Who
Who
Classification of Pesticides
by Hazard
and
Guidelines to Classification
2009
WHO Library Cataloguing-in-Publication Data
The designations employed and the presentation of the material in this publication do not imply the
expression of any opinion whatsoever on the part of the World Health Organization concerning the
legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its
frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may
not yet be full agreement.
The mention of specific companies or of certain manufacturers’ products does not imply that they
are endorsed or recommended by the World Health Organization in preference to others of a similar
nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are
distinguished by initial capital letters.
All reasonable precautions have been taken by the World Health Organization to verify the information
contained in this publication. However, the published material is being distributed without warranty of
any kind, either expressed or implied. The responsibility for the interpretation and use of the material
lies with the reader. In no event shall the World Health Organization be liable for damages arising from
its use.
Up until the present revision the original guidelines approved by the World Health Assembly
in 1975 have been followed without amendment. In December, 2002 the United Nations
Committee of Experts on the Transport of Dangerous Goods and on the Globally Harmonized
System of Classification and Labelling of Chemicals (UNCETDG/GHS) approved a document
called “The Globally Harmonized System of Classification and Labelling of Chemicals”
with the intent to provide a globally-harmonized system1 (GHS) to address classification of
chemicals, labels, and safety data sheets. The GHS (with subsequent revisions) is now being
widely used for the classification and labeling of chemicals worldwide. For this revision of
the Classification the WHO Hazard Classes have been aligned in an appropriate way with
the GHS Acute Toxicity Hazard Categories for acute oral or dermal toxicity as the starting
point for allocating pesticides to a WHO Hazard Class (with adjustments for individual
pesticides where required). It is anticipated that few of the more toxic pesticides will change
WHO Hazard Class as a result of this change. As has always been the case, the classification
of some pesticides has been adjusted to take account of severe hazards to health other than
acute toxicity (as described in Part II). The GHS Acute Toxicity Hazard Category for each
pesticide is now presented alongside the existing information.
Part II: Guidelines to Classification. Individual products are classified in a series of tables,
according to the oral or dermal toxicity of the technical product. The tables are subject to
review periodically.
The toxicity values are intended to be a guide only. Formulations should be separately
classified using the methods set out on pages 4 (single technical product) and 7 (mixtures)
and the table in Part I. To assist in the classification of formulations, an annex is provided
giving numerical tables from which the classification may also be derived.
1
See http://www.unece.org/trans/danger/publi/ghs/ghs_rev03/03files_e.html.
1
Comments on Part II of the document are welcome, together with proposals for new entries.
These should be addressed to the International Programme on Chemical Safety, World
Health Organization, 1211 Geneva 27, Switzerland, and should include supporting data on
the compound being commented on or proposed.
2
PART I
RECOMMENDED CLASSIFICATION OF PESTICIDES BY HAZARD
The text below is reproduced from the Proposal2 which was adopted by the World Health
Assembly in 1975.
The hazard referred to in this Recommendation is the acute risk to health (that is, the risk of
single or multiple exposures over a relatively short period of time) that might be encountered
accidentally by any person handling the product in accordance with the directions for handling
by the manufacturer or in accordance with the rules laid down for storage and transportation
by competent international bodies.
Any classification based on biological data can never be treated as final. In the assessment
of biological data, honest differences of opinion are inevitable and most borderline cases
can be reclassified in an adjacent class. Variability or inconsistency in toxicity data due to
differences in susceptibility of test animals, or to experimental techniques and materials used
can also result in differing assessments. The classification criteria are guide-points intended
to supplement but never to substitute for special knowledge, sound clinical judgement or
experience with a compound. Reappraisal might be necessary from time to time.
Basis of classification
The classification distinguishes between the more and the less hazardous forms of each
pesticide in that it is based on the toxicity of the technical compound and on its formulations. [In
particular, allowance is made for the lesser hazards from solids as compared with liquids.]3
The classification is based primarily on the acute oral and dermal toxicity to the rat since
these determinations are standard procedures in toxicology. Where the dermal LD504 value
of a compound is such that it would place it in a more restrictive class than the oral LD50
value would indicate, the compound will always be classified in the more restrictive class.
Provision is made for the classification of a particular compound to be adjusted if, for any
reason, the acute hazard to man differs from that indicated by LD50 assessments alone.
2
Official Record of the World Health Organization 1975, No.223, Part 1, p.12
3
Note:- this distinction is not made in the GHS and no longer applies to the WHO Classification
4
The LD50 value is a statistical estimate of the number of mg of toxicant per kg of bodyweight required to kill
50% of a large population of test animals.
3
Application of the criteria for classification
(a) Where it is shown that for a particular compound the rat is not the most suitable test
animal (for example, if another species is conspicuously more sensitive or more
closely resembles man in its reaction) then the classification of that compound
should take this into account.
(b) In practice, the majority of classifications will be made on the acute oral LD50
value. However, dermal toxicity must always be considered since it has been found
that, under most conditions of handling pesticides, a high proportion of the total
exposure is dermal. Classification based on dermal data in a class indicating a great
risk is necessary when the dermal LD50 values indicate greater hazard than oral
LD50 values.
(c) If the active ingredient produces irreversible damage to vital organs, is highly
volatile, is markedly cumulative in its effect, or is found after direct observations
to be particularly hazardous or significantly allergenic to man, then adjustments to
the classification can be made by classifying the compound in a class indicating a
higher hazard. Alternatively, if it can be shown that the preparation is less toxic or
hazardous than expected from consideration of the LD50 values of the ingredient or
ingredients, or for any other reason, adjustments should be made by classifying the
compound in a class indicating a lower hazard.
(d) In certain special cases the acute oral or dermal LD50 values of the compound or
formulation should not be used as the main basis for classification. In such cases
(for example, aerosol preparations, other special formulations and fumigants), more
appropriate criteria should be used.
(e) It is highly desirable that, whenever practicable, toxicological data for each formulation
to be classified should be available from the manufacturer. However, if such data are
not obtainable, then the classification may be based on proportionate calculations from
the LD50 values of the technical ingredient or ingredients, according to the following
formula:
If the formulation contains more than one ingredient (including solvents, wetting
agents, etc.) of significant toxicity-enhancing properties, then the classification
should correspond to the toxicity of the mixed ingredients.
(f) With a few exceptions, pesticides have low volatility and therefore no criteria are
at present set out for volatility in this Recommendation. The inclusion of such
criteria is unlikely to affect the classification of pesticides by hazard except in
the case of volatile fumigants used in agriculture and food storage. On the other
hand, when the criteria are applied to pesticide formulations based on solvents or
to other chemicals, account must be taken of volatility and consequent inhalation
toxicity.
4
Effects of classification on labeling5
While no specific symbols to identify classes are included in the Recommendation, the
following are the general implications of the classification as regards labelling.
The aim should be uniformity in the statement on the nature of the risk (by phrase and/or
symbol) on the label of the product, irrespective of the country of origin or use. Labels of
products classified in classes Ia and Ib should bear a symbol indicating a high degree of
hazard (usually a type of skull and crossbones) and a signal word or phrase, e.g. POISON
or TOXIC. The presentation of the symbol and word or phrase, in terms of colour, size and
shape should ensure that they are given sufficient prominence on the label.
The text should be in the local language and for all formulations should include the approved
name of the active ingredient or ingredients, the method of use, and precautions to be taken
in use. For classes Ia and Ib, symptoms and immediate treatment of poisoning should also
be included.
The detailed precautions necessary for the use of a pesticide depend on the nature of the
formulation and the pattern of use and are best decided by a pesticide registration authority
when accepting a commercial label.
There are international agreements on symbols to denote hazards from materials which
are inflammable, corrosive, explosive, etc., and these should be consulted and used where
appropriate.
Revised criteria for classification (introduced for 2009 update)
The table showing the Recommended Criteria for Classification from the original World
Health Assembly Proposal is not shown because it is no longer used. WHO now uses the
Acute Toxicity Hazard Categories from the GHS6 as the starting point for classification. This
change is consistent with the 1975 World Health Assembly Resolution which envisaged
that the WHO Classification would be further developed with time in consultation with
countries, international agencies and regional bodies. The GHS meets this requirement as a
classification system with global acceptance following extensive international consultation.
Oral Dermal
Ia Extremely hazardous <5 < 50
Ib Highly hazardous 5–50 50–200
II Moderately hazardous 50–2000 200–2000
III Slightly hazardous Over 2000 Over 2000
U Unlikely to present acute hazard 5000 or higher
Details of how the WHO Classification has been aligned with the GHS Acute Toxicity
Hazard Categories are presented in Part II.
5
ee International Code of Conduct on the Distribution and Use of Pesticides, FAO (2003), available at
S
http://www.fao.org/docrep/005/Y4544E/y4544e00.HTM; also Guidelines on Good Labelling Practice for
Pesticides, FAO (1995), available at http://www.fao.org/ag/AGP/AGPP/Pesticid/Code/Download/label.pdf
6
See http://www.unece.org/trans/danger/publi/ghs/ghs_rev03/03files_e.html. The categories for oral and
dermal routes are used.
