B.

Pharmacy Question Paper Collection,IOM

For First Year
 B.Pharmacy Question Paper Collection,IOM
For First Year

CONTRIBUTERS:
- AMISH CHAUDHARY [ IOM, 20TH BATCH]
 B.Pharmacy Question Paper Collection,IOM
For First Year

[Anatomy: 2077]
1. Differentiate between a skeletal muscle and smooth muscle. Draw a neat labeled diagram of each of
them. 2+1.5+1.5=5

2. List the organ of urinary system. Draw a well labeled diagram of nephron. Mention the function of
kidney. 1+2+2=5

3. Describe the gross structure of thyroid gland with applied aspects. 4+1=5

4. Explain the extent and gross features of spinal cord. 2+3=5

[Anatomy: Internal Assessment 2077]

1. Classify the connective tissues with two examples of each. Describe the structure of growing long
bone with well labeled diagram. (1.5 + 2.5)

2. Mention the name of primary and secondary lymphoid organs. Describe the gross structure of lungs.
(1+3)

3. Describe the structure of Human Heart with well labeled diagram. Define pericardium and
mediastinum. (3+1)

4. Describe the structure of spinal cord. Classify neuron on the basis of polarity (2+2)

5. Describe the structure of liver with well labeled diagram. Define ductus venosus and liagmentum
teres hepatis. (3+1)

[Physiology: 2077]
1. Define blood. What is the composition of blood? List the functions of blood. 1+2+3=6

2. List the layers of respiratory membrane. Explain the mechanism and factors affecting diffusion of
gases across the respiratory membrane. 1+5=6

3. List the composition and function of pancreatic juice. What is steatorrhoea? 2+3+1=6

4. Explain the effects of growth hormone on different organ system of the body. Mention the feactures
of hypo and hyper secretion of growth hormone. 4+2=6

5. Write short notes on: 4*4=16

a. Functions of kidneys

b. Ovarian cycle

c. Cardiac output
 B.Pharmacy Question Paper Collection,IOM
For First Year
d. Pathophysiology of Mysthenia Gravis

[Physiology: Internal Assessment: 2077]

1. State Landsteiner Law. What are the indications and hazards of blood transfusion? (2+3)

2. What is Erythropoiesis? Explain the factors regulating erythropoiesis. (1+4)

3. Explain the excitation contraction coupling in a skeletal muscle. What is isotonic contraction and
isometric contraction? (3+1+1)

4. Explain the different methods of oxygen transport in blood? List the different types of Hypoxia. (3+2)

5. Explain the mechanism of micturition. What is oliguria and polyuria? (3+1+1)

6. Write the differences between upper motor neuron paralysis and lower motor neuron paralysis. (5)

[Pathology: 2077]
1. Describe the signs and symptoms of viral hepatits. Give its laboratory diagnosis. 2+2=4

2. List the factors causing inflammation. Describe the vascular event in acute inflammation. 2+2=4

3. Write differences between type I and type II diabetes mellitus. 4

4. Explain pathogenesis of peptic ulcer disease. 4

5. Describe pathophysiology of pulmonary tuberculosis. 4

[Pathology: Internal Assessment:2077]

1. Define Neoplasia. Differentiate between benign and malignant tumors.

2. Features of hypothyroidism.

3. Describe type of Shock with examples.

4. Risk factors of Myocardial infarction.

 B.Pharmacy Question Paper Collection,IOM
For First Year
[Pharmaceutical microbiology: 2077]
1. Discuss environmental factors influencing bacterial growth. 10

2. Explain classical pathway of complement activation. 10

3. Explain four different ddisinfectants used in hospitals. 10

4. Describe in brief the mechanism of drug resistance. 10

5. Write down the principle and procedure of Gram stain. 5+5=10

6. Discuss beneficial and harmful roles of normal flora. 5+5=10

7. Write short notes on: 4*5=20

a. Hybridoma technology

b. Kriby Bauer disc diffusion method

c. Transgenic animal

d. Historical development of pharmaceutical microbiology

[Biochemistry: 2077]
1. a. Explain different types of enzyme inhibition. What is the role of Michaelis Menten on this. [6]

b. Discuss the therapeutic and diagnostic role of enzyme. [2]

2. a. Explain with flow chart why anerobic glycolysis gives 2 ATP only?

b. Describe the uses of NADPH.

