Republic of the Philippines

Cebu Normal University

Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: [email protected]
Website: www.cnu.edu.ph

DRUG STUDY

Patient's Initials: Date of Admission: Diagnosis:

Age: Height: Weight: Clinical Intervention:
Sex: Ward: Bed No: Name of Physician:

Drug Information Classification Mechanism of Action Indication Contraindications Side Effects Nursing Responsibilities
Generic Name: Pharmacologic Pharmacodynamics or Mechanism of General Indication/s: ● Hypersensitivity to GI: Diarrhea, nausea,
Before Drug Administration:
Piperacillin/Tazobactam Classification: Action: Treatment of moderate to severe piperacillin/tazobactam constipation. ● Check doctor's order.
Penicillin Piperacillin induces a bactericidal effect by bacterial infections, including and any penicillin ● Establish baseline of vital signs,
Trade Name: inhibiting bacterial cell wall binding to community-acquired/nosocomial SKIN: Rash (maculopapular, CBC with differential, basic
Zosyn Therapeutic PCN-binding proteins, which then inhibit pneumonia and intra-abdominal, Precautions: bullous, urticarial, eczemoid), metabolic panel (BMP), liver
Classification: the final step of peptidoglycan synthesis. pelvic, skin, and skin structure ● History of allergies, pruritus. function test (LFT), urinalysis,
Minimum Dose: Antibiotic infections. Tazobactam expands especially to prothrombin time (PT), and
4.5 grams Tazobactam inactivates bacterial piperacillin activity to include cephalosporins and GENERAL: Fever, activated partial thromboplastin
beta-lactamase. This action protects beta-lactamase-producing strains beta-lactamase headache, insomnia. clotting time (aPTT).
Maximum Dose: piperacillin from enzymatic degradation, of S. aureus, H. influenzae, inhibitors ● Perform culture and sensitivity
18 grams extends its spectrum of activity, and Bacteroides, PsAg, ● Renal impairment INJECTION SITE: Phlebitis, before initiation of therapy.
prevents bacterial overgrowth. Acinetobacter, Klebsiella ● Preexisting seizure pain, inflammation,
● Screen allergy history, especially
Patient's Dose: pneumoniae, and E. coli. It can disorder thrombophlebitis, edema. to penicillin and cephalosporins.
4.5 grams Pharmacokinetics: also be used for surgical ● Reconstitute each 1 gram with 5
Protein binding: 16% - 30%. Widely prophylaxis and complicated HEMA: Decreased mL D5W or 0.9% NaCl. Shake
Route: distributed. Readily crosses placenta; intra-abdominal infections. hemoglobin and hematocrit, vigorously to dissolve. Further
IVTT appears in cord blood and amniotic fluid. thrombocytopenia, increased dilute with at least 50 mL D5W or
Distributed in breast milk in low Patient's Indication: platelet count, transient 0.9% NaCl.
concentrations. Primarily excreted Piperacillin/tazobactam is eosinophilia, leukopenia,
unchanged in urine. Removed by prescribed to the patient to treat neutropenia, (+) Coombs' During Drug Administration:
 Republic of the Philippines
Cebu Normal University
Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: [email protected]
Website: www.cnu.edu.ph

Frequency: hemodialysis. Half-life: 0.7 - 1.2 hours pneumonia, which is caused by test results, prolonged ● Verify identity.
Every 6 hours (increased in patients with hepatic Klebsiella pneumoniae, as prothrombin and partial ● Inform regarding the purpose of
cirrhosis and renal impairment). indicated in the patient's culture thromboplastin time the medication and its possible
Availability/Form: and sensitivity test result. side effects.
● Injection powder RENAL: Increased serum ● Inspect IV site for induration and
(2.25 g, 3.375 g, 4.5 g) concentrations of creatinine inflammation. Note for signs of
● Premix Ready to Use and BUN, changes in serum phlebitis (e.g., redness, swelling,
(2.25 g/50 mL, 3.375 electrolytes. pain).
g/50 mL, 4.5 g/100 ● Infuse over 30 minutes. Expanded
mL) HEPATO: Transient increase infusion may take within 3-4
in AST, ALT, alkaline hours.
Contents: phosphatase, and bilirubin.
4 grams piperacillin + 0.5 After Drug Administration:
grams tazobactam Potentially Fatal: Serious, ● Instruct patient and guardian to
anaphylactic reactions, report any side effects of the drug
antibiotic-induced immediately.
pseudomembranous colitis, ● Assess for signs and symptoms of
Stevens-Johnson syndrome, anaphylaxis during the first 15
toxic epidermal necrolysis. minutes.
● Monitor daily pattern of bowel
activity and stool consistency. Mild
GI effects may be tolerable, but
increasing severity may indicate
onset of antibiotic-associated
colitis.
● Monitor for signs and symptoms
of superinfection (e.g., fever,
 Republic of the Philippines
Cebu Normal University
Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: [email protected]
Website: www.cnu.edu.ph

vomiting, diarrhea, anal/genital

pruritus, oral mucosal changes.
● Monitor I&O, urinalysis, renal
function tests, and serum
electrolytes, especially potassium.
● Emphasize importance of
completing full length of therapy
to avoid antibiotic resistance and
recurrence of infection.
● Document and record.

References:
Kizior, R., & Hodgson, K. (2021). Saunders Nursing Drug Handbook 2021. Saunders.
‌Piperacillin + Tazobactam. (2020). Mims.com. https://www.mims.com/philippines/drug/info/piperacillin%20+%20tazobactam?mtype=generic
 Republic of the Philippines
Cebu Normal University
Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: [email protected]
Website: www.cnu.edu.ph

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