2022 Mayo Clinic 990 Public

DocuSign Envelope ID: C076B141-5831-41F8-93B6-4D4900FAAB1F
990 Return of Organization Exempt From Income Tax OMB No. 1545-0047
Form Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations)
Do not enter social security numbers on this form as it may be made public.
2022
Department of the Treasury Open to Public
Internal Revenue Service Go to www.irs.gov/Form990 for instructions and the latest information. Inspection
A For the 2022 calendar year, or tax year beginning and ending
B Check if C Name of organization D Employer identification number
applicable:
Address
change MAYO CLINIC
Name
change Doing business as 41-6011702
Initial
return Number and street (or P.O. box if mail is not delivered to street address) Room/suite E Telephone number
Final
return/ 200 FIRST STREET SW TAX 507-538-1297
termin-
ated City or town, state or province, country, and ZIP or foreign postal code G Gross receipts $ 14,473,593,274.
Amended
return ROCHESTER, MN 55905 H(a) Is this a group return
Applica-
tion F Name and address of principal officer: GIANRICO FARRUGIA, M.D. for subordinates? ~~ Yes X No
pending
SAME AS C ABOVE H(b) Are all subordinates included? Yes No
I Tax-exempt status: X 501(c)(3) 501(c) ( ) (insert no.) 4947(a)(1) or 527 If "No," attach a list. See instructions
J Website: WWW.MAYOCLINIC.ORG H(c) Group exemption number 5983
K Form of organization: X Corporation Trust Association Other L Year of formation: 1919 M State of legal domicile: MN
Part I Summary
1 Briefly describe the organization's mission or most significant activities: PATIENT CARE, RESEARCH AND
Activities & Governance
EDUCATION
2 Check this box if the organization discontinued its operations or disposed of more than 25% of its net assets.
3 Number of voting members of the governing body (Part VI, line 1a) ~~~~~~~~~~~~~~~~~~~~ 3 28
4 Number of independent voting members of the governing body (Part VI, line 1b) ~~~~~~~~~~~~~~ 4 16
5 Total number of individuals employed in calendar year 2022 (Part V, line 2a) ~~~~~~~~~~~~~~~~ 5 29136
6 Total number of volunteers (estimate if necessary) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6 928
7 a Total unrelated business revenue from Part VIII, column (C), line 12 ~~~~~~~~~~~~~~~~~~~~ 7a 916,217,531.
b Net unrelated business taxable income from Form 990-T, Part I, line 11 7b 122,337,721.
Prior Year Current Year
8 Contributions and grants (Part VIII, line 1h) ~~~~~~~~~~~~~~~~~~~~~ 2,825,326,266. 2,389,724,888.
Revenue
9 Program service revenue (Part VIII, line 2g) ~~~~~~~~~~~~~~~~~~~~~ 4,089,305,003. 4,050,774,292.
10 Investment income (Part VIII, column (A), lines 3, 4, and 7d) ~~~~~~~~~~~~~ 1,021,883,730. 592,500,111.
11 Other revenue (Part VIII, column (A), lines 5, 6d, 8c, 9c, 10c, and 11e) ~~~~~~~~ 56,726,005. 42,354,919.
12 Total revenue - add lines 8 through 11 (must equal Part VIII, column (A), line 12) 7,993,241,004. 7,075,354,210.
13 Grants and similar amounts paid (Part IX, column (A), lines 1-3) ~~~~~~~~~~~ 540,559,805. 323,566,414.
14 Benefits paid to or for members (Part IX, column (A), line 4) ~~~~~~~~~~~~~ 0. 0.
15 Salaries, other compensation, employee benefits (Part IX, column (A), lines 5-10) ~~~ 2,842,196,781. 3,087,079,075.
Expenses
16a Professional fundraising fees (Part IX, column (A), line 11e) ~~~~~~~~~~~~~~ 617,878. 902,800.
b Total fundraising expenses (Part IX, column (D), line 25) 51,238,052.
17 Other expenses (Part IX, column (A), lines 11a-11d, 11f-24e) ~~~~~~~~~~~~~ 2,389,744,925. 2,266,407,337.
18 Total expenses. Add lines 13-17 (must equal Part IX, column (A), line 25) ~~~~~~~ 5,773,119,389. 5,677,955,626.
19 Revenue less expenses. Subtract line 18 from line 12 2,220,121,615. 1,397,398,584.
Fund Balances
Beginning of Current Year End of Year

Net Assets or
20 Total assets (Part X, line 16) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 20,543,802,362. 22,107,639,425.

21 Total liabilities (Part X, line 26)
~~~~~~~~~~~~~~~~~~~~~~~~~~~ 10,166,049,837. 9,578,170,747.
22 Net assets or fund balances. Subtract line 21 from line 20 10,377,752,525. 12,529,468,678.
Part II Signature Block
Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is
true, correct, and complete. Declaration of preparer (other than officer) is based on all information of which preparer has any knowledge.
11/11/2023
Sign Signature of officer Date
Here DENNIS E. DAHLEN, CFO
Type or print name and title
Print/Type preparer's name Preparer's signature Date Check PTIN
if
Paid self-employed
Preparer Firm's name Firm's EIN
Use Only Firm's address
Phone no.
May the IRS discuss this return with the preparer shown above? See instructions Yes No
232001 12-13-22 LHA For Paperwork Reduction Act Notice, see the separate instructions. Form 990 (2022)
Form 990 (2022) MAYO CLINIC 41-6011702 Page 2
Part III Statement of Program Service Accomplishments
Check if Schedule O contains a response or note to any line in this Part III •••••••••••••••••••••••••••• X
1 Briefly describe the organization's mission:
TO INSPIRE HOPE AND CONTRIBUTE TO HEALTH AND WELL-BEING BY PROVIDING
THE BEST CARE TO EVERY PATIENT THROUGH INTEGRATED CLINICAL PRACTICE,
EDUCATION AND RESEARCH.
2 Did the organization undertake any significant program services during the year which were not listed on the
prior Form 990 or 990-EZ? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes X No
If "Yes," describe these new services on Schedule O.
3 Did the organization cease conducting, or make significant changes in how it conducts, any program services?~~~~~~ Yes X No
If "Yes," describe these changes on Schedule O.
4 Describe the organization's program service accomplishments for each of its three largest program services, as measured by expenses.
Section 501(c)(3) and 501(c)(4) organizations are required to report the amount of grants and allocations to others, the total expenses, and
revenue, if any, for each program service reported.
4a (Code: ) (Expenses $ 4,231,360,455. including grants of $ 253,195,203. ) (Revenue $ 4,023,668,447. )
PATIENT CARE (SEE SCHEDULE O FOR DESCRIPTION)
4b (Code: ) (Expenses $ 827,331,781. including grants of $ 41,977,512. ) (Revenue $ 8,006,602. )

MEDICAL RESEARCH (SEE SCHEDULE O FOR DESCRIPTION)
4c (Code: ) (Expenses $ 299,283,508. including grants of $ 28,393,698. ) (Revenue $ 45,139,476. )

MEDICAL EDUCATION (SEE SCHEDULE O FOR DESCRIPTION)
4d Other program services (Describe on Schedule O.)

(Expenses $ including grants of $ ) (Revenue $ )
4e Total program service expenses 5,357,975,744.
Form 990 (2022)
232002 12-13-22 SEE SCHEDULE O FOR CONTINUATION(S)
3
15101113 136378 MAYOCLINIC 2022.03050 MAYO CLINIC MAYOCLI1
Part IV Checklist of Required Schedules
Yes No
1 Is the organization described in section 501(c)(3) or 4947(a)(1) (other than a private foundation)?
If "Yes," complete Schedule A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1 X
2 Is the organization required to complete Schedule B, Schedule of Contributors? See instructions ~~~~~~~~~~~~~~ 2 X
3 Did the organization engage in direct or indirect political campaign activities on behalf of or in opposition to candidates for
public office? If "Yes," complete Schedule C, Part I ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3 X
4 Section 501(c)(3) organizations. Did the organization engage in lobbying activities, or have a section 501(h) election in effect
during the tax year? If "Yes," complete Schedule C, Part II ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4 X
5 Is the organization a section 501(c)(4), 501(c)(5), or 501(c)(6) organization that receives membership dues, assessments, or
similar amounts as defined in Rev. Proc. 98-19? If "Yes," complete Schedule C, Part III ~~~~~~~~~~~~~~~~~~~ 5 X
6 Did the organization maintain any donor advised funds or any similar funds or accounts for which donors have the right to
provide advice on the distribution or investment of amounts in such funds or accounts? If "Yes," complete Schedule D, Part I 6 X
7 Did the organization receive or hold a conservation easement, including easements to preserve open space,
the environment, historic land areas, or historic structures? If "Yes," complete Schedule D, Part II~~~~~~~~~~~~~~ 7 X
8 Did the organization maintain collections of works of art, historical treasures, or other similar assets? If "Yes," complete
Schedule D, Part III ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 8 X
9 Did the organization report an amount in Part X, line 21, for escrow or custodial account liability, serve as a custodian for
amounts not listed in Part X; or provide credit counseling, debt management, credit repair, or debt negotiation services?
If "Yes," complete Schedule D, Part IV ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 9 X
10 Did the organization, directly or through a related organization, hold assets in donor-restricted endowments
or in quasi endowments? If "Yes," complete Schedule D, Part V ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 10 X
11 If the organization's answer to any of the following questions is "Yes," then complete Schedule D, Parts VI, VII, VIII, IX, or X,
as applicable.
a Did the organization report an amount for land, buildings, and equipment in Part X, line 10? If "Yes," complete Schedule D,
Part VI ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 11a X
b Did the organization report an amount for investments - other securities in Part X, line 12, that is 5% or more of its total
assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VII ~~~~~~~~~~~~~~~~~~~~~~~~~ 11b X
c Did the organization report an amount for investments - program related in Part X, line 13, that is 5% or more of its total
assets reported in Part X, line 16? If "Yes," complete Schedule D, Part VIII ~~~~~~~~~~~~~~~~~~~~~~~~~ 11c X
d Did the organization report an amount for other assets in Part X, line 15, that is 5% or more of its total assets reported in
Part X, line 16? If "Yes," complete Schedule D, Part IX ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 11d X
e Did the organization report an amount for other liabilities in Part X, line 25? If "Yes," complete Schedule D, Part X ~~~~~~ 11e X
f Did the organization's separate or consolidated financial statements for the tax year include a footnote that addresses
the organization's liability for uncertain tax positions under FIN 48 (ASC 740)? If "Yes," complete Schedule D, Part X ~~~~ 11f X
12a Did the organization obtain separate, independent audited financial statements for the tax year? If "Yes," complete
Schedule D, Parts XI and XII ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 12a X
b Was the organization included in consolidated, independent audited financial statements for the tax year?
If "Yes," and if the organization answered "No" to line 12a, then completing Schedule D, Parts XI and XII is optional ~~~~~ 12b X
13 Is the organization a school described in section 170(b)(1)(A)(ii)? If "Yes," complete Schedule E ~~~~~~~~~~~~~~ 13 X
14a Did the organization maintain an office, employees, or agents outside of the United States? ~~~~~~~~~~~~~~~~ 14a X
b Did the organization have aggregate revenues or expenses of more than $10,000 from grantmaking, fundraising, business,
investment, and program service activities outside the United States, or aggregate foreign investments valued at $100,000
or more? If "Yes," complete Schedule F, Parts I and IV ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 14b X
15 Did the organization report on Part IX, column (A), line 3, more than $5,000 of grants or other assistance to or for any
foreign organization? If "Yes," complete Schedule F, Parts II and IV ~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 15 X
16 Did the organization report on Part IX, column (A), line 3, more than $5,000 of aggregate grants or other assistance to
or for foreign individuals? If "Yes," complete Schedule F, Parts III and IV ~~~~~~~~~~~~~~~~~~~~~~~~~~ 16 X
17 Did the organization report a total of more than $15,000 of expenses for professional fundraising services on Part IX,
column (A), lines 6 and 11e? If "Yes," complete Schedule G, Part I. See instructions ~~~~~~~~~~~~~~~~~~~~ 17 X
18 Did the organization report more than $15,000 total of fundraising event gross income and contributions on Part VIII, lines
1c and 8a? If "Yes," complete Schedule G, Part II ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 18 X
19 Did the organization report more than $15,000 of gross income from gaming activities on Part VIII, line 9a? If "Yes,"
complete Schedule G, Part III ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 19 X
20a Did the organization operate one or more hospital facilities? If "Yes," complete Schedule H ~~~~~~~~~~~~~~~~~ 20a X
b If "Yes" to line 20a, did the organization attach a copy of its audited financial statements to this return? ~~~~~~~~~~ 20b
21 Did the organization report more than $5,000 of grants or other assistance to any domestic organization or
domestic government on Part IX, column (A), line 1? If "Yes," complete Schedule I, Parts I and II ~~~~~~~~~~~~~~
•••••••••••••• 21 X
232003 12-13-22 Form 990 (2022)
4
Part IV Checklist of Required Schedules (continued)
Yes No
22 Did the organization report more than $5,000 of grants or other assistance to or for domestic individuals on
Part IX, column (A), line 2? If "Yes," complete Schedule I, Parts I and III ~~~~~~~~~~~~~~~~~~~~~~~~~~ 22 X
23 Did the organization answer "Yes" to Part VII, Section A, line 3, 4, or 5, about compensation of the organization's current
and former officers, directors, trustees, key employees, and highest compensated employees? If "Yes," complete
Schedule J ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 23 X
24 a Did the organization have a tax-exempt bond issue with an outstanding principal amount of more than $100,000 as of the
last day of the year, that was issued after December 31, 2002? If "Yes," answer lines 24b through 24d and complete
Schedule K. If "No," go to line 25a ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 24a X
b Did the organization invest any proceeds of tax-exempt bonds beyond a temporary period exception? ~~~~~~~~~~~ 24b X
c Did the organization maintain an escrow account other than a refunding escrow at any time during the year to defease
any tax-exempt bonds? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 24c X
d Did the organization act as an "on behalf of" issuer for bonds outstanding at any time during the year? ~~~~~~~~~~~ 24d X
25 a Section 501(c)(3), 501(c)(4), and 501(c)(29) organizations. Did the organization engage in an excess benefit
transaction with a disqualified person during the year? If "Yes," complete Schedule L, Part I ~~~~~~~~~~~~~~~~ 25a X
b Is the organization aware that it engaged in an excess benefit transaction with a disqualified person in a prior year, and
that the transaction has not been reported on any of the organization's prior Forms 990 or 990-EZ? If "Yes," complete
Schedule L, Part I ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 25b X
26 Did the organization report any amount on Part X, line 5 or 22, for receivables from or payables to any current
or former officer, director, trustee, key employee, creator or founder, substantial contributor, or 35%
controlled entity or family member of any of these persons? If "Yes," complete Schedule L, Part II ~~~~~~~~~~~~~ 26 X
27 Did the organization provide a grant or other assistance to any current or former officer, director, trustee, key employee,
creator or founder, substantial contributor or employee thereof, a grant selection committee member, or to a 35% controlled
entity (including an employee thereof) or family member of any of these persons? If "Yes," complete Schedule L, Part III~~~ 27 X
28 Was the organization a party to a business transaction with one of the following parties (see the Schedule L, Part IV,
instructions for applicable filing thresholds, conditions, and exceptions):
a A current or former officer, director, trustee, key employee, creator or founder, or substantial contributor? If
"Yes," complete Schedule L, Part IV ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 28a X
b A family member of any individual described in line 28a? If "Yes," complete Schedule L, Part IV~~~~~~~~~~~~~~~ 28b X
c A 35% controlled entity of one or more individuals and/or organizations described in line 28a or 28b? If
"Yes," complete Schedule L, Part IV ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 28c X
29 Did the organization receive more than $25,000 in non-cash contributions? If "Yes," complete Schedule M ~~~~~~~~~ 29 X
30 Did the organization receive contributions of art, historical treasures, or other similar assets, or qualified conservation
contributions? If "Yes," complete Schedule M ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 30 X
31 Did the organization liquidate, terminate, or dissolve and cease operations? If "Yes," complete Schedule N, Part I~~~~~~ 31 X
32 Did the organization sell, exchange, dispose of, or transfer more than 25% of its net assets? If "Yes," complete
Schedule N, Part II ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 32 X
33 Did the organization own 100% of an entity disregarded as separate from the organization under Regulations
sections 301.7701-2 and 301.7701-3? If "Yes," complete Schedule R, Part I ~~~~~~~~~~~~~~~~~~~~~~~~ 33 X
34 Was the organization related to any tax-exempt or taxable entity? If "Yes," complete Schedule R, Part II, III, or IV, and
Part V, line 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 34 X
35 a Did the organization have a controlled entity within the meaning of section 512(b)(13)? ~~~~~~~~~~~~~~~~~~ 35a X
b If "Yes" to line 35a, did the organization receive any payment from or engage in any transaction with a controlled entity
within the meaning of section 512(b)(13)? If "Yes," complete Schedule R, Part V, line 2 ~~~~~~~~~~~~~~~~~~~ 35b X
36 Section 501(c)(3) organizations. Did the organization make any transfers to an exempt non-charitable related organization?
If "Yes," complete Schedule R, Part V, line 2 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 36 X
37 Did the organization conduct more than 5% of its activities through an entity that is not a related organization
and that is treated as a partnership for federal income tax purposes? If "Yes," complete Schedule R, Part VI ~~~~~~~~ 37 X
38 Did the organization complete Schedule O and provide explanations on Schedule O for Part VI, lines 11b and 19?
Note: All Form 990 filers are required to complete Schedule O ••••••••••••••••••••••••••••••• 38 X
Part V Statements Regarding Other IRS Filings and Tax Compliance
Check if Schedule O contains a response or note to any line in this Part V ••••••••••••••••••••••••••• X
Yes No
1a Enter the number reported in box 3 of Form 1096. Enter -0- if not applicable ~~~~~~~~~~~ 1a 1286
b Enter the number of Forms W-2G included on line 1a. Enter -0- if not applicable~~~~~~~~~~ 1b 0
c Did the organization comply with backup withholding rules for reportable payments to vendors and reportable gaming
(gambling) winnings to prize winners? ••••••••••••••••••••••••••••••••••••••••••• 1c X
232004 12-13-22 Form 990 (2022)
5
Part V Statements Regarding Other IRS Filings and Tax Compliance (continued)
Yes No
2a Enter the number of employees reported on Form W-3, Transmittal of Wage and Tax Statements,
filed for the calendar year ending with or within the year covered by this return ~~~~~~~~~~ 2a 29136
b If at least one is reported on line 2a, did the organization file all required federal employment tax returns?~~~~~~~~~~ 2b X
3a Did the organization have unrelated business gross income of $1,000 or more during the year? ~~~~~~~~~~~~~~ 3a X
b If "Yes," has it filed a Form 990-T for this year? If "No" to line 3b, provide an explanation on Schedule O ~~~~~~~~~~ 3b X
4a At any time during the calendar year, did the organization have an interest in, or a signature or other authority over, a
financial account in a foreign country (such as a bank account, securities account, or other financial account)?~~~~~~~ 4a X
b If "Yes," enter the name of the foreign country SEE SCHEDULE O
See instructions for filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBAR).
5a Was the organization a party to a prohibited tax shelter transaction at any time during the tax year? ~~~~~~~~~~~~ 5a X
b Did any taxable party notify the organization that it was or is a party to a prohibited tax shelter transaction?~~~~~~~~~ 5b X
c If "Yes" to line 5a or 5b, did the organization file Form 8886-T?~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5c
6a Does the organization have annual gross receipts that are normally greater than $100,000, and did the organization solicit
any contributions that were not tax deductible as charitable contributions? ~~~~~~~~~~~~~~~~~~~~~~~~ 6a X
b If "Yes," did the organization include with every solicitation an express statement that such contributions or gifts
were not tax deductible? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6b
7 Organizations that may receive deductible contributions under section 170(c).
a Did the organization receive a payment in excess of $75 made partly as a contribution and partly for goods and services provided to the payor? 7a X
b If "Yes," did the organization notify the donor of the value of the goods or services provided? ~~~~~~~~~~~~~~~ 7b
c Did the organization sell, exchange, or otherwise dispose of tangible personal property for which it was required
to file Form 8282? •••••••••••••••••••••••••••••••••••••••••••••••••••• 7c X
d If "Yes," indicate the number of Forms 8282 filed during the year ~~~~~~~~~~~~~~~~ 7d
e Did the organization receive any funds, directly or indirectly, to pay premiums on a personal benefit contract? ~~~~~~~ 7e X
f Did the organization, during the year, pay premiums, directly or indirectly, on a personal benefit contract? ~~~~~~~~~ 7f X
g If the organization received a contribution of qualified intellectual property, did the organization file Form 8899 as required?~ 7g
h If the organization received a contribution of cars, boats, airplanes, or other vehicles, did the organization file a Form 1098-C? 7h
8 Sponsoring organizations maintaining donor advised funds. Did a donor advised fund maintained by the
sponsoring organization have excess business holdings at any time during the year? ~~~~~~~~~~~~~~~~~~~ 8 X
9 Sponsoring organizations maintaining donor advised funds.
a Did the sponsoring organization make any taxable distributions under section 4966? ~~~~~~~~~~~~~~~~~~~ 9a X
b Did the sponsoring organization make a distribution to a donor, donor advisor, or related person? ~~~~~~~~~~~~~ 9b X
10 Section 501(c)(7) organizations. Enter:
a Initiation fees and capital contributions included on Part VIII, line 12 ~~~~~~~~~~~~~~~ 10a
b Gross receipts, included on Form 990, Part VIII, line 12, for public use of club facilities ~~~~~~ 10b
11 Section 501(c)(12) organizations. Enter:
a Gross income from members or shareholders ~~~~~~~~~~~~~~~~~~~~~~~~~~ 11a
b Gross income from other sources. (Do not net amounts due or paid to other sources against
amounts due or received from them.) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 11b
12a Section 4947(a)(1) non-exempt charitable trusts. Is the organization filing Form 990 in lieu of Form 1041? 12a
b If "Yes," enter the amount of tax-exempt interest received or accrued during the year •••••• 12b
13 Section 501(c)(29) qualified nonprofit health insurance issuers.
a Is the organization licensed to issue qualified health plans in more than one state? ~~~~~~~~~~~~~~~~~~~~~ 13a
Note: See the instructions for additional information the organization must report on Schedule O.
b Enter the amount of reserves the organization is required to maintain by the states in which the
organization is licensed to issue qualified health plans ~~~~~~~~~~~~~~~~~~~~~~ 13b
c Enter the amount of reserves on hand ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 13c
14a Did the organization receive any payments for indoor tanning services during the tax year? ~~~~~~~~~~~~~~~~ 14a X
b If "Yes," has it filed a Form 720 to report these payments? If "No," provide an explanation on Schedule O ~~~~~~~~~ 14b
15 Is the organization subject to the section 4960 tax on payment(s) of more than $1,000,000 in remuneration or
excess parachute payment(s) during the year?~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 15 X
If "Yes," see the instructions and file Form 4720, Schedule N.
16 Is the organization an educational institution subject to the section 4968 excise tax on net investment income? ~~~~~~ 16 X
If "Yes," complete Form 4720, Schedule O.
17 Section 501(c)(21) organizations. Did the trust, or any disqualified or other person engage in any activities
that would result in the imposition of an excise tax under section 4951, 4952 or 4953? ~~~~~~~~~~~~~~~~~~~ 17
If "Yes," complete Form 6069.
232005 12-13-22 Form 990 (2022)
6
Part VI Governance, Management, and Disclosure. For each "Yes" response to lines 2 through 7b below, and for a "No" response
to line 8a, 8b, or 10b below, describe the circumstances, processes, or changes on Schedule O. See instructions.
Check if Schedule O contains a response or note to any line in this Part VI ••••••••••••••••••••••••••• X
Section A. Governing Body and Management
Yes No
1a Enter the number of voting members of the governing body at the end of the tax year ~~~~~~ 1a 28
If there are material differences in voting rights among members of the governing body, or if the governing
body delegated broad authority to an executive committee or similar committee, explain on Schedule O.
b Enter the number of voting members included on line 1a, above, who are independent ~~~~~~ 1b 16
2 Did any officer, director, trustee, or key employee have a family relationship or a business relationship with any other
officer, director, trustee, or key employee? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2 X
3 Did the organization delegate control over management duties customarily performed by or under the direct supervision
of officers, directors, trustees, or key employees to a management company or other person? ~~~~~~~~~~~~~~~ 3 X
4 Did the organization make any significant changes to its governing documents since the prior Form 990 was filed? ~~~~~ 4 X
5 Did the organization become aware during the year of a significant diversion of the organization's assets? ~~~~~~~~~ 5 X
6 Did the organization have members or stockholders? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6 X
7a Did the organization have members, stockholders, or other persons who had the power to elect or appoint one or
more members of the governing body? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7a X
b Are any governance decisions of the organization reserved to (or subject to approval by) members, stockholders, or
persons other than the governing body? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7b X
8 Did the organization contemporaneously document the meetings held or written actions undertaken during the year by the following:
a The governing body? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 8a X
b Each committee with authority to act on behalf of the governing body? ~~~~~~~~~~~~~~~~~~~~~~~~~~ 8b X
9 Is there any officer, director, trustee, or key employee listed in Part VII, Section A, who cannot be reached at the
organization's mailing address? If "Yes," provide the names and addresses on Schedule O ••••••••••••••••• 9 X
Section B. Policies (This Section B requests information about policies not required by the Internal Revenue Code.)
Yes No
10a Did the organization have local chapters, branches, or affiliates? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 10a X
b If "Yes," did the organization have written policies and procedures governing the activities of such chapters, affiliates,
and branches to ensure their operations are consistent with the organization's exempt purposes? ~~~~~~~~~~~~~ 10b X
11a Has the organization provided a complete copy of this Form 990 to all members of its governing body before filing the form? 11a X
b Describe on Schedule O the process, if any, used by the organization to review this Form 990.
12a Did the organization have a written conflict of interest policy? If "No," go to line 13 ~~~~~~~~~~~~~~~~~~~~~ 12a X
b Were officers, directors, or trustees, and key employees required to disclose annually interests that could give rise to conflicts? ~~~~~~ 12b X
c Did the organization regularly and consistently monitor and enforce compliance with the policy? If "Yes," describe
on Schedule O how this was done ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 12c X
13 Did the organization have a written whistleblower policy? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 13 X
14 Did the organization have a written document retention and destruction policy? ~~~~~~~~~~~~~~~~~~~~~~ 14 X
15 Did the process for determining compensation of the following persons include a review and approval by independent
persons, comparability data, and contemporaneous substantiation of the deliberation and decision?
a The organization's CEO, Executive Director, or top management official ~~~~~~~~~~~~~~~~~~~~~~~~~~ 15a X
b Other officers or key employees of the organization ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 15b X
If "Yes" to line 15a or 15b, describe the process on Schedule O. See instructions.
16a Did the organization invest in, contribute assets to, or participate in a joint venture or similar arrangement with a
taxable entity during the year? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 16a X
b If "Yes," did the organization follow a written policy or procedure requiring the organization to evaluate its participation
in joint venture arrangements under applicable federal tax law, and take steps to safeguard the organization's
exempt status with respect to such arrangements? •••••••••••••••••••••••••••••••••••• 16b X
Section C. Disclosure
17 List the states with which a copy of this Form 990 is required to be filed SEE SCHEDULE O
18 Section 6104 requires an organization to make its Forms 1023 (1024 or 1024-A, if applicable), 990, and 990-T (section 501(c)(3)s only) available
for public inspection. Indicate how you made these available. Check all that apply.
Own website Another's website X Upon request Other (explain on Schedule O)
19 Describe on Schedule O whether (and if so, how) the organization made its governing documents, conflict of interest policy, and financial
statements available to the public during the tax year.
20 State the name, address, and telephone number of the person who possesses the organization's books and records
CORPORATE TAX - 507-538-1297
200 FIRST STREET SW, ROCHESTER, MN 55905
232006 12-13-22 Form 990 (2022)
7
Part VII Compensation of Officers, Directors, Trustees, Key Employees, Highest Compensated
Employees, and Independent Contractors
Check if Schedule O contains a response or note to any line in this Part VII •••••••••••••••••••••••••••
Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees
1a Complete this table for all persons required to be listed. Report compensation for the calendar year ending with or within the organization's tax year.
¥ List all of the organization's current officers, directors, trustees (whether individuals or organizations), regardless of amount of compensation.
Enter -0- in columns (D), (E), and (F) if no compensation was paid.
¥ List all of the organization's current key employees, if any. See the instructions for definition of "key employee."
¥ List the organization's five current highest compensated employees (other than an officer, director, trustee, or key employee)
who received reportable compensation (box 5 of Form W-2, box 6 of Form 1099-MISC, and/or box 1 of Form 1099-NEC) of more than
$100,000 from the organization and any related organizations.
¥ List all of the organization's former officers, key employees, and highest compensated employees who received more than $100,000 of
reportable compensation from the organization and any related organizations.
¥ List all of the organization's former directors or trustees that received, in the capacity as a former director or trustee of the organization,
more than $10,000 of reportable compensation from the organization and any related organizations.
See the instructions for the order in which to list the persons above.
Check this box if neither the organization nor any related organization compensated any current officer, director, or trustee.
(A) (B) (C) (D) (E) (F)
Name and title Average Position Reportable Reportable Estimated
(do not check more than one
hours per box, unless person is both an compensation compensation amount of
officer and a director/trustee)
week Individual trustee or director from from related other
(list any the organizations compensation
hours for organization (W-2/1099-MISC/ from the
Highest compensated
Institutional trustee
related (W-2/1099-MISC/ 1099-NEC) organization

organizations 1099-NEC) Key employee and related
employee
below organizations
Former
Officer
line)
FARRUGIA M.D., GIANRICO 1.00
TRUSTEE/PRESIDENT/CEO 40.00 X X 0. 3,636,091. 84,251.
GRAY M.D., RICHARD J. 1.00
TRUSTEE/VP 40.00 X X 0. 1,999,424. 73,274.
THIELEN M.D., KENT R. 1.00
TRUSTEE/VP 40.00 X X 0. 2,006,672. 82,342.
GORMAN, PAUL A. 1.00
TREASURER 40.00 X 0. 1,715,056. 86,692.
ZORN, CHRISTINA K. 1.00
TRUSTEE/VP 40.00 X X 0. 1,530,674. 71,810.
DAHLEN, DENNIS E. 1.00
CFO 40.00 X 0. 1,481,402. 92,474.
KRAUSS M.D., WILLIAM E. 40.00
PHYSICIAN 0.00 X 1,463,000. 0. 76,257.
LANZINO M.D., GIUSEPPE 40.00
PHYSICIAN 0.00 X 1,452,631. 0. 78,463.
MURPHY, JOSHUA B. 1.00
SECY 40.00 X 0. 1,402,046. 83,935.
PICHELMANN M.D., MARK A. 40.00
CHAIR-NWWI NEUROSURGERY 0.00 X 1,405,818. 0. 64,961.
WILLIAMS M.D., AMY W. 1.00
TRUSTEE 40.00 X 0. 1,397,374. 72,259.
MARSH M.D., W. RICHARD 40.00
DIR-SPINE CENTER 0.00 X 1,378,411. 0. 39,627.
CLARKE M.D., MICHELLE J. 40.00
PHYSICIAN 0.00 X 1,327,940. 0. 53,586.
GORES M.D., GREGORY J. 40.00
EXECUTIVE DEAN OF RESEARCH 0.00 X 1,301,223. 0. 39,974.
WILLIAMSON, MARY J. 40.00
CAO-MCS 0.00 X 1,096,580. 0. 78,248.
OTLEY M.D., CLARK C. 40.00
PHYSICIAN 0.00 X 1,078,010. 0. 81,918.
AMMASH M.D., NASER M. 0.00
FORMER KEY EMPLOYEE 40.00 X 0. 1,036,062. 75,598.
232007 12-13-22 Form 990 (2022)
8
Part VII Section A. Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees (continued)
(A) (B) (C) (D) (E) (F)
(do not check more than one
hours per box, unless person is both an compensation compensation amount of
officer and a director/trustee)
week from from related other
(list any
Individual trustee or director

the organizations compensation
hours for organization (W-2/1099-MISC/ from the
Highest compensated
related
(W-2/1099-MISC/ 1099-NEC) organization
organizations 1099-NEC) and related
Key employee
below
employee
organizations
Former
Officer
line)
MENKOSKY, PAULA E. 1.00
ASST SECY 40.00 X 0. 1,011,448. 81,544.
HARPER JR., M.D., CHARLES M. 40.00
TRUSTEE 0.00 X 1,042,860. 0. 38,634.
PAGNANO M.D., MARK W. 40.00
CHAIR-ORTHOPEDICS 0.00 X 923,369. 0. 81,668.
SHAH M.D., VIJAY 40.00
CHAIR-ROCH INTERN MED 0.00 X 930,719. 0. 73,536.
CALLSTROM M.D., MATTHEW R. 40.00
TRUSTEE 0.00 X 920,062. 0. 78,978.
RIHAL M.D., CHARANJIT S. 40.00
TRUSTEE 0.00 X 901,460. 0. 84,702.
MORICE M.D., WILLIAM G. 40.00
CHAIR-LAB MED & PATH 0.00 X 866,742. 0. 78,296.
ARNETT, JENNIFER P. 40.00
CHIEF DEVELOPMENT OFFICER 0.00 X 877,526. 0. 36,563.
HARA M.D., AMY K. 1.00
TRUSTEE 40.00 X 0. 817,162. 74,377.
1b Subtotal ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 16,966,351. 18,033,411. 1,863,967.
c Total from continuation sheets to Part VII, Section A ~~~~~~~~~~~ 15,922,829. 5,395,612. 2,151,643.
d Total (add lines 1b and 1c) ••••••••••••••••••••••~•• 32,889,180. 23,429,023. 4,015,610.
2 Total number of individuals (including but not limited to those listed above) who received more than $100,000 of reportable
compensation from the organization 6,603
Yes No
3 Did the organization list any former officer, director, trustee, key employee, or highest compensated employee on
line 1a? If "Yes," complete Schedule J for such individual ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3 X
4 For any individual listed on line 1a, is the sum of reportable compensation and other compensation from the organization
and related organizations greater than $150,000? If "Yes," complete Schedule J for such individual~~~~~~~~~~~~~ 4 X
5 Did any person listed on line 1a receive or accrue compensation from any unrelated organization or individual for services
rendered to the organization? If "Yes," complete Schedule J for such person •••••••••••••••••••••••• 5 X
Section B. Independent Contractors
1 Complete this table for your five highest compensated independent contractors that received more than $100,000 of compensation from
the organization. Report compensation for the calendar year ending with or within the organization's tax year.
(A) (B) (C)
Name and business address Description of services Compensation
MAYO FOUNDATION FOR MEDICAL EDUCATION & RES PROCUREMENT & MED SUPPORT
200 FIRST STREET SW, ROCHESTER, MN 55905 SERVICES 615,782,948.
MAYO CLINIC JACKSONVILLE
4500 SAN PABLO ROAD, JACKSONVILLE, FL 32224 MEDICAL SUPPORT SERVICES 3,766,309.
2 Total number of independent contractors (including but not limited to those listed above) who received more than
$100,000 of compensation from the organization 2
SEE PART VII, SECTION A CONTINUATION SHEETS Form 990 (2022)
232008 12-13-22
9
Form 990 MAYO CLINIC 41-6011702
(A) (B) (C) (D) (E) (F)
hours (check all that apply) compensation compensation amount of
per from from related other
week the organizations compensation
Highest compensated employee

(list any organization (W-2/1099-MISC) from the
hours for (W-2/1099-MISC) organization
related and related
Key employee
organizations organizations
below
Former
Officer
line)
CAMILLERI M.D., MICHAEL 40.00
FORMER KEY EMPLOYEE 0.00 X 841,962. 0. 41,116.
WALD M.D., JOHN T. 40.00
KENDRICK M.D., MICHAEL L. 40.00
CHAIR-SURGERY 0.00 X 787,711. 0. 73,225.
KHAN, RITA G. 0.00
FORMER KEY EMPLOYEE 40.00 X 0. 758,025. 58,776.
FONSECA M.D., RAFAEL 1.00
TRUSTEE 40.00 X 0. 734,769. 78,773.
LEIBOVICH M.D., BRADLEY C. 40.00
PHYSICIAN 0.00 X 734,499. 0. 75,874.
DOWDY M.D., SEAN C. 40.00
CHIEF VALUE OFFICER 0.00 X 732,595. 0. 70,342.
LOFTUS M.D., CONOR G. 40.00
DIDEHBAN, ROSHANAK 1.00
TRUSTEE 40.00 X 489,841. 246,295. 36,358.
GALANIS M.D., EVANTHIA 40.00
EXECUTIVE DEAN OF DEVELOPMENT 0.00 X 696,670. 0. 70,863.
GERTZ M.D., MORIE A. 40.00
MCLAUGHLIN M.D., SARAH A. 1.00
TRUSTEE 40.00 X 0. 682,925. 35,344.
BROWN M.D., MICHAEL J. 40.00
PHYSICIAN 0.00 X 644,181. 0. 73,027.
CIMA M.D., ROBERT R. 40.00
PHYSICIAN 0.00 X 640,358. 0. 74,102.
OKUNO M.D., SCOTT H. 40.00
LUETMER M.D., PATRICK H. 40.00
FRANK M.D., IGOR 40.00
PHYSICIAN 0.00 X 631,768. 0. 67,305.
KHAN M.D., AMIR R. 40.00
PHYSICIAN 0.00 X 603,303. 0. 73,915.
PETERS M.D., STEVE G. 40.00
PHYSICIAN 0.00 X 614,018. 0. 40,312.
GAZELKA M.D., HALENA M. 1.00
FORMER KEY EMPLOYEE 40.00 X 584,084. 21,184. 56,096.
Total to Part VII, Section A, line 1c •••••••••••••••••••••••••
232201
04-01-22
10
(A) (B) (C) (D) (E) (F)

related and related
Key employee
below
Former
Officer
line)
FAMUYIDE M.B.B.S., ABIMBOLA O. 40.00
TRUSTEE 0.00 X 565,818. 0. 74,824.
FRANCIS, JAMES R. 1.00
ASST TREASURER 40.00 X 0. 547,728. 89,905.
HORLOCKER M.D., TERESE T. 40.00
PHYSICIAN 0.00 X 593,169. 0. 38,669.
DUNN, AJANI N. 1.00
ASST SECY 40.00 X 0. 535,956. 64,190.
HAYES M.D., SHARONNE N. 40.00
LUCCHINETTI M.D., CLAUDIA F. 40.00
TRUSTEE 0.00 X 490,858. 0. 77,982.
DIETER, HEIDI L. 40.00
CHAIR-RESEARCH ADMIN 0.00 X 490,358. 0. 50,076.
POE, JOHN D. 1.00
CHAIR-EDUCATION ADMIN 40.00 X 53,273. 408,559. 61,725.
DIASIO M.D., ROBERT B. 40.00
HUBERT, SHERRY L. 1.00
ASST SECY 40.00 X 0. 386,410. 83,003.
NARR M.D., BRADLY J. 40.00
NORBY, SUSAN M. 0.00
FORMER OFFICER 40.00 X 0. 364,249. 72,191.
BOLTON, JEFFREY W. 0.00
FORMER OFFICER 40.00 X 0. 406,549. 0.
CAINE, NATALIE A. 40.00
CAO-ROCHESTER 0.00 X 343,552. 0. 57,644.
GREENE M.D., EDDIE L. 40.00
TRUSTEE 0.00 X 315,382. 0. 66,907.
BROWN, WILLIAM A. 1.00
ASST TREASURER 40.00 X 0. 270,854. 37,597.
HAEFLINGER, RICKY J. 40.00
FORMER OFFICER 0.00 X 175,431. 0. 0.
ALIX, JAY 5.00
TRUSTEE 0.00 X 0. 13,491. 0.
POWELL, MICHAEL K. 5.00
TRUSTEE/CHAIR 0.00 X X 0. 9,137. 0.
STEER M.D., RANDOLPH C. 5.00
TRUSTEE 0.00 X 0. 3,881. 0.
Total to Part VII, Section A, line 1c •••••••••••••••••••••••••
232201
04-01-22
11
(A) (B) (C) (D) (E) (F)

related and related
Key employee
below
Former
Officer
line)
ROBERTS, ROBIN R. 5.00
TRUSTEE 0.00 X 0. 2,529. 0.
BAKER JR., DOUGLAS M. 5.00
TRUSTEE 0.00 X 0. 2,360. 0.
BAICKER, KATHERINE 5.00
TRUSTEE 0.00 X 0. 711. 0.
BILICIC, GEORGE W. 5.00
TRUSTEE 0.00 X 0. 0. 0.
BURNS, URSULA M. 5.00
TRUSTEE 0.00 X 0. 0. 0.
DAVIS, RICHARD K. 5.00
TRUSTEE 0.00 X 0. 0. 0.
DI PIAZZA JR., SAMUEL A. 5.00
TRUSTEE 0.00 X 0. 0. 0.
GERBERDING M.D., JULIE L. 5.00
TRUSTEE 0.00 X 0. 0. 0.
HALVORSON, GEORGE C. 5.00
TRUSTEE 0.00 X 0. 0. 0.
MULALLY, ALAN R. 5.00
TRUSTEE 0.00 X 0. 0. 0.
PERETSMAN, NANCY B. 5.00
TRUSTEE 0.00 X 0. 0. 0.
ROTHBLATT A., MARTINE 5.00
TRUSTEE 0.00 X 0. 0. 0.
SCHMIDT, ERIC E. 5.00
TRUSTEE 0.00 X 0. 0. 0.
SWEENEY, ANNE M. 5.00
TRUSTEE 0.00 X 0. 0. 0.
TOMM, CHARLES B. 5.00
TRUSTEE 0.00 X 0. 0. 0.
Total to Part VII, Section A, line 1c ••••••••••••••••••••••••• 15,922,829. 5,395,612. 2,151,643.
232201
04-01-22
12
Part VIII Statement of Revenue
Check if Schedule O contains a response or note to any line in this Part VIII •••••••••••••••••••••••••
(A) (B) (C) (D)
Total revenue Related or exempt Unrelated Revenue excluded
function revenue business revenue from tax under
sections 512 - 514
36,239.
Contributions, Gifts, Grants
and Other Similar Amounts
1 a Federated campaigns ~~~~~ 1a

b Membership dues ~~~~~~~ 1b
c Fundraising events ~~~~~~~ 1c
d Related organizations ~~~~~ 1d 1,309,186,490.
e Government grants (contributions) 1e 343,975,717.
f All other contributions, gifts, grants, and
similar amounts not included above ~ 1f 736,526,442.
g 1g $ 35,388,697.
Noncash contributions included in lines 1a-1f
h Total. Add lines 1a-1f •••••••••••••••••• 2,389,724,888.

Business Code
2 a NET PATIENT CARE 621110 3,997,628,214. 3,115,612,537. 882,015,677.
Program Service
b EDUCATION 611600 45,139,476. 45,139,476.

Revenue
c RESEARCH 541700 8,006,602. 4,731,275. 3,275,327.

d
e
f All other program service revenue ~~~~~
g Total. Add lines 2a-2f ••••••••••••••••••• 4,050,774,292.
3 Investment income (including dividends, interest, and
other similar amounts) ~~~~~~~~~~~~~~~~~~ 261,075,079. 23,500,921. 237,574,158.
4 Income from investment of tax-exempt bond proceeds 810,555. 810,555.
5 Royalties ••••••••••••••••••••••••• 13,332,077. 13,332,077.
(i) Real (ii) Personal
6 a Gross rents ~~~~~ 6a 1,367,347.
b Less: rental expenses ~ 6b 600,065.
c Rental income or (loss) 6c 767,282.
d Net rental income or (loss)••••••••••••••••• 767,282. 767,282.
7 a Gross amount from sales of (i) Securities (ii) Other
assets other than inventory 7a 7713291379. 14,684,314.
b Less: cost or other basis
7b 7378552342. 18,808,874.
Other Revenue
and sales expenses ~~~

c Gain or (loss) ~~~~~ 7c 334,739,037. -4,124,560.
d Net gain or (loss) ••••••••••••••••••••• 330,614,477. 330,614,477.
8 a Gross income from fundraising events (not
including $ of
contributions reported on line 1c). See
Part IV, line 18 ~~~~~~~~~~~~ 8a
b Less: direct expenses ~~~~~~~~ 8b
c Net income or (loss) from fundraising events •••••••
9 a Gross income from gaming activities. See
Part IV, line 19 ~~~~~~~~~~~~ 9a
b Less: direct expenses ~~~~~~~~ 9b
c Net income or (loss) from gaming activities ••••••••
10 a Gross sales of inventory, less returns
and allowances ~~~~~~~~~~~~ 10a 347,813.
b Less: cost of goods sold ~~~~~~~ 10b 277,783.
c Net income or (loss) from sales of inventory •••••••• 70,030. 70,030.
Business Code
Miscellaneous
11 a MISC. CONSULTING 541610 10,413,998. 1,781,089. 7,355,576. 1,277,333.

Revenue
b MISC. REVENUE 900099 7,110,562. 4,787,333. 0. 2,323,229.

c CAFETERIA/VENDING 722310 5,466,006. 5,466,006.
d All other revenue ~~~~~~~~~~~~~ 812930 5,194,964. 673,728. 4,521,236.
e Total. Add lines 11a-11d ••••••••••••••••• 28,185,530.
12 Total revenue. See instructions ••••••••••••••• 7,075,354,210. 3,191,523,521. 916,217,531. 577,888,270.
232009 12-13-22 Form 990 (2022)
13
Part IX Statement of Functional Expenses
Section 501(c)(3) and 501(c)(4) organizations must complete all columns. All other organizations must complete column (A).
Check if Schedule O contains a response or note to any line in this Part IX •••••••••••••••••••••••••• X
Do not include amounts reported on lines 6b, (A) (B) (C) (D)
7b, 8b, 9b, and 10b of Part VIII. Total expenses Program service Management and Fundraising
expenses general expenses expenses
1 Grants and other assistance to domestic organizations
and domestic governments. See Part IV, line 21 ~ 292,818,127. 292,818,127.
2 Grants and other assistance to domestic
individuals. See Part IV, line 22 ~~~~~~~ 28,497,500. 28,497,500.
3 Grants and other assistance to foreign
organizations, foreign governments, and foreign
individuals. See Part IV, lines 15 and 16 ~~~ 2,250,787. 2,250,787.
4 Benefits paid to or for members ~~~~~~~
5 Compensation of current officers, directors,
trustees, and key employees ~~~~~~~~ 21,062,793. 19,554,258. 287,913. 1,220,622.
6 Compensation not included above to disqualified
persons (as defined under section 4958(f)(1)) and
persons described in section 4958(c)(3)(B) ~~~ 11,849,805. 11,583,053. 175,406. 91,346.
7 Other salaries and wages ~~~~~~~~~~ 2,524,736,654. 2,400,953,196. 100,273,034. 23,510,424.
8 Pension plan accruals and contributions (include
section 401(k) and 403(b) employer contributions) 71,539,288. 57,379,979. 11,472,593. 2,686,716.
9 Other employee benefits ~~~~~~~~~~ 295,220,414. 274,123,604. 17,778,228. 3,318,582.
10 Payroll taxes ~~~~~~~~~~~~~~~~ 162,670,121. 153,828,464. 7,125,790. 1,715,867.
11 Fees for services (nonemployees):
a Management ~~~~~~~~~~~~~~~~
b Legal ~~~~~~~~~~~~~~~~~~~~ 1,328,691. 744,236. 193,259. 391,196.
c Accounting ~~~~~~~~~~~~~~~~~ 2,528,829. 2,528,829.
d Lobbying ~~~~~~~~~~~~~~~~~~ 313,085. 313,085.
e Professional fundraising services. See Part IV, line 17 902,800. 902,800.
f Investment management fees ~~~~~~~~ 4,704,347. 4,704,347.
g Other. (If line 11g amount exceeds 10% of line 25,
column (A), amount, list line 11g expenses on Sch O.) 866,418,809. 837,752,541. 15,000,741. 13,665,527.
12 Advertising and promotion ~~~~~~~~~ 17,664,227. 17,495,215. 66,742. 102,270.
13 Office expenses~~~~~~~~~~~~~~~ 234,871,105. 216,829,100. 17,018,225. 1,023,780.
14 Information technology ~~~~~~~~~~~ 54,365,662. 53,055,270. 1,293,566. 16,826.
15 Royalties ~~~~~~~~~~~~~~~~~~ 4,322,175. 4,319,675. 2,500.
16 Occupancy ~~~~~~~~~~~~~~~~~ 67,747,300. 36,814,200. 29,475,664. 1,457,436.
17 Travel ~~~~~~~~~~~~~~~~~~~ 48,763,461. 46,346,116. 1,443,075. 974,270.
18 Payments of travel or entertainment expenses
for any federal, state, or local public officials ~
19 Conferences, conventions, and meetings ~~ 4,719,011. 4,636,877. 73,647. 8,487.
20 Interest ~~~~~~~~~~~~~~~~~~ 133,230,969. 80,189,416. 53,041,553.
21 Payments to affiliates ~~~~~~~~~~~~
22 Depreciation, depletion, and amortization ~~ 188,378,789. 186,333,436. 1,975,893. 69,460.
23 Insurance ~~~~~~~~~~~~~~~~~ 25,529,406. 25,529,406.
24 Other expenses. Itemize expenses not covered
above. (List miscellaneous expenses on line 24e. If
line 24e amount exceeds 10% of line 25, column (A),
amount, list line 24e expenses on Schedule O.)
a MEDICAL SUPPLIES 473,293,285. 473,293,285.
b UBIT 20,273,267. 20,273,215. 52.
c EMPLOYEE RELATED 40,245,561. 37,267,122. 2,918,976. 59,463.
d MN CARE TAX 39,909,938. 39,908,563. 1,375.
e All other expenses 37,799,420. 35,886,018. 1,890,422. 22,980.
25 Total functional expenses. Add lines 1 through 24e 5,677,955,626. 5,357,975,744. 268,741,830. 51,238,052.
26 Joint costs. Complete this line only if the organization
reported in column (B) joint costs from a combined
educational campaign and fundraising solicitation.
Check here if following SOP 98-2 (ASC 958-720)
232010 12-13-22 Form 990 (2022)

14
Part X Balance Sheet
Check if Schedule O contains a response or note to any line in this Part X •••••••••••••••••••••••••••••
(A) (B)
Beginning of year End of year
1 Cash - non-interest-bearing ~~~~~~~~~~~~~~~~~~~~~~~~~ 1,715,225. 1 7,612,763.
2 Savings and temporary cash investments ~~~~~~~~~~~~~~~~~~ 88,122. 2 1,296,847,969.
3 Pledges and grants receivable, net ~~~~~~~~~~~~~~~~~~~~~ 496,652,443. 3 552,606,481.
4 Accounts receivable, net ~~~~~~~~~~~~~~~~~~~~~~~~~~ 550,987,625. 4 512,569,768.
5 Loans and other receivables from any current or former officer, director,
trustee, key employee, creator or founder, substantial contributor, or 35%
controlled entity or family member of any of these persons ~~~~~~~~~ 5
6 Loans and other receivables from other disqualified persons (as defined
under section 4958(f)(1)), and persons described in section 4958(c)(3)(B) ~~ 6
7 Notes and loans receivable, net ~~~~~~~~~~~~~~~~~~~~~~~ 2,101,222. 7 1,850,548.
Assets
8 Inventories for sale or use ~~~~~~~~~~~~~~~~~~~~~~~~~~ 9,188,537. 8 10,787,335.

9 Prepaid expenses and deferred charges ~~~~~~~~~~~~~~~~~~ 40,641,706. 9 55,435,863.
10 a Land, buildings, and equipment: cost or other
basis. Complete Part VI of Schedule D ~~~ 10a 3,994,895,209.
b Less: accumulated depreciation ~~~~~~ 10b 2,481,922,966. 1,467,091,871. 10c 1,512,972,243.
