Quality Control-RED PACOP

Quality control 1 and 2 (PACOP
REVIEWER)
1. Acceptable glassware to be used to deliver an
exact volume of a certain standard solution to be
used for titration:
A. Beaker D. Analytical balance
B. Buret E. Volumetric flask
C. Graduated cylinder
Answer:B. Buret
Knevel,A.M. and F.E. DiGangi.1997.Jenkins
Quantitative Pharmaceutical Chemistry 7th
Edition.McGraw-Hill:New York p.58
2. An inert type of stainless steel used in
dissolution apparatus recognized by the US
A. Type 114 D. Type 489
B. Type 239 E. All of the
choices
C. Type 316
Answer: C. Type 316
United States Pharmacopeial
Convention,Inc.The United States Pharmacopeia
30th edition and The National Formulary 25th
Revision CD-ROM
3. Volumetric apparatus designed to contain a
definite volume of liquid:
A.Beaker D.Volumetric flask
B.Buret E. B and C
C. Pipet
Answer: D. Volumetric flask
4. Titrant employed for non-aqueous
alkalimetric titration:
A.Ammonium Hydroxide
B. Hydrochloric Acid VS
C. Perchloric Acid in Glacial Acetic Acid VS
D. Potassium Hydroxide VS
E. Sodium Methoxide VS
Answer: E. Sodium Methoxide VS
5. USP specifies that the standardization of
Sodium Hydroxide VS should be done using
______ as standard:
A.Hydrochloric Acid VS
B. Sodium Carbonate
C. Tromethamine
D. Potassium Biphthalate
E. Potassium Dichromate
Answer: D. Potassium Biphthalate
6. Gravimetric analysis is an appropriate method
for:
A. Determination of Atropine content of
Belladonna leaf
B. Assay of Sodium Chloride, USP
C. Assay of Zinc Chloride, USP
D. Assay of Sodium Nitrite, USP
E. Assay of Sulfurated Potash, USP
Answer: E. Assay of Sulfurated Potash, USP
7. Volhard Method in volumetric precipitation
involves the use of what indicator?
A. Eosin TS
B. Ferric Ammonium Sulfate TS
C. Phenolphthalein TS
D. Potassium Chromate TS
E. Orthophenanthroline TS
Answer: B. Ferric Ammonium Sulfate TS
8. Nitrogen content determination of foods and
pharmaceuticals involves what method?
A.Fajan’s method
B. Gay-Lussac method
C. Kjeldahl method
D.Gravimetric method
E. Winkler method
Answer: C. Kjeldahl method
9. Fat constant that states the degree of
unsaturation in fats and fixed oils:
A. Polenske number D. Iodine number
B. Koettsdorfer number E.Acetyl number
C. Unsaponifiable matter
Answer: D. Iodine number
10. In potentiometric titration, the equivalence
point in the first derivative plot is signified by:
A. The steepest part of the curve
B. The line that crosses 0 in the x axis
C. Maxima or minima of the plot
D. Sharp change in pH reading
E. Change in color of the
solution
Answer: C. Maxima or minima of the plot
Edition.McGraw-Hill:New York p.374-375
11. An instrument that measures the durability
of tablets to withstand shock and abrasion
during transport:
A. Hardness tester D. Polarimeter
B. Caliper E. Friabilator
C. Analytical balance
Answer: E. Friabilator
Allen L.V.,et al.2011 Ansel’s Pharmaceutical
Forms and Drug Delivery System.9th ed. Wolters
Kluwer: Philadelphia.p.233
12. USP definition of negligible:
A. A quantity of not exceeding 0.25 mg
B. A quantity of not exceeding 0.50 mg
C. A quantity of not exceeding 2.5 mg
D. A quantity of not exceeding 5.0 mg
E. None of the choices
Answer: B. A quantity of not exceeding 0.50 mg
Revision CD-ROM
13. An example of drying oil:
A. Cod liver oil D. Sesame oil
B. Olive oil E. Lard
C. Coconut oil
Answer: A. Cod liver oil
14. Orthophenanthroline TS undergoes a color
transition from ______ to ______:
A. Colorless to pink D. White to black
B. Yellow to red E. Blue to yellow
C. Red to blue
Answer: C. Red to blue
15. A tightly closed container of suitable size and
design that maintains an atmosphere of low
moisture content by means of appropriate
drying agents:
A. Desiccator
B. Muffle furnace
C. Oven
D. Glass stoppered bottle
Answer: A. Desiccator
Revision CD-ROM
16. Apparatus used for determination of
alcohol-soluble extractives of benzoin:
A. Acetylization flask
B. Cassia flask
C. Babcock bottle
D. Soxhlet apparatus
E. Clavenger apparatus
Answer: D. Soxhlet apparatus
17. Calculate the normality factor for 0.1N Sodium
Thiosulfate VS given the following data: Weight
of Potassium Dichromate=0.2256g Volume of
titrant consumed during standardization=34.55mL
Volume of titrant consumed during blank
determination=0.05mL Molecular Weight of
Sodium Thiosulfate=248.19g/mol Molecular Weight
of Potassium Dichromate=294.18g/mol
A. 1.5801 D. 1.3337 B. 0.2635
E. 1.8153 C. 0.6669
Answer: D. 1.3337
18. Titrant used for the official assay of ascorbic
acid dosage forms:
A. Sodium Tetraphenylboron VS
B. Iodine VS
C. Potassium Hydroxide VS
D. Disodium Edelate VS
E. Dichlorophenol-Indophenol VS
Answer: E. Dichlorophenol-Indophenol VS
19. Equivalence factor for potassium
permanganate as an oxidizing agent:
A. 2 D.10
B. 3 E. 23
C. 5
Answer: C. 5
20. Assay of volatile oil which involves bisulfate
addition method:
A. Olive oil D. Peppermint spirit
B. Caraway oil E. Clove oil
C. Lemon oil
Answer: B. Caraway oil
21. A glassware usually used in gravimetric
analysis that has a perforated bottom upon
which is bedded of asbestos that is used for
separation of precipitates by use of suction
filtration:
A. Aspirator D. Soxhlet apparatus
B. Buchner funnel E. Reflux condenser
C. Gooch Crucible
Answer: C. Gooch Crucible
22. For samples which contain 50-100% of the
active constituent, the difference in percent
between two determinations should be:
A. 0.03-0.05% D. 0.30-0.45%
B. 0.10-0.20% E. Not more than 3%
C. 0.20-0.25%
Answer: C. 0.20-0.25%
23. In analytical chemistry, cleaning solution is
basically a solution containing:
A. Nitric acid D. Chromic acid
B. Joy® E. Liquid Sosa®
C. Sodium phosphate
Answer: D. Chromic acid
24. pH-adjusting agent used in EDTA titrations
using Dithizone TS as indicator:
A. 3N HCL
B. CH3COOH-CH3COONa buffer
C. NH3-NH4Cl buffer
D. 1N NaOH
E. Any of the choices
Answer: B. CH3COOH-CH3COONa buffer
25. Acid color of phenol red:
A. Colorless D. Yellow
B. Red E. Green
C. Blue
Answer: D. Yellow
26. Reducing titrant that is susceptible to
bacterial degradation:
A. Oxalic Acid VS
B. Potassium Permanganate VS
C. Sodium Thiosulfate VS
D. Ferrous Ammonium Sulfate VS
E. Ceric Sulfate VS
Answer: C. Sodium Thiosulfate VS
27. Actual indicating species in the assay of
Hydrogen Peroxide Topical Solution:
A. Free iodine extracted by chloroform
B. Intense purple color of permanganate ion
C. Blue color of starch-iodo complex
D. Use of Diphenylamine TS as indicator
Answer: B. Intense purple color of
permanganate ion
28. A piece of soft rubber tubing fitted to the
end of a glass rod. It is used to loosen from the
walls of the containing vessel adhering particles
that are not removable by a stream of water
from the wash bottle:
A. Erlenmeyer flask D. stirring rod
B. Policeman E. Watchglass
C. Spatula
Answer: B. Policeman
29. Assay involves an acidimetric type of
titration:
A. Determination of total alkalinity of NaOH
B. Phosphomolybdate assay for phosphates
C. Assay of Precipitated Sulfur using oxygen flask
combustion
D. Assay of Cupric Sulfate
E. Assay of Zinc Chloride
A. Determination of total alkalinity of NaOH
B. Knevel,A.M. and F.E. DiGangi.1997.Jenkins
30. Extraction of alkaloids could be done by
using:
