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Co Occurring Mental Illness and Substance Use Disorders A Guide To Diagnosis and Treatment 1st Edition Jonathan D Avery John W Barnhill
Co Occurring Mental Illness and Substance Use Disorders A Guide To Diagnosis and Treatment 1st Edition Jonathan D Avery John W Barnhill
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Co-occurring
MENTAL ILLNESS and
SUBSTANCE USE
DISORDERS
A GUIDE TO DIAGNOSIS
AND TREATMENT
Edited by
Jonathan D. Avery, M.D.
John W. Barnhill, M.D.
CO-OCCURRING MENTAL ILLNESS
and
SUBSTANCE USE DISORDERS
A Guide to Diagnosis and Treatment
CO-OCCURRING MENTAL ILLNESS
and
SUBSTANCE USE DISORDERS
A Guide to Diagnosis and Treatment
Edited by
PART 1
THE INITIAL INTERVIEW AND
COMPREHENSIVE ASSESSMENT
PART 2
CO-OCCURRING DISORDERS
4 Anxiety Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Rebecca A. Nejat, M.D., and Maria Andrea Baez, M.D.
6 Psychotic Disorders . . . . . . . . . . . . . . . . . . . . . . . . . 69
Bernadine H. Han, M.D., M.S., and Jonathan D. Avery, M.D.
7 Personality Disorders . . . . . . . . . . . . . . . . . . . . . . . . 83
John W. Barnhill, M.D., and Jonathan D. Avery, M.D.
8 Attention-Deficit/Hyperactivity Disorder . . . . . . . . . 93
Sean X. Luo, M.D., Ph.D., and Frances R. Levin, M.D.
PART 3
SPECIFIC TREATMENTS
PART 4
SPECIAL POPULATIONS
15 Adolescence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
Shannon G. Caspersen, M.D., M.Phil.
16 Geriatrics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
Caitlin Snow, M.D.
18 Incarceration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
Lauren Stossel, M.D.
vii
viii Co-occurring Mental Illness and Substance Use Disorders
xi
xii Co-occurring Mental Illness and Substance Use Disorders
ments. Given the number of psychiatric disorders and the number of sub
stances of abuse, the potential clinical complexity can feel overwhelming
to clinicians, families, and patients. Fortunately, there are straightfor
ward approaches to this complexity.
Let’s consider a difficult but fairly routine case of co-occurring disor
ders. David is a 19-year-old man who presents for an evaluation after
being arrested for selling MDMA (ecstasy) at a rave party. His affluent par
ents were able to get the criminal charges dropped, but they desperately
want help for their son. David has been smoking marijuana almost daily
since age 12 and has, in recent years, developed a daily habit of alternat
ing cocaine and heroin in order to “fine tune” his mood. He sells ecstasy at
rave parties in order to gain access to money, parties, drugs, and women.
David has successfully taken amphetamine for his attention-deficit/
hyperactivity disorder (ADHD) (combined presentation), which he, his
parents, and his teachers agreed was helpful. A recent psychiatrist dis
continued the amphetamine out of concern for abuse, though David
insisted that he tended to be “short” on the amphetamine by the end of the
month, not because he sells or over-uses, but because Sally, his 17-year-old
sister, steals his supply. Sally had always been “perfect,” but ever since a
difficult breakup with a possibly abusive boyfriend, she has become
moody and “way too skinny.”
David, himself, attends classes at a local junior college. He made B’s
in high school but missed about half of the school days between ninth
and twelfth grades so that he earned a GED rather than a high school di
ploma. David has briefly seen several psychotherapists, has recurrently
tried 12-step programs, and has, in the past year, twice relapsed imme
diately after 30-day drug rehabs. David’s parents are in the midst of a
stormy divorce fueled by the father’s persistent risk taking, irritability,
and sexual indiscretions. The father averages a liter of vodka every
2 days, which he says is the only thing that can get him to sleep. David’s
mother is depressed and anxious and averages about 4 mg of clonaze
pam each day. David says he is a “clean needle fanatic” and insists that
he will never get HIV, but he describes himself as a “nocturnal nihilist”
with little hope that he’ll live to reach age 21.