11 Investments - publicly traded securities ~~~~~~~~~~~~~~~~~~~ 577,599,401. 11 509,632,934.
12 Investments - other securities. See Part IV, line 11 ~~~~~~~~~~~~~~ 14,825,293,684. 12 16,069,269,429.
13 Investments - program-related. See Part IV, line 11 ~~~~~~~~~~~~~ 13
14 Intangible assets ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 14
15 Other assets. See Part IV, line 11 ~~~~~~~~~~~~~~~~~~~~~~ 2,572,442,526. 15 1,578,054,092.
16 Total assets. Add lines 1 through 15 (must equal line 33) •••••••••• 20,543,802,362. 16 22,107,639,425.
17 Accounts payable and accrued expenses ~~~~~~~~~~~~~~~~~~ 2,627,802,035. 17 2,064,798,992.
18 Grants payable ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 18
19 Deferred revenue ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 111,583,445. 19 172,598,176.
20 Tax-exempt bond liabilities ~~~~~~~~~~~~~~~~~~~~~~~~~ 1,406,307,809. 20 1,474,194,291.
21 Escrow or custodial account liability. Complete Part IV of Schedule D ~~~~ 21
22 Loans and other payables to any current or former officer, director,
Liabilities
trustee, key employee, creator or founder, substantial contributor, or 35%

controlled entity or family member of any of these persons ~~~~~~~~~ 22
23 Secured mortgages and notes payable to unrelated third parties ~~~~~~ 2,493,906,542. 23 2,691,172,955.
24 Unsecured notes and loans payable to unrelated third parties ~~~~~~~~ 24
25 Other liabilities (including federal income tax, payables to related third
parties, and other liabilities not included on lines 17-24). Complete Part X
of Schedule D ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3,526,450,006. 25 3,175,406,333.
26 Total liabilities. Add lines 17 through 25 •••••••••••••••••• 10,166,049,837. 26 9,578,170,747.
Organizations that follow FASB ASC 958, check here X
Net Assets or Fund Balances
and complete lines 27, 28, 32, and 33.

27 Net assets without donor restrictions ~~~~~~~~~~~~~~~~~~~~ 5,989,293,754. 27 8,306,935,513.
28 Net assets with donor restrictions ~~~~~~~~~~~~~~~~~~~~~~ 4,388,458,771. 28 4,222,533,165.
Organizations that do not follow FASB ASC 958, check here
and complete lines 29 through 33.
29 Capital stock or trust principal, or current funds ~~~~~~~~~~~~~~~ 29
30 Paid-in or capital surplus, or land, building, or equipment fund ~~~~~~~~ 30
31 Retained earnings, endowment, accumulated income, or other funds ~~~~ 31
32 Total net assets or fund balances ~~~~~~~~~~~~~~~~~~~~~~ 10,377,752,525. 32 12,529,468,678.
33 Total liabilities and net assets/fund balances •••••••••••••••• 20,543,802,362. 33 22,107,639,425.
Form 990 (2022)
232011 12-13-22
15
Part XI Reconciliation of Net Assets
Check if Schedule O contains a response or note to any line in this Part XI •••••••••••••••••••••••••••• X
1 Total revenue (must equal Part VIII, column (A), line 12) ~~~~~~~~~~~~~~~~~~~~~~~~~~ 1 7,075,354,210.
2 Total expenses (must equal Part IX, column (A), line 25) ~~~~~~~~~~~~~~~~~~~~~~~~~~ 2 5,677,955,626.
3 Revenue less expenses. Subtract line 2 from line 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3 1,397,398,584.
4 Net assets or fund balances at beginning of year (must equal Part X, line 32, column (A)) ~~~~~~~~~~ 4 10,377,752,525.
5 Net unrealized gains (losses) on investments ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5 -1,840,274,638.
6 Donated services and use of facilities ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6
7 Investment expenses ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7
8 Prior period adjustments ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 8
9 Other changes in net assets or fund balances (explain on Schedule O) ~~~~~~~~~~~~~~~~~~ 9 2,594,592,207.
10 Net assets or fund balances at end of year. Combine lines 3 through 9 (must equal Part X, line 32,
column (B)) •••••••••••••••••••••••••••••••••••••••••••••••• 10 12,529,468,678.
Part XII Financial Statements and Reporting
Check if Schedule O contains a response or note to any line in this Part XII ••••••••••••••••••••••••••• X
Yes No
1 Accounting method used to prepare the Form 990: Cash X Accrual Other
If the organization changed its method of accounting from a prior year or checked "Other," explain on Schedule O.
2a Were the organization's financial statements compiled or reviewed by an independent accountant? ~~~~~~~~~~~~ 2a X
If "Yes," check a box below to indicate whether the financial statements for the year were compiled or reviewed on a
separate basis, consolidated basis, or both:
Separate basis Consolidated basis Both consolidated and separate basis
b Were the organization's financial statements audited by an independent accountant? ~~~~~~~~~~~~~~~~~~~ 2b X
If "Yes," check a box below to indicate whether the financial statements for the year were audited on a separate basis,
consolidated basis, or both:
Separate basis X Consolidated basis Both consolidated and separate basis
c If "Yes" to line 2a or 2b, does the organization have a committee that assumes responsibility for oversight of the audit,
review, or compilation of its financial statements and selection of an independent accountant?~~~~~~~~~~~~~~~ 2c X
If the organization changed either its oversight process or selection process during the tax year, explain on Schedule O.
3a As a result of a federal award, was the organization required to undergo an audit or audits as set forth in the
Uniform Guidance, 2 C.F.R. Part 200, Subpart F? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3a X
b If "Yes," did the organization undergo the required audit or audits? If the organization did not undergo the required audit
or audits, explain why on Schedule O and describe any steps taken to undergo such audits •••••••••••••••• 3b X
Form 990 (2022)
232012 12-13-22
16
SCHEDULE A OMB No. 1545-0047
Public Charity Status and Public Support

(Form 990)
Complete if the organization is a section 501(c)(3) organization or a section
4947(a)(1) nonexempt charitable trust.
2022
Department of the Treasury Attach to Form 990 or Form 990-EZ. Open to Public
Internal Revenue Service
Go to www.irs.gov/Form990 for instructions and the latest information. Inspection
Name of the organization Employer identification number
MAYO CLINIC 41-6011702
Part I Reason for Public Charity Status. (All organizations must complete this part.) See instructions.
The organization is not a private foundation because it is: (For lines 1 through 12, check only one box.)
1 A church, convention of churches, or association of churches described in section 170(b)(1)(A)(i).
2 A school described in section 170(b)(1)(A)(ii). (Attach Schedule E (Form 990).)
3 A hospital or a cooperative hospital service organization described in section 170(b)(1)(A)(iii).
4 A medical research organization operated in conjunction with a hospital described in section 170(b)(1)(A)(iii). Enter the hospital's name,
city, and state:
5 An organization operated for the benefit of a college or university owned or operated by a governmental unit described in
section 170(b)(1)(A)(iv). (Complete Part II.)
6 A federal, state, or local government or governmental unit described in section 170(b)(1)(A)(v).
7 An organization that normally receives a substantial part of its support from a governmental unit or from the general public described in
section 170(b)(1)(A)(vi). (Complete Part II.)
8 A community trust described in section 170(b)(1)(A)(vi). (Complete Part II.)
9 An agricultural research organization described in section 170(b)(1)(A)(ix) operated in conjunction with a land-grant college
or university or a non-land-grant college of agriculture (see instructions). Enter the name, city, and state of the college or
university:
10 X An organization that normally receives (1) more than 33 1/3% of its support from contributions, membership fees, and gross receipts from
activities related to its exempt functions, subject to certain exceptions; and (2) no more than 33 1/3% of its support from gross investment
income and unrelated business taxable income (less section 511 tax) from businesses acquired by the organization after June 30, 1975.
See section 509(a)(2). (Complete Part III.)
11 An organization organized and operated exclusively to test for public safety. See section 509(a)(4).
12 An organization organized and operated exclusively for the benefit of, to perform the functions of, or to carry out the purposes of one or
more publicly supported organizations described in section 509(a)(1) or section 509(a)(2). See section 509(a)(3). Check the box on
lines 12a through 12d that describes the type of supporting organization and complete lines 12e, 12f, and 12g.
a Type I. A supporting organization operated, supervised, or controlled by its supported organization(s), typically by giving
the supported organization(s) the power to regularly appoint or elect a majority of the directors or trustees of the supporting
organization. You must complete Part IV, Sections A and B.
b Type II. A supporting organization supervised or controlled in connection with its supported organization(s), by having
control or management of the supporting organization vested in the same persons that control or manage the supported
organization(s). You must complete Part IV, Sections A and C.
c Type III functionally integrated. A supporting organization operated in connection with, and functionally integrated with,
its supported organization(s) (see instructions). You must complete Part IV, Sections A, D, and E.
d Type III non-functionally integrated. A supporting organization operated in connection with its supported organization(s)
that is not functionally integrated. The organization generally must satisfy a distribution requirement and an attentiveness
requirement (see instructions). You must complete Part IV, Sections A and D, and Part V.
e Check this box if the organization received a written determination from the IRS that it is a Type I, Type II, Type III
functionally integrated, or Type III non-functionally integrated supporting organization.
f Enter the number of supported organizations ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
g Provide the following information about the supported organization(s).
(i) Name of supported (ii) EIN (iii) Type of organization (iv) Is the organization listed (v) Amount of monetary (vi) Amount of other
in your governing document?
organization (described on lines 1-10 support (see instructions) support (see instructions)
above (see instructions)) Yes No
Total
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ. 232021 12-09-22 Schedule A (Form 990) 2022
Schedule A (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part II Support Schedule for Organizations Described in Sections 170(b)(1)(A)(iv) and 170(b)(1)(A)(vi)
(Complete only if you checked the box on line 5, 7, or 8 of Part I or if the organization failed to qualify under Part III. If the organization
fails to qualify under the tests listed below, please complete Part III.)
Section A. Public Support
Calendar year (or fiscal year beginning in) (a) 2018 (b) 2019 (c) 2020 (d) 2021 (e) 2022 (f) Total
1 Gifts, grants, contributions, and
membership fees received. (Do not
include any "unusual grants.") ~~
2 Tax revenues levied for the organ-
ization's benefit and either paid to
or expended on its behalf ~~~~
3 The value of services or facilities
furnished by a governmental unit to
the organization without charge ~
4 Total. Add lines 1 through 3 ~~~
5 The portion of total contributions
by each person (other than a
governmental unit or publicly
supported organization) included
on line 1 that exceeds 2% of the
amount shown on line 11,
column (f) ~~~~~~~~~~~~
6 Public support. Subtract line 5 from line 4.
Section B. Total Support
7 Amounts from line 4 ~~~~~~~
8 Gross income from interest,
dividends, payments received on
securities loans, rents, royalties,
and income from similar sources ~
9 Net income from unrelated business
activities, whether or not the
business is regularly carried on ~
10 Other income. Do not include gain
or loss from the sale of capital
assets (Explain in Part VI.) ~~~~
11 Total support. Add lines 7 through 10
12 Gross receipts from related activities, etc. (see instructions) ~~~~~~~~~~~~~~~~~~~~~~~ 12
13 First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3)
organization, check this box and stop here •••••••••••••••••••••••••••••••••••••••••••••••
Section C. Computation of Public Support Percentage
14 Public support percentage for 2022 (line 6, column (f), divided by line 11, column (f)) ~~~~~~~~~~~ 14 %
15 Public support percentage from 2021 Schedule A, Part II, line 14 ~~~~~~~~~~~~~~~~~~~~~ 15 %
16a 33 1/3% support test - 2022. If the organization did not check the box on line 13, and line 14 is 33 1/3% or more, check this box and
stop here. The organization qualifies as a publicly supported organization ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
b 33 1/3% support test - 2021. If the organization did not check a box on line 13 or 16a, and line 15 is 33 1/3% or more, check this box
and stop here. The organization qualifies as a publicly supported organization ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
17a 10% -facts-and-circumstances test - 2022. If the organization did not check a box on line 13, 16a, or 16b, and line 14 is 10% or more,
and if the organization meets the facts-and-circumstances test, check this box and stop here. Explain in Part VI how the organization
meets the facts-and-circumstances test. The organization qualifies as a publicly supported organization ~~~~~~~~~~~~~~~~~
b 10% -facts-and-circumstances test - 2021. If the organization did not check a box on line 13, 16a, 16b, or 17a, and line 15 is 10% or
more, and if the organization meets the facts-and-circumstances test, check this box and stop here. Explain in Part VI how the
organization meets the facts-and-circumstances test. The organization qualifies as a publicly supported organization ~~~~~~~~~~~
18 Private foundation. If the organization did not check a box on line 13, 16a, 16b, 17a, or 17b, check this box and see instructions •••••
Schedule A (Form 990) 2022
232022 12-09-22
18
Part III Support Schedule for Organizations Described in Section 509(a)(2)
(Complete only if you checked the box on line 10 of Part I or if the organization failed to qualify under Part II. If the organization fails to
qualify under the tests listed below, please complete Part II.)
Section A. Public Support
1 Gifts, grants, contributions, and
membership fees received. (Do not
include any "unusual grants.") ~~ 1975507156. 2194234892. 2422520612. 2825326266. 2389724888. 11807313814.
2 Gross receipts from admissions,
merchandise sold or services per-
formed, or facilities furnished in
any activity that is related to the
organization's tax-exempt purpose 3390245417. 3324127662. 3408043003. 3197736676. 3191523521. 16511676279.
3 Gross receipts from activities that
are not an unrelated trade or bus-
iness under section 513 ~~~~~ 17,480,366. 17,097,585. 9,994,115. 12,809,372. 8,121,798. 65,503,236.
4 Tax revenues levied for the organ-
ization's benefit and either paid to
or expended on its behalf ~~~~
5 The value of services or facilities
furnished by a governmental unit to
the organization without charge ~
6 Total. Add lines 1 through 5 ~~~ 5383232939. 5535460139. 5840557730. 6035872314. 5589370207. 28384493329.
7 a Amounts included on lines 1, 2, and
3 received from disqualified persons 0.
b Amounts included on lines 2 and 3 received
from other than disqualified persons that
exceed the greater of $5,000 or 1% of the
amount on line 13 for the year ~~~~~~ 0.
c Add lines 7a and 7b ~~~~~~~ 0.
8 Public support. (Subtract line 7c from line 6.) 28384493329.
Section B. Total Support
9 Amounts from line 6 ~~~~~~~ 5383232939. 5535460139. 5840557730. 6035872314. 5589370207. 28384493329.
10a Gross income from interest,
dividends, payments received on
securities loans, rents, royalties,
and income from similar sources ~ 54,704,231. 230,253,855. 200,743,329. 271,179,894. 239,752,060. 996,633,369.
b Unrelated business taxable income
(less section 511 taxes) from businesses
acquired after June 30, 1975 ~~~~ 78,762,106. 114,491,776. 180,609,096. 160,531,494. 118,746,266. 653,140,738.
c Add lines 10a and 10b ~~~~~~ 133,466,337. 344,745,631. 381,352,425. 431,711,388. 358,498,326. 1649774107.
11 Net income from unrelated business
activities not included on line 10b,
whether or not the business is
regularly carried on ~~~~~~~
12 Other income. Do not include gain
or loss from the sale of capital 5,805,837. 5,805,837.
assets (Explain in Part VI.) ~~~~
13 Total support. (Add lines 9, 10c, 11, and 12.) 5522505113. 5880205770. 6221910155. 6467583702. 5947868533. 30040073273.
14 First 5 years. If the Form 990 is for the organization's first, second, third, fourth, or fifth tax year as a section 501(c)(3) organization,
check this box and stop here ••••••••••••••••••••••••••••••••••••••••••••••••••••••
Section C. Computation of Public Support Percentage
15 Public support percentage for 2022 (line 8, column (f), divided by line 13, column (f)) ~~~~~~~~~~~ 15 94.49 %
16 Public support percentage from 2021 Schedule A, Part III, line 15 •••••••••••••••••••• 16 94.97 %
Section D. Computation of Investment Income Percentage
17 Investment income percentage for 2022 (line 10c, column (f), divided by line 13, column (f)) ~~~~~~~~ 17 5.49 %
18 Investment income percentage from 2021 Schedule A, Part III, line 17 ~~~~~~~~~~~~~~~~~~ 18 4.97 %
19 a 33 1/3% support tests - 2022. If the organization did not check the box on line 14, and line 15 is more than 33 1/3%, and line 17 is not
more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ~~~~~~~~~~~~ X
b 33 1/3% support tests - 2021. If the organization did not check a box on line 14 or line 19a, and line 16 is more than 33 1/3%, and
line 18 is not more than 33 1/3%, check this box and stop here. The organization qualifies as a publicly supported organization ~~~~~~
20 Private foundation. If the organization did not check a box on line 14, 19a, or 19b, check this box and see instructions ••••••••••
232023 12-09-22 Schedule A (Form 990) 2022
19
Part IV Supporting Organizations
(Complete only if you checked a box on line 12 of Part I. If you checked box 12a, Part I, complete Sections A
and B. If you checked box 12b, Part I, complete Sections A and C. If you checked box 12c, Part I, complete
Sections A, D, and E. If you checked box 12d, Part I, complete Sections A and D, and complete Part V.)
Section A. All Supporting Organizations
Yes No
1 Are all of the organization's supported organizations listed by name in the organization's governing
documents? If "No," describe in Part VI how the supported organizations are designated. If designated by
class or purpose, describe the designation. If historic and continuing relationship, explain. 1
2 Did the organization have any supported organization that does not have an IRS determination of status
under section 509(a)(1) or (2)? If "Yes," explain in Part VI how the organization determined that the supported
organization was described in section 509(a)(1) or (2). 2
3a Did the organization have a supported organization described in section 501(c)(4), (5), or (6)? If "Yes," answer
lines 3b and 3c below. 3a
b Did the organization confirm that each supported organization qualified under section 501(c)(4), (5), or (6) and
satisfied the public support tests under section 509(a)(2)? If "Yes," describe in Part VI when and how the
organization made the determination. 3b
c Did the organization ensure that all support to such organizations was used exclusively for section 170(c)(2)(B)
purposes? If "Yes," explain in Part VI what controls the organization put in place to ensure such use. 3c
4a Was any supported organization not organized in the United States ("foreign supported organization")? If
"Yes," and if you checked box 12a or 12b in Part I, answer lines 4b and 4c below. 4a
b Did the organization have ultimate control and discretion in deciding whether to make grants to the foreign
supported organization? If "Yes," describe in Part VI how the organization had such control and discretion
despite being controlled or supervised by or in connection with its supported organizations. 4b
c Did the organization support any foreign supported organization that does not have an IRS determination
under sections 501(c)(3) and 509(a)(1) or (2)? If "Yes," explain in Part VI what controls the organization used
to ensure that all support to the foreign supported organization was used exclusively for section 170(c)(2)(B)
purposes. 4c
5a Did the organization add, substitute, or remove any supported organizations during the tax year? If "Yes,"
answer lines 5b and 5c below (if applicable). Also, provide detail in Part VI, including (i) the names and EIN
numbers of the supported organizations added, substituted, or removed; (ii) the reasons for each such action;
(iii) the authority under the organization's organizing document authorizing such action; and (iv) how the action
was accomplished (such as by amendment to the organizing document). 5a
b Type I or Type II only. Was any added or substituted supported organization part of a class already
designated in the organization's organizing document? 5b
c Substitutions only. Was the substitution the result of an event beyond the organization's control? 5c
6 Did the organization provide support (whether in the form of grants or the provision of services or facilities) to
anyone other than (i) its supported organizations, (ii) individuals that are part of the charitable class
benefited by one or more of its supported organizations, or (iii) other supporting organizations that also
support or benefit one or more of the filing organization's supported organizations? If "Yes," provide detail in
Part VI. 6
7 Did the organization provide a grant, loan, compensation, or other similar payment to a substantial contributor
(as defined in section 4958(c)(3)(C)), a family member of a substantial contributor, or a 35% controlled entity with
regard to a substantial contributor? If "Yes," complete Part I of Schedule L (Form 990). 7
8 Did the organization make a loan to a disqualified person (as defined in section 4958) not described on line 7?
If "Yes," complete Part I of Schedule L (Form 990). 8
9a Was the organization controlled directly or indirectly at any time during the tax year by one or more
disqualified persons, as defined in section 4946 (other than foundation managers and organizations described
in section 509(a)(1) or (2))? If "Yes," provide detail in Part VI. 9a
b Did one or more disqualified persons (as defined on line 9a) hold a controlling interest in any entity in which
the supporting organization had an interest? If "Yes," provide detail in Part VI. 9b
c Did a disqualified person (as defined on line 9a) have an ownership interest in, or derive any personal benefit
from, assets in which the supporting organization also had an interest? If "Yes," provide detail in Part VI. 9c
10a Was the organization subject to the excess business holdings rules of section 4943 because of section
4943(f) (regarding certain Type II supporting organizations, and all Type III non-functionally integrated
supporting organizations)? If "Yes," answer line 10b below. 10a
b Did the organization have any excess business holdings in the tax year? (Use Schedule C, Form 4720, to
determine whether the organization had excess business holdings.) 10b
232024 12-09-22 Schedule A (Form 990) 2022
20
Part IV Supporting Organizations (continued)
Yes No
11 Has the organization accepted a gift or contribution from any of the following persons?
a A person who directly or indirectly controls, either alone or together with persons described on lines 11b and
11c below, the governing body of a supported organization? 11a
b A family member of a person described on line 11a above? 11b
c A 35% controlled entity of a person described on line 11a or 11b above? If "Yes" to line 11a, 11b, or 11c, provide
detail in Part VI. 11c
Section B. Type I Supporting Organizations
Yes No
1 Did the governing body, members of the governing body, officers acting in their official capacity, or membership of one or
more supported organizations have the power to regularly appoint or elect at least a majority of the organization's officers,
directors, or trustees at all times during the tax year? If "No," describe in Part VI how the supported organization(s)
effectively operated, supervised, or controlled the organization's activities. If the organization had more than one supported
organization, describe how the powers to appoint and/or remove officers, directors, or trustees were allocated among the
supported organizations and what conditions or restrictions, if any, applied to such powers during the tax year. 1
2 Did the organization operate for the benefit of any supported organization other than the supported
organization(s) that operated, supervised, or controlled the supporting organization? If "Yes," explain in
Part VI how providing such benefit carried out the purposes of the supported organization(s) that operated,
supervised, or controlled the supporting organization. 2
Section C. Type II Supporting Organizations
Yes No
1 Were a majority of the organization's directors or trustees during the tax year also a majority of the directors
or trustees of each of the organization's supported organization(s)? If "No," describe in Part VI how control
or management of the supporting organization was vested in the same persons that controlled or managed
the supported organization(s). 1
Section D. All Type III Supporting Organizations
Yes No
1 Did the organization provide to each of its supported organizations, by the last day of the fifth month of the
organization's tax year, (i) a written notice describing the type and amount of support provided during the prior tax
year, (ii) a copy of the Form 990 that was most recently filed as of the date of notification, and (iii) copies of the
organization's governing documents in effect on the date of notification, to the extent not previously provided? 1
2 Were any of the organization's officers, directors, or trustees either (i) appointed or elected by the supported
organization(s) or (ii) serving on the governing body of a supported organization? If "No," explain in Part VI how
the organization maintained a close and continuous working relationship with the supported organization(s). 2
3 By reason of the relationship described on line 2, above, did the organization's supported organizations have a
significant voice in the organization's investment policies and in directing the use of the organization's
income or assets at all times during the tax year? If "Yes," describe in Part VI the role the organization's
supported organizations played in this regard. 3
Section E. Type III Functionally Integrated Supporting Organizations
1 Check the box next to the method that the organization used to satisfy the Integral Part Test during the year(see instructions).
a The organization satisfied the Activities Test. Complete line 2 below.
b The organization is the parent of each of its supported organizations. Complete line 3 below.
c The organization supported a governmental entity. Describe in Part VI how you supported a governmental entity (see instructions).
2 Activities Test. Answer lines 2a and 2b below. Yes No
a Did substantially all of the organization's activities during the tax year directly further the exempt purposes of
the supported organization(s) to which the organization was responsive? If "Yes," then in Part VI identify
those supported organizations and explain how these activities directly furthered their exempt purposes,
how the organization was responsive to those supported organizations, and how the organization determined
that these activities constituted substantially all of its activities. 2a
b Did the activities described on line 2a, above, constitute activities that, but for the organization's involvement,
one or more of the organization's supported organization(s) would have been engaged in? If "Yes," explain in
Part VI the reasons for the organization's position that its supported organization(s) would have engaged in
these activities but for the organization's involvement. 2b
3 Parent of Supported Organizations. Answer lines 3a and 3b below.
a Did the organization have the power to regularly appoint or elect a majority of the officers, directors, or
trustees of each of the supported organizations? If "Yes" or "No" provide details in Part VI. 3a
b Did the organization exercise a substantial degree of direction over the policies, programs, and activities of each
of its supported organizations? If "Yes," describe in Part VI the role played by the organization in this regard. 3b
232025 12-09-22 Schedule A (Form 990) 2022
21
Part V Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations
1 Check here if the organization satisfied the Integral Part Test as a qualifying trust on Nov. 20, 1970 (explain in Part VI). See instructions.
All other Type III non-functionally integrated supporting organizations must complete Sections A through E.
(B) Current Year
Section A - Adjusted Net Income (A) Prior Year (optional)
1 Net short-term capital gain 1
2 Recoveries of prior-year distributions 2
3 Other gross income (see instructions) 3
4 Add lines 1 through 3. 4
5 Depreciation and depletion 5
6 Portion of operating expenses paid or incurred for production or
collection of gross income or for management, conservation, or
maintenance of property held for production of income (see instructions) 6
7 Other expenses (see instructions) 7
8 Adjusted Net Income (subtract lines 5, 6, and 7 from line 4) 8
(B) Current Year
Section B - Minimum Asset Amount (A) Prior Year (optional)
1 Aggregate fair market value of all non-exempt-use assets (see
instructions for short tax year or assets held for part of year):
a Average monthly value of securities 1a
b Average monthly cash balances 1b
c Fair market value of other non-exempt-use assets 1c
d Total (add lines 1a, 1b, and 1c) 1d
e Discount claimed for blockage or other factors
(explain in detail in Part VI):
2 Acquisition indebtedness applicable to non-exempt-use assets 2
3 Subtract line 2 from line 1d. 3
4 Cash deemed held for exempt use. Enter 0.015 of line 3 (for greater amount,
see instructions). 4
5 Net value of non-exempt-use assets (subtract line 4 from line 3) 5
6 Multiply line 5 by 0.035. 6
7 Recoveries of prior-year distributions 7
8 Minimum Asset Amount (add line 7 to line 6) 8
Section C - Distributable Amount Current Year
1 Adjusted net income for prior year (from Section A, line 8, column A) 1
2 Enter 0.85 of line 1. 2
3 Minimum asset amount for prior year (from Section B, line 8, column A) 3
4 Enter greater of line 2 or line 3. 4
5 Income tax imposed in prior year 5
6 Distributable Amount. Subtract line 5 from line 4, unless subject to
emergency temporary reduction (see instructions). 6
7 Check here if the current year is the organization's first as a non-functionally integrated Type III supporting organization (see
instructions).
232026 12-09-22
22
Part V Type III Non-Functionally Integrated 509(a)(3) Supporting Organizations (continued)
Section D - Distributions Current Year
1 Amounts paid to supported organizations to accomplish exempt purposes 1
2 Amounts paid to perform activity that directly furthers exempt purposes of supported
organizations, in excess of income from activity 2
3 Administrative expenses paid to accomplish exempt purposes of supported organizations 3
4 Amounts paid to acquire exempt-use assets 4
5 Qualified set-aside amounts (prior IRS approval required - provide details in Part VI) 5
6 Other distributions (describe in Part VI). See instructions. 6
7 Total annual distributions. Add lines 1 through 6. 7
8 Distributions to attentive supported organizations to which the organization is responsive
(provide details in Part VI). See instructions. 8
9 Distributable amount for 2022 from Section C, line 6 9
10 Line 8 amount divided by line 9 amount 10
(i) (ii) (iii)
Section E - Distribution Allocations (see instructions) Excess Distributions Underdistributions Distributable
Pre-2022 Amount for 2022
1 Distributable amount for 2022 from Section C, line 6

2 Underdistributions, if any, for years prior to 2022 (reason-
able cause required - explain in Part VI). See instructions.
3 Excess distributions carryover, if any, to 2022
a From 2017
b From 2018
c From 2019
d From 2020
e From 2021
f Total of lines 3a through 3e
g Applied to underdistributions of prior years
h Applied to 2022 distributable amount
i Carryover from 2017 not applied (see instructions)
j Remainder. Subtract lines 3g, 3h, and 3i from line 3f.
4 Distributions for 2022 from Section D,
line 7: $
a Applied to underdistributions of prior years
b Applied to 2022 distributable amount
c Remainder. Subtract lines 4a and 4b from line 4.
5 Remaining underdistributions for years prior to 2022, if
any. Subtract lines 3g and 4a from line 2. For result greater
than zero, explain in Part VI. See instructions.
6 Remaining underdistributions for 2022. Subtract lines 3h
and 4b from line 1. For result greater than zero, explain in
Part VI. See instructions.
7 Excess distributions carryover to 2023. Add lines 3j
and 4c.
8 Breakdown of line 7:
a Excess from 2018
b Excess from 2019
c Excess from 2020
d Excess from 2021
e Excess from 2022
232027 12-09-22
23
Part VI Supplemental Information. Provide the explanations required by Part II, line 10; Part II, line 17a or 17b; Part III, line 12;
Part IV, Section A, lines 1, 2, 3b, 3c, 4b, 4c, 5a, 6, 9a, 9b, 9c, 11a, 11b, and 11c; Part IV, Section B, lines 1 and 2; Part IV, Section C,
line 1; Part IV, Section D, lines 2 and 3; Part IV, Section E, lines 1c, 2a, 2b, 3a, and 3b; Part V, line 1; Part V, Section B, line 1e; Part V,
Section D, lines 5, 6, and 8; and Part V, Section E, lines 2, 5, and 6. Also complete this part for any additional information.
(See instructions.)
SCHEDULE A, PART III, LINE 12, EXPLANATION FOR OTHER INCOME:
MISCELLANEOUS
2018 AMOUNT: $ 5,805,837.
SCHEDULE A PART I LINE 2:
WHILE THE IRS DETERMINED THAT MAYO CLINIC QUALIFIES UNDER LINE 10, AN
ORGANIZATION THAT NORMALLY RECEIVES: (1) MORE THAN 33 1/3% OF ITS
SUPPORT FROM CONTRIBUTIONS, MEMBERSHIP FEES, AND GROSS RECEIPTS FROM
ACTIVITIES RELATED TO ITS EXEMPT FUNCTIONS, AND (2) NO MORE THAN 33
1/3% OF ITS SUPPORT FROM GROSS INVESTMENT INCOME AND UNRELATED BUSINESS
TAXABLE INCOME, WE BELIEVE THAT IT ALSO QUALIFIES UNDER THE
CLASSIFICATION OF LINE 2 - A SCHOOL DESCRIBED IN SECTION
170(B)(1)(A)(II), LINE 3 - A HOSPITAL OR A COOPERATIVE HOSPITAL SERVICE
ORGANIZATION DESCRIBED IN SECTION 170(B)(1)(A)(III), AND LINE 7, AN
ORGANIZATION THAT NORMALLY RECEIVES A SUBSTANTIAL PART OF ITS SUPPORT
FROM A GOVERNMENTAL UNIT OR FROM THE GENERAL PUBLIC DESCRIBED IN
SECTION 170(B)(1)(A)(VI).
232028 12-09-22 Schedule A (Form 990) 2022

24
** PUBLIC DISCLOSURE COPY **
Schedule B Schedule of Contributors OMB No. 1545-0047
2022
(Form 990) Attach to Form 990 or Form 990-PF.
Department of the Treasury
Go to www.irs.gov/Form990 for the latest information.

Organization type (check one):
Filers of: Section:
Form 990 or 990-EZ X 501(c)( 3 ) (enter number) organization
4947(a)(1) nonexempt charitable trust not treated as a private foundation
527 political organization
Form 990-PF 501(c)(3) exempt private foundation
4947(a)(1) nonexempt charitable trust treated as a private foundation
501(c)(3) taxable private foundation
Check if your organization is covered by the General Rule or a Special Rule.

Note: Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See instructions.
General Rule
For an organization filing Form 990, 990-EZ, or 990-PF that received, during the year, contributions totaling $5,000 or more (in money or
property) from any one contributor. Complete Parts I and II. See instructions for determining a contributor's total contributions.
Special Rules
X For an organization described in section 501(c)(3) filing Form 990 or 990-EZ that met the 33 1/3% support test of the regulations under
sections 509(a)(1) and 170(b)(1)(A)(vi), that checked Schedule A (Form 990), Part II, line 13, 16a, or 16b, and that received from any one
contributor, during the year, total contributions of the greater of (1) $5,000; or (2) 2% of the amount on (i) Form 990, Part VIII, line 1h;
or (ii) Form 990-EZ, line 1. Complete Parts I and II.
For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one
contributor, during the year, total contributions of more than $1,000 exclusively for religious, charitable, scientific,
literary, or educational purposes, or for the prevention of cruelty to children or animals. Complete Parts I (entering
"N/A" in column (b) instead of the contributor name and address), II, and III.
For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor, during the
year, contributions exclusively for religious, charitable, etc., purposes, but no such contributions totaled more than $1,000. If this box
is checked, enter here the total contributions that were received during the year for an exclusively religious, charitable, etc.,
purpose. Don't complete any of the parts unless the General Rule applies to this organization because it received nonexclusively
religious, charitable, etc., contributions totaling $5,000 or more during the year ~~~~~~~~~~~~~~~~~ $
Caution: An organization that isn't covered by the General Rule and/or the Special Rules doesn't file Schedule B (Form 990), but it must
answer "No" on Part IV, line 2, of its Form 990; or check the box on line H of its Form 990-EZ or on its Form 990-PF, Part I, line 2, to certify
that it doesn't meet the filing requirements of Schedule B (Form 990).
LHA For Paperwork Reduction Act Notice, see the instructions for Form 990, 990-EZ, or 990-PF. Schedule B (Form 990) (2022)
223451 11-15-22
Schedule B (Form 990) (2022) Page 2
Name of organization Employer identification number
Part I Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.
(a) (b) (c) (d)

No. Name, address, and ZIP + 4 Total contributions Type of contribution
1 Person X
Payroll
$ 1,001,213,546. Noncash
(Complete Part II for
noncash contributions.)
(a) (b) (c) (d)

2 Person X
Payroll
$ 301,001,096. Noncash
(a) (b) (c) (d)

3 Person X
Payroll
$ 126,047,125. Noncash
(a) (b) (c) (d)

4 Person X
Payroll
$ 105,579,024. Noncash
(a) (b) (c) (d)

5 Person X
Payroll
$ 100,000,000. Noncash
(a) (b) (c) (d)

6 Person X
Payroll
$ 60,739,754. Noncash
223452 11-15-22 Schedule B (Form 990) (2022)
26
Part II Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.
(a)
(c)
No. (b) (d)
FMV (or estimate)
from Description of noncash property given Date received
(See instructions.)
Part I
(a)
(c)
No. (b) (d)
FMV (or estimate)
(See instructions.)
Part I
(a)
(c)
No. (b) (d)
FMV (or estimate)
(See instructions.)
Part I
(a)
(c)
No. (b) (d)
FMV (or estimate)
(See instructions.)
Part I
(a)
(c)
No. (b) (d)
FMV (or estimate)
(See instructions.)
Part I
(a)
(c)
No. (b) (d)
FMV (or estimate)
(See instructions.)
Part I
$
223453 11-15-22 Schedule B (Form 990) (2022)
27

Part III Exclusively religious, charitable, etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1,000 for the year
from any one contributor. Complete columns (a) through (e) and the following line entry. For organizations
completing Part III, enter the total of exclusively religious, charitable, etc., contributions of $1,000 or less for the year. (Enter this info. once.) $
Use duplicate copies of Part III if additional space is needed.
(a) No.
from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held
Part I
(e) Transfer of gift
Transferee's name, address, and ZIP + 4 Relationship of transferor to transferee
(a) No.
Part I
(a) No.
Part I
(a) No.
Part I
223454 11-15-22 Schedule B (Form 990) (2022)

28
SCHEDULE C Political Campaign and Lobbying Activities OMB No. 1545-0047
(Form 990)
For Organizations Exempt From Income Tax Under section 501(c) and section 527 2022
Complete if the organization is described below. Attach to Form 990 or Form 990-EZ. Open to Public
If the organization answered "Yes," on Form 990, Part IV, line 3, or Form 990-EZ, Part V, line 46 (Political Campaign Activities), then
¥ Section 501(c)(3) organizations: Complete Parts I-A and B. Do not complete Part I-C.
¥ Section 501(c) (other than section 501(c)(3)) organizations: Complete Parts I-A and C below. Do not complete Part I-B.
¥ Section 527 organizations: Complete Part I-A only.
If the organization answered "Yes," on Form 990, Part IV, line 4, or Form 990-EZ, Part VI, line 47 (Lobbying Activities), then
¥ Section 501(c)(3) organizations that have filed Form 5768 (election under section 501(h)): Complete Part II-A. Do not complete Part II-B.
¥ Section 501(c)(3) organizations that have NOT filed Form 5768 (election under section 501(h)): Complete Part II-B. Do not complete Part II-A.
If the organization answered "Yes," on Form 990, Part IV, line 5 (Proxy Tax) (See separate instructions) or Form 990-EZ, Part V, line 35c (Proxy
Tax) (See separate instructions), then
¥ Section 501(c)(4), (5), or (6) organizations: Complete Part III.
Part I-A Complete if the organization is exempt under section 501(c) or is a section 527 organization.
1 Provide a description of the organization's direct and indirect political campaign activities in Part IV.
2 Political campaign activity expenditures ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ $
3 Volunteer hours for political campaign activities ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Part I-B Complete if the organization is exempt under section 501(c)(3).

1 Enter the amount of any excise tax incurred by the organization under section 4955 ~~~~~~~~~~~~~~ $
2 Enter the amount of any excise tax incurred by organization managers under section 4955 ~~~~~~~~~~~ $
3 If the organization incurred a section 4955 tax, did it file Form 4720 for this year? ~~~~~~~~~~~~~~~~~~~ Yes No
4a Was a correction made? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
b If "Yes," describe in Part IV.
Part I-C Complete if the organization is exempt under section 501(c), except section 501(c)(3).
1 Enter the amount directly expended by the filing organization for section 527 exempt function activities ~~~~~ $
2 Enter the amount of the filing organization's funds contributed to other organizations for section 527
exempt function activities ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ $
3 Total exempt function expenditures. Add lines 1 and 2. Enter here and on Form 1120-POL,
line 17b ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ $
4 Did the filing organization file Form 1120-POL for this year? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
5 Enter the names, addresses and employer identification number (EIN) of all section 527 political organizations to which the filing organization
made payments. For each organization listed, enter the amount paid from the filing organization's funds. Also enter the amount of political
contributions received that were promptly and directly delivered to a separate political organization, such as a separate segregated fund or a
political action committee (PAC). If additional space is needed, provide information in Part IV.
(a) Name (b) Address (c) EIN (d) Amount paid from (e) Amount of political
filing organization's contributions received and
funds. If none, enter -0-. promptly and directly
delivered to a separate
political organization.
If none, enter -0-.
For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ. Schedule C (Form 990) 2022
LHA
232041 11-08-22
29
Schedule C (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part II-A Complete if the organization is exempt under section 501(c)(3) and filed Form 5768 (election under
section 501(h)).
A Check if the filing organization belongs to an affiliated group (and list in Part IV each affiliated group member's name, address, EIN,
expenses, and share of excess lobbying expenditures).
B Check if the filing organization checked box A and "limited control" provisions apply.
(a) Filing (b) Affiliated group
Limits on Lobbying Expenditures
organization's totals
(The term "expenditures" means amounts paid or incurred.) totals
1a Total lobbying expenditures to influence public opinion (grassroots lobbying) ~~~~~~~~~~

b Total lobbying expenditures to influence a legislative body (direct lobbying) ~~~~~~~~~~~
c Total lobbying expenditures (add lines 1a and 1b) ~~~~~~~~~~~~~~~~~~~~~~~~
d Other exempt purpose expenditures ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
e Total exempt purpose expenditures (add lines 1c and 1d) ~~~~~~~~~~~~~~~~~~~~
f Lobbying nontaxable amount. Enter the amount from the following table in both columns.
If the amount on line 1e, column (a) or (b) is: The lobbying nontaxable amount is:
Not over $500,000 20% of the amount on line 1e.
Over $500,000 but not over $1,000,000 $100,000 plus 15% of the excess over $500,000.
Over $1,000,000 but not over $1,500,000 $175,000 plus 10% of the excess over $1,000,000.
Over $1,500,000 but not over $17,000,000 $225,000 plus 5% of the excess over $1,500,000.
Over $17,000,000 $1,000,000.
g Grassroots nontaxable amount (enter 25% of line 1f) ~~~~~~~~~~~~~~~~~~~~~~

h Subtract line 1g from line 1a. If zero or less, enter -0- ~~~~~~~~~~~~~~~~~~~~~~
i Subtract line 1f from line 1c. If zero or less, enter -0- ~~~~~~~~~~~~~~~~~~~~~~~
j If there is an amount other than zero on either line 1h or line 1i, did the organization file Form 4720
reporting section 4911 tax for this year? •••••••••••••••••••••••••••••••••••••• Yes No
4-Year Averaging Period Under Section 501(h)
(Some organizations that made a section 501(h) election do not have to complete all of the five columns below.
See the separate instructions for lines 2a through 2f.)
Lobbying Expenditures During 4-Year Averaging Period
Calendar year
(a) 2019 (b) 2020 (c) 2021 (d) 2022 (e) Total
(or fiscal year beginning in)
2 a Lobbying nontaxable amount

b Lobbying ceiling amount
(150% of line 2a, column(e))
c Total lobbying expenditures
d Grassroots nontaxable amount

e Grassroots ceiling amount
(150% of line 2d, column (e))
f Grassroots lobbying expenditures

Schedule C (Form 990) 2022
232042 11-08-22
30
Part II-B Complete if the organization is exempt under section 501(c)(3) and has NOT filed Form 5768
(election under section 501(h)).
For each "Yes" response on lines 1a through 1i below, provide in Part IV a detailed description (a) (b)
of the lobbying activity.
Yes No Amount
1 During the year, did the filing organization attempt to influence foreign, national, state, or
local legislation, including any attempt to influence public opinion on a legislative matter
or referendum, through the use of:
a Volunteers? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X
b Paid staff or management (include compensation in expenses reported on lines 1c through 1i)? ~ X
c Media advertisements? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X
d Mailings to members, legislators, or the public? ~~~~~~~~~~~~~~~~~~~~~~~~~ X
e Publications, or published or broadcast statements? ~~~~~~~~~~~~~~~~~~~~~~ X
f Grants to other organizations for lobbying purposes? ~~~~~~~~~~~~~~~~~~~~~~ X
g Direct contact with legislators, their staffs, government officials, or a legislative body? ~~~~~~ X
h Rallies, demonstrations, seminars, conventions, speeches, lectures, or any similar means? ~~~~ X
i Other activities? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X 313,085.
j Total. Add lines 1c through 1i ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 313,085.
2a Did the activities in line 1 cause the organization to be not described in section 501(c)(3)? ~~~~ X
b If "Yes," enter the amount of any tax incurred under section 4912 ~~~~~~~~~~~~~~~~
c If "Yes," enter the amount of any tax incurred by organization managers under section 4912 ~~~
d If the filing organization incurred a section 4912 tax, did it file Form 4720 for this year? ••••••
Part III-A Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section
501(c)(6).
Yes No
1 Were substantially all (90% or more) dues received nondeductible by members? ~~~~~~~~~~~~~~~~~ 1
2 Did the organization make only in-house lobbying expenditures of $2,000 or less? ~~~~~~~~~~~~~~~~ 2
3 Did the organization agree to carry over lobbying and political campaign activity expenditures from the prior year? 3
Part III-B Complete if the organization is exempt under section 501(c)(4), section 501(c)(5), or section
501(c)(6) and if either (a) BOTH Part III-A, lines 1 and 2, are answered "No" OR (b) Part III-A, line 3, is
answered "Yes."
1 Dues, assessments and similar amounts from members ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1
2 Section 162(e) nondeductible lobbying and political expenditures (do not include amounts of political
expenses for which the section 527(f) tax was paid).
a Current year ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2a
b Carryover from last year ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2b
c Total ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2c
3 Aggregate amount reported in section 6033(e)(1)(A) notices of nondeductible section 162(e) dues ~~~~~~~~ 3
4 If notices were sent and the amount on line 2c exceeds the amount on line 3, what portion of the excess
does the organization agree to carryover to the reasonable estimate of nondeductible lobbying and political
expenditures next year?~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4
5 Taxable amount of lobbying and political expenditures. See instructions ••••••••••••••••••••• 5
Part IV Supplemental Information
Provide the descriptions required for Part I-A, line 1; Part I-B, line 4; Part I-C, line 5; Part II-A (affiliated group list); Part II-A, lines 1 and 2 (See
instructions); and Part II-B, line 1. Also, complete this part for any additional information.
PART II-B, LINE 1, LOBBYING ACTIVITIES:
DURING 2022, MAYO CLINIC (MAYO) OFFICIALS HAD MEETINGS AND CONTACTS
WITH FEDERAL AND STATE GOVERNMENT OFFICIALS, INCLUDING MEMBERS OF
CONGRESS, STATE LEGISLATURES, AND RESPECTIVE EXECUTIVE BRANCH OFFICIALS
TO DISCUSS VARIOUS HEALTH CARE REFORM PROPOSALS AND PROPOSED
LEGISLATION. THESE DISCUSSIONS AND MEETINGS WERE HELD IN ROCHESTER, MN

232043 11-08-22
31
Part IV Supplemental Information (continued)
AS WELL AS WASHINGTON, D.C., ST. PAUL, MN AND OTHER MAYO CLINIC SITE
LOCATIONS. IN ADDITION, MAYO SENT CORRESPONDENCE TO MEMBERS, STAFF AND
OTHER GOVERNMENT OFFICIALS OUTLINING MAYO'S POSITIONS AND
RECOMMENDATIONS ON LEGISLATION AND PROPOSED REGULATIONS.
MAYO PROVIDES INFORMATION OR EXPRESSES ITS CONCERN TO LEGISLATIVE
BODIES AND GOVERNMENT OFFICIALS ON MATTERS DIRECTLY RELATED TO HEALTH,
THE DELIVERY OF HEALTH CARE AND MEDICAL EDUCATION AND/OR RESEARCH. IN
2022, MAYO REPRESENTATIVES HAD SEVERAL MEETINGS WITH MEMBERS OF THE
LEGISLATIVE AND EXECUTIVE BRANCHES OF GOVERNMENT TO DISCUSS ISSUES
RELATING TO PATIENT CARE, EDUCATION AND RESEARCH.
IN ADDITION TO CORRESPONDENCE, MAYO EXPRESSES ITS PERSPECTIVE ON POLICY
ISSUES VIA EDITORIALS AND IN RESPONSES TO MEDIA INQUIRIES.
ON OCCASION, MAYO'S POLICY PERSPECTIVE MAY BE INCLUDED IN THE SPEECH
CONTENT OF MAYO LEADERS.
THE MAJORITY OF EXPENSES RELATED TO LOBBYING ARE INCURRED BY MAYO
FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (MFMER), AN AFFILIATED
SUPPORT ORGANIZATION OF MAYO CLINIC.
IN 2022, THE EXPENSES ASSOCIATED WITH THE ABOVE LOBBYING ACTIVITIES
ON BEHALF OF MAYO CLINIC (THE PARENT ORGANIZATION) WHICH ARE INCLUDED
IN THIS FORM 990 ARE $721,435.
SCHEDULE C PART II-B LINE 1I
THE AMOUNT IN OTHER ACTIVITIES REPRESENTS A PORTION OF PROFESSIONAL DUES

232044 11-08-22
32
ATTRIBUTABLE TO LOBBYING.

232044 11-08-22
33
OMB No. 1545-0047
Supplemental Financial Statements
2022
SCHEDULE D
(Form 990) Complete if the organization answered "Yes" on Form 990,
Part IV, line 6, 7, 8, 9, 10, 11a, 11b, 11c, 11d, 11e, 11f, 12a, or 12b.
Department of the Treasury Attach to Form 990. Open to Public
Part I Organizations Maintaining Donor Advised Funds or Other Similar Funds or Accounts.Complete if the
organization answered "Yes" on Form 990, Part IV, line 6.
(a) Donor advised funds (b) Funds and other accounts
1 Total number at end of year ~~~~~~~~~~~~~~~ 10
2 Aggregate value of contributions to (during year) ~~~~ 4,913,280.
3 Aggregate value of grants from (during year) ~~~~~~ 427,500.
4 Aggregate value at end of year ~~~~~~~~~~~~~ 8,203,456.
5 Did the organization inform all donors and donor advisors in writing that the assets held in donor advised funds
are the organization's property, subject to the organization's exclusive legal control? ~~~~~~~~~~~~~~~~~~ X Yes No
6 Did the organization inform all grantees, donors, and donor advisors in writing that grant funds can be used only
for charitable purposes and not for the benefit of the donor or donor advisor, or for any other purpose conferring
impermissible private benefit? •••••••••••••••••••••••••••••••••••••••••••• X Yes No
Part II Conservation Easements. Complete if the organization answered "Yes" on Form 990, Part IV, line 7.
1 Purpose(s) of conservation easements held by the organization (check all that apply).
Preservation of land for public use (for example, recreation or education) Preservation of a historically important land area
Protection of natural habitat Preservation of a certified historic structure
Preservation of open space
2 Complete lines 2a through 2d if the organization held a qualified conservation contribution in the form of a conservation easement on the last
day of the tax year. Held at the End of the Tax Year
a Total number of conservation easements ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2a
b Total acreage restricted by conservation easements ~~~~~~~~~~~~~~~~~~~~~~~~~~ 2b
c Number of conservation easements on a certified historic structure included in (a) ~~~~~~~~~~~~ 2c
d Number of conservation easements included in (c) acquired after July 25,2006, and not on a
historic structure listed in the National Register ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2d
3 Number of conservation easements modified, transferred, released, extinguished, or terminated by the organization during the tax
year
4 Number of states where property subject to conservation easement is located
5 Does the organization have a written policy regarding the periodic monitoring, inspection, handling of
violations, and enforcement of the conservation easements it holds? ~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
6 Staff and volunteer hours devoted to monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
7 Amount of expenses incurred in monitoring, inspecting, handling of violations, and enforcing conservation easements during the year
8 Does each conservation easement reported on line 2(d) above satisfy the requirements of section 170(h)(4)(B)(i)
and section 170(h)(4)(B)(ii)? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
9 In Part XIII, describe how the organization reports conservation easements in its revenue and expense statement and
balance sheet, and include, if applicable, the text of the footnote to the organization's financial statements that describes the
organization's accounting for conservation easements.
Part III Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 8.
