XWX PDF
XWX PDF
and
Related Diseases Report
WORLD
Version posted at www.hpvcentre.net on 15 December 2016
- ii -
ICO Information Centre on HPV and Cancer (HPV Information Centre), 2016.
All rights reserved. HPV Information Centre publications can be obtained from the HPV Informa-
tion Centre Secretariat, Institut Catal dOncologia, Avda. Gran Via de lHospitalet, 199-203 08908
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The development of this report has been supported by grants from the European Comission (7th Frame-
work Programme grant HEALTH-F3-2010-242061, HEALTH-F2-2011-282562, HPV AHEAD).
Recommended citation:
Bruni L, Barrionuevo-Rosas L, Albero G, Serrano B, Mena M, Gmez D, Muoz J, Bosch FX, de Sanjos
S. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and
Related Diseases in the World. Summary Report 15 December 2016. [Date Accessed]
Abbreviations
Table 1: Abbreviations
Abbreviation Full term
HPV Human papillomavirus
PREHDICT Project Health economic modelling of prevention strategies for HPV-related diseases in
European countries
HPV Information Centre ICO Information Centre on HPV and Cervical Cancer
GW Genital warts
RRP Recurrent respiratory papillomatosis
SIL Squamous intraepithelial lesions
LSIL Low-grade cervical lesions
HSIL High-grade cervical lesions
ICC Invasive cervical cancer
CIS Carcinoma in situ
CIN Cervical intraepithelial neoplasia
AIN2/3 Anal intraepithelial neoplasia of grade 2 and/or 3
VIN 2/3 Vulvar intraepithelial neoplasia of grade 2 and/or 3
VaIN 2/3 Vaginal intraepithelial neoplasia of grade 2 and/or 3
PeIN 2/3 Penile intraepithelial neoplasia of grade 2 and/or 3
95% CI 95% confidence interval
N Number of cases tested
HPV Prev HPV prevalence
ASR Age-standardised rate
MSM Men who have sex with men
Non MSM Heterosexual men
SCC Squamous cell carcinomas
STI Sexually transmitted infections
HIV/AIDS Human immunodeficiency virus/acquired immunodeficiency syndrome
TS Type specific
EIA Enzyme immunoassay
RLBM Reverse line blotting method
RFLP Restriction fragment length polymorphism
RHA Reverse hybridisation assay
RLH Reverse line hybridisation
LiPA Line probe assay
SBH Southern blot hybridisation
ISH In situ hybridisation
MABA Micro array-based assay
LBA Line blot assay
HC2 Hybrid Capture 2
SAT Suspension array technology
PCR Polymerase chain reaction
SPF Short primer fragment
q-PCR Quantitative polymerase chain reaction
RLBH Reverse line blot hybridisation
RT-PCR Real-time polymerase chain reaction
DBH Dot blot hybridisation
HR High risk
DSA Direct sequence analysis
MAA Microchip array assay
Executive summary
Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and there is
growing evidence of HPV being a relevant factor in other anogenital cancers (anus, vulva, vagina and
penis) as well as head and neck cancers. HPV types 16 and 18 are responsible for about 70% of all cer-
vical cancer cases worldwide. HPV vaccines that prevent HPV 16 and 18 infections are now available
and have the potential to reduce the incidence of cervical and other anogenital cancers.
This report provides key information for Less developed regions on: cervical cancer; other anogeni-
tal cancers and head and neck cancers; HPV-related statistics; factors contributing to cervical cancer;
cervical cancer screening practises; HPV vaccine introduction; and other relevant immunization indi-
cators. The report is intended to strengthen the guidance for health policy implementation of primary
and secondary cervical cancer prevention strategies in the region.
The World has a population of 2,716 million women aged 15 years and older who are at risk of de-
veloping cervical cancer. Current estimates indicate that every year 527,624 women are diagnosed with
cervical cancer and 265,672 die from the disease. Cervical cancer ranks* as the fourth most frequent
cancer among women in the World.
* Ranking of cervical cancer incidence to other cancers among all women according to highest incidence rates (ranking 1st). Ranking is based on crude incidence rates (actual number of
cervical cancer cases). Ranking using age-standardized rate (ASR) may differ.
Population
Women at risk for cervical cancer (Female population aged >=15 yrs) in millions 2,716.8 2,174.6 542.2
Burden of cervical cancer
Annual number of new cervical cancer cases 527,624 444,546 83,078
Standardized incidence rates per 100,000 population 14.0 15.7 9.9
Annual number of cervical cancer deaths 265,672 230,158 35,514
Standardized mortality rates per 100,000 population 6.8 8.3 3.3
Burden of cervical HPV infection
Prevalence (%) of HPV 16 and/or HPV 18 among women with:
Normal cytology 4.1 4.4 3.9
Low-grade cervical lesions (LSIL/CIN-1) 25.7 25.0 25.9
High-grade cervical lesions (HSIL/ CIN-2 / CIN-3 / CIS) 51.8 46.6 54.1
Cervical cancer 69.4 69.5 71.8
Please see the specific sections for more information.
Contents
Abbreviations iii
Executive summary iv
1 Introduction 1
9 References 264
10 Glossary 298
List of Figures
1 World geographical regions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
2 Population pyramids by World, developing and developed regions, estimates for 2015 . . . . . . . . . . . . . . . . 3
3 Population trends in four selected age groups by World, developing and developed regions for 2015 . . . . . . . . 4
4 Age-standardised incidence rates of cervical cancer in the World (estimates for 2012) . . . . . . . . . . . . . . . . 7
5 Ranking of cervical cancer versus other cancers among all women and women aged 15-44 years, according to
incidence rates in the World (estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
6 World age-standardised incidence rates by World and sub regions (estimates for 2012) . . . . . . . . . . . . . . . . 10
7 Comparison of the ten most frequent cancers in all women by World, developing and developed regions (estimates
for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
8 Comparison of the ten most frequent cancers in all women by World and continents (estimates for 2012) . . . . 12
9 Comparison of the ten most frequent cancers in women aged 15-44 years by World developing and developed
regions (estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
10 Comparison of the ten most frequent cancers in women aged 15-44 years by World and continents (estimates for
2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
11 Age-specific incidence of cervical cancer by World, developing and developed regions and five continents . . . . . 15
12 Annual number of new cases of cervical cancer by age group in developing and developed regions and five
continents World (estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
13 Annual number of cases and age-specific incidence rates of cervical cancer in the World and its regions (estimates
for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
14 Annual number of cases and age-specific incidence rates of cervical cancer in the World and its regions (estimates
for 2012) (Continued) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
15 Age-standardised mortality rates of cervical cancer in the World (estimates for 2012) . . . . . . . . . . . . . . . . 21
16 Ranking of cervical cancer versus other cancers among all women and women aged 15-44 years, according to
mortality rates in the World (estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
17 World age-standardised mortality rates of cervical cancer by World and sub regions World (estimates for 2012) . 24
18 Comparison of the ten most frequent cancer deaths in all women in the World compared to developing and
developed regions (estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
19 Comparison of the ten most frequent cancer deaths in all women in the World compared to the continents
(estimations for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
20 Comparison of the ten most frequent cancer deaths in women aged 15-44 years by World, developing and devel-
oped regions (estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
21 Comparison of the ten most frequent cancer deaths in women aged 15-44 years by World and continents (esti-
mates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
22 Age-specific mortality of cervical cancer by World and continents . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
23 Annual number of deaths of cervical cancer by age group by developing and developed regions and continents
(estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
24 Annual number of deaths and age-specific mortality rates of cervical cancer in the World and its regions (esti-
mates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
25 Annual number of deaths and age-specific mortality rates of cervical cancer in the World and its regions (esti-
mates for 2012) (Continued) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
26 Age-specific incidence and mortality rates of cervical cancer in the World and its regions (estimates for 2012) . 34
27 Comparison of cancer incidence and mortality of pharynx (excluding nasopharynx) by sex and age group in the
World. Includes ICD-10 codes: C09-10,C12-14 (estimates for 2012) . . . . . . . . . . . . . . . . . . . . . . . . . . . 76
28 Comparison of cancer incidence and mortality of pharynx (excluding nasopharynx) in males by age group in the
World and its regions. . Includes ICD-10 codes: C09-10,C12-14 (estimates for 2012) . . . . . . . . . . . . . . . . . 77
29 Comparison of cancer incidence and mortality of pharynx (excluding nasopharynx) in females by age group in
the World and its regions. . Includes ICD-10 codes: C09-10,C12-14 (estimates for 2012) . . . . . . . . . . . . . . . 78
30 Prevalence of HPV among women with normal cervical cytology in the World . . . . . . . . . . . . . . . . . . . . . 80
31 Crude age-specific HPV prevalence (%) and 95% confidence interval in women with normal cervical cytology in
the World and its regions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
32 Prevalence of HPV among women with normal cervical cytology in Africa by country and study . . . . . . . . . . 82
33 Prevalence of HPV among women with normal cervical cytology in Africa by country and study (continued) . . . 84
34 Prevalence of HPV among women with normal cervical cytology in the Americas by country and study . . . . . . 85
35 Prevalence of HPV among women with normal cervical cytology in the Americas by country and study (continued) 87
36 Prevalence of HPV among women with normal cervical cytology in the Americas by country and study (continued) 89
37 Prevalence of HPV among women with normal cervical cytology in the Americas by country and study (continued) 91
38 Prevalence of HPV among women with normal cervical cytology in Asia by country and study . . . . . . . . . . . 92
39 Prevalence of HPV among women with normal cervical cytology in Asia by country and study (continued) . . . . 94
40 Prevalence of HPV among women with normal cervical cytology in Asia by country and study (continued) . . . . 96
41 Prevalence of HPV among women with normal cervical cytology in Asia by country and study (continued) . . . . 98
42 Prevalence of HPV among women with normal cervical cytology in Asia by country and study (continued) . . . . 100
43 Prevalence of HPV among women with normal cervical cytology in Asia by country and study (continued) . . . . 102
44 Prevalence of HPV among women with normal cervical cytology in Europe by country and study . . . . . . . . . 103
45 Prevalence of HPV among women with normal cervical cytology in Europe by country and study (continued) . . 105
46 Prevalence of HPV among women with normal cervical cytology in Europe by country and study (continued) . . 107
47 Prevalence of HPV among women with normal cervical cytology in Europe by country and study (continued) . . 109
48 Prevalence of HPV among women with normal cervical cytology in Oceania by country and study . . . . . . . . . 110
49 Prevalence of HPV 16 among women with normal cervical cytology in Africa by country and study . . . . . . . . 112
50 Prevalence of HPV 16 among women with normal cervical cytology in the Americas by country and study . . . . 113
51 Prevalence of HPV 16 among women with normal cervical cytology in the Americas by country and study (con-
tinued) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114
52 Prevalence of HPV 16 among women with normal cervical cytology in Asia by country and study . . . . . . . . . 115
53 Prevalence of HPV 16 among women with normal cervical cytology in Asia by country and study (continued) . . 116
54 Prevalence of HPV 16 among women with normal cervical cytology in Europe by country and study . . . . . . . . 117
55 Prevalence of HPV 16 among women with normal cervical cytology in Europe by country and study (continued) 118
56 Prevalence of HPV 16 among women with normal cervical cytology in Oceania by country and study . . . . . . . 119
57 Prevalence of HPV 16 among women with low-grade cervical lesions in Africa by country and study . . . . . . . 120
58 Prevalence of HPV 16 among women with low-grade cervical lesions in the Americas by country and study . . . 121
59 Prevalence of HPV 16 among women with low-grade cervical lesions in the Americas by country and study
(continued) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
60 Prevalence of HPV 16 among women with low-grade cervical lesions in Asia by country and study . . . . . . . . 123
61 Prevalence of HPV 16 among women with low-grade cervical lesions in Asia by country and study (continued) . 124
62 Prevalence of HPV 16 among women with low-grade cervical lesions in Europe by country and study . . . . . . . 125
63 Prevalence of HPV 16 among women with low-grade cervical lesions in Europe by country and study (continued) 126
64 Prevalence of HPV 16 among women with low-grade cervical lesions in Oceania by country and study . . . . . . 127
65 Prevalence of HPV 16 among women with high-grade cervical lesions in Africa by country and study . . . . . . . 128
66 Prevalence of HPV 16 among women with high-grade cervical lesions in the Americas by country and study . . 129
67 Prevalence of HPV 16 among women with high-grade cervical lesions in the Americas by country and study
(continued) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130
68 Prevalence of HPV 16 among women with high-grade cervical lesions in Asia by country and study . . . . . . . . 131
69 Prevalence of HPV 16 among women with high-grade cervical lesions in Asia by country and study (continued) 132
70 Prevalence of HPV 16 among women with high-grade cervical lesions in Europe by country and study . . . . . . 133
71 Prevalence of HPV 16 among women with high-grade cervical lesions in Europe by country and study (continued) 134
72 Prevalence of HPV 16 among women with high-grade cervical lesions in Oceania by country and study . . . . . . 135
73 Prevalence of HPV 16 among women with invasive cervical cancer in Africa by country and study . . . . . . . . . 136
74 Prevalence of HPV 16 among women with invasive cervical cancer in the Americas by country and study . . . . 137
75 Prevalence of HPV 16 among women with invasive cervical cancer in the Americas by country and study (con-
tinued) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138
76 Prevalence of HPV 16 among women with invasive cervical cancer in Asia by country and study . . . . . . . . . . 139
77 Prevalence of HPV 16 among women with invasive cervical cancer in Asia by country and study (continued) . . 140
78 Prevalence of HPV 16 among women with invasive cervical cancer in Asia by country and study (continued) . . 141
79 Prevalence of HPV 16 among women with invasive cervical cancer in Europe by country and study . . . . . . . . 142
80 Prevalence of HPV 16 among women with invasive cervical cancer in Europe by country and study (continued) . 143
81 Prevalence of HPV 16 among women with invasive cervical cancer in Europe by country and study (continued) . 144
82 Prevalence of HPV 16 among women with invasive cervical cancer in Oceania by country and study . . . . . . . 145
83 Comparison of the ten most frequent HPV oncogenic types among women with and without cervical lesions by
World compared to developing and developed regions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146
84 Comparison of the ten most frequent HPV types among women with invasive cervical cancer by histology by
World, developing and developed regions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
85 Comparison of the ten most frequent HPV types in anal cancer cases in Africa and the rest of the World . . . . . 156
86 Comparison of the ten most frequent HPV types in anal cancer cases in the Americas and the rest of the World 156
87 Comparison of the ten most frequent HPV types in anal cancer cases in Asia and the rest of the World . . . . . . 157
88 Comparison of the ten most frequent HPV types in anal cancer cases in Europe and the rest of the World . . . . 157
89 Comparison of the ten most frequent HPV types in anal cancer cases in Oceania and the rest of the World . . . . 158
90 Comparison of the ten most frequent HPV types in AIN 2/3 cases in Africa and the rest of the World . . . . . . . 158
91 Comparison of the ten most frequent HPV types in AIN 2/3 cases in the Americas and the rest of the World . . . 159
92 Comparison of the ten most frequent HPV types in AIN 2/3 cases in Asia and the rest of the World . . . . . . . . 159
93 Comparison of the ten most frequent HPV types in AIN 2/3 cases in Europe and the rest of the World . . . . . . 160
94 Comparison of the ten most frequent HPV types in AIN 2/3 cases in Oceania and the rest of the World . . . . . . 160
95 Comparison of the ten most frequent HPV types in vulvar cancer cases in Africa and the rest of the World . . . . 168
96 Comparison of the ten most frequent HPV types in vulvar cancer cases in the Americas and the rest of the World 168
97 Comparison of the ten most frequent HPV types in vulvar cancer cases in Asia and the rest of the World . . . . . 169
98 Comparison of the ten most frequent HPV types in vulvar cancer cases in Europe and the rest of the World . . . 169
99 Comparison of the ten most frequent HPV types in vulvar cancer cases in Oceania and the rest of the World . . 170
100 Comparison of the ten most frequent HPV types in VIN 2/3 cases in Africa and the rest of the World . . . . . . . 170
101 Comparison of the ten most frequent HPV types in VIN 2/3 cases in the Americas and the rest of the World . . . 171
102 Comparison of the ten most frequent HPV types in VIN 2/3 cases in Asia and the rest of the World . . . . . . . . 171
103 Comparison of the ten most frequent HPV types in VIN 2/3 cases in Europe and the rest of the World . . . . . . 172
104 Comparison of the ten most frequent HPV types in VIN 2/3 cases in Oceania and the rest of the World . . . . . . 172
105 Comparison of the ten most frequent HPV types in vaginal cancer cases in Africa and the rest of the World . . . 175
106 Comparison of the ten most frequent HPV types in vaginal cancer cases in the Americas and the rest of the World176
107 Comparison of the ten most frequent HPV types in vaginal cancer cases in Asia and the rest of the World . . . . 176
108 Comparison of the ten most frequent HPV types in vaginal cancer cases in Europe and the rest of the World . . 177
109 Comparison of the ten most frequent HPV types in vaginal cancer cases in Oceania and the rest of the World . . 177
110 Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Africa and the rest of the World . . . . . . 178
111 Comparison of the ten most frequent HPV types in VaIN 2/3 cases in the Americas and the rest of the World . . 178
112 Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Asia and the rest of the World . . . . . . . 179
113 Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Europe and the rest of the World . . . . . . 179
114 Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Oceania and the rest of the World . . . . . 180
115 Comparison of the ten most frequent HPV types in penile cancer cases in Africa and the rest of the World . . . . 186
116 Comparison of the ten most frequent HPV types in penile cancer cases in the Americas and the rest of the World 186
117 Comparison of the ten most frequent HPV types in penile cancer cases in Asia and the rest of the World . . . . . 187
118 Comparison of the ten most frequent HPV types in penile cancer cases in Europe and the rest of the World . . . 187
119 Comparison of the ten most frequent HPV types in penile cancer cases in Oceania and the rest of the World . . 188
120 Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Africa and the rest of the World . . . . . . . 188
121 Comparison of the ten most frequent HPV types in PeIN 2/3 cases in the Americas and the rest of the World . . 189
122 Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Asia and the rest of the World . . . . . . . . 189
123 Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Europe and the rest of the World . . . . . . 190
124 Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Oceania and the rest of the World . . . . . 190
125 Female smoking prevalence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
126 Total fertility rates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 240
127 World prevalence of hormonal contraceptive use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
128 World HIV prevalence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
129 Percentage of 15-year-old girls who report sexual intercourse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 244
130 Worldwide status of cervical cancer screening programmes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
131 Worldwide status of HPV vaccination programmes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255
132 Worldwide prevalence of male circumcision . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 260
133 Worldwide prevalence of condom use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 262
List of Tables
1 Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iii
2 Key statistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iv
3 World population estimates (in millions), 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
4 World sociodemographic indicators, 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
5 Incidence of cervical cancer by World region and sub regions (estimates for 2012) . . . . . . . . . . . . . . . . . . . 8
6 Cervical cancer mortality by World region and sub regions (estimates for 2012) . . . . . . . . . . . . . . . . . . . . 22
7 Incidence of anal cancer by cancer registry and sex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
8 Incidence of vulvar cancer by cancer registry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
9 Incidence of vaginal cancer by cancer registry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56
10 Incidence of penile cancer by cancer registry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
11 Cancer incidence of pharynx (excluding nasopharynx) by sex, in the World and its regions. Includes ICD-10
codes: C09-10, C12-14 (estimates for 2012). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74
12 Cancer mortality of pharynx (excluding nasopharynx) by sex, in the World and its regions. Includes ICD-10
codes: C09-10, C12-14 (estimates for 2012). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74
13 Prevalence of HPV 16/18 in women with normal cervical cytology, precancerous cervical lesions and invasive
cervical cancer by World region and sub-regions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
14 Type-specific HPV prevalence in women with normal cervical cytology, precancerous cervical lesions and invasive
cervical cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
15 Type-specific HPV prevalence among invasive cervical cancer cases by histology . . . . . . . . . . . . . . . . . . . 149
16 Studies on HPV prevalence among anal cancer cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
17 Studies on HPV prevalence among AIN 2/3 cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 154
18 Studies on HPV prevalence among vulvar cancer cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161
19 Studies on HPV prevalence among VIN 2/3 cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165
20 Studies on HPV prevalence among vaginal cancer cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
21 Studies on HPV prevalence among VaIN 2/3 cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 174
22 Studies on HPV prevalence among penile cancer cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181
23 Studies on HPV prevalence among PeIN 2/3 cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
24 Studies on anogenital HPV prevalence among men . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 192
25 Studies on anogenital HPV prevalence among men from special subgroups . . . . . . . . . . . . . . . . . . . . . . 194
26 Studies on oral HPV prevalence among healthy populations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202
27 Studies on HPV prevalence among cases of oral cavity cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
28 Studies on HPV prevalence among cases of oropharyngeal cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
29 Studies on HPV prevalence among cases of hypopharyngeal or laryngeal cancer . . . . . . . . . . . . . . . . . . . 227
30 Cervical cancer screening policies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 246
31 HPV vaccination policies for the female population . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 256
32 References of studies included . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 264
33 Glossary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 298
1 Introduction
Northern Europe
Eastern Europe
Northern Africa
Central America
Eastern Africa
Middle Africa
Melanesia
Polynesia
Southern Africa
Data sources: United Nations Statistics Division- Standard Country and Area Codes Classifications.
The HPV Information Centre aims to compile and centralize updated data and statistics on HPV and
HPV-related cancers. This report aims to summarize the data available to fully evaluate the burden of
disease in the World and to facilitate stakeholders and relevant bodies of decision makers to formulate
recommendations on the prevention of cervical cancer and other HPV-related cancers. Data include rel-
evant cancer statistic estimates, epidemiological determinants of cervical cancer such as demographics,
socioeconomic factors, risk factors, burden of HPV infection in women and men, and cervical screening
and immunization practices. The report is structured into the following sections:
Section 2, Demographic and socioeconomic factors. This section summarizes the sociodemo-
graphic profile of the World. For analytical purposes, the World is divided into five regions: Africa,
the Americas, Asia, Europe and Oceania (Figure 1).
Section 3, Burden of HPV related cancers. This section describes the current burden of invasive
cervical cancer and other HPV-related cancers in the World with estimates of prevalence, incidence and
mortality rates.
Section 4, HPV related statistics. This section summarizes reports on prevalence of HPV and HPV
type-specific distribution in women with normal cytology, women with precancerous lesions and inva-
sive cervical cancer. In addition, the burden of HPV in other anogenital cancers (anus, vulva, vagina,
and penis) are presented.
Section 5, Factors contributing to cervical cancer. This section describes factors that can modify
the natural history of HPV and cervical carcinogenesis such as smoking, parity, oral contraceptive use
and co-infection with HIV.
Section 6, Sexual behaviour and reproductive health indicators. This section presents sex-
ual behaviour and reproductive health indicators that may be used as proxy measures of risk for HPV
infection and anogenital cancers.
Section 7, HPV preventive strategies. This section presents preventive strategies that include ba-
sic characteristics and performance of cervical cancer screening status, status of HPV vaccine licensure
Section 8, Protective factors for cervical cancer. This section presents the prevalence of male
circumcision and condom use.
Figure 2: Population pyramids by World, developing and developed regions, estimates for 2015
World
Males Females
Figure 3: Population trends in four selected age groups by World, developing and developed regions for
2015
World
Projections Projections
500 4,200
400 3,200
Girls 1014 yrs
Women 2564 yrs
300
2,200
200
1,200
100
200
1950
1960
1970
1980
1990
2000
2010
2020
2030
2040
2050
2060
2070
2080
2090
2100
1950
1960
1970
1980
1990
2000
2010
2020
2030
2040
2050
2060
2070
2080
2090
2100
Less developed regions
Projections Projections
Number of women (in millions)
700
Women 1524 yrs
600 5,200 All Women
500 4,200
400
3,200
Girls 1014 yrs
300
Women 2564 yrs
2,200
200
1,200
100
0 200
1950
1960
1970
1980
1990
2000
2010
2020
2030
2040
2050
2060
2070
2080
2090
2100
1950
1960
1970
1980
1990
2000
2010
2020
2030
2040
2050
2060
2070
2080
2090
2100
More developed regions
Projections Projections
Number of women (in millions)
700
600 5,200
500 4,200
400
3,200
300
2,200
200
1,200
100 Women 1524 yrs
Girls 1014 yrs All Women
Women 2564 yrs
0 200
1950
1960
1970
1980
1990
2000
2010
2020
2030
2040
2050
2060
2070
2080
2090
2100
1950
1960
1970
1980
1990
2000
2010
2020
2030
2040
2050
2060
2070
2080
2090
2100
This section describes the current burden of invasive cervical cancer in the World and its regions with
estimates of the annual number of new cases, deaths, incidence and mortality.
3.1.1 Incidence
KEY STATS.
Cervical cancer is the 2nd most common female cancer in the women
aged 15 to 44 years in World.
* Ranking of cervical cancer incidence to other cancers among all women according to highest incidence rates (ranking 1st). Ranking is based on crude incidence rates (actual number of
cervical cancer cases). Ranking using age-standardized rate (ASR) may differ.
Figure 4: Age-standardised incidence rates of cervical cancer in the World (estimates for 2012)
Table 5: Incidence of cervical cancer by World region and sub regions (estimates for 2012)
Cumulative risk (%) Ranking of CC
Area N cases Crude ratea ASRa ages 0-74 yearsb All women Women 15-44 years
World 527,624 15.1 14.0 1.4 4 2
Less developed re- 444,546 15.6 15.7 1.6 2 2
gions
More developed re- 83,078 13.0 9.9 0.9 11 2
gions
Africa 99,038 18.5 27.6 3.0 2 2
Eastern Africa 45,707 25.8 42.7 4.6 1 1
Middle Africa 11,540 17.2 30.6 3.4 1 2
Northern Africa 5,813 5.6 6.6 0.7 4 4
Southern Africa 8,652 29.3 31.5 3.1 2 1
Western Africa 27,326 17.2 29.3 3.2 2 2
Americas 83,195 17.2 14.9 1.4 4 2
Caribbean 5,018 23.6 21.0 2.0 2 2
Central America 18,792 23.1 23.5 2.3 2 1
Northern America 14,377 8.1 6.6 0.6 13 4
South America 45,008 22.2 20.3 2.0 2 2
Asia 284,823 13.7 12.7 1.3 3 2
Central Asia 5,850 18.5 18.6 1.8 2 1
Eastern Asia 78,006 10.1 7.9 0.7 7 2
Southern Asia 145,946 17.1 19.3 2.1 2 2
South-Eastern 50,566 16.6 16.3 1.7 2 2
Asia
Western Asia 4,455 3.8 4.4 0.5 11 4
Europe 58,373 15.2 11.4 1.1 6 2
Eastern Europe 33,882 21.7 16.3 1.5 4 2
Northern Europe 5,382 10.6 8.7 0.8 10 3
Southern Europe 9,285 11.6 8.5 0.8 11 2
Western Europe 9,824 10.2 7.3 0.7 14 4
Oceania 2,195 11.7 10.2 0.9 8 3
Australia & New 938 6.8 5.5 0.5 12 4
Zealand
Melanesia 1,198 26.8 33.3 3.2 2 1
Micronesia 23 8.5 8.7 0.9 6 4
Polynesia 36 10.8 11.0 1.1 5 3
Data accessed on 15 Nov 2015.
Standardised rates have ben estimated using the direct method and the World population as the reference.
Ranking of cervical cancer incidence to other cancers among all women ages 15-44 years according to highest incidence rates (ranking 1st). Ranking is based on crude incidence rates (actual
number of cervical cancer cases). Ranking using ASR may differ.
a Rates per 100,000 women per year.
b Cumulative risk (incidence) is the probability or risk of individuals getting from the disease during ages 0-74 years. For cancer, it is expressed as the % of new born children who would be
expected to develop from a particular cancer before the age of 75 if they had the rates of cancer observed in the period in the absence of competing causes.
Data sources:
1 Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 5: Ranking of cervical cancer versus other cancers among all women and women aged 15-44
years, according to incidence rates in the World (estimates for 2012)
Figure 6: World age-standardised incidence rates by World and sub regions (estimates for 2012)
World, developed and developing regions Continental subregions
Less developed 15.7
Eastern Africa 42.7
Melanesia 33.3
Southern Africa 31.5
Middle Africa 30.6
0 10 20 30 0 10 20 30 40 50
Figure 7: Comparison of the ten most frequent cancers in all women by World, developing and developed
regions (estimates for 2012)
0 15 30 45 60 75 0 15 30 45 60 75
Lung 11.1
Colorectum(a) 9.8
Stomach 7.8
Liver 6.6
Ovary 5.0
Thyroid 4.7
Oesophagus 4.1
0 15 30 45 60 75
Data accessed on 15 Nov 2015.
a Includes anal cancer (C21).
b Includes HIV disease resulting in malignant neoplasms (B21).
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 8: Comparison of the ten most frequent cancers in all women by World and continents (estimates
for 2012)
World Asia
Breast 43.1 Breast 29.1
0 15 30 45 60 75 0 15 30 45 60 75
Africa Europe
Breast 36.2 Breast 69.9
0 15 30 45 60 75 0 15 30 45 60 75
Americas Oceania
Breast 67.6 Breast 79.2
0 15 30 45 60 75 0 15 30 45 60 75
Figure 9: Comparison of the ten most frequent cancers in women aged 15-44 years by World developing
and developed regions (estimates for 2012)
0 10 20 30 40 0 10 20 30 40
Thyroid 4.7
Ovary 2.8
Colorectum(a) 2.1
Leukaemia 2.1
Stomach 1.5
0 10 20 30 40
Data accessed on 15 Nov 2015.
a Includes anal cancer (C21).
b Includes HIV disease resulting in malignant neoplasms (B21).
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 10: Comparison of the ten most frequent cancers in women aged 15-44 years by World and
continents (estimates for 2012)
World Asia
Breast 21.8 Breast 18.8
0 10 20 30 40 0 10 20 30 40
Africa Europe
Breast 20.3 Breast 35.0
0 10 20 30 40 0 10 20 30 40
Americas Oceania
Breast 27.2 Breast 37.2
0 10 20 30 40 0 10 20 30 40
Figure 11: Age-specific incidence of cervical cancer by World, developed and developing regions
and five continents
World Asia
Africa Europe
Americas Oceania
Agespecific rates of cervical cancer per 100,000
100
75
50
25
0
19 024 529 034 539 044 549 054 559 064 569 074 >=75
15 2 2 3 3 4 4 5 5 6 6 7
Age group (years)
Data accessed on 15 Nov 2015.
Rates per 100,000 women per year.
Data sources: Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality
Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 12: Annual number of new cases of cervical cancer by age group in developing and developed
regions and five continents World (estimates for 2012)
350000
323619*
315000
280000
245000
210000
175000
140000
111503*
105000 92337*
70000
35000
0
1539 4064 65+
FIVE CONTINENTS
Asia Americas Oceania
Africa Europe
Annual number of new cases of cervical cancer
350000
323619*
315000
280000
245000
210000
175000
140000
111503*
105000 92337*
70000
35000
0
1539 4064 65+
* Less developed regions 15-39 years: 91746 cases. 40-64 years: 278880 cases. 65+ years: 73762 cases.
* More developed regions 15-39 years: 19757 cases. 40-64 years: 44739 cases. 65+ years: 18575 cases.
* Asia 15-39 years: 55178 cases. 40-64 years: 188892 cases. 65+ years: 40668 cases.
* Africa 15-39 years: 19650 cases. 40-64 years: 58316 cases. 65+ years: 21014 cases.
* Americas 15-39 years: 22725 cases. 40-64 years: 42915 cases. 65+ years: 17537 cases.
* Europe 15-39 years: 13249 cases. 40-64 years: 32345 cases. 65+ years: 12775 cases.
* Oceania 15-39 years: 701 cases. 40-64 years: 1151 cases. 65+ years: 343 cases.
Figure 13: Annual number of cases and age-specific incidence rates of cervical cancer in the World and
its regions (estimates for 2012)
World Africa
Agespecific rates of
cervical cancer(a)
90 90
60 60
30
30
0
0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
324000 323619* 190000
270000
Annual number of cases
152000
of cervical cancer
216000
114000
162000
111503* 76000
108000 92337 58316*
54000 38000
19637* 21014
0 0
1539 4064 65+ 1539 4064 65+
* World 15-19 yrs: 754 cases. 20-24 yrs: 6445 cases. 25-29 yrs: 19167 cases. 30-34 yrs: 34149 cases. 35-39 yrs: 50988 cases. 40-44 yrs: 66308 cases. 45-49 yrs: 73307 cases. 50-54 yrs: 71492
cases. 55-59 yrs: 63571 cases. 60-64 yrs: 48941 cases.
* Africa 15-19 yrs: 352 cases. 20-24 yrs: 1091 cases. 25-29 yrs: 3310 cases. 30-34 yrs: 6198 cases. 35-39 yrs: 8686 cases. 40-44 yrs: 10474 cases. 45-49 yrs: 11987 cases. 50-54 yrs: 12753
cases. 55-59 yrs: 12342 cases. 60-64 yrs: 10760 cases.
Figure 14: Annual number of cases and age-specific incidence rates of cervical cancer in the World and
its regions (estimates for 2012) (Continued)
Americas Europe
Agespecific rates of
cervical cancer(a)
90 90
60 60
30
30
0
0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
190000 190000
Annual number of cases
152000 152000
of cervical cancer
114000 114000
76000 76000
42915*
38000 38000 32345*
22679* 17537 13242* 12775
0 0
1539 4064 65+ 1539 4064 65+
Asia Oceania
Agespecific rates of
cervical cancer(a)
90 90
60 60
30
30
0
0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
152000 152000
of cervical cancer
114000 114000
76000 76000
55178*
40668
38000 38000
* Americas 15-19 yrs: 180 cases. 20-24 yrs: 2047 cases. 25-29 yrs: 4668 cases. 30-34 yrs: 6901 cases. 35-39 yrs: 8883 cases. 40-44 yrs: 9817 cases. 45-49 yrs: 9862 cases. 50-54 yrs: 8951
cases. 55-59 yrs: 7771 cases. 60-64 yrs: 6514 cases.
* Asia 15-19 yrs: 195 cases. 20-24 yrs: 2443 cases. 25-29 yrs: 8394 cases. 30-34 yrs: 16585 cases. 35-39 yrs: 27561 cases. 40-44 yrs: 39251 cases. 45-49 yrs: 44160 cases. 50-54 yrs: 42416
cases. 55-59 yrs: 36759 cases. 60-64 yrs: 26306 cases.
* Europe 15-19 yrs: 22 cases. 20-24 yrs: 798 cases. 25-29 yrs: 2639 cases. 30-34 yrs: 4235 cases. 35-39 yrs: 5548 cases. 40-44 yrs: 6449 cases. 45-49 yrs: 7020 cases. 50-54 yrs: 7137 cases.
55-59 yrs: 6518 cases. 60-64 yrs: 5221 cases.
* Oceania 15-19 yrs: 4 cases. 20-24 yrs: 60 cases. 25-29 yrs: 144 cases. 30-34 yrs: 208 cases. 35-39 yrs: 280 cases. 40-44 yrs: 317 cases. 45-49 yrs: 278 cases. 50-54 yrs: 235 cases. 55-59 yrs:
181 cases. 60-64 yrs: 140 cases.
NOTE.
For time trends in cervical cancer incidence, please refer to individual country data.
3.1.2 Mortality
KEY STATS.
