Smileanalysis: Diagnosis and Treatment Planning
Smileanalysis: Diagnosis and Treatment Planning
Smileanalysis: Diagnosis and Treatment Planning
KEYWORDS
Diastemas Maxillary Orthodontics Smile Smile Design
Interdisciplinary Treatment Planning Lip Gingiva Smile Arc Facial flow
Airway Global Diagnosis FGTP Digital Smile Design
INTRODUCTION
The Power of a Smile
“Even the simulation of an emotion tends to arouse it in our minds.”1 Charles Darwin
was the first to explain the hidden power of a smile. In his Facial-Feedback hypothesis,
he suggests that a smile has a systematically positive effect on the mind and body. A
widely cited 30-year longitudinal study on the analysis of smile expression in women’s
college pictures revealed that women displaying positive emotions in pictures had
favorable outcomes in their marriages and well-being and had more favorable person-
alities.2 Another study found that people with new smiles altered by cosmetic dentistry
were regarded as more attractive, intelligent, interesting, and wealthier.3 The power of
the smile is clearly exponential, and we are the architects of the new smile.
What Is Smile Design?
Smile design is defined as the process of creating an esthetic smile based on scientific
and artistic guidelines established through studies, perception, and cultural and racial
standards that have been recognized over time.4 Smile design is a dynamic field with
evolving trends that take into consideration: facial esthetics, lip dynamics, pink and
white esthetics, and personality. Traditional smile design focused on the orodental
complex. Modern smile designers must have a global understanding of the entire pa-
tient to design the perfect smile. Subjectivity is fundamental when it comes to smile
design. Purely scientific smiles are generic, symmetric, and seem fake. Copying and
pasting the same smile using the same tooth library and gingival esthetics for each pa-
tient results in an unesthetic result. No 2 smiles are identical, and each smile must take
on an identity of its own based on the guidelines outlined later. In the era of social me-
dia, it is popular for dentists to showcase artificial smiles. What sets a beautiful smile
apart is the integration of organic guidelines to achieve “perfect” results. In essence,
embracing nature and its imperfections is the next level of smile design (Fig. 1).
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Fig. 1. Natural and artificial smiles created by restorative dentistry. Natural smiles (A). Nat-
ural smile (B). Artificial smiles (C). Artificial smile (D).
Fig. 2. Different types of smile: commissure smile, social smile, and spontaneous smile.
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Smile Analysis 309
smile and should not be used. It is challenging to get a patient in a dental chair to
reproduce a spontaneous smile. Therefore, the recommendation is to film the patient
in a nontreatment room with a relaxed ambiance. Several frames are cropped from the
video to provide dynamic data of the patient’s smile.6 Failure to recognize the spon-
taneous smile can lead to incorrect diagnosis and catastrophic failure.
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Fig. 4. Facial proportions: middle to lower third ideally is 1:1. A longer lower third is diag-
nosed as VME (patient consent). This patient’s middle third measures at 64 mm and lower
third is 74 mm.
facial flow concept that states that due to the natural asymmetry of the hu-
man face, it is impossible to define a straight line as the midline. Rather, a
curved line connecting facial landmarks is more acceptable.12 The relation-
ship of the dental midline with the facial flow is discussed later in this article.
b. Profile view
i. Reference lines (Fig. 6)
1. The Frankfort horizontal, which is defined as a straight line from the highest
point on the margin of the auditory meatus to the lowest point of the orbit,
should be parallel to the horizon when the patient is in NHP.13
2. Camper’s plane or Ala-Tragus line, which is a line running from the inferior
border of the ala to the superior border of the tragus of the ear, determines
the maxillary occlusal plane.13,14 Different systems have shown reliability
in reproducing the maxillary occlusal plane, such as the Kois Dento-
Facial Analyzer, virtual face-bows, and the Behrend system that relies
on the use of photographs to determine tooth position and is the prototype
of Digital Smile Design (DSD).15
GLABELLA
CHIN
Facial flow
Fig. 5. Facial reference lines: the interpupillary line, the commissural line, and the facial
flow line as shown in the figure.
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Smile Analysis 311
Fig. 6. Profile reference lines. The Frankfort horizontal, Camper line, nasiolabial angle, and
E-Line are all important in smile design. (From Levine JB, Finkel S. Smile Design Integrating
Esthetics and Function. Vol Volume Two. (Levine JB, ed.). ELSEVIER; 2016.)
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312 Sabbah
excessive incisal display and a possible gummy smile and can be treated by
Botox.7
c. Lip mobility Fig. 9: upper lip mobility is defined as the amount of lip movement in
a full smile; this can be measured by subtracting incisal exposure at rest from
dentogingival exposure during a spontaneous smile or by subtracting lip length
in a spontaneous smile from lip length in repose.22 Normal lip mobility is 6 to
8 mm.7 A hypermobile lip can be treated using Botox.
d. Lower lip: the role of the lower lip in smile esthetics has not been analyzed as
comprehensively even though the lower lip creates the smile frame. The current
standard of beauty is a voluminous lower lip. Furthermore, the maxillary incisal
edge should touch the lower lip in a social smile; however, a 0.5 mm gap was
still considered esthetic.23 The smile index is defined as the intercommisural
width divided by the interlabial gap during a smile (Fig. 10).24 Generally, an
esthetic smile index is greater than 5.0 and less than 7.5.25 A spontaneous smile
with interocclusal space will generally have a greater smile index than a posed
smile. A smile index greater than 7.5 indicates the aging of a smile due to the
Fig. 8. A. Lip length. Measured from the base of the nose to the inferior border of the upper
lip.