How best to approach David’s complexity? One option is to identify a
single problem as the focus for treatment. For example, David might be
seen to have cocaine, heroin, and marijuana use disorders and be referred
to either a 12-step program or a drug rehab. This approach has already
failed multiple times, however, and so it might be useful to broaden the
diagnostic possibilities to include undiagnosed and untreated depres
sive, anxiety, and/or insomnia disorder. The only co-occurring disorder
that has received clinical attention appears to be ADHD, and a recent
Introduction xiii
You have options in reading this casebook. You can read the 18 cases
and discussions straight through. The cases do not depend on one another,
however, and so you might start with a case that sounds interesting or
about which you have a specific interest. The accompanying questions
can be used to test your knowledge after you have read the chapter, though
the questions can also be read prior to reading the chapter in order to
help organize your reading. However it is used, we hope that this case
book can improve the experience of the clinicians who work with this
population and improve the lives of the many people who suffer with
these co-occurring disorders.
3
4 Co-occurring Mental Illness and Substance Use Disorders
This early phase of the interview is, thus, a time for the clinician to de
velop an alliance and begin to silently develop a differential diagnosis,
a history of the present illness, and a mental status examination (MSE).
A broad assessment effort is especially important in patients with co
occurring disorders, because evidence indicates that it is best to treat—or
at least explicitly recognize—co-occurring disorders from the outset of the
intervention.
Pressured for time, the busy clinician may decide to forgo this initial,
open-ended phase in the pursuit of symptom clarification. Without a
broad understanding of the patient’s complaints, however, this clinician
may develop a focused understanding of one aspect of the patient but
miss other diagnoses as well as the patient’s own concerns.
Although open-ended curiosity is generally the most effective initial
strategy during this initial phase, some patients are unable to open up
until asked some “warm-up” questions (e.g., demographic informa
tion). Still other patients are unable or unwilling to reveal sensitive in
formation soon after meeting someone. Each interview is a bit different,
and so the interviewer will likely have to remain flexible to be effective.
The later phase of the interview is focused on the interviewer’s effort
to convert the patient’s story into the interviewer’s own history of the pres
ent illness (HPI). This is an active process that requires the clinician to
elicit and synthesize an assortment of patient behaviors and symptoms,
bits of semi-reliable collateral information, possible comorbidities, un
spoken hypotheses, prior (mis)diagnoses, and psychiatric, medical, so
cial, family, and developmental histories.
Central to this reinterpretation of a patient’s story into an HPI is the
interviewer’s ability to shift from a relatively open-ended “conversation”
into more active, directive questioning. Interviewers make this transition
in different ways, but it is often useful for the interviewer to directly in
dicate that he or she would like to pursue some specific details for a few
minutes. This phase of data acquisition may involve a manualized as
sessment tool as described in Chapter 2, or it may be a more sponta
neously intuitive process. Although the goal of the initial interview may
be to arrive at a wonderfully robust three-dimensional picture of the pa
tient, it can be helpful to recall that no initial interview is ever complete:
additional information is likely to emerge as the relationship develops,
as collateral information emerges, and as the patient’s behaviors and
symptoms evolve during the ensuing weeks and months. In other words,
the interviewer need not feel pressured to completely “get” the patient
during the initial interview.
For example, in Chapter 5 (“Posttraumatic Stress Disorder”), Joe pres
ents with the problematic use of alcohol and marijuana. A former soldier,
6 Co-occurring Mental Illness and Substance Use Disorders
Conclusion #1
Assessment/Diagnosis: Alcohol use disorder, depressed.
Plan: AA.
Conclusion #2
Assessment: Asked to evaluate a 50-year-old man for depres
sion and alcohol abuse. He was seen to evaluate “depression”
on day 3 of an unexpected hospitalization for acute, perforated
appendicitis. He appears to have become depressed in the con
text of gradually escalating use of alcohol over the past 2 years.
Functioning poorly at work and in his marriage. No suicidality,
according to patient and wife. Aside from some tremor on hos
pital days 2–3, no withdrawal symptoms during this past week’s
hospitalization, though his currently heightened dysphoria might
reflect withdrawal. Patient denies depression prior to 2 years
ago, though he has strong family history of depression in multi
ple relatives. He claims that he shifted from drinking a few beers
per week to a six pack every night just after his mother died,
which was 2 years ago. Now drinks approximately 1–2 pints of
vodka per day. MCV 100; AST/ALT: 85/40. Patient educated
about several medication options (e.g., acamprosate, naltrex
one, antidepressant medication, disulfiram) and treatment op
tions (inpatient and outpatient rehabs, individual therapy) during
the hospitalization. Patient strongly prefers to first try AA and
then consider individual psychotherapy if his depression per
sists and/or he restarts drinking.