Cervical cancer is the 2nd most common female cancer deaths in women
aged 15 to 44 years in the World.
* Ranking of cervical cancer incidence to other cancers among all women according to highest incidence rates (ranking 1st). Ranking is based on crude incidence rates (actual number of
cervical cancer cases). Ranking using age-standardized rate (ASR) may differ.
Figure 15: Age-standardised mortality rates of cervical cancer in the World (estimates for 2012)
Table 6: Cervical cancer mortality by World region and sub regions (estimates for 2012)
Cumulative risk (%) Ranking of CC
Area N cases Crude ratea ASRa ages 0-74 yearsb All women Women 15-44 years
World 265,672 7.6 6.8 0.8 4 2
Less developed re- 230,158 8.1 8.3 0.9 3 2
gions
More developed re- 35,514 5.6 3.3 0.3 9 2
gions
Africa 60,098 11.2 17.5 2.0 2 2
Eastern Africa 28,197 15.9 27.6 3.1 1 1
Middle Africa 7,917 11.8 22.2 2.6 1 2
Northern Africa 2,717 2.6 3.2 0.4 8 8
Southern Africa 4,721 16.0 17.9 1.9 1 1
Western Africa 16,546 10.4 18.5 2.1 2 2
Americas 35,673 7.4 5.9 0.6 5 2
Caribbean 2,254 10.6 8.6 0.9 4 2
Central America 6,937 8.5 8.9 1.0 2 1
Northern America 7,108 4.0 2.6 0.3 11 2
South America 19,374 9.5 8.6 0.9 3 2
Asia 144,434 7.0 6.4 0.7 6 2
Central Asia 2,286 7.2 7.7 0.8 3 2
Eastern Asia 36,320 4.7 3.3 0.3 8 2
Southern Asia 79,958 9.4 11.0 1.2 2 2
South-Eastern 23,989 7.9 7.9 0.9 3 2
Asia
Western Asia 1,881 1.6 1.9 0.2 11 9
Europe 24,404 6.4 3.8 0.4 7 2
Eastern Europe 15,436 9.9 6.2 0.6 7 1
Northern Europe 1,963 3.9 2.2 0.2 16 2
Southern Europe 3,526 4.4 2.4 0.2 13 3
Western Europe 3,479 3.6 1.8 0.2 15 4
Oceania 1,063 5.6 4.5 0.5 6 2
Australia & New 357 2.6 1.5 0.2 17 5
Zealand
Melanesia 684 15.3 20.7 2.2 1 1
Micronesia 6 2.2 2.7 0.4 5 12
Polynesia 16 4.8 5.1 0.6 4 2
Data accessed on 15 Nov 2015.
Standardised rates have ben estimated using the direct method and the World population as the reference.
Ranking of cervical cancer mortality to other cancers among all women ages 15-44 years according to highest mortality rates (ranking 1st). Ranking is based on crude mortality rates(actual
number of cervical cancer deaths). Ranking using AST may differ.
a Rates per 100,000 women per year.
b Cumulative risk (mortality) is the probability or risk of individuals dying from the disease during ages 0-74 years. For cancer, it is expressed as the % of new born children who would be
expected to die from a particular cancer before the age of 75 if they had the rates of cancer observed in the period in the absence of competing causes.
Data sources:
1 Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 16: Ranking of cervical cancer versus other cancers among all women and women aged 15-44
years, according to mortality rates in the World (estimates for 2012)
Figure 17: World age-standardised mortality rates of cervical cancer by World and sub regions World
(estimates for 2012)
World, developed and developing regions Continental subregions
Less developed 8.3
Eastern Africa 27.6
Middle Africa 22.2
Melanesia 20.7
Western Africa 18.5
0 10 20 0 10 20 30
Figure 18: Comparison of the ten most frequent cancer deaths in all women in the World compared to
developing and developed regions (estimates for 2012)
0 5 10 15 20 25 0 5 10 15 20 25
0 5 10 15 20 25
Data accessed on 15 Nov 2015.
a Includes anal cancer (C21).
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 19: Comparison of the ten most frequent cancer deaths in all women in the World compared to
the continents (estimations for 2012)
World Asia
Breast 12.9 Lung 11.0
0 5 10 15 20 25 0 5 10 15 20 25
Africa Europe
Cervix uteri 17.5 Breast 16.1
0 5 10 15 20 25 0 5 10 15 20 25
Americas Oceania
Lung 15.9 Breast 15.6
0 5 10 15 20 25 0 5 10 15 20 25
Figure 20: Comparison of the ten most frequent cancer deaths in women aged 15-44 years by World,
developing and developed regions (estimates for 2012)
0 5 10 15 0 5 10 15
Leukaemia 1.6
Colorectum(a) 1.1
Liver 1.1
Ovary 1.1
Stomach 1.1
Lung 0.9
0 5 10 15
Data accessed on 15 Nov 2015.
a Includes anal cancer (C21).
b Includes HIV disease resulting in malignant neoplasms (B21).
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 21: Comparison of the ten most frequent cancer deaths in women aged 15-44 years by World
and continents (estimates for 2012)
World Asia
Breast 5.4 Breast 5.0
0 5 10 15 0 5 10 15
Africa Europe
Breast 8.8 Breast 4.4
0 5 10 15 0 5 10 15
Americas Oceania
Breast 4.0 Breast 5.6
0 5 10 15 0 5 10 15
World Asia
Africa Europe
Americas Oceania
Agespecific mortality rates of cervical cancer per 100,000
100
80
60
40
20
0
19 024 529 034 539 044 549 054 559 064 569 074 >=75
15 2 2 3 3 4 4 5 5 6 6 7
Age group (years)
Data accessed on 15 Nov 2015.
Rates per 100,000 women per year.
Data sources: Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality
Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 23: Annual number of deaths of cervical cancer by age group by developing and developed regions
and continents (estimates for 2012)
200000
180000
160000 151872*
140000
120000
100000
85534*
80000
60000
40000 28201*
20000
0
1539 4064 65+
FIVE CONTINENTS
Asia Americas Oceania
Africa Europe
Annual number of cervical cancer deaths
200000
180000
160000 151872*
140000
120000
100000
85534*
80000
60000
40000 28201*
20000
0
1539 4064 65+
* Less developed regions 15-39 years: 25130 cases. 40-64 years: 134922 cases. 65+ years: 70041 cases.
* More developed regions 15-39 years: 3071 cases. 40-64 years: 16950 cases. 65+ years: 15493 cases.
* Asia 15-39 years: 13567 cases. 40-64 years: 88208 cases. 65+ years: 42647 cases.
* Africa 15-39 years: 8065 cases. 40-64 years: 33320 cases. 65+ years: 18669 cases.
* Americas 15-39 years: 4168 cases. 40-64 years: 18020 cases. 65+ years: 13476 cases.
* Europe 15-39 years: 2212 cases. 40-64 years: 11779 cases. 65+ years: 10413 cases.
* Oceania 15-39 years: 189 cases. 40-64 years: 545 cases. 65+ years: 329 cases.
Figure 24: Annual number of deaths and age-specific mortality rates of cervical cancer in the World and
its regions (estimates for 2012)
World Africa
Agespecific rates of
cervical cancer(a)
90 90
75 75
60 60
45 45
30
30
15
15
0
0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
156000 151872*
144000 84000
Annual number of deaths
132000
120000 72000
of cervical cancer
108000
60000
96000
85534
84000 48000
72000
60000 36000 33320*
48000
36000 24000 18669
28201*
24000 12000 8060*
12000
0 0
1539 4064 65+ 1539 4064 65+
World 15-19 yrs: 314 cases. 20-24 yrs: 1101 cases. 25-29 yrs: 3654 cases. 30-34 yrs: 8158 cases. 35-39 yrs: 14974 cases. 40-44 yrs: 22872 cases. 45-49 yrs: 30105 cases. 50-54 yrs: 33939
cases. 55-59 yrs: 34263 cases. 60-64 yrs: 30693 cases. Africa 15-19 yrs: 265 cases. 20-24 yrs: 553 cases. 25-29 yrs: 1331 cases. 30-34 yrs: 2360 cases. 35-39 yrs: 3551 cases. 40-44 yrs: 4707
cases. 45-49 yrs: 6021 cases. 50-54 yrs: 7190 cases. 55-59 yrs: 7801 cases. 60-64 yrs: 7601 cases.
Data accessed on 15 Nov 2015.
a Rates per 100,000 women per year.
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 25: Annual number of deaths and age-specific mortality rates of cervical cancer in the World and
its regions (estimates for 2012) (Continued)
Americas Europe
Agespecific rates of
cervical cancer(a)
90 90
75 75
60 60
45 45
30 30
15
15
0
0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
84000 84000
Annual number of deaths
72000 72000
of cervical cancer
60000 60000
48000 48000
36000 36000
24000 24000
18020*
13476 11779* 10413
12000 12000
4161* 2212*
0 0
1539 4064 65+ 1539 4064 65+
Asia Oceania
Agespecific rates of
cervical cancer(a)
90 90
75 75
60 60
45 45
30 30
15
15
0
0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
75+
88208*
84000 84000
Annual number of deaths
72000 72000
of cervical cancer
60000 60000
48000 42647 48000
36000 36000
24000 24000
13567*
12000 12000
0 0 189* 545* 329
1539 4064 65+ 1539 4064 65+
Americas 15-19 yrs: 12 cases. 20-24 yrs: 137 cases. 25-29 yrs: 620 cases. 30-34 yrs: 1325 cases. 35-39 yrs: 2067 cases. 40-44 yrs: 2852 cases. 45-49 yrs: 3629 cases. 50-54 yrs: 3997 cases.
55-59 yrs: 3944 cases. 60-64 yrs: 3598 cases. Asia 15-19 yrs: 34 cases. 20-24 yrs: 363 cases. 25-29 yrs: 1333 cases. 30-34 yrs: 3699 cases. 35-39 yrs: 8138 cases. 40-44 yrs: 13641 cases. 45-49
yrs: 18256 cases. 50-54 yrs: 19983 cases. 55-59 yrs: 19563 cases. 60-64 yrs: 16765 cases. Europe 15-19 yrs: 2 cases. 20-24 yrs: 32 cases. 25-29 yrs: 332 cases. 30-34 yrs: 715 cases. 35-39
yrs: 1131 cases. 40-44 yrs: 1565 cases. 45-49 yrs: 2088 cases. 50-54 yrs: 2647 cases. 55-59 yrs: 2850 cases. 60-64 yrs: 2629 cases. Oceania 15-19 yrs: 1 cases. 20-24 yrs: 16 cases. 25-29 yrs:
36 cases. 30-34 yrs: 56 cases. 35-39 yrs: 80 cases. 40-44 yrs: 107 cases. 45-49 yrs: 111 cases. 50-54 yrs: 122 cases. 55-59 yrs: 105 cases. 60-64 yrs: 100 cases.
Data accessed on 15 Nov 2015.
a Rates per 100,000 women per year.
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Figure 26: Age-specific incidence and mortality rates of cervical cancer in the World and its regions
(estimates for 2012)
Africa Europe
110 110
100 100
90 90
80 80
70 70
60 60
50 50
40 40
30 30
20 20
10 10
0 0
of cervical cancer per 100,000
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
>=75
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
>=75
Agespecific rates
110
Americas 110
Oceania
100 100
90 90
80 80
70 70
60 60
50 50
40 40
30 30
20 20
10 10
0 0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
>=75
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
>=75
110
Asia
100
90
80
70
60
50
40
30
20
10
0
1519
2024
2529
3034
3539
4044
4549
5054
5559
6064
6569
7074
>=75
Incidence Mortality
Data accessed on 15 Nov 2015.
Rates per 100,000 women per year.
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Anal cancer is rare in the general population with an average worldwide incidence of 1 per 100,000,
but is reported to be increasing in more developed regions. Globally, there are an estimated 27,000 new
cases every year (de Martel C et al. Lancet Oncol 2012;13(6):607-15). Women have higher incidences of
anal cancer than men. Incidence is particularly high among populations of men who have sex with men
(MSM), women with history of cervical or vulvar cancer, and immunosuppressed populations, including
those who are HIV-infected and patients with a history of organ transplantation. These cancers are
predominantly squamous cell carcinoma, adenocarcinomas, or basaloid and cloacogenic carcinomas.
NOTE.
For time trends in anal cancer incidence please refer to individual country data.
Cancer of the vulva is rare among women worldwide, with an estimated 27,000 new cases in 2008, rep-
resenting 4% of all gynaecologic cancers (de Martel C et al. Lancet Oncol 2012;13(6):607-15). Worldwide,
about 60% of all vulvar cancer cases occur in more developed countries. Vulvar cancer has two distinct
histological patterns with two different risk factor profiles: (1) basaloid/warty types (2) keratinizing
types. Basaloid/warty lesions are more common in young women, are very often associated with HPV
DNA detection (75-100%), and have a similar risk factor profile as cervical cancer. Keratinizing vulvar
carcinomas represent the majority of the vulvar lesions (>60%), they occur more often in older women
and are more rarely associated with HPV (IARC Monograph Vol 100B)
NOTE.
For time trends in vulvar cancer incidence, please refer to individual country data.
Cancer of the vagina is a rare cancer, with an estimated 13,000 new cases in 2008, representing 2% of
all gynaecologic cancers (de Martel C et al. Lancet Oncol 2012;13(6):607-15). Although unreported and
similar to cervical cancer, the majority of vaginal cancer cases (68%) occur in less developed countries.
Most vaginal cancers are squamous cell carcinoma (90%) generally attributable to HPV, followed by
clear cell adenocarcinomas and melanoma. Metastatic cervical cancer can be misclassified as cancer of
the vagina. Invasive vaginal cancer is diagnosed primarily in old women (>=65 years) and the diagnosis
is rare in women under 45 years whereas the peak incidence of carcinoma in situ is observed between
ages 55 and 70 (Vaccine 2008, Vol. 26, Suppl 10)
NOTE.
For time trends in vaginal cancer incidence, please refer to individual country data.
The annual burden of penile cancer has been estimated to be 22,000 cases worldwide with incidence
rates strongly correlating with those of cervical cancer (de Martel C et al. Lancet Oncol 2012;13(6):607-
15). Penile cancer is rare and most commonly affects men aged 50-70 years. Incidence rates are higher
in less developed countries than in more developed countries, accounting for up to 10% of male cancers
in some parts of Africa, South America and Asia. Precursor cancerous penile lesions (PeIN) are rare.
Cancers of the penis are primarily of squamous cell carcinomas (SCC) (95%) and the most common
penile SCC histologic sub-types are keratinising (49%), mixed warty-basaloid (17%), verrucous (8%)
warty (6%), and basaloid (4%). HPV is most commonly detected in basaloid and warty tumours but is
less common in keratinising and verrucous tumours. Approximately 60-100% of PeIN lesions are HPV
DNA positive.
NOTE.
For time trends in penile cancer incidence, please refer to individual country data.
Table 11: Cancer incidence of pharynx (excluding nasopharynx) by sex, in the World and its regions.
Includes ICD-10 codes: C09-10, C12-14 (estimates for 2012).
MALE FEMALE
Area N cases Crudea ASRa Cum riskb N cases Crudea ASRa Cum riskb
rate (%) ages rate (%) ages
0-74 0-74
World 115131 3.2 3.2 0.4 27256 0. 8 0.7 0.1
Less developed regions 70731 2.4 2.8 0.3 18059 0. 6 0.7 0.1
More developed regions 44400 7.3 4.7 0.6 9197 1. 4 0.8 0.1
Africa 3369 0.6 1.1 0.1 1928 0. 4 0.6 0.1
Eastern Africa 906 0.5 1.0 0.1 567 0. 3 0.6 0.1
Middle Africa 585 0.9 1.7 0.2 208 0. 3 0.6 0.1
Northern Africa 621 0.6 0.8 0.1 611 0. 6 0.7 0.1
Southern Africa 784 2.7 3.9 0.5 392 1. 3 1.5 0.2
Western Africa 473 0.3 0.6 0.1 150 0. 1 0.1 0.0
Americas 17637 3.7 3.3 0.4 4471 0. 9 0.7 0.1
Caribbean 815 3.9 3.6 0.4 227 1. 1 0.9 0.1
Central America 694 0.9 1.0 0.1 218 0. 3 0.3 0.0
Northern America 10493 6.1 4.2 0.5 2756 1. 6 1.0 0.1
South America 5635 2.8 3.0 0.3 1270 0. 6 0.5 0.1
Asia 65016 3.0 3.1 0.4 14997 0. 7 0.7 0.1
Central Asia 717 2.3 3.2 0.4 321 1. 0 1.1 0.1
Eastern Asia 13441 1.6 1.3 0.1 1884 0. 2 0.2 0.0
Southern Asia 43190 4.8 6.3 0.8 10454 1. 2 1.5 0.2
South-Eastern Asia 6933 2.3 2.6 0.3 1965 0. 6 0.7 0.1
Western Asia 735 0.6 0.8 0.1 373 0. 3 0.4 0.0
Europe 28394 7.9 5.2 0.6 5700 1. 5 0.9 0.1
Eastern Europe 10187 7.4 5.3 0.6 1401 0. 9 0.5 0.1
Northern Europe 2594 5.3 3.4 0.4 844 1. 7 1.0 0.1
Southern Europe 4137 5.3 3.4 0.4 731 0. 9 0.5 0.1
Western Europe 11476 12.3 7.5 0.9 2724 2. 8 1.6 0.2
Oceania 715 3.8 3.0 0.4 160 0. 8 0.6 0.1
Australia & New Zealand 633 4.6 3.2 0.4 146 1. 1 0.7 0.1
Melanesia 71 1.5 3.4 0.6 14 0. 3 0.4 0.0
Micronesia 0 0.0 0.0 0.0 0 0. 0 0.0 0.0
Polynesia 11 3.2 3.8 0.5 0 0. 0 0.0 0.0
Data accessed on 15 Nov 2015.
a Male: Rates per 100,000 men per year. Female: Rates per 100,000 women per year.
b Cumulative risk (incidence) is the probability or risk of individuals getting from the disease during ages 0-74 years. For cancer, it is expressed as the % of new born children who would be
expected to develop from a particular cancer before the age of 75 if they had the rates of cancer observed in the period in the absence of competing causes.
Data sources:
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.2, Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Table 12: Cancer mortality of pharynx (excluding nasopharynx) by sex, in the World and its regions.
Includes ICD-10 codes: C09-10, C12-14 (estimates for 2012).
MALE FEMALE
Area N cases Crudea ASRa Cum riskb N cases Crudea ASRa Cum riskb
rate (%) ages rate (%) ages
0-74 0-74
World 77585 2.2 2.2 0.3 18505 0. 5 0.5 0.1
Figure 27: Comparison of cancer incidence and mortality of pharynx (excluding nasopharynx) by sex
and age group in the World. Includes ICD-10 codes: C09-10,C12-14 (estimates for 2012)
MALE
25 World 25 Less developed regions 25 More developed regions
20 20 20
pharyngeal cancer (excluding nasopharynx) per 100,000
15 15 15
10 10 10
5 5 5
Agespecific rates of
0 0 0
014
1539
4044
4549
5054
5559
6064
6569
7074
>=75
014
1539
4044
4549
5054
5559
6064
6569
7074
>=75
014
1539
4044
4549
5054
5559
6064
6569
7074
>=75
FEMALE
25 World 25 Less developed regions 25 More developed regions
20 20 20
15 15 15
10 10 10
5 5 5
0 0 0
014
1539
4044
4549
5054
5559
6064
6569
7074
>=75
014
1539
4044
4549
5054
5559
6064
6569
7074
>=75
014
1539
4044
4549
5054
5559
6064
6569
7074
>=75
Incidence Mortality
Figure 28: Comparison of cancer incidence and mortality of pharynx (excluding nasopharynx) in males
by age group in the World and its regions. . Includes ICD-10 codes: C09-10,C12-14 (estimates for 2012)
30 World 30 Asia
25 25
20 20
15 15
10 10
5 5
0 0
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
7
7
1
1
3
6
5
5
6
6
4
4
0
0
>=
>=
pharyngeal cancer (excluding nasopharynx) per 100,000
30 Africa 30 Europe
25 25
20 20
Agespecific rates of
15 15
10 10
5 5
0 0
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
7
7
1
1
3
6
5
5
6
6
4
4
0
0
>=
>=
30 Americas 30 Oceania
25 25
20 20
15 15
10 10
5 5
0 0
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
7
7
1
1
3
6
5
5
6
6
4
4
0
0
>=
>=
Incidence Mortality
Figure 29: Comparison of cancer incidence and mortality of pharynx (excluding nasopharynx) in females
by age group in the World and its regions. . Includes ICD-10 codes: C09-10,C12-14 (estimates for 2012)
5 World 5 Asia
4 4
3 3
2 2
1 1
0 0
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
7
7
1
1
3
6
5
5
6
6
4
4
0
0
>=
>=
pharyngeal cancer (excluding nasopharynx) per 100,000
5 Africa 5 Europe
4 4
3 3
Agespecific rates of
2 2
1 1
0 0
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
7
7
1
1
3
6
5
5
6
6
4
4
0
0
>=
>=
5 Americas 5 Oceania
4 4
3 3
2 2
1 1
0 0
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
15 4
40 9
45 4
50 9
55 4
60 9
65 4
70 9
4
75
7
7
1
1
3
6
5
5
6
6
4
4
0
0
>=
>=
Incidence Mortality
4.1 HPV burden in women with normal cervical cytology, cervical precancerous
lesions or invasive cervical cancer
The statistics shown in this section focus on HPV infection in the cervix uteri. HPV cervical infection re-
sults in cervical morphological lesions ranging from normalcy (cytologically normal women) to different
stages of precancerous lesions (CIN-1, CIN-2, CIN-3/CIS) and invasive cervical cancer. HPV infection
is measured by means of HPV DNA detection in cervical cells (fresh tissue, paraffin embedded or exfo-
liated cells).
The prevalence of HPV increases with severity of the lesion. HPV causes virtually 100% of cases of
cervical cancer, and an underestimation of HPV prevalence in cervical cancer is most likely due to the
limitations of study methodologies. Worldwide, HPV-16 and 18, the two vaccine-preventable types. con-
tribute to over 70% of all cervical cancer cases, between 41%-67% of high-grade cervical lesions and
16-32% of low-grade cervical lesions. After HPV-16/18, the six most common HPV types are the same
in all world regions, namely 31, 33, 35, 45, 52 and 58; these account for an additional 20% of cervical
cancers worldwide (Clifford G et al. Vaccine 2006;24(S3):26-34).
Figure 30: Prevalence of HPV among women with normal cervical cytology in the World
Figure 31: Crude age-specific HPV prevalence (%) and 95% confidence interval in women with normal
cervical cytology in the World and its regions
HPV prevalence (%)
50 Europe 50 Oceania
45 45
40 40
35 35
30 30
25 25
20 20
15 15
10 10
5 5
0 0
<25 2534 3544 4554 5564 65+ <25 2534 3544 4554 5564 65+
HPV prevalence (%)
50 Africa 50 Asia
45 45
40 40
35 35
30 30
25 25
20 20
15 15
10 10
5 5
0 0
<25 2534 3544 4554 5564 65+ <25 2534 3544 4554 5564 65+
HPV prevalence (%)
50 Americas 50 World
45 45
40 40
35 35
30 30
25 25
20 20
15 15
10 10
5 5
0 0
<25 2534 3544 4554 5564 65+ <25 2534 3544 4554 5564 65+
Figure 32: Prevalence of HPV among women with normal cervical cytology in Africa by country and
study
Figure 33: Prevalence of HPV among women with normal cervical cytology in Africa by country and
study (continued)
Figure 34: Prevalence of HPV among women with normal cervical cytology in the Americas by country
and study
Figure 35: Prevalence of HPV among women with normal cervical cytology in the Americas by country
and study (continued)
Figure 36: Prevalence of HPV among women with normal cervical cytology in the Americas by country
and study (continued)
Figure 37: Prevalence of HPV among women with normal cervical cytology in the Americas by country
and study (continued)
Figure 38: Prevalence of HPV among women with normal cervical cytology in Asia by country and study
Figure 39: Prevalence of HPV among women with normal cervical cytology in Asia by country and study
(continued)
Figure 40: Prevalence of HPV among women with normal cervical cytology in Asia by country and study
(continued)
Figure 41: Prevalence of HPV among women with normal cervical cytology in Asia by country and study
(continued)
Figure 42: Prevalence of HPV among women with normal cervical cytology in Asia by country and study
(continued)
Figure 43: Prevalence of HPV among women with normal cervical cytology in Asia by country and study
(continued)
0% 10%
Figure 44: Prevalence of HPV among women with normal cervical cytology in Europe by country and
study
Figure 45: Prevalence of HPV among women with normal cervical cytology in Europe by country and
study (continued)
Figure 46: Prevalence of HPV among women with normal cervical cytology in Europe by country and
study (continued)
Figure 47: Prevalence of HPV among women with normal cervical cytology in Europe by country and
study (continued)
Figure 48: Prevalence of HPV among women with normal cervical cytology in Oceania by country and
study
4.1.2 HPV type distribution among women with normal cervical cytology, precancerous cer-
vical lesions and cervical cancer
Table 13: Prevalence of HPV 16/18 in women with normal cervical cytology, precancerous cervical le-
sions and invasive cervical cancer by World region and sub-regions
Normal cytology Low-grade lesions High-grade lesions Cervical cancer
Country /Region No. HPV Prev No. HPV Prev No. HPV Prev No. HPV Prev
tested (95% CI) tested (95% CI) tested (95% CI) tested (95% CI)
World 514,928 4.1 (4.0-4.2) 38,394 25.7 (25.3-26.1) 50,475 51.8 (51.4-52.2) 59,149 69.4 (69.0-69.8)
Less developed regions 177,536 4.4 (4.3-4.5) 9,864 25.0 (24.1-25.9) 13,668 46.6 (45.8-47.4) 25,364 69.5 (68.9-70.1)
More developed regions 334,356 3.9 (3.8-4.0) 28,530 25.9 (25.4-26.4) 33,704 54.1 (53.6-54.6) 25,245 71.8 (71.2-72.4)
Africa 20,672 3.7 (3.5-4.0) 620 22.7 (19.6-26.2) 540 38.5 (34.5-42.7) 3,890 67.2 (65.7-68.7)
Eastern Africa 4,298 4.8 (4.2-5.5) 151 29.8 (23.1-37.5) 164 43.9 (36.5-51.6) 1,359 68.1 (65.5-70.5)
Middle Africa - -- 24 12.5 (4.3-31.0) 38 34.2 (21.2-50.1) - --
Northern Africa 2,987 2.7 (2.2-3.4) 27 18.5 (8.2-36.7) 11 45.5 (21.3-72.0) 673 78.8 (75.5-81.7)
Southern Africa 8,661 3.2 (2.8-3.6) 57 21.1 (12.5-33.3) 115 34.8 (26.7-43.9) 810 62.2 (58.8-65.5)
Western Africa 4,726 4.3 (3.8-4.9) 361 21.1 (17.2-25.6) 212 36.8 (30.6-43.5) 945 55.3 (52.2-58.5)
Americas 110,268 5.4 (5.3-5.5) 9,909 26.7 (25.8-27.6) 13,624 56.8 (56.0-57.6) 10,105 68.3 (67.4-69.2)
Caribbean 323 15.8 (12.2-20.2) 263 7.6 (5.0-11.5) 294 33.7 (28.5-39.3) 137 60.6 (52.2-68.4)
Central America 18,421 4.7 (4.4-5.0) 1,424 15.0 (13.3-17.0) 559 40.8 (36.8-44.9) 2,913 63.1 (61.3-64.8)
Northern America 77,952 4.4 (4.3-4.5) 6,022 27.1 (26.0-28.2) 10,247 58.6 (57.6-59.6) 3,723 71.3 (69.8-72.7)
South America 13,771 12.1 (11.6-12.7) 2,200 35.5 (33.5-37.5) 2,524 56.3 (54.4-58.2) 6,286 62.7 (61.5-63.9)
Asia 145,664 3.4 (3.3-3.5) 7,972 21.2 (20.3-22.1) 13,530 42.3 (41.5-43.1) 20,858 68.9 (68.3-69.5)
Central Asia - -- - -- - -- - --
Eastern Asia 116,022 3.2 (3.1-3.3) 6,990 20.3 (19.4-21.3) 10,574 41.0 (40.1-41.9) 15,293 65.0 (64.2-65.7)
South-Eastern Asia 8,755 3.0 (2.7-3.4) 474 27.4 (23.6-31.6) 1,067 33.3 (30.5-36.2) 3,134 71.6 (70.0-73.2)
Southern Asia 14,520 4.4 (4.1-4.7) 229 30.1 (24.6-36.4) 319 64.6 (59.2-69.6) 2,780 80.3 (78.8-81.7)
Western Asia 6,367 2.3 (2.0-2.7) 279 24.0 (19.4-29.4) 1,570 52.1 (49.6-54.6) 936 72.4 (69.5-75.2)
Europe 232,291 3.8 (3.7-3.9) 19,420 27.1 (26.5-27.7) 21,152 54.5 (53.8-55.2) 18,508 74.0 (73.4-74.6)
Eastern Europe 7,818 9.7 (9.1-10.4) 1,058 31.8 (29.0-34.6) 661 60.5 (56.7-64.2) 1,687 84.8 (83.0-86.5)
Northern Europe 119,652 4.5 (4.4-4.6) 4,949 30.6 (29.3-31.9) 8,448 54.9 (53.8-56.0) 5,956 76.9 (75.8-78.0)
Southern Europe 50,059 3.2 (3.0-3.4) 10,538 25.4 (24.6-26.2) 5,878 53.2 (51.9-54.5) 4,072 68.0 (66.6-69.4)
Western Europe 57,216 2.6 (2.5-2.7) 2,875 25.2 (23.7-26.8) 3,062 59.4 (57.7-61.1) 3,050 78.7 (77.2-80.1)
Oceania 2,997 8.3 (7.4-9.4) 473 27.1 (23.3-31.2) 1,629 59.1 (56.7-61.5) 855 76.6 (73.7-79.3)
Australia & New Zealand 2,271 8.5 (7.4-9.7) 473 27.1 (23.3-31.2) 1,517 58.4 (55.9-60.9) 785 76.1 (72.9-78.9)
Melanesia 726 7.7 (6.0-9.9) - -- 112 68.8 (59.7-76.6) 70 82.9 (72.4-89.9)
Micronesia - -- - -- - -- - --
Polynesia - -- - -- - -- - --
Data updated on 14 Dec 2016 (data as of 30 Jun 2014 / 30 Jun 2015).
95% CI: 95% Confidence Interval; High-grade lesions: CIN-2, CIN-3, CIS or HSIL; Low-grade lesions: LSIL or CIN-1;
Data sources: See references in Section 9.