A. Clavenger apparatus D. Separatory funnel
B. HPLC E. Spectrophotometer C.
Brine shrimp assay
Answer: D. Separatory funnel
31. Stability projection for shelf life of
pharmaceuticals are commonly based on
______ equation:
A. Arrhenius equation
B. Clausius-Clapeyron equation
C. Dieterici equation
D. Henderson-Hasselbalch equation
E. Van Deemter equation
Answer: A. Arrhenius equation
32. A plot of the absorbance of the analyte vs.
wavelength which determines the λmax at which
the absorbance of the standard and unknown
solutions will be made:
A. Beer’s plot
B. Planck’s constant
C. Rf value
D. Spectral absorbance curve
Answer: D. Spectral absorbance curve
33. A suitable detector for radioactive samples:
A. UV detector D. Vanillin reagent
B. Echelette grating E. Iodine vapour
C. Geiger-Muller Counter
Answer: C. Geiger-Muller Counter
34. Type of crucible that can withstand high
temperature and is suitable for use in ignition of
drugs and precipitates:
A. Borosilicate Glass D. B and C
B. Sintered crucible E. A, B and C
C. Porcelain
Answer: C. Porcelain
35. In the official assay, Boric Acid, NF acts as a
strong monobasic acid due to the addition of
what sugar alcohol:
A. Erythritol D. Sorbitol
B. Glycerol E. Xylitol
C. Mannitol
Answer: B. Glycerol
36. Measures the free fatty acid present in a
given sample of fats of fixed oil:
A. Acid Value
B. Ester Value
C. Crude Fiber
D. Iodine Value
E. Unsaponifiable Matter
Answer: A. Acid Value
37. Assay method for Sodium Hypochlorite
Solution, USP:
A. Acidimetry
B. EDTA titration
C. Iodometry
D. Permanganometry
E. Volumetric precipitation
Answer: C. Iodometry
38. Official method of water content
determination of pharmaceutical samples:
A. Azeotropic distillation D. A and C
B. Gravimetric determination E. A, B and C
C. Karl Fischer method
Answer: E. A, B and C
Revision CD-ROM
39. Analyte that involves an alkalimetric type of
assay:
A. Magnesium Sulfate D. 2-Phenoxyethanol
B. Sodium Chloride E. Selenium Sulfide
C. Hydrogen Peroxide Solution
Answer: D. 2-Phenoxyethanol
40. Most popular indicator electrode for pH
determinations that involves the exchange of
hydrogen ions on its surface:
A. Standard Hydrogen Electrode
B. Glass electrode
C. Fluoride electrode
D. Quinhydrone electrode
E. Calomel electrode
Answer: B. Glass electrode
41. The use of potassium chromate TS as
indicator in Volumetric precipitation is also
known as the ______ method:
A. Fajan’s Method D. Dumas Method
B. Gay-Lussac Method E. Volhard
Method C. Mohr Method
Answer: C. Mohr Method
Chatten,L.,ed 2008 (reprint). Pharmaceutical
Chemistry Volume 1: Theory and Application.
CBS Publishers and Distributors: India.p.131
42. An aqueous solution composed of potassium
iodide and red mercuric iodide used for the
detection of alkaloids:
A. Dragendorff’s reagent D. Valser’s reagent
B. Hubl’s reagent E. Wagner’s reagent
C. Mayer’s reagent
Answer: D. Valser’s reagent
43. The reciprocating cylinder, basket apparatus
and paddle apparatus are used for what in-vitro
test for tablets?
A. Assay D. Dissolution
B. Content Uniformity E. Friability
C. Disintegration
Answer: D. Dissolution
Revision CD-ROM
44. In weight variation test for tablets, a 5.0%
difference in average tablet weight is accepted
for tablets with an average weight of:
A. 130 mg or less D. A and B
B. 130 mg to 324 mg E. A, B and C
C. More than 324 mg
Answer: C. More than 324 mg
Lachman,L, et.al. 1976. The Theory and Practice
of Industrial Pharmacy. 2nd ed. Lea and Febiger:
Philadelphia.p.349
45. In what case/s will addition of nitrobenzene
be unnecessary in Volhard analysis?
I. Determination of chloride
II. Determination of bromide
III. Determination of iodide
A. I only D. III only B. II and III
E. I, II and III C. I and II
Answer: B. II
46. Solve for the acid number of a 2g sample of
cod liver oil which required 4.5mL of 0.02 KOH
in the titration.(MW of KOH 56.11g/mol):
A. 0.25% D. 2.5mg/g
B. 2.5% E. 0.25mg/g
C. 25mg/g
Answer: D. 2.5mg/g
47. Diazotization assay is used for analysis of
what class of analytes?
A. Mercaptans D. Cyanides
B. Sulfonamides E. Volatile oils
C. Alkaloids
Answer: D. Cyanides
48. Optical rotation is measured using what
instrument?
A. Refractometer D. Polarimeter
B. ph meter E.Spectrophotometer
C. HPLC
Answer: D. Polarimeter
49. Masking agent that permits the
determination of Mg+2 in the presence of Al+3
ions:
A. Absolute alcohol
B. Ammonium Fluoride
C. Triethanolamine
D. Potassium Sodium Tartrate
E. Nitric acid
Answer: C. Triethanolamine
50. A parameter that checks the homogeneity of
the active ingredient in tablets and is usually
done by assaying a certain number of tablets
individually:
A. tablet hardness D. Content Uniformity
B. Tablet thickness E. Weight variation
C. Dissolution
Answer: D. Content Uniformity
Lachman,L, et.al. 1976. The Theory and Practice
of Industrial Pharmacy. 2nd ed. Lea and Febiger:
Philadelphia.p.349
51. Insufficient sulphuric acid added to the
analyte solution during permanganate titration
will:
A. Will turn the solution intense purple
B. Promote formation of a brown precipitat
C. Will discharge the color of permanganate ion
D. Promote completion of the reaction
E. Will turn the solution green
Answer: B. Promote formation of a brown
precipitate
52. EDTA titration using dithizone TS as indicator
should be conducted at what pH?
A. 2 D. 10
B. 4.6 E. 13
C. 7
Answer: B. 4.6
53. The water content of an 875.4mg samle of
dried neem leaves was determined with a
moisture analyzer. What is the % w/w H2o in
the leaves if the final mass was found to be
545.8mg?
A 1.60% D. 98.40% B.
37.85% E. 5.42% C. 62.35%
Answer: B. 37.85%
Edition.McGraw-Hill:New York p.226-227
54. This value represents the percentage of test
material which is volatilized and driven off under
the condition specified:
A. Water content Determination
B. Ignition to constant weight
C. Loss on drying
D. Loss on ignition
E. Acid insoluble ash
Answer: D. Loss on ignition
55. Potassium biphthalate is a primary standard
used for standardization of ______:
A. Sulfuric Acid VS
B. Sodium Hydroxide VS
C. Ammonium Thiocyanate VS
D. Potassium Permanganate VS
E. Disodium Edetate VS
Answer: B. Sodium Hydroxide VS
56. Type of chromatography wherein the mobile
phase is polar in nature and the stationary
phase is nonpolar in nature:
A. Thin layer chromatography
B. Ion-exchange chromatography
C. Normal phase chromatography
D. Reversed-phase chromatography
E. Paper chromatography
Answer: D. Reversed-phase chromatography
57. Tromethamine is a primary standard used
for the standardization of what VS?
A.Sodium NitriteVS D. Silver NitrateVS
B.Ammonium ThicyanateVS E.Perchloric AcidVS
C. Sulfuric AcidVS
Answer: C. Sulfuric Acid VS
Revision CD-ROM
58. Stationary phase in paper chromatography:
A. Cellulose D. Water
B. Acetic acid E. Methanol
C. Acetonitrile
Answer: D. Water
59. Method of detection for TLC:
A. Iodine vapour D. Vanillin Reagent
B. Sulfuric acid E. All of the choices
C. UV lamp
Answer: E. All of the choices C. UV lamp
60. What does G stand for in silica gel G?
A. Gauss D. Gall
B. Germanium E. Ghrelin
C. Gypsum
Answer: C. Gypsum
61. Purpose of potassium iodide in preparation
of Iodine VS:
A. To protect iodine from microbial degradation
B. To permit dissolution of iodine in water
C. As an Antioxidant
D. A and B
E. A, B and C
Answer: B. To permit dissolution of iodine in
water
62. Iodometry is a suitable method for:
A. Ascorbic acid D. Sugar alcohol
B. Mercaptans E. Antimony K Tartrate
C. Sulfites
Answer: D. Sugar alcohol
63. Suitable form of starch for the preparation
of Strach TS:
A. Arrowroot starch
B. Soluble Starch
C. Starch with high α-amylose content
D. A and B
E. A, B and C
Answer: D. A and B
64. Reagent added during preparation of
Sodium Thiosulfate VS that imparts stability to
the volumetric solution by acting as an
antimicrobial preservative and suppresses acid-
catalyzed hydrolysis of the volumetric solution:
A. Hydrochloric acid D.Carbon tetrachloride
B. Sodium bicarbonate E. Starch
C. Sodium carbonate
Answer: C. Sodium carbonate
65. Volumetric solution that is used for analysis
of vitamin C raw material according to USP:
A. Potassium Arsenite VS
B. Sodium Nitrite VS
C. Iodine VS
D. Dichlorophenol-indophenol VS
E. Ceric Sulfate VS
Answer: C. Iodine VS
66. Preservative in Starch TS:
A. Sodium thiosufate D. Carbon disulfide
B. Red mercuric iodide E. Arsenic trioxide
C. Saliva
Answer: B. Red mercuric iodide
Revision CD-ROM
67. Titrant which involves the formation of
iodine monochloride during titration:
A. Iodine VS
B. Perchloric acid Vs
C. Potassium iodate VS
D. hydrochloric acid VS
E. Sodium Thiosulfate VS
Answer: C. Potassium iodate VS
68. Koppeschaar’s Solution:
A. 0.1N Bromine VS
B. Chlorine Water
C. 0.1N Iodine VS
D. Phosphoric Acid
E. Ammonium Phosphomolybdate TS
Answer: A. 0.1N Bromine VS
69. A 1.4500g sample of liquefied phenol was dissolved in
enough water to make 1000mL. A 30mL sample of the
solution was treated with 30mL of 0.1 N Bromine Vs and
HCL. The mixture was treated with potassium iodide and
titrated with 7.38mL of 0.1N sodium Thiosulfate VS. It
was also found that 21mL of 0.1N Sodium thiosulfate VS
was required in the titration of the iodine liberated when
20mL of 0.1N bromine VS was treated with KI and HCL.
