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Physio Ex Exercise 6 Activity 5
Physio Ex Exercise 6 Activity 5
3 When the cardiac muscle cell is at rest, where is most of the potassium found? You
Experiment Results
Predict Questions
1 Predict Question 1: Because calcium-channel blockers are negative chronotropic and negative
inotropic, what effect do you think increasing the concentration of calcium will have on heart rate?
2 Predict Question 2: Excess potassium outside of the cardiac cell decreases the resting potential
of the plasma membrane, thus decreasing the force of contraction. What effect (if any) do you
think it will initially have on heart rate?
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01/17/2024 PhysioEx Exercise 6 Activity 5
Experiment Data
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01/17/2024 PhysioEx Exercise 6 Activity 5
3 The ion that had the most pronounced effect on heart rate was You
4 Ectopic pacemakers can be caused by excessive leakage of potassium into cardiac cells,
resulting in pacemakers appearing in abnormal locations in the heart muscle. This hyperkalemia
(excess potassium) decreases the resting potential of the cardiac muscle cell. What effect do you
think this would have on the force of contraction?
Your answer:
The blood is pumped more forcefully and the heart beats more quickly as expected due to an
increase in heart rate and contraction pressure.
2 Describe the effect that increasing the potassium ions initially had on the heart in this
activity. Relate this to the resting membrane potential of the cardiac muscle cell. How well i
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01/17/2024 PhysioEx Exercise 6 Activity 5
Your answer:
As expected, high potassium ions lower the contraction pressure and resting potential.
3 Describe how calcium channel blockers are used to treat patients and why?
Your answer:
They obstruct the flow of calcium through the channels in every action potential path. Reduced
heart rate, peripheral resistance, and contraction pressure are all brought on by decreased
calcium.
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