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  • Cefazolin

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    Danielle Marie Samblaceno
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    Cefazolin (brand name Fonvicol) is a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections including skin, respiratory, urinary tract, bone and joint infections as well as sepsis. It works by binding to bacterial cell membranes and inhibiting cell wall synthesis. Common side effects include diarrhea, nausea, vomiting and rashes while allergic reactions like anaphylaxis are also possible. Nurses monitor patients for signs of infection, allergic reaction, and gastrointestinal issues when administering cefazolin intravenously.

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    Drug Study

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    Cefazolin (brand name Fonvicol) is a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections including skin, respiratory, urinary tract, bone and joint infections as well as sepsis. It works by binding to bacterial cell membranes and inhibiting cell wall synthesis. Common side effects include diarrhea, nausea, vomiting and rashes while allergic reactions like anaphylaxis are also possible. Nurses monitor patients for signs of infection, allergic reaction, and gastrointestinal issues when administering cefazolin intravenously.

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    © All Rights Reserved
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    187 views3 pages

    Cefazolin

    Uploaded by

    Danielle Marie Samblaceno
    Cefazolin (brand name Fonvicol) is a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections including skin, respiratory, urinary tract, bone and joint infections as well as sepsis. It works by binding to bacterial cell membranes and inhibiting cell wall synthesis. Common side effects include diarrhea, nausea, vomiting and rashes while allergic reactions like anaphylaxis are also possible. Nurses monitor patients for signs of infection, allergic reaction, and gastrointestinal issues when administering cefazolin intravenously.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Drawing

    Generic Name
    Brand Name
    Classification
    Action
    Dosage

    Cefazolin
    Fonvicol
    Therapeutic: anti-infectives
    Pharmacologic: first-generation cephalosporins
    Binds to bacterial cell membranes, inhibits cell wall synthesis.
    Therapeutic Effect: Bactericidal
    1gm IV q8
    Skin and skin structure infections (including burn wounds)
    Pneumonia
    UTI
    Bone and joint infections

    Indication

    Septicemia
    Perioperative prophylaxis
    Biliary tract infections
    Genital infections
    Bacterial endocarditis prophylaxis for dental

    Contraindicatio
    n

    Upper respiratory tract procedures.


    Hypersensitivity to cephalosporins
    Serious hypersensitivity to penicillins.

    History of GI disease, especially colitis.


    Side Effects and Seizures (high doses)

    Diarrhea
    Nausea
    Vomiting
    Adverse Effects

    Cramps
    Rashes
    Pruritis
    Urticarial

    Nursing
    Responsibilities

    Phlebitis at IV site.
    1. Assess for infection (vital signs; appearance of wound, sputum,
    urine, and stool; WBC) at beginning and during therapy.
    2. Before initiating therapy, obtain a history to determine
    previous use of and reactions to penicillins or cephalosporins.
    Persons with a negative history of penicillin sensitivity may
    still have an allergic response.
    3. Obtain specimens for culture and sensitivity before initiating
    therapy. First dose may be given before receiving results.
    4. Observe patient for signs and symptoms of anaphylaxis (rash,
    pruritus, laryngeal edema, wheezing). Discontinue drug and
    notify health care professional immediately if these problems
    occur. Keep epinephrine, an antihistamine, and resuscitation
    equipment close by in case of an anaphylactic reaction.
    5. Monitor bowel function. Diarrhea, abdominal cramping, fever,
    and bloody stools should be reported to health care
    professional promptly as a sign of pseudomembranous colitis.
    May begin up to several weeks following cessation of therapy.
    6. Assess patient for skin rash frequently during therapy.
    Discontinue cephalosporins at first sign of rash; may be life
    threatening. Stevens-Johnson syndrome or toxic epidermal
    necrolysis may develop. Treat symptomatically; may recur
    once treatment is stopped.
    7. Lab Test Considerations: May cause positive results for

    Coombs test in patients receiving high doses or in neonates


    whose mothers were given cephalosporins before delivery.
    8. May cause serum AST, ALT, alkaline phosphatase, bilirubin,
    LDH, BUN, creatinine.
    9. May rarely cause leukopenia, neutropenia, agranulocytosis,

    Source

    thrombocytopenia, or eosinophilia.
    Davis's Drug Guide for Nurses by Deglin, Judith Hopfer, Sanoski,
    Cynthia, Vallerand, April, 14th Edition; pages 284-286

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