5
PART II
GUIDELINES TO CLASSIFICATION OF PESTICIDES BY HAZARD
The main section of the guidelines consists of five tables preceded by notes on their use. In
the tables, active ingredients (technical grade) have been classified as follows:
6
NOTES ON THE USE OF THE TABLES IN CLASSIFICATION
1. While the classification deals only with the acute risk to health, evaluations of other
effects, including cancer, have been completed for many compounds for registration
purposes. Where other effects have been shown to occur in man, these are noted in the
‘Remarks’ column and may have in some cases resulted in an adjusted classification.
2. Wherever possible, the data are listed under internationally approved common names,
or if such names are not at present available, under nationally approved names. Some
other common names appear in the alphabetic index pp. 65-78. Trade names are not
given since there are many of these.
3. A list of references that may be used for the identification of pesticides is given at the
end of these introductory notes, and the manufacturer should always assist by specifying
any existing approved or common names for his product.
4. It is not possible to include classification of mixtures of pesticides in the guidelines: very
many of these are marketed with varying concentrations of active constituents. There
are three possible approaches to the classification of mixtures - in order of preference:
(a) require the formulator to obtain reliable acute oral and dermal toxicity data for rats
on the actual mixture as marketed: or
(b) classify the formulation according to the most hazardous constituent of the mixture
as if that constituent was present in the same concentration as the total concentration
of all active constituents: or
(c) apply the formula:
Ca Cb Cz 100
+ + … ≡
Ta Tb Tz Tm
The formula can also be used for dermal toxicities provided that this information is
available on the same species for all constituents. The use of this formula does not take
into account any potentiation or protective phenomena.
7
5. In the tables below, single figures have been given as LD50 values for classification
purposes, using the route as described in the table. Where several LD50 values have
been published, the lowest deemed reliable is used. Where a sex difference occurs in
LD50 values, the value for the more sensitive sex is used. A number of adjustments to
Classification have been made in respect of some pesticides and these are explained. A
borderline case has been classified in the more or less hazardous class after consideration
of its toxicology and use experience.
6. In the former WHO Classification scheme pesticides were classified on the basis of the
physical state of the technical product. A distinction between liquids and solids is no longer
made.
7. In Table 5, a number of pesticides are listed as unlikely to present any acute hazard in
normal use. The WHO classification is open-ended but it is clear that there must be a point
at which the acute hazard posed by the use of these compounds is so low as to be negligible
provided that the precautions are taken that should be used in dealing with any chemical.
In compiling this table, it has been assumed that this point is an LD50 of 5000 mg/kg bw
or greater (in line with the upper limit for classification in the GHS). However, it should
not be overlooked that in formulations of these technical products, solvents or vehicles
may present a greater hazard than the actual pesticide and therefore classification of a
formulation in one of the higher hazard classes may be necessary.
8. The WHO Classification is not limited to chemical pesticides. Biological pesticides can
also be included if a suitable evaluation is available (Bacillus thuringiensis is included
based on Environmental Health Criteria Document 217).
9. The toxicity data for pyrethroids is highly variable according to isomer ratios, the vehicle
used for oral administration, and the husbandry of the test animals e.g. fasting prior to
dosing. The variability is reflected in the prefix ‘c’ before LD50 values. The single LD50
value chosen for classification purposes is generally based on administration in corn
oil and can be much lower than that in aqueous solutions. This underlines the need for
classification by formulation if the classification is to reflect true hazard.
Column 1: Common name. [ISO] denotes common name of the active ingredient approved
by the International Organization for Standardization. Such names are, when available,
preferred by WHO to all other common names. However, attention is drawn to the fact that
some of these names may not be acceptable for national use in some countries. If the letters
ISO appear within parentheses (ISO), this indicates that ISO has standardized (or is in the
process of standardizing) the name of the base, but not the name of the derivative listed in
column 1. For example, fentin acetate (ISO) indicates that fentin is an ISO name, but fentin
acetate is not. ISO* denotes pending ISO approval of the name. C denotes chemical, trivial,
or other common name.
Column 2: CAS Registry number: The number for the chemical, not those for e.g. different
esters or salts are given.
8
Column 3: UN number refers to the UN Recommendations on the transport of dangerous
goods, Eleventh revision (1999). This is given only for active ingredients in Tables 1, 2, 3
or 4, since so few ingredients in Table 5 have UN numbers. The UN number refers only to the
active ingredient; formulations are likely to have different numbers, since the ingredient may,
for example, be dissolved in a solvent - and liquid products have different UN numbers, which
depends on their flammability.
Column 4: Chemical type. Only a limited number of chemical types are shown. Most have
some significance in the sense that they may have a common antidote, or may be confused in
the nomenclature with other chemical types e.g. thiocarbamates are not cholinesterase inhibitors
and do not have the same effects as carbamates. Chemical type is also a determinant of the UN
numbering system. These chemical classifications are included only for convenience, and do
not represent a recommendation on the part of the World Health Organization as to the way
in which the pesticides should be classified. It should, furthermore, be understood that some
pesticides may fall into more than one type.
Column 5: Physical state. Refers only to the active ingredient. L denotes liquid, including
solids with a melting point below 50oC; oil denotes oily liquids and S solids, including waxes.
The physical state may affect the exposure potential, and thus the absorbed amount of the
chemical, and was taken into account when determining classification under the previous
scheme.
Column 6: Main use. In most cases only a single use is given. This is only for identification
purposes and does not exclude other uses.
AC acaricide L larvicide
AP aphicide M molluscicide
B bacteriostat (soil) MT miticide
FM fumigant N nematocide
F fungicide, other than for seed O other use for plant pathogens
treatment PGR plant growth regulator
FST fungicide, for seed treatment R rodenticide
H herbicide RP( ) repellant (species)
I insecticide -S applied to soil: not used with herbicides
IGR insect growth regulator or plant growth regulators
Ix ixodicide (for tick control) SY synergist
9
Column 7: GHS: This column indicates the classification of the pesticide according to
“The Globally Harmonized System of Classification and Labelling of Chemicals” (GHS)7.
The value shown in the column is the Acute Toxic Hazard Category according to the GHS
criteria, which in turn is derived from the acute toxicity estimate value for the substance.
In the majority of cases the acute toxicity estimate will be the experimentally-derived LD50
value for oral exposure. A comparison of the criteria (as LD50 values) used for the different
classes in the former WHO Scheme or for GHS categories is shown in the tables below. The
GHS table shows only a simplified summary; for full details of classification according to
GHS the official publication of the GHS should be consulted.
Oral Dermal
Solids Liquids Solids Liquids
Ia Extremely hazardous 5 or less 20 or less 10 or less 40 or less
Ib Highly hazardous 5 - 50 20 - 200 10-100 40 – 400
II Moderately hazardous 50 - 500 200 - 2000 100-1000 400 – 4000
III Slightly hazardous Over 500 Over 2000 Over 1000 Over 4000
GHS Classification
Oral Dermal
LD50 a
Hazard LD 50
b
Hazard Statement
(mg/kg bw) Statement (mg/kg bw)
Fatal if Fatal in contact
Category 1 <5 < 50
swallowed with skin
Fatal if Fatal in contact
Category 2 5 - 50 50 - 200
swallowed with skin
Toxic if Toxic in contact
Category 3 50 - 300 200 - 1000
swallowed with skin
Harmful if Harmful in contact
Category 4 300 - 2000 1000 - 2000
swallowed with skin
May be harmful May be harmful in
Category 5 2000 - 5000 2000 - 5000
if swallowed contact with skin
a
For oral data the rat is the preferred species, though data from other species may be appropriate when
scientifically justified
b
For dermal data the rat or rabbit are the preferred species, though data from other species may be appropriate
when scientifically justified
7
See http://www.unece.org/trans/danger/publi/ghs/ghs_rev03/03files_e.html. The categories for oral and
dermal routes are used
10
The former WHO Classification scheme applied different criteria to liquids and solids,
but the GHS does not make a similar distinction and applies the same criteria. The GHS
cut-off values for Category 2 and Category 3 are lower than the values which applied to
liquids under the former WHO scheme, such that some liquids allocated to Class Ib would
be placed in the lower GHS Category 3 (specifically pesticides with oral LD50 values in the
range 50‑200 mg/kg bw). In aligning the WHO scheme with the GHS criteria there was no
intention to “lower” the classification of pesticides previously considered to be “Highly
hazardous”. Therefore, the classification of this limited number of liquid pesticides has been
adjusted such that they remain in Class Ib. The revised criteria for the WHO classification
scheme are shown in Part I (page 5).
Column 8: LD50. The LD50 value is a statistical estimate of the number of mg of toxicant per
kg of body weight required to kill 50% of a large population of test animals: the rat is used
unless otherwise stated. Usually a single value, but sometimes a range is given. “c” preceding
the value indicates that it is a value within a wider than usual range, adopted for classification
purposes. When several different values are reported in the literature, the lowest is reported and
used as the basis of classification, unless there are clear indications that a higher value is more
reliable. Oral route values are used unless the dermal route values place the compound in a
more hazardous class, or unless the dermal values are significantly lower than the oral values,
although in the same class. Dermal LD50 values are indicated with the letter D.