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Smile Analysis 313
Fig. 9. Lip mobility. Length of blue line to red line 5 9 mm. Hypermobile. Lip resulting in
excessive gingival display.
greater width and the smaller interlabial gap. If the upper lip and maxillary
occlusal planes are in the ideal position, the reduced interlabial gap is due to
the higher position of the lower lip position, which could be due to the reduced
OVD.
3. Gingival esthetics: gingival architecture is fundamental to smile design. Color, stip-
pling, and biotype are essential components of pink esthetics.
a. Gingival design: as discussed by Fradeani, the gingival margin should maintain
parallelism with the occlusal plane and horizontal references such as the IPL
and CL (Fig. 11).9 Furthermore, the gingival margin should maintain the proper
curvature to match incisal edges and the smile arc. Soft tissue grafting and
crown lengthening are periodontal procedures used to achieve harmonious
gingival margins. The classic gingival design is where the canines and central
incisor gingival margin falls on the same line with the laterals slightly coronal
(1–2 mm).5 Variations exist such as the modified gingival designed where the
centrals and laterals are on the same line. The classic literature has focused
on the anterior 6; however, with the focus on wider smiles, the posterior teeth
gingival margins should be taken into consideration. Crawford and colleagues26
suggested the esthetic zone for posterior teeth, which is defined as a tangent
from the canine margin to the lower border of the upper lip superior to the first
molar. An acceptable range for the premolars is 2 mm apical to the line and
1 mm for molars. Further studies are needed to evaluate posterior teeth
Fig. 10. Smile index 5 intercommisural width/interlabial gap. The esthetic range is 5 to 7.5.
A greater smile index could be related to a smaller interlabial gap due to a collapsed OVD.
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Fig. 11. Ideal gingival design. (1) Canine sand centrals on a straight line; (2) laterals slightly
incisal to the line. Gingival margin follows smile arc. (From Levine JB, Finkel S. Smile Design
Integrating Esthetics and Function. Vol Volume Two. (Levine JB, ed.). ELSEVIER; 2016.)
esthetics as the demand for wider smiles increases. The gingival zenith is
defined as the most apical point of the gingival margin. Traditionally, the zenith
is located slightly distal to the midline of the centrals and in the center for laterals
and canines.27
b. Gingival exposure: Robbins and colleagues7 suggested that gingival display
more than 2 mm in a high smile is regarded as excessive. In the spontaneous
smile, Machado and colleagues5 suggested that 3 mm is the threshold for a
gummy smile. Therefore we suggest that gingival exposure of more than 2 to
3 mm is regarded as excessive (Fig. 12). Treatment of a gummy smile depends
on the Global Diagnosis system discussed later in this article.
c. Papillary height: Hochman and colleagues28 reported that the length of the
papilla was 40% the length of the tooth from the zenith to the incisal edge.
Furthermore, they reported that 87% of patients with low smiles displayed
papilla. Therefore, when designing smiles of patients with low smiles, it is crucial
to maintain the papillary display.28 Long contacts with no papilla are regarded as
unesthetic and should be avoided. Tooth and restoration shapes play an impor-
tant role in papilla height. Triangular and oval-shaped restorations have shorter
contacts and longer papilla. If the height from the base of the contact to the
crest of the bone is more than 5 mm then a longer contact or more square resto-
ration is necessary to avoid the formation of a black triangle.29
4. Dental esthetics: in this section, the authors discuss different specifics of white es-
thetics that need to be taken into consideration during smile design.
a. Incisal edge position: this is the most important factor in determining tooth po-
sition in smile design. Maxillary central incisal edge is determined in repose and
full smile. In repose, if lip length is normal, the incisal edge display is 3 to 4 mm in
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Smile Analysis 315
women and 1 to 2 mm in men (Fig. 13).30 More incisal display indicates a more
youthful and attractive smile. In full smile, Gaikwad and colleagues reported that
the best esthetic result is when the maxillary centrals contacted the lower lip
even though 0.5 mm distance between the incisal edge and the lower lip was
still considered esthetic.23,31 Moreover, Pound reported that in an E-Smile
(spontaneous) the maxillary centrals should occupy between 50% and 80%
of the interlabial distance.32 The F sounds are also used to determine the incisal
edge position. During gentle pronunciation of the F sounds, the incisal edge
should touch the wet/dry border of the lower lip.16
b. Smile Arc: smile arc refers to the position of the maxillary incisors in a vertical
position. Profitt and colleagues33 reported that the smile arc is the most impor-
tant factor of the smile. Smile arc is classified into 3 categories: convex/positive,
straight/plane, or inverted/reverse (Fig. 14). The positive smile is the most
esthetic and is defined as when the maxillary incisal edges cradle the lower
lip. Al Johany and colleagues34 found that positive smiles were seen in 78%
of celebrity smiles. In a positive smile, the incisal edge of the maxillary central
is more incisal than the canines. Furthermore, there is a 0.5 to 1 mm step be-
tween the incisal edge of the maxillary centrals and the laterals in men and
1.0 to 1.5 mm step in women.5 This ensures the dominance of the maxillary cen-
trals. To create a less dominant smile, the clinician can decrease the maxillary-
lateral incisal edge step and position the maxillary central incisal edge at the
same level as the canine edge.