Figure 49: Prevalence of HPV 16 among women with normal cervical cytology in Africa by country and
study
Figure 50: Prevalence of HPV 16 among women with normal cervical cytology in the Americas by
country and study
Figure 51: Prevalence of HPV 16 among women with normal cervical cytology in the Americas by
country and study (continued)
Figure 52: Prevalence of HPV 16 among women with normal cervical cytology in Asia by country and
study
Figure 53: Prevalence of HPV 16 among women with normal cervical cytology in Asia by country and
study (continued)
0% 10% 20%
Figure 54: Prevalence of HPV 16 among women with normal cervical cytology in Europe by country and
study
Figure 55: Prevalence of HPV 16 among women with normal cervical cytology in Europe by country and
study (continued)
Figure 56: Prevalence of HPV 16 among women with normal cervical cytology in Oceania by country
and study
0% 10%
Figure 57: Prevalence of HPV 16 among women with low-grade cervical lesions in Africa by country and
study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 58: Prevalence of HPV 16 among women with low-grade cervical lesions in the Americas by
country and study
Figure 59: Prevalence of HPV 16 among women with low-grade cervical lesions in the Americas by
country and study (continued)
Figure 60: Prevalence of HPV 16 among women with low-grade cervical lesions in Asia by country and
study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 61: Prevalence of HPV 16 among women with low-grade cervical lesions in Asia by country and
study (continued)
Figure 62: Prevalence of HPV 16 among women with low-grade cervical lesions in Europe by country
and study
Figure 63: Prevalence of HPV 16 among women with low-grade cervical lesions in Europe by country
and study (continued)
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 64: Prevalence of HPV 16 among women with low-grade cervical lesions in Oceania by country
and study
Figure 65: Prevalence of HPV 16 among women with high-grade cervical lesions in Africa by country
and study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 66: Prevalence of HPV 16 among women with high-grade cervical lesions in the Americas by
country and study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 67: Prevalence of HPV 16 among women with high-grade cervical lesions in the Americas by
country and study (continued)
Figure 68: Prevalence of HPV 16 among women with high-grade cervical lesions in Asia by country and
study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 69: Prevalence of HPV 16 among women with high-grade cervical lesions in Asia by country and
study (continued)
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 70: Prevalence of HPV 16 among women with high-grade cervical lesions in Europe by country
and study
10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 71: Prevalence of HPV 16 among women with high-grade cervical lesions in Europe by country
and study (continued)
10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 72: Prevalence of HPV 16 among women with high-grade cervical lesions in Oceania by country
and study
Figure 73: Prevalence of HPV 16 among women with invasive cervical cancer in Africa by country and
study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 74: Prevalence of HPV 16 among women with invasive cervical cancer in the Americas by country
and study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 75: Prevalence of HPV 16 among women with invasive cervical cancer in the Americas by country
and study (continued)
Figure 76: Prevalence of HPV 16 among women with invasive cervical cancer in Asia by country and
study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 77: Prevalence of HPV 16 among women with invasive cervical cancer in Asia by country and
study (continued)
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 78: Prevalence of HPV 16 among women with invasive cervical cancer in Asia by country and
study (continued)
Figure 79: Prevalence of HPV 16 among women with invasive cervical cancer in Europe by country and
study
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 80: Prevalence of HPV 16 among women with invasive cervical cancer in Europe by country and
study (continued)
10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 81: Prevalence of HPV 16 among women with invasive cervical cancer in Europe by country and
study (continued)
10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 82: Prevalence of HPV 16 among women with invasive cervical cancer in Oceania by country
and study
Figure 83: Comparison of the ten most frequent HPV oncogenic types among women with and without
cervical lesions by World compared to developing and developed regions
World Less developed regions More developed regions
53 18 52
18 1.2 53 1.0 31 1.4
70 1.1 31 1.0 18 1.1
51 1.1 70 1.0 70 1.1
66 1.0 33 1.0 66 1.1
58 1.0 51 0.7 39 1.0
39 0.9 68 0.7 56 0.9
31 18 53
53 7.3 33 5.9 52 8.4
66 6.9 51 4.8 66 7.8
58 6.7 66 4.5 56 7.4
18 6.5 53 4.4 18 6.5
56 6.5 31 4.1 39 5.9
39 5.3 56 4.0 58 5.7
58 18 33
33 7.3 31 6.3 18 7.3
18 6.8 33 6.3 58 7.0
51 5.7 51 4.0 51 6.9
53 3.5 53 3.1 39 4.1
35 3.3 66 2.3 35 4.0
39 3.3 45 2.3 53 3.7
33 58 45
58 3.9 52 4.0 58 3.7
31 3.5 33 3.8 31 3.7
52 3.5 31 3.4 52 3.2
35 1.7 59 2.0 35 1.4
39 1.5 35 2.0 39 1.4
59 1.4 39 1.5 51 1.0
0 20 40 60 0 20 40 60 0 20 40 60
Prevalence (%) Prevalence (%) Prevalence (%)
Figure 84: Comparison of the ten most frequent HPV types among women with invasive cervical cancer
by histology by World, developing and developed regions
World Less developed regions More developed regions
33 58 45
58 3.9 52 4.0 58 3.7
31 3.5 33 3.8 31 3.7
52 3.5 31 3.4 52 3.2
35 1.7 59 2.0 35 1.4
39 1.5 35 2.0 39 1.4
59 1.4 39 1.5 51 1.0
Squamous cell carcinoma
33 58 58
58 3.9 52 4.1 31 3.8
52 3.7 33 3.8 45 3.7
31 3.6 31 3.4 52 3.6
35 1.7 35 2.0 39 1.5
39 1.5 59 2.0 35 1.4
59 1.4 39 1.6 56 1.1
33 33 31
31 1.7 52 2.1 33 1.9
52 1.5 59 1.5 52 1.6
58 1.2 31 1.5 58 1.5
39 1.0 58 1.4 39 1.2
51 0.8 56 1.0 51 1.1
59 0.6 39 0.9 35 0.6
33 45 45
58 4.9 33 4.8 31 4.3
31 4.0 52 4.1 58 3.0
52 3.6 31 3.7 52 2.9
35 2.5 35 2.7 35 2.2
59 1.7 59 2.0 39 1.8
39 1.5 51 1.4 59 1.4
0 20 40 60 0 20 40 60 0 20 40 60
Prevalence (%) Prevalence (%) Prevalence (%)
Table 14: Type-specific HPV prevalence in women with normal cervical cytology, precancerous cervical
lesions and invasive cervical cancer
Normal cytology Low-grade lesions High-grade lesions Cervical cancer
HPV Type No. HPV Prev No. HPV Prev No. HPV Prev No. HPV Prev
tested % (95% CI) tested % (95% CI) tested % (95% CI) tested % (95% CI)
ONCOGENIC HPV TYPES
High-risk HPV types
16 514,928 2.9 (2.9-3.0) 38,380 19.2 (18.8-19.6) 50,475 45.0 (44.6-45.4) 59,149 55.1 (54.7-55.5)
18 503,242 1.2 (1.1-1.2) 37,942 6.5 (6.2-6.7) 50,008 6.8 (6.6-7.0) 58,724 14.3 (14.0-14.5)
31 473,568 1.3 (1.3-1.4) 36,373 7.6 (7.4-7.9) 48,783 10.4 (10.1-10.7) 52,732 3.5 (3.4-3.7)
33 471,894 0.7 (0.7-0.8) 35,933 4.7 (4.5-4.9) 48,812 7.3 (7.1-7.6) 54,130 4.2 (4.0-4.3)
35 452,480 0.5 (0.5-0.5) 31,275 3.0 (2.8-3.2) 44,924 3.3 (3.2-3.5) 47,883 1.7 (1.6-1.8)
39 445,908 0.9 (0.9-0.9) 29,012 5.3 (5.0-5.5) 43,949 3.3 (3.2-3.5) 46,640 1.5 (1.3-1.6)
45 453,127 0.8 (0.7-0.8) 31,476 3.2 (3.0-3.4) 45,018 3.0 (2.8-3.1) 47,305 5.0 (4.8-5.2)
51 442,755 1.1 (1.1-1.2) 27,464 8.7 (8.4-9.1) 44,091 5.7 (5.5-6.0) 44,908 1.0 (0.9-1.1)
52 452,302 1.5 (1.5-1.6) 29,335 8.8 (8.5-9.2) 44,947 11.0 (10.7-11.3) 50,242 3.5 (3.3-3.6)
56 449,467 0.8 (0.8-0.8) 28,721 6.5 (6.2-6.8) 43,352 2.5 (2.3-2.6) 46,261 1.0 (0.9-1.1)
58 462,570 1.0 (1.0-1.0) 30,408 6.7 (6.4-7.0) 45,019 8.1 (7.9-8.4) 51,078 3.9 (3.8-4.1)
59 437,025 0.7 (0.6-0.7) 27,234 3.8 (3.6-4.1) 41,754 2.1 (1.9-2.2) 46,937 1.4 (1.3-1.5)
Probable/possible carcinogen
26 182,611 0.1 (0.1-0.1) 14,114 0.5 (0.4-0.7) 22,823 0.6 (0.5-0.7) 29,645 0.3 (0.2-0.3)
30 58,319 0.2 (0.2-0.3) 3,971 0.5 (0.3-0.8) 2,746 0.3 (0.1-0.6) 14,868 0.3 (0.2-0.4)
34 129,047 0.1 (0.1-0.1) 8,077 0.3 (0.2-0.4) 12,751 0.1 (0.0-0.2) 21,904 0.1 (0.1-0.1)
53 309,365 1.3 (1.3-1.3) 23,456 7.3 (7.0-7.7) 33,387 3.5 (3.3-3.7) 34,132 0.5 (0.5-0.6)
66 374,745 1.0 (0.9-1.0) 26,982 6.9 (6.6-7.2) 39,598 2.6 (2.5-2.8) 40,335 0.4 (0.4-0.5)
67 156,556 0.4 (0.3-0.4) 11,115 1.7 (1.5-2.0) 18,576 0.9 (0.8-1.0) 22,826 0.3 (0.2-0.3)
68 434,494 0.6 (0.6-0.7) 25,794 2.8 (2.6-3.0) 37,961 1.9 (1.8-2.1) 40,411 0.8 (0.8-0.9)
69 150,267 0.1 (0.1-0.1) 11,367 0.3 (0.2-0.4) 19,824 0.3 (0.2-0.4) 20,431 0.2 (0.1-0.3)
70 237,308 1.1 (1.0-1.1) 17,543 2.0 (1.8-2.2) 25,811 1.3 (1.2-1.5) 33,216 0.2 (0.2-0.3)
73 183,558 0.4 (0.4-0.4) 16,756 2.2 (2.0-2.4) 23,546 1.6 (1.4-1.7) 29,094 0.5 (0.4-0.6)
82 206,140 0.3 (0.3-0.3) 16,491 1.5 (1.4-1.7) 25,975 1.9 (1.7-2.0) 30,357 0.2 (0.1-0.2)
85 81,113 0.1 (0.1-0.2) 3,806 0.3 (0.2-0.5) 7,951 0.2 (0.1-0.3) - -
97 1,751 3.1 (2.4-4.0) - - - - 781 0.1 (0.0-0.7)
NON-ONCOGENIC HPV TYPES
6 429,489 1.2 (1.1-1.2) 27,175 6.2 (5.9-6.5) 34,773 2.3 (2.2-2.5) 38,548 0.5 (0.4-0.6)
11 414,741 0.5 (0.4-0.5) 26,370 2.9 (2.7-3.1) 33,740 1.3 (1.2-1.5) 38,643 0.4 (0.4-0.5)
32 77,668 0.1 (0.1-0.2) 977 0.1 (0.0-0.6) - - 2,954 0.1 (0.0-0.2)
40 205,350 0.3 (0.3-0.3) 4,379 1.5 (1.2-1.9) 11,887 0.4 (0.3-0.5) 23,471 0.0 (0.0-0.0)
42 336,041 0.6 (0.6-0.6) 4,932 7.1 (6.4-7.8) 9,550 1.3 (1.1-1.6) 25,826 0.2 (0.2-0.3)
43 266,911 0.2 (0.2-0.2) 3,258 1.7 (1.3-2.2) 5,556 0.4 (0.3-0.6) 21,404 0.1 (0.0-0.1)
44 336,765 0.5 (0.5-0.5) 5,764 5.7 (5.1-6.3) 11,850 1.9 (1.7-2.2) 24,340 0.2 (0.2-0.3)
54 223,182 0.8 (0.8-0.9) 3,316 2.2 (1.8-2.8) 11,924 1.3 (1.1-1.5) 25,312 0.2 (0.2-0.3)
55 - - - - - - - -
57 63,790 0.0 (0.0-0.0) 1,021 0.2 (0.1-0.7) 2,194 0.3 (0.2-0.7) 6,821 0.0 (0.0-0.1)
61 155,276 0.9 (0.9-1.0) 3,183 1.8 (1.4-2.3) 9,040 1.2 (1.0-1.5) 23,743 0.3 (0.2-0.3)
62 123,056 1.4 (1.3-1.5) 2,713 4.2 (3.5-5.0) 8,244 1.6 (1.4-1.9) 7,093 0.4 (0.3-0.5)
64 - - - - - - - -
71 144,438 0.3 (0.3-0.3) 2,175 0.7 (0.5-1.2) 8,901 0.2 (0.2-0.4) 9,390 0.2 (0.1-0.3)
72 152,315 0.4 (0.4-0.4) 2,320 0.6 (0.3-1.0) 8,256 0.2 (0.2-0.4) 10,056 0.1 (0.1-0.2)
74 110,914 0.6 (0.6-0.7) 1,255 1.0 (0.6-1.8) 2,945 0.6 (0.4-1.0) 16,398 0.0 (0.0-0.1)
81 248,265 0.8 (0.7-0.8) 2,862 3.4 (2.8-4.1) 8,952 1.0 (0.8-1.2) 9,553 0.2 (0.1-0.3)
83 163,772 0.6 (0.5-0.6) 2,402 0.9 (0.6-1.3) 9,222 0.4 (0.3-0.6) 9,789 0.1 (0.1-0.2)
84 164,918 0.9 (0.8-0.9) 2,750 2.2 (1.7-2.8) 9,245 0.7 (0.6-0.9) 8,130 0.3 (0.2-0.5)
86 33,106 0.2 (0.1-0.2) - - - - - -
87 17,000 0.2 (0.2-0.3) 750 0.1 (0.0-0.8) - - - -
89 120,768 0.9 (0.8-0.9) 1,755 1.4 (0.9-2.0) 7,456 1.0 (0.8-1.2) 7,833 0.1 (0.1-0.3)
90 40,195 0.6 (0.5-0.7) 750 0.8 (0.4-1.7) - - 2,401 0.0 (0.0-0.2)
91 21,230 0.1 (0.1-0.2) 750 0.5 (0.2-1.4) - - 12,790 0.0 (0.0-0.1)
Data updated on 14 Dec 2016 (data as of 30 Jun 2014 / 30 Jun 2015).
95% CI: 95% Confidence Interval; High-grade lesions: CIN-2, CIN-3, CIS or HSIL; Low-grade lesions: LSIL or CIN-1;
a Kahng 2014 includes lesions CIN2 or worse
Data sources: See references in Section 9.
Table 15: Type-specific HPV prevalence among invasive cervical cancer cases by histology
Any Histology Squamous cell carcinoma Adenocarcinoma Unespecified
HPV Type No. HPV Prev No. HPV Prev No. HPV Prev No. HPV Prev
tested % (95% CI) tested % (95% CI) tested % (95% CI) tested % (95% CI)
ONCOGENIC HPV TYPES
High-risk HPV types
16 59,149 55.1 (54.7-55.5) 43,209 56.8 (56.4-57.3) 5,917 35.8 (34.6-37.1) 11,486 58.9 (58.0-59.8)
18 58,724 14.3 (14.0-14.5) 42,930 11.6 (11.3-11.9) 5,908 35.0 (33.7-36.2) 11,349 13.9 (13.3-14.6)
31 52,732 3.5 (3.4-3.7) 39,468 3.6 (3.4-3.8) 4,813 1.7 (1.4-2.1) 9,914 4.0 (3.6-4.4)
33 54,130 4.2 (4.0-4.3) 40,500 4.3 (4.1-4.5) 5,081 1.9 (1.5-2.3) 10,012 5.1 (4.7-5.5)
35 47,883 1.7 (1.6-1.8) 36,078 1.7 (1.5-1.8) 4,425 0.5 (0.4-0.8) 8,565 2.5 (2.2-2.9)
39 46,640 1.5 (1.3-1.6) 36,355 1.5 (1.4-1.6) 4,193 1.0 (0.7-1.3) 7,025 1.5 (1.2-1.8)
45 47,305 5.0 (4.8-5.2) 36,107 4.8 (4.6-5.0) 4,671 5.9 (5.3-6.6) 7,990 5.4 (4.9-5.9)
51 44,908 1.0 (0.9-1.1) 34,541 1.0 (0.9-1.1) 4,197 0.8 (0.6-1.1) 7,147 1.1 (0.9-1.4)
52 50,242 3.5 (3.3-3.6) 38,794 3.7 (3.5-3.9) 4,609 1.5 (1.1-1.8) 8,302 3.6 (3.2-4.0)
56 46,261 1.0 (0.9-1.1) 36,023 1.0 (0.9-1.1) 4,292 0.5 (0.3-0.7) 7,365 0.8 (0.7-1.1)
58 51,078 3.9 (3.8-4.1) 39,034 3.9 (3.8-4.1) 4,437 1.2 (0.9-1.6) 9,070 4.9 (4.4-5.3)
59 46,937 1.4 (1.3-1.5) 36,718 1.4 (1.3-1.6) 4,323 0.6 (0.4-0.9) 7,315 1.7 (1.5-2.1)
Probable/possible carcinogen
26 29,645 0.3 (0.2-0.3) - - - - - -
30 14,868 0.3 (0.2-0.4) 12,564 0.3 (0.2-0.4) 1,103 0.1 (0.0-0.5) 1,262 0.1 (0.0-0.4)
34 21,904 0.1 (0.1-0.1) 17,035 0.1 (0.1-0.2) 1,992 0.1 (0.0-0.3) 3,012 0.1 (0.1-0.3)
53 34,132 0.5 (0.5-0.6) - - - - - -
66 40,335 0.4 (0.4-0.5) 31,216 0.4 (0.4-0.5) 3,861 0.2 (0.1-0.3) 6,051 0.6 (0.4-0.8)
67 22,826 0.3 (0.2-0.3) 18,236 0.3 (0.2-0.4) 1,806 0.1 (0.0-0.3) 3,238 0.2 (0.1-0.4)
68 40,411 0.8 (0.8-0.9) 30,946 0.8 (0.7-0.9) 3,845 0.3 (0.2-0.5) 5,753 0.8 (0.6-1.0)
69 20,431 0.2 (0.1-0.3) - - - - - -
70 33,216 0.2 (0.2-0.3) - - - - - -
73 29,094 0.5 (0.4-0.6) - - - - - -
82 30,357 0.2 (0.1-0.2) 22,888 0.2 (0.1-0.2) 2,327 0.0 (0.0-0.2) 4,919 0.3 (0.2-0.5)
97 781 0.1 (0.0-0.7) 781 0.1 (0.0-0.7) - - - -
NON-ONCOGENIC HPV TYPES
6 38,548 0.5 (0.4-0.6) - - - - - -
11 38,643 0.4 (0.4-0.5) - - - - - -
32 2,954 0.1 (0.0-0.2) - - - - - -
40 23,471 0.0 (0.0-0.0) - - - - - -
42 25,826 0.2 (0.2-0.3) 20,986 0.2 (0.1-0.2) 1,917 0.1 (0.0-0.3) 3,713 0.4 (0.2-0.6)
43 21,404 0.1 (0.0-0.1) - - - - - -
44 24,340 0.2 (0.2-0.3) 20,154 0.2 (0.1-0.3) 1,915 0.1 (0.0-0.4) 3,157 0.4 (0.2-0.7)
54 25,312 0.2 (0.2-0.3) - - - - - -
55 - - - - - - - -
57 6,821 0.0 (0.0-0.1) - - - - - -
61 23,743 0.3 (0.2-0.3) - - - - - -
62 7,093 0.4 (0.3-0.5) - - - - - -
64 - - - - - - - -
71 9,390 0.2 (0.1-0.3) - - - - - -
72 10,056 0.1 (0.1-0.2) - - - - - -
74 16,398 0.0 (0.0-0.1) - - - - - -
81 9,553 0.2 (0.1-0.3) - - - - - -
83 9,789 0.1 (0.1-0.2) - - - - - -
84 8,130 0.3 (0.2-0.5) - - - - - -
89 7,833 0.1 (0.1-0.3) - - - - - -
90 2,401 0.0 (0.0-0.2) - - - - - -
91 12,790 0.0 (0.0-0.1) - - - - - -
Data updated on 14 Dec 2016 (data as of 30 Jun 2015).
95% CI: 95% Confidence Interval;
Data sources: See references in Section 9.
4.1.3 Terminology
Adenocarcinoma
Invasive tumour with glandular and squamous elements intermingled.
A systematic review of the literature was conducted regarding the worldwide HPV-prevalence and type
distribution for anogenital carcinomas other than cervix from January 1986 to data as of indicated in
each section. The search terms for the review were HPV AND (anus OR anal) OR (penile) OR vagin*
OR vulv* using Pubmed. There were no limits in publication language. References cited in selected
articles were also investigated. Inclusion criteria were: HPV DNA detection by means of PCR, a mini-
mum of 10 cases by lesion and a detailed description of HPV DNA detection and genotyping techniques
used. The number of cases tested and HPV positive extracted for each study were pooled to estimate the
prevalence of HPV DNA and the HPV type distribution globally and by geographical region. Binomial
95% confidence intervals were calculated for each HPV prevalence.
Anal cancer is similar to cervical cancer with respect to overall HPV DNA positivity, with approximately
88% of cases associated with HPV infection worldwide (de Martel C et al. Lancet Oncol 2012;13(6):607-
15). HPV16 is the most common type detected, representing 73% of all HPV-positive tumours. HPV18
is the second most common type detected and is found in approximately 5% of cases. HPV DNA is also
detected in the majority of precancerous anal lesions (AIN) (91.5% in AIN1 and 93.9% in AIN2/3) (De
Vuyst H et al. Int J Cancer 2009; 124: 1626-36). In this section, the HPV prevalence among anal cancer
cases in the World is presented.
Figure 85: Comparison of the ten most frequent HPV types in anal cancer cases in Africa and the rest
of the World
16 28.6 16 71.4
18 9.5 18 4.2
6 9.5 33 3.0
31 4.8 6 2.4
35 4.8 31 2.0
45 4.8 35 1.6
51 4.8 58 1.6
8th* 11 1.4
9th* 39 1.2
10th* 52 1.2
0 10 20 30 40 50 60 70 80 0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
AIN 2/3: Anal intraepithelial neoplasia of grade 2/3;
a Includes cases from Mali, Nigeria and Senegal.
b Includes cases from Europe (Bosnia-Herzegovina, Czech Republic, France, Germany, Poland, Portugal, Slovenia, Spain and United Kingdom); America (Chile, Colombia, Ecuador,
Guatemala, Honduras, Mexico, Paraguay and United States); Africa (Mali, Nigeria and Senegal); Asia (Bangladesh,India and South Korea)
Data sources: See references in Section 9.
Figure 86: Comparison of the ten most frequent HPV types in anal cancer cases in the Americas and
the rest of the World
16 74.3 16 71.4
18 4.3 18 4.2
33 4.3 33 3.0
31 2.8 6 2.4
58 2.8 31 2.0
39 2.4 35 1.6
52 2.0 58 1.6
6 1.6 11 1.4
45 1.2 39 1.2
11 0.8 52 1.2
0 10 20 30 40 50 60 70 80 0 10 20 30 40 50 60 70 80
Figure 87: Comparison of the ten most frequent HPV types in anal cancer cases in Asia and the rest of
the World
16 67.3 16 71.4
18 3.8 18 4.2
35 3.8 33 3.0
56 1.9 6 2.4
58 1.9 31 2.0
6 35 1.6
11 58 1.6
26 11 1.4
30 39 1.2
31 52 1.2
0 10 20 30 40 50 60 70 80 0 10 20 30 40 50 60 70 80
Figure 88: Comparison of the ten most frequent HPV types in anal cancer cases in Europe and the rest
of the World
16 73.4 16 71.4
6 3.6 18 4.2
18 3.6 33 3.0
11 3.0 6 2.4
33 2.4 31 2.0
35 1.8 35 1.6
74 1.8 58 1.6
31 1.2 11 1.4
30 0.6 39 1.2
52 0.6 52 1.2
0 10 20 30 40 50 60 70 80 0 10 20 30 40 50 60 70 80
Figure 89: Comparison of the ten most frequent HPV types in anal cancer cases in Oceania and the rest
of the World
1st* 16 71.4
2nd* 18 4.2
3rd* 33 3.0
4th* 6 2.4
5th* 31 2.0
No data available
6th* 35 1.6
7th* 58 1.6
8th* 11 1.4
9th* 39 1.2
10th* 52 1.2
0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
AIN 2/3: Anal intraepithelial neoplasia of grade 2/3;
a Includes cases from Europe (Bosnia-Herzegovina, Czech Republic, France, Germany, Poland, Portugal, Slovenia, Spain and United Kingdom); America (Chile, Colombia, Ecuador,
Guatemala, Honduras, Mexico, Paraguay and United States); Africa (Mali, Nigeria and Senegal); Asia (Bangladesh,India and South Korea)
Data sources: See references in Section 9.
Figure 90: Comparison of the ten most frequent HPV types in AIN 2/3 cases in Africa and the rest of
the World
1st* 16 72.1
2nd* 6 9.3
3rd* 11 7.0
4th* 18 4.7
5th* 31 4.7
No data available
6th* 51 4.7
7th* 74 4.7
8th* 35 2.3
9th* 44 2.3
10th* 45 2.3
0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
AIN 2/3: Anal intraepithelial neoplasia of grade 2/3;
a Includes cases from Europe (Bosnia-Herzegovina, Czech Republic, France, Germany, Poland, Portugal, Slovenia, Spain and United Kingdom); America (Chile, Colombia, Ecuador,
Guatemala, Honduras, Mexico and Paraguay)
Data sources: See references in Section 9.
Figure 91: Comparison of the ten most frequent HPV types in AIN 2/3 cases in the Americas and the
rest of the World
16 91.7 16 72.1
11 8.3 6 9.3
6 8.3 11 7.0
4th* 18 4.7
5th* 31 4.7
6th* 51 4.7
7th* 74 4.7
8th* 35 2.3
9th* 44 2.3
10th* 45 2.3
0 10 30 50 70 90 0 10 30 50 70 90
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
AIN 2/3: Anal intraepithelial neoplasia of grade 2/3;
a Includes cases from Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico and Paraguay.
b Includes cases from Europe (Bosnia-Herzegovina, Czech Republic, France, Germany, Poland, Portugal, Slovenia, Spain and United Kingdom); America (Chile, Colombia, Ecuador,
Guatemala, Honduras, Mexico and Paraguay)
Data sources: See references in Section 9.
Figure 92: Comparison of the ten most frequent HPV types in AIN 2/3 cases in Asia and the rest of the
World
1st* 16 72.1
2nd* 6 9.3
3rd* 11 7.0
4th* 18 4.7
5th* 31 4.7
No data available
6th* 51 4.7
7th* 74 4.7
8th* 35 2.3
9th* 44 2.3
10th* 45 2.3
0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
AIN 2/3: Anal intraepithelial neoplasia of grade 2/3;
a Includes cases from Europe (Bosnia-Herzegovina, Czech Republic, France, Germany, Poland, Portugal, Slovenia, Spain and United Kingdom); America (Chile, Colombia, Ecuador,
Guatemala, Honduras, Mexico and Paraguay)
Data sources: See references in Section 9.
Figure 93: Comparison of the ten most frequent HPV types in AIN 2/3 cases in Europe and the rest of
the World
16 65.2 16 72.1
18 8.7 6 9.3
51 8.7 11 7.0
6 8.7 18 4.7
74 8.7 31 4.7
11 4.3 51 4.7
31 4.3 74 4.7
35 4.3 35 2.3
44 4.3 44 2.3
45 4.3 45 2.3
0 10 20 30 40 50 60 70 80 0 10 20 30 40 50 60 70 80
Figure 94: Comparison of the ten most frequent HPV types in AIN 2/3 cases in Oceania and the rest of
the World
1st* 16 72.1
2nd* 6 9.3
3rd* 11 7.0
4th* 18 4.7
5th* 31 4.7
No data available
6th* 51 4.7
7th* 74 4.7
8th* 35 2.3
9th* 44 2.3
10th* 45 2.3
0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
AIN 2/3: Anal intraepithelial neoplasia of grade 2/3;
a Includes cases from Europe (Bosnia-Herzegovina, Czech Republic, France, Germany, Poland, Portugal, Slovenia, Spain and United Kingdom); America (Chile, Colombia, Ecuador,
Guatemala, Honduras, Mexico and Paraguay)
Data sources: See references in Section 9.
HPV attribution for vulvar cancer is 43% worldwide (de Martel C et al. Lancet Oncol 2012;13(6):607-
15). Vulvar cancer has two distinct histological patterns with two different risk factor profiles: (1) basa-
loid/warty types (2) keratinising types. Basaloid/warty lesions are more common in young women, are
frequently found adjacent to VIN, are very often associated with HPV DNA detection (86%), and have
a similar risk factor profile as cervical cancer. Keratinising vulvar carcinomas represent the majority
of the vulvar lesions (>60%). These lesions develop from non HPV-related chronic vulvar dermatoses,
especially lichen sclerosus and/or squamous hyperplasia, their immediate cancer precursor lesion is dif-
ferentiated VIN, they occur more often in older women, and are rarely associated with HPV (6%) or with
any of the other risk factors typical of cervical cancer. HPV prevalence is frequently detected among
cases of high-grade VIN (VIN2/3) (85.3%). HPV 16 is the most common type detected followed by HPV
33 (De Vuyst H et al. Int J Cancer 2009; 124:1626-36). In this section, the HPV prevalence among
vulvar cancer cases in the World is presented.
Figure 95: Comparison of the ten most frequent HPV types in vulvar cancer cases in Africa and the rest
of the World
16 58.3 16 19.4
18 4.2 33 1.8
45 4.2 18 1.5
52 4.2 45 0.9
5th* 6 0.6
6th* 31 0.6
7th* 44 0.6
8th* 52 0.5
9th* 51 0.4
10th* 56 0.4
0 10 20 30 40 50 60 0 10 20 30 40 50 60
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
VIN 2/3: Vulvar intraepithelial neoplasia of grade 2/3;
a Includes cases from Mali, Mozambique, Nigeria, and Senegal.
b Includes cases from America (Argentina, Brazil, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Uruguay, United States of America and Venezuela); Africa (Mali,
Mozambique, Nigeria, and Senegal); Oceania (Australia and New Zealand); Europe (Austria, Belarus, Bosnia-Herzegovina, Czech Republic, France, Germany, Greece, Italy, Poland, Portugal,
Spain and United Kingdom); and in Asia (Bangladesh, India, Israel, South Korea, Kuwait, Lebanon, Philippines, Taiwan and Turkey)
Data sources: See references in Section 9.
Figure 96: Comparison of the ten most frequent HPV types in vulvar cancer cases in the Americas and
the rest of the World
16 26.5 16 19.4
33 2.9 33 1.8
18 2.7 18 1.5
45 2.1 45 0.9
6 1.3 6 0.6
52 0.8 31 0.6
56 0.8 44 0.6
31 0.5 52 0.5
39 0.5 51 0.4
51 0.5 56 0.4
0 10 20 30 0 10 20 30
Figure 97: Comparison of the ten most frequent HPV types in vulvar cancer cases in Asia and the rest
of the World
16 18.1 16 19.4
18 1.6 33 1.8
44 1.6 18 1.5
45 1.1 45 0.9
52 1.1 6 0.6
58 1.1 31 0.6
11 0.5 44 0.6
26 0.5 52 0.5
30 0.5 51 0.4
31 0.5 56 0.4
0 10 20 0 10 20
Figure 98: Comparison of the ten most frequent HPV types in vulvar cancer cases in Europe and the
rest of the World
16 13.8 16 19.4
33 1.2 33 1.8
18 0.6 18 1.5
31 0.6 45 0.9
44 0.4 6 0.6
51 0.4 31 0.6
53 0.3 44 0.6
58 0.3 52 0.5
74 0.3 51 0.4
35 0.2 56 0.4
0 10 20 0 10 20
Figure 99: Comparison of the ten most frequent HPV types in vulvar cancer cases in Oceania and the
rest of the World
16 27.3 16 19.4
33 3.6 33 1.8
18 2.7 18 1.5
39 1.4 45 0.9
6 1.4 6 0.6
31 0.9 31 0.6
44 0.9 44 0.6
45 0.9 52 0.5
52 0.9 51 0.4
56 0.9 56 0.4
0 10 20 30 0 10 20 30
Figure 100: Comparison of the ten most frequent HPV types in VIN 2/3 cases in Africa and the rest of
the World
1st* 16 67.1
2nd* 33 10.2
3rd* 6 2.4
4th* 18 2.4
5th* 31 1.9
No data available
6th* 52 1.4
7th* 51 1.2
8th* 56 0.9
9th* 74 0.9
10th* 66 0.7
0 10 20 30 40 50 60 70
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
VIN 2/3: Vulvar intraepithelial neoplasia of grade 2/3;
a Includes cases from America (Argentina, Brazil, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Uruguay and Venezuela); Oceania (Australia and New Zealand);
Europe (Austria, Belarus, Bosnia-Herzegovina, Czech Republic, France, Germany, Greece, Italy, Poland, Portugal, Spain and United Kingdom); and in Asia (Bangladesh, India, Israel, South
Korea, Kuwait, Lebanon, Philippines, Taiwan and Turkey)
Data sources: See references in Section 9.
Figure 101: Comparison of the ten most frequent HPV types in VIN 2/3 cases in the Americas and the
rest of the World
16 56.7 16 67.1
33 8.7 33 10.2
6 4.7 6 2.4
31 3.9 18 2.4
11 1.6 31 1.9
45 1.6 52 1.4
51 1.6 51 1.2
52 1.6 56 0.9
58 1.6 74 0.9
18 0.8 66 0.7
0 10 20 30 40 50 60 70 0 10 20 30 40 50 60 70
Figure 102: Comparison of the ten most frequent HPV types in VIN 2/3 cases in Asia and the rest of the
World
16 80.0 16 67.1
6 5.0 33 10.2
18 5.0 6 2.4
33 5.0 18 2.4
35 5.0 31 1.9
54 5.0 52 1.4
7th* 51 1.2
8th* 56 0.9
9th* 74 0.9
10th* 66 0.7
0 10 20 30 40 50 60 70 80 90 0 10 20 30 40 50 60 70 80 90
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
VIN 2/3: Vulvar intraepithelial neoplasia of grade 2/3;
a Includes cases from Bangladesh, India, Israel, South Korea, Kuwait, Lebanon, Philippines, Taiwan and Turkey.
b Includes cases from America (Argentina, Brazil, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Uruguay and Venezuela); Oceania (Australia and New Zealand);
Europe (Austria, Belarus, Bosnia-Herzegovina, Czech Republic, France, Germany, Greece, Italy, Poland, Portugal, Spain and United Kingdom); and in Asia (Bangladesh, India, Israel, South
Korea, Kuwait, Lebanon, Philippines, Taiwan and Turkey)
Data sources: See references in Section 9.
Figure 103: Comparison of the ten most frequent HPV types in VIN 2/3 cases in Europe and the rest of
the World
16 69.6 16 67.1
33 11.2 33 10.2
18 2.2 6 2.4
6 1.6 18 2.4
52 1.3 31 1.9
56 1.3 52 1.4
44 1.0 51 1.2
66 1.0 56 0.9
74 1.0 74 0.9
31 0.6 66 0.7
0 10 20 30 40 50 60 70 0 10 20 30 40 50 60 70
Figure 104: Comparison of the ten most frequent HPV types in VIN 2/3 cases in Oceania and the rest
of the World
16 71.2 16 67.1
33 10.4 33 10.2
18 4.0 6 2.4
31 3.2 18 2.4
6 1.6 31 1.9
51 1.6 52 1.4
11 0.8 51 1.2
34 0.8 56 0.9
40 0.8 74 0.9
42 0.8 66 0.7
0 10 20 30 40 50 60 70 80 0 10 20 30 40 50 60 70 80
Vaginal and cervical cancers share similar risk factors and it is generally accepted that both carcinomas
share the same aetiology of HPV infection although there is limited evidence available. Women with
vaginal cancer are more likely to have a history of other anogenital cancers, particularly of the cervix,
and these two carcinomas are frequently diagnosed simultaneously. HPV DNA is detected among 70%
of invasive vaginal carcinomas and 91% of high-grade vaginal neoplasias (VaIN2/3). HPV16 is the
most common type in high-grade vaginal neoplasias and it is detected in at least 70% of HPV-positive
carcinomas (de Martel C et al. Lancet Oncol 2012;13(6):607-15; De Vuyst H et al. Int J Cancer 2009;
124: 1626-36).
Figure 105: Comparison of the ten most frequent HPV types in vaginal cancer cases in Africa and the
rest of the World
16 31.6 16 43.6
45 10.5 31 3.9
18 5.3 18 3.7
31 5.3 33 3.7
33 5.3 45 2.7
39 5.3 58 2.7
7th* 52 2.2
8th* 51 1.7
9th* 73 1.7
10th* 39 1.5
0 10 20 30 40 50 0 10 20 30 40 50
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
VAIN 2/3: Vaginal intraepithelial neoplasia of grade 2/3;
a Includes cases from Mozambique, Nigeria.
b Includes cases from Europe (Austria, Belarus, Czech Republic, France, Germany, Greece, Poland, Spain and United Kingdom); America (Argentina, Brazil, Chile, Colombia, Ecuador,
Guatemala, Mexico, Paraguay, Uruguay, United states of America and Venezuela); Africa (Mozambique, Nigeria); Asia (Bangladesh, India, Israel, South Korea, Kuwait, Philippines, Taiwan
and Turkey); and Oceania (Australia)
Data sources: See references in Section 9.
Figure 106: Comparison of the ten most frequent HPV types in vaginal cancer cases in the Americas
and the rest of the World
16 42.4 16 43.6
31 5.8 31 3.9
18 4.2 18 3.7
33 4.2 33 3.7
52 3.1 45 2.7
58 3.1 58 2.7
45 2.6 52 2.2
51 2.6 51 1.7
39 2.1 73 1.7
59 1.6 39 1.5
0 10 20 30 40 50 0 10 20 30 40 50
Figure 107: Comparison of the ten most frequent HPV types in vaginal cancer cases in Asia and the
rest of the World
16 39.4 16 43.6
33 3.0 31 3.9
68 3.0 18 3.7
18 3.0 33 3.7
26 3.0 45 2.7
45 3.0 58 2.7
51 3.0 52 2.2
52 3.0 51 1.7
56 3.0 73 1.7
59 3.0 39 1.5
0 10 20 30 40 50 0 10 20 30 40 50
Figure 108: Comparison of the ten most frequent HPV types in vaginal cancer cases in Europe and the
rest of the World
16 47.4 16 43.6
18 3.3 31 3.9
73 3.3 18 3.7
33 2.6 33 3.7
56 2.6 45 2.7
58 2.6 58 2.7
31 2.0 52 2.2
35 1.3 51 1.7
45 1.3 73 1.7
52 1.3 39 1.5
0 10 20 30 40 50 0 10 20 30 40 50
Figure 109: Comparison of the ten most frequent HPV types in vaginal cancer cases in Oceania and the
rest of the World
16 46.2 16 43.6
33 7.7 31 3.9
68 7.7 18 3.7
31 7.7 33 3.7
58 7.7 45 2.7
6th* 58 2.7
7th* 52 2.2
8th* 51 1.7
9th* 73 1.7
10th* 39 1.5
0 10 20 30 40 50 0 10 20 30 40 50
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
VAIN 2/3: Vaginal intraepithelial neoplasia of grade 2/3;
a Includes cases from Australia
b Includes cases from Europe (Austria, Belarus, Czech Republic, France, Germany, Greece, Poland, Spain and United Kingdom); America (Argentina, Brazil, Chile, Colombia, Ecuador,
Guatemala, Mexico, Paraguay, Uruguay, United states of America and Venezuela); Africa (Mozambique, Nigeria); Asia (Bangladesh, India, Israel, South Korea, Kuwait, Philippines, Taiwan
and Turkey); and Oceania (Australia)
Data sources: See references in Section 9.