Calculate the % phenol in the sample. (MW
phenol=94.11g/mol)
A. 29.00% D. 65.56%
B. 86.99% E. 13.33%
C. 8.70%
Answer: B. 86.99%
70. What is the pH of a 0.400M HNO3 solution?
A. 0.40 D. 4.12
B. 2.05 E. 1.67
C. 0.60
Answer: A. 0.40
71. calculate the NaHCO3 content of a 1.2500g
sample of a mixture containing sodium carbonate
and sodium bicarbonate requiring 13.80mL of
0.5250N HCL on titration to phenolphthalein
endpoint and an additional 16.30mL on further
titration to a methyl orange endpoint.(MW
NaHCO3=84.01g/mol)
A. 61.4% D. 30.7%
B.8.82% E. 70.22%
C. 17.64%
Answer: B.8.82%
72. When organic compound is placed on a very
high magnetic field, the protons absorb radiant
energy and produce characteristics peaks due to
the organic groups associated with the protons:
A. UV spectrophotometry D. HPLC
B. Colorimetry E. Polarography
C. Nuclear Magnetic Resonance
Answer: C. Nuclear Magnetic Resonance
73. Method in Iodine Value determination which
employs the use of Iodobromide Ts as source of
iodine:
A. Hanus method D. Karl Fischer method
B. Hubl’s method E. Winkler method
C. Wij’s method
Answer: A. Hanus method
Revision CD-ROM
74. A polarity scale of solvent arranged
according to increasing eluting power:
A. Electromotive series D. pH scale
B. Eluotropic series E. Partition coefficient
C. Irving-Williams scale
Answer: B. Eluotropic series
75. The assay of Opium for % Morphine content
is an example of:
A. Limit Test D. Identification Test
B. Trace Constituent Analysis E. Proximate Assay
C. Ultimate Assay
Answer: C. Ultimate Assay
76. An unknown sample of a soluble sulphate
weighing 1.8000g yielded 0.9000g of barium
sulphate. Calculate the % sulfur present in the
unknown. (MW of barium sulfate=233.40g/mol,
MW of sulfur=32.06g/mol).
A. 6.87% D. 3.43%
B.7.28% E. 14.56%
C. 13.74%
Answer: A. 6.87%
77. The acid value of a certain fixed oil is .96 and
the ester value is 2.48. What is the
saponification number of the sample?
A. 0.50 D. 7.44
B. 2.48 E. 12.30
C. 3.72
Answer: D. 7.44
78. Unsaponifiable matter in the plant matter
may represent:
A. Unsaturated fatty acid D. Silica
B. Paraffin E. Rancidity
C. Phytosterol
Answer: C. Phytosterol
79. Alcoholic hydroxyl groups present in fatty
acids is estimated using what fat constant?
A. Acetyl value D. Iodine value
B. Acid value E. Ester value
C. Unsaponifiable matter
Answer: A. Acetyl value
80. Assay which involves back titration:
A. alkalimetric determination of esters
B. Total alkalinity of fixed alkalis
C. Determination of chloride by fajan’s method
D. EDTA titration of zinc ion
E. Determination of peroxide by permanganate
method
Answer: A. alkalimetric determination of esters
81. An example of drying agent used in
desiccators:
A. Anhydrous calcium chloride
B. Solid potassium hydroxide
C. Phosphorus
pentoxide
D. Silica gel
E. All of the choices
Answer: E. All of the choices
82. Appropriate glassware to be used in the
assay of cupric sulfate, USP:
A. Beaker D. Iodine flask
B. Buret E. Volumetric flask
C. Erlenmeyer flask
Answer: D. Iodine flask
83. Reproducibility of data within a series of
results is usually reported as:
A. Absolute error D. t-test
B. Relative error E. Q-test
C. Standard deviation
Answer: C. Standard deviation
84. Appropriate indicator for a strong acid-weak
base titration:
A. Phenolphthalein D. Diphenylamine
B. Methyl red E. Starch
C. Eriochrome black T
Answer: A. Phenolphthalein
85. Several acids, dissolved in a solvent, are
completely ionized. The solvent can be classified
as a ______ solvent:
A. Differentiating D. Protophilic
B. Leveling E. Aprotic
C. Protogenic
Answer: B. Leveling
86. Analyte that is can be assayed by ferric
chloride titration:
A.Antimony potassium tartrate
B. Precipitated sulfur
C. Sodium Fluoride
D. Titanium Dioxide
E. Vanadyl Sulfate
Answer: C. Sodium Fluoride
Edition.McGraw-Hill:New York p..
87. Assayed by iodimetry:
A. Iodine Tincture for Iodine Content
B. Sodium Thioglycollate
C. sodium metabisulfite
D. A and B
E. A, B and C
Answer: E. A, B and C
88. Equivalence factor when arsenic trioxide is
used for standardization of iodine VS:
A. 1 D. 4
B. 2 E. 5
C. 3
Answer: D. 4
89. Titrations involving oxidation of sugar
alcohols involve the use of what oxidizing
agent?
A. Ammonium thiocyanate D. Oxalic acid
B. Potassium periodate E. Sodium
thiosulfate C.
Potassium permanganate
Answer: B. Potassium periodate
90. Titrimetric assay for ferrous salts employ
what method?
A. Cerimetry D. Precipitimetry
B. Acidimetry E. Gravimetry
C. Iodometry
Answer: A. Cerimetry
91. Equivalence factor for sodium thiosulfate:
A. 1 D. 6
B. 2 E. 10
C. 3
Answer: A. 1
92. Determination of bulk density of a power
can be done using:
A. Scott volumeter D. A and B
B. Graduated cylinder E. A, B and C
C. Viscometer
Answer: D. A and B
Revision CD-ROM
93. Assayed by precipitation as calcium oxalate,
conversion to oxalic acid and titrating with
acidified permanganate:
A. cherry juice for malic acid
B. sodium nitrite
C. titanium dioxide
D. Selenium sulfide
E. hydrogen peroxide topical solution
Answer: A. cherry juice for malic acid
94. Formes a chelate with divalent and
multivalent cations:
A. Ammonia D. Oxalate ion
B. Ededate ion E. All of the choices
C. Fluoride ion
Answer: B. Ededate ion
95. Extrction using two immiscible solvents
using a separatory funnel is governed by
_______:
A.Le Chatelier’s principle
B. Nernst’s law
C. Rf value
D. common-ion effect
E. Law of entropy
Answer: B. Nernst’s law
96. Organic precipitant employed for the assay
for MgO content of magnesium citrate oral
solution:
A. Cupferron D. DMG
B. Nitron E. Ferroin
C. Oxine
Answer: C. Oxine
97. A parameter that denotes the nearness of
the experimental dta of the true value:
A. Accuracy D. Ruggedness
B. Deviation between trials E. B and C
C. Precision
Answer: A. Accuracy
98. Chromatography is useful for:
A.Resolution of mixtures into constituents parts
B.ID test
by comparing the unknown to a standard
C. Determination of homogeneity
D. Indication of molecular structure
E. All of the choices
99. Examples of in-plane bending vibration of
atoms:
A. Scissoring and twisting
B. Rocking and wagging
C. Wagging and twisting
D. scissoring and rocking
E. All of the items mentioned
Answer: D. scissoring and rocking
100. Appropriate weighing vessel for liquid
samples:
A.Beaker D. Dropper bottle
B. Weighing bottle E. Volumetric flask
C. Watchglass
Answer: D. Dropper bottle
101. Faulty calibration of laboratory apparatus
can result in what type of error?
A. Systematic, methodic error
B. Systematic, instrumental error
C. Indeterminate, personal error
D. Indeterminate, absolute error
E. Gross
Answer: B. Systematic, instrumental error
102. What is the pH of a 0.1M solution of acetic
acid? (Ka=1.75x10-5):
A. 5.00 D. 7.00
B. 2.88 E. 9.24
C. 4.76
Answer: B. 2.88
103. the direct or residual titrimetric
determination of organic or inorganic acids
using an accurately measured volume of base:
A. Acidimetry D. Precipitimetry
B. Alkalimetry E. Oxidimetry
C. Potentiometric titration
Answer: B. Alkalimetry
104. the current official assay for aspirin tablets
employs what method?
A. Residual alkalimetry D. HPLC
B. TLC E. bioassay
C. UV spectrophotometry
Answer: D. HPLC
Revision CD-ROM
105. Alcohol content determination in the USP
involves ______ step to separate the alcohol from
the sample matrix followed by determination of
_____ to determine its concentration:
A. HPLC, viscosity
B. Extraction using immiscible solvent, TLC
C. Distillation, specific gravity
D. Soxhlet extraction, optical rotation
E. Acetylization, titration
Answer: C. Distillation, specific gravity
Revision CD-ROM
106. An instrument that produces ions the
substance under investigation, separates them
according to m/z (charge to mass) ratio, and
records the relative abundance of each ionic
species present:
A. NMR D. HPLC
B. MS E. Fluorimeter
C. FTIR
Answer: B. MS
Revision CD-ROM
107. Riboflavin assay:
A. HPLC D. Turbidimetry
B. TLC E. Colorimetry
C. Fluorimetry
Answer: C. Fluorimetry
Revision CD-ROM
108. if an air-dried drug containing 10%
moisture 2.5% ash calculated ion the basis of
the air-dried drug, what percent of ash would
the moisture-free drug contain?
