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Tonicity
Tonicity
6. The freezing point of a 5% solution of boric acid is -1.55°C. How many grams
of boric acid should be used in preparing 1000ml of an isotonic solution?
Answer:
The freezing point of isotonic solution should be -0.52°C
the concentration of boric acid needed to lower the freezing to -0.52 °C
Thus to make 1000ml
1.67% x 1000 = 16.77 g of boric acid
Answer:
E value of tetracaine Hydrochloride (E = 0.18). The prescription calls for 0.15 g
tetracaine Hydrochloride calculated as shown below
g Tetracaine Hydrochloride need to make 30 ml
Step1.
0.15 x 0.18 = 0.027 g of sodium chloride represented by tetracaine Hydrochloride
Step 2.
20 x 0.009 = 0.18 g of sodium chloride in 20 mL of an isotonic sodium chloride
solution
Step 3.
0.18 g (from Step 2) - 0.027 g (from Step 1) = 0.153g of sodium chloride
required to make the solution isotonic
But because the prescription calls for boric acid:
Step 4.
0.153 g ÷ 0.52 (sodium chloride equivalent of boric acid) = 0.294 g of boric acid
to be used