Figure 110: Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Africa and the rest of
the World
1st* 16 56.1
2nd* 18 5.3
3rd* 52 5.3
4th* 73 4.8
5th* 33 4.2
No data available
6th* 59 3.7
7th* 56 2.6
8th* 51 2.1
9th* 6 1.6
10th* 35 1.6
0 10 20 30 40 50 60
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
a Includes cases from Europe (Austria, Belarus, Czech Republic, France, Germany, Greece, Poland, Spain and United Kingdom); America (Argentina, Brazil, Chile, Colombia, Ecuador,
Guatemala, Mexico, Paraguay, Uruguay, United states of America and Venezuela); Asia (Bangladesh, India, Israel, South Korea, Kuwait, Philippines, Taiwan and Turkey); and Oceania
(Australia)
Data sources: See references in Section 9.
Figure 111: Comparison of the ten most frequent HPV types in VaIN 2/3 cases in the Americas and the
rest of the World
16 46.3 16 56.1
18 6.3 18 5.3
52 6.3 52 5.3
73 6.3 73 4.8
51 3.8 33 4.2
56 3.8 59 3.7
6 3.8 56 2.6
31 2.5 51 2.1
58 2.5 6 1.6
59 2.5 35 1.6
0 10 20 30 40 50 60 0 10 20 30 40 50 60
Figure 112: Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Asia and the rest of
the World
16 53.8 16 56.1
52 15.4 18 5.3
59 15.4 52 5.3
45 7.7 73 4.8
73 7.7 33 4.2
6th* 59 3.7
7th* 56 2.6
8th* 51 2.1
9th* 6 1.6
10th* 35 1.6
0 10 20 30 40 50 60 0 10 20 30 40 50 60
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
a Includes cases from Australia, Bangladesh, India, Israel, South Korea, Kuwait, Philippines, Taiwan and Turkey.
b Includes cases from Europe (Austria, Belarus, Czech Republic, France, Germany, Greece, Poland, Spain and United Kingdom); America (Argentina, Brazil, Chile, Colombia, Ecuador,
Guatemala, Mexico, Paraguay, Uruguay, United states of America and Venezuela); Asia (Bangladesh, India, Israel, South Korea, Kuwait, Philippines, Taiwan and Turkey); and Oceania
(Australia)
Data sources: See references in Section 9.
Figure 113: Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Europe and the rest
of the World
16 65.6 16 56.1
33 7.3 18 5.3
18 5.2 52 5.3
52 3.1 73 4.8
73 3.1 33 4.2
35 2.1 59 3.7
53 2.1 56 2.6
56 2.1 51 2.1
59 2.1 6 1.6
30 1.0 35 1.6
0 10 20 30 40 50 60 70 0 10 20 30 40 50 60 70
Figure 114: Comparison of the ten most frequent HPV types in VaIN 2/3 cases in Oceania and the rest
of the World
16 53.8 16 56.1
52 15.4 18 5.3
59 15.4 52 5.3
45 7.7 73 4.8
73 7.7 33 4.2
6th* 59 3.7
7th* 56 2.6
8th* 51 2.1
9th* 6 1.6
10th* 35 1.6
0 10 20 30 40 50 60 0 10 20 30 40 50 60
*No data available. No more types than shown were tested or were positive.
Data updated on 20 Mar 2015 (data as of 30 Jun 2014).
a Includes cases from Australia, Bangladesh, India, Israel, South Korea, Kuwait, Philippines, Taiwan and Turkey.
b Includes cases from Europe (Austria, Belarus, Czech Republic, France, Germany, Greece, Poland, Spain and United Kingdom); America (Argentina, Brazil, Chile, Colombia, Ecuador,
Guatemala, Mexico, Paraguay, Uruguay, United states of America and Venezuela); Asia (Bangladesh, India, Israel, South Korea, Kuwait, Philippines, Taiwan and Turkey); and Oceania
(Australia)
Data sources: See references in Section 9.
HPV DNA is detectable in approximately 50% of all penile cancers (de Martel C et al. Lancet Oncol
2012;13(6):607-15). Among HPV-related penile tumours, HPV16 is the most common type detected,
followed by HPV18 and HPV types 6/11 (Miralles C et al. J Clin Pathol 2009;62:870-8). Over 95% of
invasive penile cancers are SCC and the most common penile SCC histologic sub-types are keratinising
(49%), mixed warty-basaloid (17%), verrucous (8%), warty (6%), and basaloid (4%). HPV is commonly
detected in basaloid and warty tumours but is less common in keratinising and verrucous tumours. In
this section, the HPV prevalence among penile cancer cases in the World is presented.
Figure 115: Comparison of the ten most frequent HPV types in penile cancer cases in Africa and the
rest of the World
16 26.3 16 22.8
30 5.3 6 1.6
33 5.3 33 1.2
52 5.3 35 1.0
5th* 45 1.0
6th* 52 0.9
7th* 11 0.7
8th* 18 0.7
9th* 59 0.7
10th* 74 0.6
0 10 20 30 0 10 20 30
*No data available. No more types than shown were tested or were positive.
Data updated on 14 Dec 2016 (data as of 30 Jun 2015).
a Includes cases from Mozambique, Nigeria, Senegal
b Includes cases from Australia, Bangladesh, India, South Korea, Lebanon, Philippines, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Venezuela and United States,
Mozambique, Nigeria, Senegal, Czech Republic, France, Greece, Poland, Portugal, Spain and United Kingdom.
Figure 116: Comparison of the ten most frequent HPV types in penile cancer cases in the Americas and
the rest of the World
16 23.8 16 22.8
6 2.5 6 1.6
11 1.5 33 1.2
33 1.3 35 1.0
35 1.3 45 1.0
45 1.3 52 0.9
59 1.3 11 0.7
18 1.0 18 0.7
51 0.6 59 0.7
52 0.6 74 0.6
0 10 20 30 0 10 20 30
Figure 117: Comparison of the ten most frequent HPV types in penile cancer cases in Asia and the rest
of the World
16 9.0 16 22.8
33 1.5 6 1.6
35 1.5 33 1.2
45 1.5 35 1.0
5th* 45 1.0
6th* 52 0.9
7th* 11 0.7
8th* 18 0.7
9th* 59 0.7
10th* 74 0.6
0 10 20 30 0 10 20 30
*No data available. No more types than shown were tested or were positive.
Data updated on 14 Dec 2016 (data as of 30 Jun 2015).
a Includes cases from Bangladesh, India, South Korea, Lebanon, Philippinesy
b Includes cases from Australia, Bangladesh, India, South Korea, Lebanon, Philippines, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Venezuela and United States,
Mozambique, Nigeria, Senegal, Czech Republic, France, Greece, Poland, Portugal, Spain and United Kingdom.
Figure 118: Comparison of the ten most frequent HPV types in penile cancer cases in Europe and the
rest of the World
16 23.4 16 22.8
52 1.2 6 1.6
6 1.0 33 1.2
33 1.0 35 1.0
45 0.7 45 1.0
58 0.7 52 0.9
18 0.5 11 0.7
31 0.5 18 0.7
35 0.5 59 0.7
44 0.5 74 0.6
0 10 20 30 0 10 20 30
Figure 119: Comparison of the ten most frequent HPV types in penile cancer cases in Oceania and the
rest of the World
1st* 16 22.8
2nd* 6 1.6
3rd* 33 1.2
4th* 35 1.0
5th* 45 1.0
No data available
6th* 52 0.9
7th* 11 0.7
8th* 18 0.7
9th* 59 0.7
10th* 74 0.6
0 10 20 30
*No data available. No more types than shown were tested or were positive.
Data updated on 14 Dec 2016 (data as of 30 Jun 2015).
a Includes cases from Australia, Bangladesh, India, South Korea, Lebanon, Philippines, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Venezuela and United States,
Mozambique, Nigeria, Senegal, Czech Republic, France, Greece, Poland, Portugal, Spain and United Kingdom.
Figure 120: Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Africa and the rest of
the World
1st* 16 69.4
2nd* 33 5.9
3rd* 58 4.7
4th* 31 3.5
5th* 51 3.5
No data available
6th* 52 3.5
7th* 6 2.4
8th* 18 2.4
9th* 45 2.4
10th* 53 2.4
0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 14 Dec 2016 (data as of 30 Jun 2015).
a Includes cases from Australia, Bangladesh, India, South Korea, Lebanon, Philippines, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Venezuela, Mozambique,
Nigeria, Senegal, Czech Republic, France, Greece, Poland, Portugal, Spain and United Kingdom.
Figure 121: Comparison of the ten most frequent HPV types in PeIN 2/3 cases in the Americas and the
rest of the World
16 36.4 16 69.4
66 18.2 33 5.9
11 9.1 58 4.7
31 9.1 31 3.5
51 9.1 51 3.5
52 9.1 52 3.5
53 9.1 6 2.4
58 9.1 18 2.4
61 9.1 45 2.4
6 53 2.4
0 10 20 30 40 50 60 70 80 0 10 20 30 40 50 60 70 80
Figure 122: Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Asia and the rest of
the World
1st* 16 69.4
2nd* 33 5.9
3rd* 58 4.7
4th* 31 3.5
5th* 51 3.5
No data available
6th* 52 3.5
7th* 6 2.4
8th* 18 2.4
9th* 45 2.4
10th* 53 2.4
0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 14 Dec 2016 (data as of 30 Jun 2015).
a Includes cases from Australia, Bangladesh, India, South Korea, Lebanon, Philippines, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Venezuela, Mozambique,
Nigeria, Senegal, Czech Republic, France, Greece, Poland, Portugal, Spain and United Kingdom.
Figure 123: Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Europe and the rest
of the World
16 73.4 16 69.4
33 6.3 33 5.9
6 3.1 58 4.7
18 3.1 31 3.5
31 3.1 51 3.5
45 3.1 52 3.5
51 3.1 6 2.4
52 3.1 18 2.4
58 3.1 45 2.4
43 1.6 53 2.4
0 10 20 30 40 50 60 70 80 90 0 10 20 30 40 50 60 70 80 90
Figure 124: Comparison of the ten most frequent HPV types in PeIN 2/3 cases in Oceania and the rest
of the World
1st* 16 69.4
2nd* 33 5.9
3rd* 58 4.7
4th* 31 3.5
5th* 51 3.5
No data available
6th* 52 3.5
7th* 6 2.4
8th* 18 2.4
9th* 45 2.4
10th* 53 2.4
0 10 20 30 40 50 60 70 80
*No data available. No more types than shown were tested or were positive.
Data updated on 14 Dec 2016 (data as of 30 Jun 2015).
a Includes cases from Australia, Bangladesh, India, South Korea, Lebanon, Philippines, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Venezuela, Mozambique,
Nigeria, Senegal, Czech Republic, France, Greece, Poland, Portugal, Spain and United Kingdom.
HPV burden in men was based on published systematic reviews and meta-analyses (Dunne EF, J Infect
Dis 2006; 194: 1044, Smith JS, J Adolesc Health 2011; 48: 540, and Hebnes JB, J Sex Med 2014; 11:
2630) up to September 15, 2014. The search terms for the review were human papillomavirus, men,
polymerase chain reaction (PCR), hybrid capture (HC), and viral DNA. References cited in selected ar-
ticles were also investigated. Inclusion criteria were: HPV DNA detection by means of PCR or HC, a
minimum of 20 cases for men and a detailed description of HPV DNA detection and genotyping tech-
niques used. The number of cases tested and HPV positive extracted for each study were pooled to
estimate the prevalence of HPV DNA globally and by geographical region. Binomial 95% confidence
intervals were calculated for each HPV prevalence.
Table 25: Studies on anogenital HPV prevalence among men from special subgroups
Anatomic sites HPV detection Age HPV prev
Country Study samples method Population (years) No % (95% CI)
Australia Anderson Anal canal HC2 HR HIV+ MSM Median 45 123 86.2 (78.8-91.7)
2008 (28-59)
Goldstone Anus RT-PCR-Multiplex HIV- MSM Median 22 602 42.4 (38.4-46.4)
2011 or Biplex (16-27)
Penis RT-PCR-Multiplex HIV- MSM Median 22 602 18.4 (15.4-21.8)
or Biplex (16-27)
Vajdic 2009 Anal canal HC2 HIV- MSM IQR=36- 193 69.9 (62.9-76.3)
48
HIV+ MSM IQR=37- 123 94.3 (88.6-97.7)
49
Vardas 2011 Penis RT-PCR-Multiplex Heterosexual men Median 20 3132 21.2 (19.8-22.7)
or Biplex (15-24)
Brazil de Lima Coronal sulcus, PCR-GP5+/6+ Sexual partners of 18-60 43 51.2 (35.5-66.7)
Rocha 2012 glans, and women with cervical
prepuce HPV infection
Franceschi Glans, corona, PCR-GP5+/6+ Husbands of women 27-79 53 35.8 (23.1-50.2)
2002 urethra with invasive cervical
cancer
Freire 2014 Shaft, glans, PCR-Papillocheck Men referred to the 18-81 355 72.1 (67.1-76.7)
balanopreputial Urological Division
sulcus and
urethral
HPV detection
Method and
targeted HPV Age No. HPV prevalence
Country Study types Population (years) Tested % (95% CI)
United Kingdom Kujan 2006 PCR-Roche master mix Healthy volunteers from - 24 12.5 (2.7-32.4)
and HC2 digene (both university dental
able to detect the hospital.
following HR types: 16,
18, 31, 33, 35, 39, 45, 51,
52, 56, 58, 59 and 68). No
further genotyping
BOTH OR UNSPECIFIED
Denmark Eike 1995 PCR-MY09/11. Patients with unrelated 20-79 61 0.0 (0.0-5.9)
Genotyping by disease (otosclerosis,
amplification with TS nasal complaints)and
primers (6, 11, 16, 18) their accompanying
and RFLP relatives
Finland Leimola-Virtanen 1996 PCR-GP5/GP6. No Post-menopausal women 55 131 10.7 (6.0-17.3)
genotyping participating in annual
mass-screening program
for the detection of
cervical precancerous
lesions
Finland Kero 2011 PCR-GP5+/GP6+ and Spouses in 3rd - 128 17.2 (11.1-24.9)
MY09/MY11. Genotyping trimestres of pregnancy
with Multimerix kit (6, of the fathers-to-be of
11, 16, 18, 31, 33, 39, 42, cohort study
43, 44, 45, 51, 52, 58, 59,
68, 70, 73, 82)
Finland Kero 2012 PCR-GP5+/GP6+ and Fathers-to-be of cohort - 131 18.3 (12.1-26.0)
MY09/MY11. Genotyping study
with Multimerix kit (6,
11, 16, 18, 31, 33, 39, 42,
43, 44, 45, 51, 52, 58, 59,
68, 70, 73, 82)
Greece Lambropoulos 1997 PCR-MY09/MY11. Healthy population 14-85 169 9.5 (5.5-14.9)
Genotyping by SBH with receiving routine oral
TS probes (6, 11, 16, 18, examination
33)
Italy Montaldo 2007 PCR-MY09/MY11 and Dental clinic visitors 4-77 164 18.3 (12.7-25.1)
GP5+N. Genotyping by
sequencing
Italy Migaldi 2012 PCR-GP5+/GP6+, Patients undergoing to 49-77 81 1.2 (0.0-6.7)
MY09/11, LCRS/E7AS, routine oral examination
pU-1M and pU-2R.
Genotyping by
sequencing
Spain Caadas 2004 PCR-MY09/MY11. Female sex workers who - 188 8.5 (4.9-13.5)
Genotyping by DBH with attended a dermatology
TS probes (6, 11, 16, 18, or STD clinic.
26, 31-33, 35, 39, 40, 45,
51-56, 58, 59, 61, 66-68,
70, 71 (AE8), 72, 73, 81
(AE7), 83 (PAP291), 84
(PAP155), 85 (AE5), AE2
(IS39), and AE6)
United Kingdom Kujan 2006 PCR-Roche master mix Healthy volunteers from - 50 8.0 (2.2-19.2)
and HC2 digene (both university dental
able to detect the hospital.
following HR types: 16,
18, 31, 33, 35, 39, 45, 51,
52, 56, 58, 59 and 68). No
further genotyping
Data updated on 14 Dec 2016 (data as of 29 Feb 2012). Only for European countries.
95% CI: 95% Confidence Interval;
Data sources: See references in Section 9.
Table 27: Studies on HPV prevalence among cases of oral cavity cancer
HPV detection Prevalence of 5 most
method and targeted HPV prevalence frequent HPVs
Study HPV types No. Tested % (95% CI) HPV type (%)
MEN
Oliveira 2009 GP5+/GP6+ (L1) DBH (6. 11. 16. 57 31.6 (21.0-44.5) -
(Brazil) 18. 31. 33. 34. 35. 39. 40. 42. 43.
44. 45. 51. 52. 54. 56. 58)
Herrero 2003 GP5+/GP6+ (L1) Hybridization 17 11.8 (3.3-34.3) HPV 16 (11.8%)
(Canada) with EIA oligonucleotide probes
(2. 6. 11. 16. 18. 31. 33. 35. 39.
40. 42. 43. 44. 45. 51. 52. 56. 58.
59. 66. 68)
Noble-Topham TS-PCR E6/E7 for 6b/11/16/18 7 57.1 (25.0-84.2) HPV 18 (57.1%)
1993 (Canada) Amplification with TS primers HPV 16 (14.3%)
(6b/11. 16. 18)
Zhang 2004 TS-PCR E6 for 16/18 48 81.3 (68.1-89.8) -
(China) Amplification with TS primers
(16. 18)
Herrero 2003 GP5+/GP6+ (L1) Hybridization 53 0.0 (0.0-6.8) -
(Cuba) with EIA oligonucleotide probes
(2. 6. 11. 16. 18. 31. 33. 35. 39.
40. 42. 43. 44. 45. 51. 52. 56. 58.
59. 66. 68)
Nemes 2006 MY09/MY11 (L1) Hybridization 67 44.8 (33.5-56.6) -
(Hungary) with TS probes (16. 18. 31. 33.
45. 51. 52. 58)
Balaram 1995 (In- MY09/MY11 (L1). GP5+/GP6+ 50 74.0 (60.4-84.1) -
dia) (L1)/GP17+/GP18+ (L1). Y1/Y2
and TS-PCR for 6/11/16/18
Sequencing
Chaudhary 2010 MY09/MY11 (L1) Amplification 146 33.6 (26.4-41.6) HPV 16 (33.6%)
(India) with TS primers (16)
DCosta 1998 (In- MY09/MY11 (L1) SBH (6. 11. 71 12.7 (6.8-22.4) HPV 16 (12.7%)
dia) 16. 18. 33)
Herrero 2003 (In- GP5+/GP6+ (L1) Hybridization 127 4.7 (2.2-9.9) HPV 16 (3.9%)
dia) with EIA oligonucleotide probes HPV 18 (0.8%)
(2. 6. 11. 16. 18. 31. 33. 35. 39. HPV 35 (0.8%)
40. 42. 43. 44. 45. 51. 52. 56. 58.
59. 66. 68)
Saghravanian GP5+/GP6+ (L1) Amplification 8 0.0 (0.0-32.4) -
2011 (Iran) with TS primers HPV E6/7 (16.
18. 31. 33)
Herrero 2003 (Ire- GP5+/GP6+ (L1) Hybridization 22 4.5 (0.8-21.8) HPV 16 (4.5%)
land) with EIA oligonucleotide probes
(2. 6. 11. 16. 18. 31. 33. 35. 39.
40. 42. 43. 44. 45. 51. 52. 56. 58.
59. 66. 68)
Herrero 2003 GP5+/GP6+ (L1) Hybridization 32 0.0 (0.0-10.7) -
(Italy) with EIA oligonucleotide probes
(2. 6. 11. 16. 18. 31. 33. 35. 39.
40. 42. 43. 44. 45. 51. 52. 56. 58.
59. 66. 68)
Bhawal 2008 TS-PCR E6 for 16 19 26.3 (11.8-48.8) HPV 16 (26.3%)
(Japan) Electrophoretic analysis using
SiHa DNA as positive control for
HPV-16
MEN
Li 2007 (China) GP5+/GP6+ (L1). 21 14.3 (5.0-34.6) HPV 16 (14.3%)
CP65/70ct-CP66/69ct (L1).
FAP59/6415 (L1). A5/A10-A6/A8
(L1) and TS-PCR E6 for 16
Sequencing
Li 2007 (China) GP5+/GP6+ (L1). 21 14.3 (5.0-34.6) -
(China) CP65/70ct-CP66/69ct (L1).
FAP59/6415 (L1). A5/A10-A6/A8
(L1) and TS-PCR E6 for 16
Sequencing
Herrero 2003 GP5+/GP6+ (L1) Hybridization 21 19.0 (7.7-40.0) HPV 16 (19.0%)
(Cuba) with EIA oligonucleotide probes
(2. 6. 11. 16. 18. 31. 33. 35. 39.
40. 42. 43. 44. 45. 51. 52. 56. 58.
59. 66. 68)
Herrero 2003 GP5+/GP6+ (L1) Hybridization 21 19.0 (7.7-40.0) -
(Cuba) (Cuba) with EIA oligonucleotide probes
(2. 6. 11. 16. 18. 31. 33. 35. 39.
40. 42. 43. 44. 45. 51. 52. 56. 58.
59. 66. 68)
Table 29: Studies on HPV prevalence among cases of hypopharyngeal or laryngeal cancer
HPV detection Prevalence of 5 most
method and targeted HPV prevalence frequent HPVs
Study HPV types No. Tested % (95% CI) HPV type (%)
MEN
Fliss 1994 TS-PCR E6/E7 for 6b/11/16/18 28 46.4 (29.5-64.2) HPV 16 (32.1%)
(Canada) Amplification with TS primers HPV 18 (32.1%)
(6b/11. 16. 18)
Self-reported quality assurance: Organised programs provide for a national or regional team responsible for implementation and require providers to follow guidelines, rules, or standard
operating procedures. They also define a quality assurance structure and mandate supervision and monitoring of the screening process. To evaluate impact, organised programs also require
ascertainment of the population disease burden. Quality assurance consists of the management and coordination of the program throughout all levels of the screening process (invitation,
testing, diagnosis and follow-up of screen-positives) to assure that the program performs adequately and provides services that are effective and in-line with program standards. The quality
assurance structure is self-reported as part of the national cancer programs or plans. For some countries when less than 50% of its regions havent had a quality assurance plan, the country
is categorised as not having quality assurance.
Note: For more detail information, please read the country report.
9 References
HPV-related statistics were gathered from specific databases created at the Institut Catal dOncologia and the International Agency for
Research on Cancer.
Systematic collection of published literature from peer-reviewed journals is stored in these databases. Data correspond to results from
the following reference papers as well as updated results from continuous monitoring of the literature by the HPV Information Centre:
Table 32 Continued
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South Africa Allan B, J Clin Microbiol 2008; 46: 740 | Denny L, JAMA 2005; 294: 2173 |
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103: 313 | Wright TC, JAMA 2000; 283: 81
Zimbabwe Baay MF, J Med Virol 2004; 73: 481 | Fukuchi E, Sex Transm Dis 2009; 36: 305
| Nowak RG, J Infect Dis 2011; 203: 1182 | Womack SD, Int J Cancer 2000; 85:
206
Americas
Argentina Abba MC, Rev Argent Microbiol 2003; 35: 74 | Badano I, Rev Argent Microbiol
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Belize Cathro HP, Hum Pathol 2009; 40: 942
Bolivia Cervantes J, Rev Inst Med Trop Sao Paulo 2003; 45: 131
Brazil Augusto EF, Rev Lat Am Enfermagem 2014; 22: 100 | Caixeta RC, Diagn
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Rocha DA, Infect Dis Obstet Gynecol 2013; 2013: 514859 | Roteli-Martins CM,
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Colombia Camargo M, BMC Cancer 2014; 14: 451 | Leon S, Sex Transm Dis 2009; 36: 290
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Costa Rica Herrero R, J Infect Dis 2005; 191: 1796 | Safaeian M, J Clin Microbiol 2007; 45:
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Cuba Soto Y, J Low Genit Tract Dis 2014; 18: 210
Ecuador Brown CR, Braz J Med Biol Res 2009; 42: 629
Guatemala Valls X, Int J Cancer 2009; 125: 1161
Guyana Kightlinger RS, Am J Obstet Gynecol 2010; 202: 626.e1
Honduras Ferrera A, Int J Cancer 1999; 82: 799 | Ferrera A, Int J Gynaecol Obstet 2011;
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(Continued)
Table 32 Continued
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Haiti Mandigo M, Int J Gynaecol Obstet 2015; 128: 206 | Walmer DK, PLoS ONE
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Jamaica Lewis-Bell K, Rev Panam Salud Publica 2013; 33: 159 | Watt A, Infect Agents
Cancer 2009; 4 Suppl 1: S11
Mexico Aguilar-Lemarroy A, J Med Virol 2015; 87: 871 | Carrillo-Garca A, Gynecol
Oncol 2014; 134: 534 | Giuliano AR, Cancer Epidemiol Biomarkers Prev 2001;
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Arch Med Res 1997; 28: 265 | Hernndez-Girn C, Sex Transm Dis 2005; 32:
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Gynecol Oncol 2010; 117: 291 | Lazcano-Ponce E, Cancer Causes Control 2010;
21: 1693 | Lazcano-Ponce E, Int J Cancer 2001; 91: 412 | Lpez Rivera MG,
Infect Dis Obstet Gynecol 2012; 2012: 384758 | Monroy OL, J Clin Virol 2010;
47: 43 | Orozco-Coln A, Int J Infect Dis 2010; 14: e1082 | Parada R, BMC Infect
Dis 2010; 10: 223 | Rojo Contreras W, Ginecol Obstet Mex 2008; 76: 9 | Salcedo
M, Asian Pac J Cancer Prev 2014; 15: 10061 | Salmern J, Cancer Causes
Control 2003; 14: 505 | Snchez-Anguiano LF, BMC Infect Dis 2006; 6: 27
Nicaragua Jeronimo J, Int J Gynecol Cancer 2014; 24: 576
Peru Almonte M, Int J Cancer 2007; 121: 796 | Garca PJ, Bull World Health Organ
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Asian Pac J Trop Med 2014; 7S1: S121
Paraguay Mendoza LP, J Med Virol 2011; 83: 1351 | Roln PA, Int J Cancer 2000; 85: 486
| Torres LM, Braz J Infect Dis 2009; 13: 203
Suriname Geraets DT, Sex Transm Infect 2014
Trinidad & Tobago Andall-Brereton GM, Rev Panam Salud Publica 2011; 29: 220 | Ragin CC,
Biomarkers 2007; 12: 510
Uruguay Berois N, J Med Virol 2014; 86: 647 | Ramas V, J Med Virol 2013; 85: 845
USA Castle PE, J Clin Oncol 2012; 30: 3044 | Castle PE, Lancet Oncol 2011; 12: 880
| Castle PE, Obstet Gynecol 2009; 113: 595 | Chaturvedi AK, J Med Virol 2005;
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JAMA 2007; 297: 813 | Evans MF, Cancer 2006; 106: 1054 | Giuliano AR,
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Epidemiol Biomarkers Prev 2001; 10: 1129 | Goodman MT, Cancer Res 2008; 68:
8813 | Hernandez BY, Nutr Cancer 2004; 49: 109 | Insinga RP, Cancer
Epidemiol Biomarkers Prev 2007; 16: 709 | Kahn JA, Obstet Gynecol 2008; 111:
1103 | Khanna N, Int J Gynecol Cancer 2007; 17: 615 | Kotloff KL, Sex Transm
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Tarkowski TA, J Infect Dis 2004; 189: 46 | Wheeler CM, Int J Cancer 2013; 132:
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Venezuela Michelli E, Invest Clin 2011; 52: 344 | Tellez L, Ecancermedicalscience 2015; 9:
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(Continued)
Table 32 Continued
Country Study
China Belinson J, Gynecol Oncol 2001; 83: 439 | Belinson JL, Am J Clin Pathol 2011;
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Ther Med 2013; 6: 1332 | Chan PK, J Infect Dis 2002; 185: 28 | Chan PK, J
Med Virol 2009; 81: 1635 | Chen Q, PLoS ONE 2012; 7: e32149 | Chen Z, Exp
Ther Med 2013; 6: 85 | Chui SH, Public Health 2012; 126: 600 | Dai M, Br J
Cancer 2006; 95: 96 | Ding X, J Med Virol 2014; 86: 1937 | DU H, Zhonghua Liu
Xing Bing Xue Za Zhi 2012; 33: 799 | He X, Eur J Epidemiol 2008; 23: 403 | Hu
SY, Chin J Cancer Res 2011; 23: 25 | Jin Q, Chin Med J 2010; 123: 2004 | Li C,
Cancer Epidemiol Biomarkers Prev 2010; 19: 2655 | Li H, Eur J Obstet Gynecol
Reprod Biol 2013; 170: 202 | Li LK, Br J Cancer 2006; 95: 1593 | Lin M, Aust N
Z J Obstet Gynaecol 2008; 48: 189 | Lu S, J Med Virol 2015; 87: 504 | Mai RQ,
Asian Pac J Cancer Prev 2014; 15: 4945 | Moy LM, Int J Cancer 2010; 127: 646
| Qiao YL, Lancet Oncol 2008; 9: 929 | Sui S, Asian Pac J Cancer Prev 2013; 14:
5861 | Sun LL, Virol J 2012; 9: 153 | Sun ZR, Int J Gynaecol Obstet 2010; 109:
105 | Wang S, BMC Cancer 2012; 12: 160 | Wang X, Int J Gynaecol Obstet 2013;
120: 37 | Wang XC, Asian Pac J Cancer Prev 2014; 15: 7333 | Wang YY, Asian
Pac J Cancer Prev 2013; 14: 7483 | Wei H, Int J Gynaecol Obstet 2014; 126: 28 |
Wu D, Eur J Obstet Gynecol Reprod Biol 2010; 151: 86 | Wu EQ, Cancer Causes
Control 2013; 24: 795 | Wu R, Int J Gynecol Cancer 2010; 20: 1411 | Wu RF, Int
J Cancer 2007; 121: 1306 | Ye J, Int J Gynecol Cancer 2010; 20: 1374 | Ye J,
Virol J 2010; 7: 66 | Yeoh GP, Acta Cytol 2006; 50: 627 | Yip YC, J Med Virol
2010; 82: 1724 | Yu XW, J Low Genit Tract Dis 2013; 17: 17 | Yuan X, Arch
Gynecol Obstet 2011; 283: 1385 | Zhang L, Arch Gynecol Obstet 2012; 286: 695
| Zhang R, J Clin Virol 2013; 58: 144 | Zhang WY, Chin Med J 2008; 121: 1578
| Zhao FH, Cancer Prev Res (Phila) 2013; 6: 938 | Zhao FH, Int J Cancer 2014;
135: 2604
Georgia Alibegashvili T, Cancer Epidemiol 2011; 35: 465
Indonesia de Boer MA, Int J Gynecol Cancer 2006; 16: 1809 | Rachmadi L, Acta Cytol
2012; 56: 171 | Vet JN, Br J Cancer 2008; 99: 214
India Aggarwal R, Indian J Cancer 2006; 43: 110 | Arora R, Eur J Obstet Gynecol
Reprod Biol 2005; 121: 104 | Basu P, Int J Cancer 2013; 132: 1693 | Bhatla N,
Int J Gynecol Pathol 2008; 27: 426 | Datta P, Cancer Epidemiol 2010; 34: 157 |
Dutta S, Int J Gynecol Pathol 2012; 31: 178 | Franceschi S, Br J Cancer 2005;
92: 601 | Gravitt PE, PLoS ONE 2010; 5: e13711 | Gupta S, Cytopathology
2009; 20: 249 | Jeronimo J, Int J Gynecol Cancer 2014; 24: 576 | Kashyap V, J
Cytol 2013; 30: 190 | Kerkar SC, Sex Reprod Healthc 2011; 2: 7 | Laikangbam
P, Int J Gynecol Cancer 2007; 17: 107 | Mittal S, Int J Gynaecol Obstet 2014;
126: 227 | Pandey S, Asian Pac J Cancer Prev 2012; 13: 2643 |
Sankaranarayanan R, Int J Cancer 2004; 112: 341 | Sankaranarayanan R, Int J
Cancer 2005; 116: 617 | Sarkar K, BMC Infect Dis 2011; 11: 72 | Singh A, Int J
Gynecol Cancer 2009; 19: 1642 | Srivastava S, J Biosci 2012; 37: 63 | Vinodhini
K, Int J Gynaecol Obstet 2012; 119: 253
Iran Eghbali SS, Virol J 2012; 9: 194 | Khodakarami N, Int J Cancer 2012; 131: E156
| Moradi A, Iran J Cancer Prev 2011; 3: 135 | Safaei A, Indian J Pathol
Microbiol 2010; 53: 681 | Shahramian I, Iran J Public Health 2011; 40: 113 |
Zandi K, Virol J 2010; 7: 65 | Zavarei 2008: reported in Vaccarella S, Vaccine
2013; 31 Suppl 6: G32
Japan Asato T, J Infect Dis 2004; 189: 1829 | Chen L, J Med Virol 2013; 85: 1229 |
Inoue M, Int J Gynecol Cancer 2006; 16: 1007 | Ishi K, J Obstet Gynaecol Res
2004; 30: 380 | Konno R, Cancer Sci 2011; 102: 877 | Maehama T, Infect Dis
Obstet Gynecol 2005; 13: 77 | Masumoto N, Gynecol Oncol 2004; 94: 509 |
Nishiwaki M, J Clin Microbiol 2008; 46: 1161 | Onuki M, Cancer Sci 2009; 100:
1312 | Saito J, Int J Gynaecol Obstet 1995; 51: 43 | Sasagawa T, Cancer
Epidemiol Biomarkers Prev 2001; 10: 45 | Sasagawa T, Jpn J Cancer Res 1997;
88: 376 | Sasagawa T, Sex Transm Infect 2005; 81: 280 | Satoh T, J Virol
Methods 2013; 188: 83 | Takehara K, Patholog Res Int 2011; 2011: 246936 |
Yoshikawa H, Br J Cancer 1999; 80: 621
(Continued)
Table 32 Continued
Country Study
Kazakhstan Buleshov 2011: reported in De Vuyst H, Vaccine 2013; 31 Suppl 5: F32
Republic of Korea An HJ, Cancer 2003; 97: 1672 | Bae J, Gynecol Oncol 2009; 115: 75 | Bae JH, J
Microbiol Biotechnol 2009; 19: 1051 | Bae JM, Arch Virol 2014; 159: 1909 | Cho
EJ, J Med Microbiol 2011; 60: 162 | Cho NH, Am J Obstet Gynecol 2003; 188: 56
| Hwang HS, Cancer Epidemiol Biomarkers Prev 2004; 13: 2153 | Hwang Y,
Ann Lab Med 2012; 32: 201 | Kim J, Int J Gynecol Cancer 2012; 22: 1570 | Kim
JH, Oncol Rep 2013; 29: 1645 | Kim JK, J Microbiol Biotechnol 2014; 24: 1143 |
Kim K, Asian Pac J Cancer Prev 2012; 13: 269 | Kim MA, J Korean Med Sci
2012; 27: 922 | Kim MA, Obstet Gynecol 2010; 116: 932 | Kim MJ, Obstet
Gynecol Sci 2013; 56: 110 | Kim TE, Korean J Pathol 2014; 48: 24 | Kim Y, J
Infect Chemother 2014; 20: 74 | Kim YJ, J Microbiol 2013; 51: 665 | Lee EH, J
Korean Med Sci 2012; 27: 1091 | Lee H, Epidemiol Infect 2014; 142: 1579 | Lee