A. 25% D. 6.25%
B. 4% E. 7.5%
C. 2.25%
Answer: C. 2.25%
109. Reagents that are used to prepare Bromine
VS:
A.Bromine and water
B. Bromine and potassium bromide
C. potassium bromide and potassium bromate
D. Potassium hypoiodite and potassium
perbromate
E. Potassium bromide and hydrochloric acid
Answer: C. potassium bromide and potassium
bromate
110. If a 10.0mL sample of clove oil yields 1.4mL
of residual liquid in a cassia flask, what is the %
eugenol content of the sample?
A. 14% D. 86%
B. 28% E. 100%
C. 43%
Answer: D. 86%
111. Assayed for ketone content:
A. Caraway oil D. A and B
B. Spearmint oil E. A, B and C
C. Cinnamon oil
Answer: D. A and B
112. Saponifying agent used for the analysis of
volatile oils and fixed oils:
A. alcohol KOH VS D. A and B
B. NaOH VS E. A, B and C
C. strong ammonia solution
Answer: A. alcohol KOH VS
113. Used to determine the content of inorganic
impurities in an organic substance. This involves
a procedure to measure the amount of
substance not volatilized from a sample when
the sample is ignited in the presence of sulfuric
acin:
A. Total ash D. A and C
B. Loss on drying E. A, B and C
C. Residue on ignition
Answer: C. Residue on ignition
Revision. CD-ROM
114. type of ionization in mass spectrometry which
involves a high energy beam of neutral atoms,
typically Xe or Ar, causing ionization of the sample.
This is useful for determination of molecular
weight:
A.Electron impact
B. Chemical ionization
C. Fast atom bombardment
D. MALDI-TOF
E. Electrospray ionization
Answer: C. Fast atom bombardment
Beringer,Paul,ed., Remington: The Science and
Practice of Pharmacy.21st ed. Lippincott Williams
and Wilkins Philadelphia.p.636
115. The microbial assay for niacin and calcium
pantothenate employs:
A. Lactobacillus plantarum
B. Lactobacillus leichmannii
C. Pediococcus acidilactici
D. Streptococcus pyogenes
E. Streptomyces venezuelae
Answer: A. Lactobacillus plantarum
116. test animal used in pyrogen testing:
A. Cat D. Horseshoe crab
B. Dog E. rabbit
C. guinea pig
Answer: E. rabbit
117. IR region that is used in the identification of
functional groups sucs as carbonyl, amino and
hydroxyl groups, present in an organic
compound:
A. Fingerprint region
B. Radiofrequency region
C. Group frequency region
D. Absorption spectrum
E. Near-IR region
Answer: C. Group frequency region
118. Samples to be subjected to titration should
consume approximately how many mL of titrant
such that errors in buret readings and weighings
will not be significant?
A. 5mL D. 30mL
B. 8mL E. 45mL
C. 15mL
Answer: D. 30mL
119. A sample of sodium bicarbonate powder
weighs 5.6424g. The powder was transferred to a
graduated cylinder and its volume was 8.5mL. the
graduated cylinder was tapped repeatedly
following USP guidelines and the volume of the
powder after tapping was 4.2 mL. what is the
hausner ratio of the powder?
A. 0.49 D. 6.35
B. 2.00 E. 35.7
C. 2.25
Answer: A. 0.49
Revision. CD-ROM
120. Elastomeric closures are assayed by:
A. Agar diffusion test D. Elution test
B. Cylinder plate method E. leaker test
C. Bacterial endotoxins test
Answer: B. Cylinder plate method
121. Vitamins assayed by fluorometric method:
A. Thiamine D. A and B
B. Riboflavin E. A, B and C
C. Cyanocobalamin
Answer: D. A and B
122. A nitrometer is employed in:
A.Column Chromatography
B. Soxhlet extraction
C. Gasometric analysis
D. NMR
E. Polarography
Answer: C. Gasometric analysis
123. The biological assay for digitalis employs
what test animal?
A. Rats D. Pigeons
B. Guinea pigs E. rabbit
C. dogs
Answer: D. Pigeons
124. Gonad-stimulating principle of placental
origin prepared from the urine of pregnant
women:
A. Estrogen D. Vasopressin
B. Chorionic gonodotropin E. Progesterone
C. Human growth hormone
Answer: B. Chorionic gonodotropin
125. Equivalence factor for dichromate ion
when it acts as an oxidizing agent:
A. 2 D. 7
B. 3 E. 10
C. 6
Answer: C. 6
126. Assayed residually by EDTA titration:
A.Calcium carbonate
B. Aluminum hydroxide
C. Zinc sulfate
D. Acetic acid
E. Sodium thiosulfate
Answer: B. Aluminum hydroxide
127. Spectrometric method tha measures the
amount of light scattered by a suspension:
A. Spectophotometry D. Colorimetry
B. Turbidimetry E. Flame photometry
C. Nephelometry
Answer: C. Nephelometry
128. Sodium and potassium ions are determined by this
method which involves the emission of energy of a
particular wavelength when diluted solution of a metallic
ion is sprayed into a colorless flame. The intensity of the
emitted radiation is determined by a suitable
spectrometer and compared to the standard:
A. Atomic absorption spectroscopy
B. Supercritical fluid extraction
C. Flame photometry
D. Tandem mass spectrometry
E. Refractometry
Answer: C. Flame photometry
129. A self-indicating volumetric solution:
A. Iodine VS
B. Ceric sulfate VS
C. Potassium permanganate VS
D. Ammonium thiocyanate VS
E. sodium hydroxide VS
Answer: C. Potassium permanganate VS
130. Alkalimetric assay which involves a
preliminary oxidation step via oxygen flask
combustion prior to titration.
A. Ethyl acetate
B. Formaldehyde solution
C. Zinc undecylenate
D. Precipitated sulfur
E. Sodium metabisulfite
Answer: D. Precipitated sulfur
131. Preferred titrant for the analysis of ferrous
salts in mixtures that contain excipient or
diluents that have a reducing action on
permanganate:
A. Silver nitrate VS
B. Ceric sulfate VS
C. Sodium thiosulfate VS
D. Disodium EDTA VS
E. Hydrochloric acid VS
Answer: B. Ceric sulfate VS
132. Oxidizing agents are assayed titrimetrically
by:
A. Acidimetry D. Iodometry
B. Cerimetry E. Iodimetry
C. Miscellaneous redox
Answer: D. Iodometry
133. The law which relates the power of the
incident and transmitted beams to the thickness
and concentration of solution containing the
absorbing chemical species:
A. Beer-Lambert’s law D. Snell’s law
B. fick’s law E. hess’ law
C. Nernst’s law
Answer: A. Beer-Lambert’s law
134. Calibration weights that are used as
working standards for calibration, built-in
weights for analytical balances, and laboratory
weights for routine analytical work:
A. Class P or class 4
B. Class s-1 or class 3
C. Class S or class 2
D. class M or class 1
E. none of the choices
Answer: C. Class S or class 2
Revision. CD-ROM
135. A substance of known purity that is used
for deyermination of the exact soncentration of
a volumetric solution:
A. Analyte D. Primary standard
B. Blak determination E. Titer value
C. Equivalence factor
Answer: D. Primary standard
136. The eye should be at same level as the
meniscus to prevent ______:
A. Color blindness D. Calibration error
B. Number bias E. Capillary action
C. Parallax error
Answer: C. Parallax error
137. Extemporaneously compounded 10%
potassium chloride should be used within
_______ when stored at cold temperatures:
A. 7days D. 60days
B. 14days E. 120days
C. 30days
Answer: B. 14days
138. Assay which employs the use of a jones
redactor:
A. Alkaloid content of opium
B. Cherry juice for malic acid
C. Titanium dioxide
D. Selenium sulfide
E. Dimercaprol
Answer: C. Titanium dioxide
139. Kjeldahl method:
A. Water content deretmination
B. Nitrogen content determination
C. Oxygen flask combustion
D. Nonaqueous titration
E. Specific gravity determination
Answer: B. Nitrogen content determination
Revision. CD-ROM
140. The following tests cannot be done by
ignition:
A. Moisture content determination
B. Ash content determination
C Extractives
D. A and B
E. A, B and C
Answer: C Extractives
Revision. CD-ROM
141. In method II of water content
determination, the sample should yield about
_____ mL of water for accurate readings:
A. 5-8mL D. 1-3mL
B. 3-6mL E. None of the choices
C. 2-4mL
Answer: C. 2-4mL
142. Glassware employed in method II of water
content determination in USP:
A. Soxhlet apparatus
B. Toluene moisture apparatus
C. Clavenger apparatus
D. Babcock bottle
E. Reflux condenser
Answer: B. Toluene moisture apparatus
143. Azeotropic distillation is utilized in the USP
for determination of ______ of pharmaceutical
articles:
A. Alcohol content D. Water content
B. Aflatoxins E. Steroid content
C. Bacterial endotoxins
Answer: A. Alcohol content
Revision. CD-ROM
144. Calculate for Rf value given the following
data: Distance travelled by solvent=8.7cm
Distance travelled by solute=3.2cm
A. 0.37 D. 0.63
B. 2.72 E. 5.95
C. 27.84
Answer: A. 0.37
145. Powder flow testing:
A. Angle of repose D. Shear cell
B. Compressibility index E. All of the choices
C. Hausner ratio
United States Pharmacopeial Convention,Inc.The
United States Pharmacopeia 30th edition and The
National Formulary 25th Revision. CD-ROM
146. Total alkalinity of sodium hydroxideis due
to what chemical species?
