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Human Water and Electrolyte Balance
Human Water and Electrolyte Balance
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33
Human Water and
Electrolyte Balance
body water, respectively. The ECF is further divided into and diuretic use are different, but any difference between
the interstitial and plasma spaces. Water balance repre- active and passive sweating remains unresolved. Other
sents the net difference between water intake and loss. factors such as heat acclimatization status, posture,
When losses exceed intakes, total body water is decreased. climate, mode, and intensity of exercise can also pro-
When body water deficits occur from sweat losses, a duce significant variability in the responses described
hypertonic hypovolemia generally results. Plasma volume above.21,22
decreases and plasma osmotic pressure increases in pro-
portion to the decrease in total body water. Plasma vol-
ume decreases because it provides the fluid for sweat, and
Water and Electrolyte Needs
osmolality increases because sweat is ordinarily hypotonic Human water and electrolyte needs should not be
relative to plasma. Resting plasma osmolality increases in based on a “minimal” intake, as this might eventually lead
a linear manner from about 283 mosmol/kg when euhy- to a deficit and possible adverse performance and health
drated, to more than 300 mosmol/kg when hypohydrated consequences. Instead, the Food and Nutrition Board of
by 15% of total body water.1 The increase in osmotic the Institute of Medicine bases water needs on Adequate
pressure is primarily due to increased plasma sodium and Intake (AI). The AI is based on experimentally derived
chloride. with no consistent effect on potassium concen- intake levels that are expected to meet nutritional ade-
trations.10-12 quacy for essentially all members of a healthy population.
Incomplete fluid replacement decreases total body The AI level for water is 2.7 to 3.7 L/d for sedentary
water, and as a consequence of free fluid exchange, affects women and men over age 19, respectively.1 These values
each fluid space.13-16 For example, Nose et al.15 deter- represent total water intake from all fluids (80%) and
mined the distribution of body water loss among fluid foods (20%). The AI for sodium is 1.5 g/d or 3.8 g/d
spaces as well as among different body organs during hy- sodium chloride.1 The report also indicates that athletes
pohydration. They thermally dehydrated rats by 10% of and workers performing stressful exercise in the heat can
body weight, and after the animals regained their normal exceed the AI for water and sodium.
core temperature, the body water measurements were ob- Table 123 illustrates the wide variability in hourly sweat
tained. The fluid deficit was apportioned between the losses observed both within and between sports and occu-
intracellular (41%) and extracellular (59%) spaces. Re- pations. Depending upon the duration of activity and heat
garding organ fluid loss, 40% came from muscle, 30% stress exposure, the impact of these elevated hourly sweat
from skin, 14% from viscera, and 14% from bone. Neither rates on daily water requirements will vary. Figure 1 de-
the brain nor liver lost significant water content. They picts generalized modeling approximations for daily water
concluded that hypohydration results in water redistribu- requirements based upon calculated sweating rates as a
tion largely from the intra- and extracellular spaces of function of daily energy expenditure (activity level) and
muscle and skin in order to maintain blood volume. air temperature.1 Applying this prediction model, it is
Different methods of dehydration are known or sus- clear that daily water requirements can increase two- to
pected to affect the partitioning of body water losses dif- six-fold from baseline by simple manipulation of either
ferently than those just described. For example, diuretics variable. For example, daily water requirements for any
increase urine formation and generally result in the loss of given energy expenditure in temperate climates (20⬚C)
both solutes and water. Diuretic-induced hypohydration can triple in very hot weather (40⬚C). In addition to air
generally results in an iso-osmotic hypovolemia, with a temperature, other environmental factors also modify
much greater ratio of plasma loss to body water loss than sweat losses; these include relative humidity, air motion,
either exercise or heat-induced hypohydration.10,17 As a solar load, and choice of clothing for protection against
result, relatively less intracellular fluid is lost after diuretic
administration, since there is not an extracellular solute
excess to stimulate redistribution of body water. In con- Table 1. Sweating Rates for Different Sports (Data
trast, several studies13,18,19 report substantial decreases in are from Rehrer N, Burke L. Sweat losses during
skeletal muscle intracellular water content following pro- various sports. Aust J Nutr Diet. 1996;53:
longed exercise without fluid replacement, presumably S13–S16.)