HP, J Med Virol 2011; 83: 471 | Lee SA, Cancer Lett 2003; 198: 187 | Lee SJ,
Int J Med Sci 2012; 9: 103 | Oh JK, Eur J Cancer Prev 2009; 18: 56 | Oh YL,
Cytopathology 2001; 12: 75 | Park EK, J Korean Med Sci 2014; 29: 32 | Shim
HS, BMC Infect Dis 2010; 10: 284 | Shin HR, Int J Cancer 2003; 103: 413 | Shin
HR, J Infect Dis 2004; 190: 468 | Um TH, Ann Clin Lab Sci 2011; 41: 48
Kuwait Al-Awadhi R, J Med Virol 2011; 83: 453
Laos Phongsavan K, Int J Gynecol Cancer 2012; 22: 1398
Lebanon Karam WG, Lebanese Medical Journal 2005; 53: 132 | Mroueh AM, Eur J
Gynaecol Oncol 2002; 23: 429
Mongolia Chimeddorj B, Asian Pac J Cancer Prev 2008; 9: 563 | Dondog B, Cancer
Epidemiol Biomarkers Prev 2008; 17: 1731
Malaysia Chong PP, Asian Pac J Cancer Prev 2010; 11: 1645 | Othman N, Asian Pac J
Cancer Prev 2014; 15: 2245 | Tay SK, Aust N Z J Obstet Gynaecol 2009; 49: 323
Nepal Johnson DC, PLoS ONE 2014; 9: e101255 | Sherpa AT, Cancer Causes Control
2010; 21: 323
Pakistan Raza SA, Br J Cancer 2010; 102: 1657
Philippines Ngelangel C, J Natl Cancer Inst 1998; 90: 43
Saudi Arabia Al-Ahdal MN, J Infect Dev Ctries 2014; 8: 320
Thailand Chaiwongkot A, Asian Pac J Cancer Prev 2007; 8: 279 | Chandeying V, Sex
Health 2006; 3: 11 | Chansaenroj J, Asian Pac J Cancer Prev 2010; 11: 117 |
Chichareon S, J Natl Cancer Inst 1998; 90: 50 | Chopjitt P, Int J Infect Dis 2009;
13: 212 | Ekalaksananan T, J Obstet Gynaecol Res 2010; 36: 1037 |
Laowahutanont P, Asian Pac J Cancer Prev 2014; 15: 5879 | Marks M, Int J
Cancer 2011; 128: 2962 | Natphopsuk S, Asian Pac J Cancer Prev 2013; 14: 6961
| Paengchit K, Asian Pac J Cancer Prev 2014; 15: 6151 | Settheetham-Ishida W,
Microbiol Immunol 2005; 49: 417 | Siriaunkgul S, Asian Pac J Cancer Prev
2014; 15: 6837 | Siritantikorn S, Southeast Asian J Trop Med Public Health
1997; 28: 707 | Sriamporn S, Int J Gynecol Cancer 2006; 16: 266 | Sukvirach S,
J Infect Dis 2003; 187: 1246 | Suwannarurk K, Cancer Epidemiol 2009; 33: 56 |
Swangvaree SS, Asian Pac J Cancer Prev 2010; 11: 1465 | Thomas DB, Am J
Epidemiol 2001; 153: 723 | Wongworapat K, Sex Transm Dis 2008; 35: 172
Turkey Akcali S, Asian Pac J Cancer Prev 2013; 14: 503 | Altun 2011: reported in
Vaccarella S, Vaccine 2013; 31 Suppl 6: G32 | Bayram A, J Med Virol 2011; 83:
1997 | Demir ET, J Med Virol 2012; 84: 1242 | Dursun P, BMC Infect Dis 2009;
9: 191 | Eren F, Int J Gynaecol Obstet 2010; 109: 235 | Inal MM, Int J Gynecol
Cancer 2007; 17: 1266 | Kasap B, Eur J Obstet Gynecol Reprod Biol 2011; 159:
168 | Ozalp SS, J Turk Ger Gynecol Assoc 2012; 13: 8 | Oztrk S, Mikrobiyol
Bul 2004; 38: 223 | Sahiner F, Diagn Microbiol Infect Dis 2014; 80: 43 | Sahiner
F, J Microbiol Methods 2014; 97: 44 | Tezcan S, Asian Pac J Cancer Prev 2014;
15: 3997 | Yuce K, Arch Gynecol Obstet 2012; 286: 203 | zcan ES, J Obstet
Gynaecol 2011; 31: 656
(Continued)
Table 32 Continued
Country Study
Taiwan Chen HC, Int J Cancer 2011; 128: 1192 | Huang YK, Br J Cancer 2008; 98: 863
| Jeng CJ, Clin Invest Med 2005; 28: 261 | Lai CH, Epidemiol Infect 2012; 140:
466 | Liaw KL, Int J Cancer 1995; 62: 565 | Lin H, Gynecol Oncol 2005; 96: 84 |
Lin H, Gynecol Oncol 2006; 101: 40 | Tsai HT, Cancer Epidemiol Biomarkers
Prev 2005; 14: 2544 | Wang CH, J Med Virol 2010; 82: 1416
Uzbekistan Inamova 2009: reported in De Vuyst H, Vaccine 2013; 31 Suppl 5: F32
Viet Nam Pham TH, Int J Cancer 2003; 104: 213 | Vu LT, Asian Pac J Cancer Prev 2011;
12: 561 | Vu LT, Asian Pac J Cancer Prev 2012; 13: 37 | Vu LT, Western Pac
Surveill Response J 2012; 3: 57
Europe
Belgium Arbyn M, Cancer Epidemiol Biomarkers Prev 2009; 18: 321 | Baay MF, Eur J
Cancer 2005; 41: 2704 | Baay MF, Eur J Gynaecol Oncol 2001; 22: 204 |
Depuydt CE, Br J Cancer 2003; 88: 560 | Depuydt CE, Gynecol Obstet Invest
2010; 70: 273 | Depuydt CE, J Clin Microbiol 2012; 50: 4073 | Merckx M, Eur J
Cancer Prev 2014; 23: 288 | Schmitt M, Int J Cancer 2013; 132: 2395 | Weyn C,
Cancer Epidemiol 2013; 37: 457
Bulgaria Kovachev S, J Med Virol 2013; 85: 1577
Belarus Rogovskaya SI, Vaccine 2013; 31 Suppl 7: H46
Switzerland Bigras G, Br J Cancer 2005; 93: 575
Czech Republic Tachezy R, PLoS ONE 2013; 8: e79156
Germany de Jonge M, Acta Cytol 2013; 57: 591 | Iftner T, J Med Virol 2010; 82: 1928 |
Luyten A, Int J Cancer 2014; 135: 1408 | Petry KU, BMC Infect Dis 2013; 13:
135 | Petry KU, Br J Cancer 2003; 88: 1570 | Schneider A, Int J Cancer 2000;
89: 529
Denmark Bonde J, BMC Infect Dis 2014; 14: 413 | Kjr SK, Cancer Causes Control 2014;
25: 179 | Nielsen A, Sex Transm Dis 2008; 35: 276 | Svare EI, Eur J Cancer
1998; 34: 1230
Spain Bernal M, Infect Agents Cancer 2008; 3: 8 | Castellsagu X, J Med Virol 2012;
84: 947 | de Sanjose S, Sex Transm Dis 2003; 30: 788 | Dillner J, BMJ 2008;
337: a1754 | Gonzlez C, Sex Transm Infect 2006; 82: 260 | Lloveras B, PLoS
ONE 2013; 8: e58153 | Martorell M, Scand J Infect Dis 2010; 42: 549 | Muoz
N, Sex Transm Dis 1996; 23: 504 | Ortiz M, J Clin Microbiol 2006; 44: 1428
Estonia Uuskla A, BMC Infect Dis 2010; 10: 63
Finland Auvinen E, Scand J Infect Dis 2005; 37: 873 | Malila N, Int J Cancer 2013; 132:
2141
France Baudu A, J Epidemiol Glob Health 2014; 4: 35 | Beby-Defaux A, J Med Virol
2004; 73: 262 | Boulanger JC, Gynecol Obstet Fertil 2004; 32: 218 | Casalegno
JS, Int J Gynaecol Obstet 2011; 114: 116 | Clavel C, Br J Cancer 2001; 84: 1616
| Dalstein V, Int J Cancer 2003; 106: 396 | Haguenoer K, Gynecol Oncol 2014;
134: 302 | Heard I, PLoS ONE 2013; 8: e79372 | Monsonego J, Gynecol Oncol
2005; 99: 160 | Monsonego J, Int J Cancer 2011; 129: 691 | Pannier-Stockman
C, J Clin Virol 2008; 42: 353 | Riethmuller D, Diagn Mol Pathol 1999; 8: 157 |
Vaucel E, Arch Gynecol Obstet 2011; 284: 989
United Kingdom Cuschieri KS, J Clin Pathol 2004; 57: 68 | Cuzick J, Br J Cancer 1999; 81: 554 |
Cuzick J, Lancet 1995; 345: 1533 | Cuzick J, Lancet 2003; 362: 1871 | Geraets
DT, J Clin Microbiol 2014; 52: 3996 | Grainge MJ, Emerging Infect Dis 2005; 11:
1680 | Herbert A, J Fam Plann Reprod Health Care 2007; 33: 171 | Hibbitts S,
Br J Cancer 2008; 99: 1929 | Hibbitts S, J Clin Virol 2014; 59: 109 |
Howell-Jones R, Br J Cancer 2010; 103: 209 | Kavanagh K, Br J Cancer 2014;
110: 2804 | Kitchener HC, Br J Cancer 2006; 95: 56 | Peto J, Br J Cancer 2004;
91: 942
Greece Agorastos T, Eur J Cancer Prev 2004; 13: 145 | Agorastos T, Eur J Cancer Prev
2014; 23: 425 | Agorastos T, PLoS ONE 2015; 10: e0119755 | Argyri E, BMC
Infect Dis 2013; 13: 53 | Panotopoulou E, J Med Virol 2007; 79: 1898 |
Paraskevaidis E, Gynecol Oncol 2001; 82: 355 | Tsiodras S, BMC Cancer 2010;
10: 53 | Tsiodras S, Clin Microbiol Infect 2011; 17: 1185
(Continued)
Table 32 Continued
Country Study
Croatia Grahovac M, Coll Antropol 2007; 31 Suppl 2: 73 | Kaliterna V, Cent Eur J Public
Health 2013; 21: 26 | Kaliterna V, Coll Antropol 2007; 31 Suppl 2: 79
Hungary Nyri T, Eur J Obstet Gynecol Reprod Biol 2006; 126: 246
Ireland Anderson L, J Med Virol 2013; 85: 295 | Keegan H, Br J Biomed Sci 2007; 64: 18
Italy Agarossi A, J Med Virol 2009; 81: 529 | Ammatuna P, Cancer Epidemiol
Biomarkers Prev 2008; 17: 2002 | Astori G, Virus Res 1997; 50: 57 | Barzon L, J
Med Virol 2010; 82: 1424 | Bellaminutti S, J Med Virol 2014; 86: 1920 | Carozzi
F, Br J Cancer 2000; 83: 1462 | Carozzi F, J Clin Virol 2014; 60: 257 |
Centurioni MG, BMC Infect Dis 2005; 5: 77 | Del Mistro A, J Med Screen 2014;
21: 30 | Del Prete R, J Clin Virol 2008; 42: 211 | Giambi C, BMC Infect Dis
2013; 13: 74 | Giorgi Rossi P, Infect Agents Cancer 2011; 6: 2 | Masia G, Vaccine
2009; 27 Suppl 1: A11 | Panatto D, BMC Infect Dis 2013; 13: 575 | Piana A,
BMC Public Health 2011; 11: 785 | Ronco G, Eur J Cancer 2005; 41: 297 | Salfa
MC, Ig Sanita Pubbl 2011; 67: 425 | Sammarco ML, Eur J Obstet Gynecol
Reprod Biol 2013; 168: 222 | Tenti P, J Infect Dis 1997; 176: 277 | Tornesello
ML, J Gen Virol 2008; 89: 1380 | Tornesello ML, J Med Virol 2006; 78: 1663 |
Verteramo R, BMC Infect Dis 2009; 9: 16 | Zappacosta B, New Microbiol 2009;
32: 351
Lithuania Bumbuliene Z, Acta Obstet Gynecol Scand 2012; 91: 511 | Gudleviciene Z,
Medicina (Kaunas) 2005; 41: 910 | Kliucinskas M, Gynecol Obstet Invest 2006;
62: 173 | Simanaviciene V, J Med Virol 2014
Latvia Silins I, Gynecol Oncol 2004; 93: 484
Montenegro Vujosevic D, Acta Medica (Hradec Kralove) 2012; 55: 130
Netherlands Boers A, PLoS ONE 2014; 9: e101930 | Bulkmans NW, Int J Cancer 2004; 110:
94 | Hesselink AT, J Clin Microbiol 2013; 51: 2409 | Jacobs MV, Int J Cancer
2000; 87: 221 | Lenselink CH, PLoS ONE 2008; 3: e3743 | Rijkaart DC, Br J
Cancer 2012; 106: 975 | Rijkaart DC, Lancet Oncol 2012; 13: 78 | Rozendaal L,
J Clin Pathol 2000; 53: 606 | Zielinski GD, Br J Cancer 2001; 85: 398
Norway Gjoen K, APMIS 1996; 104: 68 | Molden T, Cancer Epidemiol Biomarkers Prev
2005; 14: 367 | Molden T, Gynecol Oncol 2006; 100: 95 | Skjeldestad FE, Acta
Obstet Gynecol Scand 2008; 87: 81
Poland Bardin A, Eur J Cancer 2008; 44: 557
Portugal Dutra I, Infect Agents Cancer 2008; 3: 6 | Pista A, Clin Microbiol Infect 2011;
17: 941 | Pista A, Int J Gynecol Cancer 2011; 21: 1150 | Vieira L, Eur J
Microbiol Immunol (Bp) 2013; 3: 61
Romania Moga MA, Asian Pac J Cancer Prev 2014; 15: 6887 | Ursu RG, Virol J 2011; 8:
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Russian Federation Alexandrova YN, Cancer Lett 1999; 145: 43 | Bdaizieva 2010: reported in De
Vuyst H, Vaccine 2013; 31 Suppl 5: F32 | Goncharevskaya 2011: reported in De
Vuyst H, Vaccine 2013; 31 Suppl 5: F32 | Komarova 2010: reported in De Vuyst
H, Vaccine 2013; 31 Suppl 5: F32 | Kubanov 2005: reported in De Vuyst H,
Vaccine 2013; 31 Suppl 5: F32 | Rogovskaya SI, Vaccine 2013; 31 Suppl 7: H46 |
Shargorodskaya 2011: reported in De Vuyst H, Vaccine 2013; 31 Suppl 5: F32 |
Shipitsyna E, Cancer Epidemiol 2011; 35: 160 | Shipulina 2011: reported in De
Vuyst H, Vaccine 2013; 31 Suppl 5: F32
Slovenia Ucakar V, J Med Virol 2014; 86: 1772 | Ucakar V, Vaccine 2012; 30: 116
Sweden Elfstrm KM, BMJ 2014; 348: g130 | Gyllensten U, Gynecol Oncol 2012; 125:
343 | Kjellberg L, Am J Obstet Gynecol 1998; 179: 1497 | Naucler P, N Engl J
Med 2007; 357: 1589 | Stenvall H, Acta Derm Venereol 2007; 87: 243 | Ylitalo
N, Cancer Res 2000; 60: 6027
Oceania
Australia Bowden FJ, Sex Health 2005; 2: 229 | Tabrizi SN, J Clin Virol 2014; 60: 250 |
Tabrizi SN, Lancet Infect Dis 2014; 14: 958
Fiji Foliaki S, Infect Agents Cancer 2014; 9: 14
(Continued)
Table 32 Continued
Country Study
Vanuatu Aruhuri B, Cancer Prev Res (Phila) 2012; 5: 746 | McAdam M, PLoS ONE 2010;
5: e13266
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Ethiopia Contributing studies: Abate E, J Med Virol 2013; 85: 282 | Fanta BE, Ethiop
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Mali Contributing studies: Bayo S, Int J Epidemiol 2002; 31: 202 | Bosch FX, J Natl
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Mozambique Contributing studies: Castellsagu X, Int J Cancer 2008; 122: 1901 | Naucler P,
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Senegal Contributing studies: Lin P, Cancer Epidemiol Biomarkers Prev 2001; 10: 1037
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Argentina Contributing studies: Alonio LV, J Clin Virol 2003; 27: 263 | Bosch FX, J Natl
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E, Acta Obstet Gynecol Scand 1997; 76: 271
Bolivia Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796
Brazil Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Cambruzzi
E, Pathol Oncol Res 2005; 11: 114 | de Oliveira CM, BMC Cancer 2013; 13: 357
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(Continued)
Table 32 Continued
Country Study
Canada Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Duggan MA,
Hum Pathol 1995; 26: 319 | Tran-Thanh D, Am J Obstet Gynecol 2003; 188: 129
Chile Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Roa JC, Int
J Gynaecol Obstet 2009; 105: 150 | Valdivia L IM, Rev Chilena Infectol 2010; 27:
11
Colombia Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 |
Moreno-Acosta P, Virus Genes 2008; 37: 22 | Murillo R, Infect Dis Obstet
Gynecol 2009; 2009: 653598 | Muoz N, Int J Cancer 1992; 52: 743
Costa Rica Contributing studies: Herrero R, J Infect Dis 2005; 191: 1796
Cuba Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796
Ecuador Contributing studies: Meja L, J Med Virol 2016; 88: 144
Honduras Contributing studies: Ferreira M, Mod Pathol 2008; 21: 968
Jamaica Contributing studies: Strickler HD, J Med Virol 1999; 59: 60
Mexico Contributing studies: Aguilar-Lemarroy A, J Med Virol 2015; 87: 871 |
Alarcn-Romero Ldel C, Salud Publica Mex 2009; 51: 134 | Carrillo-Garca A,
Gynecol Oncol 2014; 134: 534 | Flores-Miramontes MG, Virol J 2015; 12: 161 |
Gonzlez-Losa Mdel R, J Clin Virol 2004; 29: 202 | Guardado-Estrada M, PLoS
ONE 2014; 9: e109406 | Illades-Aguiar B, Cancer Detect Prev 2009; 32: 300 |
Meyer T, J Infect Dis 1998; 178: 252 | Pia-Snchez P, Int J Gynecol Cancer
2006; 16: 1041 | Serrano B, Cancer Epidemiol 2014 | Torroella-Kouri M,
Gynecol Oncol 1998; 70: 115 | Velzquez-Mrquez N, Int J Infect Dis 2009; 13:
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Nicaragua Contributing studies: Hindryckx P, Sex Transm Infect 2006; 82: 334
Panama Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796
Peru Contributing studies: Martorell M, Genet Mol Res 2012; 11: 2099 | Santos C, Br
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Paraguay Contributing studies: Kasamatsu E, J Med Virol 2012; 84: 1628 | Roln PA, Int
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Suriname Contributing studies: De Boer MA, Int J Cancer 2005; 114: 422
Trinidad & Tobago Contributing studies: Hosein F, Rev Panam Salud Publica 2013; 33: 267
USA Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Bryan JT, J
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390 | Resnick RM, J Natl Cancer Inst 1990; 82: 1477 | Schwartz SM, J Clin
Oncol 2001; 19: 1906 | Sebbelov AM, Microbes Infect 2000; 2: 121 | Wentzensen
N, Int J Cancer 2009; 124: 964 | Wheeler CM, J Natl Cancer Inst 2009; 101: 475
| Wistuba II, Cancer Res 1997; 57: 3154 | Zuna RE, Mod Pathol 2007; 20: 167
Venezuela Contributing studies: Snchez-Lander J, Cancer Epidemiol 2012; 36: e284
Asia
Bangladesh Contributing studies: Banik U, Cytojournal 2013; 10: 14
(Continued)
Table 32 Continued
Country Study
China Contributing studies: Cai HB, Eur J Gynaecol Oncol 2008; 29: 72 | Cai HB,
Oncology 2009; 76: 157 | Chan PK, Int J Cancer 2009; 125: 1671 | Chan PK, Int
J Cancer 2012; 131: 692 | Chen W, Cancer Causes Control 2009; 20: 1705 | Ding
X, J Med Virol 2014; 86: 1937 | Gao YE, Sheng Wu Hua Xue Yu Sheng Wu Wu
Li Xue Bao 2003; 35: 1029 | Hong D, Int J Gynecol Cancer 2008; 18: 104 |
Huang S, Int J Cancer 1997; 70: 408 | Li H, Eur J Obstet Gynecol Reprod Biol
2013; 170: 202 | Lin QQ, Int J Cancer 1998; 75: 484 | Liu GB, J First Mil Med
Univ 2005; 25: 1236 | Liu J, Gynecol Oncol 2004; 94: 803 | Liu SS, Tumour Biol
2008; 29: 105 | Liu X, Int J Gynecol Cancer 2010; 20: 147 | Lo KW, Gynecol
Obstet Invest 2001; 51: 202 | Lo KW, Int J Cancer 2002; 100: 327 | Peng HQ,
Int J Cancer 1991; 47: 711 | Qiu AD, Gynecol Oncol 2007; 104: 77 | Serrano B,
Cancer Epidemiol 2014 | Shah W, Clin Oncol (R Coll Radiol) 2009; 21: 768 |
Stephen AL, Int J Cancer 2000; 86: 695 | Tao PP, Zhonghua Fu Chan Ke Za Zhi
2006; 41: 43 | Wang L, J Med Virol 2015; 87: 516 | Wu EQ, BMC Cancer 2008;
8: 202 | Wu EQ, Int J Gynecol Cancer 2009; 19: 919 | Wu Y, J Med Virol 2008;
80: 1808 | Yu MY, Int J Cancer 2003; 105: 204 | Yuan X, Arch Gynecol Obstet
2011; 283: 1385 | Zhao Y, Pathol Int 2008; 58: 643
Georgia Contributing studies: Alibegashvili T, Cancer Epidemiol 2011; 35: 465
Indonesia Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 | De Boer MA,
Int J Cancer 2005; 114: 422 | Schellekens MC, Gynecol Oncol 2004; 93: 49 |
Tobing MD, Asian Pac J Cancer Prev 2014; 15: 5781
India Contributing studies: Basu P, Asian Pac J Cancer Prev 2009; 10: 27 | Bhatla N,
Int J Gynecol Pathol 2006; 25: 398 | Deodhar K, J Med Virol 2012; 84: 1054 |
Franceschi S, Int J Cancer 2003; 107: 127 | Gheit T, Vaccine 2009; 27: 636 |
Munagala R, Int J Oncol 2009; 34: 263 | Munirajan AK, Gynecol Oncol 1998; 69:
205 | Munjal K, Int J Gynecol Pathol 2014; 33: 531 | Nagpal JK, Eur J Clin
Invest 2002; 32: 943 | Nair P, Pathol Oncol Res 1999; 5: 95 | Nambaru L, Asian
Pac J Cancer Prev 2009; 10: 355 | Neyaz MK, Biomarkers 2008; 13: 597 |
Peedicayil A, Int J Gynecol Cancer 2006; 16: 1591 | Peedicayil A, J Low Genit
Tract Dis 2009; 13: 102 | Serrano B, Cancer Epidemiol 2014 | Sowjanya AP,
BMC Infect Dis 2005; 5: 116
Iran Contributing studies: Esmaeili M, Gynecol Obstet Invest 2008; 66: 68 | Ghaffari
SR, Asian Pac J Cancer Prev 2006; 7: 529 | Hamkar R, East Mediterr Health J
2002; 8: 805 | Khodakarami N, Int J Cancer 2012; 131: E156 | Mortazavi S,
Asian Pac J Cancer Prev 2002; 3: 69 | Salehi-Vaziri M, Arch Virol 2015; 160:
1181
Israel Contributing studies: Bassal R, J Low Genit Tract Dis 2015; 19: 161 | Laskov I,
Int J Gynecol Cancer 2013; 23: 730
Jordan Contributing studies: Sughayer MA, Int J Gynaecol Obstet 2010; 108: 74
Japan Contributing studies: Asato T, J Infect Dis 2004; 189: 1829 | Azuma Y, Jpn J
Clin Oncol 2014 | Fujinaga Y, J Gen Virol 1991; 72 ( Pt 5): 1039 | Harima Y, Int
J Radiat Oncol Biol Phys 2002; 52: 1345 | Imajoh M, Virol J 2012; 9: 154 |
Inoue M, Int J Gynecol Cancer 2006; 16: 1007 | Ishikawa H, Cancer 2001; 91: 80
| Kanao H, Cancer Lett 2004; 213: 31 | Kashiwabara K, Acta Pathol Jpn 1992;
42: 876 | Maehama T, Infect Dis Obstet Gynecol 2005; 13: 77 | Maki H, Jpn J
Cancer Res 1991; 82: 411 | Nakagawa H, Anticancer Res 2002; 22: 1655 |
Nakagawa S, Cancer 1996; 78: 1935 | Nawa A, Cancer 1995; 75: 518 | Onuki M,
Cancer Sci 2009; 100: 1312 | Saito J, Gynecol Obstet Invest 2000; 49: 190 |
Sasagawa T, Cancer Epidemiol Biomarkers Prev 2001; 10: 45 | Takehara K,
Patholog Res Int 2011; 2011: 246936 | Tsuda H, Gynecol Oncol 2003; 91: 476 |
Watari H, Pathobiology 2011; 78: 220 | Yamakawa Y, Gynecol Oncol 1994; 53:
190 | Yamasaki K, J Obstet Gynaecol Res 2011; 37: 1666 | Yoshida T, Cancer
2004; 102: 100 | Yoshida T, Virchows Arch 2009; 455: 253
(Continued)
Table 32 Continued
Country Study
Republic of Korea Contributing studies: An HJ, Cancer 2003; 97: 1672 | An HJ, Mod Pathol 2005;
18: 528 | Cho NH, Am J Obstet Gynecol 2003; 188: 56 | Hwang T, J Korean Med
Sci 1999; 14: 593 | Hwang TS, Gynecol Oncol 2003; 90: 51 | Kim JY, J Clin
Oncol 2009; 27: 5088 | Kim KH, Yonsei Med J 1995; 36: 412 | Lee HS, Int J
Gynecol Cancer 2007; 17: 497 | Oh JK, Asian Pac J Cancer Prev 2010; 11: 993 |
Quek SC, Int J Gynecol Cancer 2013; 23: 148 | Song ES, J Korean Med Sci 2007;
22: 99 | Tong SY, Int J Gynecol Cancer 2007; 17: 1307
Kuwait Contributing studies: Al-Awadhi R, Diagn Cytopathol 2013; 41: 107
Sri Lanka Contributing studies: Karunaratne K, BMC Cancer 2014; 14: 116 |
Samarawickrema NA, Int J Gynaecol Obstet 2011; 115: 180
Myanmar Contributing studies: Mu-Mu-Shwe, Acta Med Okayama 2014; 68: 79
Mongolia Contributing studies: Chimeddorj B, Asian Pac J Cancer Prev 2008; 9: 563
Malaysia Contributing studies: Cheah PL, Malays J Pathol 2008; 30: 37 | Hamzi Abdul
Raub S, Asian Pac J Cancer Prev 2014; 15: 651 | Quek SC, Int J Gynecol Cancer
2013; 23: 148 | Sharifah NA, Asian Pac J Cancer Prev 2009; 10: 303 | Yadav M,
Med J Malaysia 1995; 50: 64
Nepal Contributing studies: Sherpa AT, Cancer Causes Control 2010; 21: 323
Pakistan Contributing studies: Khan S, Int J Infect Dis 2007; 11: 313 | Raza SA, Br J
Cancer 2010; 102: 1657
Philippines Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Ngelangel C,
J Natl Cancer Inst 1998; 90: 43 | Quek SC, Int J Gynecol Cancer 2013; 23: 148
Saudi Arabia Contributing studies: Alsbeih G, Gynecol Oncol 2011; 121: 522
Singapore Contributing studies: Quek SC, Int J Gynecol Cancer 2013; 23: 148
Syria Contributing studies: Darnel AD, Clin Microbiol Infect 2010; 16: 262
Thailand Contributing studies: Bhattarakosol P, J Med Assoc Thai 1996; 79 Suppl 1: S56
| Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Chansaenroj J, J Med Virol 2014;
86: 601 | Chichareon S, J Natl Cancer Inst 1998; 90: 50 | Chopjitt P, Int J Infect
Dis 2009; 13: 212 | Natphopsuk S, Asian Pac J Cancer Prev 2013; 14: 6961 |
Settheetham-Ishida W, Microbiol Immunol 2005; 49: 417 | Siriaunkgul S,
Gynecol Oncol 2008; 108: 555 | Siritantikorn S, Southeast Asian J Trop Med
Public Health 1997; 28: 707
Turkey Contributing studies: Ozgul N, J Obstet Gynaecol Res 2008; 34: 865 | Usubtn
A, Int J Gynecol Pathol 2009; 28: 541
Taiwan Contributing studies: Chao A, Int J Gynecol Pathol 2009; 28: 279 | Chen SL,
Cancer 1993; 72: 1939 | Chen TM, Int J Cancer 1994; 57: 181 | Ding DC, Eur J
Obstet Gynecol Reprod Biol 2008; 140: 245 | Ho CM, Gynecol Oncol 2005; 99:
615 | Huang HJ, Int J Gynecol Cancer 2004; 14: 639 | Huang LW, J Clin Virol
2004; 29: 271 | Lai CH, Int J Cancer 2007; 120: 1999 | Lai HC, Int J Cancer
1999; 84: 553 | Lin H, Gynecol Oncol 2005; 96: 84 | Su TH, Carcinogenesis
2007; 28: 1237 | Yang YC, Gynecol Oncol 1997; 64: 59 | Yang YY, J Microbiol
Immunol Infect 2004; 37: 282
Viet Nam Contributing studies: Quek SC, Int J Gynecol Cancer 2013; 23: 148
Europe
Austria Contributing studies: Bachtiary B, Int J Cancer 2002; 102: 237 | Widschwendter
A, Cancer Lett 2003; 202: 231
Belgium Contributing studies: Baay MF, Eur J Gynaecol Oncol 2001; 22: 204 | Beerens
E, Cytopathology 2005; 16: 199
Bulgaria Contributing studies: Todorova I, J Clin Pathol 2010; 63: 1121
Bosnia & Herzegovina Contributing studies: Iljazovi? E, Cancer Epidemiol 2014; 38: 504
Belarus Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771
Czech Republic Contributing studies: Slama J, Int J Gynecol Cancer 2009; 19: 703 | Tachezy R,
J Med Virol 1999; 58: 378 | Tachezy R, PLoS ONE 2011; 6: e21913
Germany Contributing studies: Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Klug SJ, J
Med Virol 2007; 79: 616 | Milde-Langosch K, Int J Cancer 1995; 63: 639
(Continued)
Table 32 Continued
Country Study
Denmark Contributing studies: Hording U, APMIS 1997; 105: 313 | Kirschner B, Acta
Obstet Gynecol Scand 2013; 92: 1023 | Kjaer SK, Int J Cancer 2008; 123: 1864 |
Kjr SK, Cancer Causes Control 2014; 25: 179 | Sebbelov AM, Microbes Infect
2000; 2: 121
Spain Contributing studies: Alemany L, Gynecol Oncol 2012; 124: 512 | Bosch FX, J
Natl Cancer Inst 1995; 87: 796 | Darwich L, Int J Gynecol Cancer 2011; 21:
1486 | Gonzlez-Bosquet E, Gynecol Oncol 2008; 111: 9 | Herraez-Hernandez E,
J Virol Methods 2013; 193: 9 | Martr E, Enferm Infecc Microbiol Clin 2012; 30:
225 | Mazarico E, Gynecol Oncol 2012; 125: 181 | Muoz N, Int J Cancer 1992;
52: 743 | Rodriguez JA, Diagn Mol Pathol 1998; 7: 276
Finland Contributing studies: Iwasawa A, Cancer 1996; 77: 2275
France Contributing studies: de Cremoux P, Int J Cancer 2009; 124: 778 | Lombard I, J
Clin Oncol 1998; 16: 2613 | Prtet JL, Int J Cancer 2008; 122: 424 | Riou G,
Lancet 1990; 335: 1171
United Kingdom Contributing studies: Arends MJ, Hum Pathol 1993; 24: 432 | Crook T, Lancet
1992; 339: 1070 | Cuschieri K, Br J Cancer 2010; 102: 930 | Cuschieri K, Int J
Cancer 2014; 135: 2721 | Cuzick J, Br J Cancer 2000; 82: 1348 | Giannoudis A,
Int J Cancer 1999; 83: 66 | Howell-Jones R, Br J Cancer 2010; 103: 209 |
Mesher D, J Clin Pathol 2015; 68: 135 | Powell N, Int J Cancer 2009; 125: 2425
| Sargent A, Br J Cancer 2008; 98: 1704 | Tawfik El-Mansi M, Int J Gynecol
Cancer 2006; 16: 1025
Greece Contributing studies: Adamopoulou M, Anticancer Res 2009; 29: 3401 |
Daponte A, J Clin Virol 2006; 36: 189 | Dokianakis DN, Oncol Rep 1999; 6: 1327
| Koffa M, Int J Oncol 1994; 5: 189 | Labropoulou V, Sex Transm Dis 1997; 24:
469 | Panotopoulou E, J Med Virol 2007; 79: 1898
Croatia Contributing studies: Dabic MM, Acta Obstet Gynecol Scand 2008; 87: 366 |
Hadzisejdic I, Coll Antropol 2006; 30: 879
Hungary Contributing studies: Knya J, J Med Virol 1995; 46: 1
Ireland Contributing studies: Butler D, J Pathol 2000; 192: 502 | Fay J, J Med Virol
2009; 81: 897 | OLeary JJ, J Clin Pathol 1998; 51: 576 | Skyldberg BM, Mod
Pathol 1999; 12: 675
Iceland Contributing studies: Sigurdsson K, Int J Cancer 2007; 121: 2682
Italy Contributing studies: Carozzi FM, Cancer Epidemiol Biomarkers Prev 2010; 19:
2389 | Ciotti M, Oncol Rep 2006; 15: 143 | Del Mistro A, Infect Agents Cancer
2006; 1: 9 | Gargiulo F, Virus Res 2007; 125: 176 | Garzetti GG, Cancer 1998;
82: 886 | Lillo F, J Low Genit Tract Dis 2008; 12: 204 | Mariani L, BMC Cancer
2010; 10: 259 | Rolla M, Eur J Gynaecol Oncol 2009; 30: 557 | Sideri M, Vaccine
2009; 27 Suppl 1: A30 | Spinillo A, J Med Virol 2014; 86: 1145 | Tornesello ML,
Gynecol Oncol 2011; 121: 32 | Tornesello ML, J Med Virol 2006; 78: 1663 |
Venturoli S, J Med Virol 2008; 80: 1434 | Voglino G, Pathologica 2000; 92: 516
Lithuania Contributing studies: Gudleviciene Z, Medicina (Kaunas) 2005; 41: 910 |
Simanaviciene V, J Med Virol 2014
Luxembourg Contributing studies: Ressler S, Clin Cancer Res 2007; 13: 7067
Latvia Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771 | Silins I, Gynecol
Oncol 2004; 93: 484
Netherlands Contributing studies: Baalbergen A, Gynecol Oncol 2013; 128: 530 | Baay MF, J
Clin Microbiol 1996; 34: 745 | Bulk S, Br J Cancer 2006; 94: 171 | Bulkmans
NW, Int J Cancer 2005; 117: 177 | De Boer MA, Int J Cancer 2005; 114: 422 |
Krul EJ, Int J Gynecol Cancer 1999; 9: 206 | Resnick RM, J Natl Cancer Inst
1990; 82: 1477 | Tang N, J Clin Virol 2009; 45 Suppl 1: S25 | Van Den Brule AJ,
Int J Cancer 1991; 48: 404 | Zielinski GD, J Pathol 2003; 201: 535
Norway Contributing studies: Bertelsen BI, Virchows Arch 2006; 449: 141 | Karlsen F, J
Clin Microbiol 1996; 34: 2095
(Continued)
Table 32 Continued
Country Study
Poland Contributing studies: Baay MF, Eur J Gynaecol Oncol 2009; 30: 162 | Bardin A,
Eur J Cancer 2008; 44: 557 | Biesaga B, Folia Histochem Cytobiol 2012; 50: 239
| Bosch FX, J Natl Cancer Inst 1995; 87: 796 | Dybikowska A, Oncol Rep 2002;
9: 871 | Kwasniewska A, Eur J Gynaecol Oncol 2009; 30: 65 | Pirog EC, Am J
Pathol 2000; 157: 1055
Portugal Contributing studies: Medeiros R, Eur J Cancer Prev 2005; 14: 467 | Nobre RJ,
J Med Virol 2010; 82: 1024 | Pista A, Int J Gynecol Cancer 2013; 23: 500
Russian Federation Contributing studies: Kleter B, J Clin Microbiol 1999; 37: 2508 | Kulmala SM, J
Med Virol 2007; 79: 771
Slovenia Contributing studies: Jancar N, Eur J Obstet Gynecol Reprod Biol 2009; 145:
184
Sweden Contributing studies: Andersson S, Acta Obstet Gynecol Scand 2003; 82: 960 |
Andersson S, Cancer Detect Prev 2005; 29: 37 | Andersson S, Eur J Cancer
2001; 37: 246 | Du J, Acta Oncol 2011; 50: 1215 | Graflund M, Int J Gynecol
Cancer 2004; 14: 896 | Hagmar B, Med Oncol Tumor Pharmacother 1992; 9: 113
| Skyldberg BM, Mod Pathol 1999; 12: 675 | Wallin KL, N Engl J Med 1999;
341: 1633 | Zehbe I, J Pathol 1997; 181: 270
Oceania
Australia Contributing studies: Brestovac B, J Med Virol 2005; 76: 106 | Chen S, Int J
Gynaecol Obstet 1999; 67: 163 | de Sanjose S, Lancet Oncol 2010; 11: 1048 | Liu
J, Gynecol Oncol 2004; 94: 803 | Plunkett M, Pathology 2003; 35: 397 | Stevens
MP, Int J Gynecol Cancer 2006; 16: 1017 | Thompson CH, Gynecol Oncol 1994;
54: 40
Papua New Guinea Contributing studies: Tabone T, Int J Gynaecol Obstet 2012; 117: 30
HPV type distribution for cervical high grade squamous intraepithelial lesions
General sources Based on meta-analysis performed by IARCs Infections and Cancer
Epidemiology Group up to November 2011, the ICO HPV Information Centre
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Cancer 2012;131:2349 2) Smith JS, Int J Cancer 2007;121:621 3) Clifford GM, Br
J Cancer 2003;89:101.
