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Diabetic Neuropathy

WEIGHT/GLUCOSE MANAGEMENT AND LIFESTYLE ADJUSTMENT TO ENSURE POSITIVE


OUTCOMES ACROSS THE LIFESPAN
BY CEE ALSOS
Outline
• What is Diabetes? What
is Diabetic Neuropathy?
• How does nerve damage
affect ADLs?
• Posture, movement,
autonomic function

• Symptoms
• Treatments
• Research
Diabetes Mellitus and Neuropathy*
disease or dysfunction of one or more peripheral nerves, typically
causing numbness or weakness.

 Diabetes Mellitus
 A metabolic disease, affects how our cells
(don’t) utilize glucose, our body’s primary
energy source
 Type 1 “Autoimmune” Diabetes Mellitus the
pancreatic islets do not produce enough
Insulin to manage blood glucose
 Type 2,formerly “acquired” Diabetes Mellitus
-cells become resistant to high blood glucose
concentration, no longer respond to presence
of Insulin
 Long term deprivation of energy gradually
degrades and damages all cells and tissues
Applied Concepts

 What are nerves, and what do they do?


 Highly specialized, power hungry cells
that communicate messages from the
brain and spinal cord by way of
electrical signals, or neurotransmitters
to effectors (organs, glands,
tissues/muscles)
 Damage to nerve tissue causes
 High noise/signal ratio
 Dropped signal
 And remember – Damage = PAIN!
Symptoms

Peripheral Neuropathy Autonomic Neuropathy Additional Types


Most common type. Affects the Affects the autonomic nerves, • Charcot’s joint
nerves in the hands, feet, legs and which control the bladder,
arms. Generally starts in the feet,
• Cranial Neuropathy – may
intestinal tract, and genitals
tends to start in both feet at once, affect vision
among others
Tingling
• Compression Mononeuropathy
• • Heartburn, vomiting
undigested food, loss of bowel • Femoral Neuropathy – atrophy
• Pain or Increased Sensitivity
control may result
• Numbness or Weakness • Incontinence, UTIs • Focal Neuropathy
• Other • Erectile Dysfunction, • Thoracic/Lumbar Radiculopathy
• Change in shape of feet decreased libido & pain
• Unilateral Foot Drop
• Open sores/ulcers • CV problems
Treatment

 No current treatments can repair nerve damage if it


occurs
 Nerve damage is at current irreversible, but effective
training may lend to neuroplasticity improving
physiological functioning and health outcomes
 Medications can reduce the pain, numbness and
tingling sensation inherent in peripheral neuropathy.
Medications can also treat the undesirable symptoms
of autonomic neuropathy, and training can improve
voiding urinary bladder and bowels.
Research

 The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy
 study demonstrated that mesenchymal stem cells (MSCs) or resveratrol (RSV) may improve diabetic
hyperglycemia and neuropathy. The aim of the present study was to investigate the combined effect of
MSCs and RSV on DN.
 Compared with the diabetic control group, the blood glucose of mice in the MSCs, RSV (until day 35)
and MSCs + RSV groups were decreased following therapy (P<0.05). Blood glucose in the MSCs and
MSCs + RSV group reached a normal level at day 14, and this was maintained until the end of the
experiment; no significant differences were identified in the blood glucose levels between the two
groups.
 Evaluation of various risk factors associated with multidrug-resistant organisms isolated from diabetic foot
ulcer patients
 Diabetic foot ulcer patients are often infected with multidrug resistant organisms (MDRO) due to
inappropriate antibiotic treatment, chronic course of the wound, frequent hospital admission,
neuropathy, nephropathy, and peripheral vascular disease. Furthermore, due to peripheral arterial
disease, there is poor penetration of antibiotics into the lower limb tissue, thereby promoting selection
of resistant bacterial strains.
Conclusion

 The simplest and most effective


method of preventing Diabetic
Neuropathy is managing body
weight, monitoring blood glucose
levels, and increasing physical
activity
 The NIH also recommends a dilated
eye exam once per year
 Glaucoma, or excessive pressure in
the eye can damage the retinas and
the optic nerves and cause blindness
1. DIABETES MELLITUS TYPE 2
A. AFFECTS ONLY OLDER, OVERWEIGHT PEOPLE
B. AFFECTS OUR BODY'S ABILITY TO UTILIZE GLUCOSE,
ITS PRIMARY ENERGY SOURCE
C. IS NOT A PREMIER CONCERN AMONG HEATH CARE
PROFESSIONALS
D. ALL OF THE ABOVE.
2. ONCE NERVE DAMAGE OCCURS IT CAN BE REPAIRED

Multiple Choice
BY CURRENT MEDICAL TREATMENTS.
A. TRUE
B. FALSE.
Questions: 3. DIABETIC NEUROPATHY
A. DAMAGES TISSUES NOURISHING AND SUPPORTING
NERVES, LEADING TO GRADUAL DEGENERATION OF
SKIN, MUSCLE AND NERVOUS TISSUE.
B. REDUCES THE AVAILABILITY OF GLUCOSE REQUIRED
FOR NERVES TO PERFORM THEIR FUNCTION.
C. BOTH A AND B.
D. NONE OF THE ABOVE.

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