Therapy of Worm Infestation
Therapy of Worm Infestation
Therapy of Worm Infestation
Vermicide (kill)
Vermifuge (expel)
It is a benzimidazole introduced in 1972.
Filariasis:
Albendazole added to diethylcarbamazin (DEC) or
ivermectin
It was introduced in 1969 for pin worm infestation in
children; use soon extended to roundworm and
hookworm as well.
MOA:
hyperpolarization of Ascaris muscle by a GABA agonistic
action.
Opening of Cl¯ channels causes relaxation and depresses
responsiveness to contractile action of ACh.
Diethylcarbamazine is microfilaricidal.
Albendazole is cheaper
For patients with seizure adequate anticonvulsant
treatment should be given beforehand and the fits
controlled.
Phenytoin and carbamazepine are the most commonly
used drugs