Diagnosis: Alcohol use disorder, moderate. Alcohol-induced
depressive disorder.
Plan: AA.
The Initial Interview 11
KEY POINTS
Questions
Reference
Mani N, Slevin N, Hudson A: What Three Wise Men have to say about diagno
sis. BMJ 343:d7769, 2011 22187188
Suggested Readings
Barnhill J: The psychiatric interview and mental status exam, in The American
Psychiatric Publishing Textbook of Psychiatry, 6th Edition. Edited by Hales
RE, Yudofsky SC, Roberts LW. Washington, DC, American Psychiatric Pub
lishing, 2014, pp 3–30
MacKinnon RA, Michels R, Buckley PJ: The Psychiatric Interview in Clinical
Practice, 3rd Edition. Arlington, VA, American Psychiatric Association
Publishing, 2016
Miller WR, Rollnick S: Motivational Interviewing: Preparing People for Change,
3rd Edition. New York, Guilford, 2012
2
THE COMPREHENSIVE
ASSESSMENT
13
14 Co-occurring Mental Illness and Substance Use Disorders
Clinical Case
Douglas is a 45-year-old single male referred by his primary care
provider for psychiatric evaluation and care. Douglas agreed
to the evaluation because he has lost his job, is out of money,
has no social supports, and has psychiatric symptoms and sub
stance use that are increasingly problematic. His concerns can
be divided into four categories: a preoccupation with mind con
trol, mood and anxiety complaints, the use of psychoactive sub
stances, and serious psychosocial stressors.
Douglas’s most pressing and chronic concern relates to a
sense that his mind is being controlled by people who are in
serting thoughts, directing his behavior, and conducting exper
iments on him. He believes that 10 years ago a computer chip
was somehow implanted in his head while he was sleeping.
On awakening, he started to hear voices that comment on his
actions or discuss what he will do next. At times the voices are
overwhelming and prevent him from sleeping or concentrating
at work. He feels agitated by these taunting voices. He be
lieves that his friends and family were secretly involved with the
insertion of the computer chip, so he cut contact with everyone
he knew 5 years earlier.
He denies a family history of addictive disorders or mental
illness. He had been taking antipsychotic and antidepressant
medications for short periods in the past but stopped because
The Comprehensive Assessment 15
I II
Psychiatric Substance use Psychiatric Substance use
disorder: disorder: disorder: disorder:
LOW LOW HIGH LOW
severity severity severity severity
LOC: client served by primary care LOC: client served by mental health
clinic center
III IV
Psychiatric Substance use Psychiatric Substance use
disorder: disorder: disorder: disorder:
LOW HIGH HIGH HIGH
severity severity severity severity
Discussion
In the 12-step process for evaluation of CODs (Table 2–1), the first step is
to engage the patient. Eliciting the patient’s perspective of his problem
and desired treatment will help the provider to determine the degree of
insight and willingness to accept treatment. The provider should be em
pathetic and offer hope and desire to work with the patient and treat
ment team to figure out the best plan of action.
Step 2 is to identify collaterals and request signed releases of information in
order to gather more information. Although Douglas is isolated from friends
and family, he has been treated by a variety of physicians. It will be im
portant to identify those providers and review their assessments and treat
ment trials. A strong alliance may be able to overcome Douglas’s possi
ble reluctance to involve prior clinicians, especially if he recognizes that
such information may allow a more effective plan of treatment.
Step 3, screening and detecting for CODs, can be tricky when patients
have poor insight into illness. It is important to understand the chronol
ogy and course of his symptoms and the details of his substance use,
though the approach needs to be tactful and may not be completed during
the first visit. The assessment should include the severity of each substance
use problem and mental illness. In Douglas’s case, his methamphetamine
use disorder was severe, but he appears to have attained long-term re
mission without formal treatment. He uses cannabis and alcohol daily,
and they appear to be having a negative impact on his mental health.
His psychosis appears to have been precipitated by his past metham
phetamine use, but it may also be that the current psychosis was induced
by or is associated with his cannabis and alcohol use.
Douglas has significant psychotic, depressive, and anxiety symptoms.