1a If the organization elected, as permitted under FASB ASC 958, not to report in its revenue statement and balance sheet works
of art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public
service, provide in Part XIII the text of the footnote to its financial statements that describes these items.
b If the organization elected, as permitted under FASB ASC 958, to report in its revenue statement and balance sheet works of
art, historical treasures, or other similar assets held for public exhibition, education, or research in furtherance of public service,
provide the following amounts relating to these items:
(i) Revenue included on Form 990, Part VIII, line 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ $
(ii) Assets included in Form 990, Part X ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ $
2 If the organization received or held works of art, historical treasures, or other similar assets for financial gain, provide
the following amounts required to be reported under FASB ASC 958 relating to these items:
a Revenue included on Form 990, Part VIII, line 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ $
b Assets included in Form 990, Part X ••••••••••••••••••••••••••••••••••••• $
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990. Schedule D (Form 990) 2022
232051 09-01-22
34
Schedule D (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part III Organizations Maintaining Collections of Art, Historical Treasures, or Other Similar Assets(continued)
3 Using the organization's acquisition, accession, and other records, check any of the following that make significant use of its
collection items (check all that apply):
a X Public exhibition d Loan or exchange program
b Scholarly research e Other
c Preservation for future generations
4 Provide a description of the organization's collections and explain how they further the organization's exempt purpose in Part XIII.
5 During the year, did the organization solicit or receive donations of art, historical treasures, or other similar assets
to be sold to raise funds rather than to be maintained as part of the organization's collection? •••••••••••• Yes X No
Part IV Escrow and Custodial Arrangements. Complete if the organization answered "Yes" on Form 990, Part IV, line 9, or
reported an amount on Form 990, Part X, line 21.
1a Is the organization an agent, trustee, custodian or other intermediary for contributions or other assets not included
on Form 990, Part X? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
b If "Yes," explain the arrangement in Part XIII and complete the following table:
Amount
c Beginning balance ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1c
d Additions during the year ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1d
e Distributions during the year ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1e
f Ending balance ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1f
2a Did the organization include an amount on Form 990, Part X, line 21, for escrow or custodial account liability? ~~~~~ Yes No
b If "Yes," explain the arrangement in Part XIII. Check here if the explanation has been provided on Part XIII •••••••••••••
Part V Endowment Funds. Complete if the organization answered "Yes" on Form 990, Part IV, line 10.
(a) Current year (b) Prior year (c) Two years back (d) Three years back (e) Four years back
1a Beginning of year balance ~~~~~~~ 6,117,351,716. 5,061,662,985. 4,427,091,907. 3,852,237,495. 3,649,041,615.
b Contributions ~~~~~~~~~~~~~~ 113,233,718. 90,896,164. 171,083,411. 155,829,477. 232,064,809.
c Net investment earnings, gains, and losses -545,428,302. 1,143,091,782. 647,792,722. 461,221,455. 59,629,160.
d Grants or scholarships ~~~~~~~~~
e Other expenditures for facilities
and programs ~~~~~~~~~~~~~ 196,565,988. 178,299,215. 184,305,055. 42,196,520. 88,498,089.
f Administrative expenses ~~~~~~~~
g End of year balance ~~~~~~~~~~ 5,488,591,144. 6,117,351,716. 5,061,662,985. 4,427,091,907. 3,852,237,495.
2 Provide the estimated percentage of the current year end balance (line 1g, column (a)) held as:
a Board designated or quasi-endowment 46.3500 %
b Permanent endowment 32.1200 %
c Term endowment 21.5300 %
The percentages on lines 2a, 2b, and 2c should equal 100%.
3a Are there endowment funds not in the possession of the organization that are held and administered for the
organization by: Yes No
(i) Unrelated organizations ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3a(i) X
(ii) Related organizations ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3a(ii) X
b If "Yes" on line 3a(ii), are the related organizations listed as required on Schedule R? ~~~~~~~~~~~~~~~~~~~~ 3b
4 Describe in Part XIII the intended uses of the organization's endowment funds.
Part VI Land, Buildings, and Equipment.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11a. See Form 990, Part X, line 10.
Description of property (a) Cost or other (b) Cost or other (c) Accumulated (d) Book value
basis (investment) basis (other) depreciation
1a Land ~~~~~~~~~~~~~~~~~~~~ 110,386,995. 110,386,995.
b Buildings ~~~~~~~~~~~~~~~~~~ 1,979,600,985. 1,265,323,083. 714,277,902.
c Leasehold improvements ~~~~~~~~~~ 70,020,467. 45,182,876. 24,837,591.
d Equipment ~~~~~~~~~~~~~~~~~ 1,624,703,551. 1,171,417,007. 453,286,544.
e Other •••••••••••••••••••• 210,183,211. 210,183,211.
Total. Add lines 1a through 1e. (Column (d) must equal Form 990, Part X, column (B), line 10c.) ••••••••••••••• 1,512,972,243.
Schedule D (Form 990) 2022
232052 09-01-22
35
Part VII Investments - Other Securities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11b. See Form 990, Part X, line 12.
(a) Description of security or category (including name of security) (b) Book value (c) Method of valuation: Cost or end-of-year market value
(1) Financial derivatives ~~~~~~~~~~~~~~~
(2) Closely held equity interests ~~~~~~~~~~~
(3) Other
(A) MAYO POOLED INVESTMENTS 13,905,311,661. END-OF-YEAR MARKET VALUE
(B) QUALIFIED PENSION PLAN 2,163,957,768. END-OF-YEAR MARKET VALUE
(C)
(D)
(E)
(F)
(G)
(H)
Total. (Col. (b) must equal Form 990, Part X, col. (B) line 12.) 16,069,269,429.
Part VIII Investments - Program Related.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11c. See Form 990, Part X, line 13.
(a) Description of investment (b) Book value (c) Method of valuation: Cost or end-of-year market value
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Col. (b) must equal Form 990, Part X, col. (B) line 13.)
Part IX Other Assets.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11d. See Form 990, Part X, line 15.
(a) Description (b) Book value
(1) INVESTMENTS IN SUBSIDIARIES 526,491,755.
(2) CONTRIBUTED ASSETS PENDING DISPOSAL 80,828,573.
(3) ART 3,167,394.
(4) TRUSTS 139,320,970.
(5) DEFERRED INCOME TAX ASSET 18,641,137.
(6) OTHER LONG TERM ASSETS 244,224,703.
(7) ASSETS HELD FOR DISSOLUTION 307,505.
(8) TECH BASED VENTURES 38,829,388.
(9) BOND-RELATED TRUSTEE HELD INVEST 44,778,159.
Total. (Column (b) must equal Form 990, Part X, col. (B) line 15.) ••••••••••••••••••••••••••••• 1,578,054,092.
Part X Other Liabilities.
Complete if the organization answered "Yes" on Form 990, Part IV, line 11e or 11f. See Form 990, Part X, line 25.
1. (a) Description of liability (b) Book value
(1) Federal income taxes
(2) DUE TO AFFILIATES 3,175,406,333.
(3)
(4)
(5)
(6)
(7)
(8)
(9)
Total. (Column (b) must equal Form 990, Part X, col. (B) line 25.) ••••••••••••••••••••••••••••• 3,175,406,333.
2. Liability for uncertain tax positions. In Part XIII, provide the text of the footnote to the organization's financial statements that reports the
organization's liability for uncertain tax positions under FASB ASC 740. Check here if the text of the footnote has been provided in Part XIII• X
232053 09-01-22 SEE PART XIII FOR CONTINUATIONS

36
Part XI Reconciliation of Revenue per Audited Financial Statements With Revenue per Return.
Complete if the organization answered "Yes" on Form 990, Part IV, line 12a.
1 Total revenue, gains, and other support per audited financial statements ~~~~~~~~~~~~~~~~~~~ 1
2 Amounts included on line 1 but not on Form 990, Part VIII, line 12:
a Net unrealized gains (losses) on investments ~~~~~~~~~~~~~~~~~~ 2a
b Donated services and use of facilities ~~~~~~~~~~~~~~~~~~~~~~ 2b
c Recoveries of prior year grants ~~~~~~~~~~~~~~~~~~~~~~~~~ 2c
d Other (Describe in Part XIII.) ~~~~~~~~~~~~~~~~~~~~~~~~~~ 2d
e Add lines 2a through 2d ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2e
3 Subtract line 2e from line 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3
4 Amounts included on Form 990, Part VIII, line 12, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b ~~~~~~~~ 4a
b Other (Describe in Part XIII.) ~~~~~~~~~~~~~~~~~~~~~~~~~~ 4b
c Add lines 4a and 4b ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4c
5 Total revenue. Add lines 3 and 4c. (This must equal Form 990, Part I, line 12.) ••••••••••••••••• 5
Part XII Reconciliation of Expenses per Audited Financial Statements With Expenses per Return.
Complete if the organization answered "Yes" on Form 990, Part IV, line 12a.
1 Total expenses and losses per audited financial statements ~~~~~~~~~~~~~~~~~~~~~~~~~~ 1
2 Amounts included on line 1 but not on Form 990, Part IX, line 25:
a Donated services and use of facilities ~~~~~~~~~~~~~~~~~~~~~~ 2a
b Prior year adjustments ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2b
c Other losses ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2c
d Other (Describe in Part XIII.) ~~~~~~~~~~~~~~~~~~~~~~~~~~ 2d
e Add lines 2a through 2d ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2e
3 Subtract line 2e from line 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3
4 Amounts included on Form 990, Part IX, line 25, but not on line 1:
a Investment expenses not included on Form 990, Part VIII, line 7b ~~~~~~~~ 4a
b Other (Describe in Part XIII.) ~~~~~~~~~~~~~~~~~~~~~~~~~~ 4b
c Add lines 4a and 4b ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4c
5 Total expenses. Add lines 3 and 4c. (This must equal Form 990, Part I, line 18.) •••••••••••••••• 5
Part XIII Supplemental Information.
Provide the descriptions required for Part II, lines 3, 5, and 9; Part III, lines 1a and 4; Part IV, lines 1b and 2b; Part V, line 4; Part X, line 2; Part XI,
lines 2d and 4b; and Part XII, lines 2d and 4b. Also complete this part to provide any additional information.
PART III, LINE 1A:
MAYO CLINIC PERIODICALLY RECEIVES WORKS OF ART FROM VARIOUS BENEFACTORS.
THESE ITEMS ARE UNIQUE IN NATURE AND ARE HELD ON DISPLAY FOR THE BENEFIT
AND ENJOYMENT OF MAYO'S PATIENTS. IT IS MAYO'S POLICY TO NEITHER
CAPITALIZE CONTRIBUTED WORKS OF ART, NOR RECORD THE RELATED CONTRIBUTION
REVENUE. IN THE RARE OCCURRENCE THAT MAYO CLINIC COMMISSIONS ART; IT IS
REFLECTED AS AN EXPENSE OR ON THE BALANCE SHEET.
PART III, LINE 4:
MAYO'S FOUNDERS RECOGNIZED THAT CARING FOR THE WHOLE PATIENT EXTENDS
BEYOND TREATING PHYSICAL AILMENTS. SINCE ITS INCEPTION, MAYO HAS USED
ART, ARCHITECTURE AND BEAUTY IN SURROUNDINGS TO ADDRESS THE SPIRITUAL

232054 09-01-22 Schedule D (Form 990) 2022
37
Part XIII Supplemental Information (continued)
ASPECTS OF MEDICAL CARE. BENEFACTOR GIFTS FROM PATIENTS, FRIENDS,
EMPLOYEES OR ALUMNI HELP MAYO SUPPORT THE ACQUISITION OF ART USED TO
HUMANIZE THE MEDICAL ENVIRONMENT AND COMPLEMENT THE BELIEF THAT RESTORING
THE MIND AND SPIRIT IS AN IMPORTANT PART OF MAKING THE BODY WELL. WORKS
OF ART DISPLAYED ACROSS THE MAYO CAMPUS PROVIDE BEAUTY, PRESERVATION OF
HERITAGE AND RESPECT FOR THE DIVERSITY OF PATIENTS, VISITORS AND STAFF.
PART V, LINE 4:
THE ENDOWMENT FUNDS PROVIDE A STABLE FUNDING SOURCE FOR RESEARCH AND
EDUCATION PROGRAMS.
PART X, LINE 2:
PORTION OF INCOME TAX FOOTNOTE FROM MAYO CLINIC CONSOLIDATED AUDITED
FINANCIAL STATEMENTS:
MOST OF THE INCOME RECEIVED BY THE CLINIC AND ITS SUBSIDIARIES IS EXEMPT
FROM TAXATION UNDER SECTION 501(A) OF THE INTERNAL REVENUE CODE. SOME OF
ITS SUBSIDIARIES ARE TAXABLE ENTITIES, AND SOME OF THE INCOME RECEIVED BY
OTHERWISE EXEMPT ENTITIES IS SUBJECT TO TAXATION AS UNRELATED BUSINESS
INCOME. THE CLINIC AND ITS SUBSIDIARIES FILE INCOME TAX RETURNS IN THE
U.S., INCLUDING FEDERAL AND VARIOUS STATE RETURNS, AS WELL AS CERTAIN
FOREIGN JURISDICTIONS. THE STATUTES OF LIMITATIONS FOR TAX YEARS 2018
THROUGH 2020 REMAIN OPEN IN MAJOR U.S. TAXING JURISDICTIONS IN WHICH THE
CLINIC AND SUBSIDIARIES ARE SUBJECT TO TAXATION.
THE INTERNAL REVENUE SERVICE (IRS) PERFORMED AN EXAMINATION OF THE TAX AND
INFORMATION RETURNS OF THE CLINIC AND TWO SUBSIDIARIES AND ULTIMATELY
ASSESSED $12 MILLION IN TAXES FOR YEARS 2003-2012. THE RESULTS OF THIS
232055 09-01-22
38
AUDIT WERE ULTIMATELY LITIGATED IN THE U.S. DISTRICT COURT. ON AUGUST 6,
2019, THE COURT ISSUED A SUMMARY JUDGMENT IN FAVOR OF THE CLINIC. THE IRS
APPEALED THIS DECISION AND ON MAY 13, 2021, THE EIGHT CIRCUIT COURT OF
APPEALS REVERSED THE SUMMARY JUDGMENT AND REMANDED THE CASE TO THE U.S.
DISTRICT COURT FOR TRIAL. THE CASE WAS TRIED IN 2022 AND THE U.S.
DISTRICT COURT ISSUED A JUDGEMENT IN FAVOR OF THE CLINIC ON DECEMBER 9,
2022. NO ADJUSTMENT HAS BEEN MADE TO UNRECOGNIZED TAX BENEFITS AS A
RESULT OF THE RULING DUE TO THE IRS HAVING UNTIL FEBRUARY 2023 TO APPEAL.
THE CLINIC HAS REDUCED THE RESERVE FOR UNCERTAIN TAX POSITIONS BY $2
MILLION, INCLUDING INTEREST AND PENALTIES, DURING THE YEAR ENDED DECEMBER
31, 2022. AS OF DECEMBER 31, 2022 AND 2021, THE RESERVE TOTALED $11
MILLION AND $23 MILLION, RESPECTIVELY. IT IS NOT ANTICIPATED THAT A
SIGNIFICANT CHANGE IN THE RESERVE WILL OCCUR OVER THE NEXT 12 MONTHS.
THE CLINIC'S PRACTICE IS TO RECOGNIZE INTEREST AND/OR PENALTIES RELATED TO
INCOME TAX MATTERS IN INCOME TAX EXPENSE.

232055 09-01-22
39
Schedule D (Form 990) MAYO CLINIC 41-6011702 Page 5
Part IX Other Assets. See Form 990, Part X, line 15.

(a) Description (b) Book value
DUE FROM AFFILIATES 481,464,508.
232441 04-01-22 Schedule D (Form 990)

40
SCHEDULE E Schools OMB No. 1545-0047
(Form 990) Complete if the organization answered "Yes" on Form 990, Part IV, line 13, or
Form 990-EZ, Part VI, line 48.
2022
Internal Revenue Service Go to www.irs.gov/Form990 for the latest information. Inspection
Part I
YES NO
1 Does the organization have a racially nondiscriminatory policy toward students by statement in its charter,
bylaws, other governing instrument, or in a resolution of its governing body? ~~~~~~~~~~~~~~~~~~~~~~~~ 1 X
2 Does the organization include a statement of its racially nondiscriminatory policy toward students in all its brochures,
catalogues, and other written communications with the public dealing with student admissions, programs, and scholarships? 2 X
3 Has the organization publicized its racially nondiscriminatory policy on its primary publicly accessible Internet
homepage at all times during its tax year in a manner reasonably expected to be noticed by visitors to the
homepage, or through newspaper or broadcast media during the period of solicitation for students, or during the
registration period if it has no solicitation program, in a way that makes the policy known to all parts of the general
community it serves? If "Yes," please describe. If "No," please explain. If you need more space, use Part II ~~~~~~~~~ 3 X
THE RACIALLY NONDISCRIMINATORY POLICY OF THE MAYO CLINIC
COLLEGE OF MEDICINE AND SCIENCE, WHICH DRAWS STUDENTS FROM
ACROSS THE UNITED STATES AND AROUND THE WORLD, IS MADE
AVAILABLE IN ALL OF ITS PUBLISHED DOCUMENTS AND WEBSITE TO
ANY INTERESTED APPLICANTS.
4 Does the organization maintain the following?
a Records indicating the racial composition of the student body, faculty, and administrative staff? ~~~~~~~~~~~~~~ 4a X
b Records documenting that scholarships and other financial assistance are awarded on a racially nondiscriminatory basis? ~ 4b X
c Copies of all catalogues, brochures, announcements, and other written communications to the public dealing
with student admissions, programs, and scholarships? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4c X
d Copies of all material used by the organization or on its behalf to solicit contributions? ~~~~~~~~~~~~~~~~~~~ 4d X
If you answered "No" to any of the above, please explain. If you need more space, use Part II.
5 Does the organization discriminate by race in any way with respect to:
a Students' rights or privileges? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5a X
b Admissions policies? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5b X
c Employment of faculty or administrative staff? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5c X
d Scholarships or other financial assistance? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5d X
e Educational policies? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5e X
f Use of facilities? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5f X
g Athletic programs? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5g X
h Other extracurricular activities? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5h X
If you answered "Yes" to any of the above, please explain. If you need more space, use Part II.
6 a Does the organization receive any financial aid or assistance from a governmental agency? ~~~~~~~~~~~~~~~~ 6a X
b Has the organization's right to such aid ever been revoked or suspended? ~~~~~~~~~~~~~~~~~~~~~~~~~ 6b X
If you answered "Yes" on either line 6a or line 6b, explain on Part II.
7 Does the organization certify that it has complied with the applicable requirements of sections 4.01 through
4.05 of Rev. Proc. 75-50, 1975-2 C.B. 587, as modified by Rev. Proc. 2019-22, 2019-22 I.R.B. 1260, covering
racial nondiscrimination? If "No," explain on Part II •••••••••••••••••••••••••••••••••••• 7 X
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ. Schedule E (Form 990) 2022
232061 10-18-22
41
Schedule E (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part II Supplemental Information. Provide the explanations required by Part I, lines 3, 4d, 5h, 6b, and 7, as
applicable. Also provide any other additional information. See instructions.
LINE 6 - EXPLANATION OF GOVERNMENT FINANCIAL AID:
MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE/MAYO CLINIC RECEIVES FUNDS
FROM THE STATE OF MINNESOTA FOR MAYO CLINIC ALIX SCHOOL OF MEDICINE
STUDENTS WHO ARE RESIDENTS OF MINNESOTA.
IN ADDITION, FEDERAL DIRECT STUDENT LOANS (SUBSIDIZED, UNSUBSIDIZED,
PARENT PLUS AND GRADPLUS) ARE AVAILABLE FOR STUDENTS IN THE MAYO CLINIC
ALIX SCHOOL OF MEDICINE, MAYO CLINIC GRADUATE SCHOOL OF BIOMEDICAL
SCIENCES AND MAYO CLINIC SCHOOL OF HEALTH SCIENCES. FINALLY, QUALIFYING
UNDERGRADUATE STUDENTS IN THE MAYO CLINIC SCHOOL OF HEALTH SCIENCES ARE
ELIGIBLE FOR FUNDS FOR THE FEDERAL PELL GRANT PROGRAM.
232062 10-18-22 Schedule E (Form 990) 2022

42
OMB No. 1545-0047
SCHEDULE F Statement of Activities Outside the United States
(Form 990) Complete if the organization answered "Yes" on Form 990, Part IV, line 14b, 15, or 16.
Attach to Form 990.
2022
Department of the Treasury Open to Public

Part I General Information on Activities Outside the United States. Complete if the organization answered "Yes" on
Form 990, Part IV, line 14b.
1 For grantmakers. Does the organization maintain records to substantiate the amount of its grants and other assistance,
the grantees' eligibility for the grants or assistance, and the selection criteria used to award the grants or assistance? ~~ X Yes No
2 For grantmakers. Describe in Part V the organization's procedures for monitoring the use of its grants and other assistance outside the
United States.
3 Activities per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of (c) Number of (d) Activities conducted in the region (e) If activity listed in (d) (f) Total
offices employees, (by type) (such as, fundraising, pro- is a program service, expenditures
agents, and for and
in the region independent gram services, investments, grants to describe specific type
contractors investments
recipients located in the region) of service(s) in the region in the region
in the region
CENTRAL AMERICA AND

THE CARIBBEAN 0 105 TRAVEL 235,637.
EAST ASIA AND THE

PACIFIC 0 112 TRAVEL 356,107.
EUROPE (INCLUDING
ICELAND AND
GREENLAND) 0 893 TRAVEL 3,358,421.
MIDDLE EAST AND

NORTH AFRICA 0 75 TRAVEL 231,256.
NORTH AMERICA 0 367 TRAVEL 906,684.
RUSSIA AND THE

NEIGHBORING STATES 0 0 TRAVEL 0.
SOUTH AMERICA 0 36 TRAVEL 215,600.
SOUTH ASIA 0 35 TRAVEL 85,344.

3 a Subtotal ~~~~~~ 0 1623 5,389,049.
b Total from continuation
sheets to Part I ~~~ 2 58 3082293147.
c Totals (add lines 3a
and 3b) •••••• 2 1681 3087682196.
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990. Schedule F (Form 990) 2022
232071 10-17-22
43
Schedule F (Form 990) MAYO CLINIC 41-6011702 Page 1
Part I Continuation of Activities per Region. (Schedule F (Form 990), Part I, line 3)
(a) Region (b) Number of (c) Number of (d) Activities conducted in region (e) If activity listed in (d) (f) Total
offices employees or (by type) (i.e., fundraising, is a program service, expenditures
in the region agents in program services, grants to describe specific type for region
region recipients located in the region) of service(s) in region
SUB-SAHARAN AFRICA 0 15 TRAVEL 52,786.
EAST ASIA AND THE

PACIFIC 0 4 PROGRAM SERVICES PATIENT CARE 124,203.
EUROPE (INCLUDING
ICELAND AND
GREENLAND) 0 5 PROGRAM SERVICES PATIENT CARE 97,530.
MIDDLE EAST AND

NORTH AFRICA 0 10 PROGRAM SERVICES PATIENT CARE 285,569.
EUROPE (INCLUDING
ICELAND AND
GREENLAND) 0 1 PROGRAM SERVICES RESEARCH 107,043.
EDUCATION CONFERENCE -
NORTH AMERICA 0 2 PROGRAM SERVICES MAYO SPONSOR 221,616.
CENTRAL AMERICA AND

THE CARIBBEAN 0 0 INVESTMENTS 873,793,287.
EAST ASIA AND THE

PACIFIC 0 0 INVESTMENTS 1,166,061,076.
EUROPE (INCLUDING
ICELAND AND
GREENLAND) 1 0 INVESTMENTS 646,315,337.
MIDDLE EAST AND

NORTH AFRICA 0 0 INVESTMENTS 183,255,328.
Totals ••••••••• |
232181
04-01-22
44
NORTH AMERICA 0 0 INVESTMENTS 98,009,490.
RUSSIA AND THE

NEIGHBORING STATES 0 0 INVESTMENTS 0.
SOUTH AMERICA 0 0 INVESTMENTS 13,885,800.
SOUTH ASIA 0 0 INVESTMENTS 74,038,853.
SUB-SAHARAN AFRICA 0 0 INVESTMENTS 7,511,828.
EAST ASIA AND THE REFERENCE LAB SALES &

PACIFIC 1 5 UNRELATED BUSINESS ACTIVITY MARKETING 1,519,211.
MIDDLE EAST AND REFERENCE LAB SALES &

NORTH AFRICA 0 4 UNRELATED BUSINESS ACTIVITY MARKETING 1,551,177.
REFERENCE LAB SALES &

NORTH AMERICA 0 7 UNRELATED BUSINESS ACTIVITY MARKETING 1,085,384.
REFERENCE LAB SALES &

SOUTH AMERICA 0 4 UNRELATED BUSINESS ACTIVITY MARKETING 372,521.
EAST ASIA AND THE

PACIFIC 0 0 PROGRAM SERVICES CONSULTING 0.
Totals ••••••••• |
232181
04-01-22
45
EUROPE (INCLUDING
ICELAND AND
GREENLAND) 0 0 PROGRAM SERVICES RESEARCH 0.
EUROPE (INCLUDING
ICELAND AND EDUCATION CONFERENCE -
GREENLAND) 0 1 PROGRAM SERVICES MAYO SPONSOR 6,475.
EUROPE (INCLUDING
ICELAND AND
GREENLAND) 0 0 FUNDRAISING 0.
EAST ASIA AND THE

PACIFIC 0 0 INVESTMENTS EXPENSE 0.
EUROPE (INCLUDING
ICELAND AND
GREENLAND) 0 0 INVESTMENTS EXPENSE 13,998,633.
Totals ••••••••• | 2 58 3082293147.
232181
04-01-22
46
Schedule F (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part II Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any
recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (g) Amount of (h) Description (i) Method of

(b) IRS code section (d) Purpose of (e) Amount (f) Manner of
(a) Name of organization (c) Region noncash of noncash valuation (book, FMV,
and EIN (if applicable) grant of cash grant cash disbursement assistance assistance appraisal, other)
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
ALBANIA, ANDORRA, 101,216. 0.
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
EAST ASIA AND THE
PACIFIC -
AUSTRALIA,
BRUNEI, BURMA, 29,400. 0.
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as a tax
exempt 501(c)(3) organization by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter ~~~~~~~ |
3 Enter total number of other organizations or entities ••••••••••••••••••••••••••••••••••••••••••••• |
Schedule F (Form 990) 2022
232072 10-17-22 47
Part II Continuation of Grants and Other Assistance to Organizations or Entities Outside the United States. (Schedule F (Form 990), Part II, line 1)
(a) Name of organization (c) Region non-cash of non-cash valuation (book, FMV,
SOUTH ASIA -
AFGHANISTAN,
BANGLADESH,
BHUTAN, INDIA, 52,056. 0.
EAST ASIA AND THE
PACIFIC -
AUSTRALIA,
BRUNEI, BURMA, 249,743. 0.
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
NORTH AMERICA -
CANADA AND
MEXICO, BUT NOT
THE UNITED STATES 72,912. 0.
NORTH AMERICA -
CANADA AND
MEXICO, BUT NOT
EUROPE (INCLUDING
ICELAND &
GREENLAND) -
NORTH AMERICA -
CANADA AND
MEXICO, BUT NOT
SUB-SAHARAN
AFRICA 40,103. 0.
232182
04-01-22 48
Part II Continuation of Grants and Other Assistance to Organizations or Entities Outside the United States. (Schedule F (Form 990), Part II, line 1)
(a) Name of organization (c) Region non-cash of non-cash valuation (book, FMV,
EUROPE (INCLUDING
ICELAND &
GREENLAND) 275,000. 0.
EUROPE (INCLUDING
ICELAND &
EUROPE (INCLUDING
ICELAND &
EUROPE (INCLUDING
ICELAND &
NORTH AMERICA 33,659. 0.
EUROPE (INCLUDING
ICELAND &
EUROPE (INCLUDING
ICELAND &
232182
04-01-22 49
Part III Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(c) Number of (d) Amount of (e) Manner of (f) Amount of (g) Description of (h) Method of
(a) Type of grant or assistance (b) Region recipients cash grant cash disbursement noncash noncash assistance valuation
assistance (book, FMV,
appraisal, other)
232073 10-17-22 50
Part IV Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes,"
the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign
Corporation (see Instructions for Form 926) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X Yes No
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may
be required to separately file Form 3520, Annual Return To Report Transactions With Foreign Trusts and
Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a
U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990) ~~~~~~~~~~~~~~~~~ Yes X No
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes,"
the organization may be required to file Form 5471, Information Return of U.S. Persons With Respect to
Certain Foreign Corporations (see Instructions for Form 5471) ~~~~~~~~~~~~~~~~~~~~~~~~~~~ X Yes No
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a
qualified electing fund during the tax year? If "Yes," the organization may be required to file Form 8621,
Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing
Fund (see Instructions for Form 8621) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X Yes No
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes,"
the organization may be required to file Form 8865, Return of U.S. Persons With Respect to Certain
Foreign Partnerships (see Instructions for Form 8865) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X Yes No
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If
"Yes," the organization may be required to separately file Form 5713, International Boycott Report (see
Instructions for Form 5713; don't file with Form 990) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X Yes No
232074 10-17-22
51
Part V Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of
investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c)
(estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.
PART I, LINE 2:
FEDERAL AWARDS THAT ARE SUBCONTRACTED TO OTHER ORGANIZATIONS ARE
REGULARLY MONITORED BY THE FILING ORGANIZATION FOR COMPLIANCE WITH EITHER
THE FEDERAL REGULATIONS AND/OR THE CONTRACT PROVISIONS. SEE ALSO
SCHEDULE I, PART IV FOR ADDITIONAL INFORMATION ON MAYO CLINIC'S
PROCEDURES FOR MONITORING THE USE OF GRANT FUNDS AS THE SAME PROCEDURES
APPLY TO DOMESTIC AND FOREIGN GRANTS.
GENERAL INFORMATION ON ACTIVITIES OUTSIDE THE UNITED STATES IS REPORTED
BASED ON WHERE PAYMENTS WERE REMITTED. OUR CURRENT REPORTING SYSTEM DOES
NOT TRACK ACTIVITIES OUTSIDE THE UNITED STATES BY LOCATION OF SERVICE.
PART I, LINE 3:
ACCRUAL METHOD
PART IV - FILING OF CERTAIN FOREIGN FORMS
DISCLOSURE STATEMENT RELATED TO FORMS 5713:
FORM 5713 HAS BEEN FILED BY THE FOLLOWING MEMBERS OF THE CONTROLLED
GROUP:
MAYO CLINIC (EIN: 41-6011702)
MAYO CLINIC ARIZONA (EIN: 86-0800150)
MAYO CLINIC JACKSONVILLE (EIN: 59-3337028)
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (EIN: 41-1506440)
UNDER THE CONSTRUCTIVE OWNERSHIP RULES OF IRC SECTIONS 958(A) AND (B),
232075 10-17-22 Schedule F (Form 990) 2022
52
THE TAXPAYER IS REQUIRED TO FILE FORMS 5471, INFORMATION RETURN OF U.S.
PERSONS WITH RESPECT TO CERTAIN FOREIGN CORPORATIONS, AS A CATEGORY 4
AND 5 FILER WITH RESPECT TO THE CONTROLLED FOREIGN CORPORATIONS (CFCS).
THESE FILING REQUIREMENTS ARE OR WILL BE SATISFIED THROUGH THE FILING
OF FORMS 5471 FOR THESE CFCS BY OTHER U.S. TAXPAYERS IDENTIFIED BELOW
WHO HAVE THE SAME FILING REQUIREMENT.
TAXPAYER NAME: MAYO CLINIC
ADDRESS: 200 FIRST STREET SW, ROCHESTER, MN 55905
ID NUMBER OF U.S. TAX RETURN WITH FORMS 5471 WAS FILED: 41-6011702
IRS SERVICE CENTER WHERE U.S. TAX RETURN WAS OR WILL BE FILED: OGDEN,
UT
TAXPAYER NAME: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
UT
UNDER THE CONSTRUCTIVE OWNERSHIP RULES OF IRC SECTIONS 958(A) AND (B),
THE TAXPAYER IS REQUIRED TO FILE FORMS 8865, INFORMATION RETURN OF U.S.
PERSONS WITH RESPECT TO CERTAIN FOREIGN PARTNERSHIPS (CFPS), AS A
CATEGORY 2 AND 3 FILER. THESE FILING REQUIREMENTS ARE OR WILL BE
SATISFIED THROUGH THE FILING OF FORMS 8865 FOR THESE PARTNERSHIPS BY
OTHER U.S. TAXPAYERS IDENTIFIED BELOW WHO HAVE THE SAME FILING
REQUIREMENT.
232075 10-17-22 Schedule F (Form 990) 2022
53
TAXPAYER NAME: MAYO CLINIC
UT
232075 10-17-22 Schedule F (Form 990) 2022

54
SCHEDULE G Supplemental Information Regarding Fundraising or Gaming Activities OMB No. 1545-0047
(Form 990) Complete if the organization answered "Yes" on Form 990, Part IV, line 17, 18, or 19, or if the
organization entered more than $15,000 on Form 990-EZ, line 6a. 2022
Part I Fundraising Activities. Complete if the organization answered "Yes" on Form 990, Part IV, line 17. Form 990-EZ filers are not
required to complete this part.
1 Indicate whether the organization raised funds through any of the following activities. Check all that apply.
a X Mail solicitations e X Solicitation of non-government grants
b X Internet and email solicitations f X Solicitation of government grants
c X Phone solicitations g Special fundraising events
d X In-person solicitations
2 a Did the organization have a written or oral agreement with any individual (including officers, directors, trustees, or
key employees listed in Form 990, Part VII) or entity in connection with professional fundraising services? X Yes No
b If "Yes," list the 10 highest paid individuals or entities (fundraisers) pursuant to agreements under which the fundraiser is to be
compensated at least $5,000 by the organization.
(iii) Did (v) Amount paid (vi) Amount paid

(i) Name and address of individual fundraiser (iv) Gross receipts to (or retained by)
(ii) Activity have custody
fundraiser to (or retained by)
or entity (fundraiser) or control of from activity organization
contributions? listed in col. (i)
TRUESENSE MARKETING - 502 Yes No
KEYSTONE DRIVE, WARRENDAL, PA CONSULTING X 0. 549,956. 0.
THE STELTER COMPANY - 10435
NEW YORK AVE, DES MOINES, IA DIRECT MAIL SERVICES X 0. 85,536. 0.
QCSS - 21925 FIELD PARKWAY, SERVICES-THANK YOU
SUITE 210, DEER PARK, IL CALLS/CARDS X 0. 12,308. 0.
MARKETEAM - 600 NORTHPARK
TOWN CENTER, SUITE 400, CONSULTING X 0. 255,000. 0.
Total •••••••••••••••••••••••••••••••••••••••• 902,800.

3 List all states in which the organization is registered or licensed to solicit contributions or has been notified it is exempt from registration
or licensing.
AL,AK,AZ,AR,CA,CO,CT,DE,FL,GA,HI,ID,IL,IN,IA,KS,KY,LA,ME,MD,MA,MI,MN,MS,MO
MT,NE,NV,NH,NJ,NM,NY,NC,ND,OH,OK,OR,PA,RI,SC,SD,TN,TX,UT,VT,VA,WA,WV,WI,WY
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ. Schedule G (Form 990) 2022
SEE PART IV FOR CONTINUATIONS
232081 10-27-22
55
Schedule G (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part II Fundraising Events. Complete if the organization answered "Yes" on Form 990, Part IV, line 18, or reported more than $15,000
of fundraising event contributions and gross income on Form 990-EZ, lines 1 and 6b. List events with gross receipts greater than $5,000.
(a) Event #1 (b) Event #2 (c) Other events
(d) Total events
(add col. (a) through
col. (c))
(event type) (event type) (total number)
Revenue
1 Gross receipts ~~~~~~~~~~~~~~
2 Less: Contributions ~~~~~~~~~~~
3 Gross income (line 1 minus line 2) ••••
4 Cash prizes ~~~~~~~~~~~~~~~
5 Noncash prizes ~~~~~~~~~~~~~

Direct Expenses
6 Rent/facility costs ~~~~~~~~~~~~
7 Food and beverages ~~~~~~~~~~
8 Entertainment ~~~~~~~~~~~~~~
9 Other direct expenses ~~~~~~~~~~
10 Direct expense summary. Add lines 4 through 9 in column (d) ~~~~~~~~~~~~~~~~~~~~~~~~~~
11 Net income summary. Subtract line 10 from line 3, column (d) ••••••••••••••••••••••••••
Part III Gaming. Complete if the organization answered "Yes" on Form 990, Part IV, line 19, or reported more than
$15,000 on Form 990-EZ, line 6a.
(b) Pull tabs/instant (d) Total gaming (add
(a) Bingo (c) Other gaming
Revenue
bingo/progressive bingo col. (a) through col. (c))
1 Gross revenue ••••••••••••••
2 Cash prizes ~~~~~~~~~~~~~~~

Direct Expenses
3 Noncash prizes ~~~~~~~~~~~~~
4 Rent/facility costs ~~~~~~~~~~~~
5 Other direct expenses ••••••••••

Yes % Yes % Yes %
6 Volunteer labor ~~~~~~~~~~~~~ No No No
7 Direct expense summary. Add lines 2 through 5 in column (d) ~~~~~~~~~~~~~~~~~~~~~~~~~~
8 Net gaming income summary. Subtract line 7 from line 1, column (d) •••••••••••••••••••••••
9 Enter the state(s) in which the organization conducts gaming activities:

a Is the organization licensed to conduct gaming activities in each of these states? ~~~~~~~~~~~~~~~~~~~~ Yes No
b If "No," explain:
10a Were any of the organization's gaming licenses revoked, suspended, or terminated during the tax year?~~~~~~~~~ Yes No
b If "Yes," explain:
232082 10-27-22 Schedule G (Form 990) 2022
56
Schedule G (Form 990) 2022 MAYO CLINIC 41-6011702 Page 3
11 Does the organization conduct gaming activities with nonmembers?~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
12 Is the organization a grantor, beneficiary or trustee of a trust, or a member of a partnership or other entity formed
to administer charitable gaming? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
13 Indicate the percentage of gaming activity conducted in:
a The organization's facility ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 13a %
b An outside facility ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 13b %
14 Enter the name and address of the person who prepares the organization's gaming/special events books and records:
Name
Address
15a Does the organization have a contract with a third party from whom the organization receives gaming revenue? ~~~~~~ Yes No
b If "Yes," enter the amount of gaming revenue received by the organization $ and the amount
of gaming revenue retained by the third party $
c If "Yes," enter name and address of the third party:
Name
Address
16 Gaming manager information:
Name
Gaming manager compensation $
Description of services provided
Director/officer Employee Independent contractor
17 Mandatory distributions:
a Is the organization required under state law to make charitable distributions from the gaming proceeds to
retain the state gaming license? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Yes No
b Enter the amount of distributions required under state law to be distributed to other exempt organizations or spent in the
organization's own exempt activities during the tax year $
Part IV Supplemental Information. Provide the explanations required by Part I, line 2b, columns (iii) and (v); and Part III, lines 9, 9b, 10b,
15b, 15c, 16, and 17b, as applicable. Also provide any additional information. See instructions.
SCHEDULE G, PART I, LINE 2B, LIST OF TEN HIGHEST PAID FUNDRAISERS:
(I) NAME OF FUNDRAISER: TRUESENSE MARKETING
(I) ADDRESS OF FUNDRAISER: 502 KEYSTONE DRIVE, WARRENDAL, PA 15086
(I) NAME OF FUNDRAISER: THE STELTER COMPANY
(I) ADDRESS OF FUNDRAISER: 10435 NEW YORK AVE, DES MOINES, IA 50322
(I) NAME OF FUNDRAISER: QCSS

232083 10-27-22 Schedule G (Form 990) 2022
57
Schedule G (Form 990) MAYO CLINIC 41-6011702 Page 4
(I) ADDRESS OF FUNDRAISER:
21925 FIELD PARKWAY, SUITE 210, DEER PARK, IL 60010
(I) NAME OF FUNDRAISER: MARKETEAM
(I) ADDRESS OF FUNDRAISER:
600 NORTHPARK TOWN CENTER, SUITE 400, ATLANTA, GA 30328
PART I, LINE 2B, COLUMN (V):
PAYMENTS MADE TO FUNDRAISERS WERE FOR SERVICES PROVIDED TO MAYO CLINIC IN
RELATION TO FUNDRAISING CONDUCTED EXCLUSIVELY BY MAYO CLINIC.
Schedule G (Form 990)

232084 04-01-22
58
SCHEDULE I Grants and Other Assistance to Organizations, OMB No. 1545-0047
(Form 990) Governments, and Individuals in the United States

Complete if the organization answered "Yes" on Form 990, Part IV, line 21 or 22.
2022
Go to www.irs.gov/Form990 for the latest information. Inspection
Part I General Information on Grants and Assistance
1 Does the organization maintain records to substantiate the amount of the grants or assistance, the grantees' eligibility for the grants or assistance, and the selection
criteria used to award the grants or assistance? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X Yes No
2 Describe in Part IV the organization's procedures for monitoring the use of grant funds in the United States.
Part II Grants and Other Assistance to Domestic Organizations and Domestic Governments. Complete if the organization answered "Yes" on Form 990, Part IV, line 21, for any
recipient that received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name and address of organization (b) EIN (c) IRC section (d) Amount of (e) Amount of (f) Method of (g) Description of (h) Purpose of grant
valuation (book,
or government (if applicable) cash grant noncash noncash assistance or assistance
FMV, appraisal,
assistance other)
MAYO CLINIC ARIZONA

13400 EAST SHEA BOULEVARD SUPPORT CHARITABLE
SCOTTSDALE, AZ 85259 86-0800150 501(C)(3) 120,978,669. 0. PROGRAMS
MAYO CLINIC JACKSONVILLE

4500 SAN PABLO ROAD SUPPORT CHARITABLE
JACKSONVILLE, FL 32224 59-3337028 501(C)(3) 102,484,136. 0. PROGRAMS
MCHS--SOUTHEAST MINNESOTA REGION

1000 FIRST DRIVE N.W. SUPPORT CHARITABLE
AUSTIN, MN 55912 41-1404075 501(C)(3) 14,562,989. 0. PROGRAMS
MCHS--SOUTHWEST MINNESOTA REGION

1025 MARSH STREET SUPPORT CHARITABLE
MANKATO, MN 56001 41-1236756 501(C)(3) 4,340,198. 0. PROGRAMS
REGEN THERANOSTICS INC

3033 41ST STREET NW STE 200
ROCHESTER, MN 55901 27-1652200 - 3,158,992. 0. SUPPORT RESEARCH PROGRAM
BOSTON SCIENTIFIC CORPORATION

300 BOSTON SCIENTIFIC WAY
MARLBOROUGH, MA 01752 04-2695240 - 2,965,085. 0. SUPPORT RESEARCH PROGRAM
2 Enter total number of section 501(c)(3) and government organizations listed in the line 1 table ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 221.
3 Enter total number of other organizations listed in the line 1 table •••••••••••••••••••••••••••••••••••••••••••••••••••• 24.
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990. Schedule I (Form 990) 2022
232101 10-31-22 59
Schedule I (Form 990) MAYO CLINIC 41-6011702 Page 1
Part II Continuation of Grants and Other Assistance to Domestic Organizations and Domestic Governments (Schedule I (Form 990), Part II.)
