MHRequirements EN
MHRequirements EN
Requirements Guide
Notices
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Doc No D0026036 The material contained in this document
DE50653432 is provided “as is,” and is subject to being
October 2022 Revision A.00 changed, without notice, in future
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In This Book
This document details the minimum computer hardware, software, and network
requirements as well as the minimum instrument firmware revisions required to
run an Agilent MassHunter Workstation or Agilent MassHunter Networked
Workstation. Also included are the supported instrument types and Windows
operating system configurations.
Table 1 Terms and abbreviations used in this document
Term Description
2 Network Requirements
This chapter describes the network requirements that must be met in order to
support the environmental computing needs of a MassHunter system.
3 Instrument Connections
This chapter provides information on the instruments supported by the current
revision of MassHunter and the required respective instrument drivers and
firmware revisions.
4 Software Compatibility
This chapter contains information on compatibility with other software.
2 Network Requirements 19
Introduction 20
LAN Connectivity 20
LAN Power Management 21
Firewall Settings 21
Domain Requirements 22
Environments with Proxy Servers 23
Network Isolation 23
Specific Requirements for Compliant Systems 24
3 Instrument Connections 25
RC.NET Drivers and OpenLab CDS 26
Agilent LC 27
Agilent LC/MS 34
Drivers for non-Agilent Instruments 36
Incompatible Instruments and Modules 37
4 Software Compatibility 39
Software 40
Libraries and Databases 41
Computer Hardware 11
Disk Space 11
PC Recommendation 12
This chapter contains the hardware and software requirements for the different
components of a MassHunter system.
Depending on the type of installation, you may need different hardware
components. The following graphics show the required components for each
scenario.
Software
Component Details
* The listed anti-virus software has been tested to be compatible with the MassHunter software described
in this document. While other third-party AV solutions may also be compatible, they have not been tested,
and compatibility cannot be guaranteed.
Windows Compatibility
Computer Hardware
Disk Space
Disk space requirements depend based on the number and type of instruments,
archival frequency, and the method settings chosen for Acquisition. Agilent
recommends providing enough disk space for one year of lab operation, in
addition to the operating system and MassHunter Workstation requirements.
The MassHunter Workstation is available either with storage in the local file
system (MassHunter Workstation) or on a remote OpenLab Server or OpenLab
ECM XT server with built-in Content Management database (MassHunter
Networked Workstation).
Note that on Networked Workstations, data is only temporarily stored in a
secured location on the local computer until it is transferred to the OpenLab
Server/ECM XT server.
PC Recommendation
Processor speed (CPU) Intel Xeon W-2123, 4 core, 3.6 GHz Intel Xeon W-2235, 6 core, 3.8 GHz
Hard disk 1 TB M.2 NVMe SSD - Primary (C:\) Boot. 1 TB M.2 NVMe SSD - Primary (C:\) Boot.
4 TB × 2 RAID1 (4 TB) - Data (D:\) 6 TB × 4 RAID10 (12 TB) - Data (D:\)
USB port* 1 USB port required for installation 1 USB port required for installation
LAN card - House Integrated Intel I217LM PCIe GbE Controller 1 Integrated Intel I217LM PCIe GbE Controller
LAN card - instrument† Integrated Intel I217LM PCIe GbE Controller 1 Intel Ethernet 210-T1 PCle
* If a USB port is not available, the installation media can be copied over the network or downloaded from
https://agilent.subscribenet.com.
† A second LAN interface is required to isolate the instrument's data traffic from the local area network.
Processor speed (CPU) Intel Xeon W-2123 (3.6 GHz, 8.25 MB cache, 4 cores)
Physical memory (RAM) 16GB (2x8GB) DDR4 2666 DIMM ECC Registered Memory
* If a USB port is not available, the installation media can be copied over the network or downloaded from
https://agilent.subscribenet.com.
† A second LAN interface is required to isolate the instrument's data traffic from the local area network.
When setting up a MassHunter computer for the first time, some actions and
settings are required. The MassHunter installer configures Windows 10 with
required and performance settings.
These instructions show Windows 10. The changes apply to Windows 11 as well.
Required Actions
These steps must be taken for a new Windows installation, before the software is
installed.
1 In Control Panel > System, activate Windows with Microsoft.
Do this step only if the computer is customer-supplied. Computers from
Agilent are already activated.
2 In Windows Settings > Update and Security, click Check for updates to check
for updates and apply all patches.
Make sure all updates are downloaded and installed before you proceed.
Make sure that no reboot is pending.
Required Settings
Administrative In Local Security Policy > Local Policies > Security Options:
Tools • Network Access: Sharing and security model for local accounts = Classic -
local users authenticate as themselves.
Date and Time • Time zone of your computer’s location.
Network and In Change adapter settings > Local Area Connection > Properties > Configure >
Sharing Center Power Management:
• All check boxes cleared.
If this procedure does not work as expected, or the computer has no Internet
NOTE access, install .NET 3.5 from the Windows installation media (see details for
Windows 10 in https://support.microsoft.com/en-us/kb/2734782). If you do
not have installation media, create them as described
https://www.microsoft.com/en-us/software-download/windows10.
• .NET Framework 3.5 (includes .NET 2.0 and 3.0) > Windows Communication
Foundation Non-HTTP Activation = selected
This setting makes sure that the net.tcp components are properly initialized,
enable Non-HTTP activation
• .NET Framework 4.6 Advanced Services = selected.
• Telnet Client = selected.
• TFTP Client = selected.
The system must be rebooted after Windows features are turned on.
NOTE
Windows Settings
Performance Options
Control Panel
These Control Panel options enhance your system performance.
This chapter describes the network requirements that must be met in order to
support the environmental computing needs of a MassHunter system.
