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Synopsis Submitted To: Application For The Registration of Subjects For Dissertation of The
Synopsis Submitted To: Application For The Registration of Subjects For Dissertation of The
Synopsis Submitted to
VINAYAKA MISSION’S RESEARCH FOUNDATION
(Deemed To Be University)
Degree of
DOCTOR OF MEDICINE
IN
HOMOEOPATHY
Organon of medicine and homoeopathic philosophy
Submitted By
DR.Y. ARAAFATH
1
VINAYAKA MISSION’S RESEARCH FOUNDATION
(DEEMED TO BE UNIVERSITY)
APPLICATION FOR THE REGISTRATION OF SUBJECTS FOR DISSERTATION
DR. Y. ARAAFATH
NAME OF THE CANDIDATE
AND ADDRESS DEPARTMENT OF ORGANON OF
MEDICINE & HOMOEOPATHIC
PHILOSOPHY.
1. VINAYAKA MISSION’S HOMOEOPATHIC
MEDICAL COLLEGE & HOSPITAL,
SALEM
Dr.Y. ARAAFATH
PERMANENT ADDRESS S/O A. YUSUFF AZAD
67, POONGANAGAR STREET, SARAMEDU
KARUMBUKADAI.
COIMBATORE-641008
“THE EFFICACY OF
HOMOEOPATHIC SIMILLIMUM IN
5. TITLE OF THE TOPIC
TREATINGATOPIC BRONCHIAL
ASTHMA WITH AN EVALUATION
BASED ON IgE”
6 BRIEF RESUME OF INTENDED WORK:
6.1 NEED FOR THIS STUDY:
Bronchial asthma is characterized by chronic airway inflammation and increased airway
responsiveness leading to symptoms of wheeze, cough and dyspnea. The prevalence of
asthma is increasing steadily.1
Asthma ranks amongst the most common chronic ailments of
the globe. It is estimated that 300 million people worldwide suffer from asthma.
Annually 250,000 deaths are attributed to asthma, and its complications.1
In our country, the disease is under recognized and
underrated. The WHO estimates that asthma contributes to the loss of 15 million
disability-adjusted life years.
The prevalence of asthma has increased markedly over the past 30 years. In developed
countries, approximately 10% of adults and 15% of children have asthma. The majority of
asthmatics have childhood onset of disease.
Asthma often starts early in life. The prevalence of asthma is
increasing in all age group, despite major advances in understanding the etiology and
pathophysiology of asthma and development of new therapeutic modalities to control
symptoms and prevent exacerbations, effective therapies are not widely used. 1
Homoeopathy has a vital role in the treatment of asthma. . Hence, I selected the topic
“EFFICACY OF HOMEOPATHIC SIMILLIMUM ON TREATING ATOPIC
BRONCHIALASTHMA WITH AN EVALUATION BASED ON IgE”.
6.2 AIMS AND OBJECTIVES
1.To study the efficacy of Homeopathic Medicines on treating atopic bronchialasthma.
2. To evaluate the serum IgE levels in bronchial asthmapatients.
REVIEW OF LITERATURE
6.3
DEFINITION
Asthma is a chronic inflammatory disorder of the airways that is
characterized by increased responsiveness of the tracheobronchial tree to a variety of
stimuli resulting in widespread spasmodic narrowing of the air passages which may
relieved spontaneously or by therapy. Asthma is an episodic disease manifested
clinically by paroxysms of dyspnea, cough and wheezing. However a severe and
unremitting form of the disease termed status asthmaticus.1
EPIDEMOLOGY
1. AGE: There is no age limit but majority of the cases are seen before the age of
25years.
2. HEREDITY: Asthma often runs in families and has got a hereditary
predisposition like migraine, epilepsy andhysteria.
3. CLIMATE: Better in dryclimate.
4. SEASON: Particular allergens may produce asthma in particularseason.
5. REFLUXES FROM THE NOSE AND NASOPHARYNX: Swelling of turbinate,
nasal polyp, adenoids and enlarged tonsils acts as abnormalrefluxes and predispose
toasthma.
6. INFECTION: Other diseases like chronic bronchitis and pulmonary tuberculosis
often predispose to asthma, hemolytic streptococci may actsimilar way.
7. EXCITING FACTORS: Sensation of animal hair and other dustparticles.2
TYPES
1. ATOPICASTHMA:
2. NON ATOPICASTHMA
CLASSIFICATIONS: -
1. Extrinsic Asthma
Early age usually begins inchildhood.
External allergens have a strongrole.
Early age usually begins inchildhood
External allergens have a strongrole.
Triggering factors are environmental allergens E.g.: dusts,
pollens,animals, dander andfoods.
Serum level immunoglobulin E(IgE) isincreased.
Skin hypersensitivity test to common inhalant allergens ispositive.
Response to provocation tests ispositive.2
2. Intrinsic Asthma:
Onset is usually after 30 years ofage.
There are no precipitating causes or raised antibodylevels.
