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TDM of Digoxin
TDM of Digoxin
Atiqulla Shariff
Drug profile
Indications of drug
Dose
Loading dose is 10-15 mcg/kg/day in 3 divided doses
Maintenance dose is 0.125- 0.5 mg/day
• This doses is in normal renal function
• In renal failure the frequency of administration has to be
altered and has to be adjusted every 3-5 days.
Indications for TDM
Tubing:
Drug Interactions:
Patient compliance
Error in dosage regimen
Poor bioavailability
Rapid elimination of drug
Increased VOD
SSC may not be reached
Timing of blood sampling
If the SDC is higher than anticipated
Patient compliance
Error in dosage regimen
Increased bioavailability
Smaller VOD
Slow elimination of drug