carubicin (HCI)), 17
CAS 10403-51-7 (see Mitindomide),
23
Casodex, 73
Castanospermine,
91
Catapres-'VI'S (see Clonidine), 40
CB 1639 (see Cycloleucin),
18
CB 304 (see Azaribine*),
15
CB-10-277,
17
CB-1048 (see Chlornaphazine*),
40
CB-1348 (see Chlorambucil*),
17
CB-3025 (see Melphalan* (HCI)), 22
CB-313 (see Mitotane*),
23
CBDCA (see Carboplatin*),
17
CCNU (see Lomustine*),
21
2-CdA, 17, 62
CD4-IgG 91
CD4-PE40,
91
Ce-Cyd (see Cyclopentenylcytosine),
18
CeeNU (see Lomustine*),
21
Ceftriaxone,
95
Celestone (see Betamethasone),
73
Celestone Soluspan (see Betamethasone
Acetate),
73
Celestone Soluspan (see Betamethasone
Sodium Phosphate),
123
HCL),
73
41
Table of Contents
Manuals
C (continued)
Centrazene (see Simtrazene#),
25
Cephalosprin N (see Adicillin), 39
Cerespann (see Papaverine Disodium), 44
Cerubidine (see Daunorubicin (HCI)*), 18
Cesamet (see Nabilone), 44
Cetacort (see Hydrocortisone),
77
CF (see Leucovorin (calcium)*), 43
CG 30694 (see Edatrexate),
19
CGP 19835A, 62
CGS-16949A (see Fadrazole HCI), 20
Chee-O-Gen (see Ethinyl Estradiol), 76
Chee-O-Genf (see Ethinyl Estradiol), 76
CHIP (see Iproplatin),
21
CHL (see Chlorambucil*),
17
Chloditan (see Mitotane*),
23
Chlodithane (see Mitotane*),
23
Chlor-PZ# (see Chlorpromazine*),
40
Chlorambucil*,
17
Chloraminophene
(see Chlorambucil*),
17
Chlorbutin (see Chlorambucil*),
17
Chlorbutine (see Chlorambucil*),
17
Chlorhexidine gluconate (see Peridex), 99
Chloridin (see Pyrimethamine),
45
Chloridine (see Pyrimethamine),
45
Chlormadinone* Acetate,
73
Chlormadinonu (see Chlormadinone* Acetate), 73
Chlornaftina (see Chlornaphazine*),
40
Chlornaphazin (see Chlornaphazine*),
40
Chlornaphazine*,
96
Chlornaphthin (see Chlornaphazine*),
40
2-Chloro-2'Deoxyadenosine
(see 2 CdA), 17
Chloroethylcyclohexylnitrosourea
(see Lomustine*),
21
Chloromethine-HCl
(see Mechlorethamine
(HCI)*), 22
Chloronaphthina
(see Chlornaphazine*),
40
Chloronaphthine
(see Chlornaphazine*),
40
Chloroquinoxaline
suifonamide (see Chlorsulfaquinoxaline),
Chlorotrianisene,
74
Chlorotrianisine
(see Chlorotrianisene),
74
Chlorotris (see Chlorotrianisene),
74
Chlorozotocin,
17
Chlorpromazine*,
40
Chlorsulfaquinoxaline,
17
Chlortrianizen (see Chlorotrianisene),
74
Cholecalciferol (see Vitamin D), 81
Chromic Phosphate P 32, 74
124
17
Table of Contents
Manuals
C (continued)
Chromomycin A3#,
17
Chromphosphotope#
(see Chromic Phosphate P 32), 74
Chronogyn# (see Danazol),
62
CHX 100 (see Masoprocol), 22
CI 337 (see Azaserine*#),
16
CI 825 (see Pentostatin), 65
CI 904 (see Diaziquone),
19
CI-27,071 (see Descinolone Acetonide#),
74
CI-406 (see Oxymetholone*),
79
CI-673 (see Vidarabine*), 27
CI-880 (miscellaneous agent) (see Amsacrine), 15
CI-881 (see Ametantrone Acetate), 15
CI-882 (see PALA),
24
CI-898 (see Trimetrexate),
27
CI-908 (see Dezaquanine),
19
CI-908 mesylate (see Dezaguanine Mesylate),
19
CI-909 (see Tiazofurin),
26
CI-921, 17
CI-937, 17
Cibacalcin (see Calcitonin*),
39
Cilastatin Sodium, 17
Cimetidine,
40, 92
Cingestol*,
74
Cipro (see Ciprofloxacin),
95
Ciprofloxacin,
40
Cirolemycin*,
17
Cis-Clomiphene
citrate (see Clomiphene* Citrate), 74
Cis-DDP (see Cisplatin*),
17
Cis-Diamminedichloroplatinum
(II) (see Cisplatin*),
17
Cis-Platin (see Cisplatin*),
17
Cis-Platinum II# (see Cisplatin*),
17
Cisplatin*,
17
Cisplatino (Spanish) (see Cisplatin*),
17
Cisplatyl (see Cisplatin*),
17
Citarin L (see Levamisole HCI*), 64
Citostal (see TMCA),
27
Citrovorum factor (see Leucovorin (calcium)*), 43
CL (see Cycloleucin),
18
CL (see Leucovorin (calcium)*), 43
CL 118,532 (see Triptorelin ), 81
CL 184,116 (see Porfimer Sodium), 24
CL 26193 (see Simtrazene#),
25
CL 286,558 (see Zeniplatin),
28
CL-106359 (see Triamcinolone Acetonide Sodium Phosphate),
125
81
Table of Contents
Manuals
C (continued)
CL-14377 (see Methotrexate*),
22
CL-16,536 (see Puromycin (HCI)), 25
CL-216,942 (see Bisantrene (HCI)), 16
CL-232,315 (see Mitoxantrone (HCI)*), 23
CL-25477 (see Azetepa#),
16
CL-34433 (see Triamcinolone Hexacetonide),
81
CL-34699 (see Amcinonide), 73
CL-61965 (see Triamcinolone Acetonide Sodium Phosphate),
81
CL-67310465 (see Pentostatin),
65
Cladribine (see 2-CdA), 17
Clafen (see Cyclophosphamide*),
18
Claphene (see Cyclophosphamide*),
18
Clarithromycin,
96
CLB (see Chlorambucil*),
17
Clindamycin, 39
Clinoril (anti-inflammatory) (see Sulindac), 46
Clocortolone Acetate,
74
Clocortolone Pivalate, 74
Clocortolone trimethyl acetate (see Clocortolone Pivalate), 74
Clofazimine, 96
Clogestone* Acetate, 74
Clomegestone* Acetate, 74
Clomesone,
17
Ciometherone#,
74
Clomiphene A citrate (see Clomiphene* Citrate), 74
Clomiphene* Citrate, 74
Ciordion (see Chlormadinone* Acetate), 73
Clorestrolo (see Chlorotrianisene),
74
Cloronaftina (see Chlornaphazine*),
40
Clorotrisin (see Chlorotrianisene),
74
Clotrimazole,
40
CLS (see Calusterone),
73
CLZ (see Chlorozotocin),
17
CMM (see Carubicin (HCI)), 17
CMVIg,
96
CN 15,757 (see Azaserine*#),
16
Co-Vidarabine (see Pentostatin),
65
Codeine, 40
Coenzyme Q, 40
Colaspase (see Asparaginase),
61
Colcemid, 17
Colcemide (see Colcemid), 17
Colchamin (see Colcemid), 17
Colchicine (see Colcemid), 17
126
Table of Contents
Manuals
C (continued)
Colyte, component of (see Polyethylene Glycol), 44
Combid spansule, 40
Comestrol (see Diethylstilbestrol),
75
Compazine (see Prochlorperazine*),
45
Component of Calcitrel (see Calcium Carbonate),
39
Component of Titralac (see Calcium Carbonate),
39
Compound 112531 (see Vindesine), 28
Compound 133314 (see Trioxifene Mesylate),
81
Compound 17309 (see Methandrostenolone),
78
Compound 42339 (see Acronine*), 15
Compound 593A (see Piperazinedione
compound),
24
Compound Q (see GLQ223),
92
Compound Q, 92
Condylox (see Podofilox), 99
Coparvax (R) (see C-parvum), 62
Copavin (see Papaverine Disodium), 44
Copovithane,
62
Cordarone (see Amiodarone),
39
Cordran (see Flurandrenolide),
76
Corilin, component of (see Giycine), 42
Corstiline (see Adrenocorticotropic
hormone),
73
Cort-Dome (see Hydrocortisone),
77
Cortate acetate (see Desoxycorticosterone
Acetate),
74
Cotter (see Hydrocortisone),
77
Cortef acetate (see Hydrocortisone Acetate),
77
Cortenema (see Hydrocortisone),
77
Corticotrophin
(see Adrenocorticotropic
hormone),
73
Corticotropin
(see Adrenocorticotropic
hormone),
73
Corticotropin,
74
Cortilet (see Fiuorometholone),
76
Cortisone (see Cortisone Acetate), 74
Cortisone Acetate, 74
Cortivazoi#,
74
Cortogen acetate# (see Cortisone Acetate),
74
Cortone acetate (see Cortisone Acetate),
74
Cortril (see Hydrocortisone),
77
Cortril acetate-AS (see Hydrocortisone Acetate),
77
Cortrophin#
(see Adrenocorticotropic
hormone),
73
Cortrosyn (see Cosyntropin*),
74
Corynebacterium
granulosum (see C-parvum),
62
Corynebacterium
parvum (see C-parvum), 62
Cosmegan (see Dactinomycin*),
18
Cosyntropin*,
74
Cotrim (see Bactrim/Septra),
95
127
Table of Contents
Manuals
C (continued),
Cotrim, component of (see Sulfamethoxazole, Trimethoprim),
Coumadin (see Warfarin Sodium*), 46
Cowan I (see Protein A Staphylococcus Aureus), 65
C.P. 15,467-61 (see Lithium Carbonate), 43
CP (see Cyclophosphamide*),
18
CP-16,171 (see Prioxicam), 44
CP-50,556-1 (analgesic) (see Levonantradol HCI), 43
CPAR (see C-parvum), 62
CPD (see Cisplatin*),
17
Cpd 109514 (tranquilizer) (see Nabilone), 44
CPDC (see Cisplatin*),
17
CPDD (see Cisplatin*),
17
CPE-C (see Cyclopentenylcytosine),
18
CPM (see Cyclophosphamide*),
18
CPPD (see Cisplatin*), 17
CPT-11, 17
CPV (see Copovithane),
62
CQS (see Chlorsulfaquinoxaline),
17
CQS, 18
Crasnitin (see Asparaginase),
61
Crein (see Methandrostenolone),
78
Crisnatol (see BW A 773U), 16
Crisnatol mesylate, 17
CSF-GM (H)/Yeast (see CSF-GM), 40
CSF-GM E.coli (Hoechst) (see CSF-GM), 40
CSF-GM, 40, 62
CSF-Granulocyte-Macrophage
(see CSF-GM), 40
CSF-Macrophage,
40
CTB (see Cytembena),
18
CTX (see Cyclophosphamide*),
18
CTY (see Cyclophosphamide*),
18
Cuprol (see Diethyldithiocarbamate),
41
Curdlan Sulfate 92
Curretab (see Medroxyprogesterone
Acetate),
77
CYC (see Cyciocytidine (HCI)), 17
CYC (see Cyclophosphamide*),
18
Cyclo (see Cyciophosphamide*),
18
Cyclo-C (see Cyclocytidine (HCI)), 17
CycloCMP hydrochloride (see Cyclocytidine (HCI)),
Cyclocort (glucocorticoid) (see Amcinonide),
73
Cyclocytidine (HCI), 17
Cyclodisone, 18
Cycloestrol (see Hexestrol), 77
Cyclogesterin# (see Estrogens, Conjugated),
76
128
17
46
Table of Contents
Manuals
C (continued),
Cyclogesterin# (see Progesterone), 80
Cyclohexanecarboxamide, 18
Cycloleucin, 18
Cycloleucine (see Cycloleucin), 18
Cyclopentenylcytosine, 18
Cyclophosphamid (see Cyclophosphamide*), 18
Cyclophosphamide*, 18
Cyclophosphan (see Cyclophosphamide*), 18
Cyclophosphane (see Cyclophosphamide*), 18
Cycloserine, 96
Cyclosporin# (see Cyclosporine), 62
Cyclosporine, 62
Cycrin (see Medroxyprogesterone Acetate), 77
Cyfos# (see Ifosfamide*), 21
CYL (see Cycloleucin), 18
Cynomel (see Liothyronine Sodium), 77
Cyproterone Acetate, 74
Cyren A (see Diethylstilbestrol), 75
CYT (see Cyclophosphamide*), 18
Cytadren (see Aminoglutethimide), 73
Cytarabin (see Cytarabine HCI), 18
Cytarabine HCI, 18, 62
Cytarabine, 51
Cytarabinoside (see Cytarabine HCI), 18
Cytembena, 18
Cytomel (see Liothyronine Sodium), 77
Cytophosphan (see Cyclophosphamide*), 18
Cytosar-U (see Cytarabine HCI), 18
Cytosar-U (see Cytarabine), 51
Cytosine arabinoside hydrochloride# (see Cytarabine HCI), 18
Cytovene (see Ganciclovir), 42, 97
CYTOX (see Cyclophosphamide*), 18
Cytoxan (see Cyclophosphamide*), 18
CYTX (see Cyclophosphamide*), 18
CZT (see Chlorozotocin), 17
D
D 7093 (see Mesna*), 43
D-Tetrandrine, 26
D-TrP6 (LH-RH) (see Decapeptyl), 74
D4T, 92
DAC (see 5-Aza-2'Deoxycytidine), 15
DAC (see Decitabine), 18
129
Table of Contents
Manuals
D (continued)
Dacarbazine*,
18
Dacortin (see Prednisone),
79
Dact (see Dactinomycin*),
18
Dactinomycin D (see Dactinomycin*),
18
Dactinomycin*,
18
DAG (see Dianhydrodulcitol),
19
Dalalone (see Dexamethasone Sodium Phosphate),
75
Dalalone D.P. (see Dexamethasone Acetate), 74
Dalalone L.A. (see Dexamethasone Acetate), 74
Danabol (see Methandrostenolone),
78
Danazol, 62
Danocrine (see Danazol), 62
Dapsone, 95
Darapram (see Pyrimethamine),
45
Daraprim (see Pyrimethamine),
45
Daraprime (see Pyrimethamine),
45
DAS (see Anguidine),
15
DAU (see 3-Deazauridine),
18
Daun (see Daunorubicin (HCI)*), 18
Dauno (see Daunorubicin (HCI)*), 18
