Professional Documents
Culture Documents
Mathematical Modeling To Inform Vaccination Strategies and Testing Approaches For
Mathematical Modeling To Inform Vaccination Strategies and Testing Approaches For
Rebecca Kahn*1,2, Inga Holmdahl*1, Sujan Reddy2, John Jernigan2, Michael J. Mina1,3,4,, Rachel
B. Slayton2**
* contributed equally
**correspondence to: [email protected]
1
Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H.
Chan School of Public Health, Boston, Massachusetts
2
COVID-19 Response, US Centers for Disease Control and Prevention, Atlanta, Georgia
3
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public
Health, Boston, Massachusetts
4
Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston,
Massachusetts
The findings and conclusions in this report are those of the authors and do not necessarily represent the
official position of the Centers for Disease Control and Prevention (CDC).
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Summary
The extent of efficacy of SARS-CoV-2 vaccines against infection, infectiousness, or disease,
impacts strategies for vaccination and testing in nursing homes. If vaccines confer some
protection against infection or infectiousness, encouraging vaccination in staff may reduce
symptomatic cases in residents.
Abstract
Background
Nursing home residents and staff were included in the first phase of COVID-19 vaccination in
the United States. Because the primary trial endpoint was vaccine efficacy (VE) against
symptomatic disease, there are limited data on the extent to which vaccines protect against
SARS-CoV-2 infection and the ability to infect others (infectiousness). Assumptions about VE
against infection and infectiousness have implications for possible changes to infection
prevention guidance for vaccinated populations, including testing strategies.
Methods
We use a stochastic agent-based SEIR model of a nursing home to simulate SARS-CoV-2
transmission. We model three scenarios, varying VE against infection, infectiousness, and
symptoms, to understand the expected impact of vaccination in nursing homes, increasing staff
vaccination coverage, and different screening testing strategies under each scenario.
Results
Increasing vaccination coverage in staff decreases total symptomatic cases in each scenario.
When there is low VE against infection and infectiousness, increasing staff coverage reduces
symptomatic cases among residents. If vaccination only protects against symptoms, but
asymptomatic cases remain infectious, increased staff coverage increases symptomatic cases
among residents through exposure to asymptomatic but infected staff. High frequency testing is
needed to reduce total symptomatic cases if the vaccine has low efficacy against infection and
infectiousness, or only protects against symptoms.
Conclusions
Encouraging staff vaccination is not only important for protecting staff, but might also reduce
symptomatic cases in residents if a vaccine confers at least some protection against infection or
infectiousness.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Background
Nursing homes have been devastated by the ongoing COVID-19 pandemic in the United States
[1]. Nursing home residents are disproportionately affected by severe disease and mortality due
to their older age and high prevalence of comorbidities. In addition, congregate living and
necessarily close contacts (e.g. assistance with activities of daily living) between staff and
residents have made controlling outbreaks in these settings more challenging than in the
general community. Because of this, residents and staff of long-term care facilities have been
included in the Advisory Committee on Immunization Practices’ first phase (1a) for vaccination,
alongside healthcare personnel [2]. Vaccine rollout began in nursing homes across the country
in late December 2020 and early January 2021.
Screening testing, i.e., testing of asymptomatic individuals, paired with enhanced infection
prevention and control (IPC), has been one of the primary strategies available to control
outbreaks in nursing homes, although the extent and frequency of testing has been hampered
by resource availability [3]. Current recommendations are to test previously undiagnosed
residents and staff every 3-7 days if there is an outbreak in the facility. Staff should be tested up
to twice weekly regardless of outbreak status, depending on community test positivity [4,5].
While both polymerase chain reaction (PCR) and antigen tests are used, we found in previous
work that point of care testing, such as antigen tests – which are less sensitive to detect any
virus RNA but nearly as sensitive for infectious virus – may better reduce transmission when
used at the same frequency. This is due largely to the rapid turnaround time for results [6,7].
The results of clinical trials of vaccines currently authorized in the United States show high
vaccine efficacy (VE) against symptomatic disease across all age groups, which is promising for
reducing morbidity and mortality among nursing home residents [8,9]. As of January 2021, over
100,000 residents, representing 19.5% of residents with confirmed infection, and over 1000 staff
have died [10]. While mortality rates will vary by age and other factors, the ability of the vaccine
to reduce symptomatic disease, especially severe symptoms, will have a substantial impact on
mortality.