Column 9: Remarks. This column is used to indicate cases in which the classification of a
technical product has been adjusted (i.e., the oral LD50 value is not directly used as the basis
of classification); Major irritant properties are also noted although they do not affect the
classification. Sources of further information may also be given here: DS denotes a WHO/
FAO Data Sheet on Pesticides, EHC an Environmental Health Criteria monograph, HSG a
Health and Safety Guide, IARC IARC Monographs on the Evaluation of Carcinogenic Risks
to Humans, ICSC an International Chemical Safety Card, JMPR an evaluation by the Joint
FAO/WHO Meeting on Pesticide Residues and JECFA an evaluation by the the Joint FAO/
WHO Expert Committee on Food Additives. These publications (with the exception of IARC
Monographs) can be found on the IPCS web site (http://www.who.int/ipcs/).
11
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13
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18
Table 1. Extremely hazardous (Class Ia) technical grade active ingredients in pesticides
Aldicarb [ISO] 116-06-3 2757 C S I-S 1 0.93 DS 53; EHC 121; HSG 64; IARC 53; ICSC 94; JMPR 1993, 1996a
Brodifacoum [ISO] 56073-10-0 3027 CO S R 1 0.3 DS 57; EHC 175; HSG 93
Bromadiolone [ISO] 28772-56-7 3027 CO S R 1 1.12 DS 88; EHC 175; HSG 94
Bromethalin [ISO] 63333-35-7 2588 S R 1 2
Calcium cyanide [C] 592-01-8 1575 S FM 2 39 Adjusted classification; see note 1; ICSC 407
Captafol [ISO] 2425-06-1 S F 5 5000 Adjusted classification; see note 2; HSG 49; IARC 53; ICSC 119;
JMPR 1978, 1986a; see note 3
Chlorethoxyfos [ISO] 54593-83-8 3018 OP L I 1 1.8 Extremely hazardous by skin contact (LD50 = 12.5 mg/kg); ICSC 1681
Chlormephos [ISO] 24934-91-6 3018 OP L I 2 7 ICSC 1682
Chlorophacinone [ISO] 3691-35-8 2588 S R 1 3.1 DS 62; EHC 175
19
Difenacoum [ISO] 56073-07-5 3027 CO S R 1 1.8 EHC 175; HSG 95
Difethialone [ISO] 104653-34-1 2588 S R 1 0.56 EHC 175
Diphacinone [ISO] 82-66-6 2588 S R 1 2.3 EHC 175
Disulfoton [ISO] 298-04-4 3018 OP L I 1 2.6 DS 68; JMPR 1992, 1997a; ICSC 1408
EPN 2104-64-5 2783 OP S I 2 14 See note 4; ICSC 753
Ethoprophos [ISO] 13194-48-4 3018 OP L I-S 2 D26 DS 70; JMPR 2000; ICSC 1660; [Oral LD50 = 33 mg/kg]
Flocoumafen 90035-08-8 3027 S R 1 0.25 EHC 175; ICSC 1267
Hexachlorobenzene [ISO] 118-74-1 2729 OC S FST 5 D10000 Adjusted classification (notes 3 and 5); IARC 79; ICSC 895; EHC 195
Mercuric chloride [ISO] 7487-94-7 1624 HG S F-S 1 1 See note 3; ICSC 979
Mevinphos [ISO] 26718-65-0 3018 OP L I 1 D4 DS 14; ICSC 924; JMPR 1998b; [Oral LD50 = 3.7 mg/kg]
Parathion [ISO] 56-38-2 3018 OP L I 2 13 See note 3; DS 6; HSG 74; IARC 30, Suppl. 7; ICSC 6; JMPR 1996b
Parathion-methyl [ISO] 298-00-0 3018 OP L I 2 14 See note 3; DS 7; EHC 145; HSG 75; ICSC 626; JMPR 1985c, 1996b
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
Phenylmercury acetate [ISO] 62-38-4 1674 HG S FST 2 24 Adjusted classification; see notes 3 and 6; ICSC 540
Phorate [ISO] 298-02-2 3018 OP L I 1 2 DS 75; JMPR 1997b, 2005; ICSC 1060
Phosphamidon 13171-21-6 3018 OP L I 2 7 See note 3; DS 74; ICSC 189; JMPR 1987b
CAS Nos for E and Z isomers 297-99-4 and 23783-98-4
Sodium fluoroacetate [C] 62-74-8 2629 S R 1 0.2 DS 16; ICSC 484
Sulfotep [ISO] 3689-24-5 1704 OP L I 1 5 ICSC 985
Tebupirimfos [ISO*] 96182-53-5 3018 OP L I 1 1.3 Extremely hazardous by skin contact (LD50 9.4 mg/kg in rats)
Terbufos [ISO] 13071-79-9 3018 OP L I-S 1 c2 JMPR 1991, 2004
EHC = Environmental Health Criteria Monograph; DS = Pesticide Data Sheet; HSG = Health and Safety Guide; IARC = IARC Monographs on the Evaluation of
Carcinogenic Risks to Humans; ICSC = International Chemical Safety Card; JMPR = Evaluation by the Joint FAO/WHO Meeting on Pesticide Residues.
Notes to Class Ia
20
1. Calcium cyanide is in Class Ia as it reacts with moisture to produce hydrogen cyanide gas. The gas is not classified under the WHO system (see Table 8).
2. Captafol is carcinogenic in both rats and mice.
3. The international trade of captafol, hexachlorobenzene, mercury compounds, parathion, parathion-methyl, and phosphamidon is regulated by the Rotterdam convention
on Prior Informed Consent (see http://www.pic.int/), which entered into force on 24 February 2004. See Table 7, p. 51
4. EPN has been reported as causing delayed neurotoxicity in hens.
5. Hexachlorobenzene has caused a serious outbreak of porphyria in humans. The use and production of hexachlorobenzene is severely restricted by the Stockholm
convention on persistent organic pollutants, which entered into force on 17 May, 2004. See http://www.pops.int/
6. Phenylmercury acetate is highly toxic to mammals and very small doses have produced renal lesions: teratogenic in the rat.
Acrolein [C] 107-02-8 1092 L H 2 29 EHC 127; HSG 67; IARC 63; ICSC 90
Allyl alcohol [C] 107-18-6 1098 L H 3 64 Highly irritant to skin and eyes; ICSC 95; Adjusted classification
(see note 3)
Azinphos-ethyl [ISO] 2642-71-9 2783 OP S I 2 12 DS 72; JMPR 1974
Azinphos-methyl [ISO] 86-50-0 2783 OP S I 2 16 DS 59; ICSC 826; JMPR 1992, 2009b
Blasticidin-S 2079-00-7 2588 S F 2 16
Butocarboxim [ISO] 34681-10-2 2992 C L I 3 158 JMPR 1986a; Adjusted classification (see note 3)
Butoxycarboxim [ISO] 34681-23-7 2992 C L I 3 D288 Adjusted classification (see note 3)
Cadusafos [ISO] 95465-99-9 3018 OP L N,I 2 37 JMPR 1992
Calcium arsenate [C] 7778-44-1 1573 AS S I 2 20 EHC 18, 224; IARC 84; ICSC 765; JMPR 1969
21
Carbofuran [ISO] 1563-66-2 2757 C S I 2 8 DS 56; ICSC 122; JMPR 1997b, 2003b, 2009a; See note 2.
Chlorfenvinphos [ISO] 470-90-6 3018 OP L I 2 31 ICSC 1305; JMPR 1995b
3-Chloro-1,2-propanediol 96-24-2 2689 L R 3 112 Adjusted classification (see notes 1 and 3)
[C]
Coumaphos [ISO] 56-72-4 2783 OP S AC,MT 2 7.1 ICSC 422; JMPR 1991
Coumatetralyl [ISO] 5836-29-3 3027 CO S R 2 16
Cyfluthrin [ISO] 68359-37-5 PY S I 2 c15 JMPR 2008; See note 9, p. 8
Beta-cyfluthrin [ISO] 68359-37-5 PY S I 2 c11 JMPR 2008; See note 9, p. 8
Zeta-cypermethrin [ISO] 52315-07-8 3352 PY L I 3 c86 See note 9, p. 8; HSG 22; ICSC 246; JMPR 2008; Adjusted
classification (see note 3)
Demeton-S-methyl [ISO] 919-86-8 3018 OP L I 2 40 DS 61, EHC 197; ICSC 705; JMPR 1990
Dichlorvos [ISO] 62-73-7 3018 OP L I 3 56 Volatile, DS 2; EHC 79; HSG 18; IARC 20, 53; ICSC 690; JMPR
1994; Adjusted classification (see note 3)
Dicrotophos [ISO] 141-66-2 3018 OP L I 2 22 ICSC 872
Dinoterb [ISO] 1420-07-1 2779 NP S H 2 25
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
DNOC [ISO] 534-52-1 2779 NP S I-S,H 2 25 JMPR 1965a; EHC 220; ICSC 462. See note 2.