Daunoblastin (see Daunorubicin (HCf)*), 18
Daunomycin (see Daunorubicin (HCI)*), 18
Daunomycin-HCl
(see Daunorubicin (HCI)*), 18
Daunorubicin (HCI)*, 18
Daunorubicin (liposome encapsulated),
96
Daunorubicin (see Daunorubicin (HCI)*), 18
Daunorubicine (see Daunorubicin (HCI)*), 18
Daunoxone (see Daunorubicin, iiposome encapsulated),
DAVA (see Vindesine Sulfate), 28
DBD (see Dibromodulcitol),
19
DBM (see Dibromomannitol),
19
DCA (see Desoxycorticosterone
Acetate), 74
DCF (see Pentostatin),
65
2'-DCF (see Pentostatin),
65
DCL (see Dichloroallyl lawsone), 19
DCM (see Dichloromethotrexate),
19
DCMTX (see Dichloromethotrexate),
19
DCNU (see Chlorozotocin),
17
DDA (see Dideoxyadenosine),
92
DDC (see Dideoxycytidine),
92
DDC (see Diethyldithiocarbamate),
41
DDI (see Dideoxyinosine),
92
DDMP (see Metoprine),
23
DDP (see Cisplatin*), 17
130
96
Table of Contents
Manuals
D (continued)
DDTC (see Diethyldithiocarbamate),
41
Deacytl-N-methylcolchicine
(see Coicemid),
17
7-Deaza-adenosine
(see Tubercidine),
27
Deazauridine
(see 3-Deazauridine),
18
3-Deazauridine,
18
DEB (see Diethylstilbestrol),
75
DECA (see Dexamethasone),
40, 74
Deca-Durabolin
(see Nandrolone Decanoate),
78
Decaderm (see Dexamethasone),
40, 74
Decadron Tablets (see Dexamethasone),
40, 74
Decadron-LA
Acet (see Dexamethasone
Acetate), 74
Decapeptide
1 (Gosrelin) (see Zoladex (see Gosrelin)),
Decapeptide
1 (see Gosrelin), 77
Decapeptyl,
74
Decaris (see Levamisole HCI*), 64
Decaspray (see Dexamethasone),
40, 74
Decitabine,
18
Decortin (see Desoxycorticosterone
Acetate),
74
Decosterone
(see Desoxycorticosterone
Acetate),
74
Decostrate#
(see Desoxycorticosterone
Acetate),
74
DEDC (see Diethyldithiocarbamate),
41
Deferoxamine,
40
Deflamene (see Formocortal),
77
Defosfamide,
40
Degranol (see Mannomustine),
43
Dehydroemetine,
62
7-Dehydroestrone
(estrogen) (see Equilin), 75
Dehydromethyltestosterone
(see Methandrostenolone),
Deladroxone#
(see Algestone* Acetophenide),
73
Deladumone
(see Estradiol Valerate),
75
Deladumone
(see Testosterone Enanthate),
80
Delalutin#
(see Hydroxyprogesterone
Caproate),
77
Delatestryl (see Testosterone Enanthate),
80
Delcronol (antimetabolite)
(see Metoprine),
23
Delestrogen (see Estradiol Valerate), 75
Delmadinone
Acetate,
74
Delmeson (see Fluorometholone),
76
Delta-9-THC
(see Tetrahydrocannabinol),
46
Delta-Cortef
(see Prednisoione),
79
Delta-Dome#
(see Prednisone),
79
Deltamycin A4 (see Magnamycin),
22
Deitasone (see Prednisone),
79
Deltra (see Prednisone),
79
Deluteval 2X# (see Estradiol Valerate),
75
131
81
78
Table of Contents
Manuals
D (continued)
Deluteval 2X# (see Hydroxyprogesterone Caproate), 77
Demecolcine (see Colcemid), 17
Demecolcine, 17
Demerol (see Meperidine HC1), 43
Demeroi HC1 (see Meperidine HCI), 43
4-Demethoxydaunorubicin (see Idarubiein HCI*), 21
Demethylmisonidazole (see Desmethylmisonidazole), 40
Demulan, component of (see Ethinyl Estradiol), 76
Dendrid (see Idoxuridine*), 42
4'-Deoxyadriamycin hydrochloride (see Deoxydoxorubicin HCI), 18
Deoxycoformycin (see Pentostatin), 65
2'-Deoxycoformycin (see Pentostatin), 65
Deoxydoxorubicin HCI, 18
4'-Deoxydoxorubicin (see Deoxydoxorubicin HCI), 18
Deoxynojirimycin, 92
Deoxyspergualin (HCI), 18
15-Deoxyspergualin trihydrochloride (see Deoxyspergualin HCI), 18
Deoxythioguanosine hydrate (see Alpha-TGdR), 15
Deoxythymidine (see Thymidine), 26
DepAndro 100 (see Testosterone Cypionate), 80
DepAndro 200 (see Testosterone Cypionate), 80
DepGynogen (see Estradiol Cypionate), 75
DepMedalone (see Methylprednisolone Acetate), 78
Depo-ACTH# (see Adrenocorticotropic hormone), 73
Depo-ACTH# (see Corticotropin), 74
Depo-Estradiol (see Estradiol Cypionate), 75
Depo-Medrol (see Methylprednisolone Acetate), 78
Depo-Provera (see Medroxyprogesterone Acetate), 77
Depo-Testadiol (see Estradiol Cypionate), 75
Depo-Testadiol (see Testosterone Cypionate), 80
Depo-Testadiol, component of (see Testosterone Cypionate), 80
Depoepovirin# (see Testosterone Cypionate), 80
DepPredalone (see Prednisolone Acetate), 79
Dermairol (see Tretinoin), 51
Deronil (see Dexamethasone), 40, 74
DES (see Diethylstilbestrol), 75
DES-ME (see Desmethylmisonidazole), 40
Desacetylmethylcolchicine (see Colcemid), 17
Desacetylvinblastine amide sulfate (see Vindesine Sulfate), 28
Descinolone Acetonide#, 74
Desmecolcine (see Coicemid), 17
Desmethylmisonidazole, 40
Desmophosphamide (see Defosfamide), 40
Desoxycorticosterone Acetate, 74
132
Table of Contents
Manuals
D (continued)
Desoxycorticosterone
Pivalate, 74
Detorubicin,
18
Detox, 62
Dexacidin (see Dexamethasone),
40, 74
Dexamethasone
Acetate, 74
Dexamethasone
Dipropionate,
75
Dexamethasone
Sodium Phosphate, 75
Dexamethasone,
40, 74
Dexasone (see Dexamethasone),
40, 74
Dexone (see Dexamethasone),
40, 74
Dexormaplatin,
18
Dexrazoxane,
19
Dezaguanine Mesylate, 19
Dezaquanine,
19
DFMO (HCI) (see DFMO),
19
DFMO (see Eflornithine HCI), 96
DFMO,
19
DHAC,
19
DHAD (see Mitoxantrone (HCI)*), 23
DHAQ (see Mitoxantrone (HCI)*), 23
DHPG (see Ganciclovir),
42, 97
Di-Estryl (see Diethylstilbestrol),
75
Diacetoxyscirpenol
(see Anguidine),
15
Diacetylmorphine
dihydrochloride (see Heroin), 42
Diaminopyritamin
(see Pyrimethamine),
45
3,5-Diamino-s-triazole
(see Guanazole),
21
Diamorphine HCI (see Heroin), 42
Diamox (carbonic anydrase inhibitor) (see Acetazolamide),
Dianabol# (see Methandrostenolone),
78
Dianhydrodulcitol,
19
Dianhydrogalactitol
(see Dianhydroduicitol),
19
Dianoxide Furoate, 96
Diaziquone,
19
Diazoacetylserine
(see Azaserine*#),
16
6-Diazo-5-Oxo-L-Norleucine
(9CI) (see DON), 19
Dibestii# (see Diethylstilbestrol Dipropionate),
75
Dibromannit (see Dibromomannitol),
19
Dibromdulcit (see Dibromodulcitol),
19
Dibromodulcitol,
19
Dibromomannitol,
19
DIC (see Dacarbazine*),
18
Dichloroallyl lawsone, 19
Dichloroamethopterin
(see Dichloromethotrexate),
19
Dichlorolapachol
(see Dichloroallyl lawsone), 19
133
39
Table of Contents
Manuals
D (continued)
DichloroMethotrexate
(see Dichloromethotrexate),
19
Dichloromethotrexate,
19
Dichloromethyl-diethylamine-HCl
(see Mechlorethamine
(HCI)*), 22
Didanosine (see Dideoxyinosine),
92
Didemnin B, 19
Dideoxyadenosine,
92
Dideoxycytidine,
92
2',3'-dideoxycytidine
(see Dideoxycytidine), 92
2',3'-dideoxyinosine
(see Dideoxyinosine),
92
Dideoxyinosine,
92
Dideoxynueleoside (thymidine) analogue (see D4T), 92
Didronel (see Etidronate Disodium), 41
Dienestrol,
75
Diethyldithiocarbamate,
41
Diethylstilbestrol Diphosphate,
75
Diethylstilbestrol Dipropionate,
75
Diethylstilbestrol,
75
Diflucan (see Fluconazole),
41, 97
Diflucortolone* Pivalate, 75
Diflucortolone*,
75
Difluoromethylornithine
(see DFMO), 19
Diglycoaldehyde,
19
Dihematoporphyrin
Ether (see Porfimer Sodium), 24
Dihydro-5-Azacytidine
HCI, 19
5,6-Dihydro-5-azacytidine
hydrochloride (see DHAC), 19
Dihydroazacytidine
(see DHAC), 19
Dihydrolenperone,
19
Dihydroxyanthracenedione
dihydrochloride (see Mitoxantrone (HCI), 23
1,25-Dihydroxy-vitamin D3, 51
Dihydro-lenperone
(see Dihydrolenperone),
19
Dilaudid (analgesic; narcotic) (see Hydroxyzine HCI), 42
Diltiazem HCI, 41
Dimepranol Acedoben, 41
Dimethyl Sulfoxide, 51
Dimethyl-triazeno-imidazole-carboxamide
(see Dacarbazine*),
18
Dimethylbusulfan,
62
Dimethyltestosterone
(see Calusterone),
73
Dimethylurethimine
(see Meturedepa),
23
Dimonidazole,
41
Dinacrin# (see lsoniazid*), 97
Dinitrochlorobenzene,
62
Dinitrofluorobenzene,
62
Diogyn (see Estradiol), 75
Diogyn E (see Ethinyl estradiol), 76
134
Table of Contents
Manuals
D (continued)
Diogynets (see Estradiol),
75
Diphaston (see Dydrogesterone*),
75
Diphenhydramine
HCI, 41
Diphenidol,
41
Diprolene (see Betamethasone
Dipropionate),
73
Diprosone (see Betamethasone
Dipropionate),
73
Dipyridamole,
41
Disai (see Furosemide*),
41
Dispermine (see Piperazine),
44
Disulfiram (see Antabuse),
91
Ditate# (see Estradiol Valerate), 75
Ditate# (see Testosterone
Enanthate),
80
Dithiocarb (see Diethyldithiocarbamate),
41
Ditubin# (see Isoniazid*),
97
Divema (see Pyran copolymer),
65
DL Sarcolysine (see Melphalan* (HCI)), 22
DM (see Dexamethasone),
40, 74
4-DMDR (see Idarubicin HCI*), 21
DMPA (see Medroxyprogesterone
Acetate),
77
DNFB (see Dinitrofluorobenzene),
62
DNM (see Daunorubicin
(HCI)*), 18
DNR (see Daunorubicin
(HCI)*), 18
DOCA (see Desoxycorticosterone
Acetate),
74
Doca acetate# (see Desoxycorticosterone
Acetate), 74
Dolophine HCI (see Methadone HCI), 43
Domestroi (see Diethylstilbestrol),
75
Domperidone,
41
DON, 19
Dopmedrol (see Methylprednisolone),
78
Dorcostrin#
(see Desoxycorticosterone
Acetate),
74
DOXO (see Desoxycorticosterone
Acetate),
74
Doxorubicin (HCI)*, 19
Doxorubicin (liposome-encapsulated),
96
Doxorubicin-DNA
complex, 19
DRB (see Daunorubicin
(HCI)*), 18
Drolban# (see Dromostanolone
Propionate),
75
Dromostanolone
Propionate,
75
Dronabinoi,
96
Droperidol*,
41
Drostanolone
(see Oxymetholone*),
79
Drostanolone
propionate
(see Dromostanolone
Propionate),
Droxone# (see Algestone* Acetophenide),
73
DSM (see Dexamethasone),
40, 74
DT (see Thymidine),
26
135
75
Table of Contents
Manuals
D (continued)
136
Table of Contents
Manuals
E (continued)
Emanil (see Idoxuridine*),
42
Emcyt (see Estramustine
Phosphate Sodium), 76
Emdisterone (see Dromostanolone
Propionate),
75
EMET (see Emetine),
19
Emetin (see Emetine),
19
Emetine monohydrochloride
(see Emetine),
19
Emetine,
19
Emofolin (sodium), 20
EN-1639A (see Naltrexone),
44
Enarax (see Hydroxyzine HC1), 42
Endorphin,
41
Endoxan (see Cyclophosphamide*),
18
Endoxana (see Cyclophosphamide*),
18
Enduxan (see Cyelophosphamide*),
18
Enovid (see Mestranol),
78
Enpromate#,
20
ENT 26079 (see Aminopterin),
15
ENT 50852 (see Altretamine),
15
ENT-50451 (see Benzodepa),
16
ENT-50825 (see Porfiromycin),
25
EO-26 (see 3-Deazauridine),
18
EPEG (see Etoposide*),
20
EPI (see Epirubicin (HCI)), 20
Epidropal (see Allopurinol*),
39
Epipodophyllotoxin
(see Teniposide),
26
Epipodophyliotoxin
ethylidene glucopyranoside
(see Etoposide*)
Epipropidine#,
20
Epirubicin (HCI), 20
EPO (see Erythropoietin),
62, 96
Epodyl (see Ethoglucid),
20
Epoetin Alfa, 62, 96
Epogen (see Erythropoietin),
62, 96
Eponate (see Epipropidine#),
20
Epoxypropidine
(see Epipropidine#),
20
Eprox (see Erythropoietin),
62, 96
EPT (see Teniposide),
26
Equilin, 75
Eraverm (see Piperazine),
44
Erbaprelina (see Pyrimethamine),
45
Ergamisol (see Levamisole HCI*), 64
Erysan (see Chlornaphazine*),.