The vaccine trials did not provide data on VE against all infection (i.e., including asymptomatic
infection) or infectiousness (e.g. ability to transmit virus to others, such as by blunting or
reducing the duration of peak viral load) [11]. The VE against infection and infectiousness have
important implications for understanding whether these vaccines can build herd immunity in a
population and for identifying when and to what extent other IPC strategies can be lifted. In
nursing homes, outbreak control measures take substantial resources and do have important
negative consequences—including restricting visitors and drawing on limited staff time.
Communities of color comprise a large proportion of nursing home staff [12,13]. Recent
analyses have found lower vaccination uptake among staff compared to residents [14–16]. This
may be due in part to hesitancy stemming from historical injustices that have justifiably resulted
in reduced trust in medicine and the safety of a novel vaccine [17].
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Here, we use mathematical modeling to examine at the effects of vaccination in nursing homes,
with the understanding that vaccination among the elderly in the general community will lag
behind vaccination in nursing homes. While vaccinating residents is a priority, we focus here on
the effects of increasing vaccination among staff, as high resident turnover makes it challenging
to maintain high vaccination levels among residents in the absence of high community
vaccination coverage. We also look at testing strategies under different assumptions about the
mode of VE to evaluate how, or whether, screening testing recommendations may be changed
following vaccine rollout.
Methods
Model overview
Here, we expand upon a previously developed stochastic, agent-based Susceptible–Exposed–
Infectious (Asymptomatic/Symptomatic)–Recovered (SEIR) model of SARS-CoV-2 transmission
in nursing homes [6]. Infected individuals are identified either based on symptoms or through
screening testing, after which they are isolated in a separate COVID-19 specific area of the
nursing home. Staff in the COVID-19 area are assumed to have access to personal protective
equipment. Resident lengths of stay are variable and drawn from a distribution based on data
from the publicly available Centers for Medicare and Medicaid Services Minimum Data Set 3.0
from 2016 [18] (Table S1); we made the simplifying assumption that the nursing home remains
at 100% capacity, with new residents replacing those who have died or been discharged. We
assume new resident admissions are not vaccinated or immune from previous infection,
reflecting low community vaccination coverage, but vary this in a sensitivity analysis (Table S1).
The nursing home consists of 100 residents, with two per room, and 100 staff who are assumed
to be split evenly across three shifts. Infected staff are not eligible to work, resulting in shortages
of staff in the nursing home; if staffing falls below 50%, temporary workers are brought in as
replacements. Aside from temporary workers, we assume that there is no staff turnover. We
assume residents do not contact other residents, with the exception of their roommates, and
daily contact rates between residents and staff are based on contact rates from nursing homes
across the United States [19,20].
Viral load is modeled stochastically for each infected individual [6]. Importantly, we assume that
viral load trajectories for asymptomatic and symptomatic infections are drawn from the same
parameter distributions [21,22]. We model infectiousness categorically, making the assumption
that it depends on viral load (i.e. number of RNA copies per mL) as follows: not infectious
(<10^4 copies/mL), moderately infectious, i.e., 50% of full infectiousness, and fully infectious
(>10^7 copies/mL). While the relationship between infectiousness and viral load is not fully
understood, these assumed values fall within the range used in other models [22]. This is likely
conservative as peak viral loads routinely exceed 10^10 copies/mL, and full infectiousness may
not be reached until viral loads are closer to this range.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Testing strategies
We evaluate two types of screening tests: 1) rapid antigen testing and 2) PCR testing,
simulating either weekly testing or testing every three days (2.3 times per week on average).
These testing scenarios are compared to a scenario where testing is only symptom-based, i.e.,
there is no screening testing of individuals who do not have symptoms. PCR and antigen tests
vary in their sensitivity (modeled as viral limit of detection (LOD)) and turnaround time. Based on
the data available on these tests, antigen testing has a higher LOD than PCR (Table S1) but
returns results immediately, whereas PCR here has a two day delay. For symptomatic
individuals, isolation begins immediately upon symptom onset, while for asymptomatic
individuals, isolation is not implemented until results are returned. While not explicitly modeled,
we assume high specificity of antigen tests would be achieved through rapid confirmatory tests.
To isolate the effects of the different vaccine scenarios in our analysis, everyone in the facility is
susceptible to infection at the beginning of each simulation and no cases are introduced into the
facility until 8 days after the second dose, after which staff have a daily probability of infection
from the community. In a sensitivity analysis, we examine the impact of allowing cases to be
introduced 8 days after the first dose. To identify the effects of vaccination among staff, 90% of
residents are vaccinated with two doses at baseline, and we only vary coverage among staff.