Africa
Cte dIvoire Contributing studies: La Ruche G, Int J Cancer 1998; 76: 480
Cameroon Contributing studies: Untiet S, Int J Cancer 2014; 135: 1911
DR Congo Contributing studies: Hovland S, Br J Cancer 2010; 102: 957
Algeria Contributing studies: Hammouda D, Int J Cancer 2011; 128: 2224
Ethiopia Contributing studies: Abate E, J Med Virol 2013; 85: 282
Guinea Contributing studies: Keita N, Br J Cancer 2009; 101: 202
Equatorial Guinea Contributing studies: Garca-Espinosa B, Diagn Pathol 2009; 4: 31
Kenya Contributing studies: De Vuyst H, Cancer Causes Control 2010; 21: 2309 | De
Vuyst H, Int J Cancer 2012; 131: 949 | De Vuyst H, Sex Transm Dis 2003; 30:
137
Morocco Contributing studies: Alhamany Z, J Infect Dev Ctries 2010; 4: 732
Nigeria Contributing studies: Gage JC, Int J Cancer 2012; 131: 2903 | Haghshenas M,
Infect Agents Cancer 2013; 8: 20
Rwanda Contributing studies: Singh DK, J Infect Dis 2009; 199: 1851
Sudan Contributing studies: Abate E, J Med Virol 2013; 85: 282
Senegal Contributing studies: Chabaud M, J Med Virol 1996; 49: 259 | Xi LF, Int J
Cancer 2003; 103: 803
Tanzania Contributing studies: Dartell MA, Int J Cancer 2014; 135: 896
South Africa Contributing studies: Allan B, J Clin Microbiol 2008; 46: 740 | De Vuyst H, Int J
Cancer 2012; 131: 949 | Said HM, J Clin Virol 2009; 44: 318 | van Aardt MC,
Personal communication Unpublished
Zimbabwe Contributing studies: Sawaya GF, Obstet Gynecol 2008; 112: 990
(Continued)
Table 32 Continued
Country Study
Americas
Argentina Contributing studies: Abba MC, Rev Argent Microbiol 2003; 35: 74 | Alonio LV,
J Clin Virol 2003; 27: 263 | Chouhy D, Int J Mol Med 2006; 18: 995 | Deluca
GD, Rev Inst Med Trop Sao Paulo 2004; 46: 9 | Venezuela RF, Rev Inst Med
Trop Sao Paulo 2012; 54: 11
Belize Contributing studies: Cathro HP, Hum Pathol 2009; 40: 942
Brazil Contributing studies: Camara GN, Mem Inst Oswaldo Cruz 2003; 98: 879 |
Carestiato FN, Rev Soc Bras Med Trop 2006; 39: 428 | Chagas BS, PLoS ONE
2015; 10: e0132570 | Fernandes JV, BMC Res Notes 2010; 3: 96 | Fernandes JV,
Int J Gynaecol Obstet 2009; 105: 21 | Freitas TP, Rev Inst Med Trop Sao Paulo
2007; 49: 297 | Krambeck WM, Clin Exp Obstet Gynecol 2008; 35: 175 |
Lorenzato F, Int J Gynecol Cancer 2000; 10: 143 | Pitta DR, Rev Bras Ginecol
Obstet 2010; 32: 315 | Resende LS, BMC Infect Dis 2014; 14: 214 | Ribeiro AA,
Int J Gynecol Pathol 2011; 30: 288 | Terra AP, Tumori 2007; 93: 572 | Tomita
LY, Int J Cancer 2010; 126: 703
Canada Contributing studies: Antonishyn NA, Arch Pathol Lab Med 2008; 132: 54 |
Coutle F, J Med Virol 2011; 83: 1034 | Jiang Y, J Infect Public Health 2011; 4:
219 | Moore RA, Cancer Causes Control 2009; 20: 1387
Chile Contributing studies: Ili CG, J Med Virol 2011; 83: 833
Colombia Contributing studies: Bosch FX, Cancer Epidemiol Biomarkers Prev 1993; 2: 415
| Garca DA, Open Virol J 2011; 5: 70 | Muoz N, Int J Cancer 1992; 52: 743
Costa Rica Contributing studies: Herrero R, J Infect Dis 2005; 191: 1796
Cuba Contributing studies: Soto Y, Sex Transm Dis 2007; 34: 974
Ecuador Contributing studies: Meja L, J Med Virol 2016; 88: 144
Honduras Contributing studies: Ferreira M, Mod Pathol 2008; 21: 968
Jamaica Contributing studies: Rattray C, J Infect Dis 1996; 173: 718 | Strickler HD, J
Med Virol 1999; 59: 60
Mexico Contributing studies: Giuliano AR, Cancer Epidemiol Biomarkers Prev 2001; 10:
1129 | Illades-Aguiar B, Gynecol Oncol 2010; 117: 291 | Pia-Snchez P, Int J
Gynecol Cancer 2006; 16: 1041 | Torroella-Kouri M, Gynecol Oncol 1998; 70:
115 | Velzquez-Mrquez N, Int J Infect Dis 2009; 13: 690
Nicaragua Contributing studies: Hindryckx P, Sex Transm Infect 2006; 82: 334
Peru Contributing studies: Martorell M, Genet Mol Res 2012; 11: 2099
Paraguay Contributing studies: Mendoza LP, J Med Virol 2011; 83: 1351
USA Contributing studies: Adam E, Am J Obstet Gynecol 1998; 178: 1235 | Bell MC,
Gynecol Oncol 2007; 107: 236 | Castle PE, Cancer Epidemiol Biomarkers Prev
2010; 19: 1675 | Castle PE, Cancer Epidemiol Biomarkers Prev 2011; 20: 946 |
Einstein MH, Int J Cancer 2007; 120: 55 | Evans MF, Cancer 2006; 106: 1054 |
Evans MF, Eur J Gynaecol Oncol 2003; 24: 373 | Giuliano AR, Cancer Epidemiol
Biomarkers Prev 2001; 10: 1129 | Guo M, Mod Pathol 2007; 20: 256 | Hariri S,
J Infect Dis 2012; 206: 1878 | Hariri S, PLoS ONE 2012; 7: e34044 | Hu L, Mod
Pathol 2005; 18: 267 | Joste NE, Cancer Epidemiol Biomarkers Prev 2015; 24:
230 | Kong CS, Am J Surg Pathol 2007; 31: 33 | Lee SH, Int J Gynaecol Obstet
2009; 105: 210 | Moscicki AB, Obstet Gynecol 2008; 112: 1335 | Stoler MH, Am
J Clin Pathol 2011; 135: 468 | Vidal AC, Cancer Causes Control 2014; 25: 1055
| Voss JS, Anal Quant Cytol Histol 2009; 31: 208 | Wentzensen N, Int J Cancer
2009; 124: 964 | Wheeler CM, J Infect Dis 2006; 194: 1291 | Wheeler CM, J
Natl Cancer Inst 2009; 101: 475 | Zuna RE, Mod Pathol 2007; 20: 167
Venezuela Contributing studies: Snchez-Lander J, Cancer Epidemiol 2012; 36: e284
Asia
Bangladesh Contributing studies: Banik U, Cytojournal 2013; 10: 14
(Continued)
Table 32 Continued
Country Study
China Contributing studies: Chan MK, Gynecol Oncol 1996; 60: 217 | Chan PK, Int J
Cancer 2006; 118: 243 | Chan PK, Int J Cancer 2012; 131: 692 | Chan PK, J
Med Virol 1999; 59: 232 | Ding X, J Med Virol 2014; 86: 1937 | Guo J, Scand J
Infect Dis 2010; 42: 72 | Jin Q, Chin Med J 2010; 123: 2004 | Li H, Eur J Obstet
Gynecol Reprod Biol 2013; 170: 202 | Li J, Int J Gynaecol Obstet 2011; 112: 131
| Li J, J Clin Microbiol 2012; 50: 1079 | Liu SS, Tumour Biol 2008; 29: 105 |
Singh S, Int J Clin Exp Pathol 2015; 8: 11901 | Sun B, Arch Virol 2014; 159:
1027 | Tao PP, Zhonghua Fu Chan Ke Za Zhi 2006; 41: 43 | Wu CH, Sex Transm
Dis 1994; 21: 309 | Wu EQ, Cancer Causes Control 2013; 24: 795 | Yuan X, Arch
Gynecol Obstet 2011; 283: 1385 | Zhang R, Cancer Epidemiol 2013; 37: 939 |
Zhao FH, Int J Cancer 2014; 135: 2604 | Zhao Y, Pathol Int 2008; 58: 643
India Contributing studies: Deodhar K, J Med Virol 2012; 84: 1054 | Franceschi S, Br
J Cancer 2005; 92: 601 | Nagpal JK, Eur J Clin Invest 2002; 32: 943 | Singh M,
Tumour Biol 2009; 30: 276
Iran Contributing studies: Esmaeili M, Gynecol Obstet Invest 2008; 66: 68 | Ghaffari
SR, Asian Pac J Cancer Prev 2006; 7: 529 | Khodakarami N, Int J Cancer 2012;
131: E156
Israel Contributing studies: Bassal R, J Low Genit Tract Dis 2015; 19: 161 | Laskov I,
Int J Gynecol Cancer 2013; 23: 730
Japan Contributing studies: Azuma Y, Jpn J Clin Oncol 2014 | Ichimura H, Int J Clin
Oncol 2003; 8: 322 | Inoue M, Int J Gynecol Cancer 2006; 16: 1007 | Konno R,
Cancer Sci 2011; 102: 877 | Matsumoto K, Int J Cancer 2011; 128: 2898 | Nagai
Y, Gynecol Oncol 2000; 79: 294 | Nakamura Y, Int J Clin Oncol 2015; 20: 974 |
Nishiwaki M, J Clin Microbiol 2008; 46: 1161 | Niwa K, Oncol Rep 2003; 10:
1437 | Okadome M, J Obstet Gynaecol Res 2014; 40: 561 | Onuki M, Cancer Sci
2009; 100: 1312 | Sasagawa T, Cancer Epidemiol Biomarkers Prev 2001; 10: 45
| Takehara K, Patholog Res Int 2011; 2011: 246936 | Tsuda H, Gynecol Oncol
2003; 91: 476 | Yamasaki K, J Obstet Gynaecol Res 2011; 37: 1666 | Yoshida T,
Cancer 2004; 102: 100
Republic of Korea Contributing studies: Cho NH, Am J Obstet Gynecol 2003; 188: 56 | Hwang TS,
Gynecol Oncol 2003; 90: 51 | Kahng J, Ann Lab Med 2014; 34: 127 | Kang WD,
Int J Gynecol Cancer 2009; 19: 924 | Oh YL, Cytopathology 2001; 12: 75 | Quek
SC, Int J Gynecol Cancer 2013; 23: 148
Kuwait Contributing studies: Al-Awadhi R, Diagn Cytopathol 2013; 41: 107 | Al-Awadhi
R, J Med Virol 2011; 83: 453
Sri Lanka Contributing studies: Karunaratne K, BMC Cancer 2014; 14: 116
Myanmar Contributing studies: Mu-Mu-Shwe, Acta Med Okayama 2014; 68: 79
Malaysia Contributing studies: Quek SC, Int J Gynecol Cancer 2013; 23: 148
Pakistan Contributing studies: Raza SA, Br J Cancer 2010; 102: 1657
Philippines Contributing studies: Quek SC, Int J Gynecol Cancer 2013; 23: 148
Singapore Contributing studies: Quek SC, Int J Gynecol Cancer 2013; 23: 148
Thailand Contributing studies: Chansaenroj J, Asian Pac J Cancer Prev 2010; 11: 117 |
Chansaenroj J, J Med Virol 2014; 86: 601 | Limpaiboon T, Southeast Asian J
Trop Med Public Health 2000; 31: 66 | Sukasem C, J Med Virol 2011; 83: 119 |
Suwannarurk K, Cancer Epidemiol 2009; 33: 56 | Swangvaree SS, Asian Pac J
Cancer Prev 2013; 14: 1023
Turkey Contributing studies: Baser E, Int J Gynaecol Obstet 2014; 125: 275 | Sahiner
F, Mikrobiyol Bul 2012; 46: 624 | Tezcan S, Asian Pac J Cancer Prev 2014; 15:
3997 | Yuce K, Arch Gynecol Obstet 2012; 286: 203
Taiwan Contributing studies: Chao A, Int J Cancer 2008; 122: 2835 | Chao A, Int J
Cancer 2010; 126: 191 | Ho CM, Gynecol Oncol 2005; 99: 615 | Lai HC, Int J
Cancer 2003; 103: 221 | Lin H, Gynecol Oncol 2005; 96: 84 | Yang YY, J
Microbiol Immunol Infect 2004; 37: 282
Viet Nam Contributing studies: Quek SC, Int J Gynecol Cancer 2013; 23: 148
(Continued)
Table 32 Continued
Country Study
Europe
Austria Contributing studies: Rssler L, Wien Klin Wochenschr 2013; 125: 591
Belgium Contributing studies: Arbyn M, Cancer Epidemiol Biomarkers Prev 2009; 18:
321 | Baay MF, Eur J Gynaecol Oncol 2001; 22: 204 | Beerens E, Cytopathology
2005; 16: 199 | Depuydt CE, Br J Cancer 2003; 88: 560
Belarus Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771
Switzerland Contributing studies: Dobec M, J Med Virol 2011; 83: 1370
Czech Republic Contributing studies: Tachezy R, PLoS ONE 2011; 6: e21913
Germany Contributing studies: de Jonge M, Acta Cytol 2013; 57: 591 | Klug SJ, J Med
Virol 2007; 79: 616 | Merkelbach-Bruse S, Diagn Mol Pathol 1999; 8: 32 | Meyer
T, Int J Gynecol Cancer 2001; 11: 198 | Nindl I, Int J Gynecol Pathol 1997; 16:
197 | Nindl I, J Clin Pathol 1999; 52: 17
Denmark Contributing studies: Bonde J, BMC Infect Dis 2014; 14: 413 | Hording U, Eur J
Obstet Gynecol Reprod Biol 1995; 62: 49 | Kirschner B, Acta Obstet Gynecol
Scand 2013; 92: 1032 | Kjaer SK, Int J Cancer 2008; 123: 1864 | Kjr SK,
Cancer Causes Control 2014; 25: 179 | Sebbelov AM, Res Virol 1994; 145: 83 |
Thomsen LT, Int J Cancer 2015; 137: 193
Spain Contributing studies: Bosch FX, Cancer Epidemiol Biomarkers Prev 1993; 2:
415 | Conesa-Zamora P, BMC Infect Dis 2009; 9: 124 | Darwich L, Int J Gynecol
Cancer 2011; 21: 1486 | de Mndez MT, Acta Cytol 2009; 53: 540 | de Oa M, J
Med Virol 2010; 82: 597 | Garca-Sierra N, J Clin Microbiol 2009; 47: 2165 |
Herraez-Hernandez E, J Virol Methods 2013; 193: 9 | Martn P, BMC Infect Dis
2011; 11: 316 | Muoz N, Int J Cancer 1992; 52: 743
France Contributing studies: Monsonego J, Int J STD AIDS 2008; 19: 385 | Prtet JL,
Int J Cancer 2008; 122: 424 | Vaucel E, Arch Gynecol Obstet 2011; 284: 989
United Kingdom Contributing studies: Anderson L, J Med Virol 2013; 85: 295 | Arends MJ, Hum
Pathol 1993; 24: 432 | Cuschieri KS, J Clin Pathol 2004; 57: 68 | Cuzick J, Br J
Cancer 1994; 69: 167 | Cuzick J, J Clin Virol 2014; 60: 44 | Geraets DT, J Clin
Microbiol 2014; 52: 3996 | Herrington CS, Br J Cancer 1995; 71: 206 | Hibbitts
S, Br J Cancer 2008; 99: 1929 | Howell-Jones R, Br J Cancer 2010; 103: 209 |
Jamison J, Cytopathology 2009; 20: 242 | Sargent A, Br J Cancer 2008; 98: 1704
| Southern SA, Diagn Mol Pathol 1998; 7: 114
Greece Contributing studies: Agorastos T, Eur J Obstet Gynecol Reprod Biol 2005; 121:
99 | Argyri E, BMC Infect Dis 2013; 13: 53 | Daponte A, J Clin Virol 2006; 36:
189 | Kroupis C, Epidemiol Infect 2007; 135: 943 | Labropoulou V, Sex Transm
Dis 1997; 24: 469 | Panotopoulou E, J Med Virol 2007; 79: 1898 | Paraskevaidis
E, Gynecol Oncol 2001; 82: 355 | Tsiodras S, Clin Microbiol Infect 2011; 17: 1185
Croatia Contributing studies: Grce M, Anticancer Res 2001; 21: 579 | Grce M, J Clin
Microbiol 2004; 42: 1341
Hungary Contributing studies: Szoke K, J Med Virol 2003; 71: 585
Ireland Contributing studies: Butler D, J Pathol 2000; 192: 502 | Keegan H, J Virol
Methods 2014; 201: 93 | Murphy N, J Clin Pathol 2003; 56: 56 | OLeary JJ, J
Clin Pathol 1998; 51: 576
Iceland Contributing studies: Sigurdsson K, Int J Cancer 2007; 121: 2682
Italy Contributing studies: Agarossi A, J Med Virol 2009; 81: 529 | Capra G, Virus
Res 2008; 133: 195 | Carozzi F, J Clin Virol 2014; 60: 257 | Carozzi FM, Cancer
Epidemiol Biomarkers Prev 2010; 19: 2389 | Gargiulo F, Virus Res 2007; 125:
176 | Giorgi Rossi P, BMC Infect Dis 2010; 10: 214 | Laconi S, Pathologica 2000;
92: 524 | Sandri MT, J Med Virol 2009; 81: 271 | Spinillo A, J Med Virol 2014;
86: 1145 | Tornesello ML, J Med Virol 2006; 78: 1663 | Venturoli S, J Med Virol
2008; 80: 1434 | Zerbini M, J Clin Pathol 2001; 54: 377
Lithuania Contributing studies: Gudleviciene Z, Medicina (Kaunas) 2005; 41: 910 |
Simanaviciene V, J Med Virol 2014
Latvia Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771
(Continued)
Table 32 Continued
Country Study
Netherlands Contributing studies: Bulkmans NW, Int J Cancer 2005; 117: 177 | Cornelissen
MT, Virchows Arch, B, Cell Pathol 1992; 62: 167 | Prinsen CF, BJOG 2007; 114:
951 | Reesink-Peters N, Eur J Obstet Gynecol Reprod Biol 2001; 98: 199 | Tang
N, J Clin Virol 2009; 45 Suppl 1: S25 | van Duin M, Int J Cancer 2003; 105: 577
Norway Contributing studies: Kraus I, Br J Cancer 2004; 90: 1407 | Molden T, Cancer
Epidemiol Biomarkers Prev 2005; 14: 367 | Roberts CC, J Clin Virol 2006; 36:
277 | Sjoeborg KD, Gynecol Oncol 2010; 118: 29
Portugal Contributing studies: Medeiros R, Eur J Cancer Prev 2005; 14: 467 | Nobre RJ,
J Med Virol 2010; 82: 1024 | Pista A, Clin Microbiol Infect 2011; 17: 941 | Pista
A, Int J Gynecol Cancer 2013; 23: 500
Romania Contributing studies: Anton G, APMIS 2011; 119: 1 | Ursu RG, Virol J 2011; 8:
558
Russian Federation Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771
Slovenia Contributing studies: Kovanda A, Acta Dermatovenerol Alp Pannonica Adriat
2009; 18: 47
Sweden Contributing studies: Andersson S, Br J Cancer 2005; 92: 2195 | Kalantari M,
Hum Pathol 1997; 28: 899 | Zehbe I, Virchows Arch 1996; 428: 151
Oceania
Australia Contributing studies: Brestovac B, J Med Virol 2005; 76: 106 | Callegari ET,
Vaccine 2014; 32: 4082 | Garland SM, BMC Med 2011; 9: 104 | Stevens MP, Int
J Gynecol Cancer 2006; 16: 1017 | Stevens MP, J Med Virol 2009; 81: 1283
Fiji Contributing studies: Tabrizi SN, Sex Health 2011; 8: 338
New Zealand Contributing studies: Kang YJ, BMC Infect Dis 2015; 15: 365
HPV type distribution for cervical low grade squamous intraepithelial lesions
General sources Based on meta-analysis performed by IARCs Infections and Cancer
Epidemiology Group up to November 2011, the ICO HPV Information Centre has
updated data until June 2015. Reference publications: 1) Guan P, Int J Cancer
2012;131:2349 2) Clifford GM, Cancer Epidemiol Biomarkers Prev 2005;14:1157
Africa
Cte dIvoire Contributing studies: La Ruche G, Int J Cancer 1998; 76: 480
Cameroon Contributing studies: Untiet S, Int J Cancer 2014; 135: 1911
DR Congo Contributing studies: Hovland S, Br J Cancer 2010; 102: 957
Algeria Contributing studies: Hammouda D, Int J Cancer 2011; 128: 2224
Ethiopia Contributing studies: Abate E, J Med Virol 2013; 85: 282
Guinea Contributing studies: Keita N, Br J Cancer 2009; 101: 202
Kenya Contributing studies: De Vuyst H, Cancer Causes Control 2010; 21: 2309 | De
Vuyst H, Int J Cancer 2012; 131: 949 | De Vuyst H, Sex Transm Dis 2003; 30:
137
Morocco Contributing studies: Alhamany Z, J Infect Dev Ctries 2010; 4: 732
Nigeria Contributing studies: Gage JC, Int J Cancer 2012; 131: 2903 | Thomas JO, Br J
Cancer 2004; 90: 638
Senegal Contributing studies: Chabaud M, J Med Virol 1996; 49: 259 | Xi LF, Int J
Cancer 2003; 103: 803
South Africa Contributing studies: Allan B, J Clin Microbiol 2008; 46: 740 | van Aardt MC,
Personal communication Unpublished
Zimbabwe Contributing studies: Sawaya GF, Obstet Gynecol 2008; 112: 990
Americas
Argentina Contributing studies: Abba MC, Rev Argent Microbiol 2003; 35: 74 | Chouhy D,
Int J Mol Med 2006; 18: 995 | Deluca GD, Rev Inst Med Trop Sao Paulo 2004;
46: 9 | Eiguchi K, J Low Genit Tract Dis 2008; 12: 262 | Tonon SA, Infect Dis
Obstet Gynecol 1999; 7: 237 | Venezuela RF, Rev Inst Med Trop Sao Paulo 2012;
54: 11
Belize Contributing studies: Cathro HP, Hum Pathol 2009; 40: 942
(Continued)
Table 32 Continued
Country Study
Brazil Contributing studies: Carestiato FN, Rev Soc Bras Med Trop 2006; 39: 428 |
Fernandes JV, Int J Gynaecol Obstet 2009; 105: 21 | Franco E, Rev Panam
Salud Publica 1999; 6: 223 | Freitas TP, Rev Inst Med Trop Sao Paulo 2007; 49:
297 | Krambeck WM, Clin Exp Obstet Gynecol 2008; 35: 175 | Lorenzato F, Int
J Gynecol Cancer 2000; 10: 143 | Pitta DR, Rev Bras Ginecol Obstet 2010; 32:
315 | Resende LS, BMC Infect Dis 2014; 14: 214 | Ribeiro AA, Int J Gynecol
Pathol 2011; 30: 288 | Tomita LY, Int J Cancer 2010; 126: 703
Canada Contributing studies: Antonishyn NA, Arch Pathol Lab Med 2008; 132: 54 |
Coutle F, J Med Virol 2011; 83: 1034 | Jiang Y, J Infect Public Health 2011; 4:
219 | Koushik A, Cancer Detect Prev 2005; 29: 307 | Moore RA, Cancer Causes
Control 2009; 20: 1387 | Richardson H, Cancer Epidemiol Biomarkers Prev
2003; 12: 485 | Sellors JW, CMAJ 2000; 163: 503 | Sellors JW, CMAJ 2000; 163:
513 | Tran-Thanh D, Am J Obstet Gynecol 2003; 188: 129
Chile Contributing studies: Ili CG, J Med Virol 2011; 83: 833 | Lpez M J, Rev Med
Chil 2010; 138: 1343
Colombia Contributing studies: Del Ro-Ospina L, BMC Cancer 2015; 15: 100 | Garca
DA, Open Virol J 2011; 5: 70 | Molano M, Br J Cancer 2002; 87: 1417
Cuba Contributing studies: Soto Y, Sex Transm Dis 2007; 34: 974
Ecuador Contributing studies: Tornesello ML, J Med Virol 2008; 80: 1959
Honduras Contributing studies: Ferreira M, Mod Pathol 2008; 21: 968
Jamaica Contributing studies: Rattray C, J Infect Dis 1996; 173: 718 | Strickler HD, J
Med Virol 1999; 59: 60
Mexico Contributing studies: Carrillo A, Salud Publica Mex 2004; 46: 7 | Giuliano AR,
Cancer Epidemiol Biomarkers Prev 2001; 10: 1129 | Gonzlez-Losa Mdel R, J
Clin Virol 2004; 29: 202 | Illades-Aguiar B, Gynecol Oncol 2010; 117: 291 |
Pia-Snchez P, Int J Gynecol Cancer 2006; 16: 1041 | Torroella-Kouri M,
Gynecol Oncol 1998; 70: 115 | Velzquez-Mrquez N, Int J Infect Dis 2009; 13:
690
Nicaragua Contributing studies: Hindryckx P, Sex Transm Infect 2006; 82: 334
Peru Contributing studies: Martorell M, Genet Mol Res 2012; 11: 2099
Paraguay Contributing studies: Mendoza LP, J Med Virol 2011; 83: 1351 | Tonon SA,
Infect Dis Obstet Gynecol 1999; 7: 237
Uruguay Contributing studies: Ramas V, J Med Virol 2013; 85: 845
USA Contributing studies: Adam E, Am J Obstet Gynecol 2000; 182: 257 | Bell MC,
Gynecol Oncol 2007; 107: 236 | Brown DR, Sex Transm Dis 2002; 29: 763 |
Castle PE, Cancer Epidemiol Biomarkers Prev 2011; 20: 946 | Einstein MH, Int
J Cancer 2007; 120: 55 | Evans MF, Cancer 2006; 106: 1054 | Evans MF, Mod
Pathol 2002; 15: 1339 | Giuliano AR, Cancer Epidemiol Biomarkers Prev 2001;
10: 1129 | Guo M, Mod Pathol 2007; 20: 256 | Hu L, Mod Pathol 2005; 18: 267 |
Jarboe EA, Hum Pathol 2004; 35: 396 | Kong CS, Am J Surg Pathol 2007; 31: 33
| Kulasingam SL, JAMA 2002; 288: 1749 | Lee SH, Int J Gynaecol Obstet 2009;
105: 210 | Liaw KL, J Natl Cancer Inst 1999; 91: 954 | Moscicki AB, Obstet
Gynecol 2008; 112: 1335 | Park K, Int J Gynecol Pathol 2007; 26: 457 | Schiff
M, Am J Epidemiol 2000; 152: 716 | Stoler MH, Am J Clin Pathol 2011; 135: 468
| Swan DC, J Clin Microbiol 1999; 37: 1030 | Tortolero-Luna G, Cad Saude
Publica 1998; 14 Suppl 3: 149 | Vidal AC, Cancer Causes Control 2014; 25: 1055
| Voss JS, Anal Quant Cytol Histol 2009; 31: 208 | Wentzensen N, Int J Cancer
2009; 124: 964 | Wheeler CM, J Infect Dis 2006; 194: 1291 | Wheeler CM, J
Natl Cancer Inst 2009; 101: 475 | Zuna RE, Mod Pathol 2007; 20: 167
Venezuela Contributing studies: Correnti M, Gynecol Oncol 2011; 121: 527
Asia
Bangladesh Contributing studies: Banik U, Cytojournal 2013; 10: 14
(Continued)
Table 32 Continued
Country Study
China Contributing studies: Chan PK, Int J Cancer 2006; 118: 243 | Chan PK, Int J
Cancer 2012; 131: 692 | Chan PK, J Med Virol 1999; 59: 232 | Ding X, J Med
Virol 2014; 86: 1937 | Guo J, Scand J Infect Dis 2010; 42: 72 | Hong D, Int J
Gynecol Cancer 2008; 18: 104 | Jin Q, Chin Med J 2010; 123: 2004 | Li H, Eur J
Obstet Gynecol Reprod Biol 2013; 170: 202 | Li J, J Clin Microbiol 2012; 50:
1079 | Liu SS, Tumour Biol 2008; 29: 105 | Liu X, Int J Gynecol Cancer 2010;
20: 147 | Sun B, Arch Virol 2014; 159: 1027 | Tao PP, Zhonghua Fu Chan Ke Za
Zhi 2006; 41: 43 | Wu D, Eur J Obstet Gynecol Reprod Biol 2010; 151: 86 | Wu
EQ, Cancer Causes Control 2013; 24: 795 | Yuan X, Arch Gynecol Obstet 2011;
283: 1385 | Zhang R, Cancer Epidemiol 2013; 37: 939 | Zhao FH, Int J Cancer
2014; 135: 2604 | Zhao Y, Pathol Int 2008; 58: 643
India Contributing studies: Berlin Grace VM, Indian J Cancer 2009; 46: 203 |
Franceschi S, Br J Cancer 2005; 92: 601 | Nagpal JK, Eur J Clin Invest 2002; 32:
943 | Nair P, Pathol Oncol Res 1999; 5: 95 | Singh M, Tumour Biol 2009; 30: 276
Iran Contributing studies: Esmaeili M, Gynecol Obstet Invest 2008; 66: 68 | Ghaffari
SR, Asian Pac J Cancer Prev 2006; 7: 529 | Khodakarami N, Int J Cancer 2012;
131: E156
Japan Contributing studies: Inoue M, Int J Gynecol Cancer 2006; 16: 1007 | Konno R,
Cancer Sci 2011; 102: 877 | Matsumoto K, Int J Cancer 2011; 128: 2898 |
Nishiwaki M, J Clin Microbiol 2008; 46: 1161 | Onuki M, Cancer Sci 2009; 100:
1312 | Saito J, Jap J Obstet Gynecol Pract 2001; 50: 871 | Sasagawa T, Cancer
Epidemiol Biomarkers Prev 2001; 10: 45 | Takehara K, Patholog Res Int 2011;
2011: 246936 | Tsuda H, Gynecol Oncol 2003; 91: 476 | Yamasaki K, J Obstet
Gynaecol Res 2011; 37: 1666 | Yoshida T, Cancer 2004; 102: 100
Republic of Korea Contributing studies: An HJ, Cancer 2003; 97: 1672 | Cho NH, Am J Obstet
Gynecol 2003; 188: 56 | Hwang TS, Gynecol Oncol 2003; 90: 51 | Kang WD, Int
J Gynecol Cancer 2009; 19: 924 | Lee HS, Int J Gynecol Cancer 2007; 17: 497 |
Oh YL, Cytopathology 2001; 12: 75
Kuwait Contributing studies: Al-Awadhi R, Diagn Cytopathol 2013; 41: 107 | Al-Awadhi
R, J Med Virol 2011; 83: 453
Myanmar Contributing studies: Mu-Mu-Shwe, Acta Med Okayama 2014; 68: 79
Malaysia Contributing studies: Sharifah NA, Asian Pac J Cancer Prev 2009; 10: 303
Pakistan Contributing studies: Raza SA, Br J Cancer 2010; 102: 1657
Thailand Contributing studies: Bhattarakosol P, J Med Assoc Thai 2002; 85 Suppl 1: S360
| Chaiwongkot A, Asian Pac J Cancer Prev 2007; 8: 279 | Chansaenroj J, Asian
Pac J Cancer Prev 2010; 11: 117 | Chansaenroj J, J Med Virol 2014; 86: 601 |
Ekalaksananan T, J Obstet Gynaecol Res 2001; 27: 117 | Suwannarurk K,
Cancer Epidemiol 2009; 33: 56
Turkey Contributing studies: Ergnay K, Mikrobiyol Bul 2008; 42: 273 | Ozgul N, J
Obstet Gynaecol Res 2008; 34: 865 | Sahiner F, Mikrobiyol Bul 2012; 46: 624 |
Tezcan S, Asian Pac J Cancer Prev 2014; 15: 3997 | Yuce K, Arch Gynecol
Obstet 2012; 286: 203
Taiwan Contributing studies: Chao A, Int J Cancer 2008; 122: 2835 | Ding DC, Eur J
Obstet Gynecol Reprod Biol 2008; 140: 245 | Huang YK, Br J Cancer 2008; 98:
863
Europe
Belgium Contributing studies: Arbyn M, Cancer Epidemiol Biomarkers Prev 2009; 18:
321 | Baay MF, Eur J Gynaecol Oncol 2001; 22: 204 | Beerens E, Cytopathology
2005; 16: 199 | Depuydt CE, Br J Cancer 2003; 88: 560 | Weyn C, Cancer
Epidemiol 2013; 37: 457
Belarus Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771
Switzerland Contributing studies: Dobec M, J Med Virol 2011; 83: 1370
Czech Republic Contributing studies: Tachezy R, PLoS ONE 2011; 6: e21913
Germany Contributing studies: de Jonge M, Acta Cytol 2013; 57: 591 | Klug SJ, J Med
Virol 2007; 79: 616 | Merkelbach-Bruse S, Diagn Mol Pathol 1999; 8: 32 | Meyer
T, Int J Gynecol Cancer 2001; 11: 198 | Nindl I, J Clin Pathol 1999; 52: 17
(Continued)
Table 32 Continued
Country Study
Denmark Contributing studies: Hording U, Eur J Obstet Gynecol Reprod Biol 1995; 62: 49
| Kjaer SK, Int J Cancer 2008; 123: 1864 | Kjr SK, Cancer Causes Control
2014; 25: 179
Spain Contributing studies: Conesa-Zamora P, BMC Infect Dis 2009; 9: 124 | de
Mndez MT, Acta Cytol 2009; 53: 540 | de Oa M, J Med Virol 2010; 82: 597 |
Domnech-Peris A, Gynecol Obstet Invest 2010; 70: 113 | Garca-Sierra N, J
Clin Microbiol 2009; 47: 2165 | Herraez-Hernandez E, J Virol Methods 2013;
193: 9 | Martn P, BMC Infect Dis 2011; 11: 316
France Contributing studies: Bergeron C, Am J Surg Pathol 1992; 16: 641 | Humbey O,
Eur J Obstet Gynecol Reprod Biol 2002; 103: 60 | Monsonego J, Int J STD AIDS
2008; 19: 385 | Prtet JL, Gynecol Oncol 2008; 110: 179 | Vaucel E, Arch
