Acne and Whey Protein Supplementation Among Bodybuilders PDF
Acne and Whey Protein Supplementation Among Bodybuilders PDF
Key Words terium acnes follicular colonization and dence that a low glycemic load diet reduc-
Acne Whey protein Bodybuilding Diet (4) release of inflammatory mediators in- es the size of sebaceous glands, decreases
to the skin [1, 2]. However, the exact se- inflammation and diminishes the expres-
quence of events and how they interact re- sion of proinflammatory interleukin 8
Abstract mains unclear. There is a strong genetic and sterol regulatory element binding
Accumulative evidence supports the role of predisposition toward developing acne. protein 1 which is the key transcription
nutritional factors in acne. I report here 5 Other factors including cosmetics, envi- factor of lipid biosynthesis [9]. Particular
healthy male adult patients developing ac- ronment, hormones and stress are also attention has been paid to the role of the
ne after the consumption of whey protein, a involved in the development of acne. Al- ingestion of products containing refined
favorite supplement of those engaged in though dietary factors have long been sugar and certain dairy products (espe-
bodybuilding. These observations are in line considered unimportant, accumulative cially skim milk, sherbet drinks and cot-
with biochemical and epidemiological data evidence supports the role of nutritional tage cheese) [25]. Risk has been found to
supporting the effects of milk and dairy factors in acne [29]. The apparent ab- increase with an increased consumption
products as enhancers of insulin/insulin-like sence of acne in native non-Westernized of milk by individuals consuming more
growth factor 1 signaling and acne aggra- populations, e.g. the Kitavan Islanders of than 3 portions per week [4]. Milk con-
vation. Further prospective studies are re- Papua New Guinea and the Ach hunter- tains anabolic steroids as well as true
quired to determine the possible role of di- gatherers of Paraguay [6], has led to the growth hormones and other growth fac-
etary supplements in the fitness and body- proposal that high glycemic loads in the tors. The presence of 5-pregnanedione,
building environment. Western diet could have a role in acne, 5-androstanedione and other precursors
Copyright 2012 S. Karger AG, Basel perhaps through hyperinsulinemia lead- of 5-dihydrotestosterone add to the po-
ing to increased androgens, altered reti- tency of milk as a stimulant of acne [8].
noid signaling and increased insulin-like Future studies are required to determine
Introduction growth factor 1 (IGF-1) [68]. IGF-1 stim- if dietary modification will reduce long-
ulates basal keratinocyte proliferation term acne burden.
Acne is an androgen-dependent disor- and sebum production. It also participates The development or aggravation of
der of pilosebaceous follicles (or a pilose- in increasing the effect of circulating acne after the consumption of whey pro-
baceous unit). There are four primary androgens. A variety of clinical studies tein, a favorite nutritional supplement of
pathogenic factors which interact to pro- showing that a high glycemic load diet those engaged in bodybuilding, is scarcely
duce acne lesions: (1) increased and al- plays a role in acne exacerbation and, in- reported in the medical literature. I report
tered sebum production under androgen versely, that a low glycemic load diet might here 5 healthy male adult patients develop-
control (or increased androgen receptor improve acne, provide further support for ing acne after the consumption of whey
sensitivity), (2) altered keratinization this theory [49]. There is also histopath- protein concentrates.
leading to comedones, (3) Propionibac- ological and immunohistochemical evi-
Age, years BMI Frequency of whey protein Other supplements Self-reported acne GAGS
consumption/week during adolescence score
References
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