40
Erythropoietin,
62, 96
Eskalith (see Lithium Carbonate),
43
Eskatrol (see Prochlorperazine*),
45
137
20
Table of Contents
Manuals
E (continued)
Esorubicin HCI (see Deoxydoxorubicin HCI), 18
Estan# (see Dienestrol),
75
Esteed (see Ethinyl estradiol), 76
Estigyn (see Ethinyl estradiol), 76
Estilbin (see Diethylstilbestroi),
75
Estinyl (see Ethinyl estradiol), 76
Eston-E (see Ethinyl estradiol), 76
Estoral (see Ethinyl estradiol), 76
Estrace (see Estradiol), 75
Estracyt (see Estramustine Phosphate Sodium), 76
Estraderm "ITS (see Estradiol), 75
Estradiol Benzoate, 75
Estradiol Cypionate, 75
Estradiol Dipropionate,
75
Estradiol Mustard, 75
Estradiol Valerate, 75
Estradiol, 75
Estradurin (see Polyestradiol phosphate),
79
Estrafon (see Perphenazine),
44
Estramustine phosphate disodium (see Estramustine Phosphate
Estramustine Phosphate Sodium, 76
Estramustine,
75
Estratab (see Estrogens, Esterified), 76
Estratest (see Methyltestosterone),
78
Estratest, (see Estrogens, Esterified), 76
Estrifar (see Hexestrol), 77
Estriol, 76
Estrobene (see Diethylstilbestrol),
75
Estrogens, Conjugated,
76
Estrogens, Esterified, 76
Estronal (see Hexestrol), 77
Estrone, 76
Estropipate,
76
Estrovis (see Quinestrol),
80
Etanidazole,
41
Ethacrynic Acid, 41
Ethambutol HCI, 96
Ethanesulfonic
acid compound (see Baker's antifol), 16
Ethidium chloride, 20
Ethidol (see Ethinyl estradiol), 76
Ethinoral# (see Ethinyi estradiol), 76
Ethinyl Estradiol, 76
Ethiodized Oil*, 41
Ethiodol-131#
(radio-opaque medium) (see Ethiodized Oil*),
138
Sodium),
41
76
Table of Contents
Manuals
E (continued)
Ethiofos# (see Amifostine),
39
Ethionamide,
96
Ethoglucid,
20
Ethyl carbamate#
(see Urethane),
27
9-Ethyl-6-Mercaptopurine,
20
9-Ethyl-6-MP (see 9-Ethyl-6-Mercaptopurine),
Ethylchlorformate,
62
2-ethylhydrazide
(see Mitopodozide),
23
Ethylidine-Lignan-P
(see Etoposide*),
20
Ethynylestrenol
(see Lynestrenol#),
77
Ethyol (see Amifostine),
39
Eticyclin (see Ethinyl estradiol), 76
Eticylol# (see Ethinyl estradiol), 76
Etidronate Disodium, 41
Etinestrol (see Ethinyl estradiol), 76
Etoglucid (see Ethoglucid),
20
Etoposide*,
20
Etoprine,
20
Etrenol (see Hycanthone (mesylate)), 21
Etretinate,
51
Etrosyn (see Diethylstilbestrol),
75
EU-3120 (see Acodazole (HCI)), 15
Eudyna (see Tretinoin),
51
Eulexin (see Flutamide),
77
Euthroid (see Liotrix), 77
Exluton (see Lynestrenol#),
77
Extra-Plex (see Hexestrol),
77
20
F
F3TDR, 20
FAA (see Flavone acetic acid), 20
Fadrazole HCI, 20
Famciclovir, 96
2-FAMP (see Fludarabine
Phosphate),
20
Fansidar, component of (see Pyrimethamine),
45
Fansidar,
41
Farlutin (see Medroxyprogesterone
Acetate),
77
FAS (see 2-Fluoroadenosine#),
20
2 FAS (see 2-Fluoroadenosine#),
20
Fazarabine,
20
5-FC (see Flucytosine),
97
FC 1157a (antiglucocorticoid)
(see Toremifene Citrate),
FCA (see Freund's adjuvant), 62
139
81
Table of Contents
Manuals
F (continued)
Fedibaretta (see Phetharbital),
24
Feldene (anti-inflammatory)
(see Piroxicam), 44
Feminone (see Ethinyl estradiol), 76
Femstat (see Butoconazole),
95
Fenesterin (see Phenesterine),
24
Fenestrin (see Phenesterine),
24
Fenobolin (see Nandrolone Phenpropionate),
79
Fenretinide,
20
Fentanyl Citrate, 41
FIAU 96
Filgrastim (see G-CSF), 97
Filgrastim, 62
Flagyl (see Metronidazole),
98
Flagyl, component of, I.V. RTU (see Metronidazole),
98
Flavone acetic acid, 20
Flavone-8-Acetic
Acid (see Flavone acetic acid), 20
Florafur (see Tegafur), 26
Floridine (see Sodium Fluoride), 45
Florinef Acetate (see Fludrocortisone Acetate), 76
Floxin (see Ofloxacin), 98
Floxuridin (see Floxuridine*), 20
Floxuridine*,
20
FLT (see Fluorothymidine),
92
FLU (see Fluoxymesterone),
76
Fluaid (see Tegafur), 26
Fluconazole,
41, 97
Flucytosine, 97
Fludara (see Fludarabine
Phosphate),
20
Fludarabine
Phosphate,
20
Fluderma (see Formocortai),
77
Fludestrin (see Testolactone*),
80
Fludrocortisone
Acetate, 76
Flumethasone*,
76
2-Fluoroadenine
arabinoside 5-Phosphate (see Fludarabine
2-Fluoroadenosine#,
20
2-Fluoro-ARA AMP (see Fludarabine
Phosphate),
20
Fluorodopan (see Fluorodopane),
20
Fluorodopane,
20
Fluorofur (see Tegafur), 26
Fluorol (see Sodium Fluoride), 45
Fluoromethalone
(see Fluorometholone),
76
Fluorometholone,
76
Fluoroplex (see Fluorouracil*), 20
Fluorothymidine,
92
Fluorouracil*,
20
140
Phosphate),
20
Table of Contents
Manuals
F (continued)
5-Fluorouracil (see Fluorouracil*),
20
5-Fluorouracil deoxyriboside (see Floxuridine*),
20
Fluorpan (see Fluorodopane),
20
Fluosol-DA,
41
Fluotestin (see Fluoxymesterone),
76
Fluoximesterone
(see Fluoxymesterone),
76
Fluoxymesterone,
76
Fluperolone Acetate, 76
Fluprednisolone*
Valerate#,
76
Fiuprednisolone*,
76
Fluracil (see Fluorouracil*),
20
5-Fluracil (see Fluorouracil*),
20
Flurandrenolide,
76
Flurandrenolone#
(see Flurandrenolide),
76
Flurbiprofen,
41
Fluril (see Fluorouracii*),
20
Flurocitabine#,
20
5-Flurodeoxyuridine
(see Fioxuridine*),
20
Flurogestone Acetate, 76
Flusteron (see Fluoxymesterone),
76
Flutamide,
77
Flutestos (see Fluoxymesterone),
76
Flutone# (see Triamcinolone Acetonide),
81
FML Forte (see Fluorometholone),
76
FML Liquifilm (see Fluorometholone),
76
FML S.O.P. (see Fluorometholone),
76
FML-S Liquifilm (see Fluorometholone),
76
Folex (see Methotrexate*),
22
Foligan (see Allopurinol*),
39
Folinic acid (see Leucovorin (calcium*)), 43
Fonatol (see Diethylstilbestrol),
75
Formocortal,
77
Formula 405 (see Pregnenolone*
Succinate),
80
Foscarnet Sodium, 97
Foscavir (see Foscarnet Sodium), 97
Fosfestrol (see Diethylstilbestrol
Diphosphate),
75
Fosquidone,
20
Fostriecin Sodium, 20
Fotemustine,
20
Fourneau 309 (see Suramin Sodium), 26
Freund's adjuvant, 62
FT (see Tegafur),
26
FF-106 (see Doxorubicin (HCI)*), 19
FT-207 (see Tegafur),
26
141
Table of Contents
Manuals
F (continued)
Ftorafur (see Tegafur), 20, 26
FU (see Fluorouracil*),
20
5-FU (see Fluorouracil*),
20
FUDR (see Floxuridine*),
20
5-FUDR (see Floxuridine*),
20
Fungizone (see Amphotericin B), 95
Furacin (see Nitrofurazone),
23
Furazolidone,
97
5-FURD (see Floxuridine*),
20
Furosemide*,
41
Furoxone (see Furazolidone),
97
Futraful (see Tegafur), 26
FVA (see Flavone acetic acid), 20
Fx5 (see Thymosin), 66
FXM (see Fluoxymesterone),
76
G
G-CSF (Granulocyte Colony-Stimulating Factor), 41, 97
G-CSF, 41, 97
Galactitol (see Dianhydrodulcitol),
19
Gallium Nitrate, 62
Gallium trinitrate (see Gallium Nitrate), 62
Gamma Interferon,
97
Gammaguard (see IVIG), 64
Gammaphos (see Amifostine), 39
GAN (see Gallium Nitrate), 62
Ganciclovir, 42, 97
Ganglioside, 62
Ganite (see Gallium Nitrate), 62
Gantanol, component of (see Sulfamethoxazole),
46
Geabol (see Methandrostenolone),
78
Gemcitabine HCI, 21
Gemcitabine,
21
Genoxal (see Cyclophosphamide*),
18
Germanin (see Suramin Sodium), 26
Gestaclone,
77
Gestafortin (see Chlormadinone* Acetate), 73
Gestapuran (see Medroxyprogesterone
Acetate),
77
Gestatron (see Dydrogesterone*),
75
Gesterol 50 (see Progesterone),
80
Gestonorone Caproate, 77
Gestoral LA 250 (see Hydroxyprogesterone
Caproate),
77
Ginestrene (see Ethinyl estradiol), 76
142
Table of Contents
Manuals
G (continued)
GLQ223, 92
Glycidyl isocyanurate (see Teroxirone),
26
Glycine, 42
GM-CSF, 42, 92
GM2 (see Ganglioside),
62
Gold Au 198, 42
Gosrelin,
77
Gotax (see Allopurinol*),
39
GP160 vaccine, 92
GR 38032 F (antagonist) (see Serotonin),
45
GR 38032F (see Ondansetron HCI), 44
GR 63178A, 21
GR 63178K (see Fosquidone),
20
Grafestrol (see Diethylstilbestrol),
75
Granisetron,
42
Granulocyte colony stimulating factor (see G-CSF), 41
Granulocyte macrophage colony stimulating factor (see GM-CSF),
Granulocyte-colony
stimulating factor (see CSF-GM), 40
GRF 38032F (see Ondansetron HCI), 44
Guanazol (see 8-Azaguanine),
15
Guanazole,
21
Guanazolo (see 8-Azaguanine),
15
Guaneran (see Thiamiprine),
26
Guanfacine HCI, 42
Guanfacine,
97
Gynogen L.A. (estrogen) (see Estradiol Valerate),
75
H
H.B.F. 386 (see Cactinomycin),
16
H37Ra (see C-parvum),
62
Haffkinine (see Quinacrine (HCI)), 45
HAL (see Fluoxymesterone),
76
Haldol (see Haloperidol),
42
Haldrone (see Paramethasone*
Acetate),
79
Halodrin (see Ethinyl estradiol), 76
Halodrin (see Fluoxymesterone),
76
Haloperidol,
42
Haloprogesterone,
77
Halotestin (see Fluoxymesterone),
76
HC (see Hydrocortisone),
77
HDA (see Cytarabine HCI), 18
HDARA-C (see Cytarabine HCI), 18
HDC (see Hydrocortisone
Sodium Succinate),
77
143
42
Table of Contents
Manuals
H (continued)
He-PC (see Miltefostine),
23
HEDP (see Rhenium-186),
45
Hematoporphyrin
Derivative, 42
Hemel (see Altretamine),
15
Henkel's compound (see Teroxirone), 26
Hepsulfam, 21
Heptanamide (see Deoxyspergualin (HCI)), 18
1,7-Heptanediylsulfamate
ester (see Hepsulfam),
21
Heroin HCI, 42
Heroin hydrochloride (see Heroin), 42
Heroin, 42
Herpesil (see Idoxuridine*),
42
Herpidu (see Idoxuridine*),
42
Herplex (see Idoxuridine*),
42
Hexa-Betalin (see Pyridixone HCI), 45
Hexadecylphosphocholine
(see Miltefostine),
23
Hexadrol (see Dexamethasone Sodium Phosphate),
75
Hexadrol Elixir (see Dexamethasone),
40, 74
Hexadrol Tablets (see Dexamethasone),
40, 74
Hexahydropyrazine
(see Piperazine), 44
Hexalen (see Altretamine*),
15
Hexamethylene bisacetamide (see HMBA), 51
Hexamethylene
diacetamide (see HMBA), 51
Hexamethylmelamine,
21
Hexanoestrol (see Hexestrol), 77
Hexestrofen (see Hexestrol), 77
Hexestrol, 77
Hexoestrol (see Hexestrol), 77
HH (see Homoharringtonine),
21
Hi-Bestrol (see Diethylstilbestrol),
75
Hidrix (see Hydroxyurea*),
21
HIV immunogen, 92
Hivid (see Dideoxycytidine),
92
HLTV antibody, 62
HMBA, 51
HMD (see Oxymetholone*),
79
HMM (see Altretamine),
15
HMM (see Hexamethylmelamine),
21
HN2 (see Mechlorethamine
(HCi)*), 22
Ho 1/193 (see Triethylenemelamine),
27
Hoe 33258 (see Pibenzimol HCI), 24
Hoe 766 (see Busrelin Acetate), 73
Hoechst No. 33258 (see Pibenzimol HCI), 24
Holoxan 1000 (see Ifosfamide*), 21
144
Table of Contents
Manuals
H (continued)
Homandren (see Methyltestosterone),
78
Homidium chloride (see Ethidium chloride), 20
Homofolic acid (see Emofolin (sodium)), 20
Homoharringtonine,
21
Hormoestrol
(see Hexestrol),
77
Hormonisene
(see Chlorotrianisene),
74
5-HP (see 5-Hydroxypicolinaldehyde
thiosemicarbazone),
21
HPA-23, 93, 94
HPMPC,
97
HPP (see Allopurinol*),
39
4-HPR (see 4-Hydroxyphenyl retinamide),
51
HU (see Hydroxyurea*),
21
Human fibroblast interferon (see Immune RNA), 63
Human fibroblast interferon (see Interferon and interferon inducers), 63
Human Jurkat Tumor Derived (see Interleukin-2),
63
Human leukocyte interferon (see Interferon and interferon inducers), 63
Human lymphoblastoid interferon (BW) (see Interferon Alfa-nl),
63
Humatin (see Paromomycin Sulfate), 98
HUR (see Hydroxyurea*),
21
HXM (see Hexamethylmelamine),
21
Hycamptamine
(see Topotecan HCI), 27
Hycanthone (mesylate),
21
Hycanthone methanesulfonate
(see Hycanthone (mesylate)), 21
Hycanthone monomethanesulfonate
(see Hycanthone (mesylate)),
21
HYD (see Hydroxyurea*),
21
Hydeltra (see Prednisolone),
79
Hydeltra-T.B.A.
