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Am J Clin Nutr 2016 Maughan 717 23
Am J Clin Nutr 2016 Maughan 717 23
ABSTRACT that body water balance fluctuates over the course of a normal
Background: The identification of beverages that promote longer- day, but generally returns to the same point over a 24-h cycle (1).
term fluid retention and maintenance of fluid balance is of real clinical Consequently, large fluid deficits are uncommon for the majority
and practical benefit in situations in which free access to fluids is of the population, but knowledge of beverages that can maintain
Am J Clin Nutr 2016;103:71723. Printed in USA. 2016 American Society for Nutrition 717
718 MAUGHAN ET AL.
Therefore, the aim of the present study was to assess fluid cluded. Because body mass was used as an index of euhydration,
balance responses to the ingestion of a fixed volume of commonly those currently undertaking an energy-restricted diet and/or
consumed beverages ingested when in a euhydrated state, with exercise plan also were excluded. Participants were asked to
a view to establishing the feasibility of a BHI. We hypothesized record their diet, including their fluid intake (household mea-
that drinks containing a high electrolyte content or high energy sures technique), as well as any exercise performed, in a diary
content would have greater fluid retention and thus a higher BHI over the 2 d before the first trial and asked to replicate this
than plain water. Conversely, drinks containing nutrients with before their subsequent visits. Participants also were asked not
known diuretic actions, such as alcohol and caffeine, may have to perform any strenuous exercise or consume alcoholic bever-
lower BHI values. ages in the 24 h preceding all trials.
TABLE 3 were ingested, cumulative urine mass was lower and net fluid
Institutional comparison of pretrial standardization and urine output balance was higher for full-fat milk (P , 0.01), skimmed milk
response to a standard drink1 (P , 0.01), and ORS (P , 0.01), but not orange juice (P =
0.06). The effect sizes at 4 h for cumulative urine output com-
Bangor Loughborough Stirling
(n = 24) (n = 24) (n = 24) P pared with still water were 1.04 for full-fat milk, 0.85 for
skimmed milk, and 1.09 for ORS (all large effects), with an
Preingestion of still water effect size of 0.65 for orange juice (a medium effect). The mean
Body mass, kg 76.1 6 12.3 76.7 6 7.3 78.2 6 9.7 0.76 differences in cumulative urine output were 294 g (95% CI: 154,
Serum osmolality, 293 68 291 6 4 295 6 3 0.14
434) for full-fat milk, 339 g (95% CI: 190, 489) for skimmed
mmol/kg
Urine osmolality, 564 6 243 607 6 302 538 6 176 0.62 milk, and 362 g (95% CI: 222, 505) for ORS.
mmol/kg
Postingestion of still water BHI
Urine mass, g 1341 6 360 1337 6 352 1333 6 288 0.99
After 2 h, full-fat milk, skimmed milk, ORS, and orange juice
1
Values are means 6 SDs. P values shown were obtained from a 1-factor had a higher BHI than still water (all differences P , 0.05)
repeated-measures ANOVA. No differences were observed between institu-
(Figure 2). The effect sizes at 2 h were 1.22 for full-fat milk,
tions for body mass, serum osmolality, or urine osmolality immediately
before still-water ingestion or 4-h cumulative urine mass after 1 L still water 1.37 for skimmed milk, 1.03 for ORS, and 0.87 for orange juice
ingestion, suggesting at each institution that participants preparation for (all large to very large effects). The higher BHI between still
trials was similar and that participants in the 3 institutions had similar fluid water and full-fat milk, skimmed milk, ORS, and orange juice
regulation. also exceeded twice the CV of the BHI measure. Mean
DEVELOPMENT OF A BEVERAGE HYDRATION INDEX 721
with positive sodium or potassium balances were typically those
with the highest BHI. That is, ORS had a positive sodium bal-
ance (Figure 4A), whereas orange juice and full-fat and skim-
med milk had positive potassium balances (Figure 4B).
DISCUSSION
Adequate hydration status may be associated with a de-
creased risk of a range of adverse outcomes, including urologic,
gastrointestinal, circulatory, and neurological disorders (14, 15).
In addition, maintenance of euhydration is important for the
preservation of physical and mental function (4, 5, 15, 16).
Consequently, identification of beverages that promote longer-
term fluid retention and maintenance of fluid balance for pro-
longed periods would be of real clinical and practical benefit in
situations in which free access to fluids is limited, or when
frequent breaks for urination are not desirable (25). In this
study we propose a novel tool to enable the objective assess-
ment of a beverages effectiveness to maintain hydration status
over a period of time after ingestion. The calculated BHI re-