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Kollidon - The Original: Setting New Standards in Stability, Purity and Patient Safety
Kollidon - The Original: Setting New Standards in Stability, Purity and Patient Safety
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Bernhard Fussnegger,
an enabler in excipients
“I’ll be the first to admit it: I’m a perfectionist. So for me, producing best-
in-class PVP is simply not enough. We must also ensure that quality
remains consistently high. And the products need to be kept as stable
and pure as possible.”…
… says Bernhard Fussnegger, Senior Manager at BASF respon- world-class plant – plus most grades now feature our innovative
sible for all technical questions regarding povidone, copovidone aluminum-free PeroXealTM packaging concept that significantly
and crospovidone at the Global Marketing unit within Pharma reduces peroxide levels and virtually eliminates the risk of contam
Ingredients and Services. He understands that quality and stabil- ination with aluminum flakes. So you have peace of mind that your
ity are crucial for maximizing patient safety. That’s why Kollidon povidone is of excellent quality, and contains virtually no peroxide
is manufactured to the most exacting of quality standards in a – meaning you can even use it for oxygen-sensitive APIs.
Walter Reppe,
inventor of PVP
... and BASF registered the chemical’s first new standards in terms of stability, purity
pharmaceutical applications in the 1950s. and patient safety. The PeroXeal packaging
This makes us the most experienced team concept is our latest enhancement – and
in the industry. But we don’t rest on our thanks to perfectionists such as Bernhard
laurels. We continue to innovate to address Fussnegger, it’s sure not to be the last.
our customers’ emerging challenges, setting
The many faces of Kollidon®.
The broad Kollidon portfolio delivers The following pages highlight just a small selection of
tangible benefits: Kollidon products:
Peroxide [ppm]
tablets, and as a pore-former in taste-masking formulations – plus 250
it can improve bioavailability of certain poorly soluble actives. And
200
thanks to the new PeroXeal packaging concept that dramatically
150
reduces peroxide levels, Kollidon 30 can now be used for entirely
new applications. 100
50
0
01 3 6 9 12 18 24 36 40 48
Months
480
420
433
The Kollidon CL family is the industry’s widest portfolio of super 360
disintegrants and dissolution enhancers. These highly functional
300
cross-linked PVP polymers ensure that active ingredients are
Time [sec]
240
released from any solid dosage form at exceptionally high speed.
In addition, they improve bioavailability of certain poorly soluble 180
APIs. Kollidon CL is available as standard, fine, superfine and
120
micronized.
60 93 81
69
0
Without disintegrant Kollidon CL Kollidon CL-F Kollidon CL-SF
3
Kollidon 90 F Granulation efficiency and granule stability related to binder concentration
Fine Friability
100
90
Kollidon 90 F is the strongest wet-granulation binder on the 80
10000000
1000000
A copovidone with an exceptionally high binding capacity,
Viscosity [Pa*s]
Tablet, capsule, Suppositories, Ophthalmic, oral, Suspensions, Injectables CEP US-DMF Ph. Eur. USP/NF JP/JPE
granules, pellets, transdermal parenteral, topical syrups
oral lyophilizates systems, solutions
adhesive gels,
ultrasonic gels
Matrix polymer Kollidon VA 64 Soluble copovidone widely used for instant release formulation with hot-melt extrusion.
Kollidon SR Water-insoluble excipient formulation used as matrix in sustained release formulations by direct compression or hot-melt extrusion.
The finest grade of water-insoluble crospovidone disintegrant available in the market for small and oral disintegrating tablets.
Kollidon CL-SF *
It provides smooth tablet surface and strongly improves tablet hardness.
Thickener Kollidon 90 F * Soluble, high-molecular povidone with thickening properties to increase viscosity and adhesion.
The Kollidon® portfolio of various PVP grades sets new standards in quality,
purity and patient safety.
BASF’s experts are happy to answer all your questions. Simply send an email to
[email protected] or visit www.kollidon.com
03_140803e-01
Europe South America
BASF SE BASF South America Limited
Eftimios Tsituridis Fernanda Furlan
Phone: +49 621 60 76953 Phone: +55 11 3043 3658
Email: [email protected] Email: [email protected]
Disclaimer
The data contained in this publication are based on our current knowledge and experience. In view of the many factors
that may affect processing and application of our product, these data do not relieve processors from carrying out their
own investigations and tests; neither do these data imply any guarantee of certain properties, nor the suitability of the
product for a specific purpose. Any descriptions, drawings, photographs, data, proportions, weights etc. given herein may
change without prior information and do not constitute the agreed contractual quality of the product. It is the responsibil-
ity of the recipient of our products to ensure that any proprietary rights and existing laws and legislation are observed.
( 10/ 2014)
® = registered trademark of BASF SE