c. Maxillary central dimensions and symmetry: once the vertical position of the
maxillary centrals is established, the length and the width need to be deter-
mined. The range for width:height ratio of the maxillary centrals is 75% to
85%.35 Slender teeth are more common in women, whereas male teeth are
closer to 85%. Any ratio greater than 85% is regarded as unesthetic. The
esthetic guide for hard tissue developed by Chu and colleagues36 uses mathe-
matical formulas to calculate the width and height of maxillary and mandibular
anteriors as well as intratooth relationships. If the width of the central is X, the
lateral is X-2, whereas the canine is X-1. The height can then be calculated by
dividing by 0.78 (dentist preferred W/H ratio) (Fig. 15). Based on this formula:
the width of the mandibular central 5 X-3 and the average dimensions of the
centrals are 8.5 mm wide and 11 mm long. Gender and face size play a major
role in teeth dimensions.36 Natural smiles have a degree of asymmetry;
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316 Sabbah
however, symmetry was found to be most crucial for the maxillary central inci-
sors. Asymmetry was less noticeable further from the midline.37
d. Proportions between anterosuperior teeth: the intertooth relationship between
the maxillary anteriors has been studied extensively through the years. Levin
proposed the golden ratio in 1978, which suggested that in the facial view the
width of the laterals is 62% the width of the centrals and that the width of the
canines is 62% the width of the laterals.38 The golden proportion was found
to not exist in nature and was regarded as unesthetic in several studies due
to the narrowing of the smile.39 With the emphasis on wider smiles in modern
smile design, other proportions are regarded as more esthetic. The recurring
esthetic dental (RED) proportion has been proposed by Ward and colleagues40
as a model for modern smile design. RED proportion ranges from 62% to 80%
and differs based on the desired length of teeth and height and gender of the
patient. For shorter teeth, the 80% RED proportion was found to be the most
esthetic, whereas for longer teeth the 62% RED (Golden) was ideal (Fig. 16).
e. Presence of diastemas: in general, all anterior diastemas should be closed un-
less requested by the patient. An untreated maxillary median diastema (MMD) of
more than 0.5 mm was regarded as less esthetic41 Moreover, MMD of more
than 4 mm is recommended to be restored by an interdisciplinary approach
of orthodontics and restorations.41 In these cases the use of restorative alone
results in abnormal tooth shape that does not follow the W/H ratio of 78%.
Recently, Bioclear has been marketed as a solution for diastema closures. It
is the authors’ opinion that Bioclear results in W/H ratio greater than 78%, which
produces an unesthetic smile with square teeth, long contacts, and papillary
height less than 40%.
f. Buccal corridors: this is defined as the dark space between the buccal of the
maxillary teeth and the labial commissure during smiling. Buccal corridors
can be classified as narrow, intermediate, or wide.5 The effect of the buccal
corridor on smile esthetics has been controversial, with some studies reporting
that laypeople did not notice a difference, whereas other studies reported that
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Smile Analysis 317
Fig. 15. Intratooth dimensions as proposed by Chu. (From German DS, Chu SJ, Furlong ML,
Patel A. Simplifying optimal tooth-size calculations and communications between practi-
tioners. Am J Orthod Dentofac. 2016;150(6):1051-1055. https://doi.org/10.1016/j.ajodo.
2016.04.031.)
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318 Sabbah
Fig. 16. Different RED proportions for anterior teeth ratios. (From Ward DH. Proportional
Smile Design. Dent Clin N Am. 2015;59(3):623-638. https://doi.org/10.1016/j.cden.2015.03.
006.)
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Smile Analysis 319
Fig. 17. Facial flow: the green side is the side that the dental midline can “flow” toward. A
midline shift toward the red side is more noticeable.
Fig. 18. Teeth anatomy fundamentals in modern smile design. (From Levine JB, Finkel S.
Smile Design Integrating Esthetics and Function. Vol Volume Two. (Levine JB, ed.). ELSEVIER;
2016.)
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320 Sabbah
1. Line angles: these give the general outline of the teeth and control the
width. Altering the line angles can make a tooth look wider or narrower.
2. Height of contour: located distal to the midline in the gingival third. Anterior
maxillary teeth have 3 planes.
3. Contacts: contact areas start at 40% at the midline and decrease distally.
Contact points move more apically as in a distal direction.
4. Incisal embrasures: incisal embrasures increase gradually as we move
distally starting at 20% of the tooth height at the midline to 35% at the
distal of the canines.
5. Incisal edge: incisal edge anatomy and translucency are essential in
creating a more natural smile. Younger patients have more defined incisal
edges with mamelons. The opalescence that is seen at the incisal edge
must be created in restorations to avoid the artificial look.
