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Herczeg Diána Ildikó Szakdolgozat
Herczeg Diána Ildikó Szakdolgozat
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35
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36
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38
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1990 betegek DPHJYRQiVXWiQ
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2004 JRQGRODWRN UHODWtY NRFNi]DWD betegek, akik 4 N|]|WW D] |QJ\LONRVViJL KDMODP pYHVLGĘV]DNDODWW DQWLGHSUHVV]iQVKR]
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szedni x amitriptilin OR=0,83 CI=0,61-1,13
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milyen x paroxetin OR=1,29 CI= 0,97-1,7
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2001 SV]LFKRIDUPDNROyJLDLNH]HOpVWD] HON|YHWĘN |QJ\LONRVViJHOĘWWL
[48.] |QJ\LONRVViJHOĘWWD]RN, akik pYHVLGĘWDUWDP 30 napban
|QJ\LONRVViJRWN|YHWWHNHO alatt
4. M artinez |QJ\LONRVViJRNpV|QJ\LONRVViJL 10-pYHV eset kontroll x SSRI-k nem hordoznak nagyobb 146 095 WULFLNOXVRVDQWLGHSUHVV]iQV
2005 NtVpUOHWHN665,-WV]HGĘNN|]|WWD DQWLGHSUHVV]iQVW NRFNi]DWRWD7&$'-RNQiO DQWLGHSUHVV]iQVW
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V]HGĘNK|]NpSHVW OR=0,99 CI (95%)= 0,86-1,14
x KDOiORVNLPHQHWHOĦ|QJ\LONRVViJ
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48
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>@6HPPHOZHLV(J\HWHP3V]LFKLiWULDLpV3V]LFKRWHUiSLiV.OLQLND3V]LFKRWHUiSLiV
RV]WiO\http://semmelweis.hu/pszichoterapiasosztaly/2015/04/a-depresszio-tunetei-es-
kezelese/ PHJMHOHQtWYHMDQXiU
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[@5LKPHU=$GHSUHVV]LyNRUV]HUĦV]HPOpOHWH ± GLDJQRV]WLNDLpVWHUiSLiV
YRQDWNR]iVRN2UYRVWRYiEENpS]Ę6]HPOHNO|QV]iP-8
>@5LKPHU=)HNHWH66PHJL$gQJ\LONRVViJ
http://nol.hu/archivum/archiv-31945-20878 PHJMHOHQtWYHIHEUXiU
[7@0DJ\DU.iOPiQ6]|NĘeYD$QWLGHSUHVV]iQVpVDQWLPiQLiVYHJ\OHWHN*\LUHV
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[10.] 5LKPHU=3HVWDOLW\3$QWLGHSUHVV]tYXPRNpVKDQJXODWVWDELOL]iWRURN)UHGL-
1pPHWK$7DULVND3V]HUN$SV]LFKLiWULDPDJ\DUNp]LN|Q\YH0HGLFLQD
.|Q\YNLDGy-494
50
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WpQ\H]ĘN *\LUHV.OiUD)UVW=VX]VDQQDV]HUN$IDUPDNROyJLDDODSMDL0HGLFLQD
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*\yJ\V]HULQIRUPiFLy*\yJ\V]HUDGDWEi]LV
http://www.ogyei.gov.hu/gyogyszeradatbazis/ Aurorix 150 mg, 300 mg tabletta,
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About medication errors: http://www.nccmerp.org/about-medication-errors
PHJMHOHQtWYHM~OLXV
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ontent_000570.jsp PHJMHOHQtWYH 2015. M~OLXV
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[26@;&9W|UYpQ\D]HPEHULDONDOPD]iVUD NHUOĘJ\yJ\V]HUHNUĘOpVHJ\pE
J\yJ\V]HUSLDFRWV]DEiO\R]yW|UYpQ\HNPyGRVtWiViUyO
[29.] 0DJ\DU*\yJ\V]HUpV]L.DPDUD(OQ|NVpJLWiMpNR]WDWy7iMpNR]WDWyD
IDUPDNRYLJLODQFLDIRJDOPiUyOMRJLV]DEiO\R]iViUyOpVDJ\DNRUOyJ\yJ\V]HUpV]HN
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V]DNPDLIHODGDWDLUyOKWWSZZZPJ\NSPKXILOHVIDUPDNRYLJLODQFLD-taj-vegl.pdf
PHJMHOHQtWYHDXJXV]WXV
[30@2UV]iJRV*\yJ\V]HUpV]HWLpVeOHOPH]pV-HJpV]VpJJ\L,QWp]HW%HMHOHQWpV
IHOWpWHOH]HWWJ\yJ\V]HU-PHOOpNKDWiVRNUyO
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IHEUXiU
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EHMHOHQWpVH)RQWRVWiMpNR]WDWiVDPHOOpNKDWiV-EHMHOHQWpVUĘOpVDMHOHQWpVHN
pUWpNHOpVpQHNIRO\DPDWiUyO
http://www.ogyei.gov.hu/tajekoztatas_a_mellekhatas_jelentessel_kapcsolatban/
PHJMHOHQtWYHIHEUXiU
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*\yJ\V]HULQIRUPiFLy*\yJ\V]HUDGDWEi]LV
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[43@%RW]/$WXGRPiQ\RVEL]RQ\tWpNRNV]HUHSHDJ\yJ\tWiVEDQpVD
