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    17 views4 pages

    Mucosta Drug Interactions - MIMS Malaysia

    Uploaded by

    Esy L

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    of 4

    8/3/22, 5:43 PM Mucosta Drug Interactions | MIMS Malaysia

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    Mucosta

    Mucosta Drug Interactions


    rebamipide
    Manufacturer:

    https://www.mims.com/malaysia/drug/info/mucosta/drug-interactions 2/4
    8/3/22, 5:43 PM Mucosta Drug Interactions | MIMS Malaysia
    Otsuka

    Distributor:

    Zuellig Pharma

    Marketer:

    A. Menarini

    SELECT
          Drug Interactions
    Concise Prescribing Info
    Full Prescribing Info
          Contents
          Description
          Action
          Indications/Uses
          Dosage/Direction for Use
          Overdosage
          Contraindications
          Special Precautions
          Use In Pregnancy & Lactation
          Adverse Reactions
          Drug Interactions
          Caution For Usage
          Storage
          MIMS Class
          ATC Classification
          Regulatory Classification
          Presentation/Packing
    Concise Prescribing Info
    Full Prescribing Info
    Contents Description Action Indications/Uses Dosage/Direction for Use
    Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions
    Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing
    Full Prescribing Info
    Drug Interactions
    Rebamipide had little inhibitory effect on cytochrome P450 enzymes in vitro. Rebamipide is hardly metabolized in the
    liver and excreted in urine as an unchanged compound; thus, the drug has not much influence on metabolization of
    other drugs. Regarding the concomitant administration with other drugs with higher protein binding rats (H2 blocker
    and Warfarin), although Mucosta (rebamipide) has a high protein binding rate (95% or more), its blood concentration
    is as low as up to 200 ng/mL; therefore, this drug is considered less likely to increase the blood concentration in
    competition with other drugs. In addition, there have been reports that Mucosta (rebamipide) has not been influenced
    by (1) plasma salicylic acid concentration (human) at the time of aspirin administration, (2) serum indomethacin
    concentration (human) at the time of indomethacin administration, and (3) plasma and tumor tissue 5-FU
    concentration (rat) at the time of UFT administration. No drug interactions between rebamipide and other drugs are
    reported.

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