Edifenphos [ISO] 17109-49-8 3018 OP L F 3 150 JMPR 1982. Adjusted classification (see note 3)
Ethiofencarb [ISO] 29973-13-5 2992 C L I 3 200 JMPR 1983. Adjusted classification (see note 3)
Famphur 52-85-7 2783 OP S I 2 48
Fenamiphos [ISO] 22224-92-6 2783 OP S N 2 15 DS 92; ICSC 483; JMPR 1998b, 2003b
Flucythrinate [ISO] 70124-77-5 3352 PY L I 3 c67 JMPR 1986b; see note 9, p.8; Adjusted classification (see note 3)
Fluoroacetamide [C] 640-19-7 2588 S R 2 13 ICSC 1434. See note 2
Formetanate [ISO] 22259-30-9 2757 C S AC 2 21
Furathiocarb 65907-30-4 2992 C L I-S 2 42
Heptenophos [ISO] 23560-59-0 3018 OP L I 3 96 Adjusted classification (see note 3)
Isoxathion [ISO] 18854-04-8 3018 OP L I 3 112 Adjusted classification (see note 3)
22
Lead arsenate [C] 7784-40-9 1617 AS S L 2 c10 EHC 18, 224; IARC 84; ICSC 911; JMPR 1969
Mecarbam [ISO] 2595-54-2 3018 OP Oil I 2 36 JMPR 1987a
Mercuric oxide [ISO] 21908-53-2 1641 HG S O 2 18 ICSC 981; CICAD 50. See note 2
Methamidophos [ISO] 10265-92-6 2783 OP S I 2 30 HSG 79; ICSC 176; JMPR 1991, 2003b; See note 2
Methidathion [ISO] 950-37-8 3018 OP L I 2 25 JMPR 1998b; ICSC 1659
Methiocarb [ISO] 2032-65-7 2757 C S I 2 20 JMPR 1999
Methomyl [ISO] 16752-77-5 2757 C S I 2 17 DS 55, EHC 178; HSG 97; ICSC 177, JMPR 1989, 2002
Monocrotophos [ISO] 6923-22-4 2783 OP S I 2 14 See note 2; HSG 80; ICSC 181; JMPR 1996b
Nicotine [ISO] 54-11-5 1654 L 1 D50 ICSC 519
Omethoate [ISO] 1113-02-6 3018 OP L I 2 50 JMPR 1997a
Oxamyl [ISO] 23135-22-0 2757 C S I 2 6 DS 54; JMPR 1986b, 2003b
Oxydemeton-methyl [ISO] 301-12-2 3018 OP L I 3 65 JMPR 1990, 2003b; Adjusted classification (see note 3)
Paris green [C] 12002-03-8 1585 AS S L 2 22 Copper-arsenic complex
Pentachlorophenol [ISO] 87-86-5 3155 S I,F,H 2 D80 See note 2; Irritant to skin; EHC 71; HSG 19; IARC 20, 53; ICSC 69
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
23
Zinc phosphide [C] 1314-84-7 1714 S R 2 45 DS 24, EHC 73; ICSC 602
EHC = Environmental Health Criteria Monograph; DS= Pesticide Data Sheet; HSG = Health and Safety Guide; IARC = IARC Monographs on the Evaluation of Carcinogenic
Risks to Humans; ICSC = International Chemical Safety Card; JMPR = Evaluation by the Joint FAO/WHO Meeting on Pesticide Residues.
Notes to Class Ib
1. 3-Chloro-1,2-propanediol in nonlethal dosage is a sterilant for male rats. This compound is also known as alpha chlorhydrin.
2. The international trade of carbofuran, DNOC, fluoroacetamide, mercury compounds, methamidophos, monocrotophos and pentachlorophenol is regulated by the
Rotterdam convention on Prior Informed Consent (see http://www.pic.int/), which entered into force on 24 February 2004. See Table 7, p. 51.
3. As a precautionary measure, the classification of certain liquid pesticides has been adjusted to avoid those pesticides being assigned to a less hazardous Class in the
process of aligning the WHO Classification with the GHS. Details of how the WHO Classification has been aligned with the GHS Acute Toxicity Hazard Categories are
described in the introductory notes for Part II.
Acephate [ISO] 30560-19-1 OP S I 4 945 JMPR 1991, 2003b, 2006b; ICSC 748
Acifluorfen [ISO] 50594-66-6 S H 4 1370 Strong irritant to eyes
Alachlor [ISO] 15972-60-8 2588 S H 4 930 See note 1; DS 86; IARC 19, 36, 63; ICSC 371
Alanycarb [ISO] 83130-01-2 C S I 4 330
Allethrin [ISO] 584-79-2 PY Oil I 4 c685 See note 9, page 8; EHC 87; HSG 24; ICSC 212; JMPR 1965a
Ametryn [ISO] 834-12-8 T S H 4 110
Amitraz [ISO] 33089-61-1 S AC 4 800 ICSC 98; JMPR 1999
Anilofos [ISO] 64249-01-0 OP S H 4 472
Azaconazole 60207-31-0 S F 4 308
Azamethiphos [ISO] 35575-96-3 OP S I 4 1010
24
Azocyclotin [ISO] 41083-11-8 2786 OT S AC 3 80 JMPR 1990, 1995b, 2006b
Bendiocarb [ISO] 22781-23-3 2757 C S I 3 55 DS 52
Benfuracarb [ISO] 82560-54-1 2992 C L I 3 205
Bensulide [ISO] 741-58-2 2902 L H 3 270 ICSC 383
Bensultap [ISO] 17606-31-4 S I 4 1100
Bentazone [ISO] 25057-89-0 S H 4 1100 HSG 48; ICSC 828; JMPR 1999, 2005
Bifenthrin 82657-04-3 3349 PY S I 3 c55 JMPR 1993
Bilanafos [ISO] 71048-99-2 S H 3 268
Bioallethrin [C] 584-79-2 PY L I 4 c700 See note 2; note 9, p. 8; ICSC 227
Bromoxynil [ISO] 1689-84-5 2588 S H 3 190
Bromuconazole 116255-48-2 S F 4 365 ICSC 1264
Bronopol 52-51-7 S B 3 254 ICSC 415
Butamifos [ISO] 36335-67-8 OP L H 4 630
Butralin [ISO] 33629-47-9 S H 4 1049
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
25
Chlorphonium chloride [ISO] 115-78-6 2588 S PGR 3 178 Irritant to skin and eyes
Chlorpyrifos [ISO] 2921-88-2 2783 OP S I 3 135 DS 18; ICSC 851; JMPR 2000
Clomazone [ISO] 81777-89-1 L H 4 1369
Copper hydroxide [C] 20427-59-2 CU S F 4 1000
Copper oxychloride [C] 1332-40-7 CU S F 4 1440
Copper sulfate [C] 7758-98-7 CU S F 3 300 ICSC 751
4-CPA [ISO] 122-88-3 PAA S PGR 4 850
Cuprous oxide [C] 1317-39-1 CU S F 4 470 ICSC 421, EHC 200
Cyanazine [ISO] 21725-46-2 T S H 3 288 ICSC 391
Cyanophos [ISO] 2636-26-2 OP L I 4 610
Cyhalothrin [ISO] 68085-85-8 3352 PY Oil Ix 3 c144 See note 9, p. 8; EHC 99; HSG 38; ICSC 858; JMPR 1985c;
JECFA 2000b
Cyhexatin [ISO] 13121-70-5 OT S AC 3 265 EHC 15; JMPR 1995b, 2006b
Cymoxanil [ISO] 57966-95-7 S F 4 1196
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
Cypermethrin [ISO] 52315-07-8 3352 PY L I 3 c250 See note 9, p. 8; DS 58; EHC 82; HSG 22; ICSC 246; JECFA 1996
Alpha-cypermethrin [ISO] 67375-30-8 3349 PY S I 3 c79 See note 9, p 8; EHC 142; JECFA 1996; JMPR 2008
Cyphenothrin [(1R)-isomers] 39515-40-7 3352 PY L I 4 318
[ISO]
Cyproconazole 94361-06-5 S F 4 1020
2,4-D [ISO] 94-75-7 3345 PAA S H 4 375 DS 37; EHC 29, 84; HSG 5; IARC 41, Suppl. 7; ICSC 33; JMPR
1998b
Dazomet [ISO] 533-74-4 S F-S 4 640 Irritant to skin and eyes; ICSC 786
2,4-DB 94-82-6 S H 4 700
DDT [ISO] 50-29-3 2761 OC S I 3 113 See notes 3 and 4; DS 21; EHC 9, 83; IARC 53; ICSC 34; JMPR
1985c, 2001
Deltamethrin [ISO] 52918-63-5 3349 PY S I 3 c135 See note 9, p. 8; DS 50; EHC 97; HSG 30; IARC 53; ICSC 247;
26
JMPR 2001
Diazinon [ISO] 333-41-5 3018 OP L I 4 300 DS 45, EHC 198; ICSC 137; JMPR 1994, 2002, 2008
Dicamba [ISO] 1918-00-9 S H 4 1707 ICSC 139
Dichlorobenzene [C] 106-46-7 S FM 4 500-5000 Mixture of isomers: ortho (3) 95-50-1, meta (3) 541-73-1, para (2B)
