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30185-Article Text-56577-1-10-20220411
30185-Article Text-56577-1-10-20220411
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ABSTRACT
Background: The phenomenon of Coronary Slow Flow (CSF) is an angiographic clinical verity,
which is characterized by late opacification of the distal segments of the coronary artery without
having significant stenosis. However, a definite and reliable mechanism of CSF is still not known.
Short-chain fatty acids (SCFA) such as acetate, butyrate, and propionate are produced as a result
of the fermentation of indigestible dietary fibers in the gut by the microbiota. Many studies have
investigated the role of SCFA as a related signaling pathway in inflammation, glucose metabolism,
and lipid metabolism. In this study, we investigated the correlation between Short Chain Fatty
Acids and Lipid Profile serum in Patients with Slow Flow Coroner.
Materials and Methods: A cross sectional study was conducted at dr. Zainoel Abidin Hospital of
Banda Aceh. All consecutive patients scheduled for coronary angiography between July 2021 to
Desember 2021. CSF was diagnosed based on the Thrombolysis In Myocardial Infarction (TIMI)
frame count (TFC) of coronary flow. Data was obtained through laboratory examination and stool
samples. Stool samples were analyzed for SCFA (acetate, propionate, and butyrate acids) with
gas chromatography.
Results: The results of the present study indicate that SCFA, acetate, propionate, and valerate did
not show a significant correlation with lipid profile (P>0.05). The level of fecal butyrate was
negatively correlated with HDL (p=<0.05; r = -0.532).
Conclusions: Our study indicated that the level of butyrate was a moderate negative correlated
with HDL inpatient with slow flow coroner.
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Adewiah et al.; AJCR, 6(4): 5-10, 2022; Article no.AJCR.85867
Fig. 1. A negative correlation between butyrate acids with High-density Lipoprotein (HDL)
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Adewiah et al.; AJCR, 6(4): 5-10, 2022; Article no.AJCR.85867
Table 2. The associations between short-chain fatty acids (SCFAs) with Lipid Profile
TC LDL HDL TG
r (P value) r (P value) r (P value) r (P value)
Acetate Acids 0.063(0.823) 0.168(0.55) 0.325(0.237) 0.331(0.228)
Propionate Acids 0.081(0.773) -0.327(0.234) 0.003(0.992) -0.472(0.076)
Butyrate Acids -0,230 (0.410) -0.188(0.503) -0.532(0.041)* -0.033(0.907)
Valerate Acids -0.135(0.631) -0.026(0.926) -0.275(0.321) 0.409(0.130)
Absolute Butyrate Acids -0.280(0.312) -0.437(0.103) -0.1(0.722) -0.394(0.146)
Total SCFAs -0.108(0.701) -0.354(0.196) 0.379(0.163) -0.506(0.055)
*: p value correlation is significant at 0.05 level, r: Pearson’s correlation coefficient
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Adewiah et al.; AJCR, 6(4): 5-10, 2022; Article no.AJCR.85867
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Adewiah et al.; AJCR, 6(4): 5-10, 2022; Article no.AJCR.85867
© 2022 Adewiah et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited.
Peer-review history:
The peer review history for this paper can be accessed here:
https://www.sdiarticle5.com/review-history/85867
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