6. Texture: microtexture: these are developmental grooves that are found in
younger teeth and usually run horizontally. Macrotexture refers to lobes that
divide the facial surface of teeth into distinct concavities and convexities.9
7. Tooth shape: different concepts have been proposed to aid in the selec-
tion of tooth shapes and forms. Leon Williams proposed that the shape of
the maxillary anteriors should match the face form. The 3 proposed
shapes were square, triangular, and ovoid.47 Contemporary teeth selec-
tion has focused on incorporating a patient’s personal identity and facial
features to create a more personalized smile.18 Gurel and colleagues
created the VIS, which developed an association between esthetics, func-
tion, artistic visual language, facial recognition, and personality typology
to develop 4 smile design types outlined as follows:
a. Strong: composed of mainly rectangular shapes, strong dominance
b. Dynamic: triangular shapes, standard dominance
c. Delicate: oval shapes, medium dominance.
d. Calm or stable: smoothly rounded square with weak dominance
8. Teeth library: historically, the anatomy of restorations depended on the
laboratory technician fabricating the case and their comfort level. Digital
dentistry has opened the possibility for infinite libraries, shapes, and
molds of teeth. In addition, patients can select and visualize a tooth library
before fabrication; this is one of the main principles of DSD. In addition,
digital dentistry allows us to “copy” natural libraries from one patient
and “paste” them into another. This copy-paste concept was developed
by Dr Christian Coahcman and emphasizes the use of natural teeth library
to create a natural-looking smile, rather than using artificial libraries.
Clinical tip: all the following lead to aging of the smile and should be avoided during
smile design18:
Flattened incisal edges
Smaller incisal embrasures
Smoother facial texture
Prominent mandibular display
Increase chroma
Anterior splaying
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Smile Analysis 321
esthetics without an understanding of airway, function, structure, and biology will al-
ways fail in treating most smile design cases. Patients who report for smile makeovers
usually have complicated cause that has resulted in the unesthetic outcome pre-
sented. Therefore, the modern smile design team should consist of general practi-
tioners and specialists with interdisciplinary knowledge.
Several interdisciplinary treatment planning concepts have been developed over
the years. Dr Roblee proposed the interdisciplinary dentofacial therapy (IDT) model.48
Dr Roblee defines IDT as a synergist relationship “between” specialties rather than
each specialty acting independently (multidisciplinary). The IDT model has evolved
to the more contemporary model called mature IDT. Mature IDT focuses on an
evidence-based approach with common goals and cloud-based communication.
Communication had been the biggest challenge when dealing with these cases.
The development of DSD and asynchronous communication by Dr Christian
Coachman has revolutionized the treatment of these interdisciplinary cases.49
Another interdisciplinary treatment planning concept is the facially generated treat-
ment planning (FGTP) approach proposed by Dr Frank Spear and Dr John Kois.50
Traditional treatment planning focused on collecting data and findings through a
comprehensive diagnostic approach with casts, radiographs, and a clinical examina-
tion to develop a treatment plan; this is an “inside-out” approach, starting with the
biology, structure, function, and then esthetics of the teeth. As a result, the esthetic
result was frequently compromised, as the end result could not be visualized ahead
of time. Think about trying to put pieces of a puzzle together without knowing what
the outcome should look like. Furthermore, the esthetic result relied primarily on the
orodental complex without much attention to the face.
The Great Pyramids of Giza are some of the wonders of the world that took 30 years
each to build. Imagine the ancient Egyptians inspecting the structure of each block
and stacking them one by one without having an end goal. Thirty years later they
decide they did not like the final result. That is how inside-out treatment planning
works (Fig. 19). The ancient Egyptians used an “outside-in” approach, where they
visualized an end result, then reverse-engineer the construction. Frank Spear and
John Kois were the first to adopt this “outside-in” approach to treatment planning.50
The logic stemmed from the popular saying by Dr Peter Dawson: “If you know where
are and know where you want to go, getting there is easy.”16 In essence, you need to
know what the puzzle looks like before putting the pieces together. FGTP starts with
the end in mind with emphasis on facial and dental Esthetics followed by Function,
Structure, and Biology (EFSB system).51 More recently, Airway has been added to
the equation, where airway has become the first step in FGTP (AEFSB system)
(Fig. 20). Instead of expanding the smile with veneers and camouflaging a constricted
maxilla, expanding the airway with orthodontics would result in ideal esthetics while
addressing airway issues resulting in a healthier outcome.52 Linking esthetics to health
emphasizes the newly discovered importance of ideal smile design in achieving overall
health.
Airway phase: this starts with the examination of the airway before deciding on
the position of the teeth. The first step is a sleep questionnaire such as the Ep-
worth Sleeping Scale (ESS), Berlin, or the Wisconsin sleep questionnaire.53 A
proper examination is needed that includes body mass index, craniofacial
morphology, tongue, and pharyngeal size, palatine tonsils, and teeth wear pat-
terns. Once airway involvement is suspected, several screening tools are
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322 Sabbah
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Smile Analysis 323
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GLOBAL DIAGNOSIS
In 2016 Robbins and Rouse established a model to address gingival display7. They
concluded that even though the incisal edge position generated by FGTP was ideal,
the final result may be unsatisfactory in some cases due to excessive gingival display.
They developed the Global Diagnosis approach that focuses on the “gummy smile.”7
The 4, 5, 6 concept states that there are (4) global diagnoses for interdisciplinary treat-
ment planning, (5) core questions to determine the diagnosis, and (6) treatment op-
tions (Fig. 21).