3. Explain the process of fatty acids oxidation to liberate energy. List the factors that favor ketogenesis.
[6+2=8]

4. Describe the process of detoxification and excretion of: [4+4=8]

a. ammonia

b. bilirubin

5. Describe the process of DNA extraction froma given buccal swab sample. Outline the components of a
polymerase chain reaction. [5+5=8]

6. List four functions for each of the following: [4*2=8]

a. prostaglandins
 B.Pharmacy Question Paper Collection,IOM
For First Year
b. amino acids

c. complex lipids

d. heteropolysachharides

7. Classify fat soluble vitamins. Describe the RDA, sources, biological functions and deficiency
manifestation of fat soluble vitamins. [1+7=8]

8. Define and classify tumor markers. Write a short note on their clinical significance with example.
[6+2=8]

9. Explain the biochemical significance of: [4*2=8]

a. Okazaki fragments in DNA replication

b. Structure of transfer RNA

c. Antibiotics and protein synthesis inhibition

d. Cyclin dependent kinases

10. Write short notes on: [2*4=8]

a. Liver function test

b. Renal function test

[Medicinal Chemistry I: 2077]

1. Explain the Isomerism, Partition coefficient, bioisosterism and hydrogen bonding as physiochemical
properties of a drug molecule. [4*2.5=10]

2. Enumerate the steps involved in the synthesis of the following:

a. Propranolol [5]

b. Ketamine HCl [5]

3. Classify non-steroidal anti-inflammatory agents giving example from each class. Write the structure,
mechanism of action, uses and adverse effects of Paracetamol. [3+7=10]

4. Discuss SAR of hydantoins. Write the synthetic scheme of Carbamazepine. [5+5=10]

5. Explain SAR of sympathomimetic agents with suitable examples. Show MOA of irreversible
cholinesterase inhibitors and cholinesterase reactivators. [5+5=10]

6. Explain SAR of benzodiazepines with suitable examples. Show MOA and synthetic scheme of
Phenobarbitone. [4+3+3=10]
 B.Pharmacy Question Paper Collection,IOM
For First Year
7. Describe stereochemistry and metabolism of steroids. Discuss MOA of Sildenafil Citrate.
[4+3+3=10]

8. Write short notes on: [2*5=10]

a. SAR of morphine analogues b. Phase I and II metabolism

[Pharmacology I: 2077]
1. Classify antihypertensive drugs with example. Write down pharmacological actions, therapeutic uses
and side effects of Amlodipine. 4+2+2+2=10

2. Give the reasons: 2*5=10

a. L-DOPA is always given in combination with Carbidopa.

b. Eating of cheese in forbidden in patients with MAO inhibitor therapy.

3. Define and classify sedative and hypnotics with examples. Discuss the MOA and uses of
Benzodiazepines. 4+3+3=10

4. Write down the MOA and Therapeutics uses of: 2*5=10

i. Risperidone

ii. Digoxin

5. Classify adrenergic drugs with examples. Write the pharmacological effects, therapeutic uses and side
effects of Salbutamol. 4+2+2+2=10

6. What is epilepsy? Discuss the types of epilepsy. Classify antiepileptic agents with examples from each
class. Write the pharmacokinetics, uses, MOA, and side effects of Phenytoin. 2+4+2+2=10

7. Define adverse drug reactions. Describe in detail the different types of ADR with suitable examples.
2+8=10

8. Define haemostasis. Describe in detail the mechanism of action, ADR, monitoring parameters and
uses of oral anticoagulants. 2+3+2+3=10
 B.Pharmacy Question Paper Collection,IOM
For First Year

[Pharmaceutical Chemistry: 2077]

1. What is the importance of limit test in pharmacy? Explain how the sources of impurities can be
minimized. What does impurity do in medical preparations? 3+4+3=10

2. a. Define limit test and explain the limit test of Chloride. 5

b. How many grams of FeSO4.7H2O should be weighed to prepare 250 ml of 20ppm solution of
sodium fluoride? 5

3. Define dentifrices? Classify the dental products and explain the functions of dental products. Explain
test for purity, assay and medical uses of sodium fluoride. 2+4+4=10

4. explain the test for purity, properties, assay and medical uses of:

a. Hydrogen peroxide 5

b. Aluminium hydroxide gel 5

5. Explain the stereochemistry and mechanism of SN1 and SN2 reactions. What happens when 2,2
dimethyl-1,3-bromo butane undergoes reaction through SN1 and SN2 paths? 7+3=10

6. a. Define halohydrin and explain the mechanism for formation of halohydrin. 4

b. How electrophilic addition reaction does differ from free radical addition reaction? Explain the
mechanism. 6

7. Explain in detail with mechanism:

a. Claisen condensation reaction 5

b. Michael addition reaction 5

8. Write short notes on: 2*5=10

a. Conformationsl isomers of n-butane

b. Unimolecular and biomelecular elimination reaction

[Pharmaceutical Chemistry: Internal Assessment:2077]

1. State and explain in detail. (any one) (5)

a. Perkin Condensation reaction

b. Friedel Crafts reaction

 B.Pharmacy Question Paper Collection,IOM
For First Year
2. Differentiate and give detail mechanism for any one. (10)

a. Unimolecular and bimolecular substitution reaction

b. Unimolecular and bimolecular elimination reaction

3. What are the sources of impurities in pharmaceutical substances? Explain the limit test for sulphate
or lead. (10)

4. What are topical gastro intestinal agents? Explain preparation, Test for purity, Assay and Medicinal
uses of ammonium chloride. (10)

Or

5. What are topical agents? Explain preparation, Test for purity, Assay and Medicinal uses of Zinc
sulphate.

6. calculate the weight of heptahydrated ferrous sulphate required to prepare 100ml, 20 ppm sulphate
solution. (5)