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DODSXOypUWpNHOpVpQHNJ\DNRUODWD3pFVL7XGRPiQ\HJ\HWHP-25
54
[45.] %RW]/%L]RQ\tWpNRNRQDODSXOyJ\yJ\V]HUpUWpNHOpVV]DNPDLpVJD]GDViJL
HOHP]pVpQHN~MLVPHUHWDQ\DJDL%RW]/V]HUN$J\yJ\V]HUWHUiSLDEL]RQ\tWpNRNRQpV
J\yJ\V]HUDGDWEi]LVRNRQDODSXOypUWpNHOpVpQHNJ\DNRUODWD3pFVL7XGRPiQ\HJ\HWHP
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56
0HOOpNOHWHN
.|V]|QHWQ\LOYiQtWiV
1. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Cardiovaszkuláris rendszer
orthosztatikus h!hullám EKG tachycardia. vezetési palpitatio arrythmia hypertonia hypotonia perifériás hypertenzív kardiális myocardiális extrasystole mellkasi értágulat vasculitis perifériás hematuria bradycardia ventrikuláris ventrikuláris vérzés purpura
Hatóanyag csoport Hatóanyag hypotonia kipirulás eltérések zavar vazospazmus krízis dekompenzáció infarktus fájdalom ischaemia fibrilláció tachycardia
imipramin """"" """"" """"" """"" """" """" """" "" "" ""
Tri és tetraciklusos amitriptylin """" """" """" """" """" "" """ ""
antidepresszánsok clomipramin """" """" """" """" " """" """ """
maprotilin """" """" """" " """" "" " " "
fluoxetin """" """" "" """ "" ""
fluvoxaim """ """" """" #
SSRI sertralin """" # """ # """" """ "" "" #
escitalopram # # """ # # ""
paroxetin """ """ """ """ ""
MAO-A gátlók moclobemid "" """"
venlafaxin """ """" """ """" """" # # # #
duloxetin """ """" """ """" """ """" """ ""
bupropion " """" """ " """" "
reboxetin """" """" """" """" """"
Egyéb antidepresszánsok
mianszerin # # #
mirtazapin """" """
trazodon # # # # # #
tianeptin """" """" """" """" !
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " !
2. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Pszichiátriai kórképek
hypomania álmosság rendellenes pszichózis emelkedett gondolkodási konverziós gyógyszer panaoid suicid
Hatóanyag csoport Hatóanyag delírium hallucináció dezorientáció agitatio nyugtalanság szorongás agresszió fáradékonyság álmatlanság alvászavar izgatottság fogcsikorgatás zavarodottság idegesség apathia pánikroham dadogás akathisia alvajárás
mania aluszékonyság álmok aktiválódás hangulat zavar zavar függ!ség téveszmék gondolatok
imipramin """" """" """" """" """" """" """" """" """" """" """ "" #
amitriptylin "" "" """ """ """ """" """ #
Tri és tetraciklusos antidepresszánsok
clomipramin """" """" """" """" """" """"" """" """" """"" """" """" """ #
maprotilin "" "" """" """" """" """" """" """" """" """" " "" "" #
fluoxetin "" "" """" """" """"" """" """" """" "" """ """ "" """" "" "" "" """
fluvoxamin """ "" """" """" """" """" """ """" #
SSRI sertralin """ """" """ """"" """" """" "" """ """" """" """ """ "" "" "" "" ""
escitalopram "" # """ """" """" "" """" """" """" """ """ """ """ #
paroxetin """ "" "" # """" """" """" """" """ "" "" #
MAO-A gátlók moclobemid """" """" """"" """" """/""
venlafaxin # """ "" """ # """" """" """ """" """" """ """ #
duloxetin "" """ "" """" "" """" """ """" """ """ """ """ """/""
bupropion " """" " """"" " """" """ " #
reboxetin # """" """" # """"" """" #
Egyéb antidepresszánsok
mianszerin # """" """" """" #
mirtazapin """ """ "" """" """ """" """ #
trazodon # # # # # # # # # # # # #
tianeptin # """" """" """" # """ # !
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " !
3. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Vérképz#szervi és nyirokrendszeri
abnormális aplasztikus
Hatóanyag csoport Hatóanyag agranulocytosis leukopenia thrombocytopenia eosinophylia lymphadenopathia anaemia granulocytopenia
vérzések anaemia
imipramin !! !! !! !!
amitriptylin !! !! !! !!
Tri és tetraciklusos antidepresszánsok
clomipramin ! ! ! ! !
maprotilin ! ! ! !
fluoxetin !!
fluvoxaim
SSRI sertralin " " !!
escitalopram "
paroxetin ! !!!