The 4 global diagnoses:
1. Upper lip: short/long or hypermobile/hypomobile
2. Clinical crowns:
- Short: microdontia, incisal wear or altered passive eruption
- Long: recession
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Smile Analysis 325
7. Altered passive eruption: the patient has short teeth, CEJ cannot be detected in the
sulcus, and usually there is no wear on the incisal edge (Fig. 24).
8. Recession: the patient’s teeth are long, and the CEJ is visible
The 6 treatment options:
1. Orthognathic surgery:
Global Diagnosis: VME
- Primary treatment: maxillary Le Fort I impaction
2. Plastic surgery:
Global Diagnosis: short upper lip
- Primary treatment: Botox and lip fillers
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3. Orthodontics:
Global Diagnosis: dentoalveolar extrusion
- Primary treatment: orthodontic intrusion, restorative dentistry
4. Restorations
Global Diagnosis: microdontia.
- Primary treatment: restorative such as veneers, crowns, or composites
5. Crown lengthening:
Global Diagnosis: altered passive eruption
- Primary treatment: esthetic crown lengthening is completed from facial
Fig. 23. U-shaped gingiva and bone in dentoalveolar extrusion of maxillary anterior teeth.
Treatment is functional crown lengthening.
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Smile Analysis 327
Fig. 24. Altered passive eruption treated with esthetic crown lengthening.
It is important to note that alternative treatment plans can be proposed if the patient
does not want to proceed with the “ideal” plan, especially in the case of orthognathic
surgery. Even though a La-Forte 1 might be indicated, an alternative plan such as crown
lengthening, Botox, and restorative might be enough to address the patient’s esthetic
concern; this is the power of digital planning, where the patient can visualize the end
result of several plans and mock-ups and go with an informed decision. As with all treat-
ment plans, the pros and cons need to be discussed with the patient. Care should be
taken not to compromise the final result when selecting an alternative plan.
Rationale: the 2 treatment planning concepts outlined earlier provide the practitioner
with very powerful tools to guide planning advanced interdisciplinary cases. It is the
authors’ opinion that these 2 concepts can be merged into a more inclusive compre-
hensive treatment plan philosophy focused on the concepts of Digital Smile Design
with Global Diagnosis and FGTP. This proposed concept is termed Smile Design
Treatment Planning (SDTP) and provides the practitioner with a treatment sequence
when dealing with smile design cases. Once the ideal smile is designed, the clinician
uses the decision trees discussed later to decide treatment options. Because of the
novelty of this concept, changes will be made in the future to address emerging
concepts.
Nine steps for SDTP:
1. Data acquisition phase
2. Airway analysis
3. Facial analysis
4. OVD and TMJ analysis
5. Lip analysis
6. Dental analysis
7. Gingival analysis
8. Mandibular arch and occlusal analysis
9. Virtual treatment analysis
Step 1: data acquisition phase:
Phase summary: during this phase, the clinician collects diagnostic data for
case analysis. These data are used to construct a virtual patient for digital
treatment planning. An SDTP checklist is also used to provide clinical data
(Fig. 25).
Requirements:
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328 Sabbah
- 5 DSD photos: frontal smile with teeth apart, frontal retracted with teeth
apart, profile at rest, profile at smile, and 12 o’clock smile view54
- Repose picture at physiologic rest position (PRP)
- Video of the patient in repose, full smile, spontaneous smile, phonetics
- Kois Dento-Facial Analyzer or digital facebow.
- STLs at current OVD and proposed OVD
- SDTP checklist.
Optional data: facial scan, cone beam computed tomography (for implant planning,
guided crown lengthening), cephalometric (orthognathic, orthodontics, and airway
analysis), Viewing/Design Software—DSD, Smilefy, Exocad, 3Shape Trios, BlueSky-
Bio (Free), MeshMixer (Free)—or other applicable alternatives.
Step 2: airway analysis
Phase summary: during this phase, the dentist screens the patient for possible
airway involvement. This involves an extraoral and intraoral clinical examina-
tion, sleep questionnaire, and possible use of HRPO if airway issues are sus-
pected (discussed earlier). OVD is also assessed at this phase and whether the
airway would benefit from increasing the OVD. Airway analysis is also inte-
grated into some of the following steps. Possible airway changes must be
considered in each step of SDTP.
Step 3: facial analysis (Fig. 26)
Phase summary: during this phase, the face is analyzed in repose at PRP in
profile and frontal view. Global diagnosis rules are followed.
- In the frontal view: if the middle:lower face is 1:1 then face proportions are
normal. If the lower third is longer then the diagnosis is VME, and the primary
treatment is La-Forte 1 impaction. If the middle face is longer then the diag-
nosis is VMD, and the primary treatment is maxillary downfracture, BSSO.7
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Smile Analysis 329
-The facial flow is also analyzed in this view and decided whether it is perpen-
dicular or curved.
