Mascular
Mascular
Canellie Canlas, RMT, MSMT / Jonna Tacsay, RMT, MSMT/ Joshua Ramel, RMT/ Mikhail Valdescona, RMT, MPH
UNIT OUTCOMES
At the end of this Unit, the student is able to:
2. Mesodermal in origin
Quick, Forceful, Usually Voluntary Contraction is involuntary, vigorous, Slow, Involuntary Contractions
Contractions and rhythmic.
SKELETAL MUSCLE / STRIATED MUSCLE
1. Consists of muscle fibers, which are long,
cylindrical multinucleated cells with
diameters of 10-100 μm.
* Myotendinous junctions
ORGANIZATION OF MUSCLE FIBERS
Striations show alternating light and dark bands:
The repetitive functional subunit of the contractile apparatus, the sarcomere, extends from Z
disc to Z disc
ORGANIZATION OF MUSCLE FIBERS
The A and I banding pattern in sarcomeres is due mainly to the regular arrangement of thick and
thin myofilaments, composed of myosin and F-actin, respectively
ORGANIZATION OF MUSCLE FIBERS
Myosin heads bind both actin, forming transient crossbridges between the thick and thin
filaments, and ATP, catalyzing energy release (actomyosin ATPase activity).
ORGANIZATION OF MUSCLE FIBERS
I bands consist of the portions of the thin filaments which do not overlap the thick filaments
in the A bands
ORGANIZATION OF MUSCLE FIBERS
1. A bands contain both the thick filaments and the overlapping portions of thin filaments
2. Presence of a lighter zone in its center, the H zone, corresponding to a region with only the
rodlike portions of the myosin molecule and no thin filaments
SARCOPLASMIC RETICULUM & TRANSVERSE TUBULE SYTEM
Myosin heads detach from thin filaments and return to their prepivot position.
Tropomyosin re-covers active sites, and filaments passively slide back to their relaxed state.
MECHANISM OF CONTRACTION
5. When the impulse stops, calcium ions are actively transported into the sarcoplasmic
reticulum
Tropomyosin re-covers active sites, and filaments passively slide back to their relaxed state.
SKELETAL MUSCLE FIBERS
Different types of fibers can be identified on the basis of (1) their maximal rate of
contraction (fast or slow fibers) and (2) their major pathway for ATP synthesis (oxidative
phosphorylation or glycolysis).
- Small fibers, appear red in fresh specimens, contain many mitochondria and large amounts
of myoglobin and cytochrome complexes
- Slow-twitch fatigue-resistant motor units; (a twitch is a single brief contraction of the muscle)
SKELETAL MUSCLE FIBERS
Type IIa (Fast Oxidative Glycolytic Fibers).
- Fast-twitch fatigue-prone motor units & generate high peak muscle tension
CARDIAC MUSCLE
- Has same types and arrangements of
contractile filaments as skeletal muscle