Table 17-3
Table 17-3
Table 17-3
Epilepsies
Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann+
Table 17–3Interactions of Anti-Seizure Drugs with Hepatic Microsomal Enzymes
Brivaracatam No No No No 2C19/2C9 No
Clobazam No No No No 3A4 No
Clonazepam No No No No 3A4 No
Ethosuximide No No No No 3A4 No
Ezogabine No No No No No Yes
Gabapentin No No No No No No
Lacosamide No No No No 2C19 ?
Lamotrigine No No No No No UGT1A4
Levetiracetam No No No No No No
Pregabalin No No No No No No
Stiripentol No No 1A2/3A4/2C19/2D6 No No No
Tiagabine No No No No 3A4 No
Vigabatrin No No No No No No
Zonisamide No No No No 3A4 No
CYP, cytochrome P450; UGT, uridine diphosphate-glucuronosyltransferase. (Data modified from Johannessen and Johannessen, 2010 and Wheles and Vasquez, 2010, Epilepsy Currents, 10:1–6 and Cawello,
2015, Clin Pharmacokinetic, 54: 904–914.)
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