- In profile, Rickett’s line is used as a reference. If the lower lip is greater than
2 mm posterior, then the face is convex, and the patient is class II. The
dentist should be aware of possible airway issues in class II patients due
to decreased airway volume.55 In addition, if the OVD is increased, care
should be taken whether to restore the patient in centric relation (CR) or
centric occlusion (CO). Restoring a class I or class II patient in CR could
worsen airway issues by decreasing airway volume due to the posterior
reposition of the mandible. An airway analysis should be conducted with
provisional restorations or splint at an open OVD if CR will be used to
examine airway volume.56 If the lower lip is less than 2 mm posterior to
the line, then the face is concave (class III), and orthodontics and orthog-
nathic surgery should be considered. Opening the OVD could improve the
overbite/overjet relationship for these patients. In some class III patients,
the maxilla is deficient and airway volume is decreased.57
Step 4: OVD and TMJ analysis (Fig. 27)
Phase summary: once facial and airway analysis is complete, the clinician can
now assess the patient’s OVD. There are several methods to determine the
PRR and OVD.58 Facial esthetics can be used as a guide to determine the
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330 Sabbah
Fig. 27. OVD and TMJ analysis in SDTP and treatment options.
short lip is to be treated with Botox, whereas a long lip can be treated with a
lip lift procedure.
- Lip mobility: normal mobility is 6 to 8 mm. A hypermobile lip is treated with
Botox, whereas a hypomobile lip can be treated with Botox and smile
exercises.
- Lip volume: thin lips are treated with lip fillers.
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Smile Analysis 331
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332 Sabbah
Fig. 29. Incisal edge position analysis, facial analysis phase of SDTP.
Size of maxillary centrals: the average size is 10 to 11 mm. Short teeth indicate
microdontia or incisal wear and are treated restoratively. Longer teeth with
exposed CEJ are treated restoratively or with soft tissue grafting (Fig. 30).
Dental midline position: once the centrals are set, the dental midline is
analyzed in reference to the facial flow. Up to 2 mm deviation is considered
esthetic. If the flow is straight, the midline should be parallel. In cases where
the flow is curved, the midline angulation should flow in the same direction
as the flow toward the green side. Deviations can be treated with orthodontics
or restorative (see Fig. 30).
Occlusal plane: the horizontal plane should be set parallel to the IPL. In cases
where the IPL and ICL are not parallel, the ICL is recommended. The trans-
verse plane is set parallel to Camper’s line. Variations are treated with ortho-
dontics, orthognathic, or restorative (see Fig. 30).
Smile arc: straight or convex smile arcs are recommended. If a more dominant
smile is desired, the incisal step between the laterals and the centrals is made
to be steeper. The smile arc should follow the lower lip. In the case of a
concave smile arc, the treatment options are extrusion of the incisors with or-
thodontics or restorative dentistry to make the teeth longer. The clinician must
consider how this would affect OVD, overjet, overbite, incisal edge display in
repose, and envelop of function as discussed later (see Fig. 30).
Size of anterior teeth: once the size of the maxillary centrals is established, the
RED proportions and Chu guidelines are used to decide on the size of the re-
maining anterior teeth. The RED proportions vary between 62% and 80% de-
pending on the gender and size of the patient. If the teeth are wider than
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Smile Analysis 333
Facial flow
Short Normal Long
<10-11 mm 10-11 mm >10-11 mm
• Incisal wear • Macrodontia
• Microdontia • Recession Straight Curved
• APE (-CEJ) • Tall patient
Normal Normal
• <2 mm deviation • <2 mm deviation
• Parallel to facial • Towards green
• Restorative • Restorative midline side
• Esthetic crown pink porcelain
lengthening • Pink porcelain Abnormal Abnormal
• Soft tissue >2 mm deviation >2 mm deviation
grafting canted towards red side
• Orthodontics
• Restorative
Normal Normal
• Orthodontics • Parallel to IPL and ICL • Parallel to Camper’s
• Restorative • If IPL and ICL are not line
paralle: Follow ICL
Deviations
• Orthodontics
• Restorative
Fig. 30. Size of maxillary centrals, position of dental midline, occlusal plane orientation,
smile arc position. Facial analysis phase of SDTP.
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334 Sabbah
• Bleaching protocols
• Restorative
Fig. 31. Size of anterior teeth, tooth anatomy, tooth color, facial analysis phase of SDTP.
diagnosis is DAE, and the treatment options are orthodontic intrusion or func-
tional crown lengthening and restorative. Gingival exposure in full smile should
be 2 to 3 mm. Excessive gingival exposure can be due to hypermobile lip, short
lip, VME, or APE if CEJ is not detectable. If gingival exposure is deficient, rea-
sons could be long lip, hypomobile lip, VMD, or recession. Treatment options
for these have been described earlier. Papillary height ideally is 40%. If it is
more than 40%, crown lengthening and changing the shape of the teeth can
be done if desired. If papilla height is less than 40% and black triangles are pre-
sent: longer contacts are recommended. If black triangles are absent, then
changing the shape of the teeth and soft tissue grafting may lead to an in-
crease in height of the papilla.
Step 8: mandibular arch and occlusion analysis
Phase summary: once the maxillary arch is set, the mandibular arch and occlu-
sion are established.
- Mandibular incisal edge is decided at the proposed vertical from step 4. If the
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Smile Analysis 335
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336 Sabbah
patients with mandibular wear (Fig. 34). The treatment of choice is functional
crown lengthening and restorative or orthodontic intrusion and restorative.