It is possible that all of these symptoms are part of a primary psychosis
18 Co-occurring Mental Illness and Substance Use Disorders
other clients in the program. Additional support in the future can be de
veloped through 12-step groups.
Step 8 is to identify strengths and supports. It is important to recognize
that Douglas has strengths. He has a strong work ethic and had, until re
cently, successfully maintained employment despite chronic psychosis.
He has never been psychiatrically hospitalized or attempted suicide. He
successfully stopped using methamphetamines without addiction treat
ment. These indicate that he has reasonably intact impulse control. Al
though in this case, Douglas denies any social supports, this should be
reevaluated as he gains trust and rapport with his treatment team. It is
important to identify family members, treatment providers, friends, and
organizations that the patient identifies as supportive in his or her life. If
patients are socially isolated, the treatment team will often become their
primary support.
Although the case does not focus on identifying cultural needs and sup
port (Step 9), areas to explore include ethnicity, religious background
and beliefs, gender identity and sexual orientation, learning disabilities,
and educational level.
Step 10 is to identify additional problem areas to address.
Medical issues are potentially significant. Douglas’s hepatitis C and
history of intravenous methamphetamine use indicate a need to screen
for additional diseases such as HIV disease, syphilis, and tuberculosis,
as well as to investigate medical causes of psychosis and medical com
plications of his substance use. Screening labs should include urine
toxicology as well as a comprehensive metabolic panel including liver
function, renal function, electrolytes, blood sugar or hemoglobin A1C,
and thyroid function tests, as well as a complete blood count. Many co
occurring disorder programs are integrated and have medical providers
associated with the program. After Douglas is engaged with his team, he
should establish care with and be evaluated by a primary care provider.
He should also be screened for dental problems, because severe tooth
decay and gum disease are common in persons with methamphetamine
dependence.
A vocational evaluation is a key element of a comprehensive COD pro
gram. Douglas is recently unemployed. Finding immediate employ
ment might interfere with or even derail his psychiatric and addiction
treatment, so the clinician should probably help him get short- or long
term disability. At the same time, Douglas wants to get a job, and so his
recovery plan must include vocational and educational placement and
support.
Housing is an important concern, since Douglas is unable to pay his
rent. He would likely resist residential addiction and psychiatric care be
The Comprehensive Assessment 21
KEY POINTS
Questions
1. What is a core reason to use the Four Quadrant Model of Care for
Co-occurring Disorders?
Reference
Center for Substance Abuse Treatment: Substance Abuse Treatment for Persons
With Co-occurring Disorders. Treatment Improvement Protocol (TIP) Se
ries 42 (DHHS Publ No SMA-05-3992). Rockville, MD, Substance Abuse
and Mental Health Services Administration, 2005
PART 2
CO-OCCURRING DISORDERS
3
DEPRESSIVE AND
BIPOLAR DISORDERS
25
26 Co-occurring Mental Illness and Substance Use Disorders
with mania may try to reduce insomnia or agitation with sedating med
ications or try to trigger the pleasurable symptoms of hypomania with a
stimulant. Other people with a mood disorder may just take whatever
substance is available in order to change their mood symptoms (Amer
ican Psychiatric Association 2013).
Not only do mood and substance use disorders commonly co-occur
in the same individual, either diagnosis worsens the prognosis of the
other. Each disorder is also associated with elevated risks of serious ad
verse outcomes such as accidental injury and suicide, with the greatest
risk in persons with both classes of disorder. Although the body of re
search guiding best practices in the treatment of these co-occurring con
ditions is growing, many questions remain.
The third iteration of the National Epidemiologic Survey on Alcohol
and Related Conditions (NESARC-III) provides a measure of prevalence
and comorbidity rates for mood and substance use disorders. According
to this survey, the 2012–13 lifetime prevalence of an alcohol use disorder
in the United States was almost 30%; 13.9% of Americans had a lifetime
history of severe alcohol use disorder, and 13.9% had exhibited any alcohol
use disorder in the past year (Grant et al. 2015). The lifetime prevalence
of a drug use disorder was nearly 10%, with 6.6% having a moderate
to-severe drug use disorder and nearly 4% meeting past-year criteria
(Grant et al. 2004). Depressive and bipolar disorders are also common,
with 9.3% meeting past-year criteria for any mood disorder (over 7%
with past-year depression and 1.7% with mania in the past year) (Grant
et al. 2016). Mood disorders are strongly associated with having a severe
alcohol use disorder (odds ratio [OR]=1.8) or a moderate-to-severe drug
use disorder (OR=2.2) in the past 12 months (Grant et al. 2004, 2015).