Gynecol Obstet 2011; 284: 989
United Kingdom Contributing studies: Anderson L, J Med Virol 2013; 85: 295 | Arends MJ, Hum
Pathol 1993; 24: 432 | Cuschieri KS, J Clin Pathol 2004; 57: 68 | Cuzick J, Br J
Cancer 1994; 69: 167 | Cuzick J, Br J Cancer 1999; 81: 554 | Giannoudis A, Int
J Cancer 1999; 83: 66 | Hibbitts S, Br J Cancer 2008; 99: 1929 | Howell-Jones
R, Br J Cancer 2010; 103: 209 | Jamison J, Cytopathology 2009; 20: 242 |
Sargent A, Br J Cancer 2008; 98: 1704 | Southern SA, Hum Pathol 2001; 32:
1351 | Woo YL, Int J Cancer 2010; 126: 133
Greece Contributing studies: Adamopoulou M, Anticancer Res 2009; 29: 3401 | Argyri
E, BMC Infect Dis 2013; 13: 53 | Kroupis C, Epidemiol Infect 2007; 135: 943 |
Labropoulou V, Sex Transm Dis 1997; 24: 469 | Mammas IN, Oncol Rep 2008;
20: 141 | Panotopoulou E, J Med Virol 2007; 79: 1898 | Tsiodras S, Clin
Microbiol Infect 2011; 17: 1185
Croatia Contributing studies: Grce M, Anticancer Res 2001; 21: 579 | Grce M, Eur J
Epidemiol 1997; 13: 645 | Grce M, J Clin Microbiol 2004; 42: 1341
Ireland Contributing studies: Butler D, J Pathol 2000; 192: 502 | Keegan H, J Virol
Methods 2014; 201: 93 | Murphy N, J Clin Pathol 2003; 56: 56
Italy Contributing studies: Agarossi A, J Med Virol 2009; 81: 529 | Agodi A, Int J
Gynecol Cancer 2009; 19: 1094 | Astori G, Virus Res 1997; 50: 57 | Capra G,
Virus Res 2008; 133: 195 | Chironna M, J Prev Med Hyg 2010; 51: 139 |
Gargiulo F, Virus Res 2007; 125: 176 | Giorgi Rossi P, BMC Infect Dis 2010; 10:
214 | Laconi S, Pathologica 2000; 92: 524 | Menegazzi P, Infect Dis Obstet
Gynecol 2009; 2009: 198425 | Sandri MT, J Med Virol 2009; 81: 271 | Spinillo A,
Gynecol Oncol 2009; 113: 115 | Spinillo A, J Med Virol 2014; 86: 1145 |
Tornesello ML, J Med Virol 2006; 78: 1663 | Venturoli S, J Clin Virol 2002; 25:
177 | Venturoli S, J Med Virol 2008; 80: 1434 | Voglino G, Pathologica 2000; 92:
516 | Zerbini M, J Clin Pathol 2001; 54: 377
Lithuania Contributing studies: Gudleviciene Z, Medicina (Kaunas) 2005; 41: 910
Latvia Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771
Netherlands Contributing studies: Bollen LJ, Am J Obstet Gynecol 1997; 177: 548 | Prinsen
CF, BJOG 2007; 114: 951 | Reesink-Peters N, Eur J Obstet Gynecol Reprod Biol
2001; 98: 199
Norway Contributing studies: Molden T, Cancer Epidemiol Biomarkers Prev 2005; 14:
367 | Roberts CC, J Clin Virol 2006; 36: 277
Portugal Contributing studies: Medeiros R, Eur J Cancer Prev 2005; 14: 467 | Nobre RJ,
J Med Virol 2010; 82: 1024
Romania Contributing studies: Anton G, APMIS 2011; 119: 1 | Ursu RG, Virol J 2011; 8:
558
Russian Federation Contributing studies: Kulmala SM, J Med Virol 2007; 79: 771
Sweden Contributing studies: Andersson S, Br J Cancer 2005; 92: 2195 |
Brismar-Wendel S, Br J Cancer 2009; 101: 511 | Kalantari M, Hum Pathol 1997;
28: 899 | Sderlund-Strand A, Am J Obstet Gynecol 2011; 205: 145.e1 | Zehbe I,
Virchows Arch 1996; 428: 151
(Continued)
Table 32 Continued
Country Study
Oceania
Australia Contributing studies: Brestovac B, J Med Virol 2005; 76: 106 | Garland SM,
BMC Med 2011; 9: 104 | Stevens MP, J Med Virol 2009; 81: 1283
HPV type distribution for invasive anal cancer
General sources Based on systematic reviews (up to 2008) performed by ICO for the IARC
Monograph on the Evaluation of Carcinogenic Risks to Humans volume 100B
and IARCs Infections and Cancer Epidemiology Group. The ICO HPV
Information Centre has updated data until June 2015. Reference publications: 1)
Bouvard V, Lancet Oncol 2009;10:321 2) De Vuyst H, Int J Cancer 2009;124:1626
Africa
Mali Alemany L, Int J Cancer 2015; 136: 98
Nigeria Alemany L, Int J Cancer 2015; 136: 98
Senegal Alemany L, Int J Cancer 2015; 136: 98
Americas
Canada Ouhoummane N, Cancer Epidemiol 2013; 37: 807
Chile Alemany L, Int J Cancer 2015; 136: 98
Colombia Alemany L, Int J Cancer 2015; 136: 98
Ecuador Alemany L, Int J Cancer 2015; 136: 98
Guatemala Alemany L, Int J Cancer 2015; 136: 98
Honduras Alemany L, Int J Cancer 2015; 136: 98
Mexico Alemany L, Int J Cancer 2015; 136: 98
Paraguay Alemany L, Int J Cancer 2015; 136: 98
USA Alemany L, Int J Cancer 2015; 136: 98 | Daling JR, Cancer 2004; 101: 270 |
Noffsinger AE, Mod Pathol 1995; 8: 509 | Palefsky JM, Cancer Res 1991; 51:
1014 | Shroyer KR, Am J Clin Pathol 1995; 104: 299 | Zaki SR, Am J Pathol
1992; 140: 1345
Asia
Bangladesh Alemany L, Int J Cancer 2015; 136: 98
China Lai MD, World J Gastroenterol 1998; 4: 298
India Alemany L, Int J Cancer 2015; 136: 98
Republic of Korea Alemany L, Int J Cancer 2015; 136: 98 | Yhim HY, Int J Cancer 2011; 129: 1752
| Youk EG, Dis Colon Rectum 2001; 44: 236
Europe
Bosnia & Herzegovina Alemany L, Int J Cancer 2015; 136: 98
Switzerland Poletti PA, Int J Colorectal Dis 1998; 13: 108
Czech Republic Alemany L, Int J Cancer 2015; 136: 98 | Tachezy R, PLoS ONE 2011; 6: e21913
Germany Alemany L, Int J Cancer 2015; 136: 98 | Kreuter A, Br J Dermatol 2010; 162:
1269 | Rdel F, Int J Cancer 2015; 136: 278 | Varnai AD, Int J Colorectal Dis
2006; 21: 135
Denmark Frisch M, N Engl J Med 1997; 337: 1350 | Serup-Hansen E, J Clin Oncol 2014;
32: 1812
Spain Alemany L, Int J Cancer 2015; 136: 98
France Abramowitz L, Int J Cancer 2011; 129: 433 | Alemany L, Int J Cancer 2015;
136: 98 | Valmary-Degano S, Hum Pathol 2013; 44: 992 | Vincent-Salomon A,
Mod Pathol 1996; 9: 614
United Kingdom Alemany L, Int J Cancer 2015; 136: 98 | Baricevic I, Eur J Cancer 2015; 51: 776
| Crook T, Oncogene 1991; 6: 1251 | Ogunbiyi OA, J Clin Pathol 1993; 46: 507
Italy Indinnimeo M, J Exp Clin Cancer Res 1999; 18: 47
Poland Alemany L, Int J Cancer 2015; 136: 98
Portugal Alemany L, Int J Cancer 2015; 136: 98
Slovenia Alemany L, Int J Cancer 2015; 136: 98
Sweden Frisch M, N Engl J Med 1997; 337: 1350 | Laytragoon-Lewin N, Anticancer Res
2007; 27: 4473
(Continued)
Table 32 Continued
Country Study
Oceania
Australia Hillman RJ, Int J Cancer 2014; 135: 996
HPV type distribution for anal intraepithelial neoplasia (AIN)
General sources Based on systematic reviews (up to 2008) performed by ICO for the IARC
Monograph on the Evaluation of Carcinogenic Risks to Humans volume 100B
and IARCs Infections and Cancer Epidemiology Group. The ICO HPV
Information Centre has updated data until June 2015. Reference publications: 1)
Bouvard V, Lancet Oncol 2009;10:321 2) De Vuyst H, Int J Cancer 2009;124:1626
Americas
Canada Gohy L, J Acquir Immune Defic Syndr 2008; 49: 32 | Salit IE, Cancer Epidemiol
Biomarkers Prev 2009; 18: 1986
Chile Alemany L, Int J Cancer 2015; 136: 98
Colombia Alemany L, Int J Cancer 2015; 136: 98
Ecuador Alemany L, Int J Cancer 2015; 136: 98
Guatemala Alemany L, Int J Cancer 2015; 136: 98
Honduras Alemany L, Int J Cancer 2015; 136: 98
Mexico Alemany L, Int J Cancer 2015; 136: 98
Paraguay Alemany L, Int J Cancer 2015; 136: 98
USA Sahasrabuddhe VV, J Infect Dis 2013; 207: 392
Asia
Thailand Phanuphak N, PLoS ONE 2013; 8: e78291
Europe
Bosnia & Herzegovina Alemany L, Int J Cancer 2015; 136: 98
Czech Republic Alemany L, Int J Cancer 2015; 136: 98
Germany Alemany L, Int J Cancer 2015; 136: 98 | Hampl M, J Cancer Res Clin Oncol
2007; 133: 235 | Hampl M, Obstet Gynecol 2006; 108: 1361 | Kreuter A, Br J
Dermatol 2010; 162: 1269 | Silling S, J Clin Virol 2012; 53: 325 | Varnai AD, Int
J Colorectal Dis 2006; 21: 135 | Wieland U, Arch Dermatol 2006; 142: 1438
Spain Alemany L, Int J Cancer 2015; 136: 98 | Caadas MP, J Clin Virol 2010; 48: 198
| Garca-Espinosa B, Diagn Pathol 2013; 8: 204 | Sirera G, AIDS 2013; 27: 951
| Torres M, J Clin Microbiol 2013; 51: 3512
France Alemany L, Int J Cancer 2015; 136: 98
United Kingdom Alemany L, Int J Cancer 2015; 136: 98 | Fox PA, Sex Transm Infect 2005; 81:
142 | Ogunbiyi OA, J Clin Pathol 1993; 46: 507 | Ogunbiyi OA, Obstet Gynecol
1994; 83: 212
Italy Tanzi E, Vaccine 2009; 27 Suppl 1: A17
Netherlands Richel O, J Infect Dis 2014; 210: 111
Poland Alemany L, Int J Cancer 2015; 136: 98
Portugal Alemany L, Int J Cancer 2015; 136: 98
Slovenia Alemany L, Int J Cancer 2015; 136: 98
Oceania
Australia Hillman RJ, Sex Health 2012; 9: 574
HPV type distribution for invasive vulvar cancer
General sources Based on systematic reviews (up to 2008) performed by ICO for the IARC
Monograph on the Evaluation of Carcinogenic Risks to Humans volume 100B
and IARCs Infections and Cancer Epidemiology Group. The ICO HPV
Information Centre has updated data until June 2015. Reference publications: 1)
Bouvard V, Lancet Oncol 2009;10:321 2) De Vuyst H, Int J Cancer 2009;124:1626
Africa
Mali de Sanjos S, Eur J Cancer 2013; 49: 3450
Mozambique de Sanjos S, Eur J Cancer 2013; 49: 3450
Nigeria de Sanjos S, Eur J Cancer 2013; 49: 3450
Senegal de Sanjos S, Eur J Cancer 2013; 49: 3450
(Continued)
Table 32 Continued
Country Study
Americas
Argentina de Sanjos S, Eur J Cancer 2013; 49: 3450
Brazil de Sanjos S, Eur J Cancer 2013; 49: 3450 | Pinto AP, Gynecol Oncol 1999; 74:
61
Canada Al-Ghamdi A, Gynecol Oncol 2002; 84: 94
Chile de Sanjos S, Eur J Cancer 2013; 49: 3450
Colombia de Sanjos S, Eur J Cancer 2013; 49: 3450
Ecuador de Sanjos S, Eur J Cancer 2013; 49: 3450
Guatemala de Sanjos S, Eur J Cancer 2013; 49: 3450
Honduras de Sanjos S, Eur J Cancer 2013; 49: 3450
Mexico de Sanjos S, Eur J Cancer 2013; 49: 3450
Paraguay de Sanjos S, Eur J Cancer 2013; 49: 3450
Uruguay de Sanjos S, Eur J Cancer 2013; 49: 3450
USA Bloss JD, Hum Pathol 1991; 22: 711 | Carter JJ, Cancer Res 2001; 61: 1934 | de
Sanjos S, Eur J Cancer 2013; 49: 3450 | Gargano JW, J Low Genit Tract Dis
2012; 16: 471 | Kim YT, Hum Pathol 1996; 27: 389 | Lee YY, Oncogene 1994; 9:
1655 | Madeleine MM, J Natl Cancer Inst 1997; 89: 1516 | Monk BJ, Obstet
Gynecol 1995; 85: 709 | Nuovo GJ, Gynecol Oncol 1991; 43: 275 | Pinto AP, Am
J Pathol 1999; 154: 1009 | Riethdorf S, Hum Pathol 2004; 35: 1477 | Sagerman
PM, Gynecol Oncol 1996; 61: 328 | Sutton BC, Mod Pathol 2008; 21: 345 | Tate
JE, Gynecol Oncol 1994; 53: 78
Venezuela de Sanjos S, Eur J Cancer 2013; 49: 3450
Asia
Bangladesh de Sanjos S, Eur J Cancer 2013; 49: 3450
China Gao X, Dermatol Surg 1997; 23: 1025 | Guo L, Zhonghua Fu Chan Ke Za Zhi
1996; 31: 551 | Ngan HY, Eur J Cancer 1999; 35: 481
India de Sanjos S, Eur J Cancer 2013; 49: 3450
Israel de Sanjos S, Eur J Cancer 2013; 49: 3450
Japan Koyamatsu Y, Gynecol Oncol 2003; 90: 547 | Nagano H, J Obstet Gynaecol Res
1996; 22: 1 | Osakabe M, Pathol Int 2007; 57: 322
Republic of Korea de Sanjos S, Eur J Cancer 2013; 49: 3450
Kuwait de Sanjos S, Eur J Cancer 2013; 49: 3450
Lebanon de Sanjos S, Eur J Cancer 2013; 49: 3450
Philippines de Sanjos S, Eur J Cancer 2013; 49: 3450
Thailand Ngamkham J, Asian Pac J Cancer Prev 2013; 14: 2355
Turkey de Sanjos S, Eur J Cancer 2013; 49: 3450
Taiwan de Sanjos S, Eur J Cancer 2013; 49: 3450
Europe
Austria de Sanjos S, Eur J Cancer 2013; 49: 3450
Bosnia & Herzegovina de Sanjos S, Eur J Cancer 2013; 49: 3450
Belarus de Sanjos S, Eur J Cancer 2013; 49: 3450
Czech Republic de Sanjos S, Eur J Cancer 2013; 49: 3450 | Skapa P, Am J Surg Pathol 2007;
31: 1834 | Tachezy R, PLoS ONE 2011; 6: e21913
Germany Choschzick M, Int J Gynecol Pathol 2011; 30: 497 | de Sanjos S, Eur J Cancer
2013; 49: 3450 | Hampl M, Gynecol Oncol 2008; 109: 340 | Hampl M, Obstet
Gynecol 2006; 108: 1361 | Milde-Langosch K, Int J Cancer 1995; 63: 639 |
Reuschenbach M, J Low Genit Tract Dis 2013; 17: 289 | Riethdorf S, Hum
Pathol 2004; 35: 1477
Denmark Bryndorf T, Cytogenet Genome Res 2004; 106: 43 | Hrding U, Gynecol Oncol
1991; 42: 22 | Hrding U, Gynecol Oncol 1994; 52: 241 | Hrding U, Int J
Cancer 1993; 55: 394 | Madsen BS, Int J Cancer 2008; 122: 2827
Spain Alonso I, Gynecol Oncol 2011; 122: 509 | de Sanjos S, Eur J Cancer 2013; 49:
3450 | Guerrero D, Int J Cancer 2011; 128: 2853 | Lerma E, Int J Gynecol
Pathol 1999; 18: 191 | Santos M, Am J Surg Pathol 2006; 30: 1347
(Continued)
Table 32 Continued
Country Study
Finland Iwasawa A, Obstet Gynecol 1997; 89: 81
France de Sanjos S, Eur J Cancer 2013; 49: 3450
United Kingdom Abdel-Hady ES, Cancer Res 2001; 61: 192 | de Sanjos S, Eur J Cancer 2013; 49:
3450 | Gasco M, Oncogene 2002; 21: 1876 | Ogunbiyi OA, Obstet Gynecol 1994;
83: 212
Greece de Sanjos S, Eur J Cancer 2013; 49: 3450
Italy Bonvicini F, J Med Virol 2005; 77: 102 | de Sanjos S, Eur J Cancer 2013; 49:
3450 | Della Torre G, Diagn Mol Pathol 1992; 1: 25 | Pilotti S, Diagn Mol Pathol
1995; 4: 239
Netherlands Ansink AC, Gynecol Oncol 1994; 52: 180 | Kagie MJ, Gynecol Oncol 1997; 67:
178 | Trietsch MD, Br J Cancer 2013; 109: 2259 | van de Nieuwenhof HP,
Cancer Epidemiol Biomarkers Prev 2009; 18: 2061 | van der Avoort IA, Int J
Gynecol Pathol 2006; 25: 22
Poland Bujko M, Acta Obstet Gynecol Scand 2012; 91: 391 | de Sanjos S, Eur J Cancer
2013; 49: 3450 | Kowalewska M, Int J Gynecol Cancer 2010; 20: 434 | Liss J,
Ginekol Pol 1998; 69: 330
Portugal de Sanjos S, Eur J Cancer 2013; 49: 3450
Sweden Larsson GL, Int J Gynecol Cancer 2012; 22: 1413 | Lindell G, Gynecol Oncol
2010; 117: 312
Oceania
Australia Allen DG, Br J Cancer 2002; 86: 924 | de Sanjos S, Eur J Cancer 2013; 49:
3450 | Tan SE, Sex Health 2013; 10: 18
New Zealand de Sanjos S, Eur J Cancer 2013; 49: 3450
HPV type distribution for vulvar intraepithelial neoplasia (VIN)
General sources Based on systematic reviews (up to 2008) performed by ICO for the IARC
Monograph on the Evaluation of Carcinogenic Risks to Humans volume 100B
and IARCs Infections and Cancer Epidemiology Group. The ICO HPV
Information Centre has updated data until June 2015. Reference publications: 1)
Bouvard V, Lancet Oncol 2009;10:321 2) De Vuyst H, Int J Cancer 2009;124:1626
Americas
Argentina de Sanjos S, Eur J Cancer 2013; 49: 3450
Brazil de Sanjos S, Eur J Cancer 2013; 49: 3450
Chile de Sanjos S, Eur J Cancer 2013; 49: 3450
Colombia de Sanjos S, Eur J Cancer 2013; 49: 3450
Ecuador de Sanjos S, Eur J Cancer 2013; 49: 3450
Guatemala de Sanjos S, Eur J Cancer 2013; 49: 3450
Honduras de Sanjos S, Eur J Cancer 2013; 49: 3450
Mexico de Sanjos S, Eur J Cancer 2013; 49: 3450
Paraguay de Sanjos S, Eur J Cancer 2013; 49: 3450
Uruguay de Sanjos S, Eur J Cancer 2013; 49: 3450
USA Gargano JW, J Low Genit Tract Dis 2012; 16: 471 | Madeleine MM, J Natl
Cancer Inst 1997; 89: 1516 | Riethdorf S, Hum Pathol 2004; 35: 1477 | Srodon
M, Am J Surg Pathol 2006; 30: 1513
Venezuela de Sanjos S, Eur J Cancer 2013; 49: 3450
Asia
Bangladesh de Sanjos S, Eur J Cancer 2013; 49: 3450
India de Sanjos S, Eur J Cancer 2013; 49: 3450
Israel de Sanjos S, Eur J Cancer 2013; 49: 3450
Republic of Korea de Sanjos S, Eur J Cancer 2013; 49: 3450
Kuwait de Sanjos S, Eur J Cancer 2013; 49: 3450
Lebanon de Sanjos S, Eur J Cancer 2013; 49: 3450
Philippines de Sanjos S, Eur J Cancer 2013; 49: 3450
Turkey de Sanjos S, Eur J Cancer 2013; 49: 3450
Taiwan de Sanjos S, Eur J Cancer 2013; 49: 3450
(Continued)
Table 32 Continued
Country Study
Europe
Austria de Sanjos S, Eur J Cancer 2013; 49: 3450
Bosnia & Herzegovina de Sanjos S, Eur J Cancer 2013; 49: 3450
Belarus de Sanjos S, Eur J Cancer 2013; 49: 3450
Czech Republic de Sanjos S, Eur J Cancer 2013; 49: 3450 | Skapa P, Am J Surg Pathol 2007;
31: 1834 | Tachezy R, PLoS ONE 2011; 6: e21913
Germany de Sanjos S, Eur J Cancer 2013; 49: 3450 | Hampl M, Obstet Gynecol 2006;
108: 1361 | Hillemanns P, Gynecol Oncol 2006; 100: 276 | Riethdorf S, Hum
Pathol 2004; 35: 1477
Denmark Hrding U, Gynecol Oncol 1991; 42: 22 | Junge J, APMIS 1995; 103: 501
Spain de Sanjos S, Eur J Cancer 2013; 49: 3450 | Lerma E, Int J Gynecol Pathol
1999; 18: 191
France de Sanjos S, Eur J Cancer 2013; 49: 3450
United Kingdom Abdel-Hady ES, Cancer Res 2001; 61: 192 | Baldwin PJ, Clin Cancer Res 2003;
9: 5205 | Baldwin SB, J Infect Dis 2003; 187: 1064 | Bryant D, J Med Virol
2011; 83: 1358 | Daayana S, Br J Cancer 2010; 102: 1129 | de Sanjos S, Eur J
Cancer 2013; 49: 3450 | Gasco M, Oncogene 2002; 21: 1876 | Winters U, Clin
Cancer Res 2008; 14: 5292
Greece de Sanjos S, Eur J Cancer 2013; 49: 3450 | Tsimplaki E, J Oncol 2012; 2012:
893275
Italy Bonvicini F, J Med Virol 2005; 77: 102 | de Sanjos S, Eur J Cancer 2013; 49:
3450
Netherlands van Beurden M, Cancer 1995; 75: 2879 | van der Avoort IA, Int J Gynecol Pathol
2006; 25: 22 | van Esch EM, Int J Cancer 2014; 135: 830 | van Seters M, N Engl
J Med 2008; 358: 1465
Poland de Sanjos S, Eur J Cancer 2013; 49: 3450
Portugal de Sanjos S, Eur J Cancer 2013; 49: 3450
Oceania
Australia de Sanjos S, Eur J Cancer 2013; 49: 3450 | Tan SE, Sex Health 2013; 10: 18
New Zealand de Sanjos S, Eur J Cancer 2013; 49: 3450
HPV type distribution for invasive vaginal cancer
General sources Based on systematic reviews (up to 2008) performed by ICO for the IARC
Monograph on the Evaluation of Carcinogenic Risks to Humans volume 100B
and IARCs Infections and Cancer Epidemiology Group. The ICO HPV
Information Centre has updated data until June 2015. Reference publications: 1)
Bouvard V, Lancet Oncol 2009;10:321 2) De Vuyst H, Int J Cancer 2009;124:1626
Africa
Mozambique Alemany L, Eur J Cancer 2014; 50: 2846
Nigeria Alemany L, Eur J Cancer 2014; 50: 2846
Americas
Argentina Alemany L, Eur J Cancer 2014; 50: 2846
Brazil Alemany L, Eur J Cancer 2014; 50: 2846
Chile Alemany L, Eur J Cancer 2014; 50: 2846
Colombia Alemany L, Eur J Cancer 2014; 50: 2846
Ecuador Alemany L, Eur J Cancer 2014; 50: 2846
Guatemala Alemany L, Eur J Cancer 2014; 50: 2846
Mexico Alemany L, Eur J Cancer 2014; 50: 2846
Paraguay Alemany L, Eur J Cancer 2014; 50: 2846
Uruguay Alemany L, Eur J Cancer 2014; 50: 2846
USA Alemany L, Eur J Cancer 2014; 50: 2846 | Carter JJ, Cancer Res 2001; 61: 1934
| Daling JR, Gynecol Oncol 2002; 84: 263 | Kiyabu MT, Am J Surg Pathol 1989;
13: 221
Venezuela Alemany L, Eur J Cancer 2014; 50: 2846
(Continued)
Table 32 Continued
Country Study
Asia
Bangladesh Alemany L, Eur J Cancer 2014; 50: 2846
India Alemany L, Eur J Cancer 2014; 50: 2846
Israel Alemany L, Eur J Cancer 2014; 50: 2846
Japan Koyamatsu Y, Gynecol Oncol 2003; 90: 547
Republic of Korea Alemany L, Eur J Cancer 2014; 50: 2846
Kuwait Alemany L, Eur J Cancer 2014; 50: 2846
Lebanon Alemany L, Eur J Cancer 2014; 50: 2846
Philippines Alemany L, Eur J Cancer 2014; 50: 2846
Turkey Alemany L, Eur J Cancer 2014; 50: 2846
Taiwan Alemany L, Eur J Cancer 2014; 50: 2846
Europe
Austria Alemany L, Eur J Cancer 2014; 50: 2846
Belarus Alemany L, Eur J Cancer 2014; 50: 2846
Czech Republic Alemany L, Eur J Cancer 2014; 50: 2846
Germany Alemany L, Eur J Cancer 2014; 50: 2846
Denmark Madsen BS, Int J Cancer 2008; 122: 2827
Spain Alemany L, Eur J Cancer 2014; 50: 2846 | Fuste V, Histopathology 2010; 57: 907
France Alemany L, Eur J Cancer 2014; 50: 2846
United Kingdom Alemany L, Eur J Cancer 2014; 50: 2846
Greece Alemany L, Eur J Cancer 2014; 50: 2846
Poland Alemany L, Eur J Cancer 2014; 50: 2846
Portugal Ferreira M, Mod Pathol 2008; 21: 968
Sweden Larsson GL, Gynecol Oncol 2013; 129: 406
Oceania
Australia Alemany L, Eur J Cancer 2014; 50: 2846
HPV type distribution for vaginal intraepithelial neoplasia (VAIN)
General sources Based on systematic reviews (up to 2008) performed by ICO for the IARC
Monograph on the Evaluation of Carcinogenic Risks to Humans volume 100B
and IARCs Infections and Cancer Epidemiology Group. The ICO HPV
Information Centre has updated data until June 2015. Reference publications: 1)
Bouvard V, Lancet Oncol 2009;10:321 2) De Vuyst H, Int J Cancer 2009;124:1626
Americas
Argentina Alemany L, Eur J Cancer 2014; 50: 2846
Brazil Alemany L, Eur J Cancer 2014; 50: 2846
Chile Alemany L, Eur J Cancer 2014; 50: 2846
Colombia Alemany L, Eur J Cancer 2014; 50: 2846
Ecuador Alemany L, Eur J Cancer 2014; 50: 2846
Guatemala Alemany L, Eur J Cancer 2014; 50: 2846
Mexico Alemany L, Eur J Cancer 2014; 50: 2846
Paraguay Alemany L, Eur J Cancer 2014; 50: 2846
Uruguay Alemany L, Eur J Cancer 2014; 50: 2846
USA Alemany L, Eur J Cancer 2014; 50: 2846 | Daling JR, Gynecol Oncol 2002; 84:
263 | Srodon M, Am J Surg Pathol 2006; 30: 1513
Venezuela Alemany L, Eur J Cancer 2014; 50: 2846
Asia
Bangladesh Alemany L, Eur J Cancer 2014; 50: 2846
India Alemany L, Eur J Cancer 2014; 50: 2846
Israel Alemany L, Eur J Cancer 2014; 50: 2846
Japan Sugase M, Int J Cancer 1997; 72: 412
Republic of Korea Alemany L, Eur J Cancer 2014; 50: 2846
Kuwait Alemany L, Eur J Cancer 2014; 50: 2846
Lebanon Alemany L, Eur J Cancer 2014; 50: 2846
(Continued)
Table 32 Continued
Country Study
Philippines Alemany L, Eur J Cancer 2014; 50: 2846
Turkey Alemany L, Eur J Cancer 2014; 50: 2846
Taiwan Alemany L, Eur J Cancer 2014; 50: 2846
Europe
Austria Alemany L, Eur J Cancer 2014; 50: 2846
Belarus Alemany L, Eur J Cancer 2014; 50: 2846
Czech Republic Alemany L, Eur J Cancer 2014; 50: 2846
Germany Alemany L, Eur J Cancer 2014; 50: 2846 | Hampl M, J Cancer Res Clin Oncol
2007; 133: 235 | Hampl M, Obstet Gynecol 2006; 108: 1361
Spain Alemany L, Eur J Cancer 2014; 50: 2846
France Alemany L, Eur J Cancer 2014; 50: 2846
United Kingdom Alemany L, Eur J Cancer 2014; 50: 2846
Greece Alemany L, Eur J Cancer 2014; 50: 2846 | Tsimplaki E, J Oncol 2012; 2012:
893275
Italy Frega A, Cancer Lett 2007; 249: 235
Poland Alemany L, Eur J Cancer 2014; 50: 2846
Oceania
Australia Alemany L, Eur J Cancer 2014; 50: 2846
HPV type distribution for invasive penile cancer
General sources The ICO HPV Information Centre has updated data until June 2015. Reference
publications (up to 2008): 1) Bouvard V, Lancet Oncol 2009;10:321 2)
Miralles-Guri C,J Clin Pathol 2009;62:870
Africa
Uganda Tornesello ML, Cancer Lett 2008; 269: 159
South Africa Lebelo RL, J Med Virol 2014; 86: 257
Americas
Argentina Picconi MA, J Med Virol 2000; 61: 65
Brazil Afonso LA, Mem Inst Oswaldo Cruz 2012; 107: 18 | Bezerra AL, Cancer 2001;
91: 2315 | Calmon MF, PLoS ONE 2013; 8: e53260 | de Sousa ID, BMC Urol
2015; 15: 13 | Fonseca AG, Int Braz J Urol 2013; 39: 542 | Levi JE, Int J Cancer
1998; 76: 779 | Scheiner MA, Int Braz J Urol 2008; 34: 467
Canada Maden C, J Natl Cancer Inst 1993; 85: 19
Mexico Lpez-Romero R, Int J Clin Exp Pathol 2013; 6: 1409 | Salazar EL, Arch Androl
2005; 51: 327
Paraguay Cubilla AL, Am J Surg Pathol 2010; 34: 104 | Gregoire L, J Natl Cancer Inst
1995; 87: 1705 | Rubin MA, Am J Pathol 2001; 159: 1211
USA Alemany L, Eur Urol 2016; 69: 953 | Cupp MR, J Urol 1995; 154: 1024 | Daling
JR, Int J Cancer 2005; 116: 606 | Gregoire L, J Natl Cancer Inst 1995; 87: 1705
| Hernandez BY, Front Oncol 2014; 4: 9 | Rubin MA, Am J Pathol 2001; 159:
1211 | Sarkar FH, J Urol 1992; 147: 389 | Varma VA, Hum Pathol 1991; 22: 908
Asia
China Chan KW, J Clin Pathol 1994; 47: 823
Japan Iwasawa A, J Urol 1993; 149: 59 | Suzuki H, Jpn J Clin Oncol 1994; 24: 1 |
Yanagawa N, Pathol Int 2008; 58: 477
Thailand Senba M, J Med Virol 2006; 78: 1341
Viet Nam Do HT, Br J Cancer 2013; 108: 229
Europe
Austria Mannweiler S, J Am Acad Dermatol 2013; 69: 73
Belgium DHauwers KW, Vaccine 2012; 30: 6573
Germany Perceau G, Br J Dermatol 2003; 148: 934 | Poetsch M, Virchows Arch 2011; 458:
221
Denmark Krustrup D, Int J Exp Pathol 2009; 90: 182
Spain Ferrndiz-Pulido C, J Am Acad Dermatol 2013; 68: 73 | Guerrero D, BJU Int
2008; 102: 747 | Pascual A, Histol Histopathol 2007; 22: 177
(Continued)
Table 32 Continued
Country Study
France Humbey O, Eur J Cancer 2003; 39: 684 | Perceau G, Br J Dermatol 2003; 148:
934
United Kingdom Prowse DM, Br J Dermatol 2008; 158: 261 | Stankiewicz E, Histopathology
2011; 58: 433
Italy Barzon L, Am J Pathol 2014; 184: 3376 | Gentile V, Int J Immunopathol
Pharmacol 2006; 19: 209 | Tornesello ML, Cancer Lett 2008; 269: 159
Netherlands Heideman DA, J Clin Oncol 2007; 25: 4550 | Lont AP, Int J Cancer 2006; 119:
1078
Sweden Kirrander P, BJU Int 2011; 108: 355
HPV type distribution for penile intraepithelial neoplasia (PEIN)
General sources The ICO HPV Information Centre has updated data until June 2014. Reference
publication (up to 2008): Bouvard V, Lancet Oncol 2009;10:321
Americas
Mexico Lpez-Romero R, Int J Clin Exp Pathol 2013; 6: 1409
USA Cupp MR, J Urol 1995; 154: 1024
Europe
Austria Mannweiler S, J Am Acad Dermatol 2013; 69: 73
Belgium DHauwers KW, Vaccine 2012; 30: 6573
Sweden Kirrander P, BJU Int 2011; 108: 355 | Wikstrm A, J Eur Acad Dermatol
Venereol 2012; 26: 325
The anogenital prevalence of HPV-DNA in men: HPV in men
General sources Based on published systematic reviews, the ICO HPV Information Centre has
updated data until September 2014. Reference publications: 1) Dunne EF, J
Infect Dis 2006; 194: 1044 2) Smith JS, J Adolesc Health 2011; 48: 540 3) Olesen
TB, Sex Transm Infect 2014; 90: 455 4) Hebnes JB, J Sex Med 2014; 11: 2630.