Step 9: virtual treatment phase (Fig. 35)
Phase summary: once the virtual plan is established, the patient is presented
with 2 plans. The 2-dimensional plan is based on a photographic mock-up using
traditional applications such as PowerPoint or contemporary digital technology
such as DSD, SmileFy, or Exocad. During this phase, the clinician involves the
patient in step-by-step plan such as selection of teeth library, shape, sizes
incisal edge display, gingival design, and other variables. The more powerful
part of the virtual treatment is based on the 3-dimensional design with the
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Smile Analysis 337
Fig. 34. Dentoalveolar extrusion of the mandibular anteriors. Patient treated with func-
tional crown lengthening of lower anteriors and crowns.
Virtual patient
2D plan 3D plan
• Power point • DSD
• DSD • Exocad
• Exocad • Smilefy
• Smilefy • Zirkonzahn
• Trios 3 shape
• Meshmixer (free)
• Blueskybio (free)
• Others
Additive Subtractive
• Motivational mock up
• Plan exection
• Emotionl presentation
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338 Sabbah
when the actual treatment starts; this is not additive and is more anatomic. This
step is explained in more detail when discussing DSD.62
SUMMARY
ACKNOWLEDGEMENT
The author wishes to acknowledge: Dr. Nasser Barghi for his contributions to clinical
photos, his mentorship and guidance over the years, Dr. Nazgol Zamanian and Dr.
Alireza Karimi for their input in manuscript preparation, former AEGD resident Dr. Lau-
ren Berischwale and former dental student Dr. Kristi Morris for their contribution to
clinical photos, Dr. Rebeca Garcia and Dr. Kristen Reitano for their contribution to clin-
ical cases presented in this chapter.
REFERENCES
1. Darwin C. In: Murray J, Street A, editors. The expression of the emotions in man
and animals. 1872. Available at: https://pure.mpg.de/rest/items/item_2309885/
component/file_2309884/content. Accessed February 8, 2022.
2. Harker L, Keltner D. Expressions of positive emotion in women’s college yearbook
pictures and their relationship to personality and life outcomes across adulthood.
J Pers Soc Psychol 2001;80(1):112–24.
Descargado para Lucia Angulo ([email protected]) en National Library of Health and Social
Security de ClinicalKey.es por Elsevier en julio 20, 2022. Para uso personal exclusivamente. No se
permiten otros usos sin autorización. Copyright ©2022. Elsevier Inc. Todos los derechos reservados.
Smile Analysis 339
3. Beall AE. Can a new smile make you look more intelligent and successful? Dent
Clin North Am 2007;51(2):289–97.
4. Davis NC. Smile Design. Dent Clin N Am 2007;51(2):299–318.
5. Machado AW. 10 commandments of smile esthetics. Dent Press J Orthod 2014;
19(4):136–57.
6. Mahn E, Sampaio CS, Silva BP da, et al. Comparing the use of static versus dy-
namic images to evaluate a smile. J Prosthet Dent 2020;123(5):739–46.
7. Robbins JW, Rouse JS. Global diagnosis A new vision of dental diagnosis and
treatment planning, 4. Quintessence; 2016. https://doi.org/10.25241/stomaeduj.
2017.4(3).bookreview.2.
8. Meiyappan N, Tamizharasi S, Senthilkumar KP, et al. Natural head position: An
overview. J Pharm Bioallied Sci 2015;7(Suppl 2):S424–7.
9. Fradeani M. Esthetic rehabilitation in fixed prosthodontics, 1. Quintessence Pub-
lishing Co Inc; 2004. Available at: http://www.quintpub.com/display_detail.php3?
psku5BI004#. Accessed February 13, 2022.
10. Arroyo-Cruz G, Orozco-Varo A, Vilches-Ahumada M, et al. Comparative analysis
of smile aesthetics between top celebrity smile and a Southern European popu-
lation. J Prosthet Dent 2021. https://doi.org/10.1016/j.prosdent.2021.03.019.
11. Silva BP, Jiménez-Castellanos E, Finkel S, et al. Layperson’s preference
regarding orientation of the transverse occlusal plane and commissure line
from the frontal perspective. J Prosthet Dent 2017;117(4):513–6.
12. Silva BP, Mahn E, Stanley K, et al. The facial flow concept: an organic orofacial
analysis—the vertical component. J Prosthet Dent 2018;121(2):189–94.
13. The glossary of prosthodontic terms ninth edition. J Prosthet Dent 2017;117(5):
e1–105.
14. Priest G, Wilson MG. An evaluation of benchmarks for esthetic orientation of the
occlusal plane. J Prosthodont 2017;26(3):216–23.
15. Mazurkiewicz P, Oblizajek M, Rzeszowska J, et al. Determining the occlusal
plane: a literature review. Cranio 2019;1–7. https://doi.org/10.1080/08869634.
2019.1703093.
16. Levine JB, Finkel S. Smile design integrating esthetics and function. vol. 2. Levine
JB, editor. ELSEVIER; 2016;1:1–42.
17. Farias F de O, Ennes JP, Zorzatto JR. Aesthetic value of the relationship between
the shapes of the face and permanent upper central incisor. Int J Dent 2010;
2010:561957.
18. Gurel G, Paolucci B, Lliev G, et al. The art and creation of a personalized smile:
visual identity of the smile. Quintessence: VIS; 2019.