106-46-7; ICSC 37
Dichlorophen [ISO] 97-23-4 OC S F 4 1250
Dichlorprop [ISO] 7547-66-2 S H 4 800 ICSC 38
Diclofop [ISO] 40483-25-2 S H 4 565
Dicofol [ISO] 115-32-2 OC S AC 4 c690 DS 81; IARC 30; ICSC 752; JMPR 1993
Difenoconazole [ISO] 119446-68-3 S F 4 1453 JMPR 2009b
Difenzoquat [ISO] 43222-48-6 2588 S H 4 470
Dimepiperate [ISO] 61432-55-1 TC S H 4 946
Dimethachlor [ISO] 50563-36-5 S H 4 1600
Dimethipin [ISO] 55290-64-7 S H 4 1180 JMPR 2000, 2005
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
Dimethenamid [ISO] 87674-68-8 L H 4 371 LD50 of P isomer is 429 mg/kg bw; JMPR 2006b
Dimethylarsinic acid [C] 75-60-5 1572 AS S H 4 1350
Dimethoate [ISO] 60-51-5 2783 OP S I 3 c150 DS 42; EHC 90; HSG 20; ICSC 741; JMPR 1997b, 2004
Diniconazole [ISO] 83657-24-3 S F 4 639
Dinobuton [ISO] 973-21-7 2779 NP S AC,F 3 140
Dinocap [ISO] 39300-45-3 NP S AC,F 4 980 ICSC 881; JMPR 1999
Diphenamid [ISO] 957-51-7 S H 4 970 ICSC 763
Diquat [ISO] 2764-72-9 2781 BP S H 3 231 Irritant to skin and eyes and damages nails; DS 40; EHC 39; HSG
52; JMPR 1994; ICSC 1363
Dithianon [ISO] 3347-22-6 S F 4 640 JMPR 1993
Dodine [ISO] 2439-10-3 S F 4 1000 JMPR 2001
Endosulfan [ISO] 115-29-7 2761 OC S I 3 80 DS 15; EHC 40; HSG 17; ICSC 742; JMPR 1999
27
Endothal-sodium [(ISO)] 125-67-9 2588 S H 3 51
EPTC [ISO] 759-94-4 TC L H 4 1652 ICSC 469
Esfenvalerate [ISO] 66230-04-4 3349 PY S I 3 87 JMPR 2003b; ICSC 1516
Ethion [ISO] 563-12-2 3018 OP L I 3 208 ICSC 888; JMPR 1991
Fenazaquin [ISO] 120928-09-8 2588 S AC 3 134
Fenitrothion [ISO] 122-14-5 OP L I 4 503 DS 30; EHC 133; HSG 65; ICSC 622; JMPR 2001
Fenobucarb 3766-81-2 C S I 4 620
Fenothiocarb [ISO] 62850-32-2 C S L 4 1150
Fenpropidin [ISO] 67306-00-7 L F 4 1440
Fenpropathrin [ISO] 64257-84-7 3349 PY S I 3 c66 See note 9, p. 8; JMPR 1994
Fenpyroximate [ISO] 134098-61-6 S AC 3 245 Highly toxic by inhalation (LC50 = 0.21-0.36 mg/l); JMPR 2007
Fenthion [ISO] 55-38-9 3018 OP L I,L 3 D586 DS 23; ICSC 655; JMPR 1998b
Fentin acetate[(ISO)] 900-95-8 2786 OT S F 3 125 DS 22; EHC 15; JMPR 1992; CICAD 13
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
Fentin hydroxide[(ISO)] 76-87-9 2786 OT S F 3 108 DS 22; EHC 15; ICSC 1283; JMPR 1992; CICAD 13
Fenvalerate [ISO] 51630-58-1 3352 PY L I 4 c450 See note 9, p. 8; DS 90; EHC 95, HSG 34; IARC 53; ICSC 273;
JMPR 1986c
Ferimzone [ISO] 89269-64-7 S F 4 725
Fipronil 120068-37-3 2588 S I 3 92 JMPR 1998b, 2001; ICSC 1503
Fluchloralin [ISO] 33245-39-5 S H 4 1550
Flufenacet [ISO] 142459-58-3 S H 4 600 May cause skin sensitization
Fluoroglycofen 77501-60-1 S H 4 1550
Flurprimidol [ISO] 56425-91-3 S PGR 4 709
Flusilazole 85509-19-9 S F 4 672 JMPR 1996b, 2009b
Flutriafol [ISO] 76674-21-0 S F,FST 4 1140
Fluxofenim [ISO] 88485-37-4 oil H 4 670
28
Fomesafen [ISO] 72178-02-0 OC S H 4 1250
Fuberidazole [ISO] 3878-19-1 S F 4 336
Furalaxyl [ISO] 57646-30-7 S F 4 940
Gamma-HCH [ISO], Lindane 58-89-9 2761 OC S I 3 88 ICSC 53; JMPR 2003b; See note 3
Glufosinate [ISO] 53369-07-6 S H 4 1625 JMPR 2000
Guazatine 108173-90-6 S FST 3 230 LD50 value refers to triacetate; JMPR 1998b
Haloxyfop 69806-34-4 S H 4 300 JMPR 1996b, 2008 (includes Haloxyfop-R and esters)
HCH [ISO] 608-73-1 2761 OC S I 3 100 See notes 3, 4 and 5; EHC 123; IARC 5, 20, 42; ICSC 487; JMPR
1974
Hexazinone [ISO] 51235-04-2 S H 4 1690
Hydramethylnon 67485-29-4 S I 4 1200
Imazalil [ISO] 35554-44-0 2588 S F 3 227 ICSC 1303; JMPR 2001, 2002, 2006b
Imidacloprid [ISO] 138261-41-3 S I 4 450 JMPR 2002; ICSC 1501
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
29
MCPA-thioethyl [ISO] 25319-90-8 PAA S H 4 790
MCPB [ISO] 94-81-5 S H 4 680
Mecoprop [ISO] 7085-19-0 S H 4 930 ICSC 55
Mecoprop-P [ISO] 16484-77-8 S H 4 1050
Mefluidide [ISO] 53780-34-0 S H 4 1920
Mepiquat [ISO] 15302-91-7 S PGR 4 1490
Mercurous chloride [C] 10112-91-1 2025 HG S F 3 210 See note 3; ICSC 984; CICAD 50
Metalaxyl [ISO] 57837-19-1 S F 4 670 JMPR 1983, 2003b
Metaldehyde [ISO] 108-62-3 S M 3 227 DS 93
Metamitron [ISO] 41394-05-2 S H 4 1183 ICSC 1361
Metam-sodium [(ISO)] 137-42-8 2771 S F-S 3 285
Metconazole [ISO] 125116-23-6 S F 4 660
Methacrifos [ISO] 62610-77-9 OP L I 4 678 JMPR 1991
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
30
Nuarimol [ISO] 63284-71-9 S F 4 1250
Octhilinone [ISO] 26530-20-1 S F 4 1470
Oxadixyl 77732-09-3 S F 4 1860
Paclobutrazol [ISO] 76738-62-0 S PGR 4 1300 JMPR 1989
Paraquat [ISO] 1910-42-5 2781 BP S H 3 150 See note 7; DS 4; EHC 39; HSG 51; ICSC 5; JMPR 1987a, 2004
Pebulate [ISO] 1114-71-2 TC L H 4 1120
Pendimethalin [ISO] 40487-42-1 S H 4 1050
Permethrin [ISO] 52645-53-1 3352 PY L I 4 c500 See note 9, p. 8; DS 51; EHC 94; HSG 33; IARC 53; ICSC 312;
JMPR 2000
Phenthoate [ISO] 2597-03-7 3018 OP L I 4 c400 DS 48; JMPR 1985c
Phosalone [ISO] 2310-17-0 2783 OP S I 3 120 ICSC 797; JMPR 1998b, 2002
Phosmet [ISO] 732-11-6 2783 OP S I,AC 3 113 ICSC 543; JMPR 1999, 2004
Phoxim [ISO] 14816-18-3 OP L I 4 D1975 DS 31; JECFA 2000a
Piperophos [ISO] 24151-93-7 3018 OP oil H 4 324
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
31
Pyraclofos [ISO] 77458-01-6 3018 OP L I 3 237
Pyrazophos [ISO] 13457-18-6 2784 S F 4 435 JMPR 1993
Pyrazoxyfen [ISO] 71561-11-0 S H 4 1644
Pyrethrins [C] 8003-34-7 L I 4 500-1000 See note 8; DS 11; JMPR 2000, 2004; ICSC 1475
Pyridaben [ISO] 96489-71-3 S AC 4 820
Pyridaphenthion 119-12-0 OP S I 4 769
Pyroquilon [ISO] 57369-32-1 S F 4 320
Quinalphos [ISO] 13593-03-8 2783 OP S I 3 62
Quinoclamine [ISO] 2797-51-5 S H 4 1360
Quizalofop 76578-12-6 S H 4 1670
Quizalofop-p-tefuryl [ISO] 119738-06-6 L H 4 1012
Rotenone [C] 83-79-4 2588 S I 3 132-1500 See note 9; HSG 73; ICSC 944
Simetryn [ISO] 1014-70-6 T S H 4 1830
Sodium chlorate [ISO] 7775-09-9 1495 S H 4 1200 ICSC 1117
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
Spiroxamine [ISO] 118134-30-8 L F 4 500 Dermal LD50 1068 mg/kg; may cause skin sensitisation
Sulfluramid [ISO] 4151-50-2 S I 4 543
2,3,6-TBA [ISO] 50-31-7 S H 4 1500
TCA [ISO] (acid) 76-03-9 1839 S 4 400 See note 5 to Table 4, p. 38; ICSC 586
Tebuconazole [ISO] 107534-96-3 S F 4 1700 JMPR 1995b
Tebufenpyrad [ISO] 119168-77-3 S MT 4 595
Tebuthiuron [ISO] 34014-18-1 S H 4 644
Terbumeton [ISO] 33693-04-8 T S H 4 483
