Hemorrhagic Bullous Dermatosis
Hemorrhagic Bullous Dermatosis
Hemorrhagic Bullous Dermatosis
Volume 16 Article 19
2015
Luis Eraso, MD
Thomas Jefferson University, [email protected]
Esteban Gnass, MD
Thomas Jefferson University, [email protected]
Geno Merli, MD
Thomas Jefferson University, [email protected]
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Govind, MD et al.: Hemorrhagic Bullous Dermatosis
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The Medicine Forum, Vol. 16 [2015], Art. 19
of continued bleeding into the hematoma. The bullae heparin therapy with no changes in dosing. Although the
started to regress approximately two weeks after onset, resolution of bullae in our patient occurred several days
eventually crusting over. The patient was eventually after enoxaparin dose reduction, it is hard to differentiate
discharged home. whether lesion regression occurred directly due to
medication management or the natural history of these
We present a case of hemorrhagic bullous dermatosis, seemingly benign, self-limiting, bullae.
which is a rare type of cutaneous reaction to heparins
with only a handful of cases reported in the literature.
Delayed-type (type IV) hypersensitivity and immune-
mediated (heparin-induced thrombocytopenia)
mechanisms are the most common causes of cutaneous References
complications attributed to heparin products.1 Type IV 1. Schindewolf M, Lindhoff-Last E, Ludwig RJ, Boehncke WH.
Heparin-induced skin lesions. Lancet. 2012; 380: 1867-79.
cutaneous hypersensitivity reactions are non-antibody
2. Ludwig, RJ, et al. Management of Cutaneous Type IV
mediated and typically occur several days to weeks
Hypersensitivity Reactions Induced by Heparin. Journal of
following drug exposure. They may manifest as isolated Thrombosis and Haemostasis. 2006; 96: 611-617.
or multiple erythematous plaques with papulovesicles 3. Hirsh, J., et al. Heparin and low-molecular-weight heparin
or scaling. Heparin-induced thrombocytopenia, on the mechanisms of action, pharmacokinetics, dosing, monitoring,
efficacy, and safety. Chest. 2001: 64S-94S.
other hand, can induce skin erythema that progresses
4. Villanueva CA, Najera L, Espinosa P, Borbujo J. Bullous
to hemorrhage and subsequent tissue necrosis.1 Several hemorrhagic dermatosis at distant sites: a report of 2 new cases
unusual and rare dermatologic manifestations have due to enoxaparin injection and a review of the literature. Actas
Dermosifiliograficas. 2012; 103(9): 816-819.
been reported in the literature with a broad differential
5. Maldonado Cid, Paola, et al. Bullous hemorrhagic dermatosis at
diagnosis including pustulosis, toxic epidermal
sites distant from subcutaneous injections of heparin: A report of
necrolysis, arthus reaction, baboon syndrome, hypere- 5 cases. Journal of the American Academy of Dermatology. 2012:
osinophilia, and calcinosis cutis.1,3 e220-e222.
6. Pena ZG, Suszko JW, Morrison LH. Hemorrhagic Bullae in a
73-year old man. JAMA Dermatology. 2013; 149(7): 871-872.
There have only been ten cases reported in the
7. Perrinaud A, Jacobi D, Machet MC, et al. Bullous hemorrhagic
literature regarding the clinical setting and course of dermatosis occurring at sites distant from subcutaneous injections
hemorrhagic bullosis. Mechanisms underlying the of heparin: three cases. J Am Acad Dermatol. 2006; 54: S5-7.
pathogenesis of these lesions have not been clearly 8. Choudry S., Fishman PM, Hernandez C. Heparin-induced bullous
hemorrhagic dermatosis. Cutis. 2013; 91(2): 93-98.
elucidated, although a hypersensitivity reaction has
been suspected.1,4,5 The histopathology of the bullae
reveal intraepidermal collections of red blood cells
without any thrombotic or vasculitic changes. Direct
immunofluorescence and heparin platelet factor 4 have
all been negative in prior case reports.4-7 Only one of
the ten cases has reported unfractionated heparin as
an inciting agent for hemorrhagic bullosis,8 while the
remaining have been from LMWH. The age range of
affected patients in case reports were 50-90 years old
with several having a history of malignancy.4-8