(a) Name and address of (b) EIN (c) IRC section (d) Amount of (e) Amount of (f) Method of (g) Description of (h) Purpose of grant
organization or government if applicable cash grant noncash valuation non-cash assistance or assistance
appraisal, other)
UNIVERSITY OF CALIFORNIA, SAN

FRANCISCO - 220 MONTGOMERY ST FL 5
- SAN FRANCISCO, CA 94104 94-6036493 STATE OF CA 2,926,232. 0. SUPPORT RESEARCH PROGRAM
REGENTS OF THE UNIVERSITY OF

MINNESOTA - 1300 S 2ND ST STE 206
- MINNEAPOLIS, MN 55454 41-6007513 STATE OF MN 2,527,396. 0. SUPPORT RESEARCH PROGRAM
MCHS--NORTHWEST WISCONSIN REGION,

INC. - 1221 WHIPPLE STREET - EAU SUPPORT CHARITABLE
CLAIRE, WI 54703 39-0813418 501(C)(3) 2,099,380. 0. PROGRAMS
MCHS--FAIRMONT
800 MEDICAL CENTER DRIVE, PO BOX 8 SUPPORT CHARITABLE
FAIRMONT, MN 56031 41-0760836 501(C)(3) 2,034,091. 0. PROGRAMS
DUKE UNIVERSITY
324 BLACKWELL ST WASHIN BLDG NO 85 SUPPORT CHARITABLE
DURHAM, NC 27701 56-0532129 501(C)(3) 1,478,633. 0. PROGRAMS
THE TRUSTEES OF COLUMBIA
UNIVERSITY IN THE CITY OF NEW YORK
- 615 WEST 131ST STREET MC 8741 - SUPPORT CHARITABLE
NEW YORK, NY 10027 13-5598093 501(C)(3) 1,342,994. 0. PROGRAMS
EMORY UNIVERSITY
1599 CLIFTON ROAD 3RD FLOOR 3101 SUPPORT CHARITABLE
ATLANTA, GA 30322 58-0566256 501(C)(3) 1,264,696. 0. PROGRAMS
NEXUS FAMILY HEALING

505 HIGHWAY 169 N NO 500 SUPPORT CHARITABLE
PLYMOUTH, MN 55441 41-1419064 501(C)(3) 1,166,667. 0. PROGRAMS
THE UNIVERSITY OF TEXAS M D
ANDERSON CANCER CENTER - 1515
HOLCOMBE BOULEVARD - HOUSTON, TX
77030 74-6001118 STATE OF TX 1,163,680. 0. SUPPORT RESEARCH PROGRAM
Schedule I (Form 990)
232241
04-01-22 60
appraisal, other)
MAYO FOUNDATION FOR MEDICAL

EDUCATION AND RESEARCH - 200 FIRST SUPPORT CHARITABLE
STREET S.W. - ROCHESTER, MN 55905 41-1506440 501(C)(3) 942,601. 0. PROGRAMS
INDIANA UNIVERSITY
1001 E THIRD STREET
BLOOMINGTON, IN 47405-7005 35-6001673 STATE OF IN 858,252. 0. SUPPORT RESEARCH PROGRAM
THOUGHT LEADERSHIP & INNOVATION

FOUNDATION - 1750 TYSONS BOULEVARD SUPPORT CHARITABLE
NO 1500 - MCLEAN, VA 22102 45-3090698 501(C)(3) 803,351. 0. PROGRAMS
YALE UNIVERSITY
PO BOX 208239 SUPPORT CHARITABLE
NEW HAVEN, CT 06520 06-0646973 501(C)(3) 801,518. 0. PROGRAMS
TRUSTEES OF THE UNIVERSITY OF
PENNSYLVANIA - 3451 WALNUT STREET
SUITE 305 - PHILADELPHIA, PA SUPPORT CHARITABLE
19104-6284 23-1352685 501(C)(3) 645,497. 0. PROGRAMS
THE OHIO STATE UNIVERSITY

1960 KENNY RD
COLUMBUS, OH 43210 31-6025986 STATE OF OH 641,418. 0. SUPPORT RESEARCH PROGRAM
TRUSTED SEMICONDUCTOR SOLUTION

7101 NORTHLAND CIR N
BROOKLYN PARK, MN 55428-1517 20-5414682 - 600,650. 0. SUPPORT RESEARCH PROGRAM
THE GENERAL HOSPITAL CORPORATION

399 REVOLUTION DRIVE NO 645 SUPPORT CHARITABLE
SOMERVILLE, MA 02145 04-2697983 501(C)(3) 586,627. 0. PROGRAMS
UNIVERSITY OF CALIFORNIA LOS

ANGELES - 10889 WILSHIRE BOULEVARD
STE 700 - LOS ANGELES, CA 90095 95-6006143 STATE OF CA 563,734. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 61
appraisal, other)
THE UNIVERSITY OF IOWA

105 JESSUP HALL
IOWA CITY, IA 52242 42-6004813 STATE OF IA 533,463. 0. SUPPORT RESEARCH PROGRAM
OREGON HEALTH & SCIENCE UNIVERSITY

3181 SW SAM JACKSON PARK ROAD
PORTLAND, OR 97239 93-1176109 STATE OF OR 482,007. 0. SUPPORT RESEARCH PROGRAM
GE PRECISION HEALTHCARE LLC

3000 N GRANDVIEW BLVD
WAUKESHA, WI 53188 83-0849145 - 459,750. 0. SUPPORT RESEARCH PROGRAM
THE UNIVERSITY OF TEXAS HEALTH

SCIENCE CENTER AT HOUSTON - PO BOX
301418 - DALLAS, TX 75303-1418 74-1761309 STATE OF TX 433,618. 0. SUPPORT RESEARCH PROGRAM
UNITED WAY OF OLMSTED COUNTY INC

903 WEST CENTER STREET NO 100 SUPPORT CHARITABLE
ROCHESTER, MN 55902 41-0695594 501(C)(3) 425,000. 0. PROGRAMS
THE UNIVERSITY OF TEXAS HEALTH
SCIENCE CENTER AT SAN ANTONIO -
7703 FLOYD CURL DR - SAN ANTONIO,
TX 78229-3900 74-1586031 STATE OF TX 423,183. 0. SUPPORT RESEARCH PROGRAM
MAINEHEALTH
22 BRAMHALL STREET SUPPORT CHARITABLE
PORTLAND, ME 04102 01-0238552 501(C)(3) 415,238. 0. PROGRAMS
REGENTS OF THE UNIVERSITY OF

MICHIGAN - 503 THOMPSON ST - ANN
ARBOR, MI 48109 38-6006309 STATE OF MI 404,131. 0. SUPPORT RESEARCH PROGRAM
THE ROCKEFELLER UNIVERSITY

1230 YORK AVENUE SUPPORT CHARITABLE
NEW YORK, NY 10065 13-1624158 501(C)(3) 401,654. 0. PROGRAMS
232241
04-01-22 62
appraisal, other)
WASHINGTON UNIVERSITY
700 ROSEDALE AVENUE CB 1034 SUPPORT CHARITABLE
SAINT LOUIS, MO 63112 43-0653611 501(C)(3) 382,683. 0. PROGRAMS
SANFORD BURNHAM PREBYS MEDICAL
DISCOVERY INSTITUTE - 10901 NORTH
TORREY PINES ROAD - LA JOLLA, CA SUPPORT CHARITABLE
92037 51-0197108 501(C)(3) 353,229. 0. PROGRAMS
UNIVERSITY OF WASHINGTON
4333 BROOKLYN AVE NE
SEATTLE, WA 98195 91-6001537 STATE OF WA 346,792. 0. SUPPORT RESEARCH PROGRAM
AMERICAN ACADEMY OF FAMILY

PHYSICIANS - 11400 TOMAHAWK CREEK
PARKWAY - LEAWOOD, KS 66211-2672 44-0536051 501(C)(6) 337,422. 0. SUPPORT EXEMPT PURPOSE
THE BRIGHAM AND WOMEN'S HOSPITAL

INC - 339 REVOLUTION DRIVE NO 645 SUPPORT CHARITABLE
- SOMERVILLE, MA 02145 04-2312909 501(C)(3) 323,231. 0. PROGRAMS
ARIZONA STATE UNIVERSITY

PO BOX 875812
TEMPE, AZ 85287 86-0196696 STATE OF AZ 315,845. 0. SUPPORT RESEARCH PROGRAM
ROCHESTER DOWNTOWN ALLIANCE

311 SOUTH BROADWAY SUITE A2
ROCHESTER, MN 55904 20-2435646 501(C)(6) 315,182. 0. SUPPORT EXEMPT PURPOSE
JOHNS HOPKINS UNIVERSITY

3910 KESWICK ROAD NO N4327B SUPPORT CHARITABLE
BALTIMORE, MD 21211 52-0595110 501(C)(3) 288,128. 0. PROGRAMS
UNIVERSITY OF UTAH
201 PRESIDENTS CIRCLE RM 411
SALT LAKE CITY, UT 84112 87-6000525 STATE OF UT 287,999. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 63
appraisal, other)
THE METHODIST HOSPITAL RESEARCH

INSTITUTE - 6565 FANNIN ST. - SUPPORT CHARITABLE
HOUSTON, TX 77030 87-0721923 501(C)(3) 282,344. 0. PURPOSE
MCHS--FRANCISCAN MEDICAL CENTER,

INC. - 700 WEST AVE SOUTH - LA SUPPORT CHARITABLE
CROSSE, WI 54601 39-0806374 501(C)(3) 274,557. 0. PROGRAMS
THE CHILDREN'S HOSPITAL OF

PHILADELPHIA - 3401 CIVIC CENTER SUPPORT CHARITABLE
BOULEVARD - PHILADELPHIA, PA 19104 23-1352166 501(C)(3) 268,428. 0. PROGRAMS
HEALTHPARTNERS INSTITUTE
8170 33RD AVENUE SOUTH SUPPORT CHARITABLE
MINNEAPOLIS, MN 55440-1309 41-1670163 501(C)(3) 261,306. 0. PROGRAMS
NFERENCE INC
ONE MAIN STREET STE 400
CAMBRIDGE, MA 02142 46-1833049 - 261,216. 0. SUPPORT RESEARCH PROGRAM
MOUNTAIN PARK HEALTH CENTER

3003 NORTH CENTRAL AVENUE SUITE 16 SUPPORT CHARITABLE
PHOENIX, AZ 85012 86-0498020 501(C)(3) 258,890. 0. PROGRAMS
WEILL MEDICAL COLLEGE OF CORNELL

UNIVERSITY - 1300 YORK AVENUE - SUPPORT CHARITABLE
NEW YORK, NY 10065 13-1623978 501(C)(3) 246,866. 0. PURPOSE
UNIVERSITY OF FLORIDA
207 GRINTER HALL
GAINESVILLE, FL 32611 59-6002052 STATE OF FL 236,924. 0. SUPPORT RESEARCH PROGRAM
THE BOARD OF TRUSTEES OF THE
UNIVERSITY OF ILLINOIS - 506 S
WRIGHT ST RM 209 - URBANA, IL
61801 37-6000511 STATE OF IL 228,895. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 64
appraisal, other)
THE LANDING MN INC

718 22ND STREET NE SUPPORT CHARITABLE
ROCHESTER, MN 55906 83-2953783 501(C)(3) 223,800. 0. PURPOSE
DANA-FARBER CANCER INSTITUTE INC

450 BROOKLINE AVENUE BP418 SUPPORT CHARITABLE
BOSTON, MA 02215 04-2263040 501(C)(3) 222,085. 0. PROGRAMS
THE FTD DISORDERS REGISTRY LLC

2700 HORIZON DRIVE SUPPORT CHARITABLE
KING OF PRUSSIA, PA 19406 47-3601782 501(C)(3) 221,422. 0. PROGRAMS
WAKE FOREST UNIVERSITY HEALTH

SCIENCES - MEDICAL CENTER BLVD - SUPPORT CHARITABLE
WINSTON SALEM, NC 27157 22-3849199 501(C)(3) 220,884. 0. PROGRAMS
UNIVERSITY OF WISCONSIN-MADISON
21 N PARK STREET SUITE 6401
MADISON, WI 53715 39-6006492 STATE OF WI 219,779. 0. SUPPORT RESEARCH PROGRAM
ARIZONA ASSOCIATION OF COMMUNITY
HEALTH CENTERS INC - 700 E
JEFFERSON STREET SUITE 100 - SUPPORT CHARITABLE
VANDERBILT UNIVERSITY
PMB 406310 2301 VANDERBILT PLACE SUPPORT CHARITABLE
NASHVILLE, TN 37240 62-0476822 501(C)(3) 212,861. 0. PROGRAMS
UNIVERSITY OF ROCHESTER
BOX 278893 SUPPORT CHARITABLE
ROCHESTER, NY 14627 16-0743209 501(C)(3) 205,187. 0. PROGRAMS
RINCON RESEARCH CORPORATION

101 N WILMONT RD
TUCSON, AZ 85711 86-0465180 - 198,949. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 65
appraisal, other)
THE SALVATION ARMY NORTHERN

DIVISION - 2445 PRIOR AVENUE NORTH SUPPORT CHARITABLE
- ROSEVILLE, MN 55113 41-0698597 501(C)(3) 192,675. 0. PROGRAMS
NORTH CAROLINA STATE UNIVERSITY

2601 WOLF VILLAGE WAY SUITE 240
RALEIGH, NC 27695 56-6000756 STATE OF NC 186,739. 0. SUPPORT RESEARCH PROGRAM
WASHINGTON STATE UNIVERSITY

240 FRENCH ADMINISTRATION BLDG
PULLMAN, WA 99164 91-6001108 STATE OF WA 184,627. 0. SUPPORT RESEARCH PROGRAM
TEXAS A&M UNIVERSITY

400 HARVEY MITCHELL PKY S STE 300
COLLEGE STATION, TX 77845 74-6000531 STATE OF TX 183,346. 0. SUPPORT RESEARCH PROGRAM
GEORGIA TECH RESEARCH CORPORATION

926 DALNEY STREET NW SUPPORT CHARITABLE
ATLANTA, GA 30332-0415 58-0603146 501(C)(3) 181,162. 0. PROGRAMS
INDESIGN LLC
8225 E 56TH ST
INDIANAPOLIS, IN 46216 35-2003601 - 178,892. 0. SUPPORT RESEARCH PROGRAM
NEW YORK UNIVERSITY

105 E 17TH STREET 2ND FLOOR SUPPORT CHARITABLE
NEW YORK, NY 10003 13-5562309 501(C)(3) 172,492. 0. PURPOSE
UNIVERSITY OF CALIFORNIA SAN DIEGO

9500 GILMAN DRIVE
LA JOLLA, CA 92093 95-6006144 STATE OF CA 167,624. 0. SUPPORT RESEARCH PROGRAM
HAZELDEN BETTY FORD FOUNDATION

CENTER CITY, MN 55012 41-0682405 501(C)(3) 157,948. 0. PROGRAMS
232241
04-01-22 66
appraisal, other)
UNIVERSITY OF ALABAMA AT
BIRMINGHAM - 701 S 20TH ST -
BIRMINGHAM, AL 35294 63-6005396 STATE OF AL 155,941. 0. SUPPORT RESEARCH PROGRAM
HENNEPIN HEALTHCARE RESEARCH

INSTITUTE - 701 PARK AVENUE - SUPPORT CHARITABLE
MINNEAPOLIS, MN 55415 41-1677920 501(C)(3) 154,369. 0. PROGRAMS
UNCONVENTIONAL INNOVATION LLC

3507 SHELBY RD
LYNNWOOD, WA 98087 84-3491937 - 141,000. 0. SUPPORT RESEARCH PROGRAM
AMERICAN NATIONAL RED CROSS

431 18TH STREET NW SUPPORT CHARITABLE
WASHINGTON, DC 20006-5009 53-0196605 501(C)(3) 140,000. 0. PROGRAMS
UNIVERSITY OF NORTH CAROLINA AT
CHAPEL HILL - 103 SOUTH BUILDING
CAMPUS BOX 9100 - CHAPEL HILL, NC
27599 56-6001393 STATE OF NC 136,637. 0. SUPPORT RESEARCH PROGRAM
YALE NEW HAVEN HEALTH SERVICES

CORPORATION - 789 HOWARD AVENUE - SUPPORT CHARITABLE
NEW HAVEN, CT 06519 22-2529464 501(C)(3) 128,100. 0. PROGRAMS
NORTHERN CALIFORNIA INSTITUTE FOR
RESEARCH AND EDUCATION INC - 4150
CLEMENT STREET 151NC - SAN SUPPORT CHARITABLE
FRANCISCO, CA 94121 94-3084159 501(C)(3) 126,414. 0. PROGRAMS
MPR ASSOCIATES INC

320 KING ST
ALEXANDRIA, VA 22314-3230 52-0804505 - 121,596. 0. SUPPORT RESEARCH PROGRAM
HENRY FORD HEALTH SYSTEM

ONE FORD PLACE-5F SUPPORT CHARITABLE
DETROIT, MI 48202 38-1357020 501(C)(3) 120,457. 0. PROGRAMS
232241
04-01-22 67
appraisal, other)
DUKE UNIVERSITY HEALTH SYSTEM INC

324 BLACKWELL ST WASHIN BLDG N SUPPORT CHARITABLE
DURHAM, NC 27701 56-2070036 501(C)(3) 116,921. 0. PROGRAMS
NORTHWESTERN UNIVERSITY
633 CLARK ST SUPPORT CHARITABLE
EVANSTON, IL 60208 36-2167817 501(C)(3) 116,904. 0. PROGRAMS
THE UNIVERSITY OF TEXAS
SOUTHWESTERN MEDICAL CENTER AT
DALLAS - 5323 HARRY HINES BLVD -
DALLAS, TX 75390-0860 75-6002868 STATE OF TX 116,225. 0. SUPPORT RESEARCH PROGRAM
CEDARS-SINAI MEDICAL CENTER

8700 BEVERLY BOULEVARD SUPPORT CHARITABLE
LOS ANGELES, CA 90048 95-1644600 501(C)(3) 113,309. 0. PROGRAMS
THE SCRIPPS RESEARCH INSTITUTE

10550 NORTH TORREY PINES ROAD SUPPORT CHARITABLE
LA JOLLA, CA 92037 33-0435954 501(C)(3) 107,741. 0. PROGRAMS
UNIVERSITY OF SOUTHERN CALIFORNIA

UNIVERSITY GARDENS UGB203 SUPPORT CHARITABLE
LOS ANGELES, CA 90089 95-1642394 501(C)(3) 107,458. 0. PROGRAMS
CHILDREN'S HOSPITAL CORPORATION

300 LONGWOOD AVENUE SUPPORT CHARITABLE
ROCHESTER AREA FOUNDATION

12 ELTON HILLS DRIVE NW SUPPORT CHARITABLE
THE REGENTS OF THE UNIVERSITY OF

COLORADO - 3100 MARINE ST RM 479
572 UCB - BOULDER, CO 80303 84-6000555 STATE OF CO 102,938. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 68
appraisal, other)
COLLIDER FOUNDATION
14 4TH ST SW SUPPORT CHARITABLE
BIOKIER INC
105 GREEN WILLOW CT
CHAPEL HILL, NC 27514-5211 26-3596494 - 99,761. 0. SUPPORT RESEARCH PROGRAM
THE UNIVERSITY OF TEXAS AT AUSTIN

110 INNER CAMPUS DRIVE
AUSTIN, TX 78705 74-6000203 STATE OF TX 97,624. 0. SUPPORT RESEARCH PROGRAM
SLOAN-KETTERING INSTITUTE FOR

CANCER RESEARCH - 1275 YORK AVENUE SUPPORT CHARITABLE
- NEW YORK, NY 10065 13-1624182 501(C)(3) 97,029. 0. PURPOSE
THE TOLEDO HOSPITAL

100 MADISON AVE SUPPORT CHARITABLE
TOLEDO, OH 43604 34-4428256 501(C)(3) 96,485. 0. PROGRAMS
UNIVERSITY OF PITTSBURGH
116 ATWOOD STREET SUITE 201 SUPPORT CHARITABLE
PITTSBURGH, PA 15260 25-0965591 501(C)(3) 96,370. 0. PROGRAMS
THORNE RESEARCH INC

PO BOX 2980
SUMMERVILLE, SC 29484 91-1248086 - 95,831. 0. SUPPORT RESEARCH PROGRAM
MCHS--LAKE CITY
500 WEST GRANT STREET SUPPORT CHARITABLE
LAKE CITY, MN 55041 41-1906820 501(C)(3) 95,798. 0. PROGRAMS
WELLSTAR HEALTH SYSTEM INC

793 SAWYER ROAD SUPPORT CHARITABLE
MARIETTA, GA 30062-2222 58-1649541 501(C)(3) 95,559. 0. PROGRAMS
232241
04-01-22 69
appraisal, other)
VIRGINIA HOSPITAL CENTER

1701 N GEORGE MASON DR
ARLINGTON, VA 22205 87-0807407 - 92,169. 0. SUPPORT RESEARCH PROGRAM
BOYS AND GIRLS CLUB OF ROCHESTER

1026 EAST CENTER STREET SUPPORT CHARITABLE
CRAIG AND FRANCES LINDNER CENTER

OF HOPE - 4075 OLD WESTERN ROW SUPPORT CHARITABLE
ROAD - MASON, OH 45040 13-4343743 501(C)(3) 89,685. 0. PROGRAMS
UNIVERSITY OF MIAMI
CORAL GABLES, FL 33124 59-0624458 501(C)(3) 89,556. 0. PROGRAMS
UNIVERSITY OF TEXAS MEDICAL BRANCH

AT GALVESTON - 301 UNIVERSTIY BLVD
- GALVESTON, TX 77555 74-6000949 STATE OF TX 84,122. 0. SUPPORT RESEARCH PROGRAM
BETH ISRAEL DEACONESS MEDICAL

CENTER - 330 BROOKLINE AVENUE - SUPPORT CHARITABLE
RONALD MCDONALD HOUSE OF ROCHESTER

MINNESOTA INC - 850 2ND ST SW - SUPPORT CHARITABLE
THE BOARD OF TRUSTEES OF THE
LELAND STANFORD JUNIOR UNIVERSITY
- 485 BROADWAY MAIL CODE 8838 - SUPPORT CHARITABLE
REDWOOD CITY, CA 94063 94-1156365 501(C)(3) 80,263. 0. PROGRAMS
LEGAL ASSISTANCE OF OLMSTED COUNTY

1700 NORTH BROADWAY NE RM/STE 124 SUPPORT CHARITABLE
232241
04-01-22 70
appraisal, other)
KAISER FOUNDATION HOSPITALS

ONE KAISER PLAZA 15L SUPPORT CHARITABLE
OAKLAND, CA 94612 94-1105628 501(C)(3) 79,365. 0. PROGRAMS
REDLINE EMERGENCY VOICE INC

101 E STATE AVE STE 2
PHOENIX, AZ 85020-4841 20-5934439 - 78,650. 0. SUPPORT RESEARCH PROGRAM
NEW YORK SOCIETY FOR THE RELIEF OF
THE RUPTURED AND CRIPPLED
MAINTAINING TH - 535 EAST 70TH ST SUPPORT CHARITABLE
STREET - NEW YORK, NY 10021 13-1624135 501(C)(3) 75,598. 0. PROGRAMS
CHANNEL ONE INC

131 35TH STREET SE SUPPORT CHARITABLE
AMERICAN ACADEMY OF ORTHOPAEDIC

SURGEONS - 9400 W HIGGINS ROAD NO SUPPORT CHARITABLE
500 - ROSEMONT, IL 60018-4976 36-2110592 501(C)(3) 74,547. 0. PROGRAMS
CASE WESTERN RESERVE UNIVERSITY

10900 EUCLID AVENUE SUPPORT CHARITABLE
CLEVELAND, OH 44106-7006 34-1018992 501(C)(3) 72,396. 0. PROGRAMS
THE FEINSTEIN INSTITUTE FOR

MEDICAL RESEARCH - 972 BRUSH SUPPORT CHARITABLE
HOLLOW ROAD - WESTBURY, NY 11590 11-2673595 501(C)(3) 70,645. 0. PROGRAMS
OLMSTED OUTREACH
ALTRU HEALTH SYSTEM

1200 S COLUMBIA RD SUPPORT CHARITABLE
GRAND FORKS, ND 58201-4036 45-0310462 501(C)(3) 69,052. 0. PROGRAMS
232241
04-01-22 71
appraisal, other)
OPTUM LABS TOPAZ INC

11000 OPTUM CIRCLE
EDEN PRAIRIE, MN 55344 46-1615964 - 67,000. 0. SUPPORT RESEARCH PROGRAM
UNIVERSITY OF MARYLAND
620 W LEXINGTON STREET
BALTIMORE, MD 21201 52-6002033 STATE OF MD 66,716. 0. SUPPORT RESEARCH PROGRAM
UNIVERSITY OF NORTH CAROLINA

HOSPITALS - 101 MANNING DRIVE -
CHAPEL HILL, NC 27514 56-1118388 STATE OF NC 66,201. 0. SUPPORT EXEMPT PURPOSE
UNIVERSITY OF CHICAGO
6054 S DREXEL AVENUE SUPPORT CHARITABLE
CHICAGO, IL 60637 36-2177139 501(C)(3) 64,843. 0. PROGRAMS
UNIVERSITY OF CONNECTICUT HEALTH

CENTER - 263 FARMINGTON AVE -
FARMINGTON, CT 06030-5335 52-1725543 STATE OF CT 64,730. 0. SUPPORT RESEARCH PROGRAM
SEATTLE CHILDREN'S HOSPITAL

PO BOX 5371 MS RC-507 SUPPORT CHARITABLE
SEATTLE, WA 98145 91-0564748 501(C)(3) 62,380. 0. PROGRAMS
BUCK INSTITUTE FOR RESEARCH ON

AGING - 8001 REDWOOD BOULEVARD - SUPPORT CHARITABLE
NOVATO, CA 94945 94-3030609 501(C)(3) 62,036. 0. PROGRAMS
ARIZONA BOARD OF REGENTS
UNIVERSITY OF ARIZONA - 888 NORTH
EUCLID AVENUE ROOM 510 - TUCSON, MEDICAL
AZ 85719 74-2652689 STATE OF AZ 61,500. 33,090.FMV SUPPLIES SUPPORT RESEARCH PROGRAM
PORTLAND STATE UNIVERSITY

PO BOX 751
PORTLAND, OR 97207 36-4776757 STATE OF OR 60,000. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 72
appraisal, other)
OLMSTED COUNTY
151 4TH STREET SE
ROCHESTER, MN 55904 41-6005859 CTY OF OLMSTED 60,000. 0. SUPPORT RESEARCH PROGRAM
TRUSTEES OF BOSTON UNIVERSITY

881 COMMONWEALTH AVENUE SUPPORT CHARITABLE
BOSTON, MA 02215-1303 04-2103547 501(C)(3) 59,541. 0. PROGRAMS
GEORGE MASON UNIVERSITY

4400 UNIVERSITY DRIVE
FAIRFAX, VA 22030 54-0836354 STATE OF VA 58,592. 0. SUPPORT RESEARCH PROGRAM
FRED HUTCHINSON CANCER RESEARCH

CENTER - 1100 FAIRVIEW AVENUE SUPPORT CHARITABLE
SOUTH - SEATTLE, WA 98109 23-7156071 501(C)(3) 57,472. 0. PROGRAMS
MAYO CLINIC FLORIDA

4500 SAN PABLO ROAD SUPPORT CHARITABLE
JACKSONVILLE, FL 32224 59-0714831 501(C)(3) 55,547. 0. PROGRAMS
BANNER HEALTH
2901 N CENTRAL AVE SUITE 160 SUPPORT CHARITABLE
ARCHINOETICS LLC
700 BISHOP STREET
HONOLULU, HI 96813 20-1347328 - 54,067. 0. SUPPORT RESEARCH PROGRAM
MCHS--AUSTIN FOUNDATION
1000 FIRST DRIVE N.W. SUPPORT CHARITABLE
AUSTIN, MN 55912 30-0107471 501(C)(3) 53,428. 0. PROGRAMS
POSSABILITIES OF SOUTHERN
MINNESOTA - 1808 3RD AVENUE SE - SUPPORT CHARITABLE
232241
04-01-22 73
appraisal, other)
TUFTS MEDICAL CENTER INC

800 WASHINTON STREET BOX 468 SUPPORT CHARITABLE
UNIVERSITY OF SOUTH FLORIDA

4202 E FOWLER AVE
TAMPA, FL 33620 59-3102112 STATE OF FL 51,167. 0. SUPPORT RESEARCH PROGRAM
ELDER NETWORK
1130 1/2 7TH ST NW SUITE 205 SUPPORT CHARITABLE
FRIENDS OF OXBOW
GROWING HOME
2100 CAMPUS DRIVE SUPPORT CHARITABLE
MINNESOTA CHILDRENS MUSEUM

10 WEST 7TH STREET SUPPORT CHARITABLE
ST. PAUL, MN 55102 41-1354181 501(C)(3) 50,000. 0. PROGRAMS
SCIENCE MUSEUM OF MINNESOTA

120 W KELLOGG BLVD SUPPORT CHARITABLE
ST. PAUL, MN 55102 41-0706172 501(C)(3) 50,000. 0. PROGRAMS
EISENHOWER MEDICAL CENTER

39000 BOB HOPE DRIVE SUPPORT CHARITABLE
RANCHO MIRAGE, CA 92270 95-6130458 501(C)(3) 50,000. 0. PROGRAMS
PRESIDENT AND FELLOWS OF HARVARD

COLLEGE - 1033 MASSACHUSETTS AVE SUPPORT CHARITABLE
3RD FL - CAMBRIDGE, MA 02138 04-2103580 501(C)(3) 49,890. 0. PROGRAMS
232241
04-01-22 74
appraisal, other)
BENCHMARK ELECTRONICS INC

56 SOUTH ROCKFORD DRIVE
TEMPE, AZ 85281 74-2211011 - 48,658. 0. SUPPORT RESEARCH PROGRAM
RUTGERS THE STATE UNIVERSITY OF

NEW JERSEY - 303 COOPER STREET -
CAMDEN, NJ 08102 22-6001086 STATE OF NJ 45,805. 0. SUPPORT RESEARCH PROGRAM
JEREMIAH PROGRAM
615 FIRST AVENUE NE NO 210 SUPPORT CHARITABLE
UNIVERSITY OF PUERTO RICO MEDICAL

SCIENCES CAMPUS - PO BOX 365067 -
SAN JUAN, PR 00936-5067 66-0433762 COMMONWEALTH OF 42,517. 0. SUPPORT RESEARCH PROGRAM
CLOTHIER DESIGN SOURCE LLC

2408 TERRITORIAL RD
SAINT PAUL, MN 55114-1506 27-1696142 - 41,953. 0. SUPPORT RESEARCH PROGRAM
ABILITY BUILDING CENTER, INC.

1911 14TH STREET NW SUPPORT CHARITABLE
CLEVELAND CLINIC FLORIDA (A
NONPROFIT CORPORATION) - 2950
CLEVELAND CLINIC BLVD - WESTON, FL SUPPORT CHARITABLE
33331-3609 65-0003177 501(C)(3) 41,325. 0. PROGRAMS
DIVERSITY COUNCIL
1130-1/2 7TH ST NW STE 204 SUPPORT CHARITABLE
EXERCISABILITIES INC
2530 N BROADWAY AVE SUPPORT CHARITABLE
232241
04-01-22 75
appraisal, other)
WOMEN'S SHELTER INC

THE LUNDQUIST INSTITUTE

1124 W CARSON ST MRL BLDG SUPPORT CHARITABLE
TORRANCE, CA 90502 95-2138184 501(C)(3) 39,630. 0. PROGRAMS
MONTANA STATE UNIVERSITY

216 MONTANA HALL
BOZEMAN, MT 59717-2470 81-6010045 STATE OF MT 38,573. 0. SUPPORT RESEARCH PROGRAM
GEORGETOWN UNIVERSITY
37TH AND O STREETS NW SUPPORT CHARITABLE
WASHINGTON, DC 20057 53-0196603 501(C)(3) 38,077. 0. PROGRAMS
SOMALI AMERICAN SOCIAL SERVICE

ASSOCIATION - 1700 N BROADWAY SUPPORT CHARITABLE
SUITE 152A - ROCHESTER, MN 55906 46-1751962 501(C)(3) 38,000. 0. PURPOSE
CHARLOTTE-MECKLENBURG HOSPITAL
AUTHORITY - 1000 BLYTHE BLDV -
CHARLOTTE, NC 28203 56-0529945 STATE OF NC 37,313. 0. SUPPORT RESEARCH PROGRAM
TRUSTEES OF TUFTS COLLEGE

169 HOLLAND STREET ATTN TAX DEPT SUPPORT CHARITABLE
SOMERVILLE, MA 02144 04-2103634 501(C)(3) 37,086. 0. PROGRAMS
SPORTS MENTORSHIP ACADEMY

3270 19TH ST NW SUITE 208 SUPPORT CHARITABLE
ORTHOCAROLINA RESEARCH INSTITUTE

INC - 2001 VAIL AVENUE NO 300 - SUPPORT CHARITABLE
CHARLOTTE, NC 28207 01-0648145 501(C)(3) 35,882. 0. PROGRAMS
232241
04-01-22 76
appraisal, other)
UNIVERSITY OF MISSISSIPPI MEDICAL

CENTER HOSPITAL - 2500 NORTH STATE
STREET - JACKSON, MS 39216 64-6008520 STATE OF MS 35,770. 0. SUPPORT RESEARCH PROGRAM
ROCHESTER ART CENTER

40 CIVIC CENTER DR SE SUPPORT CHARITABLE
IOWA STATE UNIVERSITY

394 TOWN ENGINEERING BUILDING
AMES, IA 50011 42-6004224 STATE OF IA 34,801. 0. SUPPORT EXEMPT PURPOSE
HEBREW REHABILITATION CENTER

1200 CENTRE STREET SUPPORT CHARITABLE
UNIVERSITY OF ARKANSAS FOR MEDICAL

SCIENCES - 4301 WEST MARKHAM #812
- LITTLE ROCK, AR 72201 71-6046242 STATE OF AR 33,897. 0. SUPPORT RESEARCH PROGRAM
RECOVERY IS HAPPENING
25 16TH STREET NE SUPPORT CHARITABLE
MASSACHUSETTS INSTITUTE OF
TECHNOLOGY - 77 MASSACHUSETTS
AVENUE NE49-3142 - CAMBRIDGE, MA SUPPORT CHARITABLE
02139 04-2103594 501(C)(3) 33,518. 0. PROGRAMS
RUSH UNIVERSITY MEDICAL CENTER

1700 WEST VAN BUREN STREET 265 SUPPORT CHARITABLE
CHICAGO, IL 60612 36-2174823 501(C)(3) 32,406. 0. PROGRAMS
HMH HOSPITALS CORPORATION

1350 CAMPUS PARKWAY SUPPORT CHARITABLE
NEPTUNE, NJ 07753 22-1487576 501(C)(3) 31,500. 0. PROGRAMS
232241
04-01-22 77
appraisal, other)
FAMILY PROMISE ROCHESTER

913 1ST STREET NW SUPPORT CHARITABLE
SOUTHEAST MINNESOTA IMMUNIZATION

CONNECTION - PO BOX 6660 - SUPPORT CHARITABLE
AMERICAN CANCER SOCIETY INC.

250 WILLIAMS STREET NW NO 400 SUPPORT CHARITABLE
ATLANTA, GA 30303 13-1788491 501(C)(3) 30,000. 0. PROGRAMS
BOARD OF REGENTS OF THE UNIVERSITY
OF NEBRASKA - 151 PREM S PAUL
RESEARCH CENTER - LINCOLN, NE
68583 47-0049123 STATE OF NE 29,390. 0. SUPPORT RESEARCH PROGRAM
GIFT OF LIFE INC

705 2ND STREET SW SUPPORT CHARITABLE
GIRL SCOUTS OF MN AND WI RIVER

VALLEYS INC - 400 ROBERT STREET SUPPORT CHARITABLE
SOUTH - ST. PAUL, MN 55107 41-0693910 501(C)(3) 28,000. 0. PROGRAMS
MEMORIAL HOSPITAL FOR CANCER AND

ALLIED DISEASES - 1275 YORK AVENUE SUPPORT CHARITABLE
- NEW YORK, NY 10065 13-1624082 501(C)(3) 27,652. 0. PROGRAMS
ALASKA NATIVE TRIBAL HEALTH

CONSORTIUM - 4000 AMBASSADOR DRIVE SUPPORT CHARITABLE
- ANCHORAGE, AK 99508 92-0162721 501(C)(3) 27,569. 0. PROGRAMS
SOUTHERN MINNESOTA INITIATIVE

FOUNDATION - 525 FLORENCE AVE - SUPPORT CHARITABLE
OWATONNA, MN 55060 36-3454285 501(C)(3) 25,000. 0. PURPOSE
232241
04-01-22 78
appraisal, other)
CITY OF ROCHESTER
201 4TH STREET SE
ROCHESTER, MN 55904 41-6005494 CITY OF ROCHESTE 25,000. 0. SUPPORT RESEARCH PROGRAM
DYSLEXIA INSTITUTE OF MN INC

2010 SCOTT RD NW SUPPORT CHARITABLE
ST VINCENT HOSPITAL OF THE
HOSPITAL SISTERS OF THE THIRD
ORDER OF ST FRANCI - 835 S VAN SUPPORT CHARITABLE
BUREN - GREEN BAY, WI 54301 39-0817529 501(C)(3) 24,805. 0. PROGRAMS
ONCOLOGY HEMATOLOGY ASSOCIATES OF

CENTRAL ILLINOIS PC - 8940 NORTH
WOOD SAGE ROAD - PEORIA, IL 61615 37-1331017 - 23,312. 0. SUPPORT RESEARCH PROGRAM
THE CLEVELAND CLINIC FOUNDATION

6801 BRECKSVILLE RD RK1-85 SUPPORT CHARITABLE
INDEPENDENCE, OH 44131 34-0714585 501(C)(3) 23,079. 0. PROGRAMS
MINNESOTA HEALTHSOLUTIONS
CORPORATION - 861 E HENNEPIN AVE
STE 440 - MINNEAPOLIS, MN 55414 20-4428357 - 22,755. 0. SUPPORT RESEARCH PROGRAM
THE UNIVERSITY CORPORATION

18111 NORDHOFF STREET SUPPORT CHARITABLE
NORTHRIDGE, CA 91330-8310 95-1992732 501(C)(3) 21,674. 0. PROGRAMS
BAYLOR RESEARCH INSTITUTE

301 N WASHINGTON AVENUE SUPPORT CHARITABLE
DALLAS, TX 75246 75-1921898 501(C)(3) 21,598. 0. PROGRAMS
INTERMOUNTAIN HEALTH CARE INC

36 S STATE STREET SUITE 2200 SUPPORT CHARITABLE
SALT LAKE CITY, UT 84111 87-0269232 501(C)(3) 20,750. 0. PROGRAMS
232241
04-01-22 79
appraisal, other)
MYALGIC ENCEPHALOMYELITIS ACTION
NETWORK INC - 1217 WILSHIRE
BOULEVARD NO 3639 - SANTA MONICA, SUPPORT CHARITABLE
CA 90403 47-4011296 501(C)(3) 20,350. 0. PROGRAMS
UNIVERSITY OF CALIFORNIA IRVINE

160 ALDRICH HALL
IRVINE, CA 92697 95-2226406 STATE OF CA 20,000. 0. SUPPORT RESEARCH PROGRAM
ROCHESTER SPORTS FOUNDATION

30 CIVIC CENTER DRIVE SE
ROCHESTER, MN 55904 84-2551350 501(C)(3) 20,000. 0. SUPPORT RESEARCH PROGRAM
CHILDRENS DENTAL HEALTH SERVICES

903 WEST CENTER STREET SUPPORT CHARITABLE
GAMEHAVEN COUNCIL INC BOY SCOUTS

OF AMERICA - 607 E CENTER ST - SUPPORT CHARITABLE
CERVICAL SPINE RESEARCH SOCIETY

555 E WELLS STREET SUPPORT CHARITABLE
MILWAUKEE, WI 53202 52-1231718 501(C)(3) 20,000. 0. PURPOSE
BAYLOR COLLEGE OF MEDICINE

ONE BAYLOR PLAZA BCM 200 SUPPORT CHARITABLE
HOUSTON, TX 77030-3498 74-1613878 501(C)(3) 19,873. 0. PROGRAMS
UNIVERSITY OF MASSACHUSETTS LOWELL

600 SUFFOLK STREET
LOWELL, MA 01854 04-3167352 STATE OF MA 19,579. 0. SUPPORT RESEARCH PROGRAM
SOFI RESEARCH LLC

499 E HAMPDEN AVE
ENGLEWOOD, CO 80113 82-1682239 - 18,730. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 80
appraisal, other)
SANFORD RESEARCH
PO BOX 5039 RTE 5218 SUPPORT CHARITABLE
SIOUX FALLS, SD 57117 46-0450378 501(C)(3) 18,516. 0. PROGRAMS
THE ADMINISTRATORS OF THE TULANE

EDUCATIONAL FUND - 6823 ST CHARLES SUPPORT CHARITABLE
AVENUE - NEW ORLEANS, LA 70118 72-0423889 501(C)(3) 18,123. 0. PROGRAMS
THE CARLE FOUNDATION HOSPITAL

611 WEST PARK SUPPORT CHARITABLE
URBANA, IL 61801 37-1119538 501(C)(3) 17,977. 0. PROGRAMS
ACHLA ALIANZA CHICANA HISP LAT

AMER ALLIANCE - 1504 13TH AVE NE - SUPPORT CHARITABLE
WAYNE STATE UNIVERSITY

5057 WOODWARD 13TH FLOOR
DETROIT, MI 48202 38-6028429 STATE OF MI 15,547. 0. SUPPORT RESEARCH PROGRAM
MARSHFIELD CLINIC HEALTH SYSTEM

INC - 1000 N OAK AVENUE - SUPPORT CHARITABLE
MARSHFIELD, WI 54449 46-1495343 501(C)(3) 15,381. 0. PROGRAMS
SIOUXLAND REGIONAL CANCER CENTER

SIOUX CITY, IA 51102 42-1411233 501(C)(3) 15,250. 0. PROGRAMS
DIGNITY HEALTH
185 BERRY STREET SUITE 300 SUPPORT CHARITABLE
SAN FRANCISCO, CA 94107 94-1196203 501(C)(3) 15,165. 0. PROGRAMS
UNIVERSITY OF NOTRE DAME DU LAC

CONTROLLERS OFFICE 724 GRACE HALL SUPPORT CHARITABLE
NOTRE DAME, IN 46556 35-0868188 501(C)(3) 15,018. 0. PROGRAMS
232241
04-01-22 81
appraisal, other)
USAGAINSTALZHEIMER'S
1101 K STREET NW NO 400 SUPPORT CHARITABLE
ASHLEY FOR THE ARTS

ONE ASHLEY WAY SUPPORT CHARITABLE
ARCADIA, WI 54612 46-2152808 501(C)(3) 15,000. 0. PURPOSE
MIRACLE FIELD OF ROCHESTER

3008 WELLNER DRIVE NE SUPPORT CHARITABLE
NEUROLOGICAL RECOVERY HOUSE

1919 23 1/2 ST SE SUPPORT CHARITABLE
ROCHESTER REPERTORY
103 7TH STREET NE SUPPORT CHARITABLE
FRONT AND CENTER MINISTRIES INC

111 CENTER AVE SUPPORT CHARITABLE
EYOTA, MN 55934 85-4288423 501(C)(3) 15,000. 0. PURPOSE
OLMSTED COUNTY HISTORICAL SOCIETY

1195 WEST CIRCLE DRIVE SW SUPPORT CHARITABLE
ROCHESTER SYMPHONY ORCHESTRA &

CHORALE - 1530 GREENVIEW DR SW 120 SUPPORT CHARITABLE
- ROCHESTER, MN 55902 41-1764434 501(C)(3) 15,000. 0. PROGRAMS
ROCHESTER SWIM CLUB ORCAS

232241
04-01-22 82
appraisal, other)
CONSUMERS FOR DENTAL CHOICE INC

316 F STREET NE STE 212 SUPPORT CHARITABLE
OKLAHOMA HEART RESEARCH AND
EDUCATION FOUNDATION INC - 1265 S
UTICA AVE STE 300 - TULSA, OK SUPPORT CHARITABLE
74104 73-1432360 501(C)(3) 13,750. 0. PROGRAMS
NATIONWIDE CHILDREN'S HOSPITAL

700 CHILDREN'S DRIVE SUPPORT CHARITABLE
COLUMBUS, OH 43205 31-4379441 501(C)(3) 13,379. 0. PROGRAMS
OKLAHOMA MEDICAL RESEARCH

FOUNDATION - 825 NE 13TH STREET - SUPPORT CHARITABLE
OKLAHOMA CITY, OK 73104 73-0580274 501(C)(3) 13,197. 0. PROGRAMS
CANCER CENTER OF KANSAS PA

818 N EMPORIA ST STE 403
WICHITA, KS 67214-3728 48-1181579 - 12,912. 0. SUPPORT RESEARCH PROGRAM
BLACK DATA PROCESSING ASSOCIATES

SOUTHERN MN CHAPTER - PO BOX 6981 SUPPORT CHARITABLE
- ROCHESTER, MN 55901 41-1929150 501(C)(3) 12,500. 0. PROGRAMS
MAYO CLINIC HOSPITAL-- ROCHESTER

200 FIRST STREET S.W. SUPPORT CHARITABLE
SUTTER WEST BAY HOSPITALS

2200 RIVER PLAZA DR SUPPORT CHARITABLE
SACRAMENTO, CA 95833 94-0562680 501(C)(3) 11,000. 0. PROGRAMS
LUMBAR SPINE RESEARCH SOCIETY INC

1685 HIGHLAND AVE SUPPORT CHARITABLE
MADISON, WI 53705 26-2160175 501(C)(3) 10,500. 0. PURPOSE
232241
04-01-22 83
appraisal, other)
HENNEPIN THEATRE TRUST

900 HENNEPIN AVE SUPPORT CHARITABLE
MINNEAPOLIS, MN 55403 41-2017278 501(C)(3) 10,000. 0. PURPOSE
BOLDER OPTIONS
2100 STEVENS AVE S SUPPORT CHARITABLE
GIRLS ON THE RUN TWIN CITIES INC

3433 BROADWAY ST NE NO 430 SUPPORT CHARITABLE
SERVEMINNESOTA
120 SOUTH 6TH STREET NO 2260 SUPPORT CHARITABLE
IGNITE AFTERSCHOOL
1400 VAN BUREN ST NE SUPPORT CHARITABLE
NORTHLAND COMMUNITY AND TECHNICAL

COLLEGE FOUNDATION - 1101 HWY ONE SUPPORT CHARITABLE
EAST - THIEF RIVER FALLS, MN 56701 41-1287038 501(C)(3) 10,000. 0. PURPOSE
MINNESOTA TEEN CHALLENGE INC

740 E 24TH STREET SUPPORT CHARITABLE
MINNESOTA ZOO FOUNDATION

13000 ZOO BOULEVARD SUPPORT CHARITABLE
APPLE VALLEY, MN 55124 51-0147653 501(C)(3) 10,000. 0. PURPOSE
ST JOSEPH MERCY HOSPITAL

PO BOX 223087
PITTSBURGH, PA 15251 38-3175878 - 9,177. 0. SUPPORT RESEARCH PROGRAM
232241
04-01-22 84
appraisal, other)
SOUTHEASTERN MINNESOTA YOUTH

ORCHESTRA INC - 1001 14TH ST NW SUPPORT CHARITABLE
SUITE 450 - ROCHESTER, MN 55901 41-1427785 501(C)(3) 9,000. 0. PROGRAMS
THE CENTER CLINIC INC

14 WEST MAIN ST SUPPORT CHARITABLE
DODGE CENTER, MN 55927 20-0756495 501(C)(3) 8,000. 0. PURPOSE
MINNESOTA ASSISTANCE COUNCIL FOR

VETERANS - 1000 UNIVERSITY AVENUE SUPPORT CHARITABLE
WEST NO 10 - SAINT PAUL, MN 55104 41-1694717 501(C)(3) 8,000. 0. PROGRAMS
CHARTERHOUSE, INC.
200 FIRST STREET S.W. SUPPORT CHARITABLE
SAINT PAUL CHAMBER ORCHESTRA

SOCIETY - 408 ST PETER STREET 3RD SUPPORT CHARITABLE
FL - ST PAUL, MN 55102 41-0829498 501(C)(3) 7,500. 0. PURPOSE
ST ELIZABETH MEDICAL CENTER INC

ONE MEDICAL VILLAGE DRIVE SUPPORT CHARITABLE
EDGEWOOD, KY 41017 61-0445850 501(C)(3) 6,775. 0. PROGRAMS
MOREHOUSE SCHOOL OF MEDICINE

720 WESTVIEW DRIVE SW SUPPORT CHARITABLE
ATLANTA, GA 30310 58-1438873 501(C)(3) 6,758. 0. PROGRAMS
HIAWATHA HOMES INC

1820 VALKYRIE DR NW SUPPORT CHARITABLE
ST CLOUD HOSPITAL
1406 SITH AVENUE NORTH SUPPORT CHARITABLE
ST. CLOUD, MN 56303 41-0695596 501(C)(3) 6,336. 0. PROGRAMS
232241
04-01-22 85
appraisal, other)
MARY HITCHCOCK MEMORIAL HOSPITAL

ONE MEDICAL CENTER DRIVE SUPPORT CHARITABLE
LEBANON, NH 03756 02-0222140 501(C)(3) 6,192. 0. PROGRAMS
ROCHESTER OLMSTED COUNTY SAFETY

COUNCIL - 101 SE 4 STREET -
ROCHESTER, MN 55904 41-1389501 501(C)(3) 6,000. 0. SUPPORT RESEARCH PROGRAM
THE RECTOR AND VISITORS OF THE
UNIVERSITY OF VIRGINIA - 1001 N
EMMET STREET - CHARLOTTESVILLE, VA
22903 54-6001796 STATE OF VA 5,060. 0. SUPPORT RESEARCH PROGRAM
MATTER
7005 OXFORD STREET MEDICAL SUPPORT CHARITABLE
ST. LOUIS PARK, MN 55426 37-1441658 501(C)(3) 0. 427,315.FMV SUPPLIES PROGRAMS
MEDICAL MISSIONS
2655 NORTHWINDS PKWY MEDICAL SUPPORT CHARITABLE
ALPHARETTA, GA 30009 27-1917502 501(C)(3) 0. 52,865.FMV SUPPLIES PROGRAMS
232241
04-01-22 86
Schedule I (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part III Grants and Other Assistance to Domestic Individuals. Complete if the organization answered "Yes" on Form 990, Part IV, line 22.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Number of (c) Amount of (d) Amount of non- (e) Method of valuation (f) Description of noncash assistance
recipients cash grant cash assistance (book, FMV, appraisal, other)
SCHOLARSHIPS 1074 16,281,182. 0.
MEDICAL STUDENT STIPENDS 688 12,112,516. 0.
CHARITABLE SUPPORT OF INDIVIDUALS 42 103,802. 0.
Part IV Supplemental Information. Provide the information required in Part I, line 2; Part III, column (b); and any other additional information.
PART I, LINE 2:
AS A PRIVATE TRUST FOR THE PUBLIC GOOD, MAYO IS DEDICATED TO GIVING BACK TO
THE COMMUNITIES IN WHICH ITS EMPLOYEES LIVE AND WORK. MAYO INVESTS
RESOURCES RESPONSIBLY TO PRODUCE THE BEST OUTCOMES FOR PATIENT CARE,
EDUCATION, RESEARCH, COMMUNITY ENRICHMENT AND SUSTAINABILITY. GRANT
APPLICATIONS ARE REVIEWED AND PRIORITIZED IN HOW THEY:
-ADDRESS SIGNIFICANT AND EMERGENT COMMUNITY NEEDS
-ALIGN WITH MAYO'S MISSION
-IMPROVE HEALTH OF INDIVIDUALS IN THE COMMUNITY

232102 10-31-22 87 Schedule I (Form 990) 2022
-DEMONSTRATE PARTNERSHIP AND COLLABORATION BUILDING
-ENABLE LONG TERM CAPACITY BUILDING AND SUSTAINABILITY
-REDUCE DISPARITIES AND INEQUITIES RELATED TO ACCESS TO HEALTH AND WELLNESS
MONITORING OF GRANTS GIVEN IS DEPENDENT ON TYPE. LARGER MULTI-YEAR AND
CAPITAL GRANTS ARE MONITORED FOR ACHIEVEMENT OF STATED GOALS WITHIN THE
GRANT AGREEMENT. SINGLE-YEAR OPERATIONAL AND PROGRAMMATIC GRANTS ARE NOT
MONITORED AFTER THE FUNDS HAVE BEEN DISBURSED; HOWEVER, ADDITIONAL FUNDING
REQUESTS ARE CONSIDERED BASED ON USE AND OUTCOMES OF PREVIOUSLY AWARDED
GRANTS.
FEDERAL AWARDS THAT ARE SUBCONTRACTED TO INDIVIDUALS AND OTHER
ORGANIZATIONS ARE MONITORED BY MAYO AS PRESCRIBED IN TITLE 2 U.S. CODE OF
FEDERAL REGULATIONS PART 200, UNIFORM ADMINISTRATIVE REQUIREMENTS, COST
PRINCIPLES, AND AUDIT REQUIREMENTS FOR FEDERAL AWARDS (UNIFORM GUIDANCE),
SUBPART D-SUBRECIPIENT MONITORING AND MANAGEMENT 200.331 REQUIREMENTS FOR
PASS-THROUGH ENTITIES.
SHORT-TERM FINANCIAL ASSISTANCE AND SUPPORT IS PROVIDED TO EMPLOYEES AND
INDIVIDUALS EXPERIENCING TEMPORARY HARDSHIPS. GRANTS ARE PROVIDED BASED ON
A PROVEN NEED AND ARE NOT MONITORED.
MEDICAL STUDENT STIPENDS ARE PAID TO THE STUDENTS OF THE MAYO CLINIC
COLLEGE OF MEDICINE AND SCIENCE TO HELP OFFSET THE COST OF THE STUDENT'S
LIVING EXPENSES AND ARE NOT MONITORED.
MERIT-BASED AND NEEDS-BASED SCHOLARSHIPS AND GRANTS ARE AWARDED TO
INDIVIDUALS PURSUING A DEGREE IN A HEALTHCARE FIELD AND ARE CONTINGENT UPON

232291
04-01-22
88
ON-GOING SATISFACTORY ACADEMIC PROGRESS.

232291
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89
SCHEDULE J Compensation Information OMB No. 1545-0047
(Form 990) For certain Officers, Directors, Trustees, Key Employees, and Highest
Compensated Employees
2022
Part I Questions Regarding Compensation
Yes No
1a Check the appropriate box(es) if the organization provided any of the following to or for a person listed on Form 990,
Part VII, Section A, line 1a. Complete Part III to provide any relevant information regarding these items.
X First-class or charter travel Housing allowance or residence for personal use
X Travel for companions Payments for business use of personal residence
X Tax indemnification and gross-up payments Health or social club dues or initiation fees
Discretionary spending account X Personal services (such as maid, chauffeur, chef)
b If any of the boxes on line 1a are checked, did the organization follow a written policy regarding payment or
reimbursement or provision of all of the expenses described above? If "No," complete Part III to explain ~~~~~~~~~~~ 1b X
2 Did the organization require substantiation prior to reimbursing or allowing expenses incurred by all directors,
trustees, and officers, including the CEO/Executive Director, regarding the items checked on line 1a? ~~~~~~~~~~~~ 2 X
3 Indicate which, if any, of the following the organization used to establish the compensation of the organization's
CEO/Executive Director. Check all that apply. Do not check any boxes for methods used by a related organization to
establish compensation of the CEO/Executive Director, but explain in Part III.
X Compensation committee Written employment contract
X Independent compensation consultant X Compensation survey or study
X Form 990 of other organizations X Approval by the board or compensation committee
4 During the year, did any person listed on Form 990, Part VII, Section A, line 1a, with respect to the filing
organization or a related organization:
a Receive a severance payment or change-of-control payment? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4a X
b Participate in or receive payment from a supplemental nonqualified retirement plan? ~~~~~~~~~~~~~~~~~~~~ 4b X
c Participate in or receive payment from an equity-based compensation arrangement? ~~~~~~~~~~~~~~~~~~~~ 4c X
If "Yes" to any of lines 4a-c, list the persons and provide the applicable amounts for each item in Part III.
Only section 501(c)(3), 501(c)(4), and 501(c)(29) organizations must complete lines 5-9.
5 For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any compensation
contingent on the revenues of:
a The organization? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5a X
b Any related organization? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5b X
If "Yes" on line 5a or 5b, describe in Part III.
6 For persons listed on Form 990, Part VII, Section A, line 1a, did the organization pay or accrue any compensation
contingent on the net earnings of:
a The organization? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6a X
b Any related organization? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6b X
If "Yes" on line 6a or 6b, describe in Part III.
7 For persons listed on Form 990, Part VII, Section A, line 1a, did the organization provide any nonfixed payments
not described on lines 5 and 6? If "Yes," describe in Part III ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7 X
8 Were any amounts reported on Form 990, Part VII, paid or accrued pursuant to a contract that was subject to the
initial contract exception described in Regulations section 53.4958-4(a)(3)? If "Yes," describe in Part III ~~~~~~~~~~~ 8 X
9 If "Yes" on line 8, did the organization also follow the rebuttable presumption procedure described in
Regulations section 53.4958-6(c)? ••••••••••••••••••••••••••••••••••••••••••••• 9
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990. Schedule J (Form 990) 2022
232111 10-18-22
90
Schedule J (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part II Officers, Directors, Trustees, Key Employees, and Highest Compensated Employees. Use duplicate copies if additional space is needed.
For each individual whose compensation must be reported on Schedule J, report compensation from the organization on row (i) and from related organizations, described in the instructions, on row (ii).
Do not list any individuals that aren't listed on Form 990, Part VII.
Note: The sum of columns (B)(i)-(iii) for each listed individual must equal the total amount of Form 990, Part VII, Section A, line 1a, applicable column (D) and (E) amounts for that individual.
(B) Breakdown of W-2 and/or 1099-MISC and/or 1099-NEC (C) Retirement and (D) Nontaxable (E) Total of columns (F) Compensation
compensation other deferred benefits (B)(i)-(D) in column (B)
(A) Name and Title (i) Base (ii) Bonus & (iii) Other compensation reported as deferred
compensation incentive reportable on prior Form 990
compensation compensation
FARRUGIA M.D., GIANRICO (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE/PRESIDENT/CEO (ii) 2,894,309. 0. 741,782. 45,200. 39,051. 3,720,342. 0.
GRAY M.D., RICHARD J. (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE/VP (ii) 1,662,172. 0. 337,252. 38,938. 34,336. 2,072,698. 0.
THIELEN M.D., KENT R. (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE/VP (ii) 1,666,603. 0. 340,069. 46,442. 35,900. 2,089,014. 0.
GORMAN, PAUL A. (i) 0. 0. 0. 0. 0. 0. 0.
TREASURER (ii) 831,217. 737,643. 146,196. 50,632. 36,060. 1,801,748. 0.
ZORN, CHRISTINA K. (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE/VP (ii) 1,352,248. 0. 178,426. 35,962. 35,848. 1,602,484. 0.
DAHLEN, DENNIS E. (i) 0. 0. 0. 0. 0. 0. 0.
CFO (ii) 1,326,278. 0. 155,124. 56,527. 35,947. 1,573,876. 0.
KRAUSS M.D., WILLIAM E. (i) 1,206,203. 0. 256,797. 48,573. 27,684. 1,539,257. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
LANZINO M.D., GIUSEPPE (i) 1,201,063. 0. 251,568. 44,008. 34,455. 1,531,094. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
MURPHY, JOSHUA B. (i) 0. 0. 0. 0. 0. 0. 0.
SECY (ii) 1,162,409. 0. 239,637. 45,082. 38,853. 1,485,981. 0.
PICHELMANN M.D., MARK A. (i) 1,218,043. 0. 187,775. 32,347. 32,614. 1,470,779. 0.
CHAIR-NWWI NEUROSURGERY (ii) 0. 0. 0. 0. 0. 0. 0.