The patients show a higher frequency of eosinophilia, aspirinsensitivity.
Respiratory infections due to viruses E.g.; rhinovirus, para influenzavirus
Inhaled air pollutants E.g.: smoke,fumes.2
3. MIXEDTYPE
Patients have mixed features ofboth.
These patients who develop asthma in early life have strong allergic
component, while those who develop the disease late tend to benon-allergic.3
CLINICAL FEATURES; -
B. SIGNS:
Wheezing
Bluish discoloration of lips andface.
Rapidpulse
Expansion of chest is considerably diminished (less than2cm)2
INVESTIGATIONS
1.SERUMIgE:
Increased serum level of total or allergen – specific IgE
(RADIOALLERGOSORBENT TEST- RAST) may be helpful mainly in atopic
asthma.5
2. BLOOD
Increase in number of eosinophils in peripheral blood (>0.4 * 10 IL) ESR
increased when associated with infection.
4.PULMONARY FUNCTIONTEST:
Measurement of the FEV1/VC ratio or PEF provides a fairly reliable indication
of the degree of airflow obstruction.
i. FEV1 (forced expiratory volume in 1 second) –Low
ii. Vc (vital capacity) –Low
iii. FEV1/VC - Low
iv. PEF (Peak Expiratory flow rate) – Serial recordings are useful in diagnosis.
There is usually a marked diurnal variation in PEF. The lowest values being
recorded in the morning (morning dipping). Measurement of Bronchial
reactivity by administering increasing concentrations of substances such as
histamine and meta choline by inhalation until there is a 20% fall. This
concentration is called the PC20 and patients with asthma show evidence of
bronchoconstriction at much lowerconcentrations.
v. LungVolumes:
TLC- Total lung capacity –High
RV – Residual volume –High.5
5.SPUTUM:
Increased eosinophils, curschmann’s spirals or creola bodies, Charcot -Leyden
Crystals. Estimation of eosinophilic cationic protein for assessment of severity.6
6. EXERCISE CHALLENGETEST:
The use of exercise test is useful when the symptoms are predominantly related to
exercise. E.g.: six-minute exercise test but a negative test does not rule out asthma.4
MANAGEMENT OF ASTHMA
HOMOEOPATHIC APPROACH
Homoeopathy does not seek merely to palliate or to suppress but it goes to
the grass root of trouble and thus it does not give temporarily relief but instead it
restores the ‘whole sick to health permanently and judiciously.
Stuart close says “Homoeopathy does not treat disease. It treats patients.
“In one word, it individualizes. Homoeopathy recognizes the individuality of each drug
and substance in nature. Homeopathy recognizes the individuality of each patient or
case.7
H.A. Robert says, Homeopathic law of cure is ‘similiasimilibuscurentur’
Potentized medicine, administered according to the law of similia is the true regulator
of vital energy.8
7.1
MATERIALS:
Source of Data:
Patient will be collected from the OPD/IPD. Peripheral health centers of Vinayaka
Mission’s Homeopathic Medical college and Hospital, Salem and medical camps
conducted by college.
Case Proforma:
Pre designed homoeopathic case sheet.
Diagnostic Criteria:
Detailed case history will be taken as per proforma. Proper clinical examination of
patient will be done. Measurement of Serum IgEwill be done on all patients.
IgE- IMMUNOGLOBULIN E
Immunoglobulin E (IgE) is one of the body’s 5 classes (isotypes) of immunoglobulins
(antibodies). This immunoglobulin was discovered in 1966 by ishizaka during
investigation of atopic regain antibodies
Measurement of serum IgE is often used as a tool in the diagnosis and
management of atopic diseases, such as asthma. It has been used to distinguish atopic
from non-atopic individuals presenting allergy like symptoms.
Prognostic criteria
7. METHODS:
2 Research design
A prospective clinical study design without controlgroup.
Sampledesign
Purposive sampling done as per inclusion and exclusioncriteria.
Sample size will be minimum 30 innumber
Inclusion Criteria
Patients were selected from all agegroups
Bothsexes
Patients having recurrent asthmatic attack and allergic reactions (atopic
dermatitis, allergicrhinitis)
Patients with strong family history of allergy andasthma.
Exclusion Criteria
Patients suffering from other respiratory diseases.
Patients suffering with other systemicdiseases.
Data collection:
Primary and secondary data will be collected will be collected through a pre-designed
case sheet.
LIST OF REFRENCES
2. Krishna Das KV. Textbook of Medicine. 6th ed. Jaypee Brothers Medical; 2017;.1018-
1019pp
4. Ralston SH, Penman ID, Strachan MWJ, Hobson R, eds. Davidson’s Principles
and Practice of Medicine. Volume 1. 23rd ed. Elsevier Health Sciences;
2018.569pp
6. Munjal YP, Sharm SK. API Textbook of Medicine, Ninth Edition, Volume
1 . Jaypee Brothers Medical; 2012. 1706 -1707pp
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