Read More About MBT Sepsityper IVD Workflow 1682516329
Read More About MBT Sepsityper IVD Workflow 1682516329
IVD
When every
minute counts
Early identification and appropriate treatment
of blood stream infections and sepsis has
tremendous benefits for patient outcomes
and healthcare economy.
To address this topic, Bruker offers the
MBT Sepsityper solution, which is performed
in conjunction with the Bruker IVD MALDI
Biotyper system, saving precious time when
every minute counts.
The Sepsityper pathogen identification work-
flow reduces the turnaround time resulting
from traditional positive blood culture (PBC)
identification workflows by up to 48 hours.
Identification results can therefore be
reported significantly faster to ICU consul-
tants, compared to traditional methods.
Within an hour after the PBC alert, the ICU
consultant can be informed about a clear and
actionable pathogen identification result,
possibly leading to therapy optimization.
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Have your patient in focus
The Sepsityper solution helps identifying Implementing the Sepsityper workflow is not only resulting in saving
microorganisms from positive blood cultures valuable time, but also offers a higher identification success rate, lead-
considerably faster than the traditional work- ing to a better informed decision making when it comes to adjusting
flows based on short subculture. patient therapy.
Saving hours can make the difference when The Rapid Sepsityper workflow was compared to short subculturing
a patient is facing bacteraemia, sepsis and methods which represented the routine standard of three different
other conditions related to the presence of clinical microbiology laboratories. In this study, the Rapid workflow
microorganisms in the bloodstream. proved to be superior to the subculturing methods, while additionally
benefiting from a significantly shorter time-to-report. A higher rate of
correct identifications was observed, both in terms of total identifica-
tions as well as for each different microbial group.
100
Rapid Sepsityper Short subculture
90
80
Percentage of correct identifications
70
60
50
40
30
20
For more details on the data shown, have
a look at our Application Note: 10
0
Gram-neg Gram-pos Anaerobes Yeasts
Comparison of Rapid Sepsityper results with those of short subculture for gram-
negatives, gram-positives, anaerobes and yeasts (% of correct ID)
App-Note 1889554 Arthur B. Pranada et al., Journal of Medical Microbiology 2022, Vol. 71, Issue 8.
MBT Sepsityper® IVD Kit
https://doi.org/10.1099/jmm.0.001571
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Fast and easy workflow
2 min Microorganism identification from PBC does not only require special
sample preparation, but also a dedicated software providing adapted
data processing taking the complexity of a blood-derived sample into
account.
Add 1 mL of washing
buffer and mix Additionally, the software will provide a warning in case a mixed
culture is detected, with an indication of the detected species.
30 sec
1 min
4
Get even more out of your PBC sample
IVD
HT
IVD
Covering thousands of species
HT
5
Clinical impact of a fast workflow
The Sepsityper solution shortens the identification time after a positive blood culture alert by up to 48 hours,
by eliminating the time-consuming step of culturing the microorganisms followed by fast identification using
MALDI-TOF mass spectrometry.
In combination with antibiotic stewardship programs, this rapid identification allows a much faster
optimization of antibiotic therapy in patients with sepsis, compared to conventional workflows.
Early results, which physicians can act upon to manage bloodstream infections, enforce the fight
against resistance, and improve patient outcomes.
Morning Batching
Standard Positive
Blood Culture Result ID next Day
Workflow
››
am
am
am
am
10
12
11
9
* Stoneking LR, The Journal of Emergency Medicine, Vol. 44, No. 1, pp. 1–8, 2013
6
Overall impact
Earlier de-escalation and/or administration of targeted antimicrobial treatment helps improving the
patient outcome and supports antimicrobial stewardship
Improving patient outcome may reduce the length of hospital stays and associated costs
Clear identification results allow more efficient communication between microbiologists and treating physicians
Afternoon Batching
››
pm
pm
pm
pm
pm
1
5
Prof. Dr. Alexia Verroken
University Hospital Saint-Luc, Brussels, Belgium
››
“Reducing turn-around-times of positive blood cultures with
MALDI-TOF MS ID accelerated prescription of targeted
antimicrobial treatment thereby potentially improving the
patient’s clinical outcome.”
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Order information
MALDI Biotyper ® is a registered trademark of the Bruker group of companies. Online information
Sepsityper ® is a registered trademark of the Bruker group of companies, bruker.com/microbiology
in the EU, Australia, China, Japan and Great Britain.