Vaccine Safety
Vaccine Safety
10PD019
Vaccines are among the most cost-effective and effective public
health interventions and have led to considerable decline in
vaccine-preventable diseases.
PROPOTIONAL REPORTING
RATIO METHOD
Simple
Ease of implementation and interpretation
Hence widely used measure in Vaccine
adverse event reporting systems(VAERS)
Historically ad hoc epidemologic studies were
used to assess potential vaccine adverse
events.
Newer projects based on automated large-
linked databases provide a more flexible
framework for hypothesis testing than ad hoc
studies.
Hence CDC initiated Vaccine Safety Datalink
(VSD) project in 1990.
This study prospectively collects vaccination, medical
outcome( hospital discharge, outpatient visits, emergency
room visits, and deaths) and covariate data (e.g. birth
certificates, census) under joint protocol at multiple HMOs.
VSD focused its initial efforts on examining potential
associations between immunizations and a number of
neurologic, allergic, hematologic, infections, inflammatory
and metabolic conditions and conducted a surveillance on
approximately 500,000 children from birth through 6 yrs of
age.
VSD is also used to test new ad hoc vaccine safety hypothesis,
VAERS, changes in immunization schedules, or introduation
of new vaccines.
VSD provides essential, powerful, costeffective complement
to ongoing evaluations of vaccine safety in the US.
VSD is limited in capacity to assess
association between vaccination and adverse
event with delayed or insidious onset(
neurodevelopmental behavior or behavioral
outcomes)