Our primary endpoint for each of these vaccine scenarios and testing strategies is cumulative
symptomatic infections after 40 days, using the mean across 100 simulations.
Results
As expected, we find that in each of the VE scenarios, increasing vaccination coverage among
staff reduces total symptomatic cases (i.e. among both residents and staff) (Figure 1). The
scenario with high VE against infection and infectiousness (Scenario 1) is most effective at
reducing total symptomatic cases. When the vaccine only protects against symptoms (Scenario
3), total symptomatic cases are highest within each level of staff vaccination coverage.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Figure 1. In each of the vaccine efficacy scenarios, increasing vaccination coverage among staff reduces
total symptomatic cases (i.e. combined symptomatic cases among residents and staff). Two dose
vaccinations are assumed to be completed before cases are able to be introduced into the facility starting
on day 0.
While increasing vaccination coverage among staff reduces overall symptomatic cases across
both staff and residents in all three scenarios, the impact of staff vaccination coverage on total
symptomatic cases in residents only is highly dependent on the type of vaccine efficacy (Figure
2). When the vaccine protects against infection and infectiousness, increasing vaccination
coverage among staff reduces symptomatic cases among residents. The importance of staff
vaccination to protect resident infections in these scenarios is likely due to low coverage among
residents. Although initial vaccine coverage is 90% in residents, there is high resident turnover
and low assumed community vaccination coverage, so the proportion of residents who are
vaccinated falls quickly. In a sensitivity analysis where 50% of incoming residents are assumed
to be vaccinated, the total number of symptomatic cases is lower, but staff coverage still
remains important for reducing cases among residents, and we see the same trends across
vaccine efficacy scenarios (Figures S1).
On the other hand, if the vaccine only protects against symptoms, higher coverage among staff
may increase the proportion of cases that are asymptomatic, leading to more undetected
transmission. This leads to higher total symptomatic cases among residents as staff coverage
increases (Figure 2, panel 3).
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Figure 2. When considering symptomatic cases in residents, increasing vaccination coverage among staff
from 0% reduces cases in vaccine scenarios 1 and 2, when vaccination confers at least low protection
against infection and infectiousness. When the vaccine protects against symptoms only, increasing
vaccination coverage among staff increases symptomatic cases among residents.
The importance of continued screening testing also varies by type of vaccine efficacy (Figure 3).
When the vaccine has partial or no efficacy against infections and infectiousness (Scenarios 2
and 3), more frequent screening testing reduces total symptomatic cases in residents. When VE
protects against symptoms only, the vaccine increases the proportion of asymptomatic
infections, while also failing to prevent infections and induce herd immunity; therefore, high
frequency of screening testing is particularly important for controlling disease spread. Due to
faster turnaround time, antigen testing results in lower incidence than PCR testing done at the
same frequency. If the vaccine has high efficacy against infection and infectiousness (Scenario
1), screening testing has little added benefit over symptom-based testing. In a sensitivity
analysis where cases are allowed to be introduced 8 days after the first dose (compared to 8
days after the second dose in our baseline scenario), we see that screening testing is important
for reducing outbreak size under all VE scenarios (Figure S4).
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Figure 3. The differences between testing strategies vary across vaccine efficacy scenarios. When the
vaccine has low or no efficacy against infections and infectiousness (Scenarios 2 and 3), frequent
screening testing is important for reducing total symptomatic cases in residents. Due to faster turnaround
time, antigen testing results in lower incidence than PCR testing at the same frequency.
Discussion
As vaccine program implementation continues in nursing homes and across the country,
understanding how well vaccines are able to reduce infection and infectiousness in addition to
symptomatic infection is critical for informing ongoing strategies to control COVID-19 outbreaks.
By modeling outbreaks within a single nursing home, we look at the impact of vaccination
coverage among staff and multiple testing strategies under different assumptions about vaccine
efficacy. We find that given high resident turnover in nursing home settings, staff vaccination
coverage is a critical factor driving outbreak size. Due to limited vaccine supply, vaccine
program implementation will likely continue to be targeted based on risk for some period; in this
paper we focus on this period in which vaccines are available but are not yet being offered to
the community at large.