We present the case of a man with cocaine use and mood symptoms to
illustrate common diagnostic challenges and to demonstrate a treatment
approach for those with co-occurring depressive or bipolar disorders and
SUDs.
Clinical Case
Robert is 36-year-old attorney presenting at the urging of his
husband, who unexpectedly came home during a weekday
and discovered Robert smoking cocaine in their living room.
Robert reports a 5-year history of cocaine use, beginning with
casual use at a party with colleagues from his law office. He
describes a pattern of use that was initially in his words “rec
reational,” using intranasally every 1–2 weeks on Friday or
Saturday nights. Shortly thereafter, he began to take an occa
Depressive and Bipolar Disorders 27
Discussion
This case illustrates some of the diagnostic challenges inherent to the co
occurrence of mood symptoms and SUDs. Individuals like Robert who use
stimulants may induce symptoms that mimic bipolar disorder through a
pattern of manic-like intoxication followed by withdrawal resembling de
pression. At the same time, individuals with SUDs are known to be at in
creased risk for both major depression and bipolar disorder. Robert shows
further risk factors, including a family history of mood disorders, as well
as a personal history of at least one major depressive episode preceding
onset of cocaine use disorder. This information allows a diagnosis of major
depressive disorder at the initial assessment but raises concern that the
28 Co-occurring Mental Illness and Substance Use Disorders
true diagnosis may be bipolar disorder. Robert also presents with symp
toms consistent with a moderate-to-severe cocaine use disorder.
Clarifying the diagnostic question of an independent versus a sub
stance-induced mood disorder in the presence of continuous drug or al
cohol use is challenging. In this situation, it can be helpful to retrospec
tively review for historical symptoms during periods of abstinence,
particularly periods lasting 30 days or longer. Substance-induced mood
symptoms typically resolve over that time course. Likewise, careful fam
ily history can contribute to a full picture of the risk of an independent
mood disorder. Nonetheless, it is important to note that many of those
individuals initially diagnosed with substance-induced depression or
mania will eventually be diagnosed as having an independent depressive
or bipolar disorder (Tolliver and Anton 2015).
Patients presenting with histories of depressive or manic symptoms
should undergo thoughtful, thorough examinations. Table 3–1 lists facets
of the history that require particular attention in this population. Major
depression, substance use disorders, and particularly bipolar disorders
are all associated with significant elevation in suicide risk (Tolliver and
Anton 2015). Continual assessment of suicide risk, starting at the initial
assessment, is therefore essential.
History, physical examination, and laboratory testing facilitate as
sessment of medical factors contributing to mood symptoms. These
may include thyroid illness, adrenal insufficiency, and other endocrine
illnesses; hepatic, pulmonary, or renal disease; metabolic abnormalities;
nutritional deficiencies; occult infections; and certain cancers. Sudden
onset of behavior changes could reflect a neurological condition, such as
dementia (especially the behavioral variant of frontotemporal demen
tia), multiple sclerosis, or stroke.
General screening tests are listed in Table 3–2, as are tests that may be
pursued based on information gathered during the history and physical
examination. Urine toxicology screening is generally advisable, because
many persons with SUDs may be using multiple substances. Those who
use stimulants will also commonly use sedatives such as alcohol, opi
oids, or benzodiazepines to moderate unpleasant sensations that occur
as the initial euphoria begins to subside. Hence, cocaine use disorders
co-occur with alcohol use disorder with a particularly high frequency. In
addition, tobacco use disorder is very common among individuals with
other SUDs and among those with mood disorders.
Collateral sources of information can be useful in the assessment of de
pressive and bipolar disorders and SUDs. Bipolar disorder manifests with
both subjective symptoms and outward signs; the patient may have lim
ited awareness of the latter, while familiar contacts can describe periods of
Depressive and Bipolar Disorders 29
2 bushels of corn.
1 bushel of wheat.
5 pounds of sugar.
½ pound of tea.
10 pounds of beef.
25 pounds of pork.
1 good turkey.
3 pounds of butter.
1 pound of coffee.
1 bushel of potatoes.