WILLIAMS M.D., AMY W. (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE (ii) 1,209,322. 0. 188,052. 63,336. 8,923. 1,469,633. 0.
MARSH M.D., W. RICHARD (i) 1,123,766. 0. 254,645. 12,200. 27,427. 1,418,038. 0.
DIR-SPINE CENTER (ii) 0. 0. 0. 0. 0. 0. 0.
CLARKE M.D., MICHELLE J. (i) 1,202,943. 0. 124,997. 29,483. 24,103. 1,381,526. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
GORES M.D., GREGORY J. (i) 1,074,182. 0. 227,041. 12,200. 27,774. 1,341,197. 0.
EXECUTIVE DEAN OF RESEARCH (ii) 0. 0. 0. 0. 0. 0. 0.
WILLIAMSON, MARY J. (i) 926,412. 0. 170,168. 38,629. 39,619. 1,174,828. 0.
CAO-MCS (ii) 0. 0. 0. 0. 0. 0. 0.
OTLEY M.D., CLARK C. (i) 881,648. 0. 196,362. 44,702. 37,216. 1,159,928. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
Schedule J (Form 990) 2022
232112 10-18-22 91
AMMASH M.D., NASER M. (i) 0. 0. 0. 0. 0. 0. 0.
FORMER KEY EMPLOYEE (ii) 413,941. 0. 622,121. 52,861. 22,737. 1,111,660. 0.
MENKOSKY, PAULA E. (i) 0. 0. 0. 0. 0. 0. 0.
ASST SECY (ii) 839,482. 20,000. 151,966. 48,196. 33,348. 1,092,992. 0.
HARPER JR., M.D., CHARLES M. (i) 673,709. 0. 369,151. 12,200. 26,434. 1,081,494. 0.
TRUSTEE (ii) 0. 0. 0. 0. 0. 0. 0.
PAGNANO M.D., MARK W. (i) 785,193. 0. 138,176. 45,724. 35,944. 1,005,037. 0.
CHAIR-ORTHOPEDICS (ii) 0. 0. 0. 0. 0. 0. 0.
SHAH M.D., VIJAY (i) 763,209. 0. 167,510. 41,360. 32,176. 1,004,255. 0.
CHAIR-ROCH INTERN MED (ii) 0. 0. 0. 0. 0. 0. 0.
CALLSTROM M.D., MATTHEW R. (i) 758,030. 0. 162,032. 53,268. 25,710. 999,040. 0.
TRUSTEE (ii) 0. 0. 0. 0. 0. 0. 0.
RIHAL M.D., CHARANJIT S. (i) 723,645. 0. 177,815. 51,299. 33,403. 986,162. 0.
TRUSTEE (ii) 0. 0. 0. 0. 0. 0. 0.
MORICE M.D., WILLIAM G. (i) 755,425. 0. 111,317. 45,212. 33,084. 945,038. 0.
CHAIR-LAB MED & PATH (ii) 0. 0. 0. 0. 0. 0. 0.
ARNETT, JENNIFER P. (i) 866,865. 0. 10,661. 13,347. 23,216. 914,089. 0.
CHIEF DEVELOPMENT OFFICER (ii) 0. 0. 0. 0. 0. 0. 0.
HARA M.D., AMY K. (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE (ii) 702,507. 0. 114,655. 37,140. 37,237. 891,539. 0.
CAMILLERI M.D., MICHAEL (i) 635,519. 0. 206,443. 12,200. 28,916. 883,078. 0.
FORMER KEY EMPLOYEE (ii) 0. 0. 0. 0. 0. 0. 0.
WALD M.D., JOHN T. (i) 669,390. 0. 108,419. 53,419. 34,803. 866,031. 0.
KENDRICK M.D., MICHAEL L. (i) 667,130. 0. 120,581. 40,404. 32,821. 860,936. 0.
CHAIR-SURGERY (ii) 0. 0. 0. 0. 0. 0. 0.
KHAN, RITA G. (i) 0. 0. 0. 0. 0. 0. 0.
FORMER KEY EMPLOYEE (ii) 732,379. 0. 25,646. 39,970. 18,806. 816,801. 0.
FONSECA M.D., RAFAEL (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE (ii) 540,243. 0. 194,526. 43,071. 35,702. 813,542. 0.
LEIBOVICH M.D., BRADLEY C. (i) 621,534. 0. 112,965. 43,146. 32,728. 810,373. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
232112 10-18-22 92
DOWDY M.D., SEAN C. (i) 654,963. 0. 77,632. 34,805. 35,537. 802,937. 0.
CHIEF VALUE OFFICER (ii) 0. 0. 0. 0. 0. 0. 0.
LOFTUS M.D., CONOR G. (i) 647,129. 0. 73,589. 33,067. 32,728. 786,513. 0.
DIDEHBAN, ROSHANAK (i) 426,643. 0. 63,198. 24,409. 8,424. 522,674. 0.
TRUSTEE (ii) 208,701. 0. 37,594. 0. 3,525. 249,820. 0.
GALANIS M.D., EVANTHIA (i) 602,061. 0. 94,609. 38,258. 32,605. 767,533. 0.
EXECUTIVE DEAN OF DEVELOPMENT (ii) 0. 0. 0. 0. 0. 0. 0.
GERTZ M.D., MORIE A. (i) 529,421. 0. 196,812. 12,200. 25,884. 764,317. 0.
MCLAUGHLIN M.D., SARAH A. (i) 0. 0. 0. 0. 0. 0. 0.
TRUSTEE (ii) 619,782. 0. 63,143. 28,219. 7,125. 718,269. 0.
BROWN M.D., MICHAEL J. (i) 563,885. 0. 80,296. 37,828. 35,199. 717,208. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
CIMA M.D., ROBERT R. (i) 557,874. 0. 82,484. 42,648. 31,454. 714,460. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
OKUNO M.D., SCOTT H. (i) 561,421. 0. 70,913. 48,793. 26,654. 707,781. 0.
LUETMER M.D., PATRICK H. (i) 540,785. 0. 120,475. 12,213. 32,951. 706,424. 0.
FRANK M.D., IGOR (i) 570,034. 0. 61,734. 33,283. 34,022. 699,073. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
KHAN M.D., AMIR R. (i) 534,074. 0. 69,229. 41,519. 32,396. 677,218. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
PETERS M.D., STEVE G. (i) 535,766. 0. 78,252. 12,200. 28,112. 654,330. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
GAZELKA M.D., HALENA M. (i) 498,687. 0. 85,397. 6,100. 16,420. 606,604. 0.
FORMER KEY EMPLOYEE (ii) 21,140. 0. 44. 32,985. 591. 54,760. 0.
FAMUYIDE M.B.B.S., ABIMBOLA O. (i) 474,595. 0. 91,223. 49,995. 24,829. 640,642. 0.
TRUSTEE (ii) 0. 0. 0. 0. 0. 0. 0.
FRANCIS, JAMES R. (i) 0. 0. 0. 0. 0. 0. 0.
ASST TREASURER (ii) 488,877. 0. 58,851. 61,591. 28,314. 637,633. 0.
232112 10-18-22 93
HORLOCKER M.D., TERESE T. (i) 525,625. 0. 67,544. 12,204. 26,465. 631,838. 0.
PHYSICIAN (ii) 0. 0. 0. 0. 0. 0. 0.
DUNN, AJANI N. (i) 0. 0. 0. 0. 0. 0. 0.
ASST SECY (ii) 527,713. 0. 8,243. 26,454. 37,736. 600,146. 0.
HAYES M.D., SHARONNE N. (i) 413,634. 0. 97,038. 39,565. 25,291. 575,528. 0.
LUCCHINETTI M.D., CLAUDIA F. (i) 436,001. 0. 54,857. 48,467. 29,515. 568,840. 0.
TRUSTEE (ii) 0. 0. 0. 0. 0. 0. 0.
DIETER, HEIDI L. (i) 458,071. 0. 32,287. 38,059. 12,017. 540,434. 0.
CHAIR-RESEARCH ADMIN (ii) 0. 0. 0. 0. 0. 0. 0.
POE, JOHN D. (i) 53,063. 0. 210. 1,604. 4,870. 59,747. 0.
CHAIR-EDUCATION ADMIN (ii) 406,614. 0. 1,945. 36,197. 19,054. 463,810. 0.
DIASIO M.D., ROBERT B. (i) 372,459. 0. 81,182. 6,188. 27,830. 487,659. 0.
HUBERT, SHERRY L. (i) 0. 0. 0. 0. 0. 0. 0.
ASST SECY (ii) 366,166. 0. 20,244. 48,423. 34,580. 469,413. 0.
NARR M.D., BRADLY J. (i) 309,378. 0. 101,953. 12,200. 27,716. 451,247. 0.
NORBY, SUSAN M. (i) 0. 0. 0. 0. 0. 0. 0.
FORMER OFFICER (ii) 347,885. 0. 16,364. 42,628. 29,563. 436,440. 0.
BOLTON, JEFFREY W. (i) 0. 0. 0. 0. 0. 0. 0.
FORMER OFFICER (ii) 0. 0. 406,549. 0. 0. 406,549. 35,921.
CAINE, NATALIE A. (i) 341,246. 0. 2,306. 21,086. 36,558. 401,196. 0.
CAO-ROCHESTER (ii) 0. 0. 0. 0. 0. 0. 0.
GREENE M.D., EDDIE L. (i) 286,967. 0. 28,415. 42,105. 24,802. 382,289. 0.
TRUSTEE (ii) 0. 0. 0. 0. 0. 0. 0.
BROWN, WILLIAM A. (i) 0. 0. 0. 0. 0. 0. 0.
ASST TREASURER (ii) 266,298. 0. 4,556. 10,086. 27,511. 308,451. 0.
HAEFLINGER, RICKY J. (i) 0. 0. 175,431. 0. 0. 175,431. 0.
FORMER OFFICER (ii) 0. 0. 0. 0. 0. 0. 0.
(i)
(ii)
232112 10-18-22 94
Part III Supplemental Information
Provide the information, explanation, or descriptions required for Part I, lines 1a, 1b, 3, 4a, 4b, 4c, 5a, 5b, 6a, 6b, 7, and 8, and for Part II. Also complete this part for any additional information.
PART I, LINE 1A:
EXTERNAL TRUSTEES MAY BE REIMBURSED FOR ACTUAL TRAVEL EXPENSES, INCLUDING
FIRST CLASS TRAVEL, RELATED TO MAYO BUSINESS. THIS REIMBURSEMENT MAY
INCLUDE PRIVATE AIR TRAVEL, IN WHICH CASE REIMBURSEMENT IS LIMITED TO THE
COST OF A FIRST CLASS TICKET AND THE AMOUNT IS GROSSED UP AND TREATED AS
TAXABLE INCOME.
IN 2022, MATTHEW R. CALLSTROM M.D., IGOR FRANK M.D. AND EVANTHIA GALANIS
M.D. WERE PROVIDED BUSINESS/FIRST-CLASS TRAVEL. THE TRAVEL WAS NOT TREATED
AS TAXABLE COMPENSATION AS ALL FLIGHTS WERE BUSINESS RELATED.
TRAVEL FOR COMPANIONS IS AVAILABLE TO ALL TRUSTEES AND EX-OFFICIOS SO THAT
SPOUSES CAN ACCOMPANY THEM TO THE SITE OF BOARD MEETINGS AND FOR OTHER
BUSINESS RELATED PURPOSES. IN 2022, JAY ALIX, JENNIFER P. ARNETT, KATHERINE
BAICKER, CLAUDIA F. LUCCHINETTI M.D., MICHAEL K. POWELL, CHARANJIT S. RIHAL
M.D., ROBIN R. ROBERTS AND RANDOLPH C. STEER M.D. RECEIVED SPOUSAL TRAVEL,
WHICH WAS GROSSED UP AND TREATED AS TAXABLE INCOME.
MOVING EXPENSE REIMBURSEMENT IS PROVIDED TO QUALIFYING EMPLOYEES WHEN

232113 10-18-22 95
JUSTIFIED BY BUSINESS NEED. REIMBURSEMENT MAY INCLUDE TRAVEL FOR
COMPANIONS. IN 2022, ONE OR MORE LISTED PERSONS RECEIVED SUCH A PAYMENT
WHICH INCLUDED A GROSS UP PAYMENT. THE GROSS UP PAYMENT WAS TREATED AS
ADDITIONAL TAXABLE COMPENSATION.
PURSUANT TO INSTITUTIONAL POLICIES, CERTAIN AWARDS HAVE A TAX GROSS-UP
APPLIED IN ORDER TO NOT DIMINISH THE RECOGNITION AND CELEBRATORY NATURE OF
THE AWARD. ONE OR MORE LISTED PERSONS RECEIVED AN AWARD, WHICH WAS TREATED
AS TAXABLE COMPENSATION TO THE INDIVIDUALS.
THE PERSONAL SERVICES THAT WERE PROVIDED ARE INCOME TAX PREPARATION
SERVICES THAT, IN ACCORDANCE WITH MAYO POLICY, ARE AVAILABLE TO MAYO CLINIC
VOTING/CONSULTING STAFF. ONE OR MORE LISTED PERSONS RECEIVED THIS SERVICE,
WHICH WAS TREATED AS TAXABLE COMPENSATION TO THE INDIVIDUALS.
PART I, LINES 4B-C:
THIS ENTITY OR ITS AFFILIATE HAS A SUPPLEMENTAL RETIREMENT PLAN (SRP)
DESIGNED TO ROUGHLY APPROXIMATE AN EXTENSION OF THE BENEFITS UNDER THE MAYO
PENSION PLAN TO INCOME ABOVE THE INTERNAL REVENUE CODE QUALIFIED PLAN LIMIT
232113 10-18-22 96
IN SECTION 401(A)(17). STARTING JANUARY 1, 2011, ALL SRP BENEFITS ARE PAID
AS AN ANNUAL TAXABLE CASH PAYMENT.
THE FOLLOWING INDIVIDUALS PARTICIPATED IN OR RECEIVED A PAYMENT FROM THE
SUPPLEMENTAL RETIREMENT PLAN. AMOUNTS ARE INCLUDED IN SCHEDULE J, PART II,
COLUMN (B)(III).
AMMASH M.D., NASER M. $113,509
ARNETT, JENNIFER P. $ 4,480
BOLTON, JEFFREY W. $370,628
BROWN M.D., MICHAEL J. $ 67,134
CAINE, NATALIE A. $ 716
CALLSTROM M.D., MATTHEW R. $133,609
CAMILLERI M.D., MICHAEL $116,010
CIMA M.D., ROBERT R. $ 74,633
CLARKE M.D., MICHELLE J. $123,357
DAHLEN, DENNIS E. $143,487
DIASIO M.D., ROBERT B. $ 64,492
DIDEHBAN, ROSHANAK $ 60,501

232113 10-18-22 97
DIETER, HEIDI L. $ 30,126
DOWDY M.D., SEAN C. $ 67,916
DUNN, AJANI N. $ 3,791
FAMUYIDE M.B.B.S., ABIMBOLA O. $ 58,957
FARRUGIA M.D., GIANRICO $722,101
FONSECA M.D., RAFAEL $111,757
FRANCIS, JAMES R. $ 53,065
FRANK M.D., IGOR $ 57,262
GALANIS M.D., EVANTHIA $ 89,159
GAZELKA M.D., HALENA M. $ 32,664
GERTZ M.D., MORIE A. $ 84,457
GORES M.D., GREGORY J. $209,763
GORMAN, PAUL A. $140,092
GRAY M.D., RICHARD J. $324,738
GREENE M.D., EDDIE L. $ 24,809
HARA M.D., AMY K. $113,169
HARPER JR., M.D., CHARLES M. $223,863
HAYES M.D., SHARONNE N. $ 65,851
HORLOCKER M.D., TERESE T. $ 63,074

232113 10-18-22 98
HUBERT, SHERRY L. $ 17,058
KENDRICK M.D., MICHAEL L. $108,561
KHAN M.D., AMIR R. $ 65,301
KHAN, RITA G. $ 21,269
KRAUSS M.D., WILLIAM E. $247,834
LANZINO M.D., GIUSEPPE $246,714
LEIBOVICH M.D., BRADLEY C. $ 92,619
LOFTUS M.D., CONOR G. $ 72,098
LUCCHINETTI M.D., CLAUDIA F. $ 47,477
LUETMER M.D., PATRICK H. $106,029
MARSH M.D., W. RICHARD $225,710
MCLAUGHLIN M.D., SARAH A. $ 62,008
MENKOSKY, PAULA E. $145,275
MORICE M.D., WILLIAM G. $108,034
MURPHY, JOSHUA B. $229,142
NARR M.D., BRADLY J. $ 61,213
NORBY, SUSAN M. $ 13,627
OKUNO M.D., SCOTT H. $ 65,697
OTLEY M.D., CLARK C. $167,962

232113 10-18-22 99
PAGNANO M.D., MARK W. $135,347
PETERS M.D., STEVE G. $ 65,804
PICHELMANN M.D., MARK A. $186,004
POE, JOHN D. $0
RIHAL M.D., CHARANJIT S. $124,292
SHAH M.D., VIJAY $135,686
THIELEN M.D., KENT R. $324,738
WALD M.D., JOHN T. $103,229
WILLIAMS M.D., AMY W. $178,140
WILLIAMSON, MARY J. $167,752
ZORN, CHRISTINA K. $116,164
UNDER MAYO CLINIC'S ROYALTY SHARING POLICY, INVENTORS, INCLUDING LISTED
PERSONS, ARE ENTITLED TO SHARE IN A PORTION OF ROYALTIES RECEIVED BY MAYO
INCLUDING INSTANCES WHERE SUCH ROYALTIES ARE IN THE FORM OF EQUITY-BASED
INSTRUMENTS SUCH AS STOCK, WARRANTS, OR PARTNERSHIP INTERESTS.
THE FOLLOWING INDIVIDUALS PARTICIPATED IN AN EQUITY-BASED COMPENSATION
ARRANGEMENT:
232113 10-18-22 100

CAMILLERI M.D., MICHAEL
DOWDY M.D., SEAN C.
FAMUYIDE M.B.B.S., ABIMBOLA O.
HARA M.D., AMY K.
RIHAL M.D., CHARANJIT S.
SHAH M.D., VIJAY
PART II:
COMPENSATION PAID TO BOARD MEMBERS IS PRIMARILY FOR PROFESSIONAL
RESPONSIBILITIES AS PHYSICIANS, ADMINISTRATORS, OR EMPLOYEES OF THE
ORGANIZATION.
232113 10-18-22 101

ENTITY 1
SCHEDULE K Supplemental Information on Tax-Exempt Bonds OMB No. 1545-0047
(Form 990) Complete if the organization answered "Yes" on Form 990, Part IV, line 24a. Provide descriptions, 2022
Department of the Treasury explanations, and any additional information in Part VI. Open to Public
Internal Revenue Service Attach to Form 990. Go to www.irs.gov/Form990 for instructions and the latest information. Inspection
Part I Bond Issues SEE PART VI FOR COLUMN (F) CONTINUATIONS
(a) Issuer name (b) Issuer EIN (c) CUSIP # (d) Date issued (e) Issue price (f) Description of purpose (g) Defeased (h) On behalf (i) Pooled
of issuer financing
Yes No Yes No Yes No
CONSTRUCTION OF HEALTH
A CITY OF ROCHESTER, MINNESOTA 41-6005494 771902FE8 04/10/08 330,000,000.CARE FACILITIES & REFUND X X X
REFUND 1992 AND 2001
B CITY OF ROCHESTER, MINNESOTA 41-6005494 771902GA5 05/05/11 293,208,150.BONDS X X X
C CITY OF ROCHESTER, MINNESOTA 41-6005494 771902GW7 05/08/14 120,000,000.CARE FACILITIES X X X
D CITY OF ROCHESTER, MINNESOTA 41-6005494 771902GB3 12/31/15 494,267.CARE FACILITIES X X X
Part II Proceeds
A B C D
1 Amount of bonds retired •••••••••••••••••••••••••••••• 130,000,000. 135,494,267.
2 Amount of bonds legally defeased •••••••••••••••••••••••••
3 Total proceeds of issue ••••••••••••••••••••••••••••••• 325,948,187. 293,208,150. 120,012,445. 494,267.
4 Gross proceeds in reserve funds ••••••••••••••••••••••••••
5 Capitalized interest from proceeds ••••••••••••••••••••••••• 8,864,264. 310,855.
6 Proceeds in refunding escrows ••••••••••••••••••••••••••
7 Issuance costs from proceeds ••••••••••••••••••••••••••• 2,230,808. 2,088,829. 400,343.
8 Credit enhancement from proceeds ••••••••••••••••••••••••
9 Working capital expenditures from proceeds ••••••••••••••••••••
10 Capital expenditures from proceeds •••••••••••••••••••••••• 87,603,115. 119,301,247.
11 Other spent proceeds ••••••••••••••••••••••••••••••• 227,250,000. 291,119,321. 494,267.
12 Other unspent proceeds ••••••••••••••••••••••••••••••
13 Year of substantial completion ••••••••••••••••••••••••••• 2010 2011 2016 2016
Yes No Yes No Yes No Yes No
14 Were the bonds issued as part of a refunding issue of tax-exempt bonds (or,
if issued prior to 2018, a current refunding issue)? •••••••••••••••••• X X X X
15 Were the bonds issued as part of a refunding issue of taxable bonds (or, if
issued prior to 2018, an advance refunding issue)? ••••••••••••••••• X X X X
16 Has the final allocation of proceeds been made? •••••••••••••••••• X X X X
17 Does the organization maintain adequate books and records to support the
final allocation of proceeds? •••••••••••••••••••••••••••• X X X X
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990. Schedule K (Form 990) 2022
232121 10-28-22 102

ENTITY 2
of issuer financing
A CITY OF ROCHESTER, MINNESOTA 41-6005494 771902GY3 05/03/16 75,000,000.REFUND 2006 BONDS X X X
B CITY OF ROCHESTER, MINNESOTA 41-6005494 771902HE6 10/13/16 293,825,280.REFUND 2000 BONDS X X X

C CITY OF ROCHESTER, MINNESOTA 41-6005494 771902HF3 10/16/18 200,152,000.CARE FACILITIES X X X
D CITY OF ROCHESTER, MINNESOTA 41-6005494 000000000 05/15/20 130,000,000.REFUND 2008 BONDS X X X

Part II Proceeds
A B C D
1 Amount of bonds retired ••••••••••••••••••••••••••••••
3 Total proceeds of issue ••••••••••••••••••••••••••••••• 75,000,000. 293,828,470. 201,883,614. 130,000,000.
5 Capitalized interest from proceeds ••••••••••••••••••••••••• 2,361,460. 9,157,904.
7 Issuance costs from proceeds ••••••••••••••••••••••••••• 1,467,010. 1,140,947.
10 Capital expenditures from proceeds •••••••••••••••••••••••• 191,584,762.
11 Other spent proceeds ••••••••••••••••••••••••••••••• 75,000,000. 290,000,000. 130,000,000.
12 Other unspent proceeds ••••••••••••••••••••••••••••••
13 Year of substantial completion ••••••••••••••••••••••••••• 2016 2016 2020 2020
if issued prior to 2018, a current refunding issue)? •••••••••••••••••• X X X X
issued prior to 2018, an advance refunding issue)? ••••••••••••••••• X X X X
16 Has the final allocation of proceeds been made? •••••••••••••••••• X X X X
final allocation of proceeds? •••••••••••••••••••••••••••• X X X X
232121 10-28-22 103

ENTITY 3
of issuer financing
REFUND 2012 AND 2015
A CITY OF ROCHESTER, MINNESOTA 41-6005494 771902HM8 04/12/22 305,570,347.BONDS AND CONSTRUCTION X X X
D
Part II Proceeds
A B C D
1 Amount of bonds retired ••••••••••••••••••••••••••••••
3 Total proceeds of issue ••••••••••••••••••••••••••••••• 306,357,339.
5 Capitalized interest from proceeds ••••••••••••••••••••••••• 6,735,393.
7 Issuance costs from proceeds ••••••••••••••••••••••••••• 1,518,194.
10 Capital expenditures from proceeds •••••••••••••••••••••••• 49,693,357.
11 Other spent proceeds ••••••••••••••••••••••••••••••• 204,031,250.
12 Other unspent proceeds •••••••••••••••••••••••••••••• 44,379,146.
13 Year of substantial completion •••••••••••••••••••••••••••
if issued prior to 2018, a current refunding issue)? •••••••••••••••••• X
issued prior to 2018, an advance refunding issue)? ••••••••••••••••• X
16 Has the final allocation of proceeds been made? •••••••••••••••••• X
final allocation of proceeds? •••••••••••••••••••••••••••• X
232121 10-28-22 104

ENTITY 1
Schedule K (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part III Private Business Use
A B C D
1 Was the organization a partner in a partnership, or a member of an LLC, Yes No Yes No Yes No Yes No
which owned property financed by tax-exempt bonds? •••••••••••••••• X X
2 Are there any lease arrangements that may result in private business use of
bond-financed property? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X X
3a Are there any management or service contracts that may result in private
business use of bond-financed property? ••••••••••••••••••••••• X X
b If "Yes" to line 3a, does the organization routinely engage bond counsel or other outside
counsel to review any management or service contracts relating to the financed property?
c Are there any research agreements that may result in private business use of
bond-financed property? ••••••••••••••••••••••••••••••• X X
d If "Yes" to line 3c, does the organization routinely engage bond counsel or other
outside counsel to review any research agreements relating to the financed property? •
4 Enter the percentage of financed property used in a private business use by entities
other than a section 501(c)(3) organization or a state or local government ••••••• % % 1.02 % .00 %
5 Enter the percentage of financed property used in a private business use as a
result of unrelated trade or business activity carried on by your organization,
another section 501(c)(3) organization, or a state or local government ••••••••• % % .02 % .00 %
6 Total of lines 4 and 5 ••••••••••••••••••••••••••••••••• % % 1.04 % .00 %
7 Does the bond issue meet the private security or payment test? •••••••••••• X X
8a Has there been a sale or disposition of any of the bond-financed property to a non-
governmental person other than a 501(c)(3) organization since the bonds were issued? X X
b If "Yes" to line 8a, enter the percentage of bond-financed property sold or
disposed of ••••••••••••••••••••••••••••••••••••• % % % %
c If "Yes" to line 8a, was any remedial action taken pursuant to Regulations
sections 1.141-12 and 1.145-2? ••••••••••••••••••••••••••••
9 Has the organization established written procedures to ensure that all
nonqualified bonds of the issue are remediated in accordance with the
requirements under Regulations sections 1.141-12 and 1.145-2?•••••••••••• X X
Part IV Arbitrage
A B C D
1 Has the issuer filed Form 8038-T, Arbitrage Rebate, Yield Reduction and Yes No Yes No Yes No Yes No
Penalty in Lieu of Arbitrage Rebate? ••••••••••••••••••••••••• X X X X
2 If "No" to line 1, did the following apply?
a Rebate not due yet? ••••••••••••••••••••••••••••••••• X X X X
b Exception to rebate? ••••••••••••••••••••••••••••••••• X X X X
c No rebate due? •••••••••••••••••••••••••••••••••••• X X X X
If "Yes" to line 2c, provide in Part VI the date the rebate computation was
performed ••••••••••••••••••••••••••••••••••••••
3 Is the bond issue a variable rate issue? •••••••••••••••••••••••• X X X X
232122 10-28-22 Schedule K (Form 990) 2022
ENTITY 2
A B C D
which owned property financed by tax-exempt bonds? •••••••••••••••• X X X
bond-financed property? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X X X
business use of bond-financed property? ••••••••••••••••••••••• X X X
bond-financed property? ••••••••••••••••••••••••••••••• X X X
outside counsel to review any research agreements relating to the financed property? • X X
other than a section 501(c)(3) organization or a state or local government ••••••• .11 % % .00 % .01 %
another section 501(c)(3) organization, or a state or local government ••••••••• .25 % % .00 % .02 %
6 Total of lines 4 and 5 ••••••••••••••••••••••••••••••••• .36 % % .00 % .03 %
7 Does the bond issue meet the private security or payment test? •••••••••••• X X X
governmental person other than a 501(c)(3) organization since the bonds were issued? X X X
disposed of ••••••••••••••••••••••••••••••••••••• % % % %
sections 1.141-12 and 1.145-2? ••••••••••••••••••••••••••••
requirements under Regulations sections 1.141-12 and 1.145-2?•••••••••••• X X X
Part IV Arbitrage
A B C D
Penalty in Lieu of Arbitrage Rebate? ••••••••••••••••••••••••• X X X X
a Rebate not due yet? ••••••••••••••••••••••••••••••••• X X X X
b Exception to rebate? ••••••••••••••••••••••••••••••••• X X X X
c No rebate due? •••••••••••••••••••••••••••••••••••• X X X X
performed ••••••••••••••••••••••••••••••••••••••
3 Is the bond issue a variable rate issue? •••••••••••••••••••••••• X X X X
232122 10-28-22 Schedule K (Form 990) 2022
ENTITY 3
A B C D
which owned property financed by tax-exempt bonds? •••••••••••••••• X
bond-financed property? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ X
business use of bond-financed property? ••••••••••••••••••••••• X
bond-financed property? ••••••••••••••••••••••••••••••• X
outside counsel to review any research agreements relating to the financed property? • X
other than a section 501(c)(3) organization or a state or local government ••••••• .04 % % % %
another section 501(c)(3) organization, or a state or local government ••••••••• .02 % % % %
6 Total of lines 4 and 5 ••••••••••••••••••••••••••••••••• .06 % % % %
7 Does the bond issue meet the private security or payment test? •••••••••••• X
governmental person other than a 501(c)(3) organization since the bonds were issued? X
disposed of ••••••••••••••••••••••••••••••••••••• % % % %
sections 1.141-12 and 1.145-2? ••••••••••••••••••••••••••••
requirements under Regulations sections 1.141-12 and 1.145-2?•••••••••••• X
Part IV Arbitrage
A B C D
Penalty in Lieu of Arbitrage Rebate? ••••••••••••••••••••••••• X
a Rebate not due yet? ••••••••••••••••••••••••••••••••• X
b Exception to rebate? ••••••••••••••••••••••••••••••••• X
c No rebate due? •••••••••••••••••••••••••••••••••••• X
performed ••••••••••••••••••••••••••••••••••••••
3 Is the bond issue a variable rate issue? •••••••••••••••••••••••• X
232122 10-28-22 Schedule K (Form 990) 2022
ENTITY 1
Part IV Arbitrage (continued)
A B C D
4a Has the organization or the governmental issuer entered into a qualified Yes No Yes No Yes No Yes No
hedge with respect to the bond issue? •••••••••••••••••••••••• X X X X
b Name of provider •••••••••••••••••••••••••••••••••••
c Term of hedge ••••••••••••••••••••••••••••••••••••
d Was the hedge superintegrated? •••••••••••••••••••••••••••
e Was the hedge terminated? •••••••••••••••••••••••••••••
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? •••••• X X X X
c Term of GIC •••••••••••••••••••••••••••••••••••••
d Was the regulatory safe harbor for establishing the fair market value of the GIC satisfied?
6 Were any gross proceeds invested beyond an available temporary period? •••••• X X X X
7 Has the organization established written procedures to monitor the
requirements of section 148? ••••••••••••••••••••••••••••• X X X X
Part V Procedures To Undertake Corrective Action
A B C D
Has the organization established written procedures to ensure that violations Yes No Yes No Yes No Yes No
of federal tax requirements are timely identified and corrected through the
voluntary closing agreement program if self-remediation isn't available under
applicable regulations? •••••••••••••••••••••••••••••••• X X X X
Part VI Supplemental Information. Provide additional information for responses to questions on Schedule K. See instructions.
232123 10-28-22 Schedule K (Form 990) 2022

SEE PART VI SUPPLEMENTAL INFORMATION SHEET
ENTITY 2
A B C D
hedge with respect to the bond issue? •••••••••••••••••••••••• X X X X
c Term of hedge ••••••••••••••••••••••••••••••••••••
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? •••••• X X X X
c Term of GIC •••••••••••••••••••••••••••••••••••••
6 Were any gross proceeds invested beyond an available temporary period? •••••• X X X X
requirements of section 148? ••••••••••••••••••••••••••••• X X X X
A B C D
applicable regulations? •••••••••••••••••••••••••••••••• X X X X
232123 10-28-22 Schedule K (Form 990) 2022

ENTITY 3
A B C D
hedge with respect to the bond issue? •••••••••••••••••••••••• X
c Term of hedge ••••••••••••••••••••••••••••••••••••
5a Were gross proceeds invested in a guaranteed investment contract (GIC)? •••••• X
c Term of GIC •••••••••••••••••••••••••••••••••••••
6 Were any gross proceeds invested beyond an available temporary period? •••••• X
requirements of section 148? ••••••••••••••••••••••••••••• X
A B C D
applicable regulations? •••••••••••••••••••••••••••••••• X
SCHEDULE K, PART I, BOND ISSUES:
(A) ISSUER NAME: CITY OF ROCHESTER, MINNESOTA
(F) DESCRIPTION OF PURPOSE:
CONSTRUCTION OF HEALTH CARE FACILITIES & REFUND 1998 BONDS
SCHEDULE K, PART IV, ARBITRAGE, LINE 2C:

DATE THE REBATE COMPUTATION WAS PERFORMED: 03/05/2013



SCHEDULE K, PART I, COLUMN (E) AND PART II, LINE 3

THE DIFFERENCE BETWEEN PART I, COLUMN (E) AND PART II, LINE 3 FOR THE
232123 10-28-22 Schedule K (Form 990) 2022
Part VI Supplemental Information. Provide additional information for responses to questions on Schedule K. See instructions. (continued)
BOND ISSUES ARE INVESTMENT EARNINGS OR LOSSES.
SCHEDULE K, PART IV, ARBITRAGE CALCULATIONS FOR 2015 BOND ISSUES

DURING 2015 PROPERTY THAT WAS FINANCED BY PREVIOUSLY ISSUED BONDS WAS
SOLD. REMEDIAL ACTION WAS REQUIRED DUE TO THE SALE OF BOND-FINANCED
PROPERTY WHICH RESULTED IN AN ALLOCABLE PORTION OF EACH OF THE
PREVIOUSLY ISSUED BONDS TO BE TREATED AS HAVING BEEN REISSUED -
RESULTING IN THE 2015 BOND ISSUES REFLECTED ON THIS SCHEDULE K. THE
TRANSFERRED/SALE PROCEEDS WERE DEEMED TO HAVE BEEN SPENT IMMEDIATELY TO
RETIRE THE ALLOCABLE PORTIONS OF THE PREVIOUS BOND ISSUES. THE 2015
TRANSFERRED/SALE PROCEEDS WERE REDIRECTED TO ANOTHER QUALIFYING PROJECT
ALREADY COMPLETED RESULTING IN ZERO INVESTMENT EARNINGS FOR PURPOSES OF
THE ARBITRAGE CALCULATIONS. SINCE THERE WERE NO INVESTMENT EARNINGS
RELATED TO THE PROCEEDS, WE HAVE INDICATED FOR PART IV (ARBITRAGE),
LINE 2C THAT NO REBATE WAS DUE AS OF DECEMBER 31, 2020.
232124 10-28-22 Schedule K (Form 990) 2022

SCHEDULE L Transactions With Interested Persons OMB No. 1545-0047
(Form 990) Complete if the organization answered "Yes" on Form 990, Part IV, line 25a, 25b, 26, 27, 28a,
28b, or 28c, or Form 990-EZ, Part V, line 38a or 40b. 2022
Department of the Treasury Attach to Form 990 or Form 990-EZ. Open To Public
Part I Excess Benefit Transactions (section 501(c)(3), section 501(c)(4), and section 501(c)(29) organizations only).
Complete if the organization answered "Yes" on Form 990, Part IV, line 25a or 25b, or Form 990-EZ, Part V, line 40b.
1 (b) Relationship between disqualified (d) Corrected?
(a) Name of disqualified person person and organization (c) Description of transaction
Yes No
2 Enter the amount of tax incurred by the organization managers or disqualified persons during the year under
section 4958 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ $
3 Enter the amount of tax, if any, on line 2, above, reimbursed by the organization ~~~~~~~~~~~~~~~~~~ $
Part II Loans to and/or From Interested Persons.

Complete if the organization answered "Yes" on Form 990-EZ, Part V, line 38a or Form 990, Part IV, line 26; or if the organization
reported an amount on Form 990, Part X, line 5, 6, or 22.
(a) Name of (b) Relationship (c) Purpose (d)fromLoan to or (e) Original (f) Balance due (g) In (h) Approved (i) Written
the by board or
interested person with organization of loan organization? principal amount default? committee? agreement?
To From Yes No Yes No Yes No
Total •••••••••••••••••••••••••••••••••••••••••• $
Part III Grants or Assistance Benefiting Interested Persons.
(a) Name of interested person (b) Relationship between (c) Amount of (d) Type of (e) Purpose of
interested person and assistance assistance assistance
the organization
MERIT SCHOLARSHI 30,000.SCHOLARSHIP
LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ. Schedule L (Form 990) 2022
SEE PART V FOR CONTINUATIONS
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Schedule L (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part IV Business Transactions Involving Interested Persons.
Complete if the organization answered "Yes" on Form 990, Part IV, line 28a, 28b, or 28c.
(a) Name of interested person (b) Relationship between interested (c) Amount of (d) Description of (e) Sharing of
organization's
person and the organization transaction transaction revenues?
Yes No
EMANUEL, ELIZABETH M. FAMILY MEMBER OF FO 88,616.EMPLOYMENT X
FAMUYIDE, OMOLOLA O. FAMILY MEMBER OF TR 109,942.EMPLOYMENT X
GORMAN, ELLEN K. FAMILY MEMBER OF OF 32,860.EMPLOYMENT X
KENDRICK, CONNER D. FAMILY MEMBER OF KE 51,768.EMPLOYMENT X
LAMER M.D., TIM J. FAMILY MEMBER OF KE 617,511.EMPLOYMENT X
LARSON M.D., MARK V. FAMILY MEMBER OF TR 777,138.EMPLOYMENT X
LUETMER M.D., MARIANNE T. FAMILY MEMBER OF FO 276,782.EMPLOYMENT X
MIDTHUN M.D., DAVID E. FAMILY MEMBER OF TR 631,533.EMPLOYMENT X
NEAL M.D., LONZETTA FAMILY MEMBER OF TR 49,786.EMPLOYMENT X
PETERS M.D., MARGOT S. FAMILY MEMBER OF KE 338,694.EMPLOYMENT X
Part V Supplemental Information.
Provide additional information for responses to questions on Schedule L (see instructions).
SCH L, PART III, GRANTS OR ASSISTANCE BENEFITTING INTERESTED PERSONS:
(B) RELATIONSHIP BETWEEN INTERESTED PERSON AND ORGANIZATION:
MERIT SCHOLARSHIP
(C) AMOUNT OF GRANT $ 30,000.
(D) TYPE OF ASSISTANCE: SCHOLARSHIP
SCH L, PART IV, BUSINESS TRANSACTIONS INVOLVING INTERESTED PERSONS:
(A) NAME OF PERSON: EMANUEL, ELIZABETH M.
FAMILY MEMBER OF FORMER OFFICER NORBY, SUSAN M.
(A) NAME OF PERSON: FAMUYIDE, OMOLOLA O.
FAMILY MEMBER OF TRUSTEE FAMUYIDE M.B.B.S., ABIMBOLA O.
(A) NAME OF PERSON: GORMAN, ELLEN K.
FAMILY MEMBER OF OFFICER GORMAN, PAUL A.
Schedule L (Form 990) 2022

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Schedule L (Form 990) MAYO CLINIC 41-6011702 Page 2
Complete this part to provide additional information for responses to questions on Schedule L (see instructions).
(A) NAME OF PERSON: KENDRICK, CONNER D.
FAMILY MEMBER OF KEY EMPLOYEE KENDRICK M.D., MICHAEL L.
(A) NAME OF PERSON: LAMER M.D., TIM J.
FAMILY MEMBER OF KEY EMPLOYEE GAZELKA M.D., HALENA M.
(A) NAME OF PERSON: LARSON M.D., MARK V.
FAMILY MEMBER OF TRUSTEE WILLIAMS M.D., AMY W.
(A) NAME OF PERSON: LUETMER M.D., MARIANNE T.
FAMILY MEMBER OF FORMER KEY EMPLOYEE LUETMER M.D., PATRICK H.
(A) NAME OF PERSON: MIDTHUN M.D., DAVID E.
FAMILY MEMBER OF TRUSTEE WILLIAMS M.D., AMY W.
(A) NAME OF PERSON: NEAL M.D., LONZETTA
FAMILY MEMBER OF TRUSTEE GREENE M.D., EDDIE L.
(A) NAME OF PERSON: PETERS M.D., MARGOT S.
FAMILY MEMBER OF KEY EMPLOYEE PETERS M.D., STEVE G.
232461 04-01-22 Schedule L (Form 990)

114
(A) NAME OF PERSON: POE, KIMBERLY L.
FAMILY MEMBER OF KEY EMPLOYEE POE, JOHN D.
(C) AMOUNT OF TRANSACTION $ 27,938.
(D) DESCRIPTION OF TRANSACTION: EMPLOYMENT
(E) SHARING OF ORGANIZATION REVENUES? = NO
(A) NAME OF PERSON: POE, KRISTIN L.
FAMILY MEMBER OF KEY EMPLOYEE POE, JOHN D.
(A) NAME OF PERSON: SAITO LOFTUS M.D., YURI A.
FAMILY MEMBER OF FORMER KEY EMPLOYEE LOFTUS M.D., CONOR G.
(A) NAME OF PERSON: UHLENKAMP, NOAH B.
FAMILY MEMBER OF FORMER OFFICER NORBY, SUSAN M.
232461 04-01-22 Schedule L (Form 990)

115
(A) NAME OF PERSON: WALD, MICHELLE K.
FAMILY MEMBER OF FORMER KEY EMPLOYEE WALD M.D., JOHN T.
(A) NAME OF PERSON: WILLIAMSON M.D., ERIC E.
FAMILY MEMBER OF KEY EMPLOYEE WILLIAMSON, MARY J.
232461 04-01-22 Schedule L (Form 990)

116
SCHEDULE M Noncash Contributions OMB No. 1545-0047
(Form 990)
Complete if the organizations answered "Yes" on Form 990, Part IV, lines 29 or 30.
2022
Part I Types of Property
(a) (b) (c) (d)
Check if Number of Noncash contribution Method of determining
applicable contributions or amounts reported on noncash contribution amounts
items contributed Form 990, Part VIII, line 1g
1 Art - Works of art ~~~~~~~~~~~~~ X 1 EXPERTS
2 Art - Historical treasures ~~~~~~~~~
3 Art - Fractional interests ~~~~~~~~~~
4 Books and publications ~~~~~~~~~~ X 0.EXPERTS
5 Clothing and household goods ~~~~~~ X 0.EXPERTS
6 Cars and other vehicles ~~~~~~~~~~ X 1 280,000.EXPERTS
7 Boats and planes ~~~~~~~~~~~~~
8 Intellectual property ~~~~~~~~~~~
9 Securities - Publicly traded ~~~~~~~~ X 242 26,240,936.MEAN MARKET VALUE
10 Securities - Closely held stock ~~~~~~~
11 Securities - Partnership, LLC, or
trust interests ~~~~~~~~~~~~~~
12 Securities - Miscellaneous ~~~~~~~~ X 2 5,310,830.EXPERTS
13 Qualified conservation contribution -
Historic structures ~~~~~~~~~~~~
14 Qualified conservation contribution - Other~
15 Real estate - Residential ~~~~~~~~~ X 2 567,700.EXPERTS
16 Real estate - Commercial ~~~~~~~~~ X 4 2,977,529.EXPERTS
17 Real estate - Other ~~~~~~~~~~~~
18 Collectibles ~~~~~~~~~~~~~~~~
19 Food inventory ~~~~~~~~~~~~~~
20 Drugs and medical supplies ~~~~~~~~
21 Taxidermy ~~~~~~~~~~~~~~~~
22 Historical artifacts ~~~~~~~~~~~~
23 Scientific specimens ~~~~~~~~~~~
24 Archeological artifacts ~~~~~~~~~~
25 Other ( JEWELRY ) X 1 8,902.EXPERTS
26 Other ( EQUIPMENT ) X 1 2,800.EXPERTS
27 Other ( TOYS, GAMES, ET ) X 6 0.EXPERTS
28 Other ( FURNITURE ) X 2 0.EXPERTS
29 Number of Forms 8283 received by the organization during the tax year for contributions
for which the organization completed Form 8283, Part V, Donee Acknowledgement ~~~~ 29 5
Yes No
30a During the year, did the organization receive by contribution any property reported in Part I, lines 1 through 28, that it
must hold for at least 3 years from the date of the initial contribution, and which isn't required to be used for
exempt purposes for the entire holding period? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 30a X
b If "Yes," describe the arrangement in Part II.
31 Does the organization have a gift acceptance policy that requires the review of any nonstandard contributions? ~~~~~~ 31 X
32a Does the organization hire or use third parties or related organizations to solicit, process, or sell noncash
contributions? ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 32a X
b If "Yes," describe in Part II.
33 If the organization didn't report an amount in column (c) for a type of property for which column (a) is checked,
describe in Part II.
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Schedule M (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part II Supplemental Information. Provide the information required by Part I, lines 30b, 32b, and 33, and whether the organization
is reporting in Part I, column (b), the number of contributions, the number of items received, or a combination of both. Also complete
this part for any additional information.
SCHEDULE M, PART I, COLUMN (B):
FOR PURPOSES OF SCHEDULE M. MAYO CLINIC IS REPORTING THE NUMBER OF
CONTRIBUTIONS IN COLUMN (B).
SCHEDULE M, LINE 32B:
MAYO CLINIC (MAYO) UTILIZES SEVERAL THIRD PARTIES TO SELL NON-CASH
CONTRIBUTIONS. FOR REAL ESTATE GIFTS, MAYO CONTRACTS WITH REALTORS AND
BROKERS; FOR STOCK AND SECURITY GIFTS MAYO UTILIZES SEVERAL DIFFERENT
BROKERS AND BROKERAGE FIRMS; FOR TANGIBLE PERSONAL PROPERTY, MAYO USES
VARIOUS AUCTION OUTLETS DEPENDING ON THE VALUE (I.E. BONHAMS,
CHRISTIE'S, SOTHEBY'S, ETC.). THESE ARRANGEMENTS ARE ALL FEE AND
COMMISSION-BASED.
SCHEDULE M, LINE 33:
MAYO CLINIC RECEIVED CONTRIBUTIONS OF WORKS OF ART DURING THE YEAR
WHERE NO REVENUE WAS RECORDED. AS PERMITTED UNDER GENERALLY ACCEPTED
ACCOUNTING PRINCIPLES (SFAS 116), MAYO CLINIC DID NOT RECOGNIZE REVENUE
OR CAPITALIZE THE WORKS OF ART.
MAYO CLINIC RECEIVED IN-KIND GIFTS (BOOKS/PUBLICATIONS,
CLOTHING/HOUSEHOLD GOODS, SUPPLIES, ETC.) THROUGHOUT THE YEAR WHERE NO
REVENUE WAS RECORDED AND NO DESCRIPTIVE RECEIPTS WERE ISSUED. REVENUE
IS RECOGNIZED ON GIFTS IN-KIND WHEN THE FAIR MARKET VALUE MEETS
CAPITALIZATION THRESHOLDS OR WHEN TANGIBLE PERSONAL PROPERTY IS SOLD.
232142 09-09-22 Schedule M (Form 990) 2022
118
OMB No. 1545-0047
Supplemental Information to Form 990 or 990-EZ
2022
SCHEDULE O
(Form 990) Complete to provide information for responses to specific questions on
Form 990 or 990-EZ or to provide any additional information.
Internal Revenue Service Go to www.irs.gov/Form990 for the latest information. Inspection
FORM 990 LINE H
MAYO CLINIC IS INCLUDED IN A GROUP EXEMPTION. THE GROUP EXEMPTION
COVERS MAYO CLINIC (THE CENTRAL ORGANIZATION) AND MAYO CLINIC'S
AFFILIATED SUBSIDIARIES (THE SUBORDINATE ORGANIZATIONS). FOR 2022, A
GROUP RETURN (MAYO CLINIC GROUP RETURN - EIN: 38-3952644) WAS FILED
THAT INCLUDED SEVENTEEN OF MAYO CLINIC'S SUBORDINATE ORGANIZATIONS.
IN ACCORDANCE WITH REG. 1.6033-2(D)(5), WITH RESPECT TO THE CENTRAL
ORGANIZATION, MAYO CLINIC HAS REPORTED THE INFORMATION REQUIRED BY REG.
1.6033-2(A)(2)(II)(F), (G) AND (H) ON ITS FORM 990 FOR THE 2022 TAX
YEAR. THIS IS IN LIEU OF CONSOLIDATING SUCH INFORMATION WITH ITS
SUBORDINATE ORGANIZATIONS AND REPORTING SUCH INFORMATION ON THE 2022
MAYO CLINIC GROUP RETURN.
FORM 990, PART III, LINE 4A, PROGRAM SERVICE ACCOMPLISHMENTS:
PATIENT CARE:
MAYO CLINIC IS AN INTEGRATED, NOT-FOR-PROFIT MEDICAL GROUP PRACTICE.
ITS STANDARD OF CARE BRINGS TOGETHER TEAMS OF EXPERTS TO PROVIDE
HIGH-QUALITY, AFFORDABLE AND COMPASSIONATE CARE TO EACH PATIENT
CONSISTENT WITH MAYO CLINIC'S PRIMARY VALUE - THE NEEDS OF THE PATIENT
COME FIRST. MAYO CLINIC'S MISSION IS TO INSPIRE HOPE AND CONTRIBUTE TO
HEALTH AND WELL-BEING BY PROVIDING THE BEST CARE TO EVERY PATIENT
THROUGH INTEGRATED CLINICAL PRACTICE, EDUCATION AND RESEARCH. MAYO
CLINIC'S HERITAGE OF COLLABORATIVE MEDICAL EXPERTISE IS COMBINED WITH
CAREFUL ATTENTION TO INDIVIDUAL PATIENT NEEDS, RESULTING IN A THOROUGH

LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990 or 990-EZ. Schedule O (Form 990) 2022
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Schedule O (Form 990) 2022 Page 2
AND PERSONAL APPROACH TO HEALTH CARE.
PATIENT CARE ADVANCED THROUGH EDUCATION AND RESEARCH IS THE FOUNDATION
OF MAYO CLINIC'S MISSION. TO ACCOMPLISH ITS MISSION, MAYO CLINIC NOT
ONLY PROVIDES A VARIETY OF PROGRAMS IN DIRECT PATIENT CARE, MEDICAL
EDUCATION AND RESEARCH, BUT ALSO SERVES AS THE PARENT ORGANIZATION OF A
MULTI-ENTITY ORGANIZATION CONSISTING OF HOSPITALS, CLINICS, HEALTH CARE
PROVIDERS AND OTHER ENTITIES PROVIDING HEALTH CARE-RELATED SERVICES AND
KNOWLEDGE DELIVERY TO THE PUBLIC THROUGHOUT THE WORLD. IN ROCHESTER,
MAYO CLINIC WORKS COLLABORATIVELY WITH MAYO CLINIC HOSPITAL -
ROCHESTER, AN AFFILIATED ENTITY COMPRISED OF SAINT MARYS CAMPUS AND
METHODIST CAMPUS TO FORM AN INTEGRATED MEDICAL CENTER DEDICATED TO
PROVIDING COMPREHENSIVE DIAGNOSIS AND TREATMENT IN VIRTUALLY EVERY
MEDICAL AND SURGICAL SPECIALTY.