A. Carbonate ion D. A and B
B. hydroxide ion E. A, B and C
C. Phosphate ion
Answer: D. A and B
147. For stability testing purposes, the
Philippines is categorized in what climatic zone:
A. I D. IV
B. II E. V
C. III
Answer: D. IV
Revision. CD-ROM
148. Calcium pantothenate assay employs what
method?
A. Refractometry D. NMR
B. TUrbidimetry E. Potentiometric
C. HPLC
Answer: B. Turbidimetry
Revision. CD-ROM
149.Buffer solution:
A. Arrhenius Equation
B. Clausius-Clapeyron equation
C. Henderson-Hasselbalch equation
D. Nernst equation
E. Whitney-Noyes equation
Answer: C. Henderson-Hasselbalch equation
150. In pharmaceutical assaying, the official
requirement of diluted acids is expressed on __
basis.
A. Molarity
B.Percent weight in weight
C.Percent weight in volume
D. Percent volume in volume
E.Normality
Answer: C. Percent weight in volume
151. Titanium Dioxide is assayed by what
method?
A. Alkalimetry D. Gravimetry
B. Iodometry E. Volumetric pricipitation
C. Permanganometry
Answer: C. Permanganometry
152. Equivalence factor for assay of Pjosphoric
Acod, NF:
A. 1 D. 4
B. 2 E. 10
C. 3
Answer: B. 2
153. Calibration of burets may be done using_:
A.Kiehl buret
B.Mohr buret
C.Ostwals calibrating pipet
D.A and C
E.A and B
Answer: D. A and C
Answer: B. 2
154. Given the following log Kf values for the
following metal ion-EDTA complexes, which of the
following cannot be titrated successfully with EDTA?
I. Ba-EDTA-2 = 7.76
II. Co-EDTA-2 = 16.39
III. V-EDTA = 25.9
IV. Sr-EDTA-2 = 8.63
A.II and III D. III only
B.I and IV e. I, II, III AND IV
C.I only
Answer: C.I only
155. Sodium tetraphenylboron will quantitavely
precipitate:
I. Alkaloids
II. Quaternary salts
III. Silver ions
A.I only D. I,II and III
B.I and II E. I and III
C.II and III
Answer: D. I,II and III
156. An excellent solvent for fats and fatty oils
used in the determination of extractive content
of a plant sample:
A. alcohol D. Hexane
B. Diluted alcohol E. water
C. Ether
Answer: D. Hexane
157. Temperature equivalent of dull-red heat:
A. 500-550oC D. 1000-1200oC
B. 550-700oC E. 1200-1600oC
C. 800-1000C
Answer: B. 550-700oC
158. Represent the inorganic salts naturally
occurring in the drug and adhering to it, but may
also include inorganic matter added for the
purpose of adulteration.
A. Ash content D. Water content
B. Crude fiber E. Unsaponifiable matter
C. Loss on ignition
Answer: A. Ash content
159. Vitamin b12 activity assay employs what
method of analysis?
A. fluorimetry D. Turbidimetry
B. HPLC E. Reverse osmosis
C. Colorimetry
Answer: D. Turbidimetry
Revision. CD-ROM
160. Official methods of demonstrating
antimicrobial activity:
A. Turbidimetric assay D. A an C
B. Brine shrimp assay E. B and C
C. Cylinder-plate assay
Answer: D. A an C
Revision. CD-ROM
161. Cultute media of fungi:
A. V5 agar
B. Eosin- Methylene blue media
C. Thioglycollate media
D. Saboraud’s dextrose media
E. Soy-bean- casein digest media
Answer: D. Saboraud’s dextrose media
Revision. CD-ROM
162. Plane polarized light is produced by what
type of optical lens?
A. Echelette grating D. LASER
B. Iceland spar E. Concave lens
C. Oil immersion objective
Answer: B. Iceland spar
163. Assayeed by double titration:
A. Sodium hydroxide
B. Sodium nitrite
C. Dibasic sodium phosphate
D. Sodium bromide
E. Calcium Disodium Edetate
Answer: B. Sodium nitrite
164. Which of the following volumetric solution
should be read using upper meniscus?
A. Ceric sulphate
B. Ferrous ammonia sulfate VS
C. HCl VS
D. Potassium permanganate VS
E. Sodium nitrite VS
Aswer: D. Potassium permanganate
VSKnevel,A.M. and F.E. DiGangi.1997.Jenkins
165.EDTA titration of calcium salts requires a pH
of __ to ensure to complete reaction.
A. 2 D. 14
B. 4.6 E. None of the choices
C. 13
Answer: C. 13
166. Determine the %w/w of alakaloids present in the
belladonna leaf ( calculated as atropine) if 15 ml of
0.0210 N sulfuric acid was added to the extracted
alkaloids and 7.30 ml of 0.0198 N sodium hydroxide was
required for the residual titration. The weight of the
powder of Belladona leaf was 10.21 g. in that reaction, 2
moles of atropine consume 1 mole of sulfuric acid during
titration. (MW of atropine= 239.8 g/mol).
A. 0.966% D. 96.60%
B.0.483% E. 24.20%
C. 0.242%
Answer: B.0.483%
167. An acetylization flask is used in the
determination of:
A. Total ester content of peppermint oil
B. Total menthol content of peppermint oil
C. Carvone content of caraway oil
D. Benzaldehyde
E. Clove oil
Answer: B. Total menthol content of peppermint
oil
168. If a 1.2500 g sample of Zinc oxide, 95.0%
ZnO, were treated with 50.00% ml of 1.1230 N
sulphuric acid in the casual way, what volume of
0.9765 N sodium hydroxide would be required
in the back titration? (MW of ZnO= 81.38
g/mol).
A. 42.54 mL D. 2.27 mL
B. 27.48 mL E. 0.00mL
C. 12.47 mL
Answer: B. 27.48 mL
169. Starch TS is a satisfactory indicator for what
volumetric solution?
A. HCl VS D. Sodium Thiosulfate VS
B. Potassium Iodate VS E. Silver nitrate VS
C. Cerric sulfate VS
Aswer: D. Sodium Thiosulfate VS
170. A type of redox reaction that leads to n
increase in positive valence of a chemical
species:
A. Oxidation D. Combustion
C. Reduction E. Displacement
E. Decomposition
Answer: A. Oxidation
171. A specific gravity bottle that has a
thermometer stopper and a capillary overflow
tube:
A. Geissler pycnometer D. Lovi’s beads
B. Pycnometer E. Saccharometer
C. hygrometer
Answer: A. Geissler pycnometer
172. A nicol prism is an intergral part of what
instrument?
A. Refractometer D. IR spectrometer
B. Polarimeter E. Analytic balance
C. HPLC
Answer: B. Polarimeter
173. Failure to judge color change sharply during
titration can lead to what type of error?
A. Interminate error D. Personal error
B. Instrumental error e. Number bias
C. Methodic error
Answer: D. Personal error
174. Given the ff. Ksp values for the ff. sulfides, rank
the ff. insoluble sulfides according to increase
solubitliy:
MnS= 3.0 x 10 -14
CdS= 8.0 x 10-28
Cos = 4.0 x 10-21
A. CdS>Cos> Mns D. CoS< CdS < MnS
B. CdS<Cos< Mns E. None of the choices
C. CdS>MnS>CoS
Answer: A. CdS>Cos> Mns
175. Suitable precipitate for the determination
of mercury content by gravimetric analysis:
A. Sodium Sulfate TS D. Magnesia Mixture
B. Ammonia TS E. Barium Chloride
C. Hydrogen Sulfide
Answer: C. Hydrogen Sulfide
176. Sulfated potash is assayed gravimetrically
by converting it to __, which is then weighed.
A. Barium sulfate
B. Magnesium ammonium phosphate
C. Zinc oxide
D. Cupric oxide
E. Potassium bipthalate
Answer: D. Cupric oxide
177. Appropriate laboratory apparatus for
carrying out ignition:
A. Oven D. Fume hood
B. Electric furnace E. Hot plate
C. Biosafety cabinet
Answer: B. Electric furnace
178. Appropriate solvent for resins for
extraction purposes;
A. Ether D. Ethanol
B. Water E. Petroleum Ether
C. Hexane
Answer: D. Ethanol
179. Residue consisting chiefly of cellulose that
remains undissolved after successive treatment
with boiling acid and alkali:
A. Total ash D. Unsaponifiable Matter
B. Crude Fiber E. Looss on Drying
C. Sulfated Ash
Answer: B. Crude Fiber
180. A solution that contains methanol, iodine.
Sulphur dioxide, and pyridine:
A. Wij’s rgt. D. Koppeschaar’s Solution
B. Mayer’s rgt. E. Deniges’ rgt.
C.Karl fischer rgt.
Answer: C.Karl fischer rgt.
181. Standard solution that is most susceptible t
air oxidation?
