AST
AST
2. Hazards identification
Physical state : Solid.
OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard
(29 CFR 1910.1200).
Emergency overview : WARNING!
CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. MAY BE HARMFUL
IF SWALLOWED. CONTAINS MATERIAL THAT CAN CAUSE TARGET ORGAN
DAMAGE.
May be harmful if swallowed. Irritating to eyes, respiratory system and skin. Do not
ingest. Avoid contact with eyes, skin and clothing. Contains material that can cause
target organ damage. Use only with adequate ventilation. Keep container tightly closed
and sealed until ready for use. Wash thoroughly after handling.
Not available.
Routes of entry : Skin contact Eye contact. Inhalation.
Potential acute health effects
Inhalation : Irritating to respiratory system. Exposure to decomposition products may cause a health
hazard. Serious effects may be delayed following exposure.
Ingestion : Harmful if swallowed.
Skin : Irritating to skin.
Eyes : Irritating to eyes.
Potential chronic health effects
Chronic effects : Contains material that can cause target organ damage.
Carcinogenicity : No known significant effects or critical hazards.
Mutagenicity : No known significant effects or critical hazards.
Teratogenicity : No known significant effects or critical hazards.
Developmental effects : No known significant effects or critical hazards.
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2. Hazards identification
Fertility effects : No known significant effects or critical hazards.
Target organs : Contains material which causes damage to the following organs: mucous membranes.
Over-exposure signs/symptoms
Inhalation : Adverse symptoms may include the following:
respiratory tract irritation
coughing
Ingestion : No specific data.
Skin : Adverse symptoms may include the following:
irritation
redness
Eyes : Adverse symptoms may include the following:
pain or irritation
watering
redness
See toxicological information (section 11)
3. Composition/information on ingredients
United States
Name CAS number %
l-aspartic acid, disodium salt 5598-53-8 75
mannitol, d- 69-65-8 12
poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- 25322-68-3 5
3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-(3-chloro-2-propenyl)-,chloride, (z)- 51229-78-8 4
(Dowicil 200)
Canada
Name CAS number %
trometamol 77-86-1 21
Polyethylene glycol 135 25322-68-3 5
There are no additional ingredients present which, within the current knowledge of the supplier and in the
concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in
this section.
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5. Fire-fighting measures
Flammability of the product : No specific fire or explosion hazard.
Extinguishing media
In case of fire, use water spray (fog), foam or dry chemical.
Not suitable : None known.
Special exposure hazards : Promptly isolate the scene by removing all persons from the vicinity of the incident if
there is a fire. No action shall be taken involving any personal risk or without suitable
training.
Hazardous combustion : Decomposition products may include the following materials:
products carbon dioxide
carbon monoxide
nitrogen oxides
phosphorus oxides
halogenated compounds
metal oxide/oxides
Special protective : Fire-fighters should wear appropriate protective equipment and self-contained breathing
equipment for fire-fighters apparatus (SCBA) with a full face-piece operated in positive pressure mode.
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11 . Toxicological information
United States
Acute toxicity
Product/ingredient name Result Species Dose Exposure
trometamol LD50 Intravenous Rat 3.28 g/kg -
LD50 Intravenous Rat 1800 mg/kg -
TDLo Oral Rat 3000 mg/kg -
Chronic toxicity
Not available.
Carcinogenicity
Not available.
Mutagenicity
Not available.
Teratogenicity
Not available.
Reproductive toxicity
Not available.
Canada
Acute toxicity
Product/ingredient name Result Species Dose Exposure
trometamol LD50 Intravenous Rat 3.28 g/kg -
LD50 Intravenous Rat 1800 mg/kg -
TDLo Oral Rat 3000 mg/kg -
Chronic toxicity
Not available.
Carcinogenicity
Not available.
Mutagenicity
Not available.
Teratogenicity
Not available.
Reproductive toxicity
Not available.
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12 . Ecological information
Environmental effects : No known significant effects or critical hazards.