MAYO CLINIC IS ALSO THE SOLE MEMBER OF MAYO CLINIC ARIZONA AND MAYO
CLINIC JACKSONVILLE WHICH PROVIDE SERVICES TO PATIENTS IN THE SOUTHWEST
AND SOUTHEAST REGIONS OF THE UNITED STATES. IN THE MIDWEST, MAYO
CLINIC HEALTH SYSTEM SERVES COMMUNITIES IN MINNESOTA, WISCONSIN, AND
IOWA THROUGH A NETWORK OF COMMUNITY-BASED PHYSICIANS TO PROVIDE QUALITY
HEALTH CARE CLOSE TO HOME, AND ALSO SUPPORTED BY THE HIGHLY SPECIALIZED
EXPERTISE AND RESOURCES OF MAYO CLINIC.
UTILIZING COMMON GOVERNANCE, SHARED SYSTEMS AND STANDARDIZED POLICIES
AND PROCEDURES WHENEVER POSSIBLE, MAYO CLINIC STRIVES TO PROVIDE
CONSISTENT, HIGH QUALITY HEALTH CARE SERVICES AND KNOWLEDGE DELIVERY
WITHIN EVERY ASPECT OF CARE. A 31-MEMBER BOARD OF TRUSTEES COMPRISED
OF A MAJORITY OF PUBLIC MEMBERS ALONG WITH MAYO PHYSICIANS AND

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120
ADMINISTRATORS ENSURE THE ENTIRE ORGANIZATION REMAINS TRUE TO ITS
MISSION AND CULTURE OF PROVIDING FOR THE HEALTH CARE NEEDS OF THE
PUBLIC RATHER THAN FOR PRIVATE BENEFIT.
MAYO CLINIC HAS REINFORCED ITS LEADERSHIP IN PATIENT CARE, RESEARCH AND
EDUCATION TO DRIVE FORWARD THE TRANSFORMATION OF HEALTH CARE OVER THE
NEXT DECADE. WITH DIGITAL INNOVATIONS AND NEW TECHNOLOGIES, MAYO
CLINIC IS MOVING QUICKLY TO EXTEND ITS COMPASSIONATE CARE, EXPERTISE
AND RESEARCH, AND IS REINVESTING IN PEOPLE AND FACILITIES IN THE
COMMUNITIES IT SERVES. MAYO CLINIC HAS ACCELERATED ITS INVESTMENT IN
THE DIGITAL TRANSFORMATION OF HEALTH CARE, AS PART OF ITS 2030 STRATEGY
TO TRANSFORM PATIENT AND CLINICIAN EXPERIENCES AND SOLVE HUMANITY'S
MOST COMPLEX MEDICAL CHALLENGES.
MAYO CLINIC REMAINS TOP-RANKED IN QUALITY MORE THAN ANY OTHER HEALTH
CARE ORGANIZATION BY INDEPENDENT GROUPS, SUCH AS THE NURSING MAGNET
RECOGNITION PROGRAM, PRESS GANEY PATIENT EXPERIENCE AWARDS, THE CENTERS
FOR MEDICARE & MEDICAID SERVICES OVERALL HOSPITAL QUALITY STAR RATINGS,
LEAPFROG HOSPITAL SAFETY SURVEY AND THE AMERICAN COLLEGE OF SURGEONS
NATIONAL SURGICAL QUALITY IMPROVEMENT PROGRAM. FOR THE 2022-2023
PERIOD, MAYO CLINIC WAS AGAIN RANKED AS HAVING THE NO. 1 HOSPITAL IN
THE NATION (MAYO CLINIC HOSPITAL-ROCHESTER) AND TOP-RANKED IN 14
SPECIALTIES BY U.S. NEWS & WORLD REPORT.
MAYO CLINIC OFFERS BOTH SPECIALTY AND PRIMARY CARE IN ITS COMMUNITY
PRACTICES AND MAINTAINS A POPULATION HEALTH OFFICE. IT IS THE CHARGE
OF MAYO'S POPULATION HEALTH COMMITTEE TO TRANSFORM THE WAY COMMUNITY
CARE IS DELIVERED AND IMPROVE PATIENT OUTCOMES WHILE REDUCING THE

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121
OVERALL TOTAL COST OF CARE. POPULATION HEALTH AT MAYO COORDINATES
EXISTING PRACTICE MODELS WITH TRANSFORMATIONAL INITIATIVES TO BETTER
ENGAGE PATIENTS, KEEP THEM HEALTHY, SUPPORT PATIENT WELLNESS GOALS AND
HELP PATIENTS TO BETTER MANAGE CHRONIC ILLNESSES. THE PRACTICE CHANGE
INITIATIVES DEVELOPED, TESTED AND IMPLEMENTED THROUGH THE MAYO MODEL OF
COMMUNITY CARE (MMOCC) ARE AIMED AT IMPROVING THE QUALITY OF LIFE FOR
PATIENTS, REDUCING OVERALL HEALTH CARE COSTS AND BUILDING A SUSTAINABLE
PRACTICE MODEL THAT TRULY SUPPORTS THE NEEDS OF COMMUNITY PATIENTS.
THROUGH MAYO CLINIC'S CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE,
MAYO CLINIC COLLABORATES WITH DIVERSE COMMUNITY MEMBERS TO HELP
COMMUNITY MEDICAL PROVIDERS INCORPORATE PRACTICE-BASED AND
RESEARCH-BASED KNOWLEDGE TO IMPROVE OVERALL COMMUNITY HEALTH OUTCOMES
AND ELIMINATE HEALTH DISPARITIES.
EACH YEAR, PEOPLE FROM ALL 50 STATES AND APPROXIMATELY 130 COUNTRIES
COME TO MAYO CLINIC FOR CARE. DURING 2022, APPROXIMATELY 455,000
PATIENT VISITS WERE RECORDED BY MAYO CLINIC AND ITS AFFILIATED HOSPITAL
IN ROCHESTER, MN. TOTAL PATIENT VISITS FOR MAYO CLINIC AND ITS
AFFILIATES DURING 2022 WERE APPROXIMATELY 1.4 MILLION.
MAYO CLINIC PROVIDES CARE TO PEOPLE COVERED BY GOVERNMENTAL PROGRAMS
SUCH AS MEDICARE AND MEDICAID, AT SUBSTANTIAL DISCOUNTS FROM STANDARD
FEES. CHARITY CARE IS ALSO PROVIDED FOR PATIENTS THAT ARE FINANCIALLY
UNABLE TO PAY FOR SERVICES PROVIDED. IN 2022, THE COST OF
UNCOMPENSATED CARE PROVIDED THROUGH MEDICAID AND MINNESOTA CARE (A
PROGRAM THAT PROVIDES MEDICAL ASSISTANCE FOR LOW INCOME POPULATIONS)
WAS APPROXIMATELY $249,600,000. THIS AMOUNT INCLUDES APPROXIMATELY

232212 10-28-22 Schedule O (Form 990) 2022
122
$39,900,000 PAID TO MINNESOTACARE. THE COST OF UNCOMPENSATED CARE
PROVIDED THROUGH MEDICARE WAS APPROXIMATELY $1,067,100,000 AND THE COST
OF CHARITY CARE PROVIDED IN 2022 WAS APPROXIMATELY $13,400,000.
IN 2022, WITH SYSTEM-WIDE REVENUES OF $16.3 BILLION, MAYO CLINIC AND
ITS AFFILIATES PROVIDED $666 MILLION IN CARE TO PEOPLE IN NEED. THIS
TOTAL INCLUDES $53 MILLION IN CHARITY CARE AND $613 MILLION IN UNPAID
PORTIONS OF MEDICAID AND OTHER INDIGENT CARE PROGRAMS FOR PEOPLE WHO
ARE UNINSURED OR UNDERINSURED. MAYO ALSO PROVIDED $2.9 BILLION IN
UNPAID PORTIONS OF MEDICARE AND OTHER SENIOR PROGRAMS. APPROXIMATELY
56 PERCENT OF MAYO'S TOTAL MEDICAL SERVICES PROVIDED ARE FOR MEDICARE
AND MEDICAID PATIENTS. MAYO CLINIC AND ITS AFFILIATES CONTRIBUTED
APPROXIMATELY $9 MILLION IN CASH AND IN-KIND DONATIONS TO LOCAL
COMMUNITIES.
THE MAYO CLINIC CARE NETWORK CONSISTS OF INDEPENDENT HEALTH-CARE
ORGANIZATIONS THAT SHARE A COMMON GOAL OF IMPROVING DELIVERY OF HEALTH
CARE IN THEIR COMMUNITIES THROUGH HIGH-QUALITY, DATA DRIVEN AND
EVIDENCE BASED MEDICAL CARE. MEMBERS OF THE NETWORK HAVE ACCESS TO
MAYO CLINIC KNOWLEDGE, COLLABORATION TOOLS, DISEASE MANAGEMENT
PROTOCOLS, CLINICAL CARE GUIDELINES, TREATMENT RECOMMENDATIONS, PATIENT
EDUCATION MATERIALS AND CONTINUING MEDICAL EDUCATION OPPORTUNITIES.
THE MAIN GOAL OF THE NETWORK IS TO HELP PEOPLE GAIN THE BENEFITS OF
MAYO CLINIC EXPERTISE WITHOUT HAVING TO TRAVEL TO A MAYO CLINIC
FACILITY. FOR 2022, THE MAYO CLINIC CARE NETWORK CONSISTED OF
APPROXIMATELY 46 MEMBERS LOCATED IN THE UNITED STATES, CHINA, EGYPT,
INDIA, INDONESIA, MEXICO, SAUDI ARABIA, AND THE UNITED ARAB EMIRATES.
THROUGH THE MAYO CLINIC CARE NETWORK, MILLIONS OF PATIENTS AND THEIR
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123
CARE TEAMS HAVE ACCESS TO MAYO CLINIC KNOWLEDGE, CLINICAL PROTOCOLS AND
CONSULTATIONS VIA MAYO'S CONNECTED CARE PLATFORM.
HEALTH INFORMATION IS VIEWED AS AN IMPORTANT PART OF MAYO CLINIC'S
PATIENT CARE MISSION. MAYO CLINIC, IN CONJUNCTION WITH ITS AFFILIATES,
PROVIDES A VARIETY OF HEALTH INFORMATION RESOURCES (BOOKS, NEWSLETTER,
ON-LINE CONTENT, ETC.) TO PATIENTS, CONSUMERS AND THE GENERAL PUBLIC.
MAYO CLINIC'S SOCIAL MEDIA NETWORK IS A NETWORK OF HEALTH CARE
ORGANIZATIONS, HOSPITALS AND MEDICAL PROFESSIONALS COMMITTED TO BROADER
AND DEEPER ENGAGEMENT IN SOCIAL MEDIA TO HELP IMPROVE HEALTH CARE
LITERACY, HEALTH CARE DELIVERY AND POPULATION HEALTH WORLDWIDE.
MAYO CLINIC LIBRARIES REFLECT AN INTEGRATED SYSTEM OF LIBRARIES,
KNOWLEDGE CENTERS AND ARCHIVES. THE BREADTH OF THESE RESOURCES AND
THEIR INTEGRATION MAKES THE MAYO CLINIC LIBRARIES AMONG THE MOST
COMPREHENSIVE IN NORTH AMERICA. THE LIBRARIES SUPPORT HOSPITALIZED
PATIENTS AND THEIR FAMILIES, ALONG WITH SUPPORTING EMPLOYEES,
RESEARCHERS, FACULTY AND STUDENTS IN THEIR CARE OF PATIENTS AND MEDICAL
RESEARCH.
COMMUNITY GIVING AND INVOLVEMENT IS A VALUE-DRIVEN PRIORITY AT MAYO
CLINIC. QUALITY PATIENT CARE IS BEST ADVANCED WITHIN A VIBRANT LOCAL
COMMUNITY, WITH STRONG SOCIETAL FOUNDATIONS, SUCH AS EDUCATION, HEALTH,
INCLUSIVITY, A DIVERSE ECONOMY, SUPPORTIVE SOCIAL SERVICES, AND
AMENITIES THAT MAKE ROCHESTER A DESIRABLE PLACE TO LIVE AND SUPPORT
SOCIAL DETERMINANTS OF HEALTH. MAYO CLINIC'S COMMUNITY CONTRIBUTIONS
PROGRAM PROVIDES FINANCIAL AND IN-KIND SUPPORT TO NON-PROFIT

232212 10-28-22 Schedule O (Form 990) 2022
124
ORGANIZATIONS IN SUPPORT OF THESE EFFORTS.
FORM 990, PART III, LINE 4B, PROGRAM SERVICE ACCOMPLISHMENTS:
MEDICAL RESEARCH:
MAYO CLINIC IS ONE OF THE PREMIER MEDICAL RESEARCH ORGANIZATIONS IN THE
WORLD. INNOVATION AND IMPROVEMENT OF SCIENCE AND THE DELIVERY OF
HEALTH CARE ARE ENHANCED THROUGH MAYO CLINIC'S RESEARCH PROGRAMS.
CLINICAL PRACTICE OBSERVATIONS BECOME THE BASIS FOR RESEARCH STUDIES
AND THE FINDINGS FROM RESEARCH FLOW BACK INTO THE PRACTICE TO IMPROVE
PATIENT CARE AND OUTCOMES. PHYSICIAN/RESEARCHERS AND CAREER
SCIENTISTS' WORK IN TANDEM TO ADVANCE MEDICINE AND TO IMPROVE THE
HEALTH AND WELLBEING OF NOT JUST MAYO CLINIC PATIENTS, BUT ALSO THE
PUBLIC AT LARGE, AS THESE FINDINGS ARE DISSEMINATED WORLDWIDE.
RESEARCH AT MAYO CLINIC INVOLVES MEDICAL PROFESSIONALS COMMITTED TO
SEARCHING FOR ANSWERS TO COMPLEX MEDICAL PROBLEMS WITH THE GOAL OF
BRINGING NEW SOLUTIONS AND ADVANCED CARE RAPIDLY TO PATIENTS THROUGHOUT
THE WORLD. RESEARCH ACTIVITIES INCLUDE BASIC SCIENCE RESEARCH,
CLINICAL TRIALS, TRANSLATIONAL RESEARCH AND HUMAN RESEARCH STUDIES.
DURING 2022, MAYO CLINIC, IN CONJUNCTION WITH ITS AFFILIATES, HAD OVER
5,000 RESEARCH PERSONNEL, 22 CORE LABORATORIES, NEARLY 10,000 ACTIVE
INSTITUTIONAL REVIEW BOARD-APPROVED HUMAN RESEARCH STUDIES,
APPROXIMATELY 1,184 NEW HUMAN RESEARCH STUDIES APPROVED BY THE
INSTITUTIONAL REVIEW BOARD AND OVER 10,600 RESEARCH AND REVIEW ARTICLES
PUBLISHED IN PEER-REVIEWED JOURNALS. MANY OF THESE PERSONNEL,
LABORATORIES, STUDIES AND ARTICLES ARE LOCATED OR PERFORMED BY MAYO
CLINIC IN ROCHESTER, MINNESOTA.

232212 10-28-22 Schedule O (Form 990) 2022
125
FUNDING OF RESEARCH ACTIVITIES AT MAYO CLINIC COMES FROM GRANTS AND
CONTRACTS AS WELL AS FROM MAYO FUNDS AND GIFTS FROM GENEROUS
BENEFACTORS.
FORM 990, PART III, LINE 4C, PROGRAM SERVICE ACCOMPLISHMENTS:
MEDICAL EDUCATION:
MEDICAL EDUCATION, RESEARCH TRAINING, CONTINUOUS MEDICAL LIFE-LONG
LEARNING AND A COMMITTED QUEST FOR NEW KNOWLEDGE ARE INTEGRAL FUNCTIONS
OF MAYO CLINIC. OUR WORLD-RENOWNED EDUCATIONAL PROGRAMS INFORM,
INSTRUCT, AND EMPOWER PHYSICIANS, RESEARCHERS, MEDICAL PROFESSIONALS,
PATIENTS, STUDENTS AND OUR COMMUNITIES TO IMPROVE PUBLIC HEALTH AND
WELL-BEING. THESE PROGRAMS SPAN THE CONTINUUM OF HEALTH CARE AND
ENSURE THE MAYO MODEL OF CARE IS PERPETUATED AND SHARED BROADLY. MAYO
CLINIC IS COMMITTED TO PROVIDING USEFUL, TIMELY KNOWLEDGE AND SKILLS
THAT REFLECT ITS STANDARDS OF EXCELLENCE AND ITS DEDICATION TO FINDING
ANSWERS FOR UNMET PATIENT NEEDS:
EDUCATING THE NEXT GENERATION OF PHYSICIANS, MEDICAL RESEARCHERS AND
HEALTH PROFESSIONALS WITH TRANSFORMATIVE CURRICULA THAT FOCUSES NOT
ONLY ON HELPING THE PATIENT, BUT ALSO IMPROVING THE HEALTH CARE SYSTEM;
SHARING KNOWLEDGE AND INNOVATIVE BEST PRACTICES FREELY IN THE SPIRIT OF
COLLABORATION TO ADVANCE THE SCIENCE OF MEDICINE AND THE ART OF
COMPASSIONATE, PATIENT-CENTERED CARE;
EMPOWERING PEOPLE TO MANAGE THEIR HEALTH THROUGH PATIENT EDUCATION AND
SHARED DECISION-MAKING MEDICAL TRAINING;

232212 10-28-22 Schedule O (Form 990) 2022
126
SPREADING MAYO'S MEDICAL EXPERTISE, EDUCATION AND RESEARCH FINDINGS
THROUGHOUT THE WORLD TO IMPROVE HEALTH CARE FOR ALL.
WORKING COLLABORATIVELY AT A NATIONAL LEVEL TO MODERNIZE AND TRANSFORM
MEDICAL EDUCATION TO ADDRESS AREAS SUCH AS IMPROVING HEALTH CARE
DELIVERY, PHYSICIAN BURN-OUT, POPULATION HEALTH ISSUES, AND TEAM-BASED
CARE.
THE EDUCATIONAL ACTIVITIES OF MAYO CLINIC ARE CENTERED IN MAYO CLINIC
COLLEGE OF MEDICINE AND SCIENCE'S FIVE SCHOOLS:
1. MAYO CLINIC SCHOOL OF GRADUATE MEDICAL EDUCATION IS ONE OF THE
NATION'S OLDEST AND LARGEST SCHOOLS OF GRADUATE MEDICAL EDUCATION WITH
ANNUAL ENROLLMENT OF APPROXIMATELY 1,800 RESIDENT AND FELLOW PHYSICIANS
IN TRAINING. THE SCHOOL TRAINS DOCTORS IN OVER 300 RESIDENCY AND
FELLOWSHIP PROGRAMS, REPRESENTING VIRTUALLY EVERY MEDICAL SPECIALTY.
IN ADDITION, MANY GRADUATES COMPLETE MAYO CLINIC QUALITY ACADEMY
TRAINING - A CONCERTED EFFORT TO EDUCATE AND PREPARE TRAINEES TO
CONTINUOUSLY EXPLORE WAYS TO IMPROVE PATIENT SAFETY, QUALITY CARE AND
ELIMINATE HEALTH DISPARITIES.
2. MAYO CLINIC ALIX SCHOOL OF MEDICINE PROVIDES A FOUR-YEAR MEDICAL
EDUCATION PROGRAM LEADING TO DOCTOR OF MEDICINE DEGREES AND JOINT
MD/PH.D. DEGREES. THE SCHOOL HAS ANNUAL ENROLLMENT OF APPROXIMATELY
460 STUDENTS ON THE ROCHESTER, MINNESOTA; SCOTTSDALE, ARIZONA; AND
JACKSONVILLE, FLORIDA CAMPUSES.
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THE INNOVATIVE AND TRANSFORMATIVE CURRICULUM OF MAYO CLINIC ALIX SCHOOL
OF MEDICINE FOCUSES ON EDUCATING FUTURE PHYSICIAN LEADERS IN
PATIENT-CENTERED, SCIENCE-DRIVEN, TEAM-BASED, HIGH VALUE HEALTH CARE.
STUDENTS ACROSS ALL CAMPUSES ARE SOME OF THE FIRST NATIONWIDE TO TRAIN
AND FIRST NATIONWIDE TO RECEIVE A SCIENCE OF HEALTH CARE DELIVERY
CERTIFICATE IN ADDITION TO A MEDICAL DEGREE. THE INTEGRATED,
TRANSFORMATIVE CURRICULUM IS PART OF AN INITIATIVE TO BETTER PREPARE
STUDENTS FOR THE CHALLENGES OF DELIVERING PATIENT CARE IN A COMPLEX
HEALTH CARE ENVIRONMENT. ADDITIONAL OFFERINGS AT THE SCHOOL INCLUDE
VISITING MEDICAL STUDENT CLERKSHIP PROGRAMS AND SUMMER MINORITY MEDICAL
STUDENT PROGRAMS. THE SCHOOL CULTIVATES STUDENTS TO CONTINUALLY PURSUE
NEW KNOWLEDGE THROUGH DISCOVERY, TRANSLATION AND CLINICAL APPLICATION
TO MEET THE NEEDS OF THEIR PATIENTS.
THE MAYO CLINIC ALIX SCHOOL OF MEDICINE STUDENTS WAS RANKED NO. 14 IN
THE NATION FOR THE BEST MEDICAL SCHOOL FOR RESEARCH FOR THE 2022-2023
PERIOD BY U.S. NEWS & WORLD REPORT.
3. MAYO CLINIC GRADUATE SCHOOL OF BIOMEDICAL SCIENCES HAS A
DISTINGUISHED HISTORY OF PREPARING STUDENTS FOR CAREERS AS COMPETITIVE
BIOMEDICAL RESEARCH INVESTIGATORS. THE SCHOOL OFFERS MASTER'S AND
DOCTORAL DEGREE PROGRAMS FOCUSING SEVERAL BIOMEDICAL SPECIALTIES, AS
WELL AS ONE OF THE FIRST INTERDISCIPLINARY PROGRAMS IN REGENERATIVE
MEDICAL RESEARCH. THE SCHOOL IS A PIONEER IN EXPANDING RESEARCH
TRAINING OPPORTUNITIES FOR STUDENTS FROM BACKGROUNDS UNDERREPRESENTED
IN RESEARCH, INCLUDING VISITING PRE-DOCTORAL AND SUMMER UNDERGRADUATE
RESEARCH PROGRAMS WHERE DIVERSE STUDENTS HAVE THE OPPORTUNITY TO WORK
WITH WORLD-RENOWNED RESEARCHERS AT MAYO CLINIC CAMPUSES IN ARIZONA,

232212 10-28-22 Schedule O (Form 990) 2022
128
FLORIDA AND MINNESOTA. THE MAYO CLINIC GRADUATE SCHOOL OF BIOMEDICAL
SCIENCES HAS AN ANNUAL ENROLLMENT OF APPROXIMATELY 350 STUDENTS.
4. MAYO CLINIC SCHOOL OF HEALTH SCIENCES PREPARES THE ALLIED HEALTH
CARE WORKFORCE OF THE FUTURE IN PROGRAMS RANGING FROM A 10-MONTH
PHLEBOTOMY CERTIFICATE PROGRAM TO A DOCTORATE IN PHYSICAL THERAPY OR
NURSE ANESTHESIA. THE MAYO CLINIC SCHOOL OF HEALTH SCIENCES HAS AN
ANNUAL ENROLLMENT OF APPROXIMATELY 1,600 STUDENTS. WITH CAMPUSES IN
MINNESOTA, FLORIDA AND ARIZONA, THE SCHOOL PREPARES STUDENTS IN OVER
150 PROGRAMS REPRESENTING 50 HEALTH SCIENCE AREAS. THE SCHOOL ALSO
PROVIDES CLINICAL INTERNSHIPS FOR HUNDREDS OF AFFILIATED SCHOOLS.
APPROXIMATELY 480 FACULTY MEMBERS ENSURE EVERY STUDENT RECEIVES
EXTENSIVE PERSONALIZED TRAINING.
5. MAYO CLINIC SCHOOL OF CONTINUOUS PROFESSIONAL DEVELOPMENT PROVIDES A
COMPREHENSIVE SELECTION OF OVER 300 CLINICAL, SURGICAL, ALLIED HEALTH
AND RESEARCH COURSES, AS WELL AS PROGRAMS ON HEALTH CARE ISSUES,
PRACTICE MANAGEMENT AND LEADERSHIP, TO HEALTH CARE PROFESSIONALS
THROUGHOUT THE WORLD. PARTICIPANTS INCLUDE MAYO AND NON-MAYO
ATTENDEES. THE SCHOOL PROVIDES APPROXIMATELY 95,000 LEANER EDUCATIONAL
TOUCHPOINTS ANNUALLY.
MAYO CLINIC COLLEGE OF MEDICINE AND SCIENCE ALSO HAS INITIATED MAYO
CLINIC EDUCATION PLATFORMS TO DEVELOP AND DELIVER ONLINE EDUCATIONAL
OPPORTUNITIES FOR BROAD DISTRIBUTION OF CONTINUING MEDICAL EDUCATION,
FACULTY DEVELOPMENT, STUDENT EDUCATION AND FUTURE PATIENT EDUCATION.
VIDEO SEMINARS AND ONLINE LEARNING MODULES PROVIDE CONSISTENT KNOWLEDGE
DELIVERY ACROSS MULTI-SPECIALTIES AND ALLOW FOR MORE INTERACTIVE

232212 10-28-22 Schedule O (Form 990) 2022
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FACULTY/STUDENT PARTICIPATION IN THE CLASSROOM SETTING. ONLINE
LEARNING ALSO FACILITATES THE ABILITY FOR MAYO CLINIC TO SHARE AND
EXPAND THE LATEST MEDICAL KNOWLEDGE AND INNOVATIVE LEARNING
OPPORTUNITIES WITH OTHERS OUTSIDE MAYO CLINIC.
ANOTHER INITIATIVE IMPLEMENTED THROUGH MAYO CLINIC COLLEGE OF MEDICINE
AND SCIENCE IS THE OFFICE OF APPLIED SCHOLARSHIP AND EDUCATION SCIENCE
(OASES). THIS INNOVATIVE OFFICE PROVIDES EXPERTISE AND SUPPORT IN
FACULTY DEVELOPMENT, EDUCATION EVALUATION AND PRINCIPLES AND PRACTICES
OF EDUCATION SCIENCE TO ENSURE THE HIGHEST QUALITY OF EDUCATION
DELIVERY WITHIN EACH OF THE SCHOOLS WITHIN THE COLLEGE. THE COLLEGE HAS
ALSO IMPLEMENTED AN ACADEMY OF EDUCATIONAL EXCELLENCE TO DEVELOP AND
RECOGNIZE EDUCATORS TO BETTER PREPARE LEARNERS TO ADVANCE SCIENCE, MEET
PATIENTS' NEEDS AND SERVE AS TRANSFORMATIVE LEADERS IN HEALTH CARE.
AS PART OF ITS MEDICAL EDUCATION MISSION, MAYO CLINIC SPONSORS MAYO
CLINIC PROCEEDINGS, A MONTHLY JOURNAL FOR PHYSICIANS AND OTHER MEDICAL
PERSONNEL. THE JOURNAL IS PUBLISHED TO PROMOTE THE BEST INTERESTS OF
PATIENTS BY ADVANCING THE KNOWLEDGE AND PROFESSIONALISM OF THE
PHYSICIAN COMMUNITY. MAYO CLINIC PROCEEDINGS IS A PEER-REVIEWED
CLINICAL JOURNAL IN GENERAL AND INTERNAL MEDICINE AND AMONG THE MOST
WIDELY READ AND HIGHLY CITED SCIENTIFIC PUBLICATIONS FOR PHYSICIANS.
MAYO CLINIC PROCEEDINGS HAS BEEN CONTINUOUSLY PUBLISHED SINCE 1926 AND
HAS AN IMPACT FACTOR OF 8.9, RANKING IT #20 OUT OF 167 JOURNALS IN THE
MEDICINE, GENERAL AND INTERNAL CATEGORY. MAYO CLINIC PROCEEDINGS'
CONTENT FOCUSES ON CLINICAL AND LABORATORY MEDICINE, HEALTH CARE POLICY
AND ECONOMICS, MEDICAL EDUCATION AND ETHICS, AND RELATED TOPICS.
232212 10-28-22 Schedule O (Form 990) 2022

130
ALL OF THESE EDUCATIONAL EFFORTS TO DISCOVER, DELIVER, EXPAND AND SHARE
MEDICAL KNOWLEDGE PROMOTE MAYO'S CLINIC'S ABILITY TO PERPETUATE THE
HIGHEST QUALITY AND SAFETY IN PATIENT CARE.
FORM 990, PART V, LINE 4B, LIST OF FOREIGN COUNTRIES:
GERMANY, CAYMAN ISLANDS, IRELAND, MEXICO,
UNITED KINGDOM
FORM 990, PART VI, SECTION A, LINE 1A:
BETWEEN MEETINGS OF MAYO CLINIC'S BOARD OF TRUSTEES, MAYO CLINIC'S BYLAWS
DELEGATE TO THE MAYO CLINIC BOARD OF GOVERNORS, AN EXECUTIVE COMMITTEE OF
THE BOARD OF TRUSTEES, BROAD AUTHORITY TO EXERCISE THE POWERS OF THE BOARD
OF TRUSTEES WITHIN CERTAIN LIMITATIONS OF TIME AND TOPIC.
FORM 990, PART VI, SECTION A, LINE 2:
THE FOLLOWING INDIVIDUAL(S) IS/ARE EMPLOYED BY A RELATED ORGANIZATION:
DAHLEN, DENNIS E.,
WILLIAMS M.D., AMY W.,
ZORN, CHRISTINA K.,
THIELEN M.D., KENT R.,
MURPHY, JOSHUA B.,
MENKOSKY, PAULA E.,
HUBERT, SHERRY L.,
GORMAN, PAUL A.,
FRANCIS, JAMES R.,
FARRUGIA M.D., GIANRICO,
BROWN, WILLIAM A.,
RESULTING IN A BUSINESS RELATIONSHIP WITH THE FOLLOWING INDIVIDUAL(S) WHO

232212 10-28-22 Schedule O (Form 990) 2022
131
IS/ARE ASSOCIATED WITH THE RELATED ORGANIZATION AS AN OFFICER, DIRECTOR, OR
TRUSTEE:
DUNN, AJANI N.,
MENKOSKY, PAULA E.,
OTLEY M.D., CLARK C.,
DAHLEN, DENNIS E.,
MURPHY, JOSHUA B.,
HUBERT, SHERRY L.,
GORMAN, PAUL A.,
FRANCIS, JAMES R.,
BROWN, WILLIAM A.,
DIDEHBAN, ROSHANAK,
HARA M.D., AMY K.,
FONSECA M.D., RAFAEL,
MENKOSKY, PAULA E.,
TRUSTEE:
DIDEHBAN, ROSHANAK,
HARA M.D., AMY K.,
FONSECA M.D., RAFAEL,
MENKOSKY, PAULA E.,
DUNN, AJANI N.,
MCLAUGHLIN M.D., SARAH A.,

232212 10-28-22 Schedule O (Form 990) 2022
132
TRUSTEE:
DUNN, AJANI N.,
MCLAUGHLIN M.D., SARAH A.,
THIELEN M.D., KENT R.,
**********************
DAHLEN, DENNIS E.,
MURPHY, JOSHUA B.,
HUBERT, SHERRY L.,
HAVE A BUSINESS RELATIONSHIP AS THEY SERVE AS AN OFFICER, DIRECTOR, OR
TRUSTEE OF MAYO HOLDING COMPANY, A RELATED TAXABLE ENTITY.
DAHLEN, DENNIS E.,
GORMAN, PAUL A.,
HAVE A BUSINESS RELATIONSHIP AS THEY SERVE AS AN OFFICER, DIRECTOR, OR
TRUSTEE OF MAYO INSURANCE COMPANY, LTD, A RELATED TAXABLE ENTITY.
BAKER JR., DOUGLAS M.
GERBERDING M.D., JULIE L.
SERVE AS AN OFFICER, DIRECTOR, OR TRUSTEE OF MAYO CLINIC AND HAVE A
BUSINESS RELATIONSHIP WITH MERCK AND CO.
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH AND OTHER RELATED
COMPANIES PROVIDE MANAGEMENT SERVICES TO THE ENTIRE SYSTEM OF ENTITIES

232212 10-28-22 Schedule O (Form 990) 2022
133
WHICH WOULD INCLUDE THE FILING ORGANIZATION.
SINCE THE ENTITIES ARE RELATED ORGANIZATIONS, COMPENSATION FOR THE
OFFICERS, DIRECTORS, KEY EMPLOYEES, AND HIGHEST COMPENSATED EMPLOYEES HAS
BEEN DISCLOSED IN PART VII AND SCHEDULE J AS REQUIRED.
ARTICLE III HAVING TO DO WITH THE MEETINGS OF TRUSTEES WAS AMENDED SO
ACTIONS MAY BE TAKEN WITHOUT A MEETING IF THE VOTES THAT WOULD BE REQUIRED
AT A MEETING ARE MADE BY ADDITIONAL METHODS TO INCLUDE AUTHENTICATED
WRITING AND MAIL.
ARTICLE IV HAVING TO DO WITH OFFICERS WAS AMENDED TO CHANGE THE TYPE OF
CORPORATE DOCUMENTS REQUIRED TO BE EXECUTED BY THE BOARD OF TRUSTEES AND
THE BOARD OF GOVERNORS ALONG WITH DEFINING WHICH OFFICERS MUST SIGN AND
EXECUTE THE DOCUMENTS.
ARTICLE V HAVING TO DO WITH COMMITTEES WAS AMENDED SO THAT CERTAIN
COMMITTEES ARE APPROVED BY THE GOVERNANCE & NOMINATING COMMITTEE VERSUS THE
MAJORITY OF THE BOARD OF TRUSTEES.
ARTICLE VI HAVING TO DO WITH MAYO CLINIC MIDWEST EXECUTIVE OPERATIONS TEAM
WAS AMENDED SO ACTIONS MAY BE TAKEN WITHOUT A MEETING IF THE VOTES THAT
WOULD BE REQUIRED AT A MEETING ARE MADE BY ADDITIONAL METHODS TO INCLUDE
AUTHENTICATED WRITING AND MAIL.
FORM 990, PART VI, SECTION B, LINE 11B:
THE FORM 990 IS PREPARED BY MAYO CORPORATE TAX. THE TAX RETURN GOES
232212 10-28-22 Schedule O (Form 990) 2022
134
THROUGH TWO LEVELS OF REVIEW WITHIN THE CORPORATE TAX UNIT AND IS REVIEWED
BY THE TAX DIRECTOR. IT IS THEN REVIEWED BY THE DIVISION CHAIR-ACCOUNTING,
CHAIR-FINANCIAL AND ACCOUNTING SERVICES, CHAIR-REVENUE CYCLE, CHIEF
INVESTMENT OFFICER, CHIEF FINANCIAL OFFICER AND CHIEF LEGAL OFFICER.
A COPY OF THE FORM 990 IS THEN PROVIDED TO EACH MEMBER OF MAYO CLINIC'S
GOVERNING BODY VIA US MAIL, E-MAIL, OR DISTRIBUTION AT A BOARD MEETING.
ALL QUESTIONS ARE ADDRESSED PRIOR TO FILING THE FORM 990.
FORM 990, PART VI, SECTION B, LINE 12C:
MAYO CLINIC AND ITS AFFILIATES HAVE A COMPREHENSIVE CONFLICT OF INTEREST
POLICY APPLICABLE TO ALL OF THE AFFILIATED ENTITIES AND TO ALL DIRECTORS,
OFFICERS, AND EMPLOYEES OF THOSE ENTITIES.
ALL CURRENT AND FORMER OFFICERS, DIRECTORS, TRUSTEES, KEY EMPLOYEES AND
HIGHEST COMPENSATED EMPLOYEES WHO WE ANTICIPATE WILL BE LISTED ON A FORM
990 ARE ASKED TO COMPLETE AN "ANNUAL TAX AND COMPLIANCE DISCLOSURE" FORM.
THIS INFORMATION IS REVIEWED BY BOTH THE CORPORATE TAX DEPARTMENT AND THE
OFFICE OF CONFLICT OF INTEREST REVIEW.
ALL DISCLOSURES OF CURRENT OR PROPOSED ACTIVITY THAT REQUIRE ACTION UNDER
THE POLICY ARE THE SUBJECT OF ONGOING REVIEW AND ACTION THROUGH THE OFFICE
OF CONFLICT OF INTEREST REVIEW AND THE CONFLICT OF INTEREST REVIEW BOARD.
INVOLVED INDIVIDUALS ARE INFORMED OF ALL REQUIRED ACTION.
MANY TYPES OF RELATIONSHIPS THAT COULD CREATE CONFLICTS OF INTEREST ARE
PROHIBITED. OTHER TYPES OF RELATIONSHIPS ARE PERMITTED SUBJECT TO
COMPLIANCE WITH THE MANAGEMENT PLAN ESTABLISHED BY THE CONFLICT OF INTEREST

232212 10-28-22 Schedule O (Form 990) 2022
135
REVIEW BOARD.
A COMMON MANAGEMENT STRATEGY FOR PERMITTED ACTIVITIES IS TO REQUIRE
BILATERAL RECUSAL AND APPROPRIATE DOCUMENTATION IN THE MINUTES OF MAYO
CLINIC (AND/OR AFFILIATE) AND THE OUTSIDE ENTITY.
ADDITIONAL CONFLICT OF INTEREST POLICIES AND PROCEDURES EXIST FOR CERTAIN
ENTITIES CONCERNING RESEARCH CONTRACTS AND OTHER TYPES OF POTENTIAL
CONFLICTS.
THIS POLICY APPLIES TO THE ORGANIZATION'S DISREGARDED ENTITIES.
FORM 990, PART VI, SECTION B, LINE 15B:
MAYO CLINIC AND ITS AFFILIATES HAVE A COORDINATED PROCESS FOR REVIEWING AND
APPROVING COMPENSATION AND BENEFITS FOR EXECUTIVE LEADERSHIP, CONSULTING
STAFF AND SENIOR ADMINISTRATIVE LEADERSHIP, ALONG WITH ALLIED HEALTH STAFF.
IN ADDITION TO ANY REVIEW AND APPROVAL THAT MAY TAKE PLACE AT THE LOCAL
ENTITY OR REGIONAL LEVEL, THE FOLLOWING INDEPENDENT APPROVAL PROCESS OCCURS
ANNUALLY PRIOR TO IMPLEMENTATION OF THE RESPECTIVE COMPENSATION INCREASE.
THE COMPENSATION AND BENEFITS OF THE CEO AND SEVERAL OTHER OFFICERS AND KEY
EMPLOYEES OF MAYO CLINIC AND MAYO CLINIC GROUP WERE REVIEWED AND APPROVED
BY THE PROCESS DESCRIBED BELOW.
THE COMPENSATION AND BENEFITS OF EXECUTIVE LEADERSHIP, CONSULTING STAFF AND
SENIOR ADMINISTRATIVE LEADERSHIP FOR ALL CAMPUSES, INCLUDING THE MAYO
CLINIC HEALTH SYSTEM LOCATIONS, ARE REVIEWED AND APPROVED BY THE MAYO
CLINIC BOARD OF TRUSTEES GOVERNANCE AND NOMINATING COMMITTEE.

232212 10-28-22 Schedule O (Form 990) 2022
136
THE MAYO CLINIC BOARD OF TRUSTEES GOVERNANCE AND NOMINATING COMMITTEE IS
COMPRISED OF NINE OF THE EXTERNAL INDEPENDENT MEMBERS OF THE MAYO CLINIC
BOARD OF TRUSTEES. THIS GROUP REVIEWS AND APPROVES THE COMPENSATION AND
BENEFIT PROGRAMS FOR EXECUTIVE LEADERSHIP, CONSULTING STAFF AND CERTAIN
SENIOR ADMINISTRATIVE LEADERSHIP FROM ALL CAMPUSES (INCLUDING ALL PERSONS
BELIEVED TO BE DISQUALIFIED PERSONS). THIS PROCESS ESTABLISHES ACCEPTABLE
RANGES FOR VARIOUS POSITIONS, LEVELS, AND SPECIALTIES. THE COMMITTEE USES
COMPARABILITY DATA (INCLUDING THIRD-PARTY BENCHMARKING SURVEYS) IN ITS
REVIEW AND DOCUMENTS DECISIONS IN ITS REVIEW AND DOCUMENTS DECISIONS IN ITS
MINUTES.
IN ADDITION, THE MAYO CLINIC BOARD OF TRUSTEES GOVERNANCE AND NOMINATING
COMMITTEE DIRECTLY RETAINS AN INDEPENDENT THIRD-PARTY COMPENSATION
CONSULTANT TO PROVIDE RELEVANT, CONTEMPORANEOUS BENCHMARK INFORMATION FOR A
SMALL GROUP OF EXECUTIVE LEADERSHIP AND SENIOR PHYSICIAN POSITIONS
(INCLUDING THE CEO) FOR WHICH AN INDIVIDUALIZED REVIEW AND RECOMMENDATION
IS MADE.
FORM 990, PART VI, LINE 17, LIST OF STATES RECEIVING COPY OF FORM 990:
AL,AK,AR,CA,CT,FL,GA,IL,IN,KS,KY,MD,MA,MI,MN,MS,NH,NJ,NY,NC,NM,OK,OR,PA,RI
TN,UT,VA,WV,WI,SD,SC,AZ,DE,HI,ID,IA,LA,ME,WA,WY,VT,TX,NE,NV,MO,MT
FORM 990, PART VI, SECTION C, LINE 19:
MAYO CLINIC'S ARTICLES OF INCORPORATION ARE AVAILABLE THROUGH THE SECRETARY
OF STATE'S OFFICE OR UPON REQUEST FROM MAYO CLINIC. BYLAWS AND OTHER
GOVERNANCE DOCUMENTS ARE AVAILABLE UPON REQUEST FOR PURPOSES THAT MAYO
CLINIC DEEMS APPROPRIATE.

232212 10-28-22 Schedule O (Form 990) 2022
137
THE CONFLICT OF INTEREST POLICY IS AVAILABLE ON MAYO CLINIC'S WEBSITE OR
UPON REQUEST.
MAYO CLINIC'S CONSOLIDATED FINANCIAL STATEMENTS AND FEDERAL FORM 990 ARE
AVAILABLE UPON REQUEST.
FORM 990, PART IX, LINE 11G, OTHER FEES:
I/C PURCHASED SERVICES :
PROGRAM SERVICE EXPENSES 588,649,715.
MANAGEMENT AND GENERAL EXPENSES 1,566,503.
FUNDRAISING EXPENSES 6,281,279.
TOTAL EXPENSES 596,497,497.
OTHER PURCHASED SERVICES :
PROGRAM SERVICE EXPENSES 249,102,826.
MANAGEMENT AND GENERAL EXPENSES 13,434,238.
FUNDRAISING EXPENSES 7,384,248.
TOTAL EXPENSES 269,921,312.
TOTAL OTHER FEES ON FORM 990, PART IX, LINE 11G, COL A 866,418,809.
FORM 990, PART XI, LINE 9, CHANGES IN NET ASSETS:
PENSION-POST RETIREMENT (PER FASB A 2,607,682,036.
LOSSES ON UNCOLLECTIBLE PLEDGES -13,087,799.
REFUNDS OF CONTRIBUTIONS -2,030.
TOTAL TO FORM 990, PART XI, LINE 9 2,594,592,207.
FORM 990, PART XII, LINE 2C, AUDIT PROCESS

232212 10-28-22 Schedule O (Form 990) 2022
138
THE OVERSIGHT OF THE AUDIT PROCESS OR THE PROCESS FOR SELECTING AN
AUDITOR HAS NOT CHANGED.
232212 10-28-22 Schedule O (Form 990) 2022

139
OMB No. 1545-0047
SCHEDULE R Related Organizations and Unrelated Partnerships
(Form 990) Complete if the organization answered "Yes" on Form 990, Part IV, line 33, 34, 35b, 36, or 37.
Attach to Form 990.
2022
Open to Public
Part I Identification of Disregarded Entities. Complete if the organization answered "Yes" on Form 990, Part IV, line 33.
(a) (b) (c) (d) (e) (f)

Name, address, and EIN (if applicable) Primary activity Legal domicile (state or Total income End-of-year assets Direct controlling
of disregarded entity foreign country) entity
JOHN E HERMAN HOME AND TREATMENT FACILITY,

LLC - 82-4183345, 200 FIRST STREET S.W., RESIDENTIAL RECOVERY AND
ROCHESTER, MN 55905 TREATMENT FACILITY MINNESOTA 13,324. 5,374,567.MAYO CLINIC
MAYO CLINIC COMMUNITY ACO, LLC - 83-0610557
200 FIRST STREET S.W. ACCOUNTABLE CARE
ROCHESTER, MN 55905 ORGANIZATION MINNESOTA 924,350. 145,562.MAYO CLINIC
MAYO COLLABORATIVE SERVICES, LLC -
41-1346366, 200 FIRST STREET S.W.,
ROCHESTER, MN 55905 REFERENCE LAB SERVICES MINNESOTA 878,567,013. 301,800,070.MAYO CLINIC
MC INTERNATIONAL, LLC - 83-2805059
200 FIRST STREET S.W.
ROCHESTER, MN 55905 CONTRACTING SERVICES MINNESOTA 2,292,221. 105,460,747.MAYO CLINIC
Identification of Related Tax-Exempt Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related tax-exempt
Part II
organizations during the tax year.
(a) (b) (c) (d) (e) (f) (g)
Section 512(b)(13)
Name, address, and EIN Primary activity Legal domicile (state or Exempt Code Public charity Direct controlling controlled
of related organization foreign country) section status (if section entity entity?
501(c)(3)) Yes No
BLOOMER LAKEVIEW, INC. - 39-1450617 MCHS--NORTHWEST
2110 DUNCAN ROAD WISCONSIN REGION,
BLOOMER, WI 54724 LOW INCOME HOUSING WISCONSIN 501(C)(3) 7 INC. X
CHARTERHOUSE, INC. - 41-1405254
ROCHESTER, MN 55905 RETIREMENT LIVING CENTER MINNESOTA 501(C)(3) 10 MAYO CLINIC X
DESTINATION MEDICAL CENTER EDA - 46-4893585
50 SOUTH SIXTH STREET, SUITE 1500
MINNEAPOLIS, MN 55402-1498 ECONOMIC DEVELOPMENT MINNESOTA 501(C)(3) 12-I MAYO CLINIC X
MAYO CLINIC AMBULANCE - 41-1917516
ROCHESTER, MN 55905 AMBULANCE SERVICE MINNESOTA 501(C)(3) 10 MFMER X
For Paperwork Reduction Act Notice, see the Instructions for Form 990. Schedule R (Form 990) 2022
232161 09-14-22 LHA 140

Schedule R (Form 990) MAYO CLINIC 41-6011702
Part I Continuation of Identification of Disregarded Entities
(a) (b) (c) (d) (e) (f)

Name, address, and EIN Primary activity Legal domicile (state or Total income End-of-year assets Direct controlling
of disregarded entity foreign country) entity
MC PROPERTY HOLDINGS, LLC - 84-3454849

ROCHESTER, MN 55905 REAL ESTATE MINNESOTA 0. 0.MAYO CLINIC
FRANKLIN HEATING STATION, LLC - 41-0264830
200 FIRST STREET SW
ROCHESTER, MN 55905 UTILITY MINNESOTA 986,342. 56,390,601.MAYO CLINIC
MCHS--DECORAH CLINIC PHYSICIANS, LLC -
41-1711329, 907 MONTGOMERY STREET, DECORAH,
IA 52101 PATIENT CARE - CLINIC WISCONSIN 12,094,540. 7,730,690.MAYO CLINIC
KAHG, LLC - 20-1276436
ROCHESTER, MN 55905 REAL ESTATE ARIZONA 0. 0.MAYO CLINIC
232221
04-01-22 141
Part II Continuation of Identification of Related Tax-Exempt Organizations
(a) (b) (c) (d) (e) (f) (g)

Section 512(b)(13)
of related organization foreign country) section status (if section entity organization?
501(c)(3)) Yes No
LUTHER LAKESIDE APARTMENTS, INC. - MCHS--NORTHWEST
39-1409024, PO BOX 1510, EAU CLAIRE, WI LOW INCOME HOUSING FOR WISCONSIN REGION,
54702 ELDERLY WISCONSIN 501(C)(3) 10 INC. X
MAYO CLINIC ARIZONA - 86-0800150
13400 EAST SHEA BOULEVARD
SCOTTSDALE, AZ 85259 HOSPITAL AND CLINIC ARIZONA 501(C)(3) 3 MAYO CLINIC X
MAYO CLINIC FLORIDA (A NONPROFIT
CORPORATION) - 59-0714831, 4500 SAN PABLO MAYO CLINIC
ROAD, JACKSONVILLE, FL 32224 HOSPITAL FLORIDA 501(C)(3) 3 JACKSONVILLE X
MAYO CLINIC HOSPITAL -- ROCHESTER -
41-0944601, 200 FIRST STREET S.W.,
ROCHESTER, MN 55905 HOSPITAL MINNESOTA 501(C)(3) 3 MAYO CLINIC X
MAYO CLINIC JACKSONVILLE - 59-3337028
4500 SAN PABLO ROAD
JACKSONVILLE, FL 32224 PATIENT CARE - CLINIC FLORIDA 501(C)(3) 7 MAYO CLINIC X
MAYO CLINIC STIFTUNG
60486 FRANKFURT AM MAIN
FRANKFURT, GERMANY FUNDRAISING FOUNDATION GERMANY MFMER X
MAYO FOUNDATION FOR MEDICAL EDUCATION AND
RESEARCH - 41-1506440, 200 FIRST STREET CHARITABLE, EDUCATIONAL &
S.W., ROCHESTER, MN 55905 SCIENTIFIC ACTIVITIES MINNESOTA 501(C)(3) 10 MAYO CLINIC X
MCHS--AUSTIN FOUNDATION - 30-0107471
1000 FIRST DRIVE N.W. MCHS--SOUTHEAST
AUSTIN, MN 55912 FUNDRAISING FOUNDATION MINNESOTA 501(C)(3) 12-I MINNESOTA REGION X
MCHS--FAIRMONT - 41-0760836
800 MEDICAL CENTER DRIVE, PO BOX 800 MCHS--SOUTHWEST
FAIRMONT, MN 56031 HOSPITAL AND CLINIC MINNESOTA 501(C)(3) 3 MINNESOTA REGION X
MCHS--FRANCISCAN MEDICAL CENTER, INC. -
39-0806374, 700 WEST AVE SOUTH, LA CROSSE,
WI 54601 HOSPITAL AND CLINIC WISCONSIN 501(C)(3) 3 MAYO CLINIC X
MCHS--LAKE CITY - 41-1906820
500 WEST GRANT STREET
LAKE CITY, MN 55041 HOSPITAL MINNESOTA 501(C)(3) 3 MAYO CLINIC X
MCHS--NORTHWEST WISCONSIN REGION, INC. -
39-0813418, 1221 WHIPPLE STREET, EAU CLAIRE,
WI 54703 HOSPITAL WISCONSIN 501(C)(3) 3 MAYO CLINIC X
232222
04-01-22 142
Part II Continuation of Identification of Related Tax-Exempt Organizations
(a) (b) (c) (d) (e) (f) (g)

Section 512(b)(13)
of related organization foreign country) section status (if section entity organization?