A. Ferrous ammonium sulphate TS
B. Oxalic Acid VS
C. Sodium thoisufate VS
D. Titanium trichloride
E. Potassium arsenite
Answer: D. Titanium trichloride
182. Addition of an excess titrant to permit
complete reaction of the analyte with the titrant
and then the unreacted excess titrant with
another standard soulution:
A. Blank determination D. Residual
titration
B. Direct titration E. Displacement
titration
C. Double titration
Answer: D. Residual titration
183. In the assay of Rochelle’s salt, the
compound formed after ignition prior to
titration is:
A. Carbonate D. Carbon
B. Oxide E. Tartaric Acid
C. Bicarbonate and carbonate
Answer: A. Carbonate
184. primary interference present during
alkalimetric titration:
A. Carbonate D. Saliva
B. Metal ions E. Halides
C. Organic matter
Answer: A. Carbonate
185.The weight of a substance chemically
equivalent to 1mL of a standard solution:
A. Equivalent weight D. Mole
B. Titer E. Calibration
standard
E. Molecular weight
Answer: B. Titer
186. Acid titrant preferred for hot titrations:
A. Percholic acid VS D. Acetic acid VS
B. HCl VS E. Nitric acid VS
C. Sulphuric scid VS
Answer: C. Sulphuric scid VS
187. Purpose of chloroform in the assay of
Phenol. USp:
A. Serves as extracting indicator for liberated
iodine during titration
B. To act as co-solvent for the analyte
C. To dissolve tribomophenol for clesar
observation of endpoint
D. all of the choices
Answer: C. To dissolve tribomophenol for clesar
observation of endpoint
188. In iodometric titration, what should be the
color be the color of the solution prior to the
addition of Stratch TS?
A. Intense brown D. Colorless
B. Amber E. Intense blue
E. Green
Answer: B. Amber
189. How many gram-atom of iodine is liberated
by one of sodium hypochlorite in the assay of
sodium hypochlorite solution?
A. 1 D.10
B. 2 E.46
C. 4
Answer: B. 2
190. Type of reaction that is involved for
compounding such as aniline and resorcinol;
assayed by bromination:
A. Rearrangement D. Free radical formation
B. Substitution E. Condensation
C. Elimination
Answer: B. Substitution
191. A volumetric Solution that is prepared from
a very pure substance and hence do not require
standardization step:
A. Iodine VS
B. Silver Nitrate VS
C. Potassium Iodate VS
D. Dichlorophenol-Iodophenol VS
E. Bromine VS
Answer: C. Potassium Iodate VS
192. In ash content determination, incomplete
combustion leads to formation of:
A. Carbon dioxide D. Carbonyl
B. Carbon E. Carbide
C. Carbonate ion
Answer: B. Carbon
193. Fat constant that aids in the detection of
the presence of glyceridesof acides containing
less than 16 or more that 18 carbon atoms:
A. Acid value
B. Saponification value
C. Ester value
D. Reichert-Messl number
E. Polenske value
Answer: B. Saponification value
194. In the assay of peppermint oil for total ester,
the blank determination serves to:
A. Account for an absorption if CO2 by the base
B. Corrects any alkalinity arising from interaction of
the analyte solution with the glass
C. Accounts for air-oxidation of analyte which might
have occurred
D. A and B
E. A, B and C
Answer: D. A and B
195.Reagent that provides a blanket of inert
atmosphere during iodometric determination:
A. HCl D. Strach TS
B. Sodium bicarbonate E. KI
C. Sodium carbonate
Answer: B. Sodium bicarbonate
196. Suitable backtitrant for titration involving
the use of excess silver nitrate VS:
A. Ammonium thiosulfate VS
B. Sodium tetraphenylboron VS
C. Lithium methoxide VS
D. Potassium Ferrocyanide VS
E. Ceric Sulfate VS
Answer: A. Ammonium thiosulfate VS
197. Complementary color of yellow:
A. Red D. Yellow-green
B. Purple E. Blue-green
C. Blue
Answer: C. Blue
198. Energy of a molecule that is NOT involve in
spectroscopic studies:
A. electronic D. translational
B.vibrational E. A and B
C. rotational
Answer: D. translational
199. Suitable method of separating highly
volatile compounds:
A. Chiral chromatography
B. Supercritical fluid chromatography
C. Gas chromatohraphy
D. Medium pressure liquid chromatography
E. Medium pressure liquid chromatography
Answer: C. Gas chromatohraphy
200. In the equation HF + H2O H30 + F-:
A. H2O is a base, and HF is its conjugated acid.
B. H2O is an acid, and HF is the conjugated base.
C. HF is an acid and F is its conjugated base.
D. HF is a base and H3O is its conjugated acid.
E. HF is a base. And F is its conjugated acid.
Answert: C. HF is an acid and F is its conjugated
base.
201. This type of airflow has a varying velocity
and is usually for Class 1000 and 10000,
A. Laminar fairflow D. Down flow
B. Unidirectional airflow E. Up flow
C. Non-uniderectional airflow
Answer: C. Non-uniderectional airflow
PDHonline, A Basic Design Guide For Cleanroom
Applications,2011,14
202. It is a property of liquids that is closely
related to resistance to flow
A. Surface tension D. Temperature
B. Rheology E. Melting Range
C. Viscosity
Answer: C. Viscosity
US Pharmacopeial Convention Inc,USP 34/NF
29,2010, 406
203. In the absolute scale, viscosity is measured
in the poise of centipose. In the kinematic scale,
it is measured in the __.
A. Poise D. Newton
B. Contipoise E. Milinewton
C. Stokes
Answer: C. Stokes
29,2010, 406
204. This test determines the resistance to
water attack of new glasses containers EXCEPT:
A. Powdered glass test
B. Surface attack test
C.Water attack test
D. Acidimetry E.
NOTA
Answer: D. Acidimetry
29,2010, 255
205. it is an indirect measure if inorganic
molecules present in pharmaceutical waters
measured as carbon.
A. Total inorganic Carbon D. Choices B and C
B. Total organic carbon E. NOTA
C. Organic Carbon
Answer: B. Total organic carbon
29,2010, 251
206. this date limits the time during whick the
product may be dispensed or used.
A. Manufacturing date D. Choices B and C
B. Exiration date E. NOTA
C Use date
Answer: B. Exiration date
29,2010, 286
207. It is a measure of propensity of a powder to
be compresed:
A. Bulk density D. Carr’s index
B. Tapped Density E. AOTA
C. angle of repose
Answer: D. Carr’s index
29,2010, 4671
208.Weight Variation method can be applkied
to the ff. dosage forms EXCEPT:
A. Liquid filled soft capsule
B. Transdermal system
C. Singe unit for inhalation
D. Sterile solid with no added active substance
E. Hard gelatin capsule
Answer: B. Transdermal system
29,2010, 403
209. Initially, how many samples are required
for minimum fil?
A. 10 D. 30
B. 15 E. AOTA
C. 20
Answer: A. 10
29,2010, 311
210. The ff. are official tests employed in
semisolid dosage forms, EXCEPT:
A. viscosity . D.Particle size distribution
estimation
B. pH E. AOTA
C. spreadability
Answer: C. spreadability
29,2010.
211. It is designed to limit to a level considered
to be objectionable the number and size of
discrete metal particles that may occur in
ophthalmic ointments.
A. particle size distribution D. deliverable
volume
B. metal particles E. NOTA
C. minimum fill
Answer: B. metal particles
29,2010, 311
212. the consistency values of semisolid form
can be determined using a:
A. viscometer D. mechanical tap density
tester
B. Spatula E. Rheometer
C. penetrometer
Answer: C. Penetrometer
29,2010, 3883
213. Minimum fill is applicable to any of the ff.,
EXCEPT:
A. container with a labeled amount of 60g or less
B.Container with a labeled amount of 150g or less
C. container with a labeled amount of 150g
D. container with a labeled amount of more than
150g
E. NOTA
Answer: D. container with a labeled amount of
more than 150g
29,2010, 311
214. Minimum fill can be applied to such
articles, EXCEPT:
A. creams D. lotion
B. gels E. NOTA
C.jellies
Answer: E. NOTA
29,2010, 311
215. Color comparison tubes are used for what
official C?
A. Limit test for chlorides
B. color comparison test
C. test for readily carbonizable substance
D. limit test for sulfates
E. NOTA
Answer: C. test for readily carbonizable
substance
29,2010, 251
216. All of the ff. are used as colorimetric
standars, except:
A. Ferric chloride CS D. Calcium Chloride CS
B. Cupric sulfate CS E. NOTA
C. Cobaltous chloride CS
Answer: D. Calcium Chloride CS
29,2010, 4807
217. This Raw Material Quality Control test
entails addition if silver nitrate to a HCl acid
standard.
A. Limit test for Chloride
B. limit test for sulfates
C. limit test for sulfides
D. litim test for chlorates
E. limit test for acetates
Answer: A. Limit test for Chloride
29,2010, 1931
218.This Raw Material Quality Control test
entails addition of barium chloride to a sulfuric
acid __ standard.
Answer: B. limit test for sulfates
29,2010, 1931
219.This Raw Material Quality Control test
entails the use if lead acetate paper:
Answer: C. limit test for sulfides
29,2010, 1720
220. This official ID test entails comparison of
retention factor.
A.Thin layer chromatography
B.UV
C. IR
D.GC
E. NMR
Answer: A.Thin layer chromatography
29,2010, 244
221.Measurement where the sample is diverted
from the manufacturing process, and maybe
returned to the process stream.
