Addisons Disease
Addisons Disease
Addisons Disease
Addison's disease
Addison's diseaseis an endocrine
Addison's disease
It mobilizes nutrients, regulates the
Addison's disease
Approximately 70% of cases of Addisons
ETIOLOGY
Secondary adrenocortical insufficiency
ACTH deficiency from pituitary disease
suppression of hypothalamic-pituitary axis by
corticosteroid treatment for nonendocrine disorders
causes atrophy of adrenal cortex
Treatment with daily administration of corticosteroids
for 2 to 4 weeks may suppress function of the adrenal
cortex; therefore, adrenal insufficiency should be
considered in any patient who has been treated with
corticosteroids.
surgical removal of both adrenal glands
infection of the adrenal glands - TB
ETIOLOGY
Inadequate aldosterone produces
disturbances of sodium,potassium, and water
metabolism
Cortisol deficiency produces
abnormal fat, protein, and carbohydrate
metabolism
no cortisol during a period of stress can
precipitate addisonian crisis, an exaggerated
state of adrenal cortical insufficiency, and can
lead to death.
ETIOLOGY
Causes of adrenal insufficiency can be grouped by
SIGNS AND
SYMPTOMS
water loss, dehydration and hypovolemia
muscular weakness, fatigue, weight loss
GI Problems-- anorexia, nausea, vomiting,
Addisonian crisis
With disease progression and acute hypotension, the
DIAGNOSIS
Blood test
Hypoglycemia
Hyponatremia
Hyperkalemia
leukocytosis
MEDICAL MANAGEMENT
Restoration of normal fluid and electrolyte balance:
Protecting wellbeing
Minimize stressful situation
Protect patient from infection