Tetraconazole [ISO] 112281-77-3 Oil F 4 1031
Thiacloprid 111988-49-9 S I 4 396 JMPR 2008
Thiobencarb [ISO] 28249-77-6 TC L H 4 1300
32
Thiocyclam [ISO] 31895-22-4 S I 4 310
Thiodicarb [ISO] 59669-26-0 2757 C S I 3 66 JMPR 2001
Thiram [ISO] 137-26-8 S F 4 560 DS 71; EHC 78; IARC 12, 53; ICSC 757; JMPR 1993; See note 3
Tralkoxydim [ISO] 87820-88-0 S H 4 934
Tralomethrin 66841-25-6 3349 PY S I 3 c85
Triadimefon [ISO] 43121-43-3 S F 4 602 JMPR 1986b, 2005
Triadimenol [ISO] 55219-65-3 S FST 4 900 JMPR 1990, 2005
Triazamate [ISO] 112143-82-5 2588 S AP 3 50-100
Trichlorfon [ISO] 52-68-6 OP S I 3 250 DS 27; EHC 132; HSG 66; IARC 30, Suppl 7; ICSC 585; JMPR
1979; JECFA 2000b, 2003
Triclopyr [ISO] 55335-06-3 S H 4 710
Tricyclazole [ISO] 41814-78-2 S F 4 305
Tridemorph [ISO] 81412-43-3 Oil F 4 650
Triflumizole 99387-89-0 S F 4 695 ICSC 1252
Common name CAS no UN Chem Phys Main GHS LD50 Remarks
no type state use mg/kg
EHC = Environmental Health Criteria Monograph; DS= Pesticide Data Sheet; HSG = Health and Safety Guide; IARC = IARC Monographs on the Evaluation of Carcinogenic
Risks to Humans; ICSC = International Chemical Safety Card; JECFA = Evaluation by the Joint FAO/WHO Expert Committee on Food Additives; JMPR = Evaluation by
the Joint FAO/WHO Meeting on Pesticide Residues.
Notes to Class II
1. Alachlor was previously classified as a Class Ia pesticide due to its carcinogenicity in rats. However mechanistic studies have indicated that tumors are induced by a
mechanism not relevant to humans.
2. Bioallethrin, esbiothrin, esbiol, and esdepalléthrine are members of a series; their toxicity varies considerably within this series, according to concentrations of
33
isomers.
3. The international trade of chlordane, DDT, Gamma-HCH (lindane), HCH, mercury compounds and thiram is regulated by the Rotterdam convention on Prior Informed
Consent (see http://www.pic.int/), which entered into force on 24 February 2004. See Table 7, p. 51.
4. The production and use of chlordane, DDT, Gamma-HCH (lindane) and HCH (specifically alpha-HCH and beta-HCH) are strictly limited by the Stockholm convention
on persistent organic pollutants, which entered into force on 17 May, 2004 and has subsequently been amended. See http://www.pops.int/.
5. HCH: The LD50 varies according to the mixture of isomers. The value shown has been chosen, and the technical product placed in Class II, as a result of the cumulative
properties of the beta isomer.
6. The melting point of methyl isothiocyanate (S) is 35°C.
7. Paraquat has serious delayed effects if absorbed. It is of relatively low hazard in normal use but may be fatal if the concentrated product is taken by mouth or spread on
the skin.
8. Mixture of compounds present in Pyrethrum cineraefolium and other flowers.
9. Compounds from roots of Derris and Lonchocarpus spp.
Common name CAS no UN Chem Phys Main use GHS LD50 Remarks
no type state mg/kg
34
Biphenyl 92-52-4 S F 5 3280 ICSC 106
Bispyribac 125401-75-4 S H 5 2635
Borax [ISO] 1303-96-4 S F 5 4500 ICSC 567
Bupirimate [ISO] 41483-43-6 S F 5 c4000
Buprofezin [ISO] 69327-76-0 S I 5 2200 JMPR 1992
Butachlor 23184-66-9 L H 5 3300
Butylate [ISO] 2008-41-5 TC L F 5 >4000
Carboxin [ISO] 5234-68-4 S FST 5 3820
Chinomethionat [ISO] 2439-01-2 S AC,F 5 2500 JMPR 1988
Chloridazon [ISO] 1698-60-8 S H 5 2420
Chlorimuron 99283-00-8 S H 5 4102
Chlorpyrifos methyl [ISO] 5598-13-0 OP S I 5 >3000 DS 33; JMPR 1993
Chlorthal-dimethyl [ISO] 1861-32-1 S H 5 >3000
Chlozolinate 84332-86-5 S F 5 >4000
Common name CAS no UN Chem Phys Main use GHS LD50 Remarks
no type state mg/kg
35
Diflubenzuron 35367-38-5 S L 5 >4640 DS 77, EHC 184; HSG 99; JMPR 2002
Diflufenican [ISO] 83164-33-4 S H 4 >2000
Dimefuron [ISO] 34205-21-5 S H 4 >2000
Dimethametryn [ISO] 22936-75-0 T L H 5 3000
Dimethirimol 5221-53-4 S F 5 2350
Dimethomorph [ISO] 110488-70-5 S F 5 3500 JMPR 2009b
Dinitramine [ISO] 29091-05-2 S H 5 3000
Diuron [ISO] 330-54-1 S H 5 3400
Dodemorph [ISO] 1593-77-7 L H 5 4500
Empenthrin [(1R) isomers] [ISO] 54406-48-3 PY Oil I 5 >2280
Esprocarb [ISO] 85785-20-2 TC L H 4 >2000 Skin and eye irritant
Ethephon 16672-87-0 S PGR 5 >4000 JMPR 2004; 2003b
Etridiazole [ISO] 2593-15-9 L F 4 2000
Common name CAS no UN Chem Phys Main use GHS LD50 Remarks
no type state mg/kg
36
Halofenozide 112226-61-6 S I 5 2850
Hexaconazole 79983-71-4 S F 5 2180 JMPR 1991
Hymexazol 10004-44-1 S FST 5 3900
Iprodione [ISO] 36734-19-7 S F 5 3500 JMPR 1996b
Linuron [ISO] 330-55-2 S H 5 4000 ICSC 1300
Malathion [ISO] 121-75-5 3082 OP L I 5 c2100 See note 1; DS 29; IARC 30; ICSC 172; JMPR 1998b,
2004
Metazachlor 67129-08-2 S H 5 2150
Methabenzthiazuron [ISO] 18691-97-9 S H 5 >2500
Methyldymron 42609-73-4 S H 5 3948
Metobromuron [ISO] 3060-89-7 S H 5 2500
Metolachlor [ISO] 51218-45-2 L H 5 2780 ICSC 1360
Metoxuron 19937-59-8 S H 5 >3200
Monolinuron 1746-81-2 S H 5 2250 ICSC 1273
Common name CAS no UN Chem Phys Main use GHS LD50 Remarks
no type state mg/kg
37
Pyridate [ISO] 55512-33-9 S H 5 c2000
Pyrifenox [ISO] 88283-41-4 L F 4 2900
Pyrimethanil [ISO] 53112-28-0 S F 5 4150 JMPR 2009b
Pyrithiobac sodium [ISO] 123343-16-8 S H 5 3200
Quinclorac 84087-01-4 S H 5 2680
Resmethrin [ISO] 10453-86-8 PY S I 4 2000 See note 3; EHC 92, DS 83, HSG 25; ICSC 324
Sethoxydim [ISO] 74051-80-2 L H 5 3200
Spinosad [ISO] 168316-95-8 S I 5 3738 For Spinosyn A and D, CAS numbers are 131929-60-7 and
131929-63-0;
JMPR 2002; ICSC 1502
Spirotetramat [ISO] 203313-25-1 S I 4 >2000 JMPR 2009a
Sulphur 7704-34-9 1350 S F,I 5 >3000 Skin and mucous membrane irritant. See note 4; ICSC 1166
TCA (sodium salt) [ISO] 650-51-1 S H 5 3200 ICSC 1139; Irritant to skin and eyes: see note 5
Temephos [ISO] 3383-96-8 OP L I 5 4000 DS 8; ICSC 199; JMPR 2008
Common name CAS no UN Chem Phys Main use GHS LD50 Remarks
no type state mg/kg
EHC = Environmental Health Criteria Monograph; DS = Pesticide Data Sheet; HSG = Health and Safety Guide; IARC = IARC Monographs on the Evaluation of
Carcinogenic Risks to Humans; ICSC = International Chemical Safety Card; JECFA = Evaluation by the Joint FAO/WHO Expert Committee on Food Additives; JMPR =
38
Evaluation by the Joint FAO/WHO Meeting on Pesticide Residues.