We find that increasing vaccination coverage among staff can have a protective effect for
residents if the vaccine provides at least some protection against infection and infectiousness.
These results highlight the importance of encouraging vaccination among staff—both for their
protection, as they have been one of the groups most severely affected to date, and also to
protect residents, who are among those at highest risk of mortality. Efforts to increase staff
vaccination should include culturally competent messaging and support to address the concerns
of nursing home staff. Reaching higher vaccine coverage among staff could allow for less
screening testing, as we see that increased frequency of testing has little added benefit when
efficacy against infection is high.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
If the vaccine does not protect against infection and infectiousness, but only against symptoms,
our analysis indicates that increasing staff coverage might lead to higher numbers of
symptomatic cases among residents. These results underscore the importance of continuing to
provide frequent screening testing in nursing homes, particularly during outbreaks, until more
data are available on the types and extent of protection the vaccines provide. Given the
importance of rapid results, we see that point of care tests, such as antigen tests, may be more
effective than PCR tests in reducing outbreak size, particularly in areas that do not have access
to rapid PCR test results. Newer high sensitivity PCR-quality rapid tests like rapid loop-mediated
isothermal amplification (LAMP) assays may become available soon, which would provide
speed and accessibility without compromising sensitivity.
An important driver of the results from this model is relatively low vaccine coverage among
residents, even after high coverage during initial vaccine rollout, due to the assumptions of high
resident turnover and low community vaccination rates. Once community vaccination coverage
is high enough that most incoming residents are already protected, the impact of staff coverage
and the importance of testing symptomatic cases in residents will diminish. However, due to the
timing and challenges with vaccine rollout so far in many areas and low seroprevalence in older
age groups [23], reaching these levels will likely take many months.
We have made simplifying assumptions about the logistics of vaccine rollout, with only two days
for vaccination (one for each dose). Many nursing homes conducted vaccinations across three
days, and in the future residents may be offered vaccination upon admission to the nursing
homes, which would help maintain high levels of resident vaccination coverage in the short-
term. Given the two-dose schedule, many residents will not stay long enough to see the effects
of both doses, or even get a second dose, even if opportunities for vaccination are provided
during their stay (Table S1). This underscores the importance of continuing to vaccinate
community-dwelling individuals (e.g., older adults, those with multiple comorbidities) before they
become nursing home residents to ensure that short-stay residents are protected. We have also
made several assumptions regarding contact patterns, including modeling staff as one
population; in reality, nursing homes employ many different types of staff who have different
responsibilities and levels of interaction with residents that affect risk of transmission. We made
the conservative assumption of equal infectiousness given vaccination status for asymptomatic
and symptomatic infections. We also did not specifically assess the potential benefits of
outbreak vs non-outbreak testing in a vaccinated population, which may have important
implications for prioritizing limited testing resources; we focus on screening testing in this
analysis. We further assume nursing homes will maintain strict policies limiting visitation and
socializing within the facility over the simulation’s time horizon. These policies have important
implications for quality of life and have been one of the major challenges for nursing home
residents during the pandemic. Future research is needed to explore the impact of vaccine
efficacy, testing practices, and community incidence rates on the ability to safely relax these and
other IPC policies.
Data from vaccine rollout in nursing homes and other settings prioritized for early vaccination
have the potential to improve our understanding of the mode(s) and level of vaccine efficacy.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
These data may also provide insight into the efficacy of these vaccines against new variants of
concern. Until there is sufficient evidence indicating the extent of efficacy against infection or
infectiousness, screening testing remains a key tool for mitigating outbreaks in these high-risk
settings, and frequent testing should continue to be conducted to prevent nursing home
outbreaks [24].
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Acknowledgements
We thank Matt Samore for helpful discussion.
Funding
RK and MJM were supported by NCI U01: U01 CA261277. RK was supported by MInD: U01
CK000585. MJM was supported by Open Philanthropy.
Conflicts of Interest
MJM has received ad hoc speaking fees from Abbott Diagnostics and Roche Diagnostics. RK
has received consulting fees from Partners In Health.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
References
1. The New York Times. More Than One-Third of U.S. Coronavirus Deaths Are Linked to
Nursing Homes. The New York Times. Jun 27, 2020, updated Feb 2, 2021; Available
at: https://www.nytimes.com/interactive/2020/us/coronavirus-nursing-homes.html.