501(c)(3)) Yes No
MCHS--SOUTHEAST MINNESOTA REGION -
41-1404075, 1000 FIRST DRIVE N.W., AUSTIN,
MN 55912 HOSPITAL AND CLINIC MINNESOTA 501(C)(3) 3 MAYO CLINIC X
MCHS--SOUTHWEST MINNESOTA REGION -
41-1236756, 1025 MARSH STREET, MANKATO, MN
56001 HOSPITAL AND CLINIC MINNESOTA 501(C)(3) 3 MAYO CLINIC X
MCHS--ST. JAMES - 41-0797368
1101 MOULTON & PARSONS DR. PO BOX 460 MCHS--SOUTHWEST
ST. JAMES, MN 56081 HOSPITAL AND CLINIC MINNESOTA 501(C)(3) 3 MINNESOTA REGION X
ENGEBRETSON FAMILY CHARITABLE TRUST -
41-6445383, 6325 S RAINBOW BLVD STE 300, LAS
VEGAS, NV 89118 CHARITABLE TRUST MINNESOTA 501(C)(3) 12-II N/A X
HAZEL HUGHES CHARITABLE TRUST - 80-0030922
PO BOX 470
PETERSBURG, IL 62675 CHARITABLE TRUST ILLINOIS 501(C)(3) 12-III-FI N/A X
NAEVE HEALTH CARE FOUNDATION - 41-1989509
404 WEST FOUNTAIN ST
ALBERT LEA, MN 56007 FUNDRAISING FOUNDATION MINNESOTA 501(C)(3) 12-III-FI N/A X
THE HIRSH FAMILY FOUNDATION - 41-1749842
108 NORTH MAIN STREET
AUSTIN, MN 55912 FUNDRAISING FOUNDATION MINNESOTA 501(C)(3) 12-I N/A X
DREW FOUNDATION - 59-6669745
PO BOX 2578
JACKSONVILLE, FL 32203-2578 CHARITABLE TRUST FLORIDA 501(C)(3) 12-I N/A X
HORMEL FOUNDATION - 41-0694716
329 N MAIN ST SUITE 102L
AUSTIN, MN 55912 FUNDRAISING FOUNDATION MINNESOTA 501(C)(3) 12-I N/A X
232222
04-01-22 143
Schedule R (Form 990) 2022 MAYO CLINIC 41-6011702 Page 2
Part III Identification of Related Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related
organizations treated as a partnership during the tax year.
(a) (b) (c) (d) (e) (f) (g) (h) (i) (j) (k)
Legal
Name, address, and EIN Primary activity domicile Direct controlling Predominant income Share of total Share of Disproportionate Code V-UBI General or Percentage
of related organization (state or entity (related, unrelated, income end-of-year allocations?
amount in box managing ownership
foreign excluded from tax under assets 20 of Schedule partner?
country) sections 512-514) Yes No K-1 (Form 1065) Yes No
LATIGO PETROLEUM, LLC -

36-4767494, P.O. BOX 14230, OIL & GAS
ODESSA, TX 79768 EXPLORATION DE MAYO CLINIC UNRELATED 39,009,629. 81,495,426. X 21,430,128. X 65.00%
MAYO CLINIC HEALTHCARE, LLP

15 PORTLAND PLACE UNITED MAYO CLINIC
LONDON, UNITED KINGDOM HEALTHCARE KINGDOM (UK) LTD UNRELATED X N/A X
Part IV Identification of Related Organizations Taxable as a Corporation or Trust. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, because it had one or more related
organizations treated as a corporation or trust during the tax year.
(a) (b) (c) (d) (e) (f) (g) (h) (i)
Section
Name, address, and EIN Primary activity Legal domicile Direct controlling Type of entity Share of total Share of Percentage 512(b)(13)
of related organization (state or entity (C corp, S corp, income end-of-year ownership controlled
foreign entity?
country) or trust) assets
Yes No
MAYO CLINIC SUPPORT SERVICES, TEXAS -
47-1751102, 200 FIRST STREET S.W.,
ROCHESTER, MN 55905 HEALTH SERVICES TX MAYO CLINIC C CORP 24,179. 97,055. 100.00% X
MAYO CLINIC UK, LTD.
3 MORE LONDON RIVERSIDE UNITED
LONDON, UNITED KINGDOM INVESTMENT ACTIVITIES KINGDOM MAYO CLINIC C CORP -354,376. 53,564,506. 100.00% X
MAYO HOLDING COMPANY - 41-1578020
ROCHESTER, MN 55905 HOLDING COMPANY MN MAYO CLINIC C CORP 202,535. 52,722,196. 100.00% X
MAYO INSURANCE COMPANY, LTD.
200 FIRST STREET S.W. CAYMAN
ROCHESTER, MN 55905 SELF INSURANCE POOL ISLANDS MAYO CLINIC C CORP 31,086,198. 165,023,745. 100.00% X
RESOUNDANT, INC. - 46-1661978
421 1ST AVE SW, SUITE 204W MANUFACTURING MEDICAL
ROCHESTER, MN 55902 DEVICE COMPONENT MN MFMER C CORP X
232162 09-14-22 144 Schedule R (Form 990) 2022
Part IV Continuation of Identification of Related Organizations Taxable as a Corporation or Trust
(a) (b) (c) (d) (e) (f) (g) (h) (i)

Section
foreign entity?
Yes No
ROCHESTER AIRPORT COMPANY - 41-0506870
200 FIRST STREET S.W. MAYO HOLDING
ROCHESTER, MN 55905 AIRPORT MANAGEMENT MN COMPANY C CORP X
SUPERBLOCK 3 PROPERTY OWNERS ASSOCIATION -
86-0870505, 13400 E. SHEA BLVD, SCOTTSDALE, COMMERCIAL PROPERTY MAYO CLINIC
AZ 85259 OWNERS ASSOCIATION AZ ARIZONA C CORP X
THE STABILE BUILDING OWNERS' ASSOCIATION -
20-8994499, 200 FIRST STREET S.W., COMMERCIAL PROPERTY
ROCHESTER, MN 55905 OWNERS ASSOCIATION MN MAYO CLINIC C CORP 0. 0. 85.00% X
MC ALLIANCE, LTD. - 98-1527769 HEALTHCARE AND
200 FIRST STREET S.W. ADMINISTRATIVE CAYMAN MC
ROCHESTER, MN 55905 SERVICES ISLANDS INTERNATIONAL C CORP 29,105,852. 20,604,927. 100.00% X
MAYO CLINIC UK 2, LTD.
3 MORE LONDON RIVERSIDE UNITED MAYO CLINIC
LONDON, UNITED KINGDOM INVESTMENT ACTIVITIES KINGDOM UK, LTD. C CORP X
MC HEALTHCAE SERVICES INDIA PRIVATE LIMITED HEALTHCARE AND
1 WORLD TOWER, 10TH FLOOR, TOWER 2A & 2B, SENADMINISTRATIVE MC
MUMBIA, INDIA SERVICES INDIA INTERNATIONAL C CORP 0. 0. 99.00% X
CHARITABLE LEAD TRUST CHARITABLE TRUST CA MAYO CLINIC TRUST 1,461,972. 10,403,293. 89.00% X
PERPETUAL TRUST CHARITABLE TRUST LA MAYO CLINIC TRUST 140,910. 1,997,463. 100.00% X
PERPETUAL TRUST (2) CHARITABLE TRUST MA MAYO CLINIC TRUST X
PERPETUAL TRUST CHARITABLE TRUST MO MAYO CLINIC TRUST 0. 162,531. 100.00% X
CHARITABLE REMAINDER TRUST CHARITABLE TRUST AZ MAYO CLINIC TRUST 0. 142,609. 60.00% X
CHARITABLE REMAINDER TRUST CHARITABLE TRUST CO MAYO CLINIC TRUST 0. 782,871. 100.00% X
232224
04-01-22 145
(a) (b) (c) (d) (e) (f) (g) (h) (i)

Section
foreign entity?
Yes No
CHARITABLE REMAINDER TRUST (6) CHARITABLE TRUST FL MAYO CLINIC TRUST X
CHARITABLE REMAINDER TRUST CHARITABLE TRUST MA MAYO CLINIC TRUST 0. 184,019. 100.00% X
CHARITABLE REMAINDER TRUST (97) CHARITABLE TRUST MN MAYO CLINIC TRUST X
CHARITABLE REMAINDER TRUST (4) CHARITABLE TRUST NC MAYO CLINIC TRUST X
CHARITABLE REMAINDER TRUST (2) CHARITABLE TRUST NV MAYO CLINIC TRUST X
CHARITABLE REMAINDER TRUST CHARITABLE TRUST TX MAYO CLINIC TRUST 0. 162,531. 100.00% X
PERPETUAL TRUST CHARITABLE TRUST ND MFMER TRUST X
CHARITABLE REMAINDER TRUST CHARITABLE TRUST CO MFMER TRUST X
CHARITABLE REMAINDER TRUST CHARITABLE TRUST FL MFMER TRUST X
CHARITABLE REMAINDER TRUST CHARITABLE TRUST MI MFMER TRUST X
CHARITABLE REMAINDER TRUST (42) CHARITABLE TRUST MN MFMER TRUST X

MCHS--SOUTHWES
MINNESOTA
CHARITABLE REMAINDER TRUST (6) CHARITABLE TRUST MN REGION TRUST X
232224
04-01-22 146
(a) (b) (c) (d) (e) (f) (g) (h) (i)

Section
foreign entity?
Yes No
MCHS--NORTHWES
WISCONSIN
CHARITABLE REMAINDER TRUST CHARITABLE TRUST WI REGION, INC. TRUST X
232224
04-01-22 147
Part V Transactions With Related Organizations. Complete if the organization answered "Yes" on Form 990, Part IV, line 34, 35b, or 36.
Note: Complete line 1 if any entity is listed in Parts II, III, or IV of this schedule. Yes No
1 During the tax year, did the organization engage in any of the following transactions with one or more related organizations listed in Parts II-IV?
a Receipt of (i) interest, (ii) annuities, (iii) royalties, or (iv) rent from a controlled entity ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1a X
b Gift, grant, or capital contribution to related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1b X
c Gift, grant, or capital contribution from related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1c X
d Loans or loan guarantees to or for related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1d X
e Loans or loan guarantees by related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1e X
f Dividends from related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1f X

g Sale of assets to related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1g X
h Purchase of assets from related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1h X
i Exchange of assets with related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1i X
j Lease of facilities, equipment, or other assets to related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1j X
k Lease of facilities, equipment, or other assets from related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1k X

l Performance of services or membership or fundraising solicitations for related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1l X
m Performance of services or membership or fundraising solicitations by related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1m X
n Sharing of facilities, equipment, mailing lists, or other assets with related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1n X
o Sharing of paid employees with related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1o X
p Reimbursement paid to related organization(s) for expenses ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1p X

q Reimbursement paid by related organization(s) for expenses ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1q X
r Other transfer of cash or property to related organization(s) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1r X

s Other transfer of cash or property from related organization(s) •••••••••••••••••••••••••••••••••••••••••••••••••••••••• 1s X
2 If the answer to any of the above is "Yes," see the instructions for information on who must complete this line, including covered relationships and transaction thresholds.
(a) (b) (c) (d)
Name of related organization Transaction Amount involved Method of determining amount involved
type (a-s)
(1) CHARTERHOUSE, INC. A 17,083.GAAP
(2) CHARTERHOUSE, INC. N 95,106.GAAP
(3) CHARTERHOUSE, INC. P 77,035.GAAP
(4) CHARTERHOUSE, INC. Q 1,552,263.GAAP
(5) CHARTERHOUSE, INC. S 2,685,602.GAAP
(6) MAYO CLINIC AMBULANCE A 821,018.GAAP

232163 09-14-22 148 Schedule R (Form 990) 2022
Part V Continuation of Transactions With Related Organizations (Schedule R (Form 990), Part V, line 2)
(a) (b) (c) (d)

Name of other organization Transaction Amount involved Method of determining
type (a-s) amount involved
(7)MAYO CLINIC AMBULANCE P 6,818,436.GAAP
(8)MAYO CLINIC AMBULANCE Q 587,804.GAAP
(9)MAYO CLINIC AMBULANCE R 118,964.GAAP
(10)MAYO CLINIC AMBULANCE S 74,496.GAAP
(11)MAYO CLINIC ARIZONA A 23,120,573.GAAP
(12)MAYO CLINIC ARIZONA B 120,978,669.GAAP
(13)MAYO CLINIC ARIZONA C 103,136,198.GAAP
(14)MAYO CLINIC ARIZONA L 11,655,205.GAAP
(15)MAYO CLINIC ARIZONA N 5,960,102.GAAP
(16)MAYO CLINIC ARIZONA P 305,818.GAAP
(17)MAYO CLINIC ARIZONA Q 14,137,859.GAAP
(18)MAYO CLINIC ARIZONA R 379,309.GAAP
(19)MAYO CLINIC ARIZONA S 42,220,649.GAAP
(20)MAYO CLINIC FLORIDA A 7,426,629.GAAP
(21)MAYO CLINIC FLORIDA B 55,547.GAAP
(22)MAYO CLINIC FLORIDA L 3,122,732.GAAP
(23)MAYO CLINIC FLORIDA N 20,290,922.GAAP
(24)MAYO CLINIC FLORIDA P 2,124,161.GAAP
232225
04-01-22 149
(a) (b) (c) (d)

(7)MAYO CLINIC FLORIDA Q 23,268,474.GAAP
(8)MAYO CLINIC FLORIDA S 77,142.GAAP
(9)MAYO CLINIC HOSPITAL ROCHESTER C 1,000,034,867.GAAP
(10)MAYO CLINIC HOSPITAL ROCHESTER N 13,814,832.GAAP
(11)MAYO CLINIC HOSPITAL ROCHESTER P 18,599,170.GAAP
(12)MAYO CLINIC HOSPITAL ROCHESTER Q 159,215,270.GAAP
(13)MAYO CLINIC HOSPITAL ROCHESTER R 838,577.GAAP
(14)MAYO CLINIC HOSPITAL ROCHESTER S 3,536,853.GAAP
(15)MAYO CLINIC JACKSONVILLE A 13,701,778.GAAP
(16)MAYO CLINIC JACKSONVILLE B 102,484,136.GAAP
(17)MAYO CLINIC JACKSONVILLE C 119,428,543.GAAP
(18)MAYO CLINIC JACKSONVILLE L 8,424,175.GAAP
(19)MAYO CLINIC JACKSONVILLE M 3,766,309.GAAP
(20)MAYO CLINIC JACKSONVILLE N 28,846,081.GAAP
(21)MAYO CLINIC JACKSONVILLE P 1,133,192.GAAP
(22)MAYO CLINIC JACKSONVILLE Q 11,666,610.GAAP
(23)MAYO CLINIC JACKSONVILLE S 27,015,646.GAAP
(24)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH B 942,601.GAAP
232225
04-01-22 150
(a) (b) (c) (d)

(7)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH C 3,524,340.GAAP
(8)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH N 70,446,244.GAAP
(9)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH P 4,950,721,154.GAAP
(10)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Q 29,322,027.GAAP
(11)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH R 2,786,982.GAAP
(12)MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH S 13,667,188.GAAP
(13)MAYO HOLDING COMPANY R 202,535.GAAP
(14)MCHS AUSTIN FOUNDATION B 53,428.GAAP
(15)MCHS FAIRMONT A 997,911.GAAP
(16)MCHS FAIRMONT B 2,034,091.GAAP
(17)MCHS FAIRMONT L 626,733.GAAP
(18)MCHS FAIRMONT N 1,570,696.GAAP
(19)MCHS FAIRMONT Q 860,944.GAAP
(20)MCHS FAIRMONT S 88,366.GAAP
(21)MCHS FRANCISCAN MEDICAL CENTER, INC. A 4,606,794.GAAP
(22)MCHS FRANCISCAN MEDICAL CENTER, INC. B 274,557.GAAP
(23)MCHS FRANCISCAN MEDICAL CENTER, INC. C 1,890,115.GAAP
(24)MCHS FRANCISCAN MEDICAL CENTER, INC. L 3,727,817.GAAP
232225
04-01-22 151
(a) (b) (c) (d)

(7)MCHS FRANCISCAN MEDICAL CENTER, INC. N 5,123,161.GAAP
(8)MCHS FRANCISCAN MEDICAL CENTER, INC. P 88,312.GAAP
(9)MCHS FRANCISCAN MEDICAL CENTER, INC. Q 9,446,704.GAAP
(10)MCHS FRANCISCAN MEDICAL CENTER, INC. S 145,622.GAAP
(11)MCHS LAKE CITY A 460,522.GAAP
(12)MCHS LAKE CITY B 95,798.GAAP
(13)MCHS LAKE CITY L 178,705.GAAP
(14)MCHS LAKE CITY N 269,840.GAAP
(15)MCHS LAKE CITY Q 464,464.GAAP
(16)MCHS LAKE CITY R 189,871.GAAP
(17)MCHS NORTHWEST WISCONSIN REGION, INC. A 12,648,107.GAAP
(18)MCHS NORTHWEST WISCONSIN REGION, INC. B 2,099,380.GAAP
(19)MCHS NORTHWEST WISCONSIN REGION, INC. C 60,657,177.GAAP
(20)MCHS NORTHWEST WISCONSIN REGION, INC. L 5,161,233.GAAP
(21)MCHS NORTHWEST WISCONSIN REGION, INC. M 70,358.GAAP
(22)MCHS NORTHWEST WISCONSIN REGION, INC. N 3,363,654.GAAP
(23)MCHS NORTHWEST WISCONSIN REGION, INC. P 351,722.GAAP
(24)MCHS NORTHWEST WISCONSIN REGION, INC. Q 18,094,859.GAAP
232225
04-01-22 152
(a) (b) (c) (d)

(7)MCHS NORTHWEST WISCONSIN REGION, INC. S 988,118.GAAP
(8)MCHS SOUTHEAST MINNESOTA REGION A 7,795,084.GAAP
(9)MCHS SOUTHEAST MINNESOTA REGION B 14,562,989.GAAP
(10)MCHS SOUTHEAST MINNESOTA REGION C 15,208,399.GAAP
(11)MCHS SOUTHEAST MINNESOTA REGION L 5,233,471.GAAP
(12)MCHS SOUTHEAST MINNESOTA REGION N 6,620,601.GAAP
(13)MCHS SOUTHEAST MINNESOTA REGION Q 13,973,226.GAAP
(14)MCHS SOUTHWEST MINNESOTA REGION A 8,063,512.GAAP
(15)MCHS SOUTHWEST MINNESOTA REGION B 4,340,198.GAAP
(16)MCHS SOUTHWEST MINNESOTA REGION C 2,790,006.GAAP
(17)MCHS SOUTHWEST MINNESOTA REGION L 4,455,217.GAAP
(18)MCHS SOUTHWEST MINNESOTA REGION M 78,473.GAAP
(19)MCHS SOUTHWEST MINNESOTA REGION N 6,133,462.GAAP
(20)MCHS SOUTHWEST MINNESOTA REGION P 60,835.GAAP
(21)MCHS SOUTHWEST MINNESOTA REGION Q 12,377,886.GAAP
(22)MCHS SOUTHWEST MINNESOTA REGION S 73,966.GAAP
(23)MCHS ST. JAMES L 139,901.GAAP
(24)MCHS ST. JAMES N 533,482.GAAP
232225
04-01-22 153
(a) (b) (c) (d)

(7) MCHS ST. JAMES Q 297,267.GAAP
(8) MCHS ST. JAMES R 273,399.GAAP
(9) RESOUNDANT, INC. P 135,360.GAAP
(10)
(11)
(12)
(13)
(14)
(15)
(16)
(17)
(18)
(19)
(20)
(21)
(22)
(23)
(24)
232225
04-01-22 154
Part VI Unrelated Organizations Taxable as a Partnership. Complete if the organization answered "Yes" on Form 990, Part IV, line 37.
Provide the following information for each entity taxed as a partnership through which the organization conducted more than five percent of its activities (measured by total assets or gross revenue)
that was not a related organization. See instructions regarding exclusion for certain investment partnerships.
(a) (b) (c) (d) (e) (f) (g) (h) (i) (j) (k)
Are all
Name, address, and EIN Primary activity Legal domicile Predominant income partners sec. Share of Share of Dispropor-Code V-UBI General or Percentage
of entity (state or foreign (related, unrelated, 501(c)(3)
total end-of-year amount in box 20 managing ownership
tionate
excluded from tax under orgs.? of Schedule K-1 partner?
allocations?
country) sections 512-514) Yes No income assets Yes No (Form 1065) Yes No
Schedule R (Form 990) 2022
232164 09-14-22 155

Part VII Supplemental Information
Provide additional information for responses to questions on Schedule R. See instructions.
232165 09-14-22 Schedule R (Form 990) 2022

156
Mayo Clinic
Consolidated Financial Report
Years Ended December 31, 2022 and 2021
Mayo Clinic
Contents
Independent auditor's report 2
Consolidated financial statements
Consolidated statements of financial position 5
Consolidated statements of activities 6
Consolidated statements of cash flows 7
Notes to consolidated financial statements 8

Ernst & Young LLP Tel: +1 612 343 1000
Suite 500 ey.com
700 Nicollet Mall
Minneapolis, MN 55402
Report of Independent Auditors
Board of Trustees
Mayo Clinic
Opinion
We have audited the consolidated financial statements of Mayo Clinic (“the Clinic”), which
comprise the consolidated statements of financial position as of December 31, 2022 and 2021, and
the related consolidated statements of activities and cash flows for the years then ended, and the
related notes (collectively referred to as the “financial statements”).
In our opinion, the accompanying financial statements present fairly, in all material respects, the
financial position of the Clinic at December 31, 2022 and 2021, and the results of its operations
and its cash flows for the years then ended in accordance with accounting principles generally
accepted in the United States of America.
Basis for Opinion
We conducted our audits in accordance with auditing standards generally accepted in the United
States of America (GAAS). Our responsibilities under those standards are further described in the
Auditor’s Responsibilities for the Audit of the Financial Statements section of our report. We are
required to be independent of the Clinic and to meet our other ethical responsibilities in accordance
with the relevant ethical requirements relating to our audits. We believe that the audit evidence we
have obtained is sufficient and appropriate to provide a basis for our audit opinion.
Responsibilities of Management for the Financial Statements
Management is responsible for the preparation and fair presentation of the financial statements in
accordance with accounting principles generally accepted in the United States of America, and for
the design, implementation, and maintenance of internal control relevant to the preparation and
fair presentation of financial statements that are free of material misstatement, whether due to fraud
or error.
In preparing the financial statements, management is required to evaluate whether there are
conditions or events, considered in the aggregate, that raise substantial doubt about the Clinic’s
ability to continue as a going concern for one year after the date that the financial statements are
issued.
2302-4193470 2
A member firm of Ernst & Young Global Limited
Auditor’s Responsibilities for the Audit of the Financial Statements
Our objectives are to obtain reasonable assurance about whether the financial statements as a whole
are free of material misstatement, whether due to fraud or error, and to issue an auditor’s report
that includes our opinion. Reasonable assurance is a high level of assurance but is not absolute
assurance and therefore is not a guarantee that an audit conducted in accordance with GAAS will
always detect a material misstatement when it exists. The risk of not detecting a material
misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve
collusion, forgery, intentional omissions, misrepresentations, or the override of internal control.
Misstatements are considered material if there is a substantial likelihood that, individually or in
the aggregate, they would influence the judgment made by a reasonable user based on the financial
statements.
In performing an audit in accordance with GAAS, we:
• Exercise professional judgment and maintain professional skepticism throughout the audit.
• Identify and assess the risks of material misstatement of the financial statements, whether
due to fraud or error, and design and perform audit procedures responsive to those risks.
Such procedures include examining, on a test basis, evidence regarding the amounts and
disclosures in the financial statements.
• Obtain an understanding of internal control relevant to the audit in order to design audit
procedures that are appropriate in the circumstances, but not for the purpose of expressing
an opinion on the effectiveness of the Clinic’s internal control. Accordingly, no such
opinion is expressed.
• Evaluate the appropriateness of accounting policies used and the reasonableness of

significant accounting estimates made by management, as well as evaluate the overall
presentation of the financial statements.
• Conclude whether, in our judgment, there are conditions or events, considered in the
aggregate, that raise substantial doubt about the Clinic’s ability to continue as a going
concern for a reasonable period of time.
We are required to communicate with those charged with governance regarding, among other
matters, the planned scope and timing of the audit, significant audit findings, and certain internal
control-related matters that we identified during the audit.
2302-4193470 3
Other Information
Management is responsible for the other information. The other information comprises the
Management Discussion and Analysis but does not include the financial statements and our
auditor’s report thereon. Our opinion on the financial statements does not cover the other
information, and we do not express an opinion or any form of assurance thereon.
In connection with our audit of the financial statements, our responsibility is to read the other
information and consider whether a material inconsistency exists between the other information
and the financial statements, or the other information otherwise appears to be materially misstated.
If, based on the work performed, we conclude that an uncorrected material misstatement of the
other information exists, we are required to describe it in our report.

February 17, 2023
2302-4193470 4
Consolidated Statements of Financial Position
December 31, 2022 and 2021 (In Millions)
2022 2021
Assets
Current assets:
Cash and cash equivalents $ 64 $ 46
Accounts receivable for medical services 1,842 1,826
Other receivables 759 648
Other current assets 386 317
Total current assets 3,051 2,837
Investments 17,256 18,021

Other long-term assets 3,631 1,407
Property, plant, and equipment, net 5,887 5,410
Total assets $ 29,825 $ 27,675
Liabilities and net assets
Current liabilities:
Accounts payable $ 752 $ 768
Accrued payroll 849 818
Accrued employee benefits 176 168
Deferred revenue 64 62
Long-term variable-rate debt 620 620
Other current liabilities 470 509
Total current liabilities 2,931 2,945
Long-term debt, net of current portion 4,121 3,552

Accrued pension and postretirement benefits, net of current portion 819 1,378
Other long-term liabilities 2,083 2,133
Total liabilities 9,954 10,008
Net assets:
Without donor restrictions 14,808 12,431
With donor restrictions 5,063 5,236
Total net assets 19,871 17,667
Total liabilities and net assets $ 29,825 $ 27,675
See notes to consolidated financial statements.
5
Consolidated Statements of Activities
Years Ended December 31, 2022 and 2021 (In Millions)
2022 2021
Without With Without With
Donor Donor Donor Donor
Restrictions Restrictions Total Restrictions Restrictions Total
Revenue, gains, and other support:
Medical service revenue $ 13,781 $ — $ 13,781 $ 13,310 $ — $ 13,310
Grants and contracts 666 — 666 613 — 613
Investment return allocated to current activities 250 23 273 217 24 241
Contributions available for current activities 75 268 343 181 253 434
Other 1,227 — 1,227 1,131 — 1,131
Net assets released from restrictions 337 (337) — 430 (430) —
Total revenue, gains, and other support 16,336 (46) 16,290 15,882 (153) 15,729
Expenses:
Salaries and benefits 9,170 — 9,170 8,661 — 8,661
Supplies and services 5,377 — 5,377 4,767 — 4,767
Depreciation and amortization 624 — 624 619 — 619
Facilities 350 — 350 326 — 326
Finance and investment 174 — 174 144 — 144
Total expenses 15,695 — 15,695 14,517 — 14,517
Income (loss) from current activities 641 (46) 595 1,365 (153) 1,212
Noncurrent and other items:

Contributions not available for current activities, net (22) 230 208 (22) 371 349
Unallocated investment return, net (1,382) (357) (1,739) 1,432 669 2,101
Income tax expense (23) — (23) (25) — (25)
Benefit credit 175 — 175 61 — 61
Other 129 — 129 (124) — (124)
Total noncurrent and other items (1,123) (127) (1,250) 1,322 1,040 2,362
Increase (decrease) in net assets before other

changes in net assets (482) (173) (655) 2,687 887 3,574
Pension and other postretirement benefit adjustments 2,859 — 2,859 1,728 — 1,728
Increase (decrease) in net assets 2,377 (173) 2,204 4,415 887 5,302
Net assets at beginning of year 12,431 5,236 17,667 8,016 4,349 12,365
Net assets at end of year $ 14,808 $ 5,063 $ 19,871 $ 12,431 $ 5,236 $ 17,667
6
Consolidated Statements of Cash Flows
Years Ended December 31, 2022 and 2021 (In Millions)
2022 2021
Cash flows from operating activities:
Cash from medical services $ 12,827 $ 12,283
Cash from external lab services 938 957
Cash from grants and contracts 658 616
Cash from benefactors 345 368
Cash from other activities 1,140 1,030
Cash for salaries and benefits (8,822) (8,350)
Cash for supplies, services, and facilities (5,798) (5,136)
Interest and dividends received 196 222
Interest paid (144) (126)
Income taxes paid (33) (63)
Net cash provided by operating activities 1,307 1,801
Cash flows from investing activities:

Purchase of property, plant, and equipment (1,177) (861)
Purchases of investments (7,711) (6,832)
Sales and maturities from investments 6,838 5,291
Investment in unconsolidated entities (10) (43)
Net cash used in investing activities (2,060) (2,445)
Cash flows from financing activities:

Restricted gifts, bequests, and other 208 265
Borrowing on long-term debt 807 500
Payment of long-term debt (237) (141)
Payment on leases (7) (6)
Net cash provided by financing activities 771 618
Net increase (decrease) in cash and cash equivalents 18 (26)
Cash and cash equivalents at beginning of year 46 72
Cash and cash equivalents at end of year $ 64 $ 46
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Mayo Clinic
Notes to Consolidated Financial Statements (In Millions)
Note 1. Organization and Summary of Significant Accounting Policies

Organization: Mayo Clinic and its Arizona, Florida, Iowa, Minnesota, Wisconsin and international
affiliates (the Clinic) provide comprehensive medical care and education in clinical medicine and medical
sciences and conduct extensive programs in medical research. The Clinic also provides hospital and
outpatient services, and at each major location, the clinical practice is closely integrated with advanced
education and research programs. The Clinic and most of its subsidiaries have been determined to qualify
as tax-exempt organizations under Section 501(c)(3) of the Internal Revenue Code (the Code) and as a
public charity under Section 509(a)(2) of the Code.
Basis of presentation: Included in the Clinic’s consolidated financial statements are all of its wholly
owned or wholly controlled subsidiaries. All significant intercompany transactions have been eliminated in
consolidation. In addition, these statements follow generally accepted accounting principles applicable to
the not-for-profit industry as described in the Financial Accounting Standards Board (FASB) Accounting
Standards Codification (ASC) Topic 958, Not-for Profit Entities.
Use of estimates: The preparation of financial statements in conformity with U.S. generally accepted
accounting principles (GAAP) requires management to make estimates and assumptions that affect the
reported amounts of assets and liabilities at the date of the financial statements. Estimates also affect the
reported amounts of revenue and expenses during the reporting period. Actual results could differ from
those estimates.
New Accounting Standards:
Effective January 1, 2022, the Clinic adopted FASB Accounting Standards Update (ASU) No. 2020-07,
Presentation and Disclosures by Not-for-Profit Entities for Contributed Nonfinancial Assets (Topic 958).
This ASU required presentation of contributed nonfinancial assets as a separate line in the consolidated
statement of activities, apart from contributions of cash or other financial assets. The adoption of this ASU
did not materially impact the consolidated financial statements.
Cash and cash equivalents: Cash and cash equivalents include currency on hand, demand deposits
with banks or other financial institutions, and short-term investments with maturities of three months or
less from the date of purchase, which are not managed by the Clinic’s investment managers.
Accounts receivable for medical services: Accounts receivable for medical services are based upon
the estimated amounts expected to be paid from patients and third-party payors.
Inventories: Inventories, consisting primarily of medical supplies and pharmaceuticals, are stated at the
lower of cost or net realizable value.
Investments: Investments in equity and debt securities, including alternative investments, are recorded
at fair value (Notes 4 and 6). Fair value is the price that would be received to sell an asset or paid to
transfer a liability in an orderly transaction between market participants at the measurement date.
Realized gains and losses are calculated based on the average cost method. Investment income or loss
(including realized and unrealized gains and losses on investments, interest, and dividends) is included in
the consolidated statements of activities.
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Mayo Clinic
Note 1. Organization and Summary of Significant Accounting Policies (Continued)
Alternative investments (principally limited partnership interests in absolute return, hedge, private equity,
real estate and natural resources funds) represent the Clinic’s ownership interest in the respective
partnership, which is valued at fair value based on net asset value (NAV) obtained from fund manager
statements and historically audited financial statements. The investments in alternative investments may
individually expose the Clinic to securities lending, short sales, and trading in futures and forward contract
options and other derivative products. The Clinic’s risk is limited to the investment’s carrying value.
It is the Clinic’s intent to maintain a long-term investment portfolio to support research, education and
other activities. Accordingly, the total investment return is reported in the consolidated statements of
activities in two categories. The investment return allocated to current activities is determined by a
formula, which involves allocating five percent of a three-year moving average of investments related to
endowments, and the matching of financing costs for the assets required for operations. Management
believes this return is approximately equal to the real return that the Clinic expects to earn on its
investments over the long term. The unallocated investment return, included in noncurrent and other
items in the consolidated statements of activities, represents the difference between the total investment
return and the amount allocated to current activities, net of investment costs.
Property, plant, and equipment: Property, plant, and equipment are carried at cost if purchased or at
fair value on the date received through affiliation or donation, less accumulated depreciation. Plant and
equipment are depreciated over their estimated useful lives, ranging from three to fifty years using the
straight-line method. Depreciation expense includes amortization of assets recorded under capital leases.
Costs associated with the development and installation of internal-use software are accounted for in
accordance with Intangibles—Goodwill and Other, Internal-Use Software (Subtopic 350-40) of the FASB
ASC. Accordingly, internal-use software costs are expensed or capitalized and amortized according to the
provisions of the accounting standard.
Leases: The Clinic determines if an arrangement is a lease at inception. Operating leases are included
in other long-term assets, other current liabilities, and other long-term liabilities in the consolidated
statements of financial position. Finance leases are included in property, plant, and equipment, other
current liabilities, and other long-term liabilities in the consolidated statements of financial position.
Right-of-use (ROU) assets represent the right to use an underlying asset for the lease term, and lease
liabilities represent the obligation to make lease payments arising from the lease. ROU assets and
liabilities are recognized at the commencement date, based on the present value of lease payments over
the lease term. As most of the leases do not provide an implicit rate, the Clinic uses an incremental
borrowing rate based on the information available at the commencement date in determining the present
value of lease payments. The implicit rate is used when readily determinable. The ROU asset also
includes any lease payments made and excludes lease incentives. The lease term may include options to
extend or terminate the lease when it is reasonably certain the Clinic will exercise the option.
The Clinic defines a short-term lease as any lease arrangement with a lease term of twelve months or
less that does not include an option to purchase the underlying asset. Short-term lease payments are
recognized as expense on a straight-line basis over the lease term and variable lease payments in the
period in which the obligation is incurred.
The Clinic has lease arrangements with lease and non-lease components, which are generally accounted
for separately, except the Clinic has elected the practical expedient to not separate non-lease
components for real estate leases. Additionally, for certain equipment leases, the Clinic applies a portfolio
approach to effectively account for the ROU assets and liabilities.
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Mayo Clinic
Note 1. Organization and Summary of Significant Accounting Policies (Continued)
Deferred revenue: Deferred revenue consists of payments received in advance for grant, subscription,
and tuition revenue. Deferred revenues are subsequently recognized as revenue in accordance with the
Clinic’s revenue recognition policies.
Deferred compensation: The Clinic offers eligible employees a nonqualified, tax-deferred compensation
retirement plan. Employees defer compensation into the plan on a pretax basis. The compensation
deferred under this plan is credited with earnings and losses as determined by the rate of return on
investments selected by the plan participants. Each participant is fully vested in all deferred
compensation and those earnings credited to their individual accounts. The amounts deferred under this
plan is an unsecured obligation of the Clinic. The balances are reflected in investments and other long-
term liabilities in the consolidated statements of financial position. The related investment return is
reported in unallocated investment return, net, with a corresponding gain/loss representing benefit
expense/income reported in the other - noncurrent section of the consolidated statements of activities.
Asset retirement obligations: The Clinic accounts for the estimated cost of legal obligations associated
with long-lived asset retirements in accordance with Asset Retirement and Environmental Obligations
(Topic 410) of the FASB ASC. The asset retirement liability, recorded in other long-term liabilities, is
accreted to the present value of the estimated future costs of these obligations at the end of each period.
Net assets: Net assets, revenues, gains, and losses are classified based on the existence or absence of
donor or grantor-imposed restrictions. Accordingly, net assets and changes therein are classified and
reported as follows:
Net Assets Without Donor Restrictions - Net assets available for use in general operations and not
subject to donor restrictions. The governing board has designated, from net assets without donor
restrictions, net assets for an operating reserve and board-designated endowment.
Net Assets With Donor Restrictions - Net assets subject to donor-imposed restrictions. Some donor-
imposed restrictions are temporary in nature, such as those that will be met by the passage of time or
other events specified by the donor. Other donor-imposed restrictions are perpetual in nature, where the
donor stipulates that resources be maintained in perpetuity. Gifts of long-lived assets and gifts of cash
restricted for the acquisition on long-lived assets are recognized as revenue when received. Donor-
imposed restrictions are released when a restriction expires, that is, when the stipulated time has
elapsed, when the stipulated purpose for which the resource was restricted has been fulfilled, or both.
Medical service revenue: Medical service revenue is reported at the amount that reflects the
consideration to which the Clinic expects to be entitled in exchange for providing patient care.
Grants and contracts: Reciprocal grants and contracts revenue is recognized when the expenses have
been incurred for the purpose specified by the grantor or in accordance with the terms of the agreement.
Contributed grants and contracts revenue is recorded as conditions are met or immediately if deemed an
unconditional contribution. Grant and contract amounts due to the Clinic are included in other receivables.
Charity and uncompensated care: The Clinic provides health care services to patients who meet
certain criteria under its Charity Care Policy without charge or at amounts less than established rates.
Since the Clinic does not pursue collection of these amounts, they are not reported as revenue. The
estimated cost of providing these services was $54 and $49 in 2022 and 2021, respectively, calculated by
multiplying the ratio of cost to gross charges for the Clinic by the gross uncompensated charges
associated with providing care to charity patients. In addition to the charges related to the direct patient
care provided under the Clinic’s Charity Care Policy, the Clinic has programs offered to benefit the
broader community and other governmental reimbursement programs. The Clinic also participates in
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Mayo Clinic
Note 1. Organization and Summary of Significant Accounting Policies (Continued
various state Medicaid programs for indigent patients. The estimated unreimbursed cost of providing
services related to Medicaid programs totaled $613 and $601 in 2022 and 2021, respectively.
Contributions: The Clinic classifies contributions that are available for current activities as revenue,
based on the lack of specific donor restriction or the presence of donor restrictions and the ability of the
Clinic to meet those restrictions within the year. Contributions of a perpetual nature or not available for
current activities are classified in noncurrent and other items in the consolidated statements of activities.
Development expenses of $54 ($32 allocated to current and $22 allocated to noncurrent) and $48 ($26
allocated to current and $22 allocated to noncurrent) were incurred in 2022 and 2021, respectively. The
current portion is recorded in expenses, and the noncurrent portion is netted against contributions not
available for current activities in the consolidated statements of activities. Unconditional promises to give
and contributions are reported at fair value at the time of the gift. An allowance for uncollectible pledges
receivable is estimated, based on a combination of historical experience and specific identification.
Conditional promises to give are recognized at fair value when the barriers to entitlement are overcome or
the possibility that a condition will not be met is remote.
The Clinic periodically receives works of art from various benefactors. These items are unique in nature
and are held on display for the benefit and enjoyment of the Clinic’s patients. It is the Clinic’s policy to
neither capitalize contributed works of art nor record the related contribution revenue.
Income from current activities: The Clinic’s policy is to include in income from current activities all
medical service and other revenue, grants and contracts, investment return allocated to current activities,
contributions available for current activities, net assets released from restrictions, and substantially all
expenses. Contributions not available for current activities, unallocated investment return, income tax
expense, benefit credit, and those items not expected to recur on a regular basis are included in
noncurrent and other items in the consolidated statements of activities.
Noncontrolling interest in subsidiaries: The Clinic attributed income of $33 and $9 for the years
ended December 31, 2022 and 2021, respectively, to noncontrolling interests based on the ownership
percentage of the noncontrolling interests in certain of the Clinic’s consolidated subsidiaries. These
amounts are recognized in net assets without donor restrictions on the consolidated statements of
financial position. The balance in net assets without donor restrictions as of December 31, 2022 and 2021
was $68 and $36, respectively.
Subsequent events: The Clinic evaluated events and transactions occurring subsequent to December
31, 2022 through February 17, 2023, the date of issuance of the consolidated financial statements. During
this period, there were no subsequent events requiring recognition in the consolidated financial
statements. Additionally, there were no unrecognized events requiring disclosure.
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Mayo Clinic
Note 2. Liquidity and Availability
Financial assets available for general expenditure within one year of the consolidated statement of
financial position date are composed of the following at December 31:
2022 2021
Cash and cash equivalents $ 64 $ 46
Accounts receivable 1,842 1,826
Promises to give 319 294
Grants receivable 145 134
Other receivables 295 220
Investments 10,495 11,234
Total financial assets available within one year $ 13,160 $ 13,754
As part of a liquidity management plan, the Clinic has a policy to structure its financial assets to be
available as its general expenditures, liabilities, and other obligations come due. Cash in excess of daily
requirements is invested in short-term investments. In the event of an unanticipated liquidity need, the
Clinic has $300 of available lines of credit for working capital (see Note 9 - Financing).
The Clinic's endowment funds consist of donor-restricted endowments and funds designated by the board
as endowment. Income from endowments is restricted for specific purposes. As described in Note 13 -
Endowment, under the Clinic spending policy, $280 from the endowments was available as of January 1,
2023 and $247 from the endowments was available at January 1, 2022.
Note 3. Medical Service Revenue

Medical service revenue is reported at the amount that reflects the consideration to which the Clinic
expects to be entitled in exchange for providing patient care. These amounts, representing transaction
price, are due from patients, third-party payors (including health insurers and government programs), and
others and include variable consideration for retroactive revenue adjustments due to settlement of audits,
reviews, and investigations. Generally, the Clinic bills the patients and third-party payors several days
after the services are performed and/or the patient is discharged from the facility. Revenue is recognized
as performance obligations are satisfied.
Performance obligations are determined based on the nature of the services provided by the Clinic.
Revenue for performance obligations satisfied over time is recognized based on actual charges incurred
in relation to total expected (or actual) charges. The Clinic believes that this method provides a faithful
depiction of the transfer of services over the term of the performance obligation based on the inputs
needed to satisfy the obligation. Generally, performance obligations satisfied over time relate to patients
in the Clinic's hospital receiving inpatient acute care services. The Clinic measures the performance
obligation from admission into the hospital to the point when it is no longer required to provide services to
that patient, which is generally at the time of discharge. Revenue for performance obligations satisfied at
a point in time is recognized when goods or services are provided and the Clinic does not believe it is
required to provide additional goods or services to the patient.
Because all of its performance obligations relate to contracts with a duration of less than one year, the
Clinic has elected to apply the optional exemption provided in Revenue from Contracts with Customers
(Topic 606-10-50-14(a)) and, therefore, is not required to disclose the aggregate amount of the
12
Mayo Clinic
Note 3. Medical Service Revenue (Continued)

transaction price allocated to performance obligations that are unsatisfied or partially unsatisfied at the
end of the reporting period. The unsatisfied or partially unsatisfied performance obligations referred to
above are primarily related to inpatient acute care services at the end of the reporting period. The
performance obligations for these contracts are generally completed when the patients are discharged,
which generally occurs within days or weeks of the end of the reporting period.
The Clinic determines the transaction price based on standard charges for goods and services provided
to patients, reduced by contractual adjustments provided to third-party payors, discounts provided to
uninsured patients in accordance with the Clinic’s policy, and/or implicit price concessions based on
historical collection experience.
Agreements with third-party payors typically provide for payments at amounts less than established
charges. A summary of the payment arrangements with major third-party payors follows:
• Medicare: Certain inpatient acute care services are paid at prospectively determined rates per
discharge based on clinical, diagnostic, and other factors. Certain services are paid based on
cost-reimbursement methodologies subject to certain limits. Physician services are paid based
upon established fee schedules. Outpatient services are paid using prospectively determined
rates.
• Medicaid: Reimbursements for Medicaid services are generally paid at prospectively determined
rates per discharge, per occasion of service, or per covered member.
• Other: Payment agreements with certain commercial insurance carriers, health maintenance
organizations, and preferred provider organizations provide for payment using prospectively
determined rates per discharge, discounts from established charges, and prospectively
determined daily rates.
Laws and regulations concerning government programs, including Medicare and Medicaid, are complex
and subject to varying interpretation. As a result of investigations by governmental agencies, various
health care organizations have received requests for information and notices regarding alleged
noncompliance with those laws and regulations which, in some instances, have resulted in organizations
entering into significant settlement agreements. Compliance with such laws and regulations may also be
subject to future government review and interpretation, as well as significant regulatory action, including
fines, penalties, and potential exclusion from the related programs. There can be no assurance that
regulatory authorities will not challenge the Clinic’s compliance with these laws and regulations, and it is
not possible to determine the impact (if any) such claims or penalties would have upon the Clinic. In
addition, the contracts that the Clinic has with commercial payors also provide for retroactive audit and
review of claims.
Generally, patients who are covered by third-party payors are responsible for related deductibles and
coinsurance, which vary in amount. The Clinic also provides services to uninsured patients, and offers
those uninsured patients a discount, either by policy or law, from standard charges. The Clinic estimates
the transaction price for patients with deductibles and coinsurance and from those who are uninsured,
based on historical experience and current market conditions. The initial estimate of the transaction price
is determined by reducing the standard charge by any contractual adjustments, discounts, and implicit
price concessions. Subsequent changes to the estimate of the transaction price are generally recorded as
adjustments to medical service revenue in the period of the change. For the years ended December 31,
2022 and 2021, revenue recognized due to changes in its estimates of transaction price concessions for
performance obligations satisfied in prior years was $14 and $6, respectively. Subsequent changes that
are determined to be the result of an adverse change in the patient’s ability to pay are recorded as bad
debt expense. Bad debt expense for the years ended December 31, 2022 and 2021, was not significant.
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Mayo Clinic

Settlements with third-party payors for retroactive adjustments due to audits, reviews, or investigations
are considered variable consideration and are included in the determination of the estimated transaction
price for providing patient care. These settlements are estimated based on the terms of the payment
agreement with the payor, correspondence from the payor, and the Clinic’s historical settlement activity,
including an assessment to ensure it is probable a significant reversal in the amount of cumulative
revenue recognized will not occur when the uncertainty associated with the retroactive adjustment is
subsequently resolved. Estimated settlements are adjusted in future periods as adjustments become
known (that is, new information becomes available) or as years are settled or are no longer subject to
such audits, reviews, and investigations. Adjustments arising from a change in the transaction price for
the years ended December 31, 2022 and 2021 were not significant. Receivables from third-party payors
for final settlements was $60 and $10 for December 31, 2022 and December 31, 2021 respectively.
Patients who meet the Clinic’s criteria for charity care are provided care without charge or at amounts less
than established rates. Such amounts which are determined to qualify as charity care are not reported as
revenue.
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Mayo Clinic
The composition of medical service revenue based on the regions of the country in which the Clinic
operates, its lines of business, and timing of revenue recognition for the years ended December 31, 2022
and 2021, are as follows:
Year Ended December 31, 2022

Midwest Southeast Southwest Total
Hospital $ 5,210 $ 1,089 $ 1,294 $ 7,593
Clinic 3,404 844 961 5,209
Senior Care and Nursing Home 15 — — 15
Other 62 1 — 63
Total patient care service revenue 8,691 1,934 2,255 12,880
External lab 901 — — 901

Total medical service revenue $ 9,592 $ 1,934 $ 2,255 $ 13,781
Timing of revenue and recognition:

At time services are rendered $ 4,367 $ 845 $ 961 $ 6,173
Services transferred over time 5,225 1,089 1,294 7,608
Total $ 9,592 $ 1,934 $ 2,255 $ 13,781
Year Ended December 31, 2021

Midwest Southeast Southwest Total
Hospital $ 5,108 $ 987 $ 1,156 $ 7,251
Clinic 3,353 802 912 5,067
Senior Care and Nursing Home 15 — — 15
Other 58 1 — 59
Total patient care service revenue 8,534 1,790 2,068 12,392
External lab 918 — — 918

Total medical service revenue $ 9,452 $ 1,790 $ 2,068 $ 13,310
Timing of revenue and recognition:

At time services are rendered $ 4,329 803 912 $ 6,044
Services transferred over time 5,123 987 1,156 7,266
Total $ 9,452 $ 1,790 $ 2,068 $ 13,310
Hospital revenue includes a variety of services mainly covering inpatient procedures requiring overnight
stays or outpatient operations that require anesthesia or use of complex diagnostic and surgical
equipment, as well as emergency care for traumas and other critical conditions. Clinic revenue includes
services mainly focused on the care of outpatients covering primary and specialty health care needs. The
Clinic's practice is to record certain radiology, pathology, and other hospital related services in the
Midwest region as clinic revenue in the amount of $1,024 and $973 for the years ended December 31,
2022 and 2021, respectively. Examples of revenue at the time services are rendered include clinical
services, lab and transport, and services transferred over time include hospital and senior care revenue.
15
Mayo Clinic

The composition of medical service revenue by payor for the years ended December 31 is as follows:
2022 2021
Medicare $ 3,634 $ 3,377
Medicaid 565 475
Contract 7,916 7,705
Other, including self-pay 1,666 1,753
Total $ 13,781 $ 13,310
The Clinic’s practice is to assign a patient to the primary payor and not reflect other uninsured balances
(for example, coinsurance and deductibles) as self-pay. Therefore, the payors listed above contain patient
responsibility components, such as coinsurance and deductibles.
Financing component:
The Clinic has elected the practical expedient allowed under FASB ASU 2014-09, Revenue from
Contracts with Customers (Topic 606-10-32-18) and does not adjust the promised amount of
consideration from patients and third-party payors for the effects of a significant financing component due
to the Clinic’s expectation that the period between the time the service is provided to a patient and the
time that the patient or a third-party payor pays for that service will be one year or less. However, the
Clinic does, in certain instances, enter into payment agreements with patients that allow payments in
excess of one year. For those cases, the financing component is not deemed to be significant to the
contract.
Note 4. Fair Value Measurements

The Clinic holds certain financial instruments that are required to be measured at fair value on a recurring
basis. The valuation techniques used to measure fair value under the Fair Value Measurement (Topic
820) of the FASB ASC are based upon observable and unobservable inputs. The standard establishes a
three-level valuation hierarchy for disclosure of fair value measurements. The valuation hierarchy is
based upon the transparency of inputs to the valuation of an asset or liability as of the measurement date.
The three levels are defined as follows:
Level 1: Inputs to the valuation methodology are quoted prices (unadjusted) for identical assets or
liabilities in active markets.
Level 2: Inputs to the valuation methodology include quoted prices for similar assets or liabilities in active
markets, and inputs that are observable for the asset or liability, either directly or indirectly, for
substantially the same term of the financial instrument.
Level 3: Inputs to the valuation methodology are unobservable and significant to the fair value
measurement.
A financial instruments categorization within the valuation hierarchy is based upon the lowest level of
input that is significant to the fair value measurement. The Clinic’s policy is to recognize transfers in and
transfers out as of the actual date of the event or change in circumstances that caused the transfer. There
were no significant transfers or activity within Levels for the years ended December 31, 2022 and 2021.
