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    Mutations Worksheet

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    Sarah Lowther
    The document discusses different types of genetic mutations including point mutations and frameshift mutations. It provides examples of each and asks questions about how different mutations would affect the coding of proteins. Specifically: 1. It analyzes a point mutation in sickle cell hemoglobin that changes a single base pair and leads to production of a different amino acid. 2. It defines point and frameshift mutations as two common types and asks how they are similar and different with an example of each. 3. A geneticist found a mutation that did not affect the coded protein, and it asks what the most likely mutation type is.

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    Mutations Worksheet

    Uploaded by

    Sarah Lowther
    385 views2 pages
    The document discusses different types of genetic mutations including point mutations and frameshift mutations. It provides examples of each and asks questions about how different mutations would affect the coding of proteins. Specifically: 1. It analyzes a point mutation in sickle cell hemoglobin that changes a single base pair and leads to production of a different amino acid. 2. It defines point and frameshift mutations as two common types and asks how they are similar and different with an example of each. 3. A geneticist found a mutation that did not affect the coded protein, and it asks what the most likely mutation type is.

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    The document discusses different types of genetic mutations including point mutations and frameshift mutations. It provides examples of each and asks questions about how different mutations would affect the coding of proteins. Specifically: 1. It analyzes a point mutation in sickle cell hemoglobin that changes a single base pair and leads to production of a different amino acid. 2. It defines point and frameshift mutations as two common types and asks how they are similar and different with an example of each. 3. A geneticist found a mutation that did not affect the coded protein, and it asks what the most likely mutation type is.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    385 views2 pages

    Mutations Worksheet

    Uploaded by

    Sarah Lowther
    The document discusses different types of genetic mutations including point mutations and frameshift mutations. It provides examples of each and asks questions about how different mutations would affect the coding of proteins. Specifically: 1. It analyzes a point mutation in sickle cell hemoglobin that changes a single base pair and leads to production of a different amino acid. 2. It defines point and frameshift mutations as two common types and asks how they are similar and different with an example of each. 3. A geneticist found a mutation that did not affect the coded protein, and it asks what the most likely mutation type is.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    Mutations worksheet TASK A 1.

    Below is the base sequence for the normal protein for normal haemoglobin and the base sequence for the sickle cell haemoglobin. Normal: GGG CTT CTT TTT Sickle: GGG CAT CTT TTT a. Transcribe and translate the normal and sickle cell DNA. b. Identify this as a point or frame shift mutation. Explain. c. If the base sequence read GGG CTT CTT AAA instead, would this result in sickle cell haemoglobin? Explain. 2. There are several types of genetic mutations. List two. What do they have in common? How are they different? Give an example of each. 3. A geneticist found that a particular mutation had no effect on the protein coded by a gene. What do you think is the most likely type of mutation in this gene? Why? 4. Name one amino acid that has more than one codon. Name an amino acid that has only one codon 5. Look at the following sequence: THE FAT CAT ATE THE RAT. Delete the first H and regroup the letters in groups of three- write out the new groups of three. Does the sentence still make sense? What type of mutation is this an example of? You have a DNA sequence that codes for a protein and is 105 nucleotides long. A frameshift mutation occurs at the 85th base- how many amino acids will be correct in this protein? 6. Given the following three mRNA sequences, 2 code for the same protein. Which two? 1. AGU UUA GCA ACG AGA UCA 2 UCG CUA GCG ACC AGU UCA 3 AGC CUC GCC ACU CGU AGU

    TASK B a. Original DNA Sequence: T A C A C C T T G G C G A C G A C T mRNA Sequence: Amino Acid Sequence: b. Mutated DNA Sequence 1: T A C A T C T T G G C G A C G A C T Whats the mRNA sequence? (Circle the change) What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this? c. Mutated DNA Sequence 2: T A C G A C C T T G G C G A C G A C T Whats the mRNA sequence? (Circle the change) What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this? d. Mutated DNA Sequence 3: T A C A C C T T A G C G A C G A C T Whats the mRNA sequence? (Circle the change) What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this? e. Mutated DNA Sequence 4: T A C A C C T T G G C G A C T A C T Whats the mRNA sequence? (Circle the change) What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this? f. Mutated DNA Sequence 5: T A C A C C T T G G G A C G A C T What will be the corresponding mRNA sequence? What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this?

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