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
39
Benoxacor [ISO] 98730-04-2 S H 5 >5000 This molecule is not an active substance as such but is
a “safener”
Bensulfuron-methyl 83055-99-6 S H 5 >5000
Bifenazate [ISO] 149877-41-8 S AC 5 >5000 JMPR 2008
Bifenox [ISO] 42576-02-3 S H 5 >6400
Bioresmethrin [ISO] 28434-01-7 PY L I 5 >7000 DS 34; EHC 92; HSG 25; ICSC 229; JMPR 1992
Bitertanol 55179-31-2 S F 5 >5000 JMPR 1999
Boscalid [ISO] 188425-85-6 S F 5 >5000 JMPR 2008
Bromacil [ISO] 314-40-9 S H 5 5200 ICSC 1448
Bromobutide 74712-19-9 S H 5 >5000
Bromopropylate [ISO] 18181-80-1 S AC 5 >5000 JMPR 1994
Captan [ISO] 133-06-2 S F 5 9000 Irritant to skin; DS 9; HSG 50; IARC 30, Suppl 7;
ICSC 120; JMPR 1996b, 2005
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
Carbendazim [ISO] 10605-21-7 S F 5 >10000 DS 89; EHC 149; HSG 82; ICSC 1277; JMPR 1996b,
2006b
Carbetamide [ISO] 16118-49-3 C S H 5 >10000
Carpropamid [ISO] 104030-54-8 L F 5 >5000
Chloransulam methyl 14750-35-4 S H 5 >5000
Chlorantraniliprole [ISO] 500008-45-7 S I 5 >5000 JMPR 2009a
Chlorfluazuron 71422-67-8 S IGR 5 8500
Chlorothalonil [ISO] 1897-45-6 S F 5 >10000 EHC 183; HSG 98; IARC 30; ICSC 134; JMPR 1993
Chlorotoluron [ISO] 15545-48-9 S H 5 >10000 ICSC 1327
Chlorpropham [ISO] 101-21-3 C S PGR 5 >5000 IARC 12; JMPR 2001; ICSC 1500
Chlorsulfuron 64902-72-3 S H 5 5545
Cinosulfuron [ISO] 94593-91-6 S H 5 >5000
40
Clomeprop 84496-56-0 S H 5 >5000
Cloxyfonac 32791-87-0 PAA S PGR 5 >5000
Cryolite [C] 15096-52-3 S I 5 >10000
Cycloprothrin 63935-38-6 PY L I 5 >5000
Cyclosulfamuron [ISO(*)] 136849-15-5 S H 5 >5000
Cyhalofop [ISO] 122008-85-9 S H 5 >5000
Daimuron 42609-52-9 S H 5 >5000
Dalapon 75-99-0 S H 5 9330
Daminozide [ISO] 1596-84-5 S H 5 8400 JMPR 1993
Desmedipham [ISO] 13684-56-5 S H 5 >9600
Dichlofluanid [ISO] 1085-98-9 S F 5 >5000 JMPR 1985a
Diclomezine 62865-36-5 S F 5 >10000
Diclosulam [ISO] 145701-21-9 S H 5 >5000
Diethofencarb 87130-20-9 S F 5 >5000
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
41
Famoxadone [ISO(*)] 131807-57-3 S F 5 >5000 JMPR 2004
Fenchlorazole [ISO] 103112-35-2 S H 5 >5000
Fenclorim 3740-92-9 S H 5 >5000
Fenfuram [ISO] 24691-80-3 S FST 5 >10000
Fenhexamid [ISO] 126833-17-8 S F 5 >5000 JMPR 2006b
Fenoxycarb 79127-80-3 C S I 5 >10000
Fenpiclonil 74738-17-3 S FST 5 >5000
Ferbam [ISO] 14484-64-1 S F 5 >10000 DS 94; EHC 78; IARC 12, 42; ICSC 792; JMPR
1997b
Florasulam 145701-23-1 S H 5 >5000
Flucarbazone-sodium 181274-17-9 S H 5 > 5000
Flucycloxuron [ISO] 94050-52-9 S AC 5 >5000
Fludioxonil [ISO] 131341-86-1 S F 5 >5000 JMPR 2006a
Flumetralin 62924-70-3 S PGR 5 >5000
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
42
Gibberellic acid 77-06-5 S PGR 5 >10000
Hexaflumuron [ISO] 86479-06-3 S I 5 >5000 ICSC 1266
Hexythiazox 78587-05-0 S AC 5 >5000 JMPR 1992, 2009a
Hydroprene [ISO] 41205-09-8 L IGR 5 >10000
2-Hydroxyethyl octyl sulphide [C] 3547-33-9 L RP 5 8530
(insect)
Imazamethabenzmethyl [(ISO)] 81405-85-8 S H 5 >5000
Imazapyr 81334-34-1 S H 5 >5000 Irritant to eyes
Imazaquin 81335-37-7 S H 5 >5000
Imazethapyr 81335-77-5 S H 5 >5000
Imibenconazole [ISO] 86598-92-7 S F 5 >5000
Inabenfide 82211-24-3 S PGR 5 >10000
Iprovalicarb 140923-17-7 S F 5 >5000
Isoxaben 82558-50-7 S H 5 >10000
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
43
Methoxychlor [ISO] 72-43-5 OC S I 5 6000 DS 28; IARC 5, 20; ICSC 1306; JMPR 1978
Methozyfenozide 161050-58-4 S I 5 >5000 Dermal LD50 > 5000; JMPR 2004
Metiram 9006-42-2 S F 5 >10000 JMPR 1994
Metosulam 139528-85-1 S H 5 >5000
Metsulfuron methyl 74223-64-6 S H 5 >5000
2-(1-Naphthyl) acetamide 86-86-2 S PGR 5 6400
Napropamide 15299-99-7 S H 5 5000
Naptalam 132-66-1 S PGR 5 8200
Neburon [ISO] 555-37-3 S H 5 >10000
Niclosamide [ISO] 50-65-7 S M 5 5000 DS 63
Nicosulfuron [ISO] 111991-09-4 S H 5 >5000 Irritant to eyes
Nitrothal-isopropyl [ISO] 10552-74-6 S F 5 6400
Norflurazon [ISO] 27314-13-2 S H 5 >8000
Novaluron [ISO] 116714-46-6 S I 5 >5000 JMPR 2006b
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
44
Phosphorus acid [C] 13598-36-2 L F 5 >5000
Phthalide 27355-22-2 S F 5 >10000
Picloram [ISO] 1918-02-1 S H 5 8200 ICSC 1246
Piperonyl butoxide 51-03-6 Oil SY 5 >7500 IARC 30; JMPR 1996b; ICSC 1347
Pretilachlor [ISO] 51218-49-6 L H 5 6100
Primisulfuron [ISO] 113036-87-6 S H 5 >5050
Procymidone [ISO] 32809-16-8 S F 5 6800 JMPR 1990, 2009b
Prodiamine [ISO] 29091-21-2 S H 5 >5000
Propamocarb 24579-73-5 S F 5 8600 JMPR 1987a
Propaquizafop 111479-05-1 S H 5 >5000 ICSC 1271
Propazine [ISO] 139-40-2 T S H 5 >5000 ICSC 697
Propham [ISO] 122-42-9 S H 5 5000 IARC 12; JMPR 1993
Propineb [ISO] 12071-83-9 S H 5 8500 DS 94; EHC 78; JMPR 1994
Propyzamide [ISO] 23950-58-5 S H 5 5620
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
45
Spinetoram [ISO] 187166-40-1 S I 5 >5000 JMPR 2009a
Sulfometuron 74223-56-6 S H 5 >5000
Tebufenozide 112410-23-8 S I 5 >5000 Dermal LD50 > 5000; JMPR 1997b, 2004
Tebutam 35256-85-0 Oil H 5 6210
Tecnazene [ISO] 117-18-0 S F 5 >10000 EHC 42; HSG 12; JMPR 1995b
Teflubenzuron 83121-18-0 S I 5 >5000 JMPR 1995b
Terbacil [ISO] 5902-51-2 S H 5 >5000
Tetradifon [ISO] 116-29-0 S AC 5 >10000 EHC 67; HSG 11; ICSC 747
Tetramethrin [ISO] 7696-12-0 PY S O 5 >5000 EHC 98; HSG 31; ICSC 334
Thifensulfuron-methyl 79277-27-3 S H 5 >5000
Thifluzamide 130000-40-7 S F 5 >5000 Dermal LD50 > 5000
Thiophanate-methyl [ISO] 23564-05-8 S F 5 >6000 JMPR 1996b, 1999, 2008
Tiocarbazil 36756-79-3 TC L H 5 10000
Tolclofos-methyl [ISO] 57018-04-9 S F-S 5 c5000 JMPR 1995b
Common name CAS no UN no Chem Phys Main use GHS LD50 Remarks
type state mg/kg
46
Zineb [ISO] 12122-67-7 S F 5 >5000 DS 94; EHC 78; IARC 12; ICSC 350; JMPR 1994
Zoxamide [ISO] 156052-68-5 S F 5 >5000 JMPR 2009b
EHC = Environmental Health Criteria Monograph; DS= Pesticide Data Sheet; HSG = Health and Safety Guide; IARC = IARC Monographs on the Evaluation of Carcinogenic
Risks to Humans; ICSC = International Chemical Safety Card; JMPR = Evaluation by the Joint FAO/WHO Meeting on Pesticide Residues.
