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Fat Soluble Vitamins: A, D, E, K: Stefania Widya S
Fat Soluble Vitamins: A, D, E, K: Stefania Widya S
A, D, E, K
STEFANIA WIDYA S.
Fat Soluble Vitamins
SLIDE 2
• Being insoluble in the watery GI juices, the fat-soluble vitamins
require bile for their digestion and absorption.
• Upon absorption, fat-soluble vitamins travel through the
lymphatic system within chylomicrons before entering the
bloodstream, where many of them require protein carriers for
Overview transport.
• The fat-soluble vitamins participate in numerous activities
throughout the body, but excesses are stored primarily in the
liver and adipose tissue.
• By the same token, because fat-soluble vitamins are not readily
excreted, the risk of toxicity is greater than it is for the water-
soluble vitamins.
Free Retinol
Retinol
Micelle
complex
Liver
Enterocytes
1 μg RAE = 1 μg retinol
= 2 μg beta-carotene (supplement)
= 12 μg beta-carotene (dietary)
= 24 μg of other vitamin A precursor
carotenoids
Most food and supplement labels report their vitamin A contents using International Units (IU)
• IU retinol = 0.3 μg retinol or 0.3 μg RAE AKG Vitamin A:
• 1 IU beta-carotene (supplement) = 0.5 IU retinol or 0-6 mo = 375 mcg Pregnant : +300 mcg
0.15 μg RAE 7mo-3y0 = 400 mcg Lactating : +350 mcg
• 1 IU beta-carotene (dietary) = 0.165 IU retinol or 0.05 4-6 yo = 450 mcg
μg RAE 7-9 yo = 500 mcg
• 1 IU other vitamin A precursor carotenoids = 0.025 μg 10-18 yo = 600 mcg
RAE 19->80 yo = 500 mcg
Vitamin D
Vitamin E
Source of Vitamin K
• vitamin K is made in the GI tract by the billions of bacteria that normally reside
there.
• Once synthesized, vitamin K is absorbed and stored in the liver. This source
provides only about half of a person’s needs.
• Vitamin K–rich foods such asgreen vegetables and vegetable oils can easily
supply the rest.
Assignment
Make a paper with this topic :
1. Absorption, utilization, and metabolism of vitamin A
2. Role of Vitamin A in vision, protein synthesis, growth, immune system, and reproduction
3. Effect of deficiency and toxicity of Vitamin A
4. Absorption, utilization, and metabolism of Vitamin D
5. Role of Vitamin D in bone mineralization
6. Absorption, utilization, and metabolism of Vitamin E
7. Role of Vitamin E as antioxidant
8. Absorption, utilization, and metabolism of Vitamin K
9. Role of Vitamin K in blood clotting
10.Food source of fat soluble vitamin
That’s all. Thank you very much!
Any Questions?