Contents

List of abbreviations ix Rare and salivary gland–type tumours

Introduction 139
Foreword x Acinic cell carcinoma 139
Adenoid cystic carcinoma 142
TNM staging of carcinomas of the breast 1 Secretory carcinoma 146
Mucoepidermoid carcinoma 149
1 Introduction to tumours of the breast 5 Polymorphous adenocarcinoma 151
Tall cell carcinoma with reversed polarity 153
2 Epithelial tumours of the breast 9 Neuroendocrine neoplasms
WHO classification of epithelial tumours of the breast 10 Introduction 155
Benign epithelial proliferations and precursors Neuroendocrine tumour 156
Introduction 11 Neuroendocrine carcinoma 159
Usual ductal hyperplasia 13
Columnar cell lesions, including flat epithelial atypia 15 3 Fibroepithelial tumours and hamartomas of the breast 163
Atypical ductal hyperplasia 18 WHO classification of fibroepithelial tumours and
Adenosis and benign sclerosing lesions hamartomas of the breast 164
Introduction 22 Introduction 165
Sclerosing adenosis 22 Hamartoma 166
Apocrine adenosis and adenoma 25 Fibroadenoma 168
Microglandular adenosis 28 Phyllodes tumour 172
Radial scar / complex sclerosing lesion 30
Adenomas 4 Tumours of the nipple 177
Introduction 32 WHO classification of tumours of the nipple 178
Tubular adenoma 32 Introduction 179
Lactating adenoma 35 Epithelial tumours
Ductal adenoma 37 Syringomatous tumour 180
Epithelial-myoepithelial tumours Nipple adenoma 182
Introduction 39 Paget disease of the breast 184
Pleomorphic adenoma 40
Adenomyoepithelioma 43 5 Mesenchymal tumours of the breast 187
Malignant adenomyoepithelioma 46 WHO classification of mesenchymal tumours of the breast 188
Papillary neoplasms Introduction 189
Introduction 49 Vascular tumours
Intraductal papilloma 52 Haemangioma 191
Papillary ductal carcinoma in situ 57 Angiomatosis 193
Encapsulated papillary carcinoma 60 Atypical vascular lesions 195
Solid papillary carcinoma (in situ and invasive) 63 Postradiation angiosarcoma of the breast 197
Invasive papillary carcinoma 66 Primary angiosarcoma of the breast 200
Non-invasive lobular neoplasia Fibroblastic and myofibroblastic tumours
Introduction 68 Nodular fasciitis 202
Atypical lobular hyperplasia 68 Myofibroblastoma 204
Lobular carcinoma in situ 71 Desmoid fibromatosis 206
Ductal carcinoma in situ Inflammatory myofibroblastic tumour 209
Introduction 75 Peripheral nerve sheath tumours
Ductal carcinoma in situ 76 Schwannoma 211
Invasive breast carcinoma Neurofibroma 213
General overview 82 Granular cell tumour 215
Invasive breast carcinoma of no special type 102 Smooth muscle tumours
Microinvasive carcinoma 110 Leiomyoma 217
Invasive lobular carcinoma 114 Leiomyosarcoma 219
Tubular carcinoma 119 Adipocytic tumours
Cribriform carcinoma 121 Lipoma 221
Mucinous carcinoma 123 Angiolipoma 223
Mucinous cystadenocarcinoma 126 Liposarcoma 225
Invasive micropapillary carcinoma 128 Other mesenchymal tumours and tumour-like conditions
Carcinoma with apocrine differentiation 131 Pseudoangiomatous stromal hyperplasia 228
Metaplastic carcinoma 134
6 Haematolymphoid tumours of the breast 231 9 Genetic tumour syndromes of the breast 267
WHO classification of haematolymphoid tumours Introduction 268
of the breast 232 BRCA1/2-associated hereditary breast and ovarian cancer
Introduction 233 syndrome 270
Lymphoma Cowden syndrome 275
Extranodal marginal zone lymphoma of mucosa- Ataxia–telangiectasia 277
associated lymphoid tissue (MALT lymphoma) 235 Li–Fraumeni syndrome, TP53-associated 279
Follicular lymphoma 238 Li–Fraumeni syndrome, CHEK2-associated 282
Diffuse large B-cell lymphoma 240 CDH1-associated breast cancer 284
Burkitt lymphoma 242 PALB2-associated cancers 286
Breast implant–associated anaplastic large cell Peutz–Jeghers syndrome 288
lymphoma 245 Neurofibromatosis type 1 290
The polygenic component of breast cancer susceptibility 292
7 Tumours of the male breast 249
WHO classification of tumours of the male breast 250 Contributors299
Introduction 251
Epithelial tumours Declaration of interests 305
Gynaecomastia 252
Carcinoma in situ 255 IARC/WHO Committee for ICD-O 306
Invasive carcinoma 257
Sources307
8 Metastases to the breast 261
References311

Subject index 349

Previous volumes in the series 356