MAO-A gátlók moclobemid
venlafaxin " " "
duloxetin
bupropion " " "
reboxetin
Egyéb antidepresszánsok
mianszerin " "
mirtazapin " " " " "
trazodon " " " " "
tianeptin
!
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " !
! !
4. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Endokrin rendszer és szexuális funkció
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
! ! nem ismert " !
! !
5. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Anyagcsere változások
Hatóanyag csoport Hatóanyag testtömeg ! testtömeg " étvágy! étvágy" anorexia hyponatraemia hypercholesterinaemia hypoglycaemia hyperglycaemia
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " ! !
6. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Idegrendszeri tünetek
csökkent malignus
ízérzés epilepsziás pszichomotoros extrapiramidális serotonin egyensúly
Hatóanyag csoport Hatóanyag tremor paraesthesia fejfájás szédülés koncentráló memóriazavar fásultság convulsio ataxia myoclonus beszédzavar ájulás neuroleptikus.
zavara roham nyugtalanság tünetek syndroma zavar
képesség Szindróma
imipramin !!!!! !!!! !!!! !!!! !!! !! !! !! !!
amitriptylin !!!! !!!! !!!! !!!! !!!! !!!! !! !!!!
Tri és tetraciklusos antidepresszánsok
clomipramin !!!!! !!!! !!!!! !!!!! !!!! !!!! !!!! !!! !!! !!!!! !!!! !
maprotilin !!!!! !!!! !!!!! !!!!! !!!! ! !!!! !! ! !! !!!!! ! !
fluoxetin !!!! !!!!! !!!! !!!! !!!! !!!! !!! !!
fluvoxaim !!!! " !!!! !!!! " !! " !!! !!! " "
SSRI sertralin !!!! !!!! !!!!! !!!!! !!!! !!!! !!! !!! !!! !!!
escitalopram !!!! !!!! !!!!! !!!! !!! " " !! !! !!!
paroxetin !!!! !!!! !!!! !! !!! !
MAO-A gátlók moclobemid !!!! !!!!! !!!!!
venlafaxin !!!! !!!! !!!!! !!!!! !!! !! !!! " !!! " !!! !!! "
duloxetin !!!! !!!! !!!!! !!!! !!! !!! !!!! !! !! !! !!! !!
bupropion !!!! ! !!!!! !!!! !!!! !!!! ! !! ! !
reboxetin !!!! !!!! !!!!! !!!!
Egyéb antidepresszánsok
mianszerin " " "
mirtazapin !!!! !!! !!!!! !!!! !!!! " !!! !! " !!!
trazodon " " " " " " " " "
tianeptin !!!! !!!! !!!! " !
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " !
! !
7. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Anyagcsere változások
Hatóanyag csoport Hatóanyag testtömeg ! testtömeg " étvágy! étvágy" anorexia hyponatraemia hypercholesterinaemia hypoglycaemia hyperglycaemia
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " ! !
8. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Érzékszervek
akkomodációs emelkedett
Hatóanyag csoport Hatóanyag látászavar mydriasis fülzúgás glaucoma vertigo
zavar szembelnyomás
imipramin !!!!! !!!!! !! " !!
amitriptylin !!!! !!!! !!!! !!! !!!
Tri és tetraciklusos antidepresszánsok
clomipramin !!!!! !!!!! !!!! !!!! !
maprotilin !!!! !
fluoxetin !!!! !!! !!!
fluvoxaim " "
SSRI sertralin !!!! !!! !!
escitalopram !!! !!! !!!
paroxetin !!!! !!! " !
MAO-A gátlók moclobemid !!!
venlafaxin !!!! !!!! !!!! "
duloxetin !!!! !!! !!!! !! !!!
bupropion !!!! !!!!
reboxetin !!!! !!! !! " !!!
Egyéb antidepresszánsok
mianszerin
mirtazapin
trazodon
tianeptin !
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " ! !
9. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
Vese és húgyutak
vizelettartási
Hatóanyag csoport Hatóanyag vizeletretenció vizelési zavar nehézség/gyakori
vizeletürítés
imipramin !!!!
amitriptylin !!!
Tri és tetraciklusos antidepresszánsok
clomipramin ! !!!!!
maprotilin ! !!!!
fluoxetin !! !!! !!!!
fluvoxaim !
SSRI sertralin !!! !!
escitalopram "
paroxetin !!! !!!
MAO-A gátlók moclobemid
venlafaxin !!! !!!! !!
duloxetin !!! !!!!
bupropion !
reboxetin !!!! !!!!
Egyéb antidepresszánsok
mianszerin
mirtazapin "
trazodon
tianeptin !
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " ! !
10. számú melléklet
Mellékhatások
Antidepresszánsok mellékhatásai
B!r és b!r alatti szövetek
Jelmagyarázat
Nagyon gyakori 10 % ! !!!!!
gyakori 10%"# "1% !!!!
nem gyakori 1%" "0,1 % !!!
ritka 0,1%" "0,01 % !!
nagyon ritka 0,01 % > !
nem ismert " !