(see Prednisolone Tebutate),
79
Hydeltrasol (see Prednisoione Sodium Phosphate),
79
Hydrazine Sulfate, 42
Hydrea (see Hydroxyurea*),
21
Hydreia (see Hydroxyurea*),
21
Hydrocortisone
Acetate, 77
Hydrocortisone
Sodium Phosphate,
77
Hydrocortisone
Sodium Succinate, 77
Hydrocortisone,
77
Hydrocortone
Phosphate (see Hydrocortisone
Sodium Phosphate),
77
Hydrogesterone
(see Dydrogesterone*),
75
Hydromorphone
HCI, 42
4'-Hydroperoxycyclophosphamide,
62
Hydroximic acid (see Hydroxyurea*),
21
Hydroxycarbamide
(see Hydroxyurea*),
21
Hydroxycarbamine
(see Hydroxyurea*),
21
Hydroxychloroquine,
92
14-hydroxydaunomycin
(see Doxorubicin (HCI)*),
19
145
Table of Contents
Manuals
H (continued)
Hydroxyethylidene diphosphonate (see Rhenium-186),
Hydroxylurea (see Hydroxyurea*), 21
4-Hydroxyphenyl retinamide, 51
5-Hydroxypicolinaldehyde
thiosemicarbazone,
21
Hydroxyprogesterone
Caproate, 77
Hydroxyurea*, 21
Hydroxyzine HC1, 42
Hydura (see Hydroxyurea*),
21
Hyperbaric Oxygen, 42
Hypericin, 92
I 131, 63
I 131 Idotope (see Sodium Iodide), 45
I-Dox (see Deoxydoxorubicin HCI), 18
Ibenzmethyzin hydrochloride (see Procarbazine*
Ibiothyron (see Liothyronine Sodium), 77
IBZ (see Procarbazine* (HC1)), 25
ICDT (see Dacarbazine*),
18
ICI 118 (see Gosrelin), 77
ICI 137233 (see Aphidicolin Glycinate), 15
ICI-32865 (see Ethoglucid), 20
ICI-46,474 (see Tamoxifen Citrate), 80
ICI-59118 (see Razoxane), 25
ICIG 1109 (alkylating agent) (see Lomustine*),
ICRF Isomer (see ICRF-187), 21
ICRF-159 (see Razoxane), 25
ICRF-187 (see Dexrazoxane),
19
ICRF-187, 21
ICS-205930 (see Tropisetron),
46
ICT (see Dacarbazine*),
18
IDA (see Idarubicin HCI*), 21
Idamycin (see Idarubicin HCI*), 21
Idarubicin HCI*, 21
Idexur (see Idoxuridine*),
42
Idoxuridin (see Idoxuridine*), 42
Idoxuridine*, 42
IDU (see Idoxuridine*),
42
Idu-Oculos (see Idoxuridine*), 42
Idulea (see ldoxuridine*),
42
IDUR (see Idoxuridine*),
42
5-IUDR (see Idoxuridine*), 42
IdUrd (see Idoxuridine*),
42
45
(HCI)),
21
146
25
Table of Contents
Manuals
I (continued)
Iduridin (see Idoxuridine*),
42
IF (see Interferon and interferon inducers), 63
Ifex (see Ifosfamide*),
21
IFN (see Immune RNA), 63
IFN (see Interferon and interferon inducers),
63
Ifosfamid (see Ifosfamide*),
21
Ifosfamide*,
21
IFX (see Ifosfamide*),
21
IL-2 (see Interleukin-2),
63, 93
IL-2 + IL-4 (Cetus & Sterling) (see Interleukin-2),
64
11-2 Jurkat Derived (see Interleukin-2),
63
IL-2 Recombinant
Interleukin-2 (see Interleukin-2),
63
Ilmofosine,
21
Imexon, 63
IMI 58 (see Deoxydoxorubicin
HCI), 18
IMI-28 (see Epirubicin (HCI)), 20
IMI-30 (see Idarubicin HCI*), 21
Imidazole mustard (see TIC-mustard),
27
Imidazole-l-Acetamide
(see SR 2508), 45
Imididazole carboximide (see TIC-mustard),
27
Imipemide (see Imipenem),
21
Imipenem, 21
Imipenem-Cilastatin,
42, 97
Immune globulin IV, 93
Immune interferon (see Interferon Alfa-n3), 63
Immune RNA, 63
IMPY (see Pyrazolo-Imidazole
compound),
25
Imreg-1, 92
Imunovir (see Isoprinosine),
42
Imuran (see Azathioprine*),
16
Imurek (see Azathioprine*),
16
Imurel (see Azathioprine*),
16
Imuthiol, 92
Imuvert, 63
Inapsine (see Droperidol*),
41
INDI (see Indicine-N-oxide),
21
Indicine-N-oxide,
21
Indocin (anti-inflammatory
(see Indomethacin*),
42
Indomethacin*,
42
Inestra (see Ethinyl estradiol), 76
Inflamase (see Prednisolone Sodium Phosphate),
79
INH (see Isoniazid*),
97
INO (see Indicine-N-oxide),
21
Inosine, 42
147
Table of Contents
Manuals
I (continued)
Inosine dialdehyde (see Diglycoaldehyde),
19
5'-Inosinic acid polymers, 65
INOX (see Diglycoaldehyde),
19
Inprochone (see Inproquone),
21
Inproquone,
21
Interferon Alfa-2a, 63
Interferon Alfa-2b, 63
Interferon Alfa-nl, 63
Interferon Alfa-n3, 63
Interferon and interferon inducers, 63
Interferon Gamma-lb,
63
Interleukin,
64
Interleukin-1 alpha (see Interleukin-1),
63
Interleukin-1 beta (see Interleukin-1),
63
Interleukin-1,
63
Interleukin-2 Fusion Toxin, 93
Interleukin-2 liposome, 64
Interleukin-2,
63, 92
Interleukin-4,
64
Interleukin-6,
64
Intron A (see Interferon Alfa-2b), 63
Iododeoxyuridine (see Idoxuridine*), 42
Iodoquinol, 97
IPA (see Riboprine*),
25
Iphosphamid (see Ifosfamide*), 21
lphosphamide (see Ifosfamide*), 21
Ipomeanol, 64
4-Ipomeanol (see Ipomeanol), 64
IPP (see Ifosfamide*), 21
Iproplatin, 21
Ismipur (see Mercaptopurine*),
22
Isoendoxan (see Ifosfamide*), 21
Isofosfamide (see Ifosfamide*), 21
Isolyn# (see Isoniazid*), 97
Isoniazid*, 97
Isophosphamide (see Ifosfamide*), 21
Isopregnenone
(see Dydrogesterone),
75
Isoprinosine, component of (see Dimepranol Acedoben),
Isoprinosine, component of (see Inosine), 42
Isoprinosine,
42, 97
Isopropamide Iodide, 42
Isoptin (see Verapamil (HCI)*), 46
Isoptin hydrochloride (see Verapamil (HCI)*), 46
Isotretinoin* (see Retinoic acid), 51
148
41
Table of Contents
Manuals
I (continued)
Italchine (see Quinacrine (HCi)), 45
ITG (see Thiamiprine),
26
Itraconazole,
42, 97
ITZ (see Itraconazole),
42, 97
IUdR (see Idoxuridine*),
42
IVIG, 64, 97
Izoptin (see Verapamil (HCI)*), 46
J
JB-11, 21
JM-8 (see Carboplatin*),
17
JM-9 (see Iproplatin),
21
Joacamine (see Busulfan*),
16
Joddeoxyuridin
(see Idoxuridine*),
42
K
K Predne-Dome#
(see Prednisolone),
79
Karminomitsin (see Carubicin (HCI)), 17
Karminomycin HC1 (see Chiorambucil*),
17
Kenacort (see Triamcinolone),
81
Kenacort Diacetate syrup (see Triamcinolone
Diacetate),
Kenalog (see Triamcinolone
Acetonide),
81
Kerecid (see Idoxuridine*),
42
Ketoconazole,
77, 97
Ketorolac Tromethamine,
42
Ketrax (see Levamisole HCI*), 64
Khlortrianizen
(see Chlorotrianisene),
74
Kolchamin (see Colcemid),
17
Kolkamin (see Colcemid),
17
Komed, component of (see Sodium Thiosulfate),
45
Kymarabine (see Fazarabine),
20
L
L-3428 (see Amiodarone),
39
L-5103 (see Rifampin),
25
L-693,989, 97
L-69739, 93
L-697661, 93
L-Alanosine (see Alanosine),
15
L-ASE (see (Escherichia coli)), 61
149
81
Table of Contents
Manuals
L (continued)
L-ASE (see Asparaginase), 61
L-ASP (see Asparaginase), 61
L-Asparaginase (see Asparaginase), 61
L-Asparagine amidohydrolase (see Asparaginase), 61
L-Buthionine sulfoximine (see BSO), 42
L-Leucovorin, 43
L-PAM (see Melphalan* (HCi)), 22
L-Phenylalanine mustard (see Melphalan* (HCI)), 22
L-Sarcolysin (see Melphalan* (HC1)), 22
L-Serine diazo-acetate ester (see Azaserine*#), 16
L-Tetramisole HCL (see Levamisole HCI*), 64
Ladakamycin (see Azacitidine), 51
LAK cells, 64
Lamivudine (see 3TC), 94
Laniazid (see Isoniazid), 97
Lasix (see Furosemide*), 41
LB-502 (diuretic) (see Furosemide*), 41
LCR (see Vincristine* Sulfate), 28
Lederfoline (see Leucovorin (calcium)*), 43
Lentinan, 64, 93
Leo 114 (see Polyestradiol phosphate), 79
Leo 275 (see Estramustine), 75
Letrazuril, 98
Leucomycin (see Spiramycin), 45
Leucovorin (calcium)*, 43
Leukaemomycin C (see Daunorubicin (HCI)*), 18
Leukeran (see Chlorambucil*), 17
Leukerin (see Mercaptopurine*), 22
Leukersan (see Chlorambucil*), 17
Leukine (see GM-CSF), 97
Leukine (see Sargramostim), 66
Leukoran (see Chlorambucil*), 17
Leunase (see Asparaginase), 61
Leuprolide Acetate, 77
Leuprorelin (see Leuprolide Acetate), 77
Leupurin (see Mercaptopurine*), 22
Leurocristine sulfate (see Vincristine* Sulfate), 28
Leurosidine sulfate (see Vinrosidine Sulfate#), 28
Leurosine (see Vinleurosine Sulfate#), 28
Leustatin (see 2-CdA), 17
LEV (see Levamisole HCI*), 64
Levamisole HCI*, 64
Levlen (see Ethinyl estradioi), 76
Levomysol HCL (see Levamisole HCI*), 64
150
Table of Contents
Manuals
L (continued)
Levothroid (see Levothyroxine Sodium), 77
Levothyroxine Sodium, 77
Lidocaine, 43
Lidomantle-HC,
component of (see Lidocaine),
43
Linestrenol (see Lynestrenol#),
77
Linfilizin (see Chlorambucil*),
17
Linfolysin (see Chiorambucil*),
17
Liothyronine Sodium, 77
Liotrix, 77
Lipo-Lutin#
(see Progesterone),
80
Liposome-Doxorubicin
Kit, 21
Liquifilm (see Idoxuridine*),
42
Litaler (see Hydroxyurea*),
21
Litalir (see Hydroxyurea*),
21
Lithane (see Lithium Carbonate),
43
Lithium Carbonate,
43
Lithobid (see Lithium Carbonate),
43
Lithonate (see Lithium Carbonate),
43
Lithotabs (see Lithium Carbonate),
43
Lo/Ovral (see Ethinyl estradiol), 76
Loestrin (see Ethinyl estradiol), 76
Lometrexol Sodium, 21
Lomidine (see Pentamidine),
98
Lomustine*,
21
Lonidamine,
43
Lopurin (see Allopurinol*),
39
Lorazepam,
43
Lormin (see Chlormadinone*
Acetate), 73
Lotrimax, component of (see Clotrimazole),
96
Lotrimin (see Clotrimazole),
96
Lotrisone (see Betamethasone
Dipropionate),
73
Lotrisone, component of (see Clotrimazole),
96
Lovastatin,
21
Lowers blood (see Indomethacin*),
42
Loxoribine,
43
Lumbrical (see Piperazine),
44
Lupron Depot (TAP) (see Leuprolide Acetate),
77
Lupron TAP (see Leuprolide Acetate),
77
Lutinyl (see Chlormadinone*
Acetate), 73
Lutopolar (see Medroxyprogesterone
Acetate),
77
Lutoral, (see Medroxyprogesterone
Acetate),
77
LY 119863 (see Vinepidine Sulfate), 28
LY 186641 (see Sulofenur), 26
LY 264618 disodium (see Lometrexol Sodium), 21
151
Table of Contents
Manuals
L (continued)
LY 28002 (see Epipropidine#),
20
LY-099094 (see Vindesine Sulfate), 28
LY-104208 (see Vinzolidine Sulfate), 28
LY188011 (see Gemcitabine),
21
LY188011 hydrochloride (see Gemcitabine HCI), 21
Lymphochin (see Aniline mustard), 15
Lymphocin (see Aniline mustard), 15
Lymphokine activated killer cells (see LAK cells), 64
Lymphoquin (see Aniline mustard), 15
Lynestrenol#,
77
Lynoral# (see Ethinyl estradiol), 76
Lysodren (see Mitotane*),
23
M
M-9500 (see Triethylenemelamine),
27
M-AMSA (see Amsacrine), 15
M-Azido-Pyrimethamine
Ethane Sulphonate,
21
MA (see Methandrostenolone),
78
Mablin (see Busulfan*),
16
Mafosfamide L-lysine (see Mafosfamide), 22
Mafosfamide, 21
Magnamycin A (see Magnamycin), 22
Magnamycin, 22
Magnesium Sulfate, 43
Malathion, 98
Malestrone (see Methyltestosterone),
78
Malocide (see Pyrimethamine),
45, 99
Mannit-Lost (see Mannomustine),
43
Mannit-Mustard (see Mannomustine),
43
Mannitol Mustard (see Mannomustine),
43
Mannitol, 43
Mannomustine,
43
Mannosulfan,
22
MAP (see Medroxyprogesterone
Acetate),
77
Marax (see Hydroxyzine HC1), 42
Marcellomycin, 22
Marinol (see Dronabinol, Tetrahydrocannabinol),
46, 96
Masoprocol, 22
Masterid (see Dromostanolone
Propionate),
75
Masteril (see Dromostanolone
Propionate),
75
Masterone (see Dromostanolone
Propionate),
75
Matrol (see Chlormadinone* Acetate), 73
Matulane (see Procarbazine* (HCI)), 25
152
Table of Contents
Manuals
M (continued)
Maxidex (see Dexamethasone),
40, 74
Maxitrol (see Dexamethasone),
40, 74
Maytansine,
22
MBBA (see Cytembena),
18
MCCNU (see Semustine),
25
McN-JR-1625 (see Haloperidol),
42
McN-JR-4749 (see Droperidol*),
41
MeN-R-1967 (see Fenretinide),
20
MCNU (see Semustine),
25
MCP (see Metoclopramide
(HCI)*), 43
MDL 28574, 93
MDL 71,782A (see Eflornithine HCI), 19
MDL-72222,
43
MDL-73147EF,
43
Mebryl (Czechoslovakia)
(see Cytembena),
18
MeCCNU (see Semustine),
25
Mechlorethamine
(HCI)*, 22
Mechlorethamine
(see Mechlorethamine
(HCI)*), 22
Medrate (see Methylprednisolone),
78
Medrocort#
(see Medrysone*),
77
Medrogestone,
77
Medrol (see Methylprednisolone),
78
Medrol Stabisol# (see Methylprednisolone
Sodium Phosphate),
