VECTOR VACCINE

HVT NDV
l
Newcastle Disease
l
Marek’s Disease

Key Advantages

APPROVED SPECIES AGE OF l

ND protection without the use of a
l Chickens ADMINISTRATION conventional live ND vaccine
l SC: 1-day-old chickens l
One-time administration at the
VACCINE TYPE l In ovo: 18- to 19-day-old hatchery saves labor with greater
embryonated chicken eggs consistency of application vs field
l Live HVT vector ND vaccine
administration
l
Effective ND vaccination in the face of
VACCINE CONSTRUCT PACKAGING (PRODUCT CODE)
NDV maternal antibodies
l Vector: Live serotype 3 turkey l 5 ampules per cane
herpes virus (HVT)
l
No respiratory tract damage or
l 1,000-dose ampule (B372H1US)
respiratory reactions, reducing
l Donor Insert: Newcastle 2,000-dose ampule (B372I1US)
Disease virus F protein gene
l
secondary infections that can occur
l 4,000-dose ampule (B372K1US) with live conventional ND vaccines
l
No spreading of the vaccine strain in
DISEASE PROTECTION
the environment
l Newcastle Disease VACCINE PRESENTATION
l Cell associated
l
Allows the use of monovalent
l Marek’s Disease
bronchitis vaccines, improving
l Frozen in liquid nitrogen
bronchitis protection
ROUTE OF l
Marek’s disease protection equal to
ADMINISTRATION QUALITY conventional HVT vaccines
l
Subcutaneous injection l Thoroughly tested for purity, l
Earlier onset of immunity due to faster
l In ovo injection sterility, potency, and safety, HVT replication and greater expression
and compliant with all
applicable USDA and Ceva
of F protein compared to other
standards. vector ND vaccines

See reverse side and package label for

complete use directions and information
VECTORMUNE® 5. A maximum of 3 ampules should be thawed at one time.
After inspecting the diluent and completing all prepara-

HVT NDV tions, the vaccine should be quickly removed from the
Dewar and placed into a clean 80°F (26.5°C) thaw bath.
This step can be repeated until the appropriate dosage has
MAREK’S DISEASE -
been reached. Gentle agitation during the thawing process
NEWCASTLE DISEASE VACCINE
promotes rapid, uniform thawing and evenly distributes
Serotype 3, Live Marek’s Disease Vector
the vaccine in the ampule.
6. Immediately after thawing, mix the vaccine with the
DESCRIPTION
diluent at room temperature (68°-77°F or 20°-25°C). Gently
VECTORMUNE® HVT NDV contains a genetically engineered
draw the vaccine from the ampule with an 18-gauge, 1.5
Marek’s disease vaccine of serotype 3 (turkey herpesvirus or
inch needle and slowly mix with the diluent. Rinse the
HVT) expressing a Newcastle disease key protective antigen.
ampule one time with the diluted vaccine.
This vaccine is recommended for use in chickens as an aid in
7. Immediately use the vaccine and mix occasionally to
the prevention of Newcastle disease and Marek’s disease.
ensure uniform suspension of cells.
This Marek’s disease vaccine containing serotype 3 is
presented in a frozen cell associated form. The cells and virus SUBCUTANEOUS VACCINATION
particles are very fragile and require careful handling to 1. For subcutaneous injection, sterilize the automatic syringe,
prevent damage or loss of titer in order to achieve optimum needles and other accessory equipment by autoclaving or
efficacy. The vaccine is stored and shipped in frozen form in boiling prior to vaccination.
liquid nitrogen. 2. Use a short (3/8 inch or 1/2 inch) 20-gauge needle for
vaccination. Subcutaneously inject 0.2 mL into the back of
STORAGE CONDITIONS
the neck of each chick.
• Vaccine ampules: Store in liquid nitrogen
• Diluent: Store at room temperature between 68 - 77°F IN OVO VACCINATION
(20 - 25°C) 1. The vaccine is administered in ovo to 18- to 19-day-old
embryonated eggs. Read the egg injection system
INDICATIONS
operator’s manual before initiating vaccination. Failure to
The vaccine is recommended for use in healthy one-day-old
follow instructions may result in personal injury, excessive
chicks or in 18- to 19-day-old embryonated chicken eggs as
embryonic mortality and low hatchability. Inoculate each
an aid in the prevention of Newcastle disease and Marek’s
embryo with 1 full dose (0.05 mL or 0.1 mL).
disease. Good management practices are recommended to
2. Sanitize the egg injection system before and after use
reduce exposure to Newcastle disease virus and Marek’s
following the procedures described in the operator’s
disease virus for at least 2 weeks following vaccination.
manual.
PREPARATION AND ADMINISTRATION OF VACCINE NOTICE
Read the directions for use carefully. Instructions must be
This vaccine has been thoroughly tested for safety, purity,
completely followed. Match the vaccine dose size to the
potency, and sterility and is in compliance with all applicable
proper diluent size and route of administration as follows:
USDA and Ceva standards.
1. For subcutaneous injection of day-old chicks: Mix 200 mL
of diluent for each 1000 doses of vaccine. CAUTION
2. For in ovo vaccination of 18- to 19-day-old chicken 1. Read the above directions carefully.
embryos: Mix 100 mL of diluent for each 1000 doses of 2. Do not vaccinate within 21 days before slaughter.
vaccine to administer 0.1 mL per chicken embryo or mix 50 3. The vaccine contains gentamicin and amphotericin B as
mL for each 1000 doses of vaccine to administer 0.05 mL preservatives.
per chicken embryo. 4. Burn containers and all unused contents.
5. Do not remove vaccine from liquid nitrogen until ready for
VACCINE PREPARATION
use.
1. Be familiar with all safety and precautionary measures for
6. Do not refreeze the vaccine.
handling liquid nitrogen to prevent personal injury.
7. Do not use vaccine that has thawed in the liquid nitrogen
2. Wear gloves, a plastic face shield and protective goggles
container.
before removing vaccine ampules from the liquid nitrogen.
8. Do not overdose or over dilute the vaccine
3. Check the container to confirm a sufficient amount of
9. The effect of combining this vaccine with other products is
liquid nitrogen is present to keep the vaccine frozen.
not known and could impact vaccine efficacy.
If thawed, do not use the vaccine. The containers (Dewars)
must be checked regularly for liquid nitrogen level and
must be refilled as needed. Manufactured by:
Biomune Company
4. After matching the dose size of the vaccine with the
diluent size, quickly remove the exact number of ampules Distributed by:
needed. Ceva Animal Health, LLC Tel: 913-894-0230
8735 Rosehill Road, Ste. 300 www.ceva.us
Lenexa, KS 66215
All trademarks are owned by Ceva Santè Animale S.A. and its affiliates.