19. Sforza C, Laino A, D’Alessio R, et al. Soft-tissue facial characteristics of attractive
italian women as compared to normal women. Angle Orthod 2009;79(1):17–23.
20. Stanley K, Caligiuri M, Schlichting LH, et al. Lip lifting: unveiling dental beauty. Int
J Esthetic Dent 2017;12(1):108–14.
21. Fink B, Neave N, Seydel H. Male facial appearance signals physical strength to
women. Am J Hum Biol 2007;19(1):82–7.
22. Roe P, Rungcharassaeng K, Kan JYK, et al. The influence of upper lip length and
lip mobility on maxillary incisal exposure. Am J Esthetic Dentistry 2012.
23. Tosun H, Kaya B. Effect of maxillary incisors, lower lip, and gingival display rela-
tionship on smile attractiveness. Am J Orthod Dentofac 2020;157(3):340–7.
24. Sarver DM, Ackerman MB. Dynamic smile visualization and quantification: part 2.
smile analysis and treatment strategies. Am J Orthod Dentofac 2003;124(2):
116–27.
Descargado para Lucia Angulo ([email protected]) en National Library of Health and Social
Security de ClinicalKey.es por Elsevier en julio 20, 2022. Para uso personal exclusivamente. No se
permiten otros usos sin autorización. Copyright ©2022. Elsevier Inc. Todos los derechos reservados.
340 Sabbah
Descargado para Lucia Angulo ([email protected]) en National Library of Health and Social
Security de ClinicalKey.es por Elsevier en julio 20, 2022. Para uso personal exclusivamente. No se
permiten otros usos sin autorización. Copyright ©2022. Elsevier Inc. Todos los derechos reservados.
Smile Analysis 341
46. Murro BD, Gallusi G, Nardi R, et al. The relationship of tooth shade and skin tone and
its influence on the smile attractiveness. J Esthet Restor Dent 2020;32(1):57–63.
47. Kumar MV, Ahila SC, Devi SS. The science of anterior teeth selection for a
completely edentulous patient: a literature review. J Indian Prosthodont Soc
2011;11(1):7–13.
48. Roblee RD. Interdisciplinary dentofacial therapy (IDT): a comprehensive approach
to optimal patient care. Quintessence: Quintessence Publishing Co Inc; 1994.
49. Blatz MB, Chiche G, Bahat O, et al. Evolution of aesthetic dentistry. J Dent Res
2019;98(12):1294–304.
50. Spear Kokich FM, Mathews VG. Interdisciplinary management of anterior dental
estheticsSpear. JADA 2006.
51. Sabbah A. An introduction to contemporary treatment planning.pdf. Metlife, ed.
2021. Available at: https://metdental.ecepartners.com/coursereview.aspx?
url51902%2FHTML%2FAn_Introduction_to_Contemporary_Treatment_Planning
%2Findex.html&scid515011. Accessed February 20, 2022.
52. Rouse J. Airway and 3D treatment planning - spear education. 2019. https://www.
speareducation.com/spear-review/2019/11/airway-and-3d-treatment-planning.
Accessed February 10, 2022.
53. Masoud AI, Jackson GW, Carley DW. Sleep and airway assessment: a review for
dentists. Cranio 2016;35(4):206–22.
54. Yoshinga C. Yoshinga. DSD photo and video protocol. Available at: https://www.
dsdplanningcenter.com/pdf/dsd-video-photo-protocol.pdf. Accessed February
20, 2022.
55. Kirjavainen M, Kirjavainen T. Upper airway dimensions in class II malocclusion.
Angle Orthod 2007;77(6):1046–53.
56. Harrell WE, Tatum T, Koslin M. Is centric relation always the position of choice for
TMDs? case report of how TMD and airway dimension may be associated. Com-
pendium 2017. Available at: https://www.aegisdentalnetwork.com/cced/2017/04/
is-centric-relation-always-the-position-of-choice-for-tmds-case-report-of-how-
tmd-and-airway-dimension-may-be-associated. Accessed February 20, 2022.
57. Chen X, Liu D, Liu J, et al. Three-dimensional evaluation of the upper airway
morphological changes in growing patients with skeletal class III malocclusion
treated by protraction headgear and rapid palatal expansion: a comparative
research. PLoS One 2015;10(8):e0135273.
58. Calamita M, Coachman C, Sesma N, et al. Occlusal vertical dimension: treatment
planning decisions and management considerations. Int J Esthetic Dent 2019;
14(2):166–81.
59. Goldstein G, Goodacre C, MacGregor K. Occlusal vertical dimension: best evi-
dence consensus statement. J Prosthodont 2021;30(S1):12–9.
60. Abduo J, Lyons K. Clinical considerations for increasing occlusal vertical dimen-
sion: a review. Aust Dent J 2012;57(1):2–10.
61. Miralles R. Canine-guide occlusion and group function occlusion are equally
acceptable when restoring the dentition. J Évid Based Dent Pract 2016;
16(1):41–3.
62. Coachman C, Georg R, Bohner L, et al. Chairside 3D digital design and trial
restoration workflow. J Prosthet Dent 2020;124(5):514–20.
Descargado para Lucia Angulo ([email protected]) en National Library of Health and Social
Security de ClinicalKey.es por Elsevier en julio 20, 2022. Para uso personal exclusivamente. No se
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