Medrone (see Methylprednisolone),
78
Medrotestron
(see Oxymetholone*),
79
Medroxyprogesterone
Acetate,
77
Medrysone*,
77
MeG (see Methyl-G),
22
Meg-CSF, 64
Megace (see Megestrol Acetate), 78, 98
MeGAG (see Methyl-G), 22
Megestrol Acetate, 78, 98
Melbex# (see Mycophenolic acid), 51
Melengestrol Acetate,
78
Melfalan (see Melphalan* (HCI)), 22
Melphalan* (HCI), 22
MEN (see Menogaril),
22
Menest (see Estrogens, Esterified), 76
Menogaril, 22
Menolyn (see Ethinyl estradiol), 76
Menrium, component of (see Estrogens, Esterified),
76
Mepacrine (see Quinacrine (HCI)), 45
Mepadin (see Meperidine HC1), 43
Meperga (see Meperidine HC1), 43
153
78
Table of Contents
Manuals
M (continued)
Mepergan, component of (see Promethazine HCI*), 45
Meperidine HCI, 43
Meprednisone*,
78
MER (see BCG), 61
Meractinomycin (see Dactinomycin*),
18
Merbarone, 22
Merbentul (see Chlorotrianisene),
74
Mercaleukin (see Mercaptopurine*),
22
Mercaptopurine*,
22
6-Mercaptoguanine
(see Thioguanine*),
26
6-Mercaptoinosine
(see 6-Mercaptopurine riboside), 22
6-Mercaptopurin
(see Mercaptopurine*),
22
6-Mercaptopurine
(see Mercaptopurine*),
22
6-Mercaptopurine
ribonucleoside (see 6-Mercaptopurine
riboside), 22
6-Mercaptopurine
riboside, 22
Mercapurin (see Mercaptopurine*),
22
Mern (see Mercaptopurine*),
22
Mertestate#
(see Testosterone),
80
Mesna*, 43
Mesnex (uromitexan) (see Mesna*), 43
Mesnum (see Mesna*), 43
Meso-NDGA (see Masoprocol), 22
Mespergan (see Methadone HCI), 43
Mesterolone,
78
Mestranol, 78
Metace (see Chlorotrianisene),
74
Metanabol (see Methandrostenolone),
78
Metandienon (see Methandrostenolone),
78
Metandren (see Methyltestosterone),
78
Metandrostenolone
(see Methandrostenolone),
78
Metasoi (see Methandrostenolone),
78
Methadone HCI, 43
Methadose (analgesic; narcotic) (see Methadone HCI), 43
Methandronolone
(see Methandrostenolone),
78
Methandrostenolone,
78
Methanol extracted residual of BCG (see BCG), 61
MeTHHF (see Emofolin (sodium)), 20
Methionyl Interferon Consensus, 65
Metholone (see Oxymetholone*),
79
Methosarb#
(see Calusterone),
73
Methotrexate sodium (see Methotrexate*),
22
Methotrexate*,
22
Methoxsalen,
43
Methral (see Fluperolone Acetate), 76
154
Table of Contents
Manuals
M (continued)
Methyl CCNU (see Semustine), 25
Methyl ether (see TMCA), 27
Methyl methanesulfonate
(see Methyl methanesulphonate),
22
Methyl methanesulphonate,
22
Methyl streptonigrin (see Streptonigrin),
25
Methyl-G,
22
Methyl-GAG
(see Methyl-G), 22
6-Methyl MP-riboside (see 6-Methylmercaptopurine
riboside), 23
Methylcyclohexyl nitrosourea (see Semustine),
25
5-Methyldeoxyuridine
(see Thymidine), 26
Methylene Dimethane Sulfonate, 22
Methylformamide
(see N-Methylformamide),
51
Methylglyoxal bisguanyl-hydrazone
dihydrochloride
monohydrate,
22
Methylhydrazine
(see Procarbazine* (HCI)), 25
6-Methylmercaptopurine
riboside, 23
Methylmethane
sulfonate (see Methyl methanesulphonate),
22
Methylphenidate,
43
Methylprednisolone,
78
Methylprednisolone
Acetate, 78
Methyiprednisolone
Sodium Phosphate,
78
Methylprednisolone
Sodium Succinate, 78
Methyltestosterone,
78
5-Methyltetrahydrohomofolate
disodium (see Emofolin (sodium)),
20
Methylthioinosine
(see 6-Methylmercaptopurine
riboside), 23
6-Methylthiopurine
riboside (see 6-Methylmercaptopurine
riboside), 23
Methynodiol Diacetate#,
78
Meti-Derm (see Prednisolone),
79
Meticortelone
acetate (see Prednisolone Acetate),
79
Meticortelone
Soluble (see Prednisolone Hemisuccinate),
79
Meticorten (see Prednisone),
79
Metoclopramide
(HCI)*, 43
Metoprine,
23
Metreton (see Prednisolone Sodium Phosphate),
79
Metro I.V. (see Metronidazole),
98
Metrone (see Methyltestosterone),
78
Metronidazole,
98
Meturedepa,
23
Metyrosine,
44
Mevacor (see Lovastatin),
21
Mevinolin#
(see Lovastatin), 21
Mexate (see Methotrexate*),
22
Mexate AQ (see Methotrexate*),
22
Mexiletine HC1, 98
Mexitil (see Mexiletine HCI), 98
155
Table of Contents
Manuals
M (continued)
MGA (see Melengestrol Acetate), 78
MGA (see Methyl-G), 22
MGBG (see Methyl-G), 22
MGGH (see Methyl-G), 22
Miboleron (see Mibolerone),
78
Mibolerone,
78
Micatin (see Miconazole), 98
Miconazole, 98
MicrofoUin (see Ethinyl estradiol), 76
Midazolam HCI, 44
Mielobromol (see Dibromomannitol),
19
Mifepristone,
78
MIH (see Procarbazine* (HCI)), 25
Milprem (see Estrogens, Conjugated), 76
Miltefostine,
23
Milurit (see Allopurinol*),
39
Mintezol (see Thiabendazole),
100
Misonidazole,
44
Mistabron (see Mesna*), 43
Misulban (see Busulfan*),
16
MITC (see Mitomycin*), 23
Mitexan (see Mesna*), 43
MITH (see Plicamycin*), 24
Mithracin (see Plicamycin*), 24
Mithramycin# (see Plicamycin*), 24
Mitindomide,
23
Mito (see Mitomycin*), 23
MITO-C (see Mitomycin*), 23
Mitobronitol (see Dibromomannitol),
19
Mitocarcin, 23
Mitocin-C (see Mitomycin*), 23
Mitociomine, 23
Mitocromin, 23
Mitogillin, 23
Mitoguazone (see Methyl-G), 22
Mitoguazone dihydrochloride (see Methyl-G),
Mitolac (see Dibromodulcitol),
19
Mitolactol (see Dibromodulcitol),
19
Mitomalcin, 23
Mitomycin-C (see Mitomycin*), 23
Mitomycin*, 23
Mitopodozide,
23
Mitosper, 23
Mitostan (see Busulfan*), 16
22
156
Table of Contents
Manuals
M (continued)
Mitotan (see Mitotane*),
23
Mitotane*,
23
Mitoxana (see Ifosfamide*),
21
Mitoxantrone (HC1)*, 23
Mitozolomide,
23
MJF 9325 (see Ifosfamide*),
21
MJF-12264, (see Tegafur), 26
MK-217 (see Alendronate
Sodium), 39
MK-595 (diuretic) (see Ethacrynic Acid), 41
1-MM (see Puromycin (HCI)), 25
MMC (see Mitomycin*),
23
6-MMPR (see 6-Methylmercaptopurine
riboside), 23
MN rgpl20/HIV-1,
93
MNI (see Misonidazole),
44
Modicon (see Ethinyl estradiol), 76
Modrenal (see Trilostane),
81
Molybdenum,
44
Monistat (see Miconazole),
98
Monocional Antibody,
65
Monomethylformamide
(see N-Methylformamide),
51
8-MOP (see Methoxsalen),
43
Mopidamol,
23
Moranyl (see Suramin Sodium), 26
Morphine Sulfate, 44
MP (see Mercaptopurine*),
22
6-MP (see Mercaptopurine*),
22
MPA (see Medroxyprogesterone
Acetate),
77
MPL (see Melphalan* (HCI)), 22
6-MPR (see 6-Mercaptopurine
riboside), 22
MS Contine (see Morphine Sulfate), 44
MSI (see Morphine Sulfate), 44
MSL-109, 98
MTC (see Mitomycin*),
23
MTH (see Piicamycin*), 24
MTP-PE (see CGP 19835A), 62
MTS (see Maytansine),
22
MTX (see Methotrexate*),
22
Mucofluid (see Mesna*), 43
Mucopirocin,
98
Muran (see Azathioprine*),
16
Mustard (see Chlornaphazine*),
40
Mustargen (see Mechlorethamine
(HCI)*), 22
Mustargen-HC!
(see Mechlorethamine
(HCI)*), 22
Mustine (see Mechlorethamine
(HCI)*), 22
157
Table of Contents
Manuals
M (continued)
Mutamycin (see Mitomycin*), 23
MVE-2, 65
Myagen# (see Bolasterone#),
73
Mycelex (see Clotrimazole),
96
Mycelex G (see Clotrimazole),
96
Myco-Triacet II (see Triamcinolone Acetonide),
81
Myco-Triacet II, component of (see Nystatin), 98
Mycobutin (see Rifabutin), 99
Mycolog II (see Triamcinolone Acetonide),
81
Mycolog II, component of (see Nystatin), 98
Mycophenolic acid, 51
Mycostatin (see Nystatin), 98
Myebrol (see Dibromomannitol),
19
Myelobromol (see Dibromomannitol),
19
Myelosan (see Busulfan*),
16
Mylecytan (see Busulfan*),
16
Myleran (see Busulfan*),
16
Mylosar (see Azacitidine),
51
Myristic acid analogs, 93
Mysteclin-F#, component of (see Amphotericin B), 95
Mytrex (see Triamcinolone Acetonide),
81
Mytrex, component of (see Nystatin), 98
N
N-137 (see Carbetimer),
17
N-acetyl cysteine (see NAC), 93
N-Acetyl DON (see Duazomycin),
19
N-butyl-DNJ (see Deoxynojirimycin),
92
N-CWS (see Nocardia rubra), 65
N-CWS, 65
N-Methylformamide,
51
N-Methylmitomycin
C (see Porfiromycin), 25
N-Phenylbarbitol
(see Phetharbital),
24
N-Phosphonacetyl-L-Aspartate
disodium (see PAl.A),
N2 Transduced TIL, 65
N2-TIL/ADA Gene, 65
Nabilone, 44
NAC, 93
Nafarelin Acetate, 78
Nafazatrom,
23
Nafidimide, 23
NAFO (see Nafoxidine HCL), 78
Nafoxidine HCL, 78
158
24
Table of Contents
Manuals
N (continued)
Nafticlorina (see Chlornaphazine*),
40
Naganin (see Suramin Sodium), 26
Naganol HC1 (see Suramin Sodium), 26
Naloxone,
44
Naltrexone,
44
Nalutron#
(see Progesterone),
80
Nandrobolic
(see Nandrolone Phenpropionate),
79
Nandrobolic
L.A.# (see Nandrolone Deeanoate),
78
Nandrolone Decanoate,
78
Nandrolone Phenpropionate,
79
Nandrolone phenylpropionate
(see Nandrolone Phenpropionate),
79
Naphthylamine
(see Chlornaphazine*),
40
Naphuride Sodium (see Suramin Sodium), 26
Naposim (see Methandrostenolone),
78
Naprosyn (see Naproxen),
44
Naproxen,
44
NASH; BSH (radioactive agent) (see Borocaptate
Sodium B 10), 39
Natulan (see Procarbazine* (HCI)), 25
Navelbine (see Vinorelbine),
28
Naxamide# (see Ifosfamide*), 21
NCNU (see Pentamustine),
24
NCO (see Diethylstilbestrol),
75
NCS (see Zinostatin),
28
NDC 0015-3010 (see Bleomycin Sulfate), 16
NDC-0082-4155
(see Daunorubicin (HCI)*), 18
2'NDG (see Ganciclovir),
97
NDHT (see Dromostanolone
Propionate),
75
NebuPent (see Pentamidine),
98
Nedrotestron
propionate (see Dromostanolone
Propionate),
75
Neo-Hombreol-M#
(see Methyltestosterone),
78
Neo-Medrol (see Methylprednisolone
Acetate),
78
Neo-Ormonal
(see Fluoxymesterone),
76
Neo-Oxylone#
(see Fluorometholone),
76
Neocarcinostatin
(see Zinostatin),
28
Neocarzinostatin#
(see Zinostatin),
28
NeoDecadron
(see Dexamethasone
Sodium Phosphate),
75
Neodrol (see Stanolone),
80
Neoplatin (see Cisplatin*),
17
Neosar (see Cyclophosphamide*),
18
Neosone, component of (see Cortisone Acetate),
74
Neovitamin A acid (see Retinoic acid), 51
Nerobil (see Nandrolone Phenpropionate),
79
Nerobol (see Methandrostenolone),
78
Neupogen (see Filgrastim), 62, 97
159
Table of Contents
Manuals
N (continued)
Neupogen (see G-CSF), 62, 97
NFX (see Nafoxidine HCL), 78
NH2 (see Mechlorethamine
(HCI)*), 22
NH2 Nitrogen Mustard (see Mechlorethamine
(HCI)*), 22
NH2-HCI (see Mechlorethamine
(HC1)*), 22
Niac (see Niacin), 44
Niacin, 44
Nicobid (see Niacin), 44
Nicolar (see Niacin), 44
Niconyl# (see Isoniazid*), 97
Nicroest (see Diethylstilbestrol),
75
Nidaton# (see Isoniazid*), 97
Nifedipine, 44
Niftholid (see Flutamide), 77
Niftolid (see Flutamide), 77
Nigrin (see Streptonigrin),
25
Nilestrol (see Diethylstilbestrol),
75
Nilstat (see Nystatin), 98
Nilutamide, 79
Nimodipine, 98
Nimotop (see Nimodipine), 98
Nipent (see Pentostatin),
65
4-Nitroestrone,
79
Nitrofurazone,
23
Nitrogen mustard (see Melphalan* (HCI)), 22
Nitromifene Citrate, 79
Nivazol, 79
Nizoral (see Ketoconazole),
77
NK 631 (see Peplomycin Sulfate), 24
NMF (see N-Methylformamide),
51
Nocardia rubra, 65
Nocodazole (Belgium), 23
Nogalamycin#,
23
Nolvadex (see Tamoxifen Citrate), 80
Nordette (see Ethinyi estradiol), 76
Norethandrolone,
79
Norethin 1/50 M (see Mestranol), 78
Norethrin 1/35E (see Ethinyl estradiol), 76
Norinyl (see Mestranol), 78
Norlestrin (see Ethinyl estradioi), 76
Norquen (see Mestranol), 78
Nortestosterone
phenylpropionate,
(see Nandrolone Phenpropionate),
Nortriptyline HCI, 44
Novantrone (see Mitoxantrone (HCI)*), 23
160
79
Table of Contents
Manuals
N (continued)
Novatrone,
23
Novestrol (see Ethinyl estradiol), 76
Novidium chloride (see Ethidium chloride), 20
NPP (see Nandrolone Phenpropionate),
79
NTPP (see Nandrolone Phenpropionate),
79
Nydrazid (see Isoniazid*), 97
Nylestriol, 79
Nystatin, 98
Nystex (see Nystatin), 98