A. At-line D. Off-line
B. On-line E. NOTA
C. In-line
Answer: B. On-line
US Department of Health and Human Services,
Guidance for Industry: A framework for
innovative Pharmaceutical Development,
Manufacturing, and Quality Assurance,20049
222. which of the ff. is an official ID test for
Aspirin
A. limit of free p-aminophenol
B. limit of free salicylic acid
C. FECl3 test
D. limit for magnesium
E. NOTA
Answer: C. FECl3 test
29,2010, 1931
223. Method II of water determination involves
A. tartration D. stoichiometry
B.Azeotropic distillation E. NOTA
C.Gravimetry
Answer: B.Azeotropic distillation
29,2010, 4677
224. In HPLC analysis, the official measure of
column efficiency is
A. Retention time D. width
B. tailing factor E. AOTA
C. number of theoretical plates
Answer: C. number of theoretical plates
29,2010, 246
225. The official measure of peak symmetry in
HPLC is:
A. retention time D. width
B.Tailing factor E. AOTA
Answer: B.Tailing factor
29,2010, 248
226. Which of the ff. is used to identify peaks in
the chromatogram?
A. Retention time D. width
B. tailing factor E. AOTA
Answer: A. Retention time
29,2010, 247
227. The test od weight variation is applicable
for the ff. dosage forms, EXCEPT:
A. Uncoated tablets D. Solution in soft capsule
B. Film-coated tablets E.Enteric-coated tablets
C.Suppositories
Answer: C.Suppositories
29,2010, 406
228. The test for conformity is required for the
ff. dosage forms EXCEPT:
A. Suppositories D. Solutions in soft capsules
B. Transdermal system E. NOTA
C. Suspension
229.Passage of fluid or solution through a
sterilizing grade membrane to produce a sterile
effluent
A.Terminal sterilization
B.Sterilization by filtration
C.Aseptic processing
D.Disinfection
E.NOTA
Answer: B. Sterilization by filtration
United States Pharmacopeial Convention
Inc,USP 34/NF 29,2010,339
Answer: D. Solutions in soft
29,2010, 403
230. The performance variationtest is performed
in dissolution apparatus 1 and 2 using
A.USP Aspirin Tablet RS
B. USP Salicilic acid RS
C. USP Prednisone Tablet RS
D. USP Chlorpheneramine Maleate Extended
Release Tablets RS
E. AOTA
Answer: C. USP Prednisone Tablet RS
29,2010, 280
231. The performance variation test is performed in
dissolution apparatus 1 and 2 using
A.USP Aspirin Tablet RS
B. USP Salicilic acid RS
C. USP Prednisone Tablet RS
D. USP Chlorpheneramine Maleate Extended
Release Tablets RS
E. AOTA
Answer: D. USP Chlorpheneramine Maleate
Extended Release Tablets RS
29,2010, 280
232. Official temperature for determination of
specific gravity
A. 10oC D. 30oc
B.20 oc E.35oc
C.25oc
Answer: C.25oc
29,2010, 389
233. Powders with an angle of repose
equivalent to 30o is said to have
A. Excellent flow property D.Poor flow
property
B. Good flow property E. Very poor flow
property
C. Fair flow property
Answer: A. Excellent flow property
29,2010, 724
234. Powders with compressibility index of 18%
and has a hausner’s ratio of 1:20 has a/an
A. Passable flow character
B. Fair flow character
C. Good flow character
D. Excellent Flow character
E. NOTA
Answer: B. Fair flow character
29,2010, 725
235. The test limit for powdered glass test of
highly resistant, borosilicate glass is
A. 5.0mL D. 1.5mL
B. 8.5mL E.1.8mL
C. 1.0mL
Answer: C. 1.0mL
29,2010, 257
236. The critical test parameter for each
dissolution apparatus is true, except:
A. Apparatus 1-Rotation speed
B. Apparatus 2- Rotation speed
C. Apparatus 3-Dip rate
D. Apparatus 4- Flow rate of medium
E. NOTA
Answer: E. NOTA
29,2010, 280
237. The test limit for powdered glass test of
general purpose glass is
A. 1.0mL D. 15mL
B . 8.5mL E. 18mL
D.10mL
Answer: D.10mL
29,2010, 257
238. This is a purified water that has been boiled
vigorously for 5 min. or more and allowed to
cool while protected from absorption for carbon
dioxide from the atmosphere
A. Distilled water D.Carbon-dioxide free
water
B.Deionized water E. Nitrogen-free water
C.UV treated water
Answer: D.Carbon-dioxide free water
29,2010, 256
239. For measurement of viscosity, the
temperature of the substance should be held to
within
A.+0.1 D. +0.4
B. + 0.2 E. +0.5
C. 0.3+
Answer: A.+0.1
29,2010, 407
240.The following dissolution apparatus can be
used for the drug release requirement of
transdermal delivery system except:
A. Apparatus 4 D. Apparatus 7
B. Apparatus 5 E. Apparatus 8
C. Apparatus 6
Answer: A. Apparatus 4
29,2010, 283
241. Reciprocating cylinder is also known as:
A. Apparatus 1 D. Apparatus 4
B. Apparatus 2 E. Apparatus 5
C. Apparatus 3
Answer: C. Apparatus 3
29,2010, 278
242. The ff. are dissolution media employed in
the comparative dissolution profile testing for
bioequivalence, except:
A. pH 1.2 buffer D. pH 7.5 buffer
B. pH 4.5 buffer E. NOTA
C. pH 6.8 buffer
Answer: D. pH 7.5 buffer
29,2010, 622
243. Method I of measuring bulk density
A. Measurement in a graduated cylinder
B. Measurement in a volumeter
C. Measurement in a tachometer
D. Measurement in a manometer
E. Measurement in a rheometer
Answer: A. Measurement in a graduated
cylinder
29,2010, 4670
244. Method II of measuring bulk density
A. Measurement in a graduated cylinder
B. Measurement in a volumeter
C. Measurement in a tachometer
D. Measurement in a manometer
E. Measurement in a rheometer
Answer: B. Measurement in a volumeter
29,2010, 4670
245. A carr’s index of 27 implies a/an
A. Excellent flow D. Poor flow
B. GOOD flow E. Very poor flow
C. Passable flow
Answer: D. Poor flow
29,2010, 725
246 Dissolution testing should be conducted at
this temperature
A. 37+0.5oC D. 37+2oC
B. 37+2oC E. 37+0.1oC
C. 37+0.2oC
Answer: A. 37+0.5oC
29,2010, 278
247. Disintegration testing should be conducted
at this temperature
A 37+0.5oC D. 37+2oC
B. 37+2oC E. 37+0.1oC
C. 37+0.2oC
Answer: B. 37+2oC
29,2010, 276
248. delayed release tablet can also be called
A.Enteric coated tablet D. SGF
resistant tab
B. Avid resistant tablet E. 0.1N HCl
resistant
C. SIF resistant tablet
Answer: A.Enteric coated tablet
29,2010, 276
249. Buccal tablet should disintegrate within
A. 1hr D. 4hr
B. 2hr E. 5hr
C. 3hr
Answer: D. 4hr
29,2010, 277
250. It is a test to detect or quantify endotoxin
from Gram negative bacteria using amoebocyte
lysate from horshoe crab.
A.Leaker’s test
B.Bacterial endotoxin test
C.Light transmission test
D.Surface contamination test
E.Flow through test
Answer:
Bacterial endotoxin test
29,2010, 78
251. Kb is the equation of colligative property is
AKA?
A.Cryoscropic constant
B.Dissociation constant
C.Ebbuliooscopic constant
D. Freezing point constant
E. nota
251. The three technique for the bacterial
endotoxin test are the ff.except
A.Gel clot
B.Turbidimetric
C.Allosteric
D.Chromogenic
E.NOTA
Answer: C.Allosteric
29,2010, 78
252. This test determines whether the dose in a
batch of units is uniform and it the dosage form
can deliver the right amount of dose in each
patient
A. Weight variation D. Hardness
B. Assay E. Disintegration
C. Moist content
Answer: A. Weight variation
29,2010, 403
253. This test stimulus the physiological
conditions of the body and can therefore predict
bioavailability as this prerequisite of absorption.
C. Moist content
Answer: A. Weight variation
29,2010, 276
255. This test shows how well a resists chipping
ang crumbling when external stresses are
applied.
C. Moist content
Answer: D. Hardness
29,2010, 770
256. This test shows how well a resists chipping
ang crumbling when external stresses are
applied.
E. Moist content
Answer: E. Disintegration
29,2010, 770
257. This hardness tester is based on
compressing tablets between two jaws via a
spring gauge and screw
A. Erweka D. Strong-Cobb
B. Monsanto E. Varian
E. Pfizer
Answer: B. Monsanto
29,2010, 770
258. Powder fineness can be blassified using this
method.
A. Optical Microscopy D. Sedimentation
B. Analytical Seiving E. Strokes
C. Moisture content
Answer: B. Analytical Seiving
29,2010, 377
259. The ff. shoud be strictly avoided when
using analytical sieves, except:
A. Oven drying
B. Cleaning using liquid stream
C. Removal of blockade by brushing
D. Rinsing with nitric acid
E. Choices C and D
Answer: E. Choices C and D
29,2010, 324
260. The following are methods of sieving,
EXCEPT:
A. Mechanical method- Dry sieving
B. Air Entrapment method-Air jet sieving
C. Air Entrapment method- sonic sifter sieving
D. AOTA
E. NOTA
Answer: E. NOTA
29,2010, 325
261. Method 1 in determining particulate matter
in injection involves:
A. Light obscuration particle count test
B. Sedimentation Test
C. Microscopic particle count test
D. minimum fill
E. Melting range
Answer: C. Microscopic particle count test
29,2010, 326
262. This test determines the consistency of
dosage units and if each unit in a batch has a
drug substance within a narrow range around
the label claim.
