Parot in
Parot in
Parotin®
Paroxetine
Description
Parotin® is a preparation of Paroxetine which is a potent and selective inhibitor of 5-
hydroxytryptamine (5-HT, serotonin) uptake. Paroxetine works by enhancing the
serotonergic activity in the central nervous system resulting from inhibition of neuronal
reuptake of serotonin (5-hydroxytryptamine, 5-HT), in addition with blocking the reuptake
of serotonin into human platelets and has only very weak effects on norepinephrine and
dopamine neuronal reuptake.
Adults
● Major depression, social anxiety disorder, post-traumatic stress disorder, generalized
anxiety disorder: The recommended dose is 20mg daily, usually to be taken in the morning
and maximum dose up to 50mg daily.
● Obsessive-compulsive disorder: The initial dose is 20mg daily, usually to be taken in the
morning and maximum dose up to 60mg daily.
● Panic disorder: The initial dose is 10mg daily, usually to be taken in the morning and
maximum dose up to 60mg daily.
Elderly
The maximum dose for elderly is 40mg daily.
Small amount of Paroxetine are excreted into breast milk and caution should be exercised
when Paroxetine is administered to a nursing woman. In published studies, as no sign of
drug effects were observed in infants, breast-feeding can be considered.
Side effects
The most common side effects are somnolence, insomnia, agitation, abnormal dreams
(including nightmares), increases in cholesterol levels, decreased appetite, dizziness,
tremor, headache, blurred vision, yawning, nausea, constipation, diarrhea, vomiting, dry
mouth, sweating, sexual dysfunction, asthenia, body weight gain.
The less common side effects are arrhythmias, confusion, urinary incontinence, panic
attacks, depersonalization, neuroleptic malignant syndrome-like events, peripheral edema,
acute glaucoma, hepatic disorders, priapism, tinnitus, extra pyramidal reactions and
withdrawal reactions.
Precautions
Paroxetine should be used with caution in patients with mania, epilepsy, seizures, bone
fracture, diabetes, ECT, glaucoma, cardiac conditions, hyponatraemia, haemorrhage,
renal/hepatic impairment.
Contraindications
Paroxetine is contraindicated in patients with a hypersensitivity to Paroxetine or any of the
exipients.
Drug interactions
Paroxetine should not be used with pimozide, tyrptophan, drug metabolizing enzyme
inducers /inhibitors, thioridazine, alcohol, fosamprenavir/ritonavir, MAOIs, lithium,
phenytoin/anticonvulsants, warfarin, drugs affecting gastric pH, NSAIDs and acetylsalicylic
acid.
Pharmaceutical precautions
Keep away from the reach of children. Store in a cool and dry place protected from light. To
be taken and sold only on the prescription of a registered physician.
Presentation
Parotin® 10 tablet: Each tablet contains Paroxetine 10mg as Hydrochloride Hemihydrate BP.
Parotin® 20 tablet: Each tablet contains Paroxetine 20mg as Hydrochloride Hemihydrate BP.
Packaging
Parotin® 10 tablet: Carton of 30 tablets in blister pack.
Parotin® 20 tablet: Carton of 30 tablets in blister pack.
ACI Limited
Narayanganj, Bangladesh