NZS (see Zinostatin),
28
O
O.p'-DDD (see Mitotane*),
23
O.p'-DDE (see Mitotane*),
23
Octamide PFS (see Metoclopramide (HCI)*), 43
Octreotide Acetate, 65
Oestrogenine
(see Diethylstilbestrol),
75
Ofloxacin, 98
Ogen (see Estropipate),
76
OK-432, 65
Oligomycin B (antibiotic) (see Peliomycin), 24
Omain (see Colcemid),
17
Omaine (see Colcemid),
17
7-OMEN (see Menogaril),
22
Onco-Carbide
(see Hydroxyurea*),
21
Oncostatin K (see Dactinomycin*),
18
Oncotepa (see Thiotepa*),
26
Oncotiotepa
(see Thiotepa*),
26
Oncovin (see Vincristine*
Sulfate), 28
Ondanserin (see Ondansetron HCI), 44
Ondansetron
HCI, 44
Ophthalmadine
(see Idoxuridine*),
42
Optimyd (see Prednisolone Sodium Phosphate),
79
Ora-Testryl (see Oxymetholone*),
79
Ora-Testryl#
(see Fluoxymesterone),
76
Oracil (see Fluorouracil*),
20
Oradiol (see Ethinyl estradiol), 76
Oragest (see Medroxyprogesterone
Acetate),
77
Oralsterone (see Fluoxymesterone),
76
Orange Crush# (anthracene derivative ) (see Bisantrene
Orasone (see Prednisone),
79
Oratestin (see Fluoxymesterone),
76
Orestralyn (see Ethinyl estradiol), 76
161
(HCI)),
16
Table of Contents
Manuals
0 (continued)
Oreton (see Methyltestosterone),
78
Oreton# (see Testosterone),
80
Org 485-50 (see Lynestrenol#),
77
Orgametril# (see Lynestrenol#),
77
Orgametrol (see Lynestrenol#),
77
Ormaplatin (see Tetraplatin),
26
Ormaplatin, 23
Ornidyl (see Eflornithine HCI), 19, 96
Ortho-Cyclen (see Estropipate),
76
Ortho-Novum (see Mestranol), 78
OTC, 93
Ovid (see Malathion), 98
Ovocyclin dipropionate#
(see Estradiol Dipropionate),
Ovoresta M (progestin) (see Lynestrenol#),
77
Ovulen (see Mestranol), 78
Oxandrolone*,
79
Oxanthrazole (see Piroxantrone HCI), 24
Oxantrazole HCI (see Piroxantrone HCI), 24
Oxisuran*#,
23
Oxsoralen (see Methoxsalen),
43
Oxyione# (see Fluorometholone),
76
Oxymetholone*,
79
Oxytocin, 79
Oxyurea (see Hydroxyurea*),
21
75
P
P-165 (antimetabolite)
(see Azaserine*#),
16
P-1742 (glucocorticoid) (see Fluperolone Acetate),
P-2647 (anti-emetic) (see Benzquinamide),
39
P-638 (see Puromycin (HCI)), 25
PA-144 (see Plicamycin*), 24
Paclitaxel, 24
PALA,
24
Palonyl Perovex (see Ethinyl estradiol), 76
PAM (see Melphalan* (HCI)), 22
Pamelor (see Nortriptyline HCI), 44
Pamidronate Disodium, 44
Pancratistatin,
24
Panwarfin (anticoagulant) (see Warfarin Sodium*),
Papaverine HCI, 44
Para-aminosalicylic acid, 98
Paracort# (see Prednisone),
79
Paracortol# (see Prednisolone),
79
162
76
46
Table of Contents
Manuals
P (continued)
Paramethasone*
Acetate, 79
Paraplatin (see Carboplatin*),
17
Paromomycin Sulfate, 98
PAS (see Para-aminosalicylic
acid), 98
Pathocidin (see 8-Azaguanine),
15
Pathocidine (see 8-Azaguanine),
15
Pavabid (see Papaverine Disodium), 44
PCB (see Procarbazine*
(HCI)), 25
PCH (see Procarbazine*
(HCI)), 25
PCI (see Procarbazine*
(HCI)), 25
PCNU, 24
PCZ (see Procarbazine*
(HCI)), 25
PD 90,695-73 (see Dezaguanine Mesylate),
19
PDA (see Phosphoramide
mustard#),
24
PDN (see Prednisone),
79
Pediapred (see Prednisolone Sodium Phosphate),
79
PEG (see Polyethylene Glycol), 44
PEG-IL-2,
65, 93
Pegaspargase,
65
Peliomycin, 24
Penberol,
24
Penclomidine,
24
Pentam 300 (see Pentamidine Iscthionate),
93
Pentam 300 (see Pentamidine),
98
Pentamethylmelamine
HCI, 24
Pentamidine Isethionate,
93
Pentamidine,
98
Pentamustine,
24
Pentosan Polysulfate Sodium, 24
Pentosan sulfate (see Pentosan Polysulfate Sodium), 24
Pentostatin,
65
Pentoxifylline,
44
Pepleomycin (see Peplomycin Sulfate), 24
Peplomycin Sulfate, 24
Peptide T, 93, 99
Peptochemio,
24
Percorten acetate# (see Desoxycorticosterone
Acetate), 74
Percorten pivalate# (see Desoxycorticosterone
Pivalate), 74
Percotol (see Desoxycorticosterone
Acetate),
74
Pergantene (see Sodium Fluoride), 45
Peridex, 99
Perlutex (see Medroxyprogesterone
Acetate),
77
Permastril (see Dromostanolone
Propionate),
75
Permethrin,
99
163
Table of Contents
Manuals
P (continued)
Persantine (see Dipyridamole),
41
Persistol (see Triethylenemelamine),
27
Peyrone's chloride (see Cisplatin*), 17
PFA (see Foscarnet Sodium), 97
Pharmorubicin (see Epirubicin (HCI)), 20
Phenergan (see Promethazine HCI*), 45
Phenergan-D, component of (see Promethazine HCI), 45
Phenergan VC, component of (see Promethazine HCI), 45
Phenesterin (see Phenesterine),
24
Phenesterine,
24
Phenestrin (see Phenesterine),
24
Phenidiemal (see Phetharbital),
24
Phenobolin (see Nandrolone Phenpropionate),
79
Phenyl acetate, 51
Phetharbital,
24
Phosphamide (see Phosphoramide mustard#),
24
Phosphocol P 32 (see Chromic Phosphate P 32), 74
Phosphoramide mustard#, 24
Photofrin (see Porfimer Sodium), 24
Photofrin II (see Porfimer Sodium), 24
Phyllanthoside,
24
Pibenzimol HCI, 24
PIBR (see Pipobroman*),
24
Pimonidazole (see Ro-03-8799), 45
Piperazidine (see Piperazine), 44
Piperazin (see Piperazine), 44
Piperazine estrone sulfate# (see Estropipate), 76
Piperazine, 44
Piperazinedione compound, 24
Pipersol (see Piperazine), 44
Pipobroman*,
24
Piposulfan, 24
Pirazofurin (see Pyrazofurin#),
25
Pirimecidan (see Pyrimethamine), 45
Pirimetamina (see Pyrimethamine), 45
Piritrexim Isethionate,
99
Piroxantrone HCI, 24
Piroxicam, 44
PISU (see Piposulfan),
24
Pitocin (see Oxytocin), 79
Plaquenil Sulfate (see Hydroxychloroquine Sulfate), 92
Platelet Factor 4, 99
Platinex (see Cisplatin*), 17
Platinol (see Cisplatin*), 17
164
Table of Contents
Manuals
P (continued)
Platinum (miscellaneous
agent) (see Cisplatin*),
17
Platinum complex (9CI) (see Iproplatin),
21
Plicamycin*, 24
Pluracol E400, E600, E1450 (see Polyethylene Glycol), 44
PMB-200 (see Estrogens, Conjugated),
76
PMB-400, component of (see Estrogens, Conjugated),
76
PMEA, 93
PMM (see Pentamethylmelamine),
24
Pneumovax,
93
Podofilox,
99
Podophyllic acid (see Mitopodozide),
23
Podophyllotoxin
derivative (see Etoposide*),
20
Poly AU, 65
Poly I: Poly C12U, 65, 91
Poly I:C (see 5'-Inosinic acid polymers), 65
Poly I:Poly C with Poly-l-lysine stabilizer, 65
Poly IC/LC (see Poly I:Poly C with Poly-I-iysine stabilizer), 65
Polyestradiol Phosphate,
79
Polyethylene Glycol, 44
PolyI: Poly C12U (see Ampligen),
65, 91
PORF (see Porfiromycin),
25
Porfimer Sodium, 24
Porfiromycin,
25
Porfiromycine (see Porfiromycin), 25
Porton asparaginase (see Asparaginase),
61
PRD (see Prednisone),
79
PRDL (see Prednisolone),
79
PRED (see Prednisone),
79
Predalone T.B.A. (see Prednisolone Tebutate),
79
Predate (see Prednisolone Acetate),
79
Predate-S (see Prednisolone Sodium Phosphate),
79
Predne-Dome#
(see Prednisolone),
79
Prednimustine,
25
Prednisolone,
79
Prednisolone
Acetate,
79
Prednisolone
Sodium Hernisuccinate,
79
Prednisolone Sodium Phosphate,
79
Prednisolone sodium succinate (see Prednisolone Hemisuccinate)
79
Prednisolone Tebutate,
79
Prednisone,
79
Prednival*#,
79
Pregnenolone*
Succinate, 80
Premarin (see Estrogens, Conjugated),
76
Premarin with Methyltestosterone,
component of (see Methyltestosterone),
165
78
Table of Contents
Manuals
P (continued)
Premarin with Methyltestosterone, component of (see Estrogens, Conjugated), 76
Primaquine Phosphate, 99
Primaxin, component of (see Cilastatin Sodium), 17
Primaxin, component of (see Imipenem), 21
Primaxin, component of (see Imipenem-Cilastatin), 97
Primocort (see Desoxycorticosterone Acetate), 74
Primocortan (see Desoxycorticosterone Acetate), 74
Probenecid, 44
Procarbazine* (HC1), 25
Prochlorperazine Maleate, 45
Prochlorperazine*, 45
Procrit (see Erythropoietin), 62, 96
Procytox (see Cyclophosphamide*), 18
Prodasone (see Medroxyprogesterone Acetate), 77
Prodel (see Dydrogesterone*), 75
Prodrox (progestin) (see Hydroxyprogesterone Caproate), 77
Progestal (see Medroxyprogesterone Acetate), 77
Progesterone*, 80
Progynon B (estrogen) (see Estradiol Benzoate), 75
Progynon# (estrogen) (see Estradiol), 75
Prokine (see Sargramostim), 66
Proleukin (see lnterleukin-2), 63
Proloid (see Thyroglobulin), 80
Proloprim (see Trimethoprim), 46, 100
Promacortine (see Methyiprednisolone), 78
Promazine HCI*, 45
Promethazine HCI*, 45
2-Propanimine (see Iproplatin), 21
2-Propenamide (see Anthramycin), 15
2-Propenamide (see Bromacrylide#), 16
Proresipar (see Mitopodozide), 23
Protease inhibitor, 93
Protein A Staphylococcus Aureus, 65
Protivar (see Oxandrolone*), 79
Protobolin (see Methandrostenolone), 78
Protostat (see Metronidazole), 98
Protropin (see Human Growth Hormone), 92
Protropin (see Somatrem), 80
Proventil (see Albuterol), 39
Prover (see Medroxyprogesterone Acetate), 77
Provera (see Medroxyprogesterone Acetate), 77
Proverone (see Medroxyprogesterone Acetate), 77
PRZF (see Pyrazofurin#), 25
Pseudomonas aeruginosa, 65
166
Table of Contents
Manuals
P (continued)
PSK, 65
Psorion (see Betamethasone Dipropionate), 73
PSP-IV (see Prednisolone Sodium Phosphate), 79
PTC (see Peptochemio), 24
PTG (see Teniposide), 26
Purinethiol (see Mercaptopurine*), 22
Purinethol (see Mercaptopurine*), 22
Puromycin (HCI), 25
Puromycin (see Puromycin (HCI)), 25
Pyran (see Pyran copolymer), 65
Pyran copolymer, 65
Pyran XA 124-177 (see Pyran eopolymer), 65
Pyranone Phosphate (see Fostriecin Sodium), 20
Pyrantel Pamoate, 99
Pyrazinamide, 45, 99
Pyrazine diazohydroxide, 25
Pyrazine Hexahydride (see Piperazine), 44
Pyrazofurin#, 25
Pyrazolo (2,3-a)imadazolidine (see Pyrazoio-Imidazole compound),
Pyrazolo-Imidazole compound, 25
Pyrazoloacridine, 25
Pyrazomycin (see Pyrazofurin#), 25
Pyrictal (see Phetharbital), 24
Pyridoxine, 45
Pyrimethamine, 45
PZA (see Pyrazinamide), 45
PZD (see Piperazinedione compound), 24
PZF (see Pyrazofurin#), 25
Q
Quantril (see Benzquinamide), 39
Quiess (see Hydroxyzine HC1), 42
QUIN (see Quinacrine (HCI)), 45
Quinacrine (HC1), 45
Quinacrine, 99
Quinactine (see Quinacrine (HCI)), 45
Quinestrol, 80
Quingestanol* Acetate, 80
Quingestrone#, 80
Quinidine, 45
Quinomycin A (see Echinomycin), 19
167
25
Table of Contents
Manuals
R
R 17,934 (see Nocodazole (Belgium)), 23
R 9985 (see Methotrexate*),
22
R-12,564 (see Levamisole HCI*), 64
R-1625 (antipsychotic) (see Haloperidol),
42
R-246 (see Triethylenemelamine),
27
R-33-812 (anti-emetic) (see Domperidone),
41
R-41,400 (see Ketoconazole),
77
R-4749 (see Droperidol*),
41
R-48 (see Chlornaphazine*),
40
R-52,211 (see Itraconazole),
42, 97
R-52 (see Mannosulfan),
22
R-met Hu G-CSF (see G-CSF), 41
R-met Hu G-CSF (see Filgrastim), 62
R-Verapamil HCI, 45
RA (see Retinyl Acetate), 51
RA-233 (see Mopidamol),
23
Ra-8 (coronary vasodilator) (see Dipyridamole),
41
Radinyl (see Etanidazole),
41
Ranitidine HCI, 99
Razoxane,
25
RBD (see Zorubicin (HCI)), 28
RC-160 (see Vapreotide),
27
Recombinant Alpha 2 interferon (see Interferon Alfa-2b), 63
Recombinant Human GM-CSF (see CSF-GM), 40
Recombinant human growth hormone, 94
Recombinant interferon Gamma (see Interferon Alfa-2b), 63
Recombinant Leukocyte A interferon (see Interferon Alfa-2b),
Recombinant Soluble CD4, 66
Recombinant Soluble T4, 66
Recominbant Tumor Necrosis Factor, 66
Regamycin# (see Porfiromycin), 25
Reglan (anti-emetic) (see Metoclopramide (HCI)*), 43
Remsed (anti-emetic) (see Promethazine HCI*), 45
Repromap (see Medroxyprogesterone
Acetate), 77
Repromix (see Medroxyprogesterone
Acetate), 77
Retin-A (see Tretinoin), 51