Africa
Kenya Ngayo MO, Sex Transm Infect 2008; 84: 62 | Smith JS, Int J Cancer 2010; 126:
572
Rwanda Veldhuijzen NJ, Sex Transm Dis 2012; 39: 128
Tanzania Olesen TB, Sex Transm Dis 2013; 40: 592
South Africa Auvert B, J Acquir Immune Defic Syndr 2010; 53: 111
Americas
Brazil Franceschi S, Br J Cancer 2002; 86: 705 | Giuliano AR, Cancer Epidemiol
Biomarkers Prev 2008; 17: 2036 | Nyitray AG, J Infect Dis 2011; 203: 49 |
Rosenblatt C, Int J Gynaecol Obstet 2004; 84: 156
Chile Guzmn P, Rev Med Chil 2008; 136: 1381
Colombia Franceschi S, Br J Cancer 2002; 86: 705
Mexico Giuliano AR, Cancer Epidemiol Biomarkers Prev 2008; 17: 2036 | Lajous M,
Cancer Epidemiol Biomarkers Prev 2005; 14: 1710 | Lazcano-Ponce E, Sex
Transm Dis 2001; 28: 277 | Nyitray AG, J Infect Dis 2011; 203: 49 |
Snchez-Alemn MA, Salud Publica Mex 2002; 44: 442 | Vaccarella S, Int J
Cancer 2006; 119: 1934
USA Giuliano AR, J Infect Dis 2008; 198: 827 | Giuliano AR, Cancer Epidemiol
Biomarkers Prev 2008; 17: 2036 | Hernandez BY, J Infect Dis 2008; 197: 787 |
Nielson CM, Cancer Epidemiol Biomarkers Prev 2007; 16: 1107 | Nyitray AG, J
Infect Dis 2011; 203: 49 | Partridge JM, J Infect Dis 2007; 196: 1128 | Weaver
BA, J Infect Dis 2004; 189: 677
Asia
China Liu M, Cancer Epidemiol Biomarkers Prev 2014
India Gupta A, J Clin Virol 2006; 37: 190
Japan Takahashi S, Sex Transm Dis 2003; 30: 629
Republic of Korea Shin HR, J Infect Dis 2004; 190: 468
Philippines Franceschi S, Br J Cancer 2002; 86: 705
Thailand Franceschi S, Br J Cancer 2002; 86: 705
(Continued)
Table 32 Continued
Country Study
Europe
Germany Grussendorf-Conen EI, Arch Dermatol Res 1987; 279 Suppl: S73
Denmark Kjaer SK, Cancer Epidemiol Biomarkers Prev 2005; 14: 1528
Spain Franceschi S, Br J Cancer 2002; 86: 705
Finland Hippelinen M, Sex Transm Dis 1993; 20: 321 | Kero K, J Sex Med 2011; 8: 2522
Croatia Grce M, Anticancer Res 1996; 16: 1039
Italy Lorenzon L, J Clin Virol 2014; 60: 264 | Nasca MR, Int J Dermatol 2006; 45: 681
Sweden Forslund O, J Clin Microbiol 1993; 31: 1975 | Kataoka A, J Med Virol 1991; 33:
159
The anogenital prevalence of HPV-DNA in men: HPV in special subgroups (HIV, MSM, etc)
General sources Based on published systematic reviews, the ICO HPV Information Centre has
updated data until September 2014. Reference publications: 1) Dunne EF, J
Infect Dis 2006; 194: 1044 2) Smith JS, J Adolesc Health 2011; 48: 540 3) Olesen
TB, Sex Transm Infect 2014; 90: 455 4) Hebnes JB, J Sex Med 2014; 11: 2630.
Africa
Uganda Tobian AA, Sex Transm Infect 2013; 89: 122
South Africa Firnhaber C, Int J STD AIDS 2011; 22: 107 | Mbulawa ZZ, J Gen Virol 2010; 91:
3023 | Mller EE, Sex Transm Infect 2010; 86: 175 | Vogt SL, Front Oncol 2013;
3: 60
Americas
Brazil de Lima Rocha MG, PLoS ONE 2012; 7: 105 | Franceschi S, Br J Cancer 2002;
86: 705 | Freire MP, Int Braz J Urol 2014; 40: 67 | Goldstone S, J Infect Dis
2011; 203: 66 | Guimares MD, J Acquir Immune Defic Syndr 2011; 57 Suppl 3:
S217 | Nicolau SM, Urology 2005; 65: 251 | Nyitray AG, J Infect Dis 2011; 203:
49 | Rombaldi RL, Braz J Med Biol Res 2006; 39: 177 | Rosenblatt C, Int J
Gynaecol Obstet 2004; 84: 156 | Vardas E, J Infect Dis 2011; 203: 58
Canada de Pokomandy A, J Infect Dis 2009; 199: 965 | Goldstone S, J Infect Dis 2011;
203: 66 | Ogilvie GS, Sex Transm Infect 2009; 85: 221 | Salit IE, Cancer
Epidemiol Biomarkers Prev 2009; 18: 1986 | Salit IE, AIDS 2010; 24: 1307 |
Vardas E, J Infect Dis 2011; 203: 58
Colombia Franceschi S, Br J Cancer 2002; 86: 705
Mexico Goldstone S, J Infect Dis 2011; 203: 66 | Leyva-Lpez AG, Salud Publica Mex
2003; 45 Supp 5: S589 | Nyitray AG, J Infect Dis 2011; 203: 49 | Torres-Ibarra
L, Prev Med 2014; 69C: 157 | Vardas E, J Infect Dis 2011; 203: 58
USA Baken LA, J Infect Dis 1995; 171: 429 | Baldwin SB, J Infect Dis 2003; 187:
1064 | Berry JM, Dis Colon Rectum 2009; 52: 239 | Caussy D, Int J Cancer
1990; 46: 214 | Chin-Hong PV, J Infect Dis 2004; 190: 2070 | Chin-Hong PV,
Ann Intern Med 2008; 149: 300 | Coln-Lpez V, PLoS ONE 2014; 9: 109 |
Conley L, J Infect Dis 2010; 202: 1567 | Critchlow CW, AIDS 1998; 12: 1177 |
Fife KH, Sex Transm Dis 2003; 30: 246 | Friedman HB, J Infect Dis 1998; 178:
45 | Goldstone S, J Infect Dis 2011; 203: 66 | Kiviat NB, AIDS 1993; 7: 43 |
Moscicki AB, AIDS 2003; 17: 311 | Nyitray AG, J Infect Dis 2011; 203: 49 |
Palefsky JM, Genitourin Med 1997; 73: 174 | Palefsky JM, J Infect Dis 1998;
177: 361 | Palefsky JM, AIDS 2005; 19: 1407 | Vardas E, J Infect Dis 2011; 203:
58 | Wiley DJ, PLoS ONE 2013; 8: 108 | Wilkin TJ, J Infect Dis 2004; 190: 1685
Asia
China Gao L, PLoS ONE 2010; 5: 103 | Tang X, Biomed Environ Sci 2006; 19: 153 |
Yang Y, PLoS ONE 2012; 7: 104 | Zhang DY, PLoS ONE 2014; 9: 111
India Gupta A, J Clin Virol 2006; 37: 190
Japan Shigehara K, Int J Urol 2010; 17: 563 | Takahashi S, Sex Transm Dis 2003; 30:
629 | Takahashi S, J Infect Chemother 2005; 11: 270
Philippines Franceschi S, Br J Cancer 2002; 86: 705
Thailand Franceschi S, Br J Cancer 2002; 86: 705 | Phanuphak N, J Acquir Immune Defic
Syndr 2013; 63: 472
(Continued)
Table 32 Continued
Country Study
Europe
Germany Goldstone S, J Infect Dis 2011; 203: 66 | Schneider A, J Urol 1988; 140: 1431 |
Vardas E, J Infect Dis 2011; 203: 58
Denmark Svare EI, Sex Transm Infect 2002; 78: 215
Spain lvarez-Argelles ME, PLoS ONE 2013; 8: 106 | Franceschi S, Br J Cancer
2002; 86: 705 | Goldstone S, J Infect Dis 2011; 203: 66 | Sendagorta E, Dis
Colon Rectum 2014; 57: 475 | Torres M, J Clin Microbiol 2013; 51: 3512 |
Vardas E, J Infect Dis 2011; 203: 58 | Videla S, Sex Transm Dis 2013; 40: 03
France Aynaud O, Urology 2003; 61: 1098 | Damay A, J Med Virol 2010; 82: 592 |
Piketty C, Sex Transm Dis 2004; 31: 96
United Kingdom Bissett SL, J Med Virol 2011; 83: 1744 | Cuschieri K, J Med Virol 2011; 83: 1983
| Hillman RJ, Genitourin Med 1993; 69: 187 | Jalal H, Int J STD AIDS 2007;
18: 617 | Lacey HB, Sex Transm Infect 1999; 75: 172
Greece Hadjivassiliou M, Int J STD AIDS 2007; 18: 329
Croatia Goldstone S, J Infect Dis 2011; 203: 66 | Vardas E, J Infect Dis 2011; 203: 58
Italy Barzon L, J Med Virol 2010; 82: 1424 | Benevolo M, J Med Virol 2008; 80: 1275
| Chiarini F, Minerva Urol Nefrol 1998; 50: 225 | Della Torre G, Am J Pathol
1992; 141: 1181 | Giovannelli L, J Clin Microbiol 2007; 45: 248 | Latini A, J Int
AIDS Soc 2014; 17: 39 | Orlando G, J Acquir Immune Defic Syndr 2008; 47: 129
| Pierangeli A, AIDS 2008; 22: 1929
Netherlands Bleeker MC, J Am Acad Dermatol 2002; 47: 351 | Bleeker MC, Int J Cancer
2005; 113: 36 | Bleeker MC, Clin Infect Dis 2005; 41: 612 | van der Snoek EM,
Sex Transm Dis 2003; 30: 639 | Van Doornum GJ, Genitourin Med 1994; 70: 240
| van Rijn VM, PLoS ONE 2014; 9: 110 | Vriend HJ, PLoS ONE 2013; 8: 107
Slovenia Golob B, Biomed Res Int 2014; 2014: 100 | Milosevic M, Cent Eur J Med 2010; 5:
698
Sweden Kataoka A, J Med Virol 1991; 33: 159 | Lwhagen GB, Int J STD AIDS 1999; 10:
615 | Strand A, Genitourin Med 1993; 69: 446 | Voog E, Int J STD AIDS 1997;
8: 772 | Wikstrm A, Int J STD AIDS 1991; 2: 105 | Wikstrm A, Int J STD
AIDS 2000; 11: 80
Oceania
Australia Anderson J, Sex Transm Infect 2008; 84: 94 | Goldstone S, J Infect Dis 2011;
203: 66 | Vajdic CM, Sex Transm Infect 2009; 85: 330 | Vardas E, J Infect Dis
2011; 203: 58
HPV prevalence and type distribution in oral specimens collected from healthy population
General sources Systematic review and meta-analysis was performed by ICO HPV Information
Centre until July 2012. Pubmed was searched using the keywords oral and
papillomavirus. Inclusion criteria: studies reporting oral HPV prevalence in
healthy population in Europe; n > 50. Exclusion criteria: focused only in children
or immunosuppressed population; not written in English; case-control studies;
commentaries and systematic reviews and studies that did not use HPV DNA
detection methods.
Europe
Denmark Eike A, Clin Otolaryngol 1995;20:171
Denmark Eike A, Clin Otolaryngol 1995;20:171
Spain Caadas MP, J Clin Microbiol 2004;42:1330
Spain Caadas MP, J Clin Microbiol 2004;42:1330
Finland Kero K, Eur Urol 2012;62(6):1063-70
Finland Leimola-Virtanen R, Clin Infect Dis 1996;22:593
Finland Kero K, J Sex Med 2011;8:2522
Finland Kero K, Eur Urol 2012;62(6):1063-70
Finland Leimola-Virtanen R, Clin Infect Dis 1996;22:593
Finland Kero K, J Sex Med 2011;8:2522
United Kingdom Kujan O, Oral Oncol 2006;42:810
United Kingdom Kujan O, Oral Oncol 2006;42:810
(Continued)
Table 32 Continued
Country Study
Greece Lambropoulos AF, Eur J Oral Sci 1997;105:294
Greece Lambropoulos AF, Eur J Oral Sci 1997;105:294
Italy Montaldo C, J Oral Pathol Med 2007;36:482
Italy Migaldi M, J Oral Pathol Med 2012;41:16
Italy Migaldi M, J Oral Pathol Med 2012;41:16
Italy Montaldo C, J Oral Pathol Med 2007;36:482
HPV prevalence and type distribution in invasive oral cavity squamous cell carcinoma
General sources Based on systematic reviews and meta-analysis performed by ICO. Reference
publications: 1) Ndiaye C, Lancet Oncol 2014; 15: 1319 2) Kreimer AR, Cancer
Epidemiol Biomarkers Prev 2005; 14: 467
Africa
Sudan Herrero R, J Natl Cancer Inst 2003; 95: 1772
South Africa Boy S, J Oral Pathol Med 2006; 35: 86 | Van Rensburg EJ, Anticancer Res 1996;
16: 969
Americas
Argentina Gonzlez JV, Medicina (B Aires) 2007; 67: 363 | Ribeiro KB, Int J Epidemiol
2011; 40: 489
Brazil Oliveira MC, Auris Nasus Larynx 2009; 36: 450 | Ribeiro KB, Int J Epidemiol
2011; 40: 489 | Rivero ER, Braz Oral Res 2006; 20: 21
Canada Herrero R, J Natl Cancer Inst 2003; 95: 1772 | Noble-Topham SE, Arch
Otolaryngol Head Neck Surg 1993; 119: 1299
Cuba Herrero R, J Natl Cancer Inst 2003; 95: 1772 | Ribeiro KB, Int J Epidemiol
2011; 40: 489
Mexico Anaya-Saavedra G, Arch Med Res 2008; 39: 189 | Ibieta BR, Oral Surg Oral
Med Oral Pathol Oral Radiol Endod 2005; 99: 311
USA Chuang AY, Oral Oncol 2008; 44: 915 | Furniss CS, Int J Cancer 2007; 120: 2386
| Ha PK, Clin Cancer Res 2002; 8: 1203 | Harris SL, Head Neck 2011; 33: 1622
| Holladay EB, Am J Clin Pathol 1993; 100: 36 | Liang XH, J Oral Maxillofac
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2009; 135: 180 | Paz IB, Cancer 1997; 79: 595 | Schlecht NF, Mod Pathol 2011;
24: 1295 | Schwartz SM, J Natl Cancer Inst 1998; 90: 1626 | Smith EM, Int J
Cancer 2004; 108: 766 | Zhao M, Int J Cancer 2005; 117: 605
Venezuela Miller CS, Oral Surg Oral Med Oral Pathol 1994; 77: 480 | Premoli-De-Percoco
G, J Oral Pathol Med 2001; 30: 355
Asia
China Tang X, J Oral Pathol Med 2003; 32: 393 | Wen S, Anticancer Res 1997; 17: 307
| Zhang ZY, Int J Oral Maxillofac Surg 2004; 33: 71
India Balaram P, Int J Cancer 1995; 61: 450 | Bhattacharya N, J Oral Pathol Med
2009; 38: 759 | Chaudhary AK, Virol J 2010; 7: 253 | DCosta J, Oral Oncol
1998; 34: 413 | Herrero R, J Natl Cancer Inst 2003; 95: 1772 | Mishra A, Int J
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Iran Saghravanian N, Acta Odontol Scand 2011; 69: 406
Japan Bhawal UK, Arch Otolaryngol Head Neck Surg 2008; 134: 1055 | Chiba I,
Oncogene 1996; 12: 1663 | Higa M, Oral Oncol 2003; 39: 405 | Kojima A, Oral
Oncol 2002; 38: 591 | Shima K, Br J Oral Maxillofac Surg 2000; 38: 445 |
Shimizu M, J Dermatol Sci 2004; 36: 33 | Sugiyama M, Oral Surg Oral Med
Oral Pathol Oral Radiol Endod 2003; 95: 594 | Tang X, J Oral Pathol Med 2003;
32: 393 | Tsuhako K, J Oral Pathol Med 2000; 29: 70
Republic of Korea Shin KH, Int J Oncol 2002; 21: 297
Malaysia Lim KP, Oncol Rep 2007; 17: 1321
Taiwan Chang JY, Am J Clin Pathol 2003; 120: 909 | Chen PC, J Oral Pathol Med 2002;
31: 317 | Yang YY, Jpn J Clin Oncol 2004; 34: 176
Europe
Czech Republic Ribeiro KB, Int J Epidemiol 2011; 40: 489
(Continued)
Table 32 Continued
Country Study
Germany Klussmann JP, Cancer 2001; 92: 2875 | Ostwald C, Med Microbiol Immunol
2003; 192: 145 | Weiss D, Head Neck 2011; 33: 856
Spain Herrero R, J Natl Cancer Inst 2003; 95: 1772 | Llamas-Martnez S, Anticancer
Res 2008; 28: 3733
Finland Koskinen WJ, Int J Cancer 2003; 107: 401 | Mork J, N Engl J Med 2001; 344:
1125
United Kingdom Lopes V, Oral Oncol 2011; 47: 698 | Snijders PJ, Int J Cancer 1996; 66: 464 |
Yeudall WA, J Gen Virol 1991; 72 ( Pt 1): 173
Greece Aggelopoulou EP, Anticancer Res 1999; 19: 1391 | Romanitan M, Anticancer Res
2008; 28: 2077
Hungary Nemes JA, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 344 |
Szarka K, Oral Microbiol Immunol 2009; 24: 314
Ireland Herrero R, J Natl Cancer Inst 2003; 95: 1772
Italy Badaracco G, Anticancer Res 2000; 20: 1301 | Badaracco G, Oncol Rep 2007; 17:
931 | Herrero R, J Natl Cancer Inst 2003; 95: 1772 | Ritt M, Head Neck 2009;
31: 318 | Scapoli L, Mod Pathol 2009; 22: 366
Netherlands Braakhuis BJ, J Natl Cancer Inst 2004; 96: 998 | Cruz IB, Eur J Cancer, B, Oral
Oncol 1996; 32B: 55
Norway Matzow T, Acta Oncol 1998; 37: 73 | Mork J, N Engl J Med 2001; 344: 1125
Poland Herrero R, J Natl Cancer Inst 2003; 95: 1772 | Ribeiro KB, Int J Epidemiol
2011; 40: 489 | Snietura M, Pol J Pathol 2010; 61: 133
Romania Ribeiro KB, Int J Epidemiol 2011; 40: 489
Russian Federation Ribeiro KB, Int J Epidemiol 2011; 40: 489
Serbia Kozomara R, J Craniomaxillofac Surg 2005; 33: 342
Slovakia Ribeiro KB, Int J Epidemiol 2011; 40: 489
Slovenia Kansky AA, Acta Virol 2003; 47: 11
Sweden Dahlgren L, Int J Cancer 2004; 112: 1015 | Mork J, N Engl J Med 2001; 344:
1125 | Sand L, Anticancer Res 2000; 20: 1183
HPV prevalence and type distribution in invasive oropharyngeal squamous cell carcinoma
General sources Based on systematic reviews and meta-analysis performed by ICO. Reference
publications: 1) Ndiaye C, Lancet Oncol 2014; 15: 1319 2) Kreimer AR, Cancer
Epidemiol Biomarkers Prev 2005; 14: 467
Americas
Argentina Ribeiro KB, Int J Epidemiol 2011; 40: 489
Brazil Cortezzi SS, Cancer Genet Cytogenet 2004; 150: 44 | Ribeiro KB, Int J
Epidemiol 2011; 40: 489
Cuba Herrero R, J Natl Cancer Inst 2003; 95: 1772 | Ribeiro KB, Int J Epidemiol
2011; 40: 489
USA Agoston ES, Am J Clin Pathol 2010; 134: 36 | Chaturvedi AK, J Clin Oncol 2011;
29: 4294 | Cohen MA, Acta Otolaryngol 2008; 128: 583 | DSouza G, N Engl J
Med 2007; 356: 1944 | Ernster JA, Laryngoscope 2007; 117: 2115 | Furniss CS,
Int J Cancer 2007; 120: 2386 | Kingma DW, Anticancer Res 2010; 30: 5099 |
Kong CS, Int J Radiat Oncol Biol Phys 2009; 74: 553 | Lohavanichbutr P, Arch
Otolaryngol Head Neck Surg 2009; 135: 180 | Posner MR, Ann Oncol 2011; 22:
1071 | Schlecht NF, Mod Pathol 2011; 24: 1295 | Schwartz SM, J Natl Cancer
Inst 1998; 90: 1626 | Smith EM, Int J Cancer 2004; 108: 766 | Strome SE, Clin
Cancer Res 2002; 8: 1093 | Tezal M, Arch Otolaryngol Head Neck Surg 2009;
135: 391 | Zhao M, Int J Cancer 2005; 117: 605
Asia
China Li W, Pathology 2007; 39: 217
Republic of Korea Kim SH, Int J Cancer 2007; 120: 1418 | Oh TJ, J Clin Microbiol 2004; 42: 3272
Taiwan Al-Swiahb JN, Arch Otolaryngol Head Neck Surg 2010; 136: 502 | Kuo KT, Mod
Pathol 2008; 21: 376
Europe
Switzerland Lindel K, Cancer 2001; 92: 805
(Continued)
Table 32 Continued
Country Study
Czech Republic Klozar J, Eur Arch Otorhinolaryngol 2008; 265 Suppl 1: S75 | Ribeiro KB, Int J
Epidemiol 2011; 40: 489 | Rotnglov E, Int J Cancer 2011; 129: 101
Germany Andl T, Cancer Res 1998; 58: 5 | Hoffmann M, Acta Otolaryngol 1998; 118: 138
| Hoffmann M, Int J Cancer 2010; 127: 1595 | Klussmann JP, Cancer 2001; 92:
2875 | Reimers N, Int J Cancer 2007; 120: 1731 | Weiss D, Head Neck 2011; 33:
856 | Wittekindt C, Adv Otorhinolaryngol 2005; 62: 72
Spain Herrero R, J Natl Cancer Inst 2003; 95: 1772
France Charfi L, Cancer Lett 2008; 260: 72 | Fouret P, Arch Otolaryngol Head Neck
Surg 1997; 123: 513
United Kingdom Anderson CE, J Clin Pathol 2007; 60: 439 | Schache AG, Clin Cancer Res 2011;
17: 6262 | Thavaraj S, J Clin Pathol 2011; 64: 308
Greece Romanitan M, Anticancer Res 2008; 28: 2077
Italy Boscolo-Rizzo P, J Cancer Res Clin Oncol 2009; 135: 559 | Herrero R, J Natl
Cancer Inst 2003; 95: 1772 | Licitra L, J Clin Oncol 2006; 24: 5630 | Ritt M,
Head Neck 2009; 31: 318
Netherlands Braakhuis BJ, J Natl Cancer Inst 2004; 96: 998
Norway Hannisdal K, Acta Otolaryngol 2010; 130: 293
Poland Ribeiro KB, Int J Epidemiol 2011; 40: 489 | Snietura M, Pol J Pathol 2010; 61:
133 | Szkaradkiewicz A, Clin Exp Med 2002; 2: 137
Romania Ribeiro KB, Int J Epidemiol 2011; 40: 489
Russian Federation Ribeiro KB, Int J Epidemiol 2011; 40: 489
Slovakia Ribeiro KB, Int J Epidemiol 2011; 40: 489
Sweden Attner P, Int J Cancer 2010; 126: 2879 | Dahlgren L, Int J Cancer 2004; 112:
1015 | Hammarstedt L, Int J Cancer 2006; 119: 2620 | Lindquist D, Anticancer
Res 2012; 32: 153 | Nsman A, Int J Cancer 2009; 125: 362
Oceania
Australia Hong AM, Vaccine 2010; 28: 3269
HPV prevalence and type distribution in invasive hypopharyngeal squamous cell carcinoma
General sources Based on systematic reviews and meta-analysis performed by ICO. Reference
publications: 1) Ndiaye C, Lancet Oncol 2014; 15: 1319 2) Kreimer AR, Cancer
Epidemiol Biomarkers Prev 2005; 14: 467
Americas
Argentina Ribeiro KB, Int J Epidemiol 2011; 40: 489
Brazil Miranda FA, J Histochem Cytochem 2009; 57: 665 | Ribeiro KB, Int J Epidemiol
2011; 40: 489
Canada Fliss DM, Laryngoscope 1994; 104: 146
Chile Torrente MC, Acta Otolaryngol 2005; 125: 888
Cuba Garca-Milin R, Acta Otolaryngol 1998; 118: 754 | Ribeiro KB, Int J Epidemiol
2011; 40: 489
USA Brandwein MS, Ann Otol Rhinol Laryngol 1993; 102: 309 | Furniss CS, Int J
Cancer 2007; 120: 2386 | Paz IB, Cancer 1997; 79: 595 | Schlecht NF, Mod
Pathol 2011; 24: 1295 | Shen J, Mod Pathol 1996; 9: 15 | Zhao M, Int J Cancer
2005; 117: 605
Asia
China Liu B, Neoplasma 2010; 57: 594 | Ma XL, J Med Virol 1998; 54: 186
India Jacob SE, J Surg Oncol 2002; 79: 142
Japan Anwar K, Int J Cancer 1993; 53: 22 | Mineta H, Anticancer Res 1998; 18: 4765 |
Ogura H, Jpn J Cancer Res 1991; 82: 1184 | Shidara K, Laryngoscope 1994;
104: 1008
Turkey Bozdayi G, J Otolaryngol Head Neck Surg 2009; 38: 119 | Dnmez M, Kuwait
Med J 2000 | Gungor A, J Laryngol Otol 2007; 121: 772
Europe
Belgium Duray A, Int J Oncol 2011; 39: 51
Switzerland Adams V, Anticancer Res 1999; 19: 1
(Continued)
Table 32 Continued
Country Study
Czech Republic Ribeiro KB, Int J Epidemiol 2011; 40: 489
Germany Fischer M, Acta Otolaryngol 2003; 123: 752 | Hoffmann M, Acta Otolaryngol
1998; 118: 138 | Hoffmann M, Anticancer Res 2006; 26: 663 | Hoffmann M,
Oncol Rep 2009; 21: 809 | Kleist B, J Oral Pathol Med 2000; 29: 432 |
Klussmann JP, Cancer 2001; 92: 2875
Denmark Lindeberg H, Cancer Lett 1999; 146: 9
Spain Alvarez Alvarez I, Am J Otolaryngol 1997; 18: 375 | Prez-Ayala M, Int J
Cancer 1990; 46: 8
Finland Koskinen WJ, Int J Cancer 2003; 107: 401 | Koskinen WJ, J Cancer Res Clin
Oncol 2007; 133: 673 | Mork J, N Engl J Med 2001; 344: 1125
France Fouret P, Arch Otolaryngol Head Neck Surg 1997; 123: 513
United Kingdom Anderson CE, J Clin Pathol 2007; 60: 439 | Salam M, Eur J Surg Oncol 1995;
21: 290 | Snijders PJ, Int J Cancer 1996; 66: 464
Greece Gorgoulis VG, Hum Pathol 1999; 30: 274 | Vlachtsis K, Eur Arch
Otorhinolaryngol 2005; 262: 890
Hungary Major T, J Clin Pathol 2005; 58: 51
Italy Azzimonti B, Histopathology 2004; 45: 560 | Badaracco G, Anticancer Res 2000;
20: 1301 | Badaracco G, Oncol Rep 2007; 17: 931 | Boscolo-Rizzo P, J Cancer
Res Clin Oncol 2009; 135: 559 | Cattani P, Clin Cancer Res 1998; 4: 2585 |
Gallo A, Otolaryngol Head Neck Surg 2009; 141: 276
Lithuania Gudleviciene Z, Oncology 2009; 76: 205
Norway Koskinen WJ, J Cancer Res Clin Oncol 2007; 133: 673 | Lie ES, Acta
Otolaryngol 1996; 116: 900 | Mork J, N Engl J Med 2001; 344: 1125
Poland Morshed K, Eur Arch Otorhinolaryngol 2008; 265 Suppl 1: S89 | Ribeiro KB, Int
J Epidemiol 2011; 40: 489 | Snietura M, Eur Arch Otorhinolaryngol 2011; 268:
721
Romania Ribeiro KB, Int J Epidemiol 2011; 40: 489
Russian Federation Ribeiro KB, Int J Epidemiol 2011; 40: 489
Slovakia Ribeiro KB, Int J Epidemiol 2011; 40: 489
Slovenia Poljak M, Acta Otolaryngol Suppl 1997; 527: 66
Sweden Koskinen WJ, J Cancer Res Clin Oncol 2007; 133: 673 | Mork J, N Engl J Med
2001; 344: 1125
10 Glossary
Table 33 Continued
Term Definition
Cervical Intraepithelial SIL and CIN are two commonly used terms to describe precancerous lesions or
Neoplasia (CIN) / the abnormal growth of squamous cells observed in the cervix. SIL is an
Squamous Intraepithelial abnormal result derived from cervical cytological screening or Pap smear testing.
Lesions (SIL) CIN is a histological diagnosis made upon analysis of cervical tissue obtained by
biopsy or surgical excision. The condition is graded as CIN 1, 2 or 3, according to
the thickness of the abnormal epithelium (1/3, 2/3 or the entire thickness).
Low-grade cervical lesions Low-grade cervical lesions are defined by early changes in size, shape, and
(LSIL/CIN-1) number of ab-normal cells formed on the surface of the cervix and may be
referred to as mild dysplasia, LSIL, or CIN-1.
High-grade cervical High-grade cervical lesions are defined by a large number of precancerous cells
lesions (HSIL / CIN-2 / on the sur-face of the cervix that are distinctly different from normal cells. They
CIN-3 / CIS) have the potential to become cancerous cells and invade deeper tissues of the
cervix. These lesions may be referred to as moderate or severe dysplasia, HSIL,
CIN-2, CIN-3 or cervical carcinoma in situ (CIS).
Carcinoma in situ (CIS) Preinvasive malignancy limited to the epithelium without invasion of the
basement membrane. CIN 3 encompasses the squamous carcinoma in situ.
Invasive cervical cancer If the high-grade precancerous cells invade the basement membrane is called
(ICC) / Cervical cancer ICC. ICC stages range from stage I (cancer is in the cervix or uterus only) to
stage IV (the cancer has spread to distant organs, such as the liver).
Invasive squamous cell Invasive carcinoma composed of cells resembling those of squamous epithelium
carcinoma
Adenocarcinoma Invasive tumour with glandular and squamous elements intermingled.
Eastern Europe References included in Belarus, Bulgaria, Czech Republic, Hungary, Poland,
Republic of Moldova, Romania, Russian Federation, Slovakia, and Ukraine.
Northern Europe References included in Denmark, Estonia, Finland, Iceland, Ireland, Latvia,
Lithuania, Norway, Sweden, and United Kingdom of Great Britain and Northern
Ireland.
Southern Europe References included in Albania, Bosnia and Herzegovina, Croatia, Greece, Italy,
Malta, Montenegro, Portugal, Serbia, Slovenia, Spain, The former Yugoslav
Republic of Macedonia.
Western Europe References included in Austria, Belgium, France, Germany, Liechtenstein,
Luxembourg, Netherlands, and Switzerland.
Europe PREHDICT References included in Albania, Austria, Belarus, Belgium, Bosnia and
Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy,
Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, Montenegro,
Netherlands, Norway, Poland, Portugal, Republic of Moldova, Romania, Russian
Federation, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, The former
Yugoslav Republic of Macedonia, Turkey, Ukraine, and United Kingdom of Great
Britain and Northern Ireland.
Acknowledgments
This report has been developed by the Unit of Infections and Cancer, Cancer Epidemiology Research
Program, at the Institut Catal dOncologia (ICO, Catalan Institute of Oncology) within the PREHDICT
project (7th Framework Programme grant HEALTH-F3-2010-242061, PREHDICT). The HPV Informa-
tion Centre is being developed by the Institut Catal dOncologia (ICO). The Centre was originally
launched by ICO with the collaboration of WHOs Immunisation, Vaccines and Biologicals (IVB) depart-
ment and support from the Bill and Melinda Gates Foundation.
7th Framework Programme grant HPV AHEAD project: Role of human papillomavirus infec-
tion and other co-factors in the aetiology of head and neck cancer in India and Europe. Coordinated by
Dr. Massimo Tommasino at IARC, International Agency of Research on Cancer, Lyon, France.
(http://cordis.europa.eu/project/rcn/100268_en.html)
Although efforts have been made by the HPV Information Centre to prepare and include as accurately
as possible the data presented, mistakes may occur. Readers are requested to communicate any errors
to the HPV Information Centre, so that corrections can be made in future volumes.
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