A. Content uniformity D. Solubility
B. Weight variation E. Minimum fill
C. Spreadability
Answer: E. Minimum fill
US Pharmacopeial Convention Inc,USP
34/NF 29,2010, 311
263. This test will determine whether a
suspension will not settle out rapidly in the
container, will become fluid on shaking, and will
remain so long enough for a dose to be
dispensed:
A. Sedimentation volume D. Minimum fill
B. Viscosity E. Assay
C. Deliverable volume
Answer: B. Viscosity
Lachman, L HA liebermann and JL Kanig, The
Theory and Practice of Industrial Pharmacy,1976
2nd ed.554
264. This test provides assurance that oral
liquids will, when transferred from the original
container, deliver the volume of dosage form
that is declared on the label of the article:
Answer: C. Deliverable volume
29,2010, 272
265. This test classifies whether the suspension
is flocculated or deflocculated one:
Answer: A. Sedimentation volume
Osol Arthur, Remington’s Pharmaceutical
Sciences, 1980 16th ed,308
266. Method 1 of determining particulate
matter in injections cannot be applied to,
EXCEPT:
A. Emulsions D. Solutions
B. Colloids E. NOTA
C. Liposomes
Answer: D. Solutions
29,2010, 326
267. This method of determining particulate
matter in injections utilizes a binocular
microscope:
A. Method 1 D. Method 4
B. Method 2 E. NOTA
C. Method 3
Answer: B. Method 2
29,2010, 327
268. An analyst performed powdered glass test.
The volume of 0.02N H2SO4 consumed for trials 1
and 2 were found to be 0.70mL and 0.75mL,
respectively, and corrected for a blank. The general
description of the container should be:
A. Highly resistant, borosilicate glass
B. Treated soda-lime glass
C. soda lime glass
D. General- purpose soda-lime glass
E. NOTA
Answer: B. Treated soda-lime glass
29,2010, 257
269. Example/s of product/s where containers
of type 1 glass are generally used:
A. Oral suspensions
B. Hair cream
C Dextrose 5% in water
D. Salicylic acid ointment
E. AOTA
Answer: C. Dextrose 5% in water
29,2010, 256
270. 6 ampoules were filled with medium up to
height of the shoulder and the volumes were
found to be in 8.21mL, 8.24mL, 8.21mL, 8.25mL,
8.23mL and 8.25mL. The filling volume for the
particular ampoule lot is:
A. 8.1mL D. 8.4mL
B. 8.2mL E. 8.5mL
C. 8.3mL
Answer: B. 8.2mL
29,2010, 257
271. Based on the previous problem, the
volume(mL) of the test liquid necessary for one
titration should be:
A. 25.0 D. 125
B. 50.0 E. 130
C. 100
Answer: B. 50.0
29,2010, 257
272. Referring to item # 70, the extraction
solutions are analyzed by titration. How many
trials are required?
A. 2 D. 5
B. 3 E. 6
C. 4
Answer: A. 2
29,2010, 257
273. The volume(mL) of 0.02N H2SO4 for treated
soda lime glass with a volume of 80mL should
not exceed:
A. 0.2 D. 1.0
B. 0.7 E. 1.2
C. 0.9
Answer: B. 0.7
29,2010, 258
274. the filing volume is the volume to be filled
with _____ in the container for the purpose of
the test:
A. Purified water D. 0.02N NaOH
B. water for injection E. NOTA
C. 0.02N H2SO4
Answer: A. Purified water
29,2010, 257
275. Sterile filling facilities are usually:
A. Class100 D. Class100000
B. Class1000 E. Class1000000
C. Class10000
Answer: A. Class100
29,2010
276. For ampoules the filling volume is the
volume up to the height of the ____:
A. Neck D. Vent
B. Shoulder E. NOTA
C. Tip
Answer: B. Shoulder
29,2010, 276
277. A glass container intended to provide
protection form light should meet requirement
of what test?
A. light transmission test
B. Arsenic test
C. Light deflection test
D. light absorption/ionization test
E. Absorption
Answer: A. light transmission test
29,2010
278. Sublingual tablets must disintegrate within:
A. 30mins D. 4hours
B. 60mins E. As specified in the
monograph
C. 1hour
Answer: E. As specified in the monograph
29,2010, 277
279. This refers to the ratio of the mass of an
untapped powder sample and its volume
including the contribution of the interparticulate
void volume:
A. Bulk density D. Hausner’s ratio
B. Tapped density E. NOTA
C. Angle of response
Answer: A. Bulk density
29,2010, 4670
280. This method of determining the type of
emulsion utilizes the knowledge that a water
soluble dye will dissolve in the aqueous phase of
an emulsion while an oil-soluble dye will taken
up by the oil phase:
A. Dilution Test D. B and C
B. Conductivity test E. NOTA
C. Dye-solubility test
Answer: C. Dye-solubility test
Osol Arthur, Remington’s Pharmaceutical
Sciences, 1980 16th ed,311
281. This test is designed to limit to a level
considered to be unobjectionable the number
and size of discrete metal particles that may
occur in ophthalmic ointments:
A. Sterility
B. Metal particles in ophthalmic ointment
C. Microbial count
D. pH
E. Arsenic release
Answer: B. Metal particles in ophthalmic
ointment
29,2010, 311
282. This test is an indication of crystal habit,
presence of polymorphic form etc.:
A. Optical microscopy
B. particle size distribution estimation
C. viscosity
D. Minimum fill
E. Deliverable volume
Answer: A. Optical microscopy
29,2010, 318
283. This test is intended is to determine the
temperature at which the semisolid melts and
therefore indicates proper storage and
application:
A. Loss on drying D. thickness
B. Melting range E. Friability
C. solubility
Answer: B. Melting range
29,2010, 276
284. What is/are the required immersion fluid/s
for coated tablets?
A. water
B. simulated gastric fluid
C. simulated intestinal fluid
D. A and B
E. B and C
column.
Answer: D. A and B
29,2010, 276
285. This test stimulates the flow of a bed of
powder or granules in a hopper:
A bulk density D. Carr’s index
B. tapped density E. Hausner’s ratio
C. angle response
Answer: C. angle response
29,2010, 724
286. Efficiency of separation could be increased
with:
A. Increase in plate height
B. Decrease in plate height
C. decrease in plate count
D. Decrease in pressure
E. increasing in tailing
Answer: B. Decrease in plate height
29,2010, 246
287. This test is intended for type 1 containers
for aqueous parenteral preparation:
A. powedered glass test D. surface glass test
B. arsenic release E. NOTA
C. water attack test
Answer: B. arsenic release
29,2010, 258
288. Explosives can be identified by what color
of placards?
A. red D. yellow
B. orange E. blue
C. green
Answer: B. orange
USP Department of Transportation, Emergency
Response Guidebook,2006,16
289. Oxidizers and organi peroxides fall under
class:
A. class5 D. class8
B. class6 E. class9
C. class7
Answer: A. class5
USP Department of Transportation, Emergency
Response Guidebook,2006,14
290. it refers to the time a certain constituents
passes through the HPLC
A. Retardation factor D. Retention Time
B. Retardation time E. NOTA
C. Retardation factor
Answer: D. Retention Time
29,2010, 243
291. These are the four basic mechanisms in
which fibrous air filter remove contamination
from airstreams:
A. sieving D. Diffusion
B. impaction E. AOTA
C. interception
Answer: E. AOTA
PDHonline, A Basic Design Guide for Cleanroom
Applications,2011,9
292. This refers to the contamination of a
starting material, intermediate product, or
finished product with another starting material
or product during manufacture.
A. mixed-ups D. Scale up
B. cross contamination E. AOTA
C. Sanitation
Answer: B. cross contamination
293. This is the heart of a clean room:
A. Barometer D. HEPA filter
B. HPLC E. Laminar flow wood
C. oven
Answer: D. HEPA filter
294. This is a room or area where the product is
formulated, filled and sealed:
A. critical area
B. Controled area
C. assimilated Area
D. Think-tank area
E. filling area
Answer: B. Controlled area
295. This is the zone/part of room where filling
of sterile products or other sterile processes
take place:
A. critical area
B. Controled area
C. assimilated Area
D. Think-tank area
E. filling area
Answer: A. critical area
296. This type of pressure must be maintained
to ensure airflows from the cleanest space to
less clean space:
A. Negative pressure
B. Positive pressure
C. Intermittent pressure
D. slight pressure E. isobaric pressure
Answer: B. Positive pressure
297. This type of airflow is used where particle
sizes are relatively large.
A. Unidirectional Airflow
B. Non-unidirectional airflow
C. down flow
D. up flow
E. NOTA
Answer: B. Non-unidirectional airflow
298. This type of airflow is used when low
airborne concentrations of particles or bacteria
are present:
A. critical area
B. Controled area
C. assimilated Area
D. Think-tank area
E. filling area
Answer: A. critical area
299. A synthetic contaminant often used to test
high efficiency filters is composed of atomized
droplets of hot di-octyl-phthalate. This test
refers to:
A. DOP testing D. Two flow testing
B. Leak testing E. Scan testing
C. HC emery
Answer: A. DOP testing
300. It measures the ability of a HEPA filter to
remove fine particles
A. Arrestance D. Adsorption
B. Efficiency E. interference
C. Integrity
Answer: B. Efficiency

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