the result of water released with the breakdown of muscle Mean Range
glycogen. Exercise-induced hypohydration may therefore
result in a greater intracellular water loss than simple Sport L/h
sweat-induced hypohydration (passive thermal dehydra-
tion). Kozlowski and Saltin20 reported data to support Water polo 0.55 0.30–0.80
this view, but Costill and Saltin18 found no difference Cycling 0.80 0.29–1.25
between exercise and thermal dehydration for the parti- Running 1.10 0.54–1.83
tioning of water between the fluid compartments. It is Basketball 1.11 0.70–1.60
therefore clear that the ratio of intracellular to extracellu-
Soccer 1.17 0.70–2.10
lar water losses that occur with dehydration from sweating
Average Daytime Dry Bulb Temperature (oF) Average Daytime Dry Bulb Temperature (oF)
59 68 77 86 95 104 59 68 77 86 95 104
14 10000
3600 Kcal/day
12 3600 Kcal/day
8000 2900 Kcal/day
10
2900 Kcal/day 2400 Kcal/day
8 6000
2400 Kcal/day
1900 Kcal/day
6 1900 Kcal/day
4000
2000
2
Average Daytime Dry Bulb Temperature (oC) Average Daytime Dry Bulb Temperature (oC)
Figure 1. Daily water needs estimated from sweat loss predictions Figure 2. Daily sodium needs estimated from sweat loss predic-
due to changes in physical activity and air temperature. Daily en- tions due to changes in physical activity and air temperature. Daily
ergy expenditures of 1900, 2400, 2900 and 3600 kcal correspond energy expenditures of 1900, 2400, 2900, and 3600 kcal corre-
to sedentary, low activity, active, and very active, respectively. spond to sedentary, low activity, active, and very active, respec-
(From Food and Nutrition Board, Institute of Medicine. Dietary tively. (From Food and Nutrition Board, Institute of Medicine. Di-
Reference Intakes for Water, Potassium, Sodium, Chloride, and etary Reference Intakes for Water, Potassium, Sodium, Chloride,
Sulfate. Washington, DC: National Academies Press; 2004. Avail- and Sulfate. Washington, DC: National Academies Press; 2004.
able online at: http://www.nap.edu/books/0309091691/html.) Available online at: http://www.nap.edu/books/0309091691/html.)
environmental elements.24 Therefore, it is expected that covers the additional sodium required.1 Therefore, so-
water losses, and therefore water needs, will vary consid- dium supplementation is generally not necessary (unless
erably among moderately active people based on changing subjects are performing very heavy activity) for the first
extraneous influences. several days of heat exposure, as normal dietary sodium
Sweat is hypotonic to extracellular fluid, but contains intake appears adequate to compensate for sweat sodium
electrolytes, primarily sodium chloride and, to a lesser losses.2,32 If persons need additional sodium, this can be
extent, potassium, calcium, and magnesium.25-27 Sweat achieved by salting their food to taste. Another strategy
sodium concentration averages 35 mEq/L (range 10–70 is to rehydrate with fluids containing about 20 mEq/L
mEq /L) and varies depending upon diet, sweating rate, of sodium. Most commercial sports beverages approxi-
hydration level, and heat acclimation state.25,28,29 Sweat mate this concentration.2,32
potassium concentration averages 5 mEq/L (range 3–15
mEq /L), calcium 1 mEq/L (range 0.3–2 mEq/L), mag-
nesium 0.8 mEq /L (range 0.2–1.5 mEq /L), and chloride
Hydration Assessment
30 mEq/L (range 5–60 mEq/L).29 Neither gender nor Although plasma osmolality is the criterion used as the
aging seem to have marked effects on sweat electrolyte hydration assessment measure for large-scale fluid needs
concentrations.30,31 Sweat glands reabsorb sodium by ac- assessment surveys,1 the optimal choice of method for
tive transport, but the ability to reabsorb sweat sodium assessing hydration, particularly in sport, is limited by the
does not increase proportionally with the sweating rate. circumstances and intent of the measurement. Popular
As a result, the concentration of sweat sodium increases hydration assessment techniques vary greatly in their ap-
at high sweating rates.25,28 Heat acclimation improves the plicability to laboratory or field use due to methodological
ability to reabsorb sodium, so heat-acclimated persons limitations, which include the necessary circumstances for
have lower sweat sodium concentrations (⬎50% reduc- accurate measurement, ease of application, and sensitivity
tion) for any given sweating rate.28 for detecting small, but meaningful changes in hydration
Figure 2 depicts generalized modeling approximations status.33
for daily sodium needs based upon calculated sweating Although there is presently no consensus for using
rates as a function of daily energy expenditure (activity one assessment approach over another, in most athletic
level) and air temperature.1 This analysis assumes that arenas, the use of first morning body mass measurements
persons are heat acclimated and have a sweat sodium con- in combination with some measure of urine concentration
centration of 25 mEq/L (about 0.6 g/L). The average should allow ample sensitivity (low false negative) for de-