2. Dooling K, McClung N, Chamberland M, et al. The Advisory Committee on
Immunization Practices’ Interim Recommendation for Allocating Initial Supplies of
COVID-19 Vaccine - United States, 2020. MMWR Morb Mortal Wkly Rep 2020;
69:1857–1859.
3. Front-line Nursing Home Staff Experiences During the COVID-19 Pandemic. J Am Med
Dir Assoc 2021; 22:199–203.
4. CMS. Memorandum QSO-20-38-NH. Aug 26, 2020. Available at:
https://www.cms.gov/files/document/qso-20-38-nh.pdf.
5. CDC. Testing Guidelines for Nursing Homes. 2021. Available at:
https://www.cdc.gov/coronavirus/2019-ncov/hcp/nursing-homes-testing.html. Accessed
25 January 2021.
6. Holmdahl I, Kahn R, Hay J, Buckee CO, Mina M. Frequent testing and immunity-based
staffing will help mitigate outbreaks in nursing home settings. medRxiv 2020;
:2020.11.04.20224758.
7. See I, Paul P, Slayton RB, et al. Modeling effectiveness of testing strategies to prevent
COVID-19 in nursing homes —United States, 2020. medRxiv 2020;
:2020.12.18.20248255.
8. Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-
CoV-2 Vaccine. N Engl J Med 2020; Available at:
http://dx.doi.org/10.1056/NEJMoa2035389.
9. Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA
Covid-19 Vaccine. N Engl J Med 2020; 383:2603–2615.
10. COVID-19 Nursing Home Data. Available at: https://data.cms.gov/stories/s/COVID-19-
Nursing-Home-Data/bkwz-xpvg/. Accessed 25 January 2021.
11. Elizabeth Halloran M, Longini IM Jr, Struchiner CJ. Design and Analysis of Vaccine
Studies. Springer Science & Business Media, 2009.
12. PHI National. U.S. Nursing Assistants Employed in Nursing Homes: Key Facts.
Available at: https://phinational.org/wp-content/uploads/legacy/phi-nursing-assistants-
key-facts.pdf.
13. Khimm S. The forgotten front line: Nursing home workers say they face retaliation for
reporting COVID-19 risks. 2020. Available at: https://www.nbcnews.com/news/us-
news/forgotten-front-line-nursing-home-workers-say-they-face-retaliation-n1209606.
Accessed 17 January 2021.
14. Bernard Condon MS. Vaccine rollout hits snag as health workers balk at shots. 2021.
Available at: https://apnews.com/article/coronavirus-vaccine-health-workers-
676e03a99badfd5ce3a6cfafe383f6af. Accessed 17 January 2021.
15. Shalby C, Baumgaertner E, Branson-Potts H, Reyes-Velarde A, Dolan J. Some
healthcare workers refuse to take COVID-19 vaccine, even with priority access. Los
Angeles Times. 2020; Available at: https://www.latimes.com/california/story/2020-12-
31/healthcare-workers-refuse-covid-19-vaccine-access. Accessed 17 January 2021.
16. Gharpure R. Early COVID-19 First-Dose Vaccination Coverage Among Residents and
Staff Members of Skilled Nursing Facilities Participating in the Pharmacy Partnership for
Long-Term Care Program — United States, December 2020–January 2021. MMWR
Morb Mortal Wkly Rep 2021; 70. Available at:
https://www.cdc.gov/mmwr/volumes/70/wr/mm7005e2.htm. Accessed 1 February 2021.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
17. Bassett MT. #BlackLivesMatter--a challenge to the medical and public health
communities. N Engl J Med 2015; 372:1085–1087.
18. Minimum Data Set 3.0 Public Reports. Available at: https://www.cms.gov/Research-
Statistics-Data-and-Systems/Computer-Data-and-Systems/Minimum-Data-Set-3-0-
Public-Reports. Accessed 18 January 2021.
19. Anglo R. Chief Clinical Officer, Chelsea Jewish Life Care, Personal communication, Jun
10, 2020.
20. Samore M. Professor of Internal Medicine, University of Utah. Personal communication,
Dec 08, 2020.
21. Kissler SM, Fauver JR, Mack C, et al. SARS-CoV-2 Viral Dynamics in Acute Infections.
medRxiv. 2020; Available at:
https://www.medrxiv.org/content/10.1101/2020.10.21.20217042v2.
22. Larremore DB, Wilder B, Lester E, et al. Test sensitivity is secondary to frequency and
turnaround time for COVID-19 screening. Science Advances 2021; 7:eabd5393.