Retinoic acid (see Tretinoin), 51
13-cis-Retinoic acid (see Retinoic acid), 51
Retinyl Acetate, 51
Retrone (see Dydrogesterone*),
75
Retrovir (see Azidothymidine, Zidovudine*),
16, 28, 91
rgpl20 CHO, 94
rgpl20/HIV-1
(IIIB), 94
168
63
Table of Contents
Manuals
R (continued)
Rhenium-186,
45
Rheumatrex
(antimetabolite)
(see Methotrexate*),
22
rHGH, 93
Rhizoxin, 25
rHu-EPO (see Erythropoietin),
62, 96
Rianil (see Chlorotrianisene),
74
Ribavirin, 94
Ribo-azauracil
(see 6-Azuridine),
16
Ribo-azuracil (see 6-Azuridine),
16
Riboazuracil (see 6-Azuridine),
16
Riboflavin, 45
Riboprine*,
25
Riboxamide (see Tiazofurin),
26
Rifabutin,
99
Rifadin (see Rifampin),
25, 99
Rifampin,
25, 99
Rimactane (see Rifampin), 25, 99
Rimifon# (see Isoniazid*), 97
Ritalin (see Methylphenidate
HCI), 43
Ro 03-8799 (see Pimonidazole),
44
Ro 2-9757 (see Fluorouracil*),
20
Ro 21-0702 (see Flurocitabine#),
20
Ro 21-3981/003 (see Midazolam HCI), 44
Ro 21-8837 (see Estramustine),
75
Ro 21-8837/001 (chemotoxic hormone) (see Estramustine
Ro 22-2296/000 (see Estramustine),
75
Ro 22-8181 (see Interferon Alfa-2a), 63
Ro 24-2027 (see Dideoxycytidine),
92
Ro 4-3780 (see Retinoic acid), 51
Ro 5-9963 (see Desmethylmisonidazole),
40
Ro-03-8799,
45
Ro-7-0582 (see Misonidazole),
44
Ro4-6467/1 (see Procarbazine* (HCI)), 25
Rocephin (see Ceftriaxone),
95
Roferon (see Interferon Alfa-2a), 63
Roferon-A (see Interferon Alfa-2a), 63
RP 2512 (see Pentamidine Isethionate),
93
RP-13057 (see Daunorubicin (HCI)*), 18
RP-22,050 (see Zorubicin (HC1)), 28
RP-6870 (see Inproquone),
21
RS-1301 (see Delmadinone Acetate), 74
RS-21592 (see Ganciclovir),
97
RS-2208 (progestin) (see Amadinone Acetate),
73
RS-3540 (see Naproxen),
44
169
Phosphate),
76
Table of Contents
Manuals
R (continued)
RS-94991-298 (see Nafarelin Acetate), 78
RU 41740 (see Biostim), 62
RU 486 (see Mifepristone), 78
RUB (see Zorubiein (HCI)), 28
Rubex (see Doxorubicin (HCI)*), 19
Rubidazone (see Zorubicin (HCI)), 28
Rubidazone hydrochioride (see Zorubicin (HCI)), 28
Rubidomycin-HC! (see Daunorubicin (HCI)*), 18
Rubomycin C (see Daunorubicin (HCI)*), 18
Rufochromomycin (see Streptonigrin), 25
Rufocromomycin (see Streptonigrin), 25
S
S-trityl-L-cysteine (see Trityl cysteine), 27
$6820 (Shionogi) (see IL-2), 63
Salisburystin (see Pentamustine), 24
Sanamicia (see Cactinomycin), 16
Sanamycin (see Cactinomycin), 16
Sandamycin (see Cactinomycin), 16
Sandostatin (see Octreotide Acetate), 65
Sandostatin, 45
Santavy's Substance F (see Colcemid), 17
Sarcolysine (see Melphalan* (HCI)), 22
Sargramostim (see GM-CSF), 66, 97
Sarkokiorin (see Melphalan* (HCI)), 22
Sarkolizin (see Melphalan* (HCI)), 22
Satric (see Metronidazole), 98
SC 11585 (see Oxandrolone*), 79
SC-10363 (see Megestrol Acetate), 78
SC-16148 (see Silandrone*#), 80
SC-19198 (see Methynodiol Diacetate#), 78
SC-9420 (see Spironolactone), 80
SC-9880 (see Fiurogestone Acetate), 76
Sch 11460 (see Betamethasone Dipropionate), 73
Sch 13521 (see Flutamide), 77
Sch-18020W (see Beclomethasone Dipropionate), 73
Seh-4358 (see Meprednisone*), 78
Sch-4831 (see Betamethasone), 73
Semustine, 25
Sendoxan (see Cyclophosphamide*), 18
Septra, component of (see Suifamethoxazole), 46
Septra, component of (see Trimethoprim), 46
Seromycin (see Cycloserine), 96
170
Table of Contents
Manuals
S (continued)
Serophene (see Clomiphene* Citrate), 74
Serotonin,
45
Serral (see Diethylstilbestrol),
75
Sexocretin (see Diethylstilbestrol),
75
SF-337 (see 8-Azaguanine),
15
SH 714 (see Cyproterone Acetate),
74
SH 741 (progestin) (see Clomegestone*
Acetate),
74
SH 818 (glucoc_rticoid) (see Ciocortolone Acetate),
74
SH 863 (see Clocortolone Pivalate), 74
SH-1040 (see Gestaclone),
77
SH-582 (see Gestonorone Caproate), 77
SH-723 (see Mesterolone),
78
SH-968 (glucocorticoid) (see Diflucortolone* Pivalate), 75
Sibol (see Diethylstilbestrol),
75
Silandrone*#,
80
Simtrazene#,
25
Sinestrol (see Hexestrol),
77
Sirprogen (see Medroxyprogesterone
Acetate),
77
SK-1133 (see Triethylenemelamine),
27
SK&F 14287 (see Idoxuridine*), 42
SK&F-7690 (see Benorterone#),
73
SK.F 104864-A (see Topotecan HCI), 27
SKF 33134-A (cardiac depressant) (see Amiodarone),
39
SN (see SR 2508), 45
SN (see Streptonigrin),
25
Sodium 2-mercaptoethane
(see Mesna*), 43
Sodium 2-mercaptoethanesulfonate
(see Mesna*), 43
Sodium bromebrate (see Cytembena),
18
Sodium Butyrate, 51
Sodium Chloride, 45
Sodium Fluoride, 45
Sodium Iodide, 45
Sodium N-Nitroso-Pyrazinamine
(see Pyrazine diazohydroxide),
Sodium Phosphate P 32, 45
Sodium Suramin (see Suramin Sodium), 26
Sodium Thiosulfate,
45
Solatene (ultraviolet screen) (see Beta Carotene),
39, 62
Solu-Cortef (see Hydrocortisone Sodium Succinate),
77
Solu-Decortin (see Prednisolone Hemisuccinate),
79
Solu-Medrol (see Methylprednisolone
Sodium Succinate),
78
Solu-Predalone
(see Prednisolone Sodium Phosphate),
79
Somatostatin,
80
Somatrem,
80
Somatuline,
80
171
25
Table of Contents
Manuals
S (continued)
Soriatane (see Acitretin), 51
SP-104 (anti-emetic) (see Tetrahydrocannabinol), 46
SP-I 77 (see Mitopodozide), 23
SP-PG, 94, 99
Spanestrin (see Ethinyl estradiol), 76
Sparfloxacin, 45, 99
Sparfosate Sodium (see PAl,A), 24
Sparine (antipsychotic) (see Promazine HCI*), 45
Sparsomycin A (see Tubercidine), 27
Sparsomycin, 25
Spectazole (see Econazole), 96
SPG (see Spirogermanium (HCI)), 25
Spiramycin, 45, 99
Spiresis (see Spironolactone), 80
Spiridon (see Spironolactone), 80
Spiro-32 (see Spirogermanium (HCI)), 25
Spirogermanium (HCI), 25
Spirohydantoin mustard# (see Spiromustine), 25
Spirolactone (see Spironolactone), 80
Spiromustine, 25
Spirone (see Spironolactone), 80
Spironolactone, 80
Spiroplatin, 25
SPL (see Spironolactone), 80
Spongo-adenosine (see Vidarabine*), 27
Spongocytidine HCI (see Cytarabine HCI), 18
Sporonax (antifungal) (see Itraconazole), 42, 97
SQ 1089 (see Hydroxyurea*), 21
SQ 15,101 (see Algestone* Acetophenide), 73
SQ 21,977 (see 6-Methylmercaptopurine riboside), 23
SQ 22558 (see Riboprine*), 25
SQ-9538 (see Testolactone), 80
SR 2508 (see Etanidazole), 41
SR-1354 (see Misonidazole), 44
SR-1530 (see Desmethylmisonidazole), 40
SRI 5244 (see Chlorozotocin), 17
SRI-1354 (see Misonidazole), 44
SRI-727 (see 2-Fluoroadenosine#), 20
ST 12 (see Dexamethasone Dipropionate), 75
St Johns Wort (see Hypericin), 92
Stanolone, 80
Stanozolol*, 80
Stavudine (see D4T), 92
Stemex (see Paramethasone* Acetate), 79
172
Table of Contents
Manuals
S (continued)
Stenolon (see Methandrostenolone),
78
STEPA (see Thiotepa*),
26
Sterane (see Prednisolone),
79
Sterane IM and IA (see Prednisolone Acetate),
79
Sterecyt (see Prednimustine),
25
Steronyi (see Methyltestosterone),
78
STGDR (see Diglycoaldehyde),
19
Stil-Rol (see Diethylstilbestrol),
75
Stilbestrol (see Diethylstilbestrol),
75
Stilbetin (see Diethylstiibestrol),
75
Stilboestroform (see Diethylstilbestrol),
75
Stiletin# (see Diethylstilbestrol),
75
Stilkap (see Diethylstilbestrol),
75
Stiilomycin (see Puromycin (HCI)), 25
Stilphostrol (estrogen) (see Diethyistilbestrol
Diphosphate),
75
STN (see Streptonigrin),
25
Stoxil (see Idoxuridine*),
42
STP (see Streptonigrin),
25
STR (see Streptozocin),
25
Strept (see Streptozocin),
25
Streptonigrin,
25
Streptozocin,
25
Streptozoticin
(see Streptozocin),
25
Streptozotocin (see Streptozocin),
25
Strontium, 26
Stylomycin (see Puromycin (HCI)), 25
STZ (see Streptozocin),
25
Substance F (Reichstein's)
(see Colcemid),
17
Sucralfate,
46
Sulestrex#
(see Estropipate),
76
Sulfactol# (see Sodium Thiosulfate),
45
Sulfadiazine,
46, 100
Sulfadoxine/Pyrimethamine
(see Fansidar), 41
Sulfamethoxazole
(see Bactrim/Septra),
95
Sulfamethoxazole,
100
Sulfatrim, component of (see Sulfamethoxazole),
46
Sulfatrim, component of (see Trimethoprim),
46
Sulfonamide Duplex, component of# (see Sulfadiazine),
46
Sulfonate (see Mesna*), 43
Sulindac, 46
Sulofenur,
26
Superanaboion
(see Nandrolone Phenpropionate),
79
Suprafact (see Busrelin Acetate), 73
Suramin Sodium, 26
173
:_
Table of Contents
Manuals
S (continued)
Symetamine (see Terephthalamidine), 26
Synandrets (see Methyltestosterone), 78
Synandrol (see Testosterone Propionate), 80
Synandrol F (see Testostosterone), 80
Synandrotabs (see Methyltestosterone), 78
Synarel (see Nafarelin Acetate), 78
Synchrosyn (see Chlormadinone* Acetate), 73
Synchrosyn P (see Chlormadinone* Acetate), 73
Syncort (adrenocortical steroid) (see Desoxycorticosterone Acetate), 74
Synerone# (see Testosterone Propionate), 80
Synestrol (see Hexestrol), 77
Synestrol# (see Dienestrol), 75
Syngesterone (see Progesterone), 80
Syngestrets (see Progesterone), 80
Synmiol (radiosensitizer) (see Idoxuridine*), 42
Synoestrol (see Hexestrol), 77
Synthoestrin (see Diethylstilbestroi), 75
Synthovo (see Hexestrol), 77
Synthroid (see Levothyroxine Sodium), 77
Syntocinon (see Oxytocin), 79
Syntofolin (see Diethylstilbestrol), 75
Syntrogene (see Hexestrol), 77
SZ (see Streptozocin), 25
SZC (see Streptozocin), 25
T
Tabloid (see Thioguanine*), 26
TAC-3 (see Triamcinolone Acetonide), 81
TAC-40# (see Triamcinolone Acetonide), 81
TAC-D# (see Triamcinolone Diacetate), 81
TACE (see Chlorotrianisene), 74
Tagamet (see Cimetidine), 40
Taliblastine (see Thalicarpine), 26
Talisomycin, 26
Tallysomycin A# (see Talisomycin), 26
TAM (see Tamoxifen Citrate), 80
Tamofen (see Tamoxifen Citrate*) 80
Tamoxifen (see Tamoxifen Citrate), 80
Tamoxifen Citrate, 80
TAP-144 (see Leuprolide Acetate), 77
Tarabine (see Cytarabine), 51
TATBA (see Triamcinolone Hexacetonide), 81
Taxol (see Paclitaxel), 24
174
Table of Contents
Manuals
T (continued)
Taxotere,
26
Tazobactam,
26
TC (see Thalicarpine),
26
3TC, 94
TCAR (see Tiazofurin),
26
TCGF (see Interleukin-2),
63
TCN (see Triciribine phosphate),
27
TCN-P (see Triciribine Phosphate),
27
TdR (see Thymidine),
26
Teebacin (see Para-aminosalicylic acid), 98
Teebaconin (see Isoniazid), 97
Tegafur, 26
Tegison (see Etretinate),
51
TEM (see Triethylenemelamine),
27
Tenex (see Guanfacine HCI), 42
Teniposide,
26
Teolit (see Testolactone*),
80
Tepirone (see Razoxane),
25
Terazol (see Terconazole),
100
Terconazole,
100
Terephthalamidine,
26
Terolut (see Dydrogesterone*),
75
Teroxirone,
26
Terrastatin, component of (see Nystatin), 98
Tertroxin (see Liothyronine Sodium), 77
Teslac (see Testolactone*),
80
Teslak (see Testolactone*),
80
TESP (see Thiotepa*),
26
Tespa (see Thiotepa*),
26
Tespamin (see Thiotepa*),
26
Tespamine (see Thiotepa*),
26
Testolacton (see Testolactone*),
80
Testolactone,
80
Testoral (see Fluoxymesterone),
76
Testosteroid (see Testosterone),
80
Testosterone,
80
Testosterone
Cypionate,
80
Testosterone
Enanthate,
80
Testosterone
Ketolaurate,
80
Testosterone
Phenylacetate#,
80
Testosterone
Propionate,
80
Testoviron (see Methyltestosterone),
78
Testred (ICN) (see Methyltestosterone),
78
Testryl# (see Fluoxymesterone),
76
175
Table of Contents
Manuals
T (continued)
TET (see Triethylenemelamine),
27
Tetrahydrocannabinol,
46
Tetramizole (see Levamisole HCI), 64
Tetrandirine (see D-Tetrandrine),
26
Tetrandrin (see D-Tetrandrine),
26
Tetraplatin,
26
Tetrastatin, component of (see Nystatin), 98
TF-128 (see Aminothiadiazole),