United States
Aquatic ecotoxicity
Product/ingredient name Test Result Species Exposure
Polyethylene glycol 135 - Acute LC50 Fish - Rainbow 96 hours
>20000000 ug/L trout,donaldson
Fresh water trout -
Oncorhynchus
mykiss - 25 to 50
g
- Acute LC50 Fish - Atlantic 96 hours
>1000000 ug/L salmon - Salmo
Fresh water salar - Parr - 8.2
to 11.7 cm - 5.1
to 14.1 g
Biodegradability
Not available.
Canada
Aquatic ecotoxicity
Product/ingredient name Test Result Species Exposure
Polyethylene glycol 135 - Acute LC50 Fish - Rainbow 96 hours
>20000000 ug/L trout,donaldson
Fresh water trout -
Oncorhynchus
mykiss - 25 to 50
g
- Acute LC50 Fish - Atlantic 96 hours
>1000000 ug/L salmon - Salmo
Fresh water salar - Parr - 8.2
to 11.7 cm - 5.1
to 14.1 g
Biodegradability
Not available.
13 . Disposal considerations
Waste disposal : The generation of waste should be avoided or minimized wherever possible. Empty
containers or liners may retain some product residues. This material and its container
must be disposed of in a safe way. Dispose of surplus and non-recyclable products via
a licensed waste disposal contractor. Disposal of this product, solutions and any by-
products should at all times comply with the requirements of environmental protection
and waste disposal legislation and any regional local authority requirements. Avoid
dispersal of spilled material and runoff and contact with soil, waterways, drains and
sewers.
Not available.
Disposal should be in accordance with applicable regional, national and local laws and regulations.
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees.
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14 . Transport information
International transport regulations
DOT Classification
UN number Not regulated.
Proper shipping -
name
Classes -
PG* -
Label
Additional - No additional remark.
information
TDG Classification
Mexico
Classification
UN number Not regulated.
Proper shipping -
name
Classes -
PG* -
Label
Additional -
information
IMDG Class
IATA-DGR Class
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14 . Transport information
Proper shipping -
name
Classes -
PG* -
Label
Additional -
information
15 . Regulatory information
United States
HCS Classification : Irritating material
Target organ effects
U.S. Federal regulations : TSCA 8(a) IUR: D-mannitol; Albumins, blood serum; Polyethylene glycol 135;
Dehydrogenase, lactate
United States inventory (TSCA 8b): Not determined.
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No
products were found.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean Air Act (CAA) 112 accidental release prevention: No products were found.
Clean Air Act (CAA) 112 regulated flammable substances: No products were found.
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
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15 . Regulatory information
State regulations : Connecticut Carcinogen Reporting: None of the components are listed.
Connecticut Hazardous Material Survey: None of the components are listed.
Florida substances: None of the components are listed.
Illinois Chemical Safety Act: None of the components are listed.
Illinois Toxic Substances Disclosure to Employee Act: None of the components are
listed.
Louisiana Reporting: None of the components are listed.
Louisiana Spill: None of the components are listed.
Massachusetts Spill: None of the components are listed.
Massachusetts Substances: None of the components are listed.
Michigan Critical Material: None of the components are listed.
Minnesota Hazardous Substances: None of the components are listed.
New Jersey Hazardous Substances: None of the components are listed.
New Jersey Spill: None of the components are listed.
New Jersey Toxic Catastrophe Prevention Act: None of the components are listed.
New York Acutely Hazardous Substances: None of the components are listed.
New York Toxic Chemical Release Reporting: None of the components are listed.
Pennsylvania RTK Hazardous Substances: None of the components are listed.
Rhode Island Hazardous Substances: None of the components are listed.
Canada
WHMIS (Canada) : Not a WHMIS controlled material.
Canadian lists : CEPA DSL: ; l-aspartic acid, disodium salt; 1,3-propanediol, 2-amino-2-(hydroxymethyl)-,
hydrochloride; 1,3-propanediol, 2-amino-2-(hydroxymethyl)-; mannitol, d-; poly(oxy-1,2-
ethanediyl), .alpha.-hydro-.omega.-hydroxy-; 3,5,7-triaza-1-
azoniatricyclo[3.3.1.13,7]decane, 1-(3-chloro-2-propenyl)-,chloride, (z)-
Canada inventory : Not determined.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations
and the MSDS contains all the information required by the Controlled Products Regulations.
16 . Other information
EU regulations
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16 . Other information
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
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