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Mayo Clinic
Note 4. Fair Value Measurements (Continued)
The following tables present the financial instruments carried at fair value as of December 31, 2022 and
2021, by caption on the consolidated statements of financial position categorized by the valuation
hierarchy and NAV:
December 31, 2022

Total
Level 1 Level 2 Level 3 NAV Fair Value
Assets:
Securities lending collateral $ 3 $ — $ — $ — $ 3
Investments:
Cash and cash equivalents 1,258 72 — — 1,330
Fixed-income securities:
U.S. government — 1,956 — — 1,956
U.S. government agencies — 711 — — 711
U.S. corporate — 836 — — 836
Foreign — 58 — — 58
Common and preferred stocks:
U.S. 942 — — — 942
Foreign 646 — 20 — 666
Funds:
Fixed income 327 — — — 327
Equities 1,049 662 — — 1,711
Less securities under lending
agreement (68) — — — (68)
Investments at NAV — — — 8,719 8,719
Total investments 4,154 4,295 20 8,719 17,188
Investments under securities

lending agreement 68 — — — 68
Other long-term assets:

Trust receivables 65 27 112 — 204
Technology-based ventures — — 176 — 176
Total other long-term assets 65 27 288 — 380

Total assets at fair value $ 4,290 $ 4,322 $ 308 $ 8,719 $ 17,639
Liabilities:
Securities lending payable $ 3 $ — $ — $ — 3
Total liabilities at fair value $ 3 $ — $ — $ — $ 3
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Mayo Clinic
December 31, 2021

Total
Level 1 Level 2 Level 3 NAV Fair Value
Assets:
Securities lending collateral $ 6 $ — $ — $ — $ 6
Investments:
Cash and cash equivalents 2,593 238 — — 2,831
Fixed-income securities:
U.S. government — 566 — — 566
U.S. corporate — 832 — — 832
Foreign — 74 — — 74
U.S. 1,077 — — — 1,077
Foreign 658 — 24 — 682
Funds:
Equities 1,021 702 — — 1,723
Less securities under lending
agreement (95) — — — (95)
Total investments 5,702 2,963 24 9,237 17,926
Investments under securities

lending agreement 95 — — — 95
Other long-term assets:

Trust receivables 82 32 93 — 207
Technology-based ventures — — 138 — 138
Total other long-term assets 82 32 231 — 345
Total assets at fair value $ 5,885 $ 2,995 $ 255 $ 9,237 $ 18,372
Liabilities:
Securities lending payable $ 6 $ — $ — $ — 6
Total liabilities at fair value $ 6 $ — $ — $ — $ 6
The following is a description of the Clinic’s valuation methodologies for assets and liabilities measured at
fair value. Fair value for Level 1 is based upon quoted market prices. Fair value for Level 2 is based on
quoted prices for similar instruments in active markets, quoted prices for identical or similar instruments in
markets that are not active, and model-based valuation techniques for which all significant assumptions
are observable in the market or can be corroborated by observable market data for substantially the full
term of the assets and liabilities. Inputs are obtained from various sources, including market participants,
dealers, and brokers. Level 3 primarily consists of trusts recorded at fair value based on the underlying
value of the assets in the trust or discounted cash flow of the expected payment streams.
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Mayo Clinic
The trusts reported as Level 3 are primarily perpetual trusts managed by third parties invested in stocks,
mutual funds, and fixed-income securities that are traded in active markets with observable inputs and,
since the Clinic will never receive the trust assets, these perpetual trusts are reported as Level 3. In
addition, technology-based ventures, composed primarily of shares in start-up companies, are recorded
at fair value based on inputs relying on factors such as the financial performance of the company, sales
performance, financial projections, sales projections, management representation, industry
developments, market analysis, and any other pertinent factors that would affect the fair value or based
on the quoted price of an otherwise identical unrestricted security of the same issuer, adjusted for the
effect of the restriction.
The methods described above and those recorded at NAV may produce a fair value calculation that may
not be indicative of net realizable value or reflective of future fair values. Furthermore, while the Clinic
believes its valuation methods are appropriate and consistent with other market participants, the use of
different methodologies or assumptions to determine the fair value of certain financial instruments could
result in a different estimate of fair value at the reporting date.
The following information pertains to those alternative investments recorded at NAV in accordance with
Fair Value Measurement (Topic 820) of the FASB ASC.
At December 31, 2022, alternative investments recorded at NAV consisted of the following:
Redemption Redemption
Fair Unfunded Frequency (If Notice
Value Commitment Currently Eligible) Period
Absolute return/hedge funds (a) $ 3,705 $ 194 Monthly to annually 30–90 days
Private partnerships (b) 5,014 1,744
Total alternative investments $ 8,719 $ 1,938
Total alternative investments $ 9,237 $ 1,786
(a) This category includes investments in absolute return/hedge funds, which are actively managed
commingled investment vehicles that derive the majority of their returns from factors other than the
directional flow of the markets in which they invest. Representative strategies include high-yield
credit, distressed debt, merger arbitrage, relative value, and long-short equity strategies. The fair
values of the investments in this category have been estimated using the NAV per share of the
investments. Investments in this category generally carry “lockup” restrictions that do not allow
investors to seek redemption in the first year after acquisition. Following the initial lockup period,
liquidity is generally available monthly, quarterly, or annually following a redemption request. Over
90 percent of the investments in this category have at least annual liquidity.
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Mayo Clinic

(b) This category includes limited partnership interests in closed-end funds that focus on venture capital,
private equity, real estate, and resource-related strategies. The fair values of the investments in this
category have been estimated using the NAV of the Clinic’s ownership interest in partners’ capital.
Distributions from each fund will be received as the underlying investments of the funds are
liquidated. It is estimated that the underlying assets of most funds will generally be liquidated over a
seven- to ten-year period.
From time to time, the Clinic invests directly in certain derivative contracts that do not qualify for hedge
accounting and are recorded at fair value in investments. Changes in fair value are reported as a
component of net unrealized gains or losses in the investment returns. These contracts are used in the
Clinic’s investment management program to minimize certain investment risks. During the years ended
December 31, 2022 and 2021, the realized and unrealized loss from derivative contracts was not
significant.
The Clinic uses various external investment managers to diversify the investments. The largest allocation
to any investment strategy manager as of December 31, 2022 and 2021 was $801 (6.3 percent) and $831
(6.1 percent), respectively.
The Clinic is required to maintain funds held by trustees under bond indentures and other arrangements.
The trustee-held investments, which primarily consist of mutual funds, were $976 and $1,044,
respectively, at December 31, 2022 and 2021, which includes segregated investments for deferred
compensation plans of $929 and $1,041 at December 31, 2022 and 2021, respectively.
At December 31, 2022 and 2021, cash and mutual funds included segregated investments owned by
Mayo Foundation for Medical Education and Research, a wholly owned subsidiary of the Clinic, for gift
annuity reserves of $101 and $131, respectively.
The Clinic had internally designated investment balances of $2,978 and $3,392 at December 31, 2022
and 2021, respectively, for research, education, and capital replacement and expansion.
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Mayo Clinic
Note 5. Investments in Unconsolidated Entities
The Clinic holds certain investments in unconsolidated entities accounted for in accordance with FASB
Subtopic 323, Investments - Equity Method and Joint Ventures. The investments are presented as other
long-term assets in the consolidated statements of financial position. The Clinic's interest in the
investment income is reflected in the accompanying consolidated statements of operations.
The following table presents investments in unconsolidated entities as of December 31, 2022 and 2021:
Ownership Carrying Value Carrying Value

Percentage as of as of as of
December 31, 2022 December 31, 2022 December 31, 2021
Sheikh Shakhbout Medical City 25% $ 155 $ 89
Medically Home 29% $ 49 $ 57
Other investees various $ 10 $ 14
The Clinic entered into a joint venture agreement with Abu Dhabi Health Services Company PJSC to
operate Sheikh Shakhbout Medical City (SSMC), a 741-bed hospital in the United Arab Emirates. In
addition to the joint venture agreement, the Clinic has entered into a hospital expertise agreement, brand
license agreement, and research contribution agreement with SSMC. The joint venture has an initial
commitment period of twenty years and may be extended by ten years. The Clinic had a $150 conditional
pledge from Sheikh Shakhbout Medical City at December 31, 2022 and 2021.
In July 2021, the Clinic entered into a joint venture agreement with Kaiser Permanente to invest in
Medically Home to allow more patients to receive acute care and recovery services in the comfort,
convenience, and safety of their homes.
The summarized financial position and results of operations for significant entities accounted for under the
equity method as of and for the years ended consisted of the following:
2022 2021
As of December 31
Total assets $ 920 $ 794
Total liabilities $ 222 $ 194
Partners equity/net assets $ 698 $ 600
Year Ended December 31

Total revenue $ 524 $ 440
Loss from current activities $ (64) $ (65)
Note 6. Securities Lending

The Clinic has an arrangement with its investment custodian to lend Clinic securities to approved brokers
in exchange for a fee. Among other provisions that limit the Clinic’s risk, the securities lending agreement
specifies that the custodian is responsible for lending securities and obtaining adequate collateral from
the borrower. Collateral is limited to cash, government securities, and irrevocable letters of credit.
Investments are loaned to various brokers and are returnable on demand. In exchange, the Clinic
receives collateral. The cash collateral is shown as both an asset and a liability on the consolidated
statements of financial position.
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Mayo Clinic
Note 6. Securities Lending (Continued)
At December 31, 2022 and 2021, the aggregate market value of securities on loan under securities
lending agreements totaled $68 and $95, respectively, and the total value of the collateral supporting the
securities was $70 and $98, respectively, which represents 103% of the value of the securities on loan at
December 31, 2022 and 2021. The cash portion of the collateral supporting the securities as of December
31, 2022 and 2021 was $3 and $6, respectively. The cash portion is presented in other current assets
and other current liabilities in the consolidated statements of financial position. Noncash collateral
provided to the Clinic is not recorded in the consolidated statements of financial position, as the collateral
may not be sold or repledged. The Clinic’s claim on such collateral is limited to the market value of loaned
securities. In the event of nonperformance by the other parties to the securities lending agreements, the
Clinic could be exposed to a loss.
Note 7. Property, Plant, and Equipment, Net

Property, plant, and equipment, net, at December 31 consisted of the following:
2022 2021
Land $ 580 $ 489

Buildings and improvements 7,322 6,935
Furniture and equipment 4,633 4,347
12,535 11,771
Accumulated depreciation and amortization (7,414) (6,899)
5,121 4,872
Construction in progress 766 538
Total property, plant, and equipment $ 5,887 $ 5,410
The above costs and accumulated depreciation include costs for capitalized software, including costs
capitalized in accordance with Intangibles—Goodwill and Other, Internal-Use Software (Topic 350) of the
FASB ASC. The total cost for capitalized software was $893 and $874 at December 31, 2022 and 2021,
respectively. The total accumulated amortization was $647 and $581 at December 31, 2022 and 2021,
respectively. Amortization expense for capitalized software was $74 and $80 for 2022 and 2021,
respectively.
Note 8. Income Taxes

Most of the income received by the Clinic and its subsidiaries is exempt from taxation under Section
501(a) of the Internal Revenue Code. Some of its subsidiaries are taxable entities, and some of the
income received by otherwise exempt entities is subject to taxation as unrelated business income. The
Clinic and its subsidiaries file income tax returns in the U.S., including federal and various state returns,
as well as certain foreign jurisdictions. The statutes of limitations for tax years 2018 through 2020 remain
open in major U.S. taxing jurisdictions in which the Clinic and subsidiaries are subject to taxation.
The Internal Revenue Service (IRS) performed an examination of the tax and information returns of the
Clinic and two subsidiaries and ultimately assessed $12 in taxes for years 2003-2012. The results of this
audit were ultimately litigated in the U.S. District Court. On August 6, 2019, the Court issued a summary
judgment in favor of the Clinic. The IRS appealed this decision and on May 13, 2021, the Eighth Circuit
Court of Appeals reversed the summary judgment and remanded the case to the U.S. District Court for
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Mayo Clinic
Note 8. Income Taxes (Continued)

trial. The cased was tried in 2022 and the U.S. District Court issued a judgment in favor of the Clinic on
December 9, 2022. No adjustment has been made to unrecognized tax benefits as a result of the ruling
due to the IRS having until February 2023 to appeal.
The Clinic has reduced the reserve for uncertain tax positions by $2, including interest and penalties,
during the year ended December 31, 2022. As of December 31, 2022 and 2021, the reserve totaled $11
and $13, respectively. It is not anticipated that a significant change in the reserve will occur over the next
12 months.
The Clinic’s practice is to recognize interest and/or penalties related to income tax matters in income tax
expense. The components of tax expense are as follows:
Year ended December 31

2022 2021
Current—federal $ 23 $ 21
Current—state 6 5
29 26
Deferred—U.S. domestic (6) (1)

Total $ 23 $ 25
Cash payments for income taxes were $33 and $63 for the years ended December 31, 2022 and 2021,
respectively.
The Clinic records deferred income taxes due to temporary differences between financial reporting and
tax reporting for certain assets and liabilities of its taxable activities. The following is a summary of the
components of deferred taxes as of December 31:
2022 2021
Deferred compensation $ 9 $ 13
Pension — 9
Postretirement benefits 2 6
Net operating loss 6 18
Other 6 8
Total deferred tax asset 23 54
Deferred tax liability (2) (4)

Valuation allowance (10) (14)
Net deferred tax asset $ 11 $ 36
The Clinic had federal net operating losses of $20 and $51 at December 31, 2022 and 2021, respectively.
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Mayo Clinic
Note 8. Income Taxes (Continued)
The Tax Cuts and Jobs Act (TCJA), enacted on December 22, 2017 repealed Net Operating Loss (NOL)
carrybacks while permitting indefinite carryforwards. The Coronavirus Aid, Relief and Economic Security
Act enacted on March 27, 2020 temporarily suspended TCJA repeal of NOL carrybacks allowing for NOLs
arising in tax years beginning after December 31, 2017 and before January 1, 2021 to be carried back to
the five taxable years preceding the taxable year of such loss. During 2022 the Clinic was able to utilize
$50 of the NOLs arising in tax years beginning after December 31, 2018 and before January 1, 2022. Of
the remaining NOLS, $9 will be carried back and the remaining $11 will be carried forward.
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Mayo Clinic
Note 9. Financing
Long-term debt at December 31 consisted of the following:
2022 2021
City of Rochester, Minnesota Revenue Bonds issued in various
series, subject to variable interest rates to a maximum rate of
15.00% (the average rate was 1.27% in 2022 and 0.08% in 2021),
principal due in varying amounts from 2028 through 2052 Variable $ 545 $ 545
City of Rochester, Minnesota Revenue Bonds originally issued at
variable interest rate, converted in 2017 to fixed interest rate of
2.20% based on a provision to increase the rate if the federal tax
rate is decreased, the rate has been adjusted to 2.67% effective
January 1, 2018 through 2027, principal due in varying amounts
from 2022 through 2032 Fixed 163 200
City of Rochester, Minnesota Revenue Bonds originally issued with
fixed interest rate of 4.74%, converted in 2020 to fixed interest rate
of 1.54% until 2030, principal due in varying amounts from 2033
through 2038 Fixed 130 130
City of Rochester, Minnesota Revenue Bonds issued in various
series with fixed rate of interest of 4.00%, principal due in varying
amounts from 2044 through 2048 Fixed 200 400
City of Rochester, Minnesota Health Care Facilities Revenue
Refunding Bonds, series 2016B, issued with fixed interest rate of
5.00%, an effective rate of 2.97% in 2022 and 2021 after
amortization of premium, principal due in varying amounts from
2029 through 2036 (unamortized premium of $46 in 2022 and $50
in 2021) Fixed 220 220
City of Rochester, Minnesota Health Care Facilities Revenue Bonds,
series 2022, issued in various series with fixed interest rates
ranging from 3.25% to 5.00%, an effective rate of 3.74% in 2022
after amortization of premium principal due in varying amounts
from 2039 through 2057 (unamortized net premium of $16 in 2022) Fixed 289 —
Industrial Development Authority of the City of Phoenix, Arizona
issued in various series, subject to variable interest rates to a
maximum rate of 10.00% (the average rate was 0.96% in 2022 and
0.02% in 2021), principal due in varying amounts from 2048
through 2052 Variable 180 180
City of Jacksonville, Florida Health Care Facilities Revenue
Refunding Bonds, series 2016, issued in various series, subject to
variable interest rates to a maximum rate of 10.00% (the average
rate was 1.32% in 2022 and 0.13% in 2021), principal due in
varying amounts from 2033 through 2047 Variable 125 125
Mayo Clinic Taxable Bonds issued with fixed interest rates ranging
from 3.20% to 4.13%, principal due in varying amounts from 2039
through 2061 Fixed 1,450 1,450
Fixed-rate notes and bonds, payable to financial companies, interest
rates at 1.80% to 4.71%, principal due in varying amounts from
2025 through 2062 Fixed 1,115 915
The Industrial Development Authority of the City of Phoenix, Arizona
Health Care Facilities Revenue Bonds, series 2022, issued in
various series with fixed interest rates ranging from 3.75% to
4.00%, an effective rate of 3.80% in 2022 after amortization of
premium, principal due in varying amounts from 2053 to 2057
(unamortized net premium of $3 in 2022) Fixed 298 —
Other notes payable 12 12
Unamortized discounts and premiums, net 66 46
Debt issuance cost (16) (13)
4,777 4,210
Long-term variable-rate debt classified as current (620) (620)
Current maturities included in other current liabilities (36) (38)
Long-term debt, net of current portion $ 4,121 $ 3,552
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Mayo Clinic
Note 9. Financing (Continued)
The Clinic’s outstanding revenue bond issues are limited obligations of various issuing authorities payable
solely by the Clinic pursuant to loan agreements between the borrowing entities and the issuing
authorities. Under various financing agreements, the Clinic must meet certain operating and financial
performance covenants.
At December 31, 2022, the $850 of variable-rate bonds consisted of variable-rate demand revenue
bonds. In conjunction with the issuance of the variable-rate demand revenue bonds, the Clinic has
entered into various bank standby purchase and credit agreements in the amount of $230 of which $140
will expire in January 2024 and $90 will expire in January 2025. Under the terms of these agreements, the
bank will make liquidity loans to the Clinic in the amount necessary to purchase a portion of the variable-
rate demand revenue bonds if not remarketed. The liquidity loans would be payable over a three- to five-
year period, with the first payment due after December 31, 2023. The Clinic has provided self-liquidity for
the remaining $620 of variable-rate demand revenue bonds, which have been classified as current in the
accompanying consolidated statements of financial position.
The $220 fixed-rate revenue bonds Series 2016B are not callable. The remaining fixed-rate interest
revenue bonds are callable from 2023 to 2058 at the option of the Clinic, at a redemption price of 100
percent of the principal amount or at a price based on U.S. Treasury rates at the time of redemption.
In April 2021, the Clinic issued bonds in the amount of $500 with a 3.20 percent fixed rate of interest. The
bonds are due in 2061 and will be used for general corporate purposes.
On April 12, 2022 the Clinic issued fixed rate bonds in the amount of $587 ($200 refunding and $387 new
debt issuance) at various coupon rates yielding 3.76 percent to maturity. The bonds are due in 2057 and
the new debt will be used for construction projects.
On May 5, 2022, the Clinic entered into a private placement debt agreement with an insurance company
for $200 at 3.26 percent maturing in 2058. The funds will be used for general corporate purposes.
The following are scheduled maturities of long-term debt for each of the next five years, assuming the
variable-rate demand revenue bonds are remarketed and the standby purchase agreements are
renewed. As described above, if such bonds are not remarketed, $620 may be due in 2023 and $230 may
be due in years from 2024 to 2025.
Years ending December 31:

2023 $ 36
2024 18
2025 105
2026 5
2027 105
Interest payments on long-term debt, net of amounts capitalized for 2022 and 2021, totaled $132 and
$118, respectively. The amount of interest capitalized, net of related interest income, was $8 and $3
during 2022 and 2021. Interest expense totaled $144 and $121 for 2022 and 2021, respectively.
At December 31, 2022 and 2021, the Clinic had unsecured lines of credit available with banks that totaled
$530, with varying renewable terms and interest up to 2.50 percent over various published rates. There
were no amounts drawn during the years ended December 31, 2022 and 2021.
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Mayo Clinic
Note 10. Leases

At December 31, 2022 and 2021, the Clinic had operating and finance leases for facilities and certain
equipment with lease terms ranging from 1 to 20 years, with some options to extend up to five years or
terminate within one year.
Total lease expense for the years ended December 31 consisted of the following:
2022 2021
Operating lease expense $ 34 $ 34
Finance lease expense:

Amortization of right-of-use assets $ 6 $ 10
Interest on lease liabilities 1 1
Total finance lease expense $ 7 $ 11
Short-term lease expense $ 28 $ 24
Consolidated supplemental cash flow information related to leases as of December 31 consisted of the
following:
2022 2021
Cash paid for amounts included in the measurement
of lease liabilities:
Operating cash flows for operating leases $ 60 $ 55
Operating cash flows for finance leases $ 1 $ 1
Financing cash flows for finance leases $ 7 $ 6
Right-of-use assets obtained in exchange for lease obligations:

Operating leases $ 18 $ 21
Finance leases $ 4 $ 4
Consolidated supplemental statement of financial position information related to leases as of the years
ended December 31 consisted of the following:
2022 2021
Operating leases:
Right-of-use assets $ 141 $ 151
Other current liabilities $ 23 $ 25

Other long-term liabilities 123 131
Total operating lease liabilities $ 146 $ 156
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Mayo Clinic
Note 10. Leases (Continued)

2022 2021
Finance leases:
Property, plant, and equipment, gross $ 57 $ 62
Accumulated depreciation 36 38
Property, plant, and equipment, net $ 21 $ 24
Other current liabilities $ 6 $ 6

Other long-term liabilities — 16
Total finance lease liabilities $ 6 $ 22
Weighted average remaining lease years:

Operating leases 9.22 9.85
Finance leases 4.14 4.70
Weighted average discount rate:

Operating leases 3.35 % 3.37 %
Finance leases 2.98 % 3.04 %
Maturities of lease liabilities for the next five years and thereafter consist of the following:
Operating Finance
2023 $ 27 $ 7
2024 24 5
2025 20 3
2026 18 2
2027 15 1
Thereafter 70 2
Minimum lease payments 174 20
Less amount representing interest 28 1

Net minimum lease payments $ 146 $ 19
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Note 11. Board-Designated Funds
Board-designated funds are subject to expenditure for the following purposes for the years ended
December 31:
2022 2021
Research $ 1,365 $ 1,545
Education 312 358
Buildings and equipment 3 4
Charity care 12 14
Clinical 162 190
Other 1,124 1,281
Total designation for specified purpose $ 2,978 $ 3,392
At December 31, board designated funds were classified as follows:
2022 2021
Quasi-endowments $ 2,830 $ 3,218
Professional liability reserve 119 141
Other $ 29 $ 33
Total $ 2,978 $ 3,392
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Mayo Clinic
Note 12. Net Assets with Donor Restrictions
The Clinic receives contributions in support of research, education, and clinical activities. Net assets with
donor restrictions were available for the following purposes at December 31:
2022 2021
Subject to expenditure for specified purposes:
Research $ 582 $ 497
Education 59 46
Charity care 30 30
Clinical 74 65
Other 30 53
Total expenditure for specified purposes 1,020 865
Subject to passage of time:

Pledges and trusts 642 649
Endowments:
Perpetual in nature:
Research 1,233 1,140
Education 304 270
Charity care 14 14
Clinical 222 215
Other 31 33
Pledges and trusts 270 274
Total perpetual in nature 2,074 1,946
Subject to endowment spending policy:

Research 745 1,028
Education 342 433
Charity care 48 59
Clinical 152 206
Other 40 50
Total subject to endowment spending policy 1,327 1,776
Total endowments 3,401 3,722
Total net assets with donor restrictions $ 5,063 $ 5,236
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Mayo Clinic
Note 12. Net Assets with Donor Restrictions (Continued)
Net assets were released from donor restrictions as expenditures were made, which satisfied the
following restricted purposes for the years ended December 31:
2022 2021
Research $ 180 $ 188
Education 25 22
Other 96 23
Total net assets released from donor restrictions $ 337 $ 430
Note 13. Endowment
The Clinic’s endowment consists of approximately 2,300 individual funds established for a variety of
purposes. The endowment includes both donor-restricted endowment funds and funds designated by the
Board of Trustees to function as endowments (quasi-endowments). Net assets associated with
endowment funds, including quasi endowments, are classified and reported based on the existence or
absence of donor-imposed restrictions. The Board of Trustees retains the right to re-designate quasi
endowments for other purposes.
The Board of Trustees of the Clinic has interpreted the Minnesota State Prudent Management of
Institutional Funds Act (SPMIFA) as requiring the preservation of the fair value of the original gift as of the
gift date of the donor-restricted endowment funds, absent explicit donor stipulations to the contrary. As a
result of this interpretation, the Clinic retains in perpetuity: (a) the original value of gifts donated to the
permanent endowment, (b) the original value of subsequent gifts to the perpetual endowment, and (c)
accumulations to the perpetual endowment made in accordance with the direction of the applicable donor
gift instrument at the time the accumulation is added to the fund.
In accordance with SPMIFA, the Clinic considers the following factors in making a determination to
appropriate or accumulate donor-restricted funds:
1. The duration and preservation of the fund

2. The purposes of the Clinic and the donor-restricted endowment fund
3. General economic conditions
4. The possible effects of inflation and deflation
5. The expected total return from income and the appreciation of investments
6. Other resources of the Clinic
7. The investment policies of the Clinic
The Clinic has adopted investment and spending policies for endowment assets that attempt to provide a
predictable stream of funding to programs supported by its endowment, while seeking to maintain
purchasing power of the endowment assets. Endowment assets include those assets of donor-restricted
funds that the Clinic must hold in perpetuity or for a donor-specified period(s), as well as quasi-
endowments. Under this policy, as approved by the Board of Trustees, the endowment assets are
invested in a manner that is intended to produce a real return, net of inflation and investment
management costs, of at least five percent over the long term. Actual returns in any given year may vary
from this amount.
To satisfy its long-term rate-of-return objectives, the Clinic relies on a total return strategy in which
investment returns are achieved through both capital appreciation (realized and unrealized) and current
yield (interest and dividends). The Clinic targets a diversified asset allocation that places a greater
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Mayo Clinic
Note 13. Endowment (Continued)
emphasis on equity-based and alternative investments to achieve its long-term objective within prudent
risk constraints.
The Clinic has a policy of appropriating for distribution each year five percent of its endowment fund’s
moving average fair value over the prior 36 months as of September 30 of the preceding year in which the
distribution is planned. In establishing this policy, the Clinic considered the long-term expected return on
its endowment. Accordingly, over the long term, the Clinic expects the current spending policy to allow its
endowment to grow at an average of the long-term rate of inflation. This is consistent with the Clinic’s
objective to maintain the purchasing power of the endowment assets held in perpetuity or for a specific
term, as well as to provide additional real growth through new gifts and investment return.
At December 31, 2022, the endowment net asset composition by type of fund consisted of the following:
Without Donor With Donor
Restrictions Restrictions Total
Donor-restricted funds $ — $ 3,401 $ 3,401

Quasi-endowments 2,830 — 2,830
Total funds $ 2,830 $ 3,401 $ 6,231
Changes in endowment net assets for the year ended December 31, 2022, consisted of the following:

Endowment net assets, beginning of year $ 3,218 $ 3,722 $ 6,940
Investment return:
Investment income 32 34 66
Net depreciation (realized and unrealized) (330) (356) (686)
Total investment return (298) (322) (620)
Contributions — 128 128
Appropriation of endowment assets for expenditure (146) (127) (273)
Other changes:
Transfers to create quasi-endowments 56 56
Endowment net assets, end of year $ 2,830 $ 3,401 $ 6,231
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Note 13. Endowment (Continued)
At December 31, 2021, the endowment net asset composition by type of fund consisted of the following:
Donor-restricted funds $ — $ 3,722 $ 3,722

Quasi-endowments 3,218 — 3,218
Total funds $ 3,218 $ 3,722 $ 6,940
Changes in endowment net assets for the year ended December 31, 2021, consisted of the following:

Endowment net assets, beginning of year $ 2,694 $ 3,037 $ 5,731
Investment return:
Investment income 40 42 82
Net appreciation (realized and unrealized) 581 640 1,221
Total investment return 621 682 1,303
Contributions — 108 108
Appropriation of endowment assets for expenditure (119) (105) (224)
Other changes:
Transfers to create quasi endowments 22 — 22
Endowment net assets, end of year $ 3,218 $ 3,722 $ 6,940
Note 14. Promises to Give
At December 31, outstanding pledges from various corporations, foundations, and individuals, included in
other receivables and other long-term assets, were as follows:
2022 2021
Pledges due:
In less than one year $ 319 $ 294
In one to five years 367 399
In more than five years 64 35
750 728
Allowance for uncollectible pledges and discounts (38) (34)
Total $ 712 $ 694
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Mayo Clinic
Note 14. Promises to Give (Continued)
Estimated cash flows from pledge receivables due after one year are discounted using a risk-adjusted
rate, ranging from 1 percent to 6 percent, that is commensurate with the pledges due dates and
established in the year the pledge is received.
The Clinic has received interests in various trusts, primarily split-interest, which are included in other long-
term assets. The trusts are recorded at fair value, based on the underlying value of the assets in the trust
or discounted cash flow using a risk-adjusted discount rate of 3.12 percent and 2.91 percent at December
31, 2022 and 2021, respectively. During the years ended December 31, 2022 and 2021, there were no
contributions recorded related to the split-interest trusts. The balance of the expected payment streams
was $204 and $207 at December 31, 2022 and 2021, respectively.
Note 15. Functional Expenses

The consolidated financial statements present certain expenses that are attributed to more than one
program or supporting function. Therefore, expenses require allocation on a reasonable basis that is
consistently applied. Benefits and payroll taxes are allocated based on factors of either salary expense or
hours worked. Overhead costs that include professional services, office expenses, information
technology, interest, insurance, and other similar expenses are allocated based on a variety of factors,
including revenues, hours worked, and salary expense. Costs related to space, including occupancy,
depreciation and amortization, and property taxes, are allocated on a square footage basis.
The expenses reported in the consolidated statements of activities for the years ended December 31,
2022 and 2021 supported the following programs and functions:
2022
Lab and Graduate and

technology other General and Development Other Total
Patient care ventures Research education administrative expenses activities expenses
Salaries and benefits $ 7,664 $ 197 $ 690 $ 343 $ 210 $ 19 $ 47 $ 9,170
Supplies and services 3,789 1,073 280 72 62 11 90 5,377

Depreciation and
amortization 512 8 69 10 22 1 2 624
Facilities 268 5 18 12 44 1 2 350

Finance and
investment 152 9 18 2 2 — (9) 174
Total $ 12,385 $ 1,292 $ 1,075 $ 439 $ 340 $ 32 $ 132 $ 15,695
2021
Lab and Graduate and

technology other General and Development Other Total
Patient care ventures Research education administrative expenses activities expenses
Salaries and benefits $ 7,330 $ 187 $ 653 $ 331 $ 103 $ 16 $ 41 $ 8,661
Supplies and services 3,299 1,048 258 61 24 8 69 4,767

Depreciation and
amortization 515 8 66 11 15 1 3 619
Facilities 264 4 18 12 26 1 1 326

Finance and
investment 150 3 18 1 1 — (29) 144
Total $ 11,558 $ 1,250 $ 1,013 $ 416 $ 169 $ 26 $ 85 $ 14,517
34
Mayo Clinic
Note 16. Employee Benefit Programs

The Clinic serves as plan sponsor for several defined benefit pension funds and other postretirement
benefits.
Included in other changes in unrestricted net assets at December 31, 2022 and 2021, are the following
amounts, respectively, that have not yet been recognized in net periodic cost: unrecognized actuarial
losses of $137 and $3,053 and unrecognized prior service benefit of $63 and $109. Actuarial losses are
amortized as a component of net periodic pension cost, only if the losses exceed ten percent of the
greater of the projected benefit obligation or the fair value of plan assets. Unrecognized prior service
benefits are amortized on a straight-line basis over the estimated life of plan participants.
Changes in plan assets and benefit obligations recognized in unrestricted net assets during 2022 and
2021 included the following:
2022 2021
Current-year actuarial gain $ 2,659 $ 1,440

Amortization of actuarial loss 246 338
Amortization of prior service credit (46) (50)
Pension and other postretirement benefit adjustments $ 2,859 $ 1,728
Pension plans:
Obligations and funded status: The following is a summary of the changes in the benefit obligation and
plan assets, the resulting funded status of the qualified and nonqualified pension plans, and accumulated
benefit obligation as of and for the years ended December 31:
2022 2021
Change in projected benefit obligation:
Benefit obligation, beginning of year $ 12,194 $ 12,360
Service cost 690 691
Interest cost 370 350
Actuarial (gain) loss (4,381) (302)
Benefits paid (1,058) (905)
Settlements (6) —
Estimated benefit obligation at end of year $ 7,809 $ 12,194
Change in plan assets:

Fair value of plan assets, beginning of year $ 11,903 $ 10,642
Actual return on plan assets (1,188) 1,793
Employer contributions 314 373
Benefits paid (1,058) (905)
Settlements (6) —
Fair value of plan assets at end of year $ 9,965 $ 11,903
35
Mayo Clinic
Note 16. Employee Benefit Programs (Continued)
2022 2021
Funded status of the plans $ 2,156 $ (291)
Accumulated benefit obligation $ (7,361) $ (11,441)
Amounts recognized in the consolidated statements of financial position consist of the following at
December 31:
2022 2021
Noncurrent assets $ 2,164 $ —

Noncurrent liabilities $ (8) $ (291)
Net amount recognized $ 2,156 $ (291)
Components of net periodic benefit cost are as follows for the years ended December 31:
2022 2021
Service cost $ 690 $ 691

Interest cost 370 350
Expected return on plan assets (781) (732)
Amortization of unrecognized:
Prior service benefit (50) (50)
Net actuarial loss 226 306
Settlement 2 —
Net periodic benefit cost $ 457 $ 565
Plan assets: The largest of the pension funds is the Mayo Clinic Master Retirement Trust Plan, which
holds $9,864 of the $9,965 in combined plan assets at December 31, 2022, and $11,765 of the $11,903 in
combined plan assets at December 31, 2021. The investment policies described below apply to the Mayo
Clinic Master Retirement Trust Plan (the Plan).
The Plan employs a global, multi-asset approach in managing its retirement plan assets. This approach is
designed to maximize risk-adjusted returns over a long-term investment horizon, consistent with the
nature of the pension liabilities being funded. The plan asset portfolio’s target allocation for total return
investment strategies, which include public equities, private equities, absolute return, and real assets, is
82.5 percent. The portfolio’s target fixed-income exposure is 17.5 percent. The fixed-income exposure
may include the use of long-term interest rate swap contracts structured to increase the portfolio’s interest
rate sensitivity and thereby provide a hedge of the plan liabilities resulting from falling long-term interest
rates. Investments in private equities, real assets, and absolute return strategies are held to improve
diversification and thereby enhance long-term, risk-adjusted returns. However, recognizing that these
investments are not as liquid as publicly traded stocks and bonds, portfolio investment policies limit
overall exposure to these assets. The portfolio’s allocation to private equities and real assets is limited to
a maximum of 30 percent (with a target allocation of 22.5 percent), and exposure to absolute return
strategies is limited to a maximum of 35 percent (with a target of 27.5 percent). The Clinic reviews
performance, asset allocation, and risk management reports for plan asset portfolios on a monthly basis.
36
Mayo Clinic

The fair values of the Plan’s assets at December 31, 2022, by asset category, are as follows:
Quoted Prices
in Active Significant Significant
Markets for Observable Unobservable
Identical Assets Inputs Inputs
Assets (Level 1) (Level 2) (Level 3) NAV Total
Cash and cash equivalents $ 162 $ 4 $ — $ — $ 166

Fixed income securities:
U.S. corporate — 316 — — 316
Foreign — 36 — — 36
U.S. 777 — — — 777
Foreign 479 — — — 479
Funds:
Equities 34 637 — — 671
Foreign 47 1 — — 48
Total investments $ 1,560 $ 1,244 $ — $ 7,060 $ 9,864
The fair values of the Plan’s assets at December 31, 2021, by asset category, are as follows:
Quoted Prices
in Active Significant Significant
Markets for Observable Unobservable
Identical Assets Inputs Inputs
Assets (Level 1) (Level 2) (Level 3) NAV Total
Cash and cash equivalents $ 518 $ 61 $ — $ — $ 579

Fixed income securities:
U.S. corporate — 400 — — 400
Foreign — 52 — — 52
U.S. 1,077 — — — 1,077
Foreign 645 — — — 645
Funds:
Equities 65 718 — — 783
Foreign 69 — — — 69
Total investments $ 2,488 $ 1,521 $ — $ 7,756 $ 11,765
37
Mayo Clinic

The following is a description of the Plan’s valuation methodologies for assets and liabilities measured at
fair value. Fair value for Level 1 is based upon quoted market prices. Fair value for Level 2 is based on
quoted prices for similar instruments in active markets, quoted prices for identical or similar instruments in
markets that are not active, and model-based valuation techniques for which all significant assumptions
are observable in the market or can be corroborated by observable market data for substantially the full
term of the assets or liabilities. Inputs are obtained from various sources, including market participants,
dealers, and brokers.
A financial instrument’s categorization within the valuation hierarchy is based upon the lowest level of
input that is significant to the fair value measurement. The Clinic’s policy is to recognize transfers in and
transfers out as of the actual date of the event or change in circumstances that caused the transfer. There
were no significant transfers in 2022 or 2021.
The methods described above and those recorded at NAV may produce a fair value calculation that may
not be indicative of net realizable value or reflective of future fair values. Furthermore, while the Plan
believes its valuation methods are appropriate and consistent with other market participants, the use of
different methodologies or assumptions to determine the fair value of certain financial instruments could
result in a different estimate of fair value at the reporting date.
The following information pertains to those alternative investments recorded at NAV in accordance with
Fair Value Measurement (Topic 820) of the FASB ASC.
$ 7,060 $ 1,485
$ 7,756 $ 1,396
(a) This category includes investments in absolute return/hedge funds, which are actively managed
commingled investment vehicles that derive the majority of their returns from factors other than the
directional flow of the markets in which they invest. Representative strategies include high-yield
credit, distressed debt, merger arbitrage, relative value, and long-short equity strategies. The fair
values of the investments in this category have been estimated using the NAV per share of the
investments. Investments in this category generally carry “lockup” restrictions that do not allow
investors to seek redemption in the first year after acquisition. Following the initial lockup period,
38
Mayo Clinic

liquidity is generally available monthly, quarterly, or annually following a redemption request. Over
90 percent of the investments in this category have at least annual liquidity.
(b) This category includes limited partnership interests in closed-end funds that focus on venture capital,
private equity, real estate, and resource-related strategies. The fair values of the investments in this
category have been estimated using the NAV of the Plan’s ownership interest in partners’ capital.
These investments cannot be redeemed with the funds. Distributions from each fund will be received
as the underlying investments of the funds are liquidated. It is estimated that the underlying assets of
most funds will generally be liquidated over a seven- to ten-year period.
No plan assets are expected to be returned to the employer during 2023.
Other postretirement benefits:
Obligations and funded status: A summary of the changes in the benefit obligation and plan assets and
the resulting funded status of the other postretirement plans is as follows as of and for the years ended
December 31:
2022 2021
Change in projected benefit obligation:
Benefit obligation at beginning of year $ 1,138 $ 1,228
Service cost 7 9
Interest cost 34 32
Plan participants contributions 41 35
Medicare subsidy 2 3
Actuarial (gain) (255) (82)
Benefits paid (100) (87)
Estimated benefit obligation at end of year $ 867 $ 1,138
Change in plan assets:

Fair value of plan assets at beginning of year $ — $ —
Employer contributions 59 52
Plan participants contributions 41 35
Benefits paid (100) (87)
Fair value of plan assets at end of year $ — $ —
Funded status of the plan $ (867) $ (1,138)
Amounts recognized in the consolidated statements of financial position for postretirement benefits
consist of the following at December 31:
2022 2021
Current liabilities $ (56) $ (51)

Noncurrent liabilities (811) (1,087)
Net amount recognized $ (867) $ (1,138)
39
Mayo Clinic

Components of net periodic benefit cost for other postretirement benefits are as follows for the years
ended December 31:
2022 2021
Service cost $ 7 $ 9
Interest cost 34 32
Amortization of:
Unrecognized prior service benefit 4 —
Unrecognized net actuarial loss 20 32
Net periodic benefit cost for other postretirement benefits $ 65 $ 73
The Clinic has concluded that the prescription drug benefits under its defined benefit postretirement plan
are actuarially equivalent to Medicare Part D under the Medicare Modernization Act (the Act) and that the
Clinic will receive the subsidy available under the Act.
The following reflects the expected future Medicare Part D subsidy receipts:

2023 $ 3
2024 3
2025 3
2026 3
2027 3
2028–2032 16
Plan trend rates are the annual rates of increase expected for the benefits payable from the plan; these
rates include health care cost trends plus the leveraging effect of plan design. The assumed plan trend
rate is 5.50 percent.
Pension and postretirement benefits:
Assumptions: Weighted average assumptions used to determine pension and postretirement benefit
obligations at the measurement date are as follows:
Pension Benefits Postretirement Benefits

2022 2021 2022 2021
Discount rate 5.77% 3.12% 5.68% 3.04%

Rate of compensation increase 3.67% 3.72% N/A N/A
40
Mayo Clinic

Weighted-average assumptions used to determine net periodic pension and postretirement benefit cost
are as follows:
Pension Benefits Postretirement Benefits
2022 2021 2022 2021
Discount rate 3.12% 2.91% 3.04% 2.70%

Expected long-term return on plan assets 7.50% 7.50% N/A N/A
Rate of compensation increase 3.72% 3.70% N/A N/A
The change in the discount rate from 3.12% to 5.77% for the pension plans and from 3.04% to 5.68% for
the other postretirement plans had the net effect of decreasing the projected benefit obligations by $5,222
for the year ended December 31, 2022.
The Clinic utilizes a building block approach in determining the expected long-term rate of return for its
plan assets. First, historical data on individual asset class returns are studied. Next, the historical
correlation among and between asset class returns is studied under both normal conditions and in times
of market turbulence. Then, various mixes of asset classes are considered under multiple long-term
investment scenarios. Finally, after considering liquidity concerns related to the use of certain alternative
asset classes, the plan sponsor selects the portfolio blend that it believes will produce the highest
expected long-term return on a risk-adjusted basis.
Cash flows:
Contributions: The Clinic expects to contribute $283 to its pension plans in 2023.
Estimated future benefit payments: The following benefit payments, which reflect expected future
service, as appropriate, are expected to be paid:
Pension Postretirement
Benefits Benefits
2023 $ 499 $ 58
2024 508 59
2025 526 60
2026 544 62
2027 566 63
2028–2032 3,019 325
In addition to the defined benefit plans, the Clinic sponsors various defined contribution benefit plans.
Expense recognized by the Clinic for those plans was $131 and $124 for 2022 and 2021, respectively.
Note 17. General and Professional Liability Insurance

The Clinic insures substantially all general and professional liability risks through a combination of a
wholly owned captive insurance company and self-insurance. The insurance program combines various
levels of self-insured retention with excess commercial insurance coverage. Actuarial consultants have
been retained to assist in the estimation of outstanding general and professional liability losses.
41
Mayo Clinic
Note 17. General and Professional Liability Insurance (Continued)
The Clinic’s general and professional liability as reported in the accompanying consolidated statements of
financial position was $159 and $133 at December 31, 2022 and 2021, respectively. Provisions for the
general and professional liability risks are based on an actuarial estimate of losses using the Clinic’s
actual loss data, adjusted for industry trends and current conditions, and considering an evaluation of
claims by the Clinic’s legal counsel. The provision includes estimates of ultimate costs for both reported
claims and claims incurred but not reported.
Activity in the liability is summarized as follows for the years ended December 31:
2022 2021
Balance, beginning of year $ 133 $ 118
Incurred related to captive insurance company liability:

Current year 30 29
Prior years 12 —
Total incurred 42 29
Paid related to captive insurance company liability:

Current year (1) (2)
Prior years (24) (10)
Total paid (25) (12)
Net change in self-insurance liability 9 (2)

Balance, end of year $ 159 $ 133
Note 18. Other Receivables, Other Current and Long-Term Assets, and Other Current and Long-
Term Liabilities
At December 31, other receivables consisted of the following:
2022 2021
Pledges receivable $ 319 $ 294

Grants receivable 145 134
Pharmacy receivable 58 26
Rebates receivable 34 38
Interest receivable 28 16
Royalty receivable 25 15
Other tax receivable 7 33
Other 143 92
Total other receivables $ 759 $ 648
42
Mayo Clinic
Term Liabilities (Continued)
At December 31, other current assets consisted of the following:
2022 2021
Inventories $ 218 $ 203

Prepaid expenses 166 108
Other 2 6
Total other current assets $ 386 $ 317
At December 31, other long-term assets consisted of the following:
2022 2021
Pension asset $ 2,164 $ —

Pledges receivable 393 400
Investments in unconsolidated entities 214 160
Trust receivables 204 207
Oil and gas interests 199 191
Technology-based ventures 176 138
Operating lease right-of-use asset 141 151
Notes receivable 29 16
Prepaid maintenance 23 14
Long-term portion of deferred tax asset 11 36
Other 77 94
Total other long-term assets $ 3,631 $ 1,407
43
Mayo Clinic
Term Liabilities (Continued)
At December 31, other current liabilities consisted of the following:
2022 2021
Other taxes $ 87 $ 83
Current portion of long-term disability 49 42
Current portion of professional and general liability 43 38
Current maturities of long-term debt 36 38
Short-term disability 30 36
Real estate tax accrual 28 28
Refunds/recoupments 24 21
Operating lease liability 23 25
Accrued interest 20 15
Oil and gas liability 15 81
Medicare settlements liability 13 34
Current portion of workers' compensation liability 11 11
Finance lease liability 6 6
Other 85 51
Total other current liabilities $ 470 $ 509
At December 31, other long-term liabilities consisted of the following:
2022 2021
Deferred compensation $ 929 $ 1,041

Long-term disability 224 226
Deferred gain 135 74
Operating lease liability 123 131
Professional and general liability 116 95
Electronic medical record 96 101
Retirement community obligations 85 86
Gift annuities 65 67
Financing obligations 60 53
Trust obligations 57 55
Asset retirement obligation 55 55
Workers’ compensation liability 32 32
Contract deposit 22 22
Finance lease liability — 16
Other 84 79
Total other long-term liabilities $ 2,083 $ 2,133
44
Mayo Clinic
Note 19. Other Revenue

For the years ended December 31, other revenue consisted of the following:
2022 2021
Retail pharmacy sales $ 475 $ 436

Oil and gas producing activities 156 101
Royalties 130 166
Retail stores 71 67
Graduate medical and other education revenue 46 35
Technology commercialization, health information, and medical
products 43 52
Cafeteria revenue 32 29
Provider relief funds and other support — 1
Other 274 244
Total other revenue $ 1,227 $ 1,131
Note 20. Commitments and Contingencies

The Clinic has various construction projects in progress related to patient care, research, and educational
facilities. The estimated costs committed to complete the various projects at December 31, 2022 is
$1,677, all of which is expected to be expended over the next three to five years.
While the Clinic is self-insured for a substantial portion of its general and workers’ compensation liabilities,
the Clinic maintains commercial insurance coverage against catastrophic loss. Additionally, the Clinic
maintains a self-insurance program for its long-term disability coverage. The provision for estimated self-
insured claims includes estimates of the ultimate costs for both reported claims and claims incurred but
not reported.
The Clinic is a defendant in various lawsuits arising in the ordinary course of business and records an
estimated liability for probable claims. Although the outcome of these lawsuits cannot be predicted with
certainty, management believes the ultimate disposition of such matters will not have a material effect on
the Clinic’s consolidated financial position or consolidated statement of activities.
Note 21. COVID-19
In March 2020, the World Health Organization declared the novel coronavirus disease (COVID-19) a
pandemic. The Center for Disease Control confirmed its spread to the United States and declared a
national public health emergency. The Clinic was well-prepared and continues to treat patients with
COVID-19 across the organization, especially those with serious or complex medical conditions.
However, COVID-19 could still negatively affect the operating margins and financial results of the Clinic,
as the duration of the pandemic is unknown.
45

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DocuSign Envelope ID: C076B141-5831-41F8-93B6-4D4900FAAB1F

Beginning of Current Year End of Year

20 Total assets (Part X, line 16) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 20,543,802,362. 22,107,639,425.

4b (Code: ) (Expenses $ 827,331,781. including grants of $ 41,977,512. ) (Revenue $ 8,006,602. )

4c (Code: ) (Expenses $ 299,283,508. including grants of $ 28,393,698. ) (Revenue $ 45,139,476. )

4d Other program services (Describe on Schedule O.)

related (W-2/1099-MISC/ 1099-NEC) organization

Individual trustee or director

Highest compensated employee

Total to Part VII, Section A, line 1c •••••••••••••••••••••••••

Highest compensated employee

Total to Part VII, Section A, line 1c •••••••••••••••••••••••••

Highest compensated employee

Total to Part VII, Section A, line 1c ••••••••••••••••••••••••• 15,922,829. 5,395,612. 2,151,643.

1 a Federated campaigns ~~~~~ 1a

h Total. Add lines 1a-1f •••••••••••••••••• 2,389,724,888.

b EDUCATION 611600 45,139,476. 45,139,476.

c RESEARCH 541700 8,006,602. 4,731,275. 3,275,327.

and sales expenses ~~~

11 a MISC. CONSULTING 541610 10,413,998. 1,781,089. 7,355,576. 1,277,333.

b MISC. REVENUE 900099 7,110,562. 4,787,333. 0. 2,323,229.

232010 12-13-22 Form 990 (2022)

8 Inventories for sale or use ~~~~~~~~~~~~~~~~~~~~~~~~~~ 9,188,537. 8 10,787,335.

trustee, key employee, creator or founder, substantial contributor, or 35%

and complete lines 27, 28, 32, and 33.

Public Charity Status and Public Support

Section C - Distributable Amount Current Year

1 Distributable amount for 2022 from Section C, line 6

SCHEDULE A, PART III, LINE 12, EXPLANATION FOR OTHER INCOME:

2018 AMOUNT: $ 5,805,837.

SCHEDULE A PART I LINE 2:

ORGANIZATION THAT NORMALLY RECEIVES: (1) MORE THAN 33 1/3% OF ITS

SUPPORT FROM CONTRIBUTIONS, MEMBERSHIP FEES, AND GROSS RECEIPTS FROM

ACTIVITIES RELATED TO ITS EXEMPT FUNCTIONS, AND (2) NO MORE THAN 33

TAXABLE INCOME, WE BELIEVE THAT IT ALSO QUALIFIES UNDER THE

CLASSIFICATION OF LINE 2 - A SCHOOL DESCRIBED IN SECTION

170(B)(1)(A)(II), LINE 3 - A HOSPITAL OR A COOPERATIVE HOSPITAL SERVICE

ORGANIZATION DESCRIBED IN SECTION 170(B)(1)(A)(III), AND LINE 7, AN

ORGANIZATION THAT NORMALLY RECEIVES A SUBSTANTIAL PART OF ITS SUPPORT

FROM A GOVERNMENTAL UNIT OR FROM THE GENERAL PUBLIC DESCRIBED IN

232028 12-09-22 Schedule A (Form 990) 2022

Schedule B Schedule of Contributors OMB No. 1545-0047

Name of the organization Employer identification number

MAYO CLINIC 41-6011702

Filers of: Section:

Form 990 or 990-EZ X 501(c)( 3 ) (enter number) organization

4947(a)(1) nonexempt charitable trust not treated as a private foundation

527 political organization

Form 990-PF 501(c)(3) exempt private foundation

4947(a)(1) nonexempt charitable trust treated as a private foundation

501(c)(3) taxable private foundation

Check if your organization is covered by the General Rule or a Special Rule.

MAYO CLINIC 41-6011702

(a) (b) (c) (d)

(a) (b) (c) (d)

(a) (b) (c) (d)

(a) (b) (c) (d)

(a) (b) (c) (d)

(a) (b) (c) (d)

MAYO CLINIC 41-6011702

MAYO CLINIC 41-6011702

(e) Transfer of gift