Notes to Table 5
1. The international trade of benomyl is regulated by the Rotterdam convention on Prior Informed Consent (see http://www.pic.int/), which entered into force on 24 February
2004. See Table 7, p. 51.
Ingredients discontinued have been identified from the previous edition of this classification,
from the Pesticide Manual (Pesticide Manual, 1991, 1994; 1997, 2003), and in some cases
from the manufacturer. It is difficult, in some cases, to be sure whether or not all commercial
activity in a substance has ceased; some of these materials are known to be still in use for
non-agricultural purposes. IPCS will be grateful for details of any materials in this Section,
which are still in commercial use. The common name and CAS number are indicated.
47
TABLE 6. ACTIVE INGREDIENTS BELIEVED TO BE OBSOLETE OR DISCONTINUED
FOR USE AS PESTICIDES, continued
48
TABLE 6. ACTIVE INGREDIENTS BELIEVED TO BE OBSOLETE OR DISCONTINUED
FOR USE AS PESTICIDES, continued
49
TABLE 6. ACTIVE INGREDIENTS BELIEVED TO BE OBSOLETE OR DISCONTINUED
FOR USE AS PESTICIDES, continued
dieldrin, dinoseb and dinoseb salts, heptachlor, mercury compounds, and 2,4,5-T is regulated by the Rotterdam
convention on Prior Informed Consent (see http://www.pic.int/), which entered into force on 24 February
2004, with subsequent amendments. See Table 7, p. 51.
The use and production of aldrin, camphechlor (toxaphene), chlordecone, dieldrin, endrin, heptachlor and
2
mirex is prohibited or severely restricted by the Stockholm convention on persistent organic pollutants, which
entered into force on 17 May, 2004, with subsequent amendments. See http://www.pops.int/
50
Table 7. Pesticides subject to the Rotterdam Convention1
51
Ia Parathion (all formulations – aerosols, dustable powder (DP), 56-38-2
emulsifiable concentrate (EC), granules (GR) and wettable
powders (WP) of this substance are included, except capsule
suspensions (CS)
Ia Phosphamidon (soluble liquid formulations of the substance that 13171-21-6 [mixture,
exceed 1000 g active ingredient/L) (E) & (Z) isomers]
23783-98-4 [(Z)-isomer]
297-99-4 [(E)-isomer]
Tributyltin compounds, including: tributyltin oxide; tributyltin
benzoate; tributyltin chloride; tributyltin fluoride; tributyltin
linoleate; tributyltin methacrylate; tributyltin naphthenate
1
According to the Rotterdam Convention, export of a chemical can only take place with the prior informed
consent of the importing Party. The Prior Informed Consent (PIC) procedure is a means for formally obtaining
and disseminating the decisions of importing countries as to whether they wish to receive future shipments
of a certain chemical and for ensuring compliance to these decisions by exporting countries. The aim is to
promote a shared responsibility between exporting and importing countries in protecting human health and
the environment from the harmful effects of such chemicals (further information can be found at: http://www.
pic.int/). The Rotterdam Convention (which entered into force on 24 February 2004) built on the voluntary
PIC procedure which was initiated by UNEP and FAO in 1989.
The use and production of aldrin, chlordane, DDT, dieldrin, heptachlor, hexachlorobenzene and lindane is
2
prohibited or severely restricted by the Stockholm convention on persistent organic pollutants, which entered
into force on 17 May, 2004. See http://www.pops.int/
52
TABLE 8. GASEOUS OR VOLATILE FUMIGANTS NOT CLASSIFIED UNDER THE
WHO RECOMMENDED CLASSIFICATION OF PESTICIDES BY HAZARD
The Classification does not set out any criteria for air concentrations on which classification
could be based. Most of these compounds are of high hazard and recommended exposure limits
for occupational exposure have been adopted by national authorities in many countries.
Aluminium phosphide 20859-73-8 DS 46; EHC 73; HSG 28; JMPR 1967
Chloropicrin 76-06-2 JMPR 1965b
1,2-Dibromoethane 106-93-4 EHC 177; IARC 15
1,3-Dichloropropene 542-75-6 EHC 146; HSG 76; IARC 41
Ethylene dichloride 107-06-2 EHC 62, 176; HSG 55; IARC 20
Ethylene oxide 75-21-8 EHC 55; HSG 16; JMPR 1969; IARC 11, 36, 42
Formaldehyde 50-00-0 EHC 89; HSG 57
Hydrogen cyanide 74-90-8 JMPR 1965b
Magnesium phosphide 12057-74-8 EHC 73; HSG 28
Methyl bromide 74-83-9 DS 5; EHC 166; HSG 86; IARC 41, 45; JMPR 1967
Phosphine 7803-51-2 DS 46; EHC 73; HSG 28; JMPR 1967
Sulfuryl fluoride 2699-79-8 JMPR 2006b
EHC = Environmental Health Criteria Monograph; DS = Pesticide Data Sheet; HSG = Health and Safety
Guide; IARC = IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; ICSC = International
Chemical Safety Card; JMPR = Evaluation by the Joint FAO/WHO Meeting on Pesticide Residues.
53
ANNEX
The following tables A and B can be used to find the hazard class of a formulation. These
should be used only if toxicity data is not available on the formulation itself; see the note at
the top of page 7.
Step 1: What is the approved name of the active ingredient in the pesticide? Use the
index to find the entry in tables 1-5 of the Guidelines.
Step 2: From the entry in the Guidelines, what is the route of application used for the
classification?
If the route is O (oral), use table A of this Annex. The same table is used for
solids and liquids.
If the route is D (dermal), use table B of this Annex. The same table is used
for solids and liquids.
Step 3: From the entry in the Guidelines, what is the LD50 of the active ingredient?
Using the table A or B, selected in Step 2, find the column along the top line
which most nearly includes the LD50 figure.
Using the same table A or B, find the figure in the left hand column which
most nearly includes this percentage figure.
Step 5: Find the square where the column selected in Step 3 crosses the line
selected in Step 4. The number in this square is the approximate LD50 of the
formulation.
Step 6: The hazard classes are shown by blocks of squares. The hazard class of the
formulation is that of the block in which lies the square selected in Step 5.
These tables can also be used to find the hazard class of mixtures. First see page 7, para. 4
of the Guidelines and select the method to be used to arrive at the LD50 of the mixture. For
method (b), use the above method from Step 1, using the name of the more or most toxic
ingredient. For method (c), pass to Step 4 using the total percentages of all active ingredients
in the mixture.
54
Table A. LD50 values and classification of formulations when the route is ORAL
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
57
Pesticide active ingredients, which occur in Tables 1-8, in CAS no order, continued
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
58
Pesticide active ingredients, which occur in Tables 1-8, in CAS no order, continued
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
59
Pesticide active ingredients, which occur in Tables 1-8, in CAS no order, continued
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
60
Pesticide active ingredients, which occur in Tables 1-8, in CAS no order, continued
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
61
Pesticide active ingredients, which occur in Tables 1-8, in CAS no order, continued
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
62
Pesticide active ingredients, which occur in Tables 1-8, in CAS no order, continued
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
63
Pesticide active ingredients, which occur in Tables 1-8, in CAS no order, continued
For each active ingredient, the classification (Ia, Ib, II, III, or U (unlikely to pose an acute
hazard in normal use, O (obsolete), FM (fumigant), and page number(s) are given.
64
INDEX. Classification of active pesticide ingredients
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
65
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
66
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
67
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
68
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
69
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
70
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
71
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
72
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
73
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
74
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
75
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
76
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
77
INDEX. Classification of active pesticide ingredients, continued
Ia = Extremely hazardous; Ib = Highly hazardous; II = Moderately hazardous;
III = slightly hazardous; U = Unlikely to present acute hazard in normal use;
FM = Fumigant, not classified; O = Obsolete as pesticide, not classified.
78