Anti Fungal: Dr. Dr. Nico L Lumbuun, SPFK
Anti Fungal: Dr. Dr. Nico L Lumbuun, SPFK
• SUPERPHYICIAL
Griseofulvine, Azole derivatives, Tolnaftate, Nystatin
FUNGAL INFECTIONS
Systemic
• Incidence - increasing trend
• Slow onset
• Difficult to diagnose & eradicate
• Long duration of therapy
7
AMPHOTERISIN B
Mechanism of Action :
The polyene antifungal
bind with sterols in the
fungal cell membrane,
principally ergosterol.
This causes the cell's
contents (K+) to leak out
and the cell dies
SPECTRUM OF AMPHOTERICIN B
• Fungistatic & fungicidal (depends on dose)