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  • Linkage - S

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    Gideon Cavida
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    This document discusses linkage and recombination in genetics. It defines linkage as genes being located close together on the same chromosome, so they tend to be inherited together. It explains Morgan's discovery that the closer genes are, the more likely they are to be inherited together. It describes coupling and repulsion phenomena in linked genes and how crossover events can lead to incomplete linkage. It also discusses sex determination and X-linked inheritance patterns for traits like color blindness and hemophilia in humans. It provides example problems involving deducing the father's genotype based on a color-blind daughter and calculating inheritance probabilities for hemophilia in offspring.

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    Sex-linked mutation

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    linkage - s

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    This document discusses linkage and recombination in genetics. It defines linkage as genes being located close together on the same chromosome, so they tend to be inherited together. It explains Morgan's discovery that the closer genes are, the more likely they are to be inherited together. It describes coupling and repulsion phenomena in linked genes and how crossover events can lead to incomplete linkage. It also discusses sex determination and X-linked inheritance patterns for traits like color blindness and hemophilia in humans. It provides example problems involving deducing the father's genotype based on a color-blind daughter and calculating inheritance probabilities for hemophilia in offspring.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    6 views14 pages

    Linkage - S

    Uploaded by

    Gideon Cavida
    This document discusses linkage and recombination in genetics. It defines linkage as genes being located close together on the same chromosome, so they tend to be inherited together. It explains Morgan's discovery that the closer genes are, the more likely they are to be inherited together. It describes coupling and repulsion phenomena in linked genes and how crossover events can lead to incomplete linkage. It also discusses sex determination and X-linked inheritance patterns for traits like color blindness and hemophilia in humans. It provides example problems involving deducing the father's genotype based on a color-blind daughter and calculating inheritance probabilities for hemophilia in offspring.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 14

    Linkage and Recombination

    Review of Mendelian genetics


     Dihybrid ratio:
    RrPp x RrPp
     Linkage:
    9 R_P_ (round, w/ tendrils) RP RP
    3 R_pp (round, w/o tendrils) x
    3 rrP_ (wrinkled, w/ tendrils)
    rp rp
    1 rrpp (wrinkled, w/o tendrils) 106 R_P_ (round, w/ tendrils)
    1 R_pp (round, w/o tendrils)
    1 rrP_ (wrinkled, w/ tendrils)
    41 rrpp (wrinkled, w/o tendrils)

     Independent  Linkage
    assortment The genes are located in the
    The genes are same chromosome and
    located in different they are close (linked) w/
    chromosomes each other (can be
    separated by recombination)
     Thomas Hunt Morgan
    The closer the genes, the greater the probability that they
    would be inherited together.

    Linked genes : AB
    ab
    Independently assorting genes : AaBb
     Coupling and repulsion phenomenon are concerned with
    linkage.

     Coupling -dominant alleles are on the same homologue


    chromosome and both recessive alleles are on the other
    homologue chromosome. Thus, the parental gametes are AB
    and ab. Some authors call this cis.

     Repulsion -each homologous chromosome has one dominant


    and one recessive allele from the two genes. Thus, the
    parental gametes are Ab and Ab. Some authors call this trans.
    Incomplete Linkage
    Crossing over:
    Single crossing over (SCO)
    Double crossing-over (DCO)
    Sex Determination
    Chromosomal sex determination
    Sex Linkage

    X-linked inheritance
    1. color-blindness in humans
    2. Hemophilia in humans
    Color Blindness

    Female Genotypes Phenotypes


    XCXC normal color vision
    XCXc normal color vision
    XcXc color blind
    Male Genotypes
    XCY normal color vision
    color blind
    XcY
    Problem 1
     Both the husband and wife have normal vision. A
    woman has a color-blind daughter. What can you
    deduce about the child’s father?
    Hemophilia

    Key: XH –normal
    Xh –hemophiliac

    P1: XHXh x XHY


    (Queen Victoria) (Prince Albert)
    Problem 2
    A hemophiliac man marries a woman who has a normal vision, but a
    carrier of a gene for hemophilia.

    a. What is the probability of having a hemophiliac daughter?


    b. What is the probability of having a hemophiliac son?

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