Introduction
LAN Connectivity
1 Network Interface Card (NIC) teaming is also known as Load Balancing and Failover
(LBFO)
Firewall Settings
If you are using a third party firewall or anti-virus software on the network where
MassHunter is installed, open these firewall ports to allow communication
between the system components of MassHunter. These apply to workstations
as well as to Client/Server systems as component communications rely on these
communication channels:
Table 3. Firewall ports
8085-8089 Alternative to port 8084 if that port is in use by another page or process
8090 Hosts the viewing page of current license grants and consumptions found in the
OpenLab Control Panel administration interface
You will need to disable Windows Defender Firewall when you update the
NOTE firmware.
Domain Requirements
Domains support the flow of information and user access rights across
machines in the network. This means that all machines and instruments within
the MassHunter Networked Workstation system must reside within the same
domain or have the appropriate cross domain trusts to allow name based
communications between all components in the system. In the case of a
workstation installation, domains are only relevant if you are using a Windows
domain-based authentication model. In this case the workstation or client must
always be able to communicate with domain components in order to function as
expected.
Installing MassHunter Workstation will apply network exceptions to the Windows
firewall under the domain profile to result in a functional system. The
components necessary to support MassHunter on a domain are:
• Domain controller – broadcasts the domain name and negotiates access to
machines.
• Domain name server (DNS) – maintains records of what host names belong
to which IP on the network. This component is always required for effective
components communications in networked systems.
• Active directory – maintains the list of users and their access rights on the
domain.
The domain name server (DNS) must be able to resolve the IPv4 address of all
NOTE instrument controllers and instruments. Any unresolved instrument controller or
instrument will disrupt the functionality of MassHunter resulting in errors or
delays. IPv6 is not supported and must be deactivated.
The OpenLab server must be accessible via http or https in the network. If you
use proxy servers, verify that they can be accessed. If required, adjust the proxy
settings.
Network Isolation
If you intend to use your system in a compliant environment, ensure the following
settings related to time synchronization:
• Your network must have a time synchronization service to make sure that all
systems are using a consistent and valid time.
• To ensure that users cannot change the time on a client system, users must
not operate using an administrator account. This is important as the client
time is used during buffered activity logging during network outages.
MassHunter can control instruments and modules that use RC.NET based driver
software only.
Agilent and other vendors may release RC.net drivers independent of the
MassHunter releases. Agilent recommends always using the most recent
firmware revisions which include latest firmware features and improvements.
Agilent driver software is forward compatible with respect to firmware, i.e. the
firmware can be updated without the need of updating the driver or CDS.
More information on instrument drivers and firmware is available in the
respective RC.net driver release notes.
The following Agilent instrument driver software revisions are part of the
MassHunter Acquisition software package, and are installed by default with the
software:
Table 4. Agilent driver packages shipped and installed with MassHunter 12.0
Agilent LC 3.5
Agilent TQ 3.0
Additional RC.NET instrument drivers are supported with MassHunter 12.0 and
will need to be installed separately.
Agilent LC
Recommended Firmware
Agilent recommends using current LC firmware sets with your MassHunter
Workstation. The latest LC firmware sets are 7.xx. See Table 5.
Firmware Set 7.xx can be downloaded from
http://www.agilent.com/en-us/firmwareDownload?whid=99818.
LC and CE firmware revisions are grouped into sets for each module or system.
NOTE Firmware sets include just the latest firmware of each module.
Modules combined into one LC instrument always need to have firmware from
the same set. Firmware of one set is fully compatible with your CDS that
supports this firmware set. However, if one module uses a firmware revision
lower that the specified Minimum Firmware Revision some functionality might
not be supported.
Do not mix firmware revisions from one set with older or newer sets. Firmware is
NOTE not tested across set borders!
Table 5. Recommended firmware
Agilent 1100 Series, 1200 Series and 1200 Infinity B.07.30 or later
Agilent 1200 Series, 1200 Infinity and 1120 Compact LC B.07.30 or later
You need to upgrade all existing modules to the latest version only if
• you add a new LC module to the existing system (recommended).
• one of the existing modules requires an upgrade due to a bug fix solved with
the latest release.
* A host may be required. For details see latest driver release note.
† Cluster with up to three G1316C with integrated 8pos/9port valves (products G4230A/B). Minimum two
G1316C TCCs, the third TCC can be a G1316A, B or C.
Module Version
VTC Valve Combinations of G7116B, G1170A and G1316C (valve or See LC Driver Release Notes:
Thermostat column hosts) and G1316A/B and G7130A Valve-Thermostat Cluster
Cluster
Agilent LC/MS
Recommended Firmware
Always use the most recent Firmware or Embedded Software installation
package that comes with the driver package.
G6224A 6224A Accurate-Mass TOF LC/MS No support for AJS or Dual AJS Source
G6520B 6520B Accurate-Mass Q-TOF LC/MS No support for AJS or Dual AJS Source
G6538A 6538 Ultra High Definition (UHD) No support for AJS or Dual AJS Source
Accurate-Mass Q-TOF LC/MS
If any drivers are available for non-Agilent instruments, they will be available from
SubscribeNet
The following tables summarize selected instruments or modules that can not be
controlled with the current revision of MassHunter Workstation.
Incompatible CE Instruments
MassHunter Workstation cannot be used to control CE Instruments.
Software
1 In a MOBILion MOBIE system, MOBIE EyeOn Software is used to acquire data in HRIM
mode. MassHunter Data Acquisition is used to acquire data in Q-TOF mode.
www.agilent.com
© Agilent Technologies, Inc. 2022
Doc No D0026036
DE50653432
October 2022 Revision A.00