American diet contains about 4 g/d of sodium,1 but this tecting deviations in fluid balance. When more precision
varies greatly depending upon ethnic preferences for food. of acute hydration changes is desired, plasma osmolality
Increases or decreases in sodium stores are usually cor- and isotope dilution provide for gradations in measure-
rected by adjustments in a person’s salt appetite. In addi- ment.33 However, the simplest way to track acute hydra-
tion, when physical activity increases, the additional ca- tion changes is to measure body mass before and after
loric intake associated with increased activity usually exercise using the reasonable assumption that 1 g of lost
mass is equivalent to 1 mL of lost fluid. In fact, if proper dry heat loss during exercise depend upon the specific
controls are made, body mass changes can provide a more environmental conditions,50 but both avenues of heat loss
sensitive estimate of acute total body water changes than are adversely affected by hypohydration.1 Local sweating
repeat measurements by dilution methods.34 For longer and skin blood flow responses are both reduced for a given
periods (1–2-weeks), body mass may even remain stable core temperature,46,48 and whole-body sweating is usually
enough to be a reliable hydration measure during periods either reduced51 or unchanged52 during exercise at a given
of hard exercise and acute fluid flux whether in temper- metabolic rate in the heat. However, even when hypohy-
ate35,36 or hot37 climates. Table 2 provides definable dration is associated with no change in whole-body
thresholds from the literature,1,37-43 which can be used sweating rate, core temperature is usually elevated, so that
as a guide to detect a negative body fluid balance. Fluid whole-body sweating rate for a given core temperature is
intakes should be considered adequate when any two as- lower. Both the singular and combined effects of plasma
sessment outcomes are consistent with euhydration. hyperosmolality and hypovolemia have been suggested as
mediating the reduced heat loss response during exercise-
heat stress.48 Figure 3 summarizes the relative contribu-
Fluid Balance, Temperature tions of hyperosmolality and hypovolemia to adverse ther-
Regulation, and Exercise moregulatory responses during exercise in temperate and
Performance hot climates.48 These effects are noticeably smaller in
cooler environments.48,53,54
The difficulty encountered when trying to match fluid Hypohydration can decrease dynamic exercise perfor-
consumption to sweat losses during exercise can produce mance.1 Dehydration by more than 2% of body weight
hypohydration by 2% to 6% of body weight.44 Although degrades endurance exercise, especially in hot environ-
this is more common in hot environments, similar losses ments.1,55 The magnitude of the performance decrement
are observed in cold climates when working in heavy is variable, and probably depends on the individual, on
clothing.45 The mismatch between intakes and losses is environmental conditions, and on exercise mode differ-
due to physiological and behavioral factors. ences. However, for a given person and event, the greater
the dehydration level (after achieving the threshold for
Hypohydration performance degradation) the greater the performance
Hypohydration increases core temperature responses
during exercise in temperate and hot climates.46 In fact,
a deficit of only 1% of body weight elevates core tempera-
ture during exercise.47 As the magnitude of water deficit
increases, the magnitude of core temperature elevation
ranges from 0.1 to 0.23⬚C for every percent body weight
lost,1,46 but the core temperature elevation may be greater
during exercise in hot compared with temperate cli-
mates.48 In addition, altering the time of fluid ingestion
(early or late into the exercise bout) does not modify the
core temperature elevation from progressive dehydra-
tion.49 Hypohydration not only elevates core temperature,
but also negates the core temperature advantages con- Figure 3. Effects of reducing total body water (TBW) on sweating
ferred by high aerobic fitness and heat acclimation.46 (S) and skin blood flow (F) thresholds and sensitivities. Substan-
When hypohydrated, elevated core temperature re- tial, moderate, and limited descriptors are based on amount of
supporting data. (From Cheuvront SN, Carter III R, Montain SJ,
sponses result from a reduction in the capacity for heat et al. Influence of hydration and airflow on thermoregulatory con-
dissipation. The relative contributions of evaporative and trol in the heat. J Therm Biol. 2004;29:471–477.)
those of the authors and should not be construed as an water losses among fluid compartments of tissues
official Department of the Army position, or decision, under thermal dehydration in the rat. Jpn J Physiol.
unless so designated by other official documentation. Ap- 1983;33:1019–1029.
proved for public release; distribution unlimited. 16. Singh MV, Rawal SB, Pichan G, Tyagi AK.
Changes in body fluid compartments during hypohy-
dration and rehydration in heat-acclimated tropical
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