23. Bajema KL, Wiegand RE, Cuffe K, et al. Estimated SARS-CoV-2 Seroprevalence in the
US as of September 2020. JAMA Intern Med 2020; Available at:
http://dx.doi.org/10.1001/jamainternmed.2020.7976.
24. CDC. Responding to Coronavirus (COVID-19) in Nursing Homes. 2020. Available at:
https://www.cdc.gov/coronavirus/2019-ncov/hcp/nursing-homes-responding.html.
Accessed 19 February 2021.
25. Bar-On YM, Flamholz A, Phillips R, Milo R. SARS-CoV-2 (COVID-19) by the numbers.
Elife 2020; 9. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224694/.
Accessed 27 September 2020.
26. Oran DP, Topol EJ. Prevalence of Asymptomatic SARS-CoV-2 Infection : A Narrative
Review. Ann Intern Med 2020; 173:362–367.
27. Johansson MA, Quandelacy TM, Kada S, et al. SARS-CoV-2 Transmission From
People Without COVID-19 Symptoms. JAMA Netw Open 2021; 4:e2035057–e2035057.
28. CDC. Healthcare Workers. 2020. Available at: https://www.cdc.gov/coronavirus/2019-
ncov/hcp/planning-scenarios.html. Accessed 17 January 2021.
29. Lennon NJ, Bhattacharyya RP, Mina MJ, et al. Comparison of viral levels in individuals
with or without symptoms at time of COVID-19 testing among 32,480 residents and staff
of nursing homes and assisted living facilities in Massachusetts. Public and Global
Health. 2020; Available at:
https://www.medrxiv.org/content/10.1101/2020.07.20.20157792v1.abstract.
30. Byambasuren O, Cardona M, Bell K, Clark J, McLaws M-L, Glasziou P. Estimating the
extent of asymptomatic COVID-19 and its potential for community transmission:
systematic review and meta-analysis. Available at:
http://dx.doi.org/10.1101/2020.05.10.20097543.
31. Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel
Coronavirus-Infected Pneumonia. N Engl J Med 2020; 382:1199–1207.
32. Livingston E, Desai A, Berkwits M. Sourcing Personal Protective Equipment During the
COVID-19 Pandemic. JAMA 2020; 323:1912–1914.
33. Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized
patients with COVID-2019. Nature 2020; 581:465–469.
34. Butler DJ, Mozsary C, Meydan C, et al. Shotgun Transcriptome and Isothermal Profiling
of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and
Drug Interactions. bioRxiv 2020; Available at:
http://dx.doi.org/10.1101/2020.04.20.048066.
35. Dao Thi VL, Herbst K, Boerner K, et al. A colorimetric RT-LAMP assay and LAMP-
sequencing for detecting SARS-CoV-2 RNA in clinical samples. Sci Transl Med 2020;
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Supplementary Materials
Supplemental Figure 1.
Figure S1. Dotted lines show original simulations from Figure 1 with no vaccination in the community.
Solid lines show means of simulations done with 50% of incoming residents already vaccinated.
Supplemental Figure 2.
Figure S2. Effect of staff vaccination when 50% of incoming residents are vaccinated. When considering
symptomatic cases in residents, increasing vaccination coverage among staff from 0% reduces cases in
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
vaccine scenarios 1 and 2, when vaccination confers at least low protection against infection and
infectiousness. When the vaccine protects against symptoms only, increasing vaccination coverage
among staff increases symptomatic cases among residents.
Supplemental Figure 3.
Figure S3. Effect of testing when 50% of incoming residents are vaccinated. When the vaccine has low or
no efficacy against infections and infectiousness (Scenarios 2 and 3), frequent screening testing is
important for reducing total symptomatic cases in residents. Due to faster turnaround time, antigen testing
results in lower incidence than PCR testing at the same frequency.
Supplemental Figure 4.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.26.21252483; this version posted March 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available
for use under a CC0 license.
Figure S4. When cases are allowed to be introduced 8 days after the first vaccine dose (vs. 8 days after
the second dose in Figure 3), we see that testing remains more important for controlling outbreak size
under all VE scenarios. Here, the second dose is administered on day 13, and takes effect on day 20.
Length of stay 25th, 50th, 75th percentiles, after restricting to minimum 15, 27, 66 [18,38]
of 7 days (days)
*If no reference is cited, parameters are assumed.