Quetiapine Drug Study
Quetiapine Drug Study
Quetiapine Drug Study
/ Effect
Action
Route
Generic Name: Therapeutic 150mg Schizophrenia Antagonizes Contraindicated Side Effects: Monitor mental status, onset of
PO Dopamine, in patients extrapyramidal symptoms.
Class: Frequent (19%-10%):
quetiapine serotonin, hypersensitive Assist with ambulation if dizziness occurs.
histamine, alpha1- to drug or its Headache Supervise suicidal-risk pt closely during early
Second- adrenergic ingredients. Drowsiness therapy (as psychosis, depression lessens,
Brand generation receptors. Avoid use when Dizziness energy level improves, increasing suicide
Name: (atypical) risk of torsades Occasional (9%-3%): potential).
Antipsychotic Therapeutic Effect: de pointes or Monitor B/P for hypotension, lipid profile,
Seroquel Diminishes sudden death Constipation blood glucose, CBC, or worsening
symptoms may be Orthostatic depression, unusual behavior.
associated with increased, hypotension Assess pulse for tachycardia (esp. with rapid
schizophrenia/bipol including in Tachycardia increase in dosage).
ar disorders. patients with a Dry mouth Monitor daily pattern of bowel activity,
history of Dyspepsia stool consistency.
cardiac Rash Assess for therapeutic response (improved
arrhythmias Asthenia thought content, increased ability to
such as Abdominal pain concentrate, improvement in self-care).
bradycardia, Rhinitis Eye exam to detect cataract formation
hypokalemia, or Rare (2%): should be obtained q6mos during
hypomagnesemi treatment.
a. Also avoid use Back pain
Patient/ family teaching
Fever
with other drugs Avoid exposure to extreme heat.
that prolong the Weight gain
Drink fluids often, esp. during physical
QTc interval and activity.
in patients with Take medication as ordered; do not stop
congenital Adverse Effects:
taking or increase dosage.
prolongation of CNS: Drowsiness generally subsides during
the QT interval.
Somnolence continued therapy.
Use cautiously in Avoid tasks that require alertness, motor
NMS (Neuroleptic
patients with malignant skills until response to drug is established.
increased risk of syndrome) Avoid alcohol.
QT-interval Seizures Slowly go from lying to standing.
prolongation, Hypertonia Report suicidal ideation, unusual changes in
such as those Dysarthria behavior.
with CV disease, Agitation
family history of Extrapyramidal
QT-interval reaction
prolongation, Fatigue
HF, or heart
CV:
hypertrophy,
and in elderly Palpitations
patients. Peripheral edema
Use cautiously in Hypotension
patients’ risk for HTN
falls, including Syncope
those with the
EENT:
diseases,
conditions, or Blurred vision
who are taking Ear pain
medications that Epistaxis
may cause Nasal congestion
somnolence, Pharyngitis
orthostatic Toothache
hypotension, or
GI:
motor or
sensory Nausea
instability. Anorexia
Use cautiously in Vomiting
patients with CV Gastroesophageal
disease, reflux
cerebrovascular GU:
disease,
conditions that UTI
predispose to Hematologic:
hypotension, a
Leukopenia
history of
Neutropenia
seizures or
Agranulocytosis
conditions that
lower the Metabolic:
seizure Hyperglycemia
threshold, and
conditions in Musculoskeletal:
which core body Myalgia
temperature Weakness
may be Tremor
elevated. Dyskinesia
Use cautiously in
patients at risk Respiratory:
for aspiration Increased cough
pneumonia. Dyspnea
Skin:
Rash
Diaphoresis
Acne
Other:
Flulike syndrome
pain