15
TFI" (see Trifluridine),
100
TG (see Thioguanine*),
26
6-TG (see Thioguanine*),
26
TGdR (see Beta-TGdR),
16
TGU (see Triglycidylurazol),
27
Thaliblastine (see Thalicarpine),
26
Thalicarpin (see Thalicarpine),
26
Thalicarpine, 26
THC (see Tetrahydrocannabinol),
46
Theelin (see Estrone),
76
Theelol# (see Estriol), 76
Thenylidene (see Teniposide), 26
Thenylidine-Lignan-P
(see Teniposide), 26
Theophylline,
46
Theprubicin,
26
THF (see Thymic Humoral Factor), 94
Thiabendazole,
100
Thiamiprine,
26
Thiatriamide (see Azetepa#),
16
Thio-TEPA (see Thiotepa*),
26
Thiocarb (see Diethyldithiocarbamate),
41
Thiofozil (see Thiotepa*),
26
Thioguanine*,
26
6-Thioguanine (see Thioguanine*),
26
Thioguanine deoxyriboside (see Beta-TGdR),
16
Thioguanosine deoxyriboside (see Alpha-TGdR),
15
6-Thiohypoxanthine
(see Mercaptopurine*),
22
6-Thioinosine (see 6-Mercaptopurine
riboside), 22
Thiophosphamide
(see Thiotepa*), 26
6-Thiopurine (see Mercaptopurine*),
22
Thiotef (see Thiotepa*),
26
Thiotepa*,
26
6-Thioxopurine (see Mercaptopurine*),
22
Thorazine (anti-emetic (see Chlorpromazine*),
40
THP (see Theprubicin),
26
Thymic Humoral Factor, 94
176
Table of Contents
Manuals
T (continued)
Thymidin (see Thymidine), 26
Thymidine, 26
Thymine deoxyriboside (see Thymidine), 26
Thymopentin,
94
Thymosin, 66
Thyractin# (see Thyroglobulin),
80
Thyrar (see Thyroid), 81
Thyroglobulin,
80
Thyroid, 81
Thyrolar (see Liotrix), 77
Thyroprotein#
(see Thyroglobulin),
80
Thyrotropin,
81
Tiamiprine (see Thiamiprine),
26
Tiazofurin, 26
TIBO derivatives, 94
TIC (see TIC-mustard),
27
TIC NH2 (misc. agent) (see TIC-mustard),
27
TIC-mustard,
27
Tice BCG Vaccine (see Interleukin-2),
64
Tifosyl (see Thiotepa*),
26
Tigan (anti-emetic) (see Trimethobenzamide
HCI), 46
Tigestol*, 81
TIL/TNF, 66
Tilorone, 66
Timp-2, 27
Tindurin (see Pyrimethamine),
45
Tinver, component of (see Sodium Thiosulfate),
45
Tio-TEF (see Thiotepa*),
26
Tioconazole,
100
Tiofosfamid (see Thiotepa*),
26
Tiofosyl (Sweden) (see Thiotepa*), 26
Tiofozil (see Thiotepa*),
26
Tioguanin (see Thioguanine*),
26
Tisin# (see Isoniazid*),
97
TL (see Testolactone*),
80
TL 476 (see Aniline mustard), 15
TLC G-65, 100
TLC-Dox 99 (see Liposome-Doxorubicin
Kit), 21
TMCA, 27
TMP (see Trimethoprim),
46
TMP/SMX (see Bactrim/Septra),
95
TMTX (see Trimetrexate),
27
TMX (see Tamoxifen Citrate), 80
TNCA (see TMCA), 27
177
Table of Contents
Manuals
T (continued)
TNF (see Tumor necrosis factor), 66
TNF Transd TIL (GTI), 66
TNO-6 (see Spiroplatin),
25
TNP-470, 94, 100
Tobradex, component of (see Dexamethasone),
40, 74
Tomosar (see Menogaril), 22
Topotecan HCI, 27
Toradol (anti-inflammatory;
analgesic) (see Ketorolac Tromethamine),
Toremifene Citrate, 81
Toyamicin (see Chromomycin A3#), 17
Toyocamycin, 27
Toyokamycin (see Toyocamycin), 27
Toyomycin (see Chromomycin A3#), 17
TP (see Testosterone Propionate),
80
TP OKT 3 Lymphoctyes, 66
TP-5 (see Thymopentin),
94
Tralonide#,
81
Tramacin# (see Triamcinolone Acetonide),
81
Tramisole (see Levamisole HCI), 64
trans-Diethylstilbestrol
(see Diethylstibestrol),
75
Trans-Methyl CCNU (see Semustine), 25
Trecator-SC (see Ethionamide),
96
Trental (vasodilator) (see Pentoxifylline), 44
Treosulfan,
27
Trestolone Acetate#,
81
Tretamine (see Triethylenemelamine),
27
Tretinoin, 51
Trexan (see Naltrexone),
44
Triacet (see Triamcinolone Acetonide), 81
Triamcinolone Acetonide Sodium Phosphate,
81
Triamcinolone Acetonide, 81
Triamcinolone Diacetate, 81
Triamcinolone Hexacetonide,
81
Triamcinolone,
81
Triamelin (see Triethylenemelamine),
27
Triamolone 40 (see Triamcinolone Diacetate),
81
Triamonide 40 (see Triamcinolone Acetonide),
81
Triavil (see Perphenazine),
44
Triazinate (see Baker's antifol), 16
Triazine antifol, 27
Triazinetrione
triepoxide (see Teroxirone),
26
Triazure# (see Azaribine*),
15
Trichosanthin (see GLQ223), 92
Triciribine Phosphate,
27
178
42
Table of Contents
Manuals
T (continued)
Tricyclic nucleoside 5'-phosphate#
(see Triciribine Phosphate),
27
Tricycioside phosphate (see Triciribine Phosphate),
27
Triethylene thiophosphoramide
(see Thiotepa*),
26
Triethylenemelamine,
27
Trifluorothymidine
(see F3TDR), 20
Triflupromazine
HCI*, 46
Trifluridine (see F3TDR), 20
Trifluridine,
94, 100
Triglycidylurazol,
27
Trilafon (see Perphenazine),
44
Trilostane,
81
Trimethobenzamide
HCI, 46
Trimethoprim
(see Bactrim/Septra),
95
Trimethoprim,
46, 100
Trimethylcolchicinic
acid, methyl ester, L-tartrate (1:1) (see TMCA),
Trimetrexate
glucuronate (see Trimetrexate),
27
Trimetrexate,
27, 100
Trimpex (see Trimethoprim),
46, 100
Trioxifene Mesylate, 81
Triptorelin,
81
Trisodium phosphonoformate
(see Foscarnet Sodium), 97
Trityl cysteine, 27
Tritylthioalanine
(see Trityl cysteine), 27
Trofosfamide,
27
Tropisetron,
46
Trymex# (see Triamcinolone Acetonide),
81
TSP (see Thiotepa*),
26
TSPA (see Thiotepa*),
26
TT-6 (see Thioguanine*),
26
TI'-G (see Thioguanine*),
26
Tubercidin (see Tubercidine),
27
Tubercidine,
27
Tumor necrosis factor, 66
Tumor primed Anti-CD3,
66
Turloc (see Meturedepa),
23
Tymtram (alkylating agent) (see Cyclophosphamide*),
18
TZT (see Baker's antifol), 16
U
U-10,974 (see Flumethasone*),
76
U-10,997 (see Mibolerone),
78
U-10071 (see Tubercidine),
27
U-11100A (see Nafoxidine HCL), 78
179
27
Table of Contents
Manuals
u
U-12,019E (tee l_t_prednisolone
u-12 1
Sodium Phosphate),
17
U-13,933(tee A_a_#),
15
U-14,743(teePocf'_romycin),
25
U-15,614(seeTre_toloneAcetate#),81
U-15167 (seeNogalamycin#),23
U-19183 (seeSparsomycin),
25
U-19763 (seeBolmtcronc#),73
u-1'z00ee
51
U-19920A (,ecC_tambincHCf), 18
U-22,550 (tree _rmm),
73
U-27,182 (rag _pt_ofen),
41
U-31,889 (see Alptszolam),
39
U-42,126 (see Acivicia), 15
U-52,047 (see Meaogadl), 22
U-54,461 (see Bropifiminc),
16
U-73,975 (see Adozelesin),
15
U-77,233 (see Tetraplatin),
26
U-78,938 (tee _aplatin),
18
U-7800 (gluctx:otticoid) (see Fluprednisolone*),
76
U-8344 (see Uracil Mustard*), 27
U-g471 (see Medrysone*), 77
U-8614 (tat _holone),
76
U-87_01, 100
U-8839 (tee Medroxyprogesterone Acetate), 77
U-90152, 94
U-9889 (tee Streptozocin), 25
Uendex (see Dcxtran Sulfate), 96
UHN2 (see Uracil Mustard*), 27
Ultandren (tee Fluoxymesterone), 76
Ultr_x_r_
(tec Prednisone), 79
UN 2579 0_c Picetazine), 44
UN 2685 (_,ee Pipctazine), 44
Unamycin B (see Toyocamycin), 27
Uracil (see Uraci_ Mustard*), 27
Uracil Mustard*, 27
Uracil ribot_e (tec Ufidine), 27
Uractone (see Spironolactone), 80
Uramustin (see Uracil Mustard*), 27
Urarnustine (see Uracil Mustard*), 27
Urba_n (see Methylprednisolone),
78"
Urd (tee Uridine), 27
Ures (t_ H_iror/m_*),
21
Ureckqm, 27
180
78
Table of Contents
Manuals
U (continued)
Urethane,
27
Urethimine (see Uredepa),
27
Uricemil (see Allopurinol*),
39
Uridin (see Uridine), 27
Uridine, 27
Uriprim (see Allopurinoi*),
39
Urokinase,
46
Urosin (see Allopurinol*),
39
Uticort (see Betamethasone
Benzoate),
Uvilon (see Piperazine),
44
73
V
Vagestrol# (see Diethylstilbestrol),
75
Vagistat (see Tioconazole),
100
Valisone (see Betamethasone
Valerate),
73
Vancenase (see Beclomethasone
Dipropionate),
73
Vanceril (see Beclomethasone
Dipropionate),
73
Vapreotide,
27
Vasocidin Solution (see Prednisolone Sodium Phosphate),
79
Vasorome (see Oxandrolone*),
79
VaxSyn, 94
VBL (see Vinblastine* Sulfate), 27
VCN (see Vibrio cholera neuraminidase),
66
VCR (see Vincristine*
Sulfate), 28
Vee M-26 (see Teniposide),
26
Vehem (see Teniposide),
26
VELB (see Vinblastine* Sulfate), 27
Velban (see Vinblastine* Sulfate), 27
Velsar (see Vinblastine Sulfate), 27
Vengicide (see Toyocamycin),
27
Ventolin (see Albuterol),
39
Vepesid (see Etoposide*),
20
Veramix (see Medroxyprogesterone
Acetate),
77
Verapamil (HCI)*, 46
Verapamil (Isoptrin) (see Verapamil (HCi)*), 46
Vercyte (see Pipobroman*),
24
Verelan (see Verapamil (HCI)*), 46
Vermex (see Piperazine),
44
Verospirone (see Spironolactone),
80
Versed (anesthetic; CNS depressant) (see Midazolam HCI), 44
Vesprin (see Triflupromazine
HCI), 46
Vibrio cholera neuraminidase,
66
Vidarabin (see Vidarabine*),
27
181
Table of Contents
Manuals
V (continued)
Vidarabin-Thilo
(see Vidarabine), 27
Vidarabine,
100
Vidarabine*,
27
Videx (see Dideoxyinosine),
92
Vinblastine (see Vinblastine* Sulfate), 27
Vinblastine* Sulfate, 27
Vincaleukoblastine
(see Vincristine* Sulfate), 28
Vincaleukoblastine
sulfate (see Vinblastine* Sulfate),
Vincasar (see Vincristine*
Sulfate), 28
Vincristine (see Vincristine* Sulfate), 28
Vincristine* Sulfate, 28
Vincrystine (see Vincristine* Sulfate), 28
Vindesine Sulfate, 28
Vindesine, 28
Vinepidine Sulfate, 28
Vinglycinate Sulfate, 28
Vinkristin (see Vincristine*
Sulfate), 28
Vinleurosine (see Vinleurosine Sulfate#), 28
Vinleurosine Sulfate#,
28
Vinorelbine,
28
Vinostatin (see Zinostatin),
28
Vinrosidine Sulfate#,
28
Vinzolidine Sulfate, 28
Vira-A (see Vidarabine*),
27
Virazole (see Ribavirin), 94
Vistaril (see Hydroxyzine HC1), 42
Vistrax (tranquilizer) (see Hydroxyzine HC1), 42
Vit A (see Retinoic acid), 51
Vit A (see Tretinoin),
51
Vit D3 (see 1,25-Dihydroxy-vitamin D3), 51
Vitamin A acid (see Tretinoin), 51
13-cis-Vitamin A acid (see Retinoic acid), 51
Vitamin B6 (see Pyridoxine HCI), 45
Vitamin D, 81
Vitamin E, 46
Vitarabin (see Vidarabine*),
27
Vitarin (see Vidarabine*),
27
VLB (see Vinblastine* Sulfate), 27
VM-26 (see Teniposide),
26
VNB (see Vinorelbine),
28
VNCR (see Vincristine*
Sulfate), 28
VP-16 (see Etoposide*),
20
VP-16-213 (see Etoposide*),
20
Vumon (see Teniposide),
26
VZL (see Vinzolidine Sulfate), 28
182
27
Table of Contents
Manuals
W
W-3399 (see Quingestrone#),
80
W-3566 (see Ouinestrol),
80
W-4540 (see Quingestanol* Acetate), 80
W-4869 (see Prednival*#),
79
W-5975 (see Betamethasone
Benzoate), 73
W-6495 (see Oxisuran*#),
23
Warfarin Sodium*, 46
Wazine-34 (see Piperazine),
44
Wellcome CN6134 (BW) (see C-parvum), 62
Wellcovorin
(see Leucovorin (calcium)*), 43
WIN 14833 (see Stanozolol*),
80
Win 24,540 (see Trilostane),
81
Win-27,914 (see Nivazol), 79
Winstrol (see Stanozolol*),
80
Wobenzym, 94
WR 14997 (see Cycloleucin), 18
WR 2026, 46
WR 2721 (see Ancillary drugs), 28
WR 2721, 28, 46
WR 6026, 100
WR-2721 (radioprotector)
(see Amifostine),
39
Wurmirazin (anthelmintic) (see Piperazine),
44
Wy-4036 (anti-emetic) (see Lorazepam),
43
Wy-5321 (see Diglycoaidehyde),
19
X
XA 146-85-2 (see Pyran copolymer), 65
Xanax (sedative) (see Alprazolam), 39
Xaridium (see Sodium Fluoride), 45
XB 2615 (see Teroxirone),
26
Xylocaine (see Lidocaine),
43
Y
Yodoxin (see Iodoquinol),
97
Yoshi-864, 28
YTR 830 (see Tazobactam),
26
Z
Z-4942 (alkylating agent) (see Ifosfamide*),
Zanosar (see Streptozocin),
25
Zantac (see Ranitidine HCi), 99
21
183
Table of Contents
Manuals
Z (continued)
Zeniplatin, 28
Zidovudine (see Azidothymidine), 16, 91
Zidovudine*, 28
Zinostatin, 28
Zitostop (see Mannosulfan), 22
Zofran (see Ondansetron HCI), 44
Zoladex (see Gosrelin), 77, 81
Zorubicin (HCI), 28
Zovirax (see Acyclovir Sodium), 39, 95
Zuclomiphene citrate (see Clometherone#), 74
Zuclomiphene citrate (see Clomiphene* Citrate), 74
Zyloprim (see Allopurinol*), 39
Zyloric (see Allopurinol